瑞舒伐他汀治疗高脂血症的效果和安全性

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Abstract Objective To explore the effect and safety of Rosuvastatin in the treatment of hyperlipidemia. Methods Forty-six patients with hyperlipidemia admitted to our hospital from December 2016 to December 2017 were selected as the study subjects, they were divided into group A (n=23) and group B (n=23) according to random number table method. Group A was given symptomatic treatment + Simvastatin, group B was given symptomatic treatment + Rosuvastatin, the total effective rate, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) levels and adverse reactions before and after treatment were compared between the two groups. Results The total effective rate of group B (95.65%) was significantly higher than that of group A(65.22%), the difference was significant (P＜0.05). The levels of TC, TG and LDL-C in the two groups after treatment were lower than those before treatment, the levels of HDL-C were higher than those before treatment, the levels of TC,TG and LDL-C in group B were lower than those in group A, the levels of HDL-C were higher than those in group A,the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in group B (13.04%) was significantly lower than that in group A (47.83%), the difference was statistically significant (P＜0.05). Conclusion Rosuvastatin has a good therapeutic effect on hyperlipidemia patients, can significantly improve the blood lipid metabolism, reduce cholesterol and low density lipoprotein cholesterol levels, drug safety is high.

Key words： Hyperlipidemia Simvastatin Rosuvastatin Therapeutic effect Lipid metabolism Safety

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	Articles by authors
	YANG Jing
	LAI Xiao-hua
	LIAO Shang

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YANG Jing,LAI Xiao-hua,LIAO Shang. Effect and safety of Rosuvastatin in the treatment of hyperlipidemia[J]. 中国当代医药, 2019, 26(9): 130-132.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I9/130

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