经会阴超声测量宫颈长度、胎儿纤维连接蛋白联合血清一氧化氮在预测早产中的临床价值

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Abstract Objective To investigate the value of transperineal ultrasound measurement of cervical length, fetal fibronectin and serum NO in predicting preterm delivery. Methods From January 2016 to December 2017, 50 pregnant women with threatened preterm birth (observation group) and 50 healthy pregnant women (control group) were enrolled in the People′s Hospital of Chenghai District in Shantou City of Guangdong Province, respectively. Fetal fibronectin combined with serum NO was detected and its predictive value was analyzed. Results The length of the cervix in the observation group was significantly shorter than that in the control group. The levels of fetal fibronectin and serum NO were significantly higher than those in the control group (P＜0.05). Correlation analysis showed that there was a significant negative correlation between cervical length and fetal fibronectin (r=-0.542, P=0.011), and cervical length was significantly negatively correlated with serum NO (r=-0.403, P=0.028), fetal fiber. Connexin was significantly positively correlated with serum NO (r=0.349, P=0.028). The optimal threshold for cervical length alone detection was 29.75 mm,area under the curve (AUC)=0.859, P=0.010, 95% confidence interval was (0.787, 0.931), sensitivity was 75.27%,specificity was 73.83%； optimal threshold for fetal fibronectin alone detection 78.21ng/ml, AUC=0.762, P=0.013, 95%confidence interval was (0.661, 0.863), sensitivity was 69.08%, specificity was 71.17%； optimal threshold for serum NO detection alone was 25.75 μmol/L, AUC=0.882, P=0.006, 95% confidence interval was (0.814,0.949), sensitivity was 73.81%, specificity was 77.08%. The AUC joint detection was 0.930, P=0.013, 95% confidence interval was (0.876, 0.984), sensitivity was 83.27 %, specificity was 81.35%. Conclusion The length of cervix in premature pregnant women is significantly shorter than that in healthy women. The levels of fetal fibronectin and serum NO are significantly higher than those of healthy women. The measurement of cervical length, fetal fibronectin and serum NO by perineal ultrasound is more predictive of preterm birth than the separate test. .

Key words： Transesophageal ultrasound Cervical length Fetal fibronectin Serum NO

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	LIN Qiao-yu
	LUO Mei-hua

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LIN Qiao-yu,LUO Mei-hua. Clinical value of transperineal ultrasound measurement of cervical length,fetal fibronectin and serum nitric oxide in predicting preterm delivery[J]. 中国当代医药, 2019, 26(9): 112-116.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I9/112

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