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2017 Vol. 24, No. 13
Published: 2017-05-08
 
 
4 Meta analysis of Kangai Injection combined with FOLFIRI for the treatment of colorectal cancer
ZHANG Li-na;WANG Yuan-yuan;QIU Chao-ping;SU Ting;YE Hui;SHI Xian-fang
ObjectiveTo discuss and systematically evaluate the clinical effect and safety of Kangai Injection combined with FOLFIRI for the treatment of colorectal cancer.MethodsPubmed,the Cochrane Library,SCI,CNKI,VIP,CBM,Wan Fang Database were searched using computer.August 10,2016 was search deadline.Clinical randomized controlled study of Kangai Injection combined with FOLFIRI chemotherapy plan applied in colorectal cancer was collected,and the effective rate,the improvement rate of quality of life and adverse reaction related data among the studies were added and combined.Differences of curative effect of two drug combination group and single FOLFIRI group were compared and analyzed.According to the inclusion and exclusion criteria,two researchers independently selected and searched the literature,extracted the data and Meta analysis was conducted using Revman 5.0 software.ResultsA total of 4 studies were included involving 299 patients.Meta analysis results showed that there was a statistical difference of the effective rate between the Kangai Injection combined with FOLFIRI chemotherapy plan (the combined group)and single FOLFIRI chemotherapy plan group after treatment(P＜0.01;OR=1.82,95%CI=1.16-2.87).There was a statistical difference of the improvement rate of quality of life between the combined group and single FOLFIRI plan (P＜0.01;OR=2.32,95%CI=1.33-4.07).The incidence rate of white blood cell reduction in the combination group was statistically significant lower than that of the single FOLFIRI chemotherapy plan group,and there was a statistical difference(P＜0.01;OR=51.46,95%CI=10.36-255.67).Theincidence rate of nausea and vomiting in the combination group was statistically significant lower than that of the FOLFIRI chemotherapy group and there was a statistical difference(P＜0.01;OR=0.33,95%CI=0.15-0.73).There was no significant difference between the two groups in the aspects of platelet reduction,liver and renal function damage and diarrhea (P＞0.05).ConclusionKangai Injection combined with FOLFIRI chemotherapy plan is better than single FOLFIRI chemotherapy plan in the aspects of effect for treating advanced colorectal cancer and reducing the adverse reaction.
2017 Vol. 24 (13): 4-8转19 [Abstract] ( 181 ) HTML (52 KB)  PDF  (0 KB)  ( 59 )
9 Study on gene polymorphism of MSP-1 and MSP-2 of Plasmodium falciparum in Bioko Island in Equatorial Guinea
CHEN Jiang-tao;LI Jian;PAN Xue-feng;Urbano Monsuy Eyi;Rocio Apicante Matesa;Maximo Miko Ondo Obono;Carlos Sala Ehapo;ZHA Guang-cai;HUANG Guang;HUANG Zhi-xiu;LIN Min
ObjectiveTo study the type of Plasmodium falciparum MSP-1(PfMSP-1)and PfMSP-2 gene in Bioko Island of Equatorial Guinea.Methods181 blood samples were collected from patients with malaria in Bioko Island.Microscopy and fluorescence quantitative PCR were used to identify the insect species.Nested PCR was used to amplify the specific fragment of PfMSP-1 and PfMSP-2 respectively,then the allele typing was conducted.ResultsPfMSP-1 genotypes:178 (98.34%)PfMSP-1 gene fragments were amplified from the 181 blood samples.MAD20-type,K1-type and RO33-type alleles were obtained from 171(94.48%),175(96.69%)and 126(69.61%)samples respectively.The mixed infection rate was 97.24%.PfMSP-2 genotypes:173(95.58%)PfMSP-2 gene fragments were amplified from the 181 blood samples of patients. Single 3D7-type and single FC27-type alleles were obtained in 8(26.52%)and 4(2.21%)samples respectively.The mixed infection rate was 66.85%.ConclusionPfMSP-1 and PfMSP-2 from Bioko Island are widespread.Mixed infection is the main type of malaria in Bioko Island.
2017 Vol. 24 (13): 9-12 [Abstract] ( 150 ) HTML (41 KB)  PDF  (0 KB)  ( 34 )
13 Research progress of the occurrence and the intervention therapy of small for gestational age
WANG Guang-bin
The incidence of physique development deficiency is higher in small for gestational age (SGA)infants than appropriate for gestational age infants.They often concurrent suffocated in the perinatal period,therefore it always leads to some neurological sequelae.The occurrence of SGA mainly associated with maternal factors including demographic characteristics,exposure factors and complication of pregnancy women,and etc.Meanwhile,it is also associated with environmental factors and other factors,these provide a basis for the prevention of SGA.SGA intervention treatment is particularly important,including early nutritional intervention,growth hormone therapy and drug treatment to the brain damage in the perinatal period SGA,and etc.
2017 Vol. 24 (13): 13-16 [Abstract] ( 126 ) HTML (44 KB)  PDF  (0 KB)  ( 33 )
17 Progress of treatment of unexplained recurrent spontaneous abortion
GUO Yun-juan;HAN Hai-xia;GONG Ai-ling
Recurrent spontaneous abortion was the normal promble of the obstetrics and gynecology,it′s pathogensis was complicated and various,between forty percent and fifty percent was unexplained recurrent spontaneous abortion.Beacuse the cause was not clear,the patients suffered great physical and psychological harm,then it became the main factor of secondary infertility.About the treatment of URSA was the hotspot and difficulty in the present stage for the treatment of URSA has a variety of methods,this paper summarized the progress on treatment of URSA.
2017 Vol. 24 (13): 17-19 [Abstract] ( 149 ) HTML (34 KB)  PDF  (0 KB)  ( 32 )
20 Effect of Hybrid knife for endoscopic submucosal dissection in the treatment of gastrointestinal submucosal lesions
HUANG Zhong;WEI Wei;LI Zhi;CHEN Xin-lian
ObjectiveTo investigate the effect of Hybrid knife for endoscopic submucosal dissection in the treatment of gastrointestinal submucosal lesions.Methods80 hospitalized patients with gastrointestinal submucosal lesions treated in pur hospital from December 2015 to March 2017 were selected and they were randomly divided into Hybrid knife group (n=40)and control group(using conventional IT knife or Dual knife,n=40).The patients were all examined not have cardiopulmonary dysfunction,coagulation dysfunction and surgical contraindications.Operation index,curative effect and complications of two groups were observed.ResultsThe hospitalization time was(9.42±3.44)d in Hybrid knife group,and it was significantly shorter than that in control group[(12.00±4.36)]d(P＜0.05).Operative time was[(65.56±31.99)min] in HybridKnife group,and it was significantly shorter than that in control group[(104.37±42.38)min](P＜0.01).The size of the lesion between two groups had no significant difference(P＞0.05).The incidence rate of complications of abdominal pain(12.50%),perforation(2.50%)and it was shorter than that of control group(32.50%,15.00%)(P＜0.05).There was no statistical difference of the incidence rate of delayed hemorrhage between two groups(P＞0.05).The overall incidence rate of complications in the Hybrid knife group was 20.00%,which was significantly lower than the control group(52.50%) (P＜0.05).There was no significant difference of curative effect between two groups(P＞0.05).ConclusionHybrid knife for endoscopic submucosal dissection in the treatment of gastrointestinal submucosal lesions has the advantages of good effect,short operation and hospitalization time,less complications,and is worthy of clinical promotion and application.
2017 Vol. 24 (13): 20-22 [Abstract] ( 159 ) HTML (39 KB)  PDF  (0 KB)  ( 49 )
23 Effect comparison of laparoscope and open surgery in the treatment of peri-appendiceal abscess
ZHOU Wei-zhou;LUO Ze-bin;HUANG Gui-he
ObjectiveTo explore the effect of laparoscope and open surgery in the treatment of peri-appendiceal abscess.Methods96 cases clinical data of peri-appendiceal abscess in our hospital of general surgery department from February 2014 to February 2017 were retrospective analyzed,all patients were divided into the laparotomy group(46 cases)and the laparoscope group (50 cases)according to different operation treatment methods.The operation time,intraoperatve blood soss,postoperative exhaust time,24 h analgesic usage,hospital stays,exhaust time,body temperature recovery time,white blood cells back to normal time,and the incidence rate of infection of incisional wound,intra-abdominal abscess,pelvic within abscess,recurrence rate of the two groups were observed.ResultsThe bleeding volume in the laparoscopic group was less than that in the laparotomy group,and the use rate of 24 h analgesic in laparoscopic group was lower than that in the laparotomy group,hospital stay in the laparoscopic group was shorter than that in the laparotomy group,with significant difference (P＜0.05).The exhaust time,the recovery time of body temperature and the recovery time of white blood cells in the laparoscopic group was shorter than that in the laparotomy group,with significant difference(P＜0.05).The incidence rate of incision infection,intra-abdominal abscess,pelvic abscess and recurrence rate in the laparoscopic group was lower than that in the laparotomy group,with significant difference (P＜0.05).ConclusionLaparoscope in the treatment of patients with appendiceal abscess has the advantages of less trauma,faster recovery, fewer complications,it is worthy of clinical promotion and application.
