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| Effect of Sevoflurane Inhalation combined with Anesthesia on inflammatory response and anesthetic effect in patients undergoing laparoscopic radical operation for cervical cancer |
| SUN Yang |
| Department of Anesthesiology, Jiangxi Maternal and Child Health Hospital, Jiangxi Province, Nanchang 330006, China |
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Abstract Objective To investigate the effect of Sevoflurane Inhalation combined with Anesthesia on patients undergoing laparoscopic radical operation for cervical cancer. Methods The clinical data of 92 patients undergoing laparoscopic radical operation for cervical cancer in our hospital from February 2016 to March 2018 were retrospectively analyzed. They were divided into the observation group (Sevoflurane Inhalation combined with Anesthesia) and control group (Propofol intravenous anesthesia), with 46 cases in each group. The effects of anesthesia, Interleukin-1 beta (IL-1β), Tumor necrosis factor-alpha (TNF-α) and heart rate (HR) were compared. Results There was no significant difference in anesthesia time between the two groups (P＞0.05). The time opening eyes, the time of recovery of spontaneous breathing, the time of recovery of orientation, and the time of speech response in the observation group were shorter than those in the control group (P＜0.05). The level of IL-1β and TNF-α in the observation group 10 minutes after pneumoperitoneum and 10 minutes after operation were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in HR between the two groups before anesthesia(P＞0.05). The HR in the observation group 10 minutes after pneumoperitoneum and 10 minutes after operation were lower than those in the control group, and the differences were statistically significant (P＜0.05). The level of IL-1β and TNF-α in the two groups 10 minutes after pneumoperitoneum and 10 minutes after operation were higher than those before anesthesia, and the differences were statistically significant (P＜0.05). The HR in the control group 10 minutes after pneumoperitoneum and 10 minutes after operation were higher than that before anesthesia (P＜0.05). The HR in the observation group 10 minutes after pneumoperitoneum was higher than that before anesthesia (P＜0.05). There was no significant difference in HR of the observation group before anesthesia and 10 minutes after operation (P＞0.05).Conclusion The recovery time of spontaneous breathing and speech response of patients undergoing laparoscopic cervical cancer radical operation under sevoflurane inhalation combined anesthesia is short, and the effect on inflammatory response and HR value is relatively small.
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