2017 Vol. 24 (13): 23-25 [Abstract] ( 124 ) HTML (38 KB)  PDF  (0 KB)  ( 31 )
26 Analysis of the repair and cosmetic effect of dot matrix CO2laser in the treatment of pitting acne scar
GAO Chao-sheng;HE Xin-di
Objectives To study the repair and cosmetic effect of dot matrix CO2laser in the treatment of pitting acne scar.Methods100 cases of pitting acne scar from March 2014 to March 2015 in our hospital were selected and randomly divided into the control group and the observation group,50 cases in each group.The control group was treated with conventional laser therapy,while the observation group was treated with dot matrix CO2laser.Then splash area,scar size,ECCA score,quality of life,curative effect of the two groups were compared.ResultsThe splash area and scar area after treatment of the observation group was less than that of the control group,with significant difference(P＜0.05).ECCA score of the observation group was lower than that of the control group,with significant difference(P＜0.05).The score of self perception,social function,emotional function of the observation group was better than that of the control group, with significant difference (P＜0.05).The total effective rate of the observation group was higher than that of the control group,with significant difference (P＜0.05).ConclusionThe dot matrix CO2laser is effective in the treatment of pitting acne scars,and can effectively improve the patient′s concave scar,and can obtain satisfactory cosmetic results.
2017 Vol. 24 (13): 26-28 [Abstract] ( 148 ) HTML (42 KB)  PDF  (0 KB)  ( 67 )
29 Effect of Gabapentin in the treatment of intractable pruritus in hemodialysis patients
YU Lan
ObjectiveTo explore the effect of gabapentin in the treatment of hemodialysis patients with intractable pruritus.Methods86 cases of hemodialysis with intractable pruritus from September 2014 to December 2015 in our hospital were selected and randomly divided into the reference group and the study group,43 cases in each group.All the subjects were given hemodialysis 2 to 3 times a week,and the frequency of irrigation was about 2 times per month. The reference group was given Loratadine,10 mg daily,and the study group was given 0.1 to 0.3 mg Gabapentin in the evening after each dialysis.After 3 months of treatment,the VAS score and the VAG score of the two groups were recorded,the therapeutic effect was evaluated,and the adverse reactions was observed.ResultsThere was no significant difference between the two groups before treatment in the score of VAS,VAG (P＞0.05).The VAS and VAG scores after treatment of the two groups were lower than that before treatment,with significant difference(P＜0.05).The scores of VAS and VAG of the study group was lower than that of the reference group,with significant difference (P＜0.05).2 patients had mild nausea after treatment with gabapentin,did not immediately stop,7 days later,the symptoms disappeared,and no other adverse reactions.ConclusionGabapentin used a small dose of a short period of time will help to improve the hemodialysis patients with pruritus symptoms,improve the sleep quality of patients,the effect is significant,safe and reliable,but a long time use and long-term effect still needs to be further researched.
2017 Vol. 24 (13): 29-31转34 [Abstract] ( 157 ) HTML (42 KB)  PDF  (0 KB)  ( 66 )
32 Effect analysis of anal sphincter fistula ligation in the treatment of complex anal fistula
ZHANG Xiao-yong;AI Mei-fang
ObjectiveTo investigate the effect of anal sphincter fistula ligation in the treatment of complex anal fistula.MethodsFrom December 2015 to December 2016,90 patients with complex anal fistula were selected and randomly divided into the control group and observation group.The control group was treated with incision and threading.The observation group received anal sphincter fistula ligation surgery,clinical indicators and treatment effect between two groups were compared.ResultsThe operation time,hospitalization time and healing time of the observation group were shorter than those of the control group (P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group (P＜0.05).ConclusionAnal sphincter fistula ligation in the treatment of complex anal fistula can effectively shorten the operation time and speed up the healing time,and has a better clinical effect and it is worthy of application.
2017 Vol. 24 (13): 32-34 [Abstract] ( 145 ) HTML (35 KB)  PDF  (0 KB)  ( 78 )
35 Effect evaluation of improved milligan morgan hemorrhoidectomy combined with partial internal sphincterotomy in treatment of circumferential mixed hemorrhoids
LIU Xiao-bin;GUO Wen-tao;ZENG Zhi-hui
ObjectiveTo research the clinical effect of improved milligan morgan hemorrhoidectomy combined with partial internal sphincterotomy in treatment of circumferential mixed hemorrhoids.Methods80 patients with circumferential mixed hemorrhoids treated in our hospital from January 2015 to December 2016 were randomly divided into 2 groups according to the random number method,40 patients were treated with improved milligan morgan hemorrhoidectomy (the control group),40 patients were treated with improved milligan morgan hemorrhoidectomy combined with partial internal sphincterotomy (the study group).The pain score,wound edema degree,wound healing time and incidence rate of complications were observed and compared between the two groups.ResultsThe postoperative pain score of the study group was significantly lower than that of the control group (P＜0.05).Wound edema degree in the study group were significantly lighter than that in the control group(P＜0.05).The wound healing time[(12.54±2.64)d]in the study group was significantly shorter than that in the control group[(17.09±5.47)d](P＜0.05).The incidence rate of complications in the study group(5.0%)was significantly lower than that in the control group(32.5%)(P＜0.05).ConclusionImproved milligan morgan hemorrhoidectomy combined with partial internal sphincterotomy in treatment of circumferential mixed hemorrhoids can significantly reduce pain degree of patients,shorten wound healing time,reduce wound edema,reduce the incidence rate of complications,can help more patients on the rehabilitation.
2017 Vol. 24 (13): 35-37 [Abstract] ( 169 ) HTML (38 KB)  PDF  (0 KB)  ( 67 )
38 Changes of serum PCSK9 levels in patients with coronary heart disease combined with chronic heart failure and its clinical significance
WU Chun-yan
ObjectiveTo study the changes of serum proprotein convertase subtilisin/kexin 9(PCSK9)levels in patients with coronary heart disease combined with chronic heart failure and its clinical significance.Methods45 patients who met the diagnostic requirements of coronary heart disease with chronic heart failure from January to August in 2016 of Internal Medicine-Cardiovascular Department in our hospital were selected as the case group.40 coronary heart disease patients without chronic heart failure were selected as the control group.The concentration of total cholesterol(TC), triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),PCSK9 and high sensitive C reaction protein(hsCRP)in the two groups were compared.All the patients were collected fasting blood 5 ml at the second day of admission and the case group were collected peripheral venous blood 5 ml after treatment to test the level of serum PCSK9 and hsCRP.ResultsThere was no significant difference in the level of TC,TG,LDL-C, HDL-C between the two groups(P＞0.05).The level of PCSK9 and hsCRP before treatment in the case group was significantly higher than that in the control group before treatment,with significant difference (P＜0.05).There was significant difference in the level of plasma PCSK9 and hsCRP before and after treatment in the case group(P＜0.05).There was no significant difference in the level of PCSK9 and hsCRP before and after treatment in the control group (P＞0.05).The levels of PCSK9 and hsCRP after treatment in the case group was lower than that in the control group after treatment, with significant difference(P＜0.05).ConclusionThe serum PCSK9 level is closely related to chronic heart failure,which may be involved in the pathogenesis of chronic heart failure by promoting inflammation,and can provide new ideas for clinical prediction and search for new treatment and intervention measures for chronic heart failure.
2017 Vol. 24 (13): 38-40转44 [Abstract] ( 147 ) HTML (41 KB)  PDF  (0 KB)  ( 65 )
41 Clinical efficacy of CRT treatment in elderly patients with heart failure and analysis of non-response causes
YANG Jia
ObjectiveTo investigate efficacy of CRT treatment in elderly patients with heart failure and to analyze nonresponse causes.Methods31 elderly patients with heart failure in our hospital from October 2011 to November 2013 were selected and divided into the response group and the non-response group according to the results of CRT treatment.Heart function,clinical indexes were analyzed.ResultsThe treatment efficiency was 77.4%.After CRT,QRS wave duration in response group showed narrow while wide in non-response group.Classification of cardiac function in response group improved.LVEF and 6 min walking distance increased.Scar area integral,transmural extent,volume integral decreased,Nt-BNP reduced (P＜0.05).Preoperative left ventricular scar load,left ventricular electrode position and QRS wave duration were influencing factors of CRT treatment in elderly patients with heart failure.ConclusionCRT is an effective method in the treatment of elderly patients with heart failure,which can improve cardiac function.Non-response of CRT may be associated with left ventricular electrode position,complications,cardiac dyssynchrony.
2017 Vol. 24 (13): 41-44 [Abstract] ( 138 ) HTML (43 KB)  PDF  (0 KB)  ( 51 )
45 Diagnostic significance of nerve electrophysiological examination in critical illness myopathy
ZENG Zhi-liang;TANG Xiu-ming;LI Sui-sheng;GAO You-an;LI Zhan-hong;CHEN Xiong-hui;YANG Zhi-yong;LIU Fu-kun
ObjectiveTo investigate the diagnostic significance of nerve electrophysiological examination in critically illness myopathy.Methods30 cases with critically illness myopathy diagnosed treated in our hospital from January 2015 to December 2016 were selected and set as the observation group,at the same period of time,50 healthy subjects were selected and set as control group,subjects in two groups were given electrophysiological examination,and the motor nerve and sensory nerve electrophysiological examination results were analyzed and compared,and the compliance of electrophysiological examination in diagnosis of critical illness myopathy was counted.ResultsThe electrophysiological examination results of motor nerve showed that motor nerve conduction velocity and evoked potential amplitude of median nerve and ulnar nerve in observation group were significantly lower than those of the control group (P＜0.05),and distal latency of the motor evoked potential was significantly prolonged (P＜0.05).The electrophysiological examination results of sense nerve showed that sense nerve conduction velocity and evoked potential amplitude of median nerve and ulnar nerve in observation group were significantly lower than those of the control group(P＜0.05).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of electrophysiological examination for the diagnosis of critical illness myopathy was 96.67%,96.00%,96.25%,93.55%,97.96%respectively,and it was in good agreement with the diagnosis result(Kappa=0.724).ConclusionThe accuracy of the neurophysiological examination in the diagnosis of critically illness myopathy is high,and it can reflect the nerve injury of critically illness myopathy.
2017 Vol. 24 (13): 45-47 [Abstract] ( 132 ) HTML (38 KB)  PDF  (0 KB)  ( 69 )
48 Clinical efficacy of Butylphthalide Soft Capsules in the treatment of mild cognitive impairment after stroke
SHEN You-jin;WANG Dan;WAN Ting-yu;REN Qing-hua;REN Zhi-jun
ObjectiveTo explore the clinical efficacy of Butylphthalide Soft Capsules in the treatment of mild cognitive impairment after stroke.MethodsFrom January to December 2016,90 patients with mild cognitive impairment after stroke meeting the condition were included in the study.The patients were divided into observation group and control group by double-blind method.The patients were treated with basic therapy.The observation group was treated with Butylphthalide Soft Capsules.while the control group was treated by Piracetam and all patients were treated for 14 days. Plasma superoxide dismutase(SOD),mini mental state examination(MMSE)score,China stroke scale(CSS)score,activities of daily living scale (Barthel index)before and after treatment between two groups were compared.Efficacy and adverse reactions were compared between the two groups.ResultsAfter treatment,the level of plasma SOD increased and higher than that of the control group,and CSS score in the observation group was lower than that of control group,and Barthel and MMSE score were higher than those in the control group and the total effective rate(93.33%)in the observation group was higher than that in the control group (80.00%)(P＜0.05).There was no significant difference in the in cidence of adverse reactions between two groups（P＞0.05）.ConclusionButylphthalide Soft Capsules can improve the cognitive function of patients with mild cognitive impairment after stroke,reduce neurological deficits,improve the daily living ability,less adverse reactions,the effect is good,and it is worthy of promotion.
2017 Vol. 24 (13): 48-50 [Abstract] ( 165 ) HTML (37 KB)  PDF  (0 KB)  ( 65 )
51 Effect of Oxiracetam combined with Xueshuantong in the treatment of acute cerebral infarction
LIU Xue-yong;ZHENG Jia-ying
ObjectiveTo discuss the effect of Oxiracetam combined with Xueshuantong in the treatment of acute cerebral infarction.Methods140 patients with cerebral infarction treated in our hospital from January 2015 to December 2016 were selected and divided into observation group and control group according to random number table method,and each group had 70 cases.The two groups were given routine treatment,such as lowering blood glucose,expanding blood vessel,dehydration,reducing blood pressure,regulating lipid and stabilizing plaque,anti platelet aggregation and so on. The control group was given Xueshuantong Injection on the basis of conventional symptomatic treatment,while the observation group was given Oxiracetam Injection on the basis of treatment of the control group.The therapeutic effect of two groups was observed.ResultsThe total effective rate of the observation group was 90.0%,which was higher than that of the control group(65.7%)(P＜0.05).MoCA and MMSE score of the two groups after treatment were significantly improved,compared with before treatment,the difference was statistically significant(P＜0.05),and MoCA,MMSE score in the observation group after treatment were higher than those of the control group(P＜0.05).Barthel score of two groups after treatment were significantly improved,compared with before treatment,the difference was statistically significant (P＜0.05),and Barthel score of the observation group after treatment was higher than that of the control group(P＜0.05). NIHSS scores of two group after treatment were significantly decreased,compared with before treatment,the difference was statistically significant(P＜0.05),and NIHSS score of the observation group after treatment was lower than that of the control group(P＜0.05).ConclusionOxiracetam combined with Xueshuantong in the treatment of cerebral infarction can significantly improve the cognitive function of patients,reduce the neurological functional defect,improve the ability of daily life,and the curative effect is exact.
2017 Vol. 24 (13): 51-53 [Abstract] ( 149 ) HTML (43 KB)  PDF  (0 KB)  ( 7 )
54 Efficacy of standard large trauma craniotomy and routine craniotomy in patients with severe craniocerebral injury and influence on neurological function
HUANG Yi-ping;WEI Er-jia
ObjectiveTo efficacy of standard large trauma craniotomy and routine craniotomy in patients with severe craniocerebral injury and influence on neurological function.Methods60 cases of severe TBI patients admitted to our hospital from January 2015 to June 2016 were selected and divided into observation group and control group according to random number table,each with a total of 30 cases.The control group was treated with conventional craniotomy,while the observation group was treated with standard large decompressivecraniectomy.The therapeutic effects of the two groups were compared.ResultsThe rate of favorable prognosis in the observation group(50.0%)was higher than that in the control group(30.0%),the difference was significant(P＜0.05);the two groups preoperative neurological function score no significant difference after operation were significantly decreased,compared with the preoperative,the difference was statistically significant(P＜0.05);after 1 month and 2 months,the neurological function score in observation group[(19.6±2.3), (11.6±1.2)scores]were significantly lower than those in the control group[(29.7±2.9),(19.7±1.9)scores],comparison between groups,the difference was statistically significant(P＜0.05);The complication rate of the observation group was 6.67%,which was significantly lower than that of the control group(23.33%),the difference was statistically significant(P＜0.05).ConclusionThe standard large bone flap decompression for the treatment of severe TBI has a more significant effect,not only can reduce intracranial pressure,but also can improve the neurological function,reduce the incidence of complications,to protect the safety of the operation.
2017 Vol. 24 (13): 54-56 [Abstract] ( 146 ) HTML (36 KB)  PDF  (0 KB)  ( 43 )
57 Relationship of mineral and bone disorder with hs-CRP in maintenance hemodialysis patients
QIN Yan-dong;YAN Wen-fen;WU Xiao-lan;LI Min-hui;ZHOU Guo-yong
ObjectiveTo investigate the relationship of mineral and bone disorder with high sensitivity C reactive protein(hs-CRP)in maintenance hemodialysis patients.Methods78 patients with maintenance hemodialysis from hemodialysis room in our hospital from October 2015 to October 2016 were selected,the level of calciumion (Ca),phosphorus(P) and parathyroid hormone were determined,the hemodialysis sufficiency were calculated.The relationship of level of Ca,P and PTH with hs-CRP were investigated by multiple linear regression analysis.ResultsIn 78 patients,24 cases reached K/DNOQI electrolyte standards,compliance rate was 30.77%(24/78).There was significant difference in hs-CRP level between the standard group and the substandard group (P＜0.05).The level of hs-CRP were positive correlated with P and did not correlate with level of Ca and PTH.ConclusionThere is a close correspondence between mineral am bone disorder and hs-CRP,the level of P is independently an increased risk for hs-CRP.
2017 Vol. 24 (13): 57-59 [Abstract] ( 162 ) HTML (37 KB)  PDF  (0 KB)  ( 36 )
60 Study on the effect of continuous renal replacement therapy and intermittent hemodialysis in the treatment of severe acute renal failure
AN Ling-chun;GAO Yang;HUANG Chun-quan
ObjectiveTo analyze the clinical efficacy of continuous renal replacement therapy and intermittent hemodialysis in the treatment of severe acute renal failure.Methods46 patients with severe acute renal failure from May 2014 to March 2016 in our hospital were selected and divided into the observation group and the control group according to the difference of treatment methods,23 cases in each group.The control group was given selective intermittent hemodialysis in the clinical treatment,and the observation group was given continuous renal replacement therapy in the clinical treatment.The clinical efficacy was compared between the two groups after treatment.ResultsThe total effective rate after treatment in the observation group was 91.30%,which was hifher than that in the control group (73.91%),with significant difference (P＜0.05).The levels of BUN and SCr after treatment in the observation group was lower than that in the control group,and the level of CCr after treatment in the observation group was higher than that in the control group,with significant difference(P＜0.05).The survival rate of 1 year in the observation group was 82.61%,which was higher than that in the control group(60.87%),with significant difference(P＜0.05).ConclusionThe effect of continuous renal replacement therapy in the treatment of patients with severe acute renal failure is significant,which can improve the clinical symptoms and improve the survival rate of patients,it is worthy of clinical promotion and application.
2017 Vol. 24 (13): 60-62 [Abstract] ( 151 ) HTML (38 KB)  PDF  (0 KB)  ( 33 )
63 Effect of Chinese Herbal Compound of Tonifying Kidney and Strengthening Spleen on CTGF and Osterix factor expression in callus of osteoporotic fracture
GONG Hui-song
ObjectiveTo analyze the influence of Chinese Herbal Compound of Tonifying Kidney and Strengthening Spleen on CTGF and Osterix factor expression in callus of osteoporotic fracture.Methods60 female SD rats of cleanclass aged six-month were selected and they were randomly divided into 3 groups:model group,western medicine group and traditional Chinese medicine group(TCM group)(n=20).After the success of the osteoporosis′fracture model,TCM group was given Chinese Herbal Compound of Tonifying Kidney and Strengthening Spleen and the western medicine group was given sodium alendate suspension.The model group was given routine culture.After 1 month,the callus of each group was taken and cultured in vitro.The callus of each group was cultured with the corresponding serum.CTGF and Osterix expression in each group were detected by fluorescence quantitative PCR.ResultsThe expression of CTGF mRNA in TCM group and western medicine group was significantly higher than that in model group(P＜0.05).Osterix mRNA level in TCM group and western medicine group were significantly higher than those in model group(P＜0.05),and the content of Osterix mRNA in TCM group was higher than that in western medicine group (P＜0.05).ConclusionChinese herbal Compound of Tonifying Kidney and Strengthening Spleen can promote the growth of callus to a certain extent,thus promote fracture healing,and it provides the new way for the mechanism and prevention and treatment methods osteoporosis′fracture healing.
2017 Vol. 24 (13): 63-65转77 [Abstract] ( 129 ) HTML (43 KB)  PDF  (0 KB)  ( 37 )
66 Clinical effect analysis of modified intermittent vacuum sealing drainage (VSD)combined with surgical flaps in the treatment of type Gustilo type Ⅲfracture of the middle and inferior segment of tibia and fibula
ZHANG Xian-liao;HUANG Liu-ying;LIU Jian-jian;WANG Yong;GUO Jian-zhong
ObjectiveTo investigate the clinical effect of modified intermittent vacuum sealing drainage (VSD)combined with surgical flaps in the treatment of Gustilo typeⅢfractures of the middle and inferior segment of tibia and fibula.Methods39 cases of primary suture of soft tissue injury of Gustilo typeⅢopen fractures of the middle and inferior segment of tibia and fibula in our hospital from January 2015 to June 2016 were selected and divided into the observation group (20 cases)and the control group (19 cases)according to the VSD method.The observation group was treated with modified intermittent VSD,while the control group was treated with general continuous VSD.The effect of the two groups was compared.ResultThe total effective rate of the observation group was 95.00%,which was significantly higher than that of the control group(57.89%)(P＜0.05).The two times skin flap and skin grafting rate in the observation group was 10.00%,which was lower than tha in the control group(47.39%),with significant difference(P＜0.05). The incidence rate of complication in the observation group was 30.00%,which was lower than that of the control group (78.94%),with significant difference(P＜0.05).ConclusionThe effective rate,the frequency of catheter obstruction and the length of hospital stay of modified intermittent VSD combined with surgical flaps in the treatment of type Gustilo typeⅢfracture of the middle and inferior segment of tibia and fibula is better than that of the conventional continuous VSD in the treatment of Gustilo typeⅢfractures,which can reduce the number of replacement of VSD,shorten the hospitalization time,save the cost of treatment.
2017 Vol. 24 (13): 66-68 [Abstract] ( 129 ) HTML (37 KB)  PDF  (0 KB)  ( 44 )
69 Effect comparison of PFNA and DHS in the treatment of intertrochanteric fractures in elderly patients
LYU Ping;HUANG Hai-yang;HUANG Wen-dong
ObjectiveTo explore the advantages and disadvantages of proximal femoral nail antirotation (PFNA)and dynamic hip screw (DHS)in the treatment of intertrochanteric fractures of the elderly patients,to determine its clinical significance.Methods150 elderly patients with intertrochanteric fractures diagnosed in our department from March 2010 to September 2015 were selected and divided into group A(80 cases)and group B(70 cases)according to the different internal fixation methods.Group A was treated with PFNA,group B was treated with DHS.The general condition, efficacy,the incidence rate of complication and fracture healing time between the two groups were compared.ResultsThe intraoperative blood loss of group A was less than that of group B,and the operative time and fracture healing time in group A was shorter than that in group B,with significant difference (P＜0.05).There was no significant difference in the excellent and good rate between the two groups (P＞0.05).The incidence rate of complication in group A was lower than that in group B,with significant difference (P＜0.05).ConclusionApplication of PFNA internal fixation in the treatment of intertrochanteric fractures in elderly patients can shorten the operation time,reduce complications,and facilitate fracture healing.
2017 Vol. 24 (13): 69-71 [Abstract] ( 150 ) HTML (36 KB)  PDF  (0 KB)  ( 39 )
72 Effect of short segment pedicle screw fixation in the treatment of nonadjacent multi segmental spinal fractures
GU Zu-chao;ZHANG Yu
ObjectiveTo explore the clinical effects of short segment pedicle screw fixation in treatment of non-adjacent multi segmental spinal fractures.Methods80 cases of non-contiguous spinal fractures in our hospital of Department of orthopedics ward from January 2015 to January 2017 were selected and randomly divided into the reference group and the study group,40 cases in each group.The reference group was treated with long segmental pedicle screw fixation,while the study group was treated with short segment pedicle screw fixation.Then,the treatment condition and clinical efficacy of the two groups were observed.ResultsThe operation time of the study group was shorter than that of the reference group,and the amount of bleeding of the study group was less than that of the reference group,with significant difference (P＜0.05).The incidence rate of postoperative complications in the study group was lower than that in the reference group,with significant difference(P＜0.05).The Frankel grade of the study group was better than that of the reference group,with significant difference(P＜0.05).The anterior height ratio of the injured vertebrae after operation in the study group was higher than that of the reference group,and the Cobb angle after operation in the study group was smaller than that of the reference group,with significant difference(P＜0.05).ConclusionThe clinical treatment effects of short segment pedicle screw fixation in the treatment of non-adjacent multi segmental spinal fractures is significant,the safety is high,it is worth learning.
2017 Vol. 24 (13): 72-74 [Abstract] ( 151 ) HTML (40 KB)  PDF  (0 KB)  ( 32 )
75 Effect comparision of eccentric exercise,extracorporeal shock wave therapy and combined use treating lateral epicondylitis
WU Mei;HE Xing-fei;LIU Wen-rong
Objectiveto discuss the effect of eccentric exercise (EE),extracorporeal shock wave therapy (ESWT)and combined use treating lateral epicondylitis.Methods60 cases with lateral epicondylitis treated in our hospital from March 2015 to May 2015 were selected and they were randomly divided into the three groups according to the voluntary of patients:ESWT treatment group,EE joint ESWT treatment group,EE treatment group,and each group had 20 patients respectively.Before treatment and in 2 weeks after treatment,visual analogue scale (visual analogue scale,VAS) was used to compare the treatment effect of various groups.Results2 weeks after treatment,VAS score of the three groups were significantly lower than those before treatment(P＜0.05),and there was no significant difference in VAS score between the two groups after treatment(P＞0.05).The total effective rate of ESWT treatment group (68.42%)and EE treatment group(70.59%)was significantly lower than that of EE combined with ESWT treatment group(94.74%), and the difference was statistically significant(P＜0.05).ConclusionThe effect of EE combined with ESWT treatment is significant,and it can be promoted and applied in clinic.
2017 Vol. 24 (13): 75-77 [Abstract] ( 139 ) HTML (36 KB)  PDF  (0 KB)  ( 40 )
78 Study on the correlation between high risk factors of colon cancer and colonic lesions in Nanchang area
LIU Xiao-hui
ObjectiveTo investigate the incidence rate of precancerous lesions for colon cancer in high-risk population of colon cancer through the colonoscopy screening the population having high-risk factors of colon cancer in Nanchang area to provide the basis for the early diagnosis and treatment of colon cancer.Methods158 cases having the high-risk factors of colon cancer and meeting the inclusion criteria were selected from 1128 healthy volunteers enrolled in the various community of Nanchang City from January 2012 to January 2016.158 cases were given the electron colonoscopy and pathology examination.The high risk rate of high-risk factors (family history of colon cancer and tumor,long-term drinking,history of polyps,chronic constipation,chronic diarrhea,bloody mucus,mental illness,disease of appendix,positive fecal occult blood)for high risk population of different age groups and the rate of colonoscopy,the detection rate of polyps and the number of severe atypical hyperplasia,and the correlation between high risk factors and severe atypical hyperplasia were counted.ResultsThe highest risk rate of high risk population in different age groups was 50-59 and 60-69 years old,and it was accounting for 17.94%and 18.35%respectively.The lowest in the 20-29 age group (7.69%).The proportion of high-risk factors,colonoscopy proportion was the highest in bloody mucus and fecal occult blood positive, and it was accounting for 29.11%and 30.38%,93.47%and 100.00%respectively.The detection rate of polyps was the highest in appendix disease,fecal occult blood positive,and it was both accounting for 66.67%.The correlation between high risk factors and severe atypical hyperplasia showed that there was a positive correlation between the incidence of family history of colorectal cancer,intestinal polyps,mucus bloody stool,fecal occult blood and severe atypical hyperplasia (P＜0.05).ConclusionThe detection rate of severe atypical hyperplasia in high-risk groups with visceral bloody stool and fecal occult blood is the highest,they are important risk factor of colon cancer,which plays a positive role in the early prevention of colorectal cancer.
2017 Vol. 24 (13): 78-80 [Abstract] ( 126 ) HTML (38 KB)  PDF  (0 KB)  ( 16 )
81 Application of serum pepsinogen and gastrin-17 combined with endoscopic screening protocol in early gastric cancer
XIE Jun-feng;WU Xiao-juan;XIE Ning-sheng;TANG Jian-hua
ObjectiveTo investigate the effect of pepsinogen (PG)and gastrin-17 (G-17)combined with endoscopic screening in the diagnosis of early gastric cancer.MethodsFrom January 2015 to December 2015,145 outpatient and inpatient 145 subjects because of upper abdominal pain,belching and other symptoms of upper digestive tract in our hospital were selected and divided into the normal group(n=30),the atrophic gastritis group(n=28),the gastric ulcer group (n=25),the early gastric cancer group (n=32)and the advanced gastric cancer group (n=30)according to endoscopic biopsy and histopathological examination.The levels of serum PGⅠ,PGⅡand G-17 were detected,and their value in the diagnosis of gastric cancer was discussed.ResultsThe levels of PGⅠand PGR in the atrophic gastritis group,the early gastric cancer group and the advanced gastric cancer group was lower than that in the normal group,the G-17 level was higher than in the normal group(P＜0.05).The levels of PGⅠand PGR in the atrophic gastritis group and the gastric ulcer group was higher than that in the early gastric cancer group,the levels of PGⅠand PGR in the advanced gastric cancer group was lower than that in the early gastric cancer group,the level of G-17 in the advanced gastric cancer group was higher than that in the early gastric cancer group (P＜0.05).The AUC of PGⅠ,PGⅡ,PGR,G-17 and joint detection in the gastric cancer group and the non-gastric cancer group was significantly higher than that in the control group(AUC= 0.5)(P＜0.05).Four groups of joint detection of AUC was higher than that in the single detection,the specificity and sensitivity of joint detection was higher than that in the non-gastric cancer group.ConclusionThe PGⅠ,G-17 combined with endoscopic screening is help to improve the early diagnosis rate of gastric cancer,it is worthy of clinical promotion and application.
2017 Vol. 24 (13): 81-83 [Abstract] ( 142 ) HTML (37 KB)  PDF  (0 KB)  ( 41 )
84 Effect observation of Recombinant Human P53 Adenovirus Injection combined with regional heperthermia and chemotherapy treating advanced pancreatic cancer
FAN Yu-fei;QIN Yuan;LI Ding-gang
ObjectiveTo explore the effect of Recombinant Human P53 Adenovirus Injection combined with regional heperthermia and chemotherapy treating advanced pancreatic cancer.MethodsForty-eight patients with advanced pancreatic cancer treated by department of oncology in our hospital from July 2006 to July 2012 were retrospectively analyzed.Patients had moderate to massive ascites.These patients were divided into research group and control group according to different treatment methods.The research group:23 patients received gene therapy,Gemcitabine and Cisplatin chemotherapy,local hyperthermia.Control group:25 patients received Gemcitabine and Cisplatin systemic chemotherapy alone.The effect between two groups was compared.ResultsThe disease control rate was 78.26%in research group and it was 32.00%in control group,and the difference between the two groups was statistically significant(P＜0.05).The pain relief rate was 83.33%in the study group and it was 25.00%in control group and the difference was statistically significant between the two groups(P＜0.05).The incidence rate ofⅢ～Ⅳmyelosuppression was 21.74%in research group,and in was 24.00%in control group,and there was no statistical difference between the two groups(P＞0.05).ConclusionRecombinant Human P53 Adenovirus Injection combined with regional heperthermia and chemotherapy treating advanced pancreatic cancer can obtain higher disease control rate,effectively relief the pain,improve patients′quality of life,and without increasing bone marrow toxicity.
2017 Vol. 24 (13): 84-87 [Abstract] ( 138 ) HTML (44 KB)  PDF  (0 KB)  ( 39 )
88 Application value of CT combined with percutaneous biopsy in the diagnosis of small cell lung cancer
HUANG LingSONG Yuan-hong;ZENG Lan-hui;YUAN Mao-xiu;ZHOU Jian-zhong;YANG Peng;CAI Qi-gui
ObjectiveTo study the application value of CT combined with percutaneous biopsy in the diagnosis of small cell lung cancer.Methods60 Patients with small cell lung cancer treated in our hospital form January to December 2016 were selected and they were given CT scan,percutaneous puncture biopsy and pathological examination of the joint inspection,pathological examination was selected as the gold standard,CT scan imaging characteristics was observed and diagnostic coincidence rate was compared.ResultsThe coincidence rate of CT combined with percutaneous biopsy (96.67%)was higher than that of CT examination or percutaneous puncture biopsy(76.67%,80.00%)(P＜0.05),and the sensitivity,specificity,positive predictive rate was 82.76%,50.00%,97.96%respectively.The detection rate of the lesions located in the left lung,right lung and mediastinum was 40.00%,55.00%and 5.00%respectively.The detection rate of central lung cancer and peripheral lung cancer was 53.33%and 46.67%,respectively.ConclusionThe coincidence rate of CT combined with percutaneous puncture biopsy is higher in diagnosis of small cell lung cancer,and it is convenient for clinical early detection and treatment for patients,and it can prolong the survival time of patients and improve their quality of life,and the clinical application is high.
2017 Vol. 24 (13): 88-90 [Abstract] ( 138 ) HTML (41 KB)  PDF  (0 KB)  ( 42 )
91 Clinical effect evaluation of Apatinib Mesylate Tablets in the treatment of advanced non-small cell lung cancer
CHEN Er-hong;CHEN Zhi-cheng;CHEN Min-ling;CHE Ming-ying
ObjectiveTo study the clinical effect of Apatinib Mesylate Tablets in the treatment of advanced non-small cell lung cancer.Methods84 patients with non-small cell lung cancer in our hospital from January 2015 to August 2016 were selected and randomly divided into the study group and the routine chemotherapy group,42 cases in each group.The routine chemotherapy group was given routine chemotherapy regimen,the study group was given Apatinib Mesylate Tablets on the basis of the routine chemotherapy group.The total remission rate,the incidence rate of adverse reaction and the score of quality of life and the Cartesian score before and after treatment were compared between the two groups.ResultsThe remission rate of the study group was higher than that of the routine chemotherapy group,with significant diference(P＜0.05).The score of quality of life and the Cartesian score after treatment in the study group was higher than that of the routine chemotherapy group,with significant diference(P＜0.05).The incidence rate of adverse reactions in the study group was lower than that of the routine chemotherapy group,with significant diference (P＜0.05).ConclusionThe clinical effect of Apatinib Mesylate Tablets in the treatment of advanced non-small cell lung cancer is exact,which can effectively improve the clinical symptoms and quality of life,and reduce the side effects of conventional chemotherapy,safe and effective,it is worthy of promotion.
2017 Vol. 24 (13): 91-93 [Abstract] ( 154 ) HTML (40 KB)  PDF  (0 KB)  ( 29 )
94 Influence of laparoscopic surgery on postoperative CD4/CD8 level and IgG expression in patients with early endometrial carcinoma
WANG Zi-yan
ObjectiveTo investigate the influence of laparoscopic surgery on postoperative CD4/CD8 level and IgG expression in patients with early endometrial carcinoma.Methods88 patients with early endometrial carcinoma in our hospital from September 2014 to September 2016 were selected and divided into the observation group and the control group by random number table method,44 cases in each group.The control group was treated with open surgery and the observation group was treated with laparoscopic surgery.The perioperative indexes,indexes of immune function[T helper cell/cytotoxic T cell(CD4+/CD8+),immunoglobulin G (IgG)]and the incidence rate of complications of the two groups were compared.ResultsThe amount of intraoperative bleeding and pelvic drainage volume in the observation group was significantly less than that in the control group,and the postoperative exhaust time in the observation group was shorter than that of the control group,with significant difference(P＜0.05).The level of CD4+/CD8+after operation of the observation group was significantly higher than that of the control group,and IgG expression after operation of the observation group was significantly lower than that of the control group,with significant difference(P＜0.05).ConclusionLaparoscopic surgery is a safe and reliable treatment method of early endometrial carcinoma,it can effectively reduce the influence on immune function,promote postoperative recovery of physiological function,which is worthy of promotion.
2017 Vol. 24 (13): 94-96 [Abstract] ( 144 ) HTML (38 KB)  PDF  (0 KB)  ( 35 )
97 Clinicalresearch ofTrastuzumab combined with Gemcitabineor Capecitabine in the first-line treatment of HER-2 positive advanced breast cancer
HE Jiang-tao;WANG Wei
ObjectiveTo explore clinical effect of Trastuzumab combined with Gemcitabine or Capecitabine in the firstline treatment of HER-2 positive advanced breast cancer.Methods65 cases clinical data of HER-2 positive advanced breast cancer patients in our hospital from August 2012 to August 2016 were analyzed,which waere divided into the Herceptin combined with GEM group(30 cases)and the Herceptin combined with capecitabine group(35 cases)by different treatment method.The clinical efficacy and adverse reactions were observed in the two groups.ResultsThere was no significant difference between the two groups in the total remission rate of different metastatic sites (P＞0.05).There was no significant difference between the two groups in the incidence rate of adverse reactions,such as alopecia, leukopenia,thrombocytopenia,lower hemoglobin,gastrointestinal reaction,liver dysfunction,renal dysfunction,hand and foot syndrome and diarrhea (P＞0.05).ConclusionThe remission rate of Trastuzumab combined with Gemcitabine or Capecitabine in the first-line treatment of HER-2 positive advanced breast cancer is higher,adverse reactions can be tolerated,it is worthy of clinical promotion and application.
2017 Vol. 24 (13): 97-99 [Abstract] ( 154 ) HTML (36 KB)  PDF  (0 KB)  ( 37 )
100 The high-risk pregnancy management in rural women in Xinjian District of Nanchang City from 2007 to 2015 and its effects
QIU Chang-hui;LIU Ai-lian;XIE Wen
ObjectiveTo investigate the effect and application effect of high-risk pregnancy management in rural women in Xinjian district of Nanchang from 2007 to 2015.MethodsBefore the application of high-risk pregnancy management,28 682 rural pregnant women in Xinjian District of Nanchang City (overall 19 villages and towns)from 2003 to 2006 were selected as group A.After the application of high-risk pregnancy management,72 656 pregnant women in this district from 2007 to 2015 were selected as group B.The clinical data of pregnant women and pregnancy outcomes of neonates in two groups were retrospectively collected.The effects of rural high-risk pregnancy management in Xinjian district of Nanchang and related factors were analyzed.ResultsThere was no statistical difference in the rate of highrisk pregnant women between two groups(P＞0.05).The mortality rate of pregnant women,rate of low birth weight infants, fetal death and stillbirth rate,perinatal mortality rate of group A were higher than those of group B,and the rate of highrisk management,rate of postpartum visit,rate of establishing card,early detection rate,system management rate,hospitalized delivery rate of group A were lower than those of group B (P＜0.05).ConclusionSystem management conducted in rural parturient with high-risk pregnancy can effectively reduce the adverse pregnancy outcomes of high-risk pregnant women and the defect rate of perinatal infants and so on.The generalization of high-risk pregnancy screening in rural areas can strengthen service ability of rural health institutes and training of medical skills,and further enhances health education for pregnant women and their families,so as to improve health conditions of rural women.It is suggested that government continue to increase efforts to maternal and child health in rural areas.
2017 Vol. 24 (13): 100-102 [Abstract] ( 138 ) HTML (36 KB)  PDF  (0 KB)  ( 35 )
103 Efficacy of squatting labor in the second stage of labor on full-term pregnancy primiparas
GAN Xin-chun;ZHANG Wei;ZUO Mei-hua;LU Jiao;LI Ping

ObjectiveTo explore the efficacy of squatting labor in the second stage of labor on full-term pregnancy primiparas.Methods100 primiparas received vaginal delivery of single cephalic in our hospital from July 2015 to December 2016 were selected and divided into the observation group and the control group according to the random number table method,with 50 cases in each group.Primiparas in the obsevation group were given squatting labor in the second stage,while primiparas in the control group were given semi supine delivery in the second stage.The time of the second stage and the speed of fetal head descends were compared two groups.ResultsThe time of the second stage of primiparas in the observation group [(37.9±8.5)min]were shorter than that in the control group [(73.5±10.6)min],the speed of fetal head descends in the observation group[(3.7±1.1)cm/min]were faster than that in the control group[(2.4± 0.6)cm/min],the difference was statistically significant(P＜0.05).ConclusionFor the full-term pregnancy primiparas and in the second stage of labor,the squatting labor can shorten the time of the second stage of labor,and can improve the speed of fetal head descends,it has high clinical value,can be applied in clinic.
2017 Vol. 24 (13): 103-105 [Abstract] ( 140 ) HTML (35 KB)  PDF  (0 KB)  ( 37 )
106 Research on the correlation between serum 25-hydroxy vitamin D3and ultrasound bone mineral density in premature infants
LI Yuan-bin;LU Mei
ObjectiveTo investigate the correlation between serum 25-hydroxy vitamin D3levels and bone mineral density in premature infants.Methods76 neonates were born and hospitalized in Xiaolan Hospital Affiliated to Southern Medical University from May 2014 to February 2017.Among them,there were 30 cases of term infants and 46 cases of preterm infants.The basic situation was recorded at birth,The bone mineral density(SOS)of the middle tibia was measured within 24 hours after birth in the preterm infantile and term infants by quantitative ultrasound.The serum 25-hydroxy vitamin D3,parathyroid hormone(PTH),calcium(Ca),phosphorus(P)and alkaline phosphatase(ALP)levels in the preterm infants were measured at the 50th percentile(38 ng/ml)(≥38 ng/ml,26 cases)and preterm children B group(＜38 ng/ml, 20 cases)were analyzed in preterm children and term infants,premature children A group and premature children The difference of the above indexes between group B and the level of plasma vitamin D and the bone mineral density in premature infants.Results①The levels of 25-hydroxy vitamin D3in premature infants were lower than those in term infants(P＜0.01).②The bone mineral density of the tibia in the premature infants group was lower than that in the infants group(P＜0.01).③There was no significant difference in ALP and P between preterm infants and term infants(P＞0.05). There were significant differences in tibial bone mineral density,PTH,calcium ion and 25-hydroxy vitamin D3between group A and group B (P＜0.01),but no significant difference in serum phosphorus and ALP between the two groups(P＞0.05).⑤There was a positive correlation between the level of 25-hydroxy vitamin D3and Ca,tibial bone mineral density and PTH (P＜0.05),and had no correlation with P and ALP (P＞0.05).Conclusion①The density of tibial bone and the content of 25-hydroxy vitamin D3in premature infants were significantly lower than those of term infants.②The bone mineral density of tibial ultrasound in preterm infants with high levels of 25-hydroxy vitamin D3was higher than that of preterm infants with low levels of vitamin D3,Therefore,Supplementation of 25-hydroxy vitamin D3to promote premature infant bone growth,prevention of metabolic bone disease in premature children is important.
2017 Vol. 24 (13): 106-108转126 [Abstract] ( 103 ) HTML (41 KB)  PDF  (0 KB)  ( 23 )
109 Clinical analysis of 68 female psychotic patients with amenorrhea
YU Yun-xiang;LI Yu-chun;LI Xue-mei
ObjectiveTo explore the etiology and treatment of amenorrhea of female psychotic patients treated with various antipsychotic medications.MethodsRetrospective analysis of the data of 68 cases of amenorrhea female psychotic patients who visited the gynecology clinic or hospitalized in our hospital and were treated with various antipsychotic medications from June 2012 to December 2016.All the data,including the results of measurement of sex hormones(PRL, FSH,LH,E2,P and T)levels and results of ultrasonic inspection(uterus,accessories and endometrial thickness),were collected.ResultsIt was found from the analysis of these data that there were 12 cases of patients with normal level of sex hormones and normal results of ultrasonic inspection(17.64%),46 cases with Antipsychotic-induced hyperprolactinemia(HPRL)(67.64%),8 cases with higher level of follicle stimulating hormone(6 cases FSH＞10 IU；2 cases FSH＞40 IU)(11.76%) and 2 cases with higher level of PRL and FSH(2.94%).Resultsof ultrasonic inspection indicated that there were 51 cases of patients with normal of uterine and adnexal(75.00%),9 cases with uterus polyp(13.20%),3 cases with ovary cyst(7.00%), 5 cases with polycystic ovary (17.60%).There were 22 cases of patients with the thickness of endometrial≤5 mm (32.30%),38 cases with the thickness of endometrial between 5 mm (55.80%)and 10 mm and 8 cases with the thickness of endometrial≥10 mm (11.70%).ConclusionIt can be claimed from the analysis of these data that the main etiology of amenorrhea female psychotic patients is relative to their state of the nervous tension,stress,depression,anxiety and antipsychotic medications which they take,except to the natural decrease of function of ordinary ovary and the change of polycystic ovary.Thence,sex hormones measurement and ultrasonic inspection should be exerted as the periodic and routine screening program in the clinical application for amenorrhea of female psychotic patients treated with various antipsychotic medications in a considerable long term of time.
2017 Vol. 24 (13): 109-111 [Abstract] ( 111 ) HTML (39 KB)  PDF  (0 KB)  ( 29 )
112 Clinical efficacy of low molecular heparin in children with nephrotic syndrome
HU Ting;ZHONG Liang;LI Hao-hua;YANG Wei-si;XU Bai-hua
ObjectiveTo explore the Clinical efficacy of low molecular heparin in children with nephrotic syndrome.Methods100 children with nephrotic syndrome admitted to our hospital from February 2013 to February 2017 were selected and were divided into the observation group and the control group according to the method of lottery,with 50 cases in each group.Patients in the control group were given conventional therapy and prednisone while the observation group were given low molecular heparin on the basis of the control group.The levels of Cer,BUN,SCr,24 h urine protein, Alb and TC,PT,APTT and the incidence of adverse events were compared between two groups.ResultsThe levels of Cer,BUN,SCr,24 h urine protein and TC of patients in the observation group were lower than those in the control group; the level of Alb was higher than that in the control group;the PT and APTT were shorter than those in the control group;the incidence of adverse events was lower than that in the incidence of adverse events,and all the differences were statistically significant(P＜0.05).ConclusionLow molecular heparin in the treatment of children with nephrotic syndrome is effective and safe.
2017 Vol. 24 (13): 112-114 [Abstract] ( 126 ) HTML (36 KB)  PDF  (0 KB)  ( 36 )
115 Study on the consistency of two staging method of non proliferative diabetic retinopathy
FAN Li-min;YANG Bo;JI Qing;LI Nai-yang
ObjectiveTo observe the consistency of the two staging method of non proliferative diabetic retinopathy.MethodsA retrospective study was performed on 162 eyes of 84 patients with non proliferative diabetic retinopathy who were examined by FFA in our hospital from January 2014 to June 2016.The fundus photograph of each eye in each patient and FFA images was confucted staging according to six classification method in our county and international classification method respectively.The consistency of the two methods in each period was examined.ResultsAmong 162 eyes,according to the six classification method,nonmydriaticfundus photograph was taken as the standard,DR with phase Ⅰdiagnosed were 59 eyes,phaseⅡdiagnosed were 37 eyes,and phaseⅢdiagnosed were 66 eyes.50°of fundus photograph was taken as the standard,DR with phaseⅠdiagnosed were 52 eyes,phaseⅡdiagnosed were 38 eyes,and phase Ⅲdiagnosed were 72 eyes.According to the international stage method,mild NPDR,moderate NPDR and severe NPDR patients was 34 eyes,30 eyes and 92 eyes respectively and 6 eyes were in PDR patients.The consistency of fundus photograph under hitomi and 50°of two fundus photographs under mydriasis judging the clinical staging of DR was better (Kappa=0.91).The consistency of six classification method and international classification method was general(Kappa= 0.634).Mild NPDR was seen as the screening threshold,the sensitivity and specificity for lesion at stage 1 was 100.0% and 85.9%respectively,and middle NPDR was seen as the screening threshold,the sensitivity and specificity for lesion at stageⅡ was 66.6%and 86.3%respectively,and severe NPDR was seen as the screening threshold,the sensitivity and specificity for lesion at stageⅢ was 71.0%and 91.4%respectively.ConclusionThe international staging under the guidance of FFA is more able to reflect the microvascular pathological changes and severity of diabetic retinopathy. Early FFA examination should be performed for patients at phaseⅠ,ⅡandⅢdiabetic retinopathy with diffuse hemorrhages and hemangioma.
2017 Vol. 24 (13): 115-117 [Abstract] ( 144 ) HTML (38 KB)  PDF  (0 KB)  ( 34 )
118 Clinical effects on Xiyanping Injection of oxygen atomizing inhalation treating chronic pharyngitis
CAI Jian-ying;SHI Lei
ObjectiveTo study the clinical effect of Xiyanping Injection of oxygen atomizing inhalation treating chronic pharyngitis.Methods88 patients with chronic pharyngitis treated by our hospital from July 2013 to July 2015 were chosen.All patients were divided into observation group (45 cases)and control group (43 cases)according the random number table method and the observation group was given Xiyanping Injection of 50 mg+0.9%Sodium Chloride Injection of 4 ml for oxygen atomizing inhalation,while the control group was given Gentamicin injection of 80 000 U plus Dexamethasone Injection of 5 mg+Sodium Chloride Injection of 5 ml for oxygen inhalation therapy.Treatment effect between two groups was compared.ResultsThe total effective rate was 95.56%in the observation group,which was apparently higher than that in the control group(86.05%)(P＜0.05).The incidence of adverse reactions was 4.44%in the observation group,which was apparently lower than that in the control group(11.63%)(P＜0.05).The improved and disappearing time of symptoms and signs in the observation group were lower than those in the control group(P＜0.05).ConclusionXiyanping Injection oxygen for atomizing inhalation has significant clinical therapeutic effect on chronic pharyngitis.
2017 Vol. 24 (13): 118-120 [Abstract] ( 157 ) HTML (44 KB)  PDF  (0 KB)  ( 48 )
121 Effect of improved vacuum sealing drainage in adjuvant treatment of oral and maxillofacial space infection
XIE Yuan-hong
ObjectiveTo evaluate the effect of improved vacuum sealing drainage in adjuvant treatment of oral and maxillofacial space infection.MethodsFrom January 2010 to January 2017,82 patients with oral and maxillofacial space infection treated in our hospital were selected and they were randomly divided into the improved group (41cases)and conventional group (41 cases)and the two groups was given the self-control improved vacuum sealing drainage and conventional single tube vacuum sealing drainage on the basis of basic treatment.The clinical efficacy,extubation time, wound healing time,granulation tissue growth time,the days of antibiotic use,the related complications,hospitalization days,and hospital charges in patients between two groups were analyzed.ResultsThe total effective rate in improved group was 97.56%,which was significantly higher than those in conventional group (80.49%)(P＜0.05).The extubation time,wound healing time,granulation tissue growth time,the days of antibiotic use in the improved group were shorter than those of the conventional group (P＜0.05).The incidence rate of complications,hospital charges in the conventional group were obviously higher than those of the improved group,hospitalization days was was obviously longer than those of the improved group (P＜0.05).ConclusionImproved vacuum sealing drainage in adjuvant treatment of oral and maxillofacial space infection can obviously improve the clinical effect,and obviously shorten the hospitalization days,wound healing time,granulation tissue growth time,the days of antibiotic use with lower incidence rate of complications and hospitalization days,and it is worthy of promotion.
2017 Vol. 24 (13): 121-123 [Abstract] ( 110 ) HTML (37 KB)  PDF  (0 KB)  ( 36 )
124 Effect of anterior traction combined with rapid maxillary expansion treating skeletal malocclusion of classⅢin mixed dentition
WANG Ji;SHU Huang;KUANG Yi-yuan
ObjectiveTo study the effect of anterior traction combined with rapid maxillary expansion treating skeletal malocclusion of classⅢin mixed dentition.Methods41 patients with skeletal malocclusion of classⅢin mixed dentition treated by our outpatient from January 2015 to January 2016 were selected as the research objects,and they were given anterior traction combined with rapid maxillary expansion.SNA,SNB,ANB,SND,U1-NA,U1-NA Angle,L1-NB,L1-NB Angle were compared before and after the treatment.ResultsCompared with those indicators before the treatment, SNA angle increased,SNB angle narrowed,ANB angle increased,SND angle narrowed,U1-NA distance increased,and U1-NA angle increased,L1-NB distance increased,L1-NB angle increased,and the differences were statistically significant(P＜0.05).ConclusionAnterior traction combined with rapid maxillary expansion has the significant effect,which promotes the growth of maxilla,and inhibit the growth of mandible,and correct the skeletal malocclusion of classⅢ in mixed dentition and improve facial form.
2017 Vol. 24 (13): 124-126 [Abstract] ( 125 ) HTML (33 KB)  PDF  (0 KB)  ( 38 )
127 Influence of Desflurane on the muscle relaxation effect of Cisatracurium in patients with breast cancers
JIANG Qin-yong;CHEN Lin;XU Yong-min;ZHENG Yan-ping
ObjectiveTo explore the influence of Desflurane on the muscle relaxation effect of cisatracurium in patients with breast cancer so as to seek effective methods for clinical treatment of breast cancer patients.MethodsAltogether 40 ASA 1 or ASA 2 breast cancer patients undergoing simple mastectomy plus sentinel lymph node biopsy in our hospital from May 2016 to January 2017 were selected and randomly divided into the Desflurane group and the Sevoflurane group,20 cases in each group.The Desflurane group was inhaled with Desflurane.N2O(100-150 ml/min),O2(200-250 ml/min),ET O2(3.99-4.39 kPa)and intravenously injected with 0 6 mg/kg Atracurium(2 ED95)at 30 min.The Sevoflurane group was intravenously injected with 0.15 mg/kg Cisatracurium via upper extremity after anesthesia induction.The muscle relaxation effect of the two groups were compared.ResultsThere was no significant difference between the two groups in onset time and intubation time(P＞0.05).The time of no reaction,maintain time of block,T1 25%recovery time, T175%recovery time,TOF 70%recovery time and recovery index of the Desflurane group was longer than that of the Sevoflurane group,with significant difference(P＜0.05).There was no significant difference in the mean arterial blood pressure,oxygen saturation and heart rate at pre-induction between the two group (P＞0.05).While,There was significant difference in the mean arterial blood pressure,oxygen saturation and heart rate at post-induction between the two group (P＜0.05).ConclusionDesflurane can prolong the recovery time of the muscle relaxation effect of Cisatracurium,the anesthesia time is longer,the cisatracurium dosage use is lower,which indicates the enhanced role of Desflurane on muscle relaxation effect of Cisatracurium,and it is worthy of clinical promotion and perfection.
2017 Vol. 24 (13): 127-129转145 [Abstract] ( 155 ) HTML (42 KB)  PDF  (0 KB)  ( 33 )
130 Clinical application of Dexmedetomidine combined with proseal laryngeal mask airway in intracranial aneurysm embolization
LU Xian-qing;ZHANG Jian-hua;LIANG Jian-qun;OUYANG Wen-bo;HE Hui-jiao;YIN Wan-chun
ObjectiveTo evaluate the efficacy of Dexmedetomidine combined with proseal laryngeal mask airway in intracranial aneurysm embolization.MethodsFrom February 2015 to February 2017,60 patients underwent intracranial aneurysm embolization in our hospital were selected and randomly divided into the control group and the study group,43 cases in each group.The study group was given Dexmedetomidine before anesthesia induction and continuous intravenous infusion until 20 minutes before the operation finished;the proseal laryngeal mask airway was given after anesthesia induction.The control group was given the same amount of normal saline,the proseal laryngeal mask airway was given after anesthesia induction.The heart rate(HR)and blood pressures(SBP and DBP)before injection(T0),before intubation(T1),before intubation(T2),1 min after intubation(T3),the moment of puncture(T4),the moment of embolization (T5),the end of the operation(T6),before extubation(T7),1 min after extubation(T8)were evaluated.The recovery time of spontaneous breathing,the time of pulling out the laryngeal mask and the recovery time of the directional force after stopping drug were recorded.The adverse reactions of patients with laryngeal mask airway,the amount of Remifentanil used in each case and the types and times of vasoactive drugs were recorded.ResultsThe level of HR,SBP and DBP in the study group at T3and the control group at T3,T5,T8was higher than that at T0(P＜0.05).The HR,SBP and DBP in the study group at T1,T2,T4,T6and T7and the control group at T2,T4,T6and T7was lower than that at T0(P＜0.05).The HR,SBP and DBP in the study group at T1to T8were significantly lower than that in the control group (P＜0.05).The recovery time and extubation time in the study group was significantly shorter than that in the control group,the incidence of adverse drug reactions during the operation,the dosage of Remifentanil,and vasoactive drugs use in the study group was significantly lower than that in the control group(P＜0.05).ConclusionDexmedetomidine combined with proseal laryngeal mask airway in the embolization of intracranial aneurysms,the patient′s hemodynamics is stable,the recovery time and extubation time is short,it is worth promoting.
2017 Vol. 24 (13): 130-132转155 [Abstract] ( 127 ) HTML (48 KB)  PDF  (0 KB)  ( 40 )
133 Application ffect of Narcotrend EEG monitoring in general anesthesia for elderly patients
ZHANG Wei-jun;ZHANG Jun-ming;HU Xiao-fu
ObjectiveTo investigate the clinical efficacy of Narcotrend monitoring in elderly patients under general anesthesia.MethodsFrom January 2014 to December 2016,120 old patients who received general anesthesia in our hospital were selected and divided into group N(n=60)and group C(n=60)by taking random number table method.The propofol TCI concentration was regulated and controlled according to Narcotrend regulation of N group,the propofol TCI concentration was regulated and controlled according to the patient′s BP,HR and other vital signs of group C.The anesthesia time,operation time,recovery time,extubation time,PACU stay time after anesthesia,drug dosage and the incidence rate of adverse reaction were compared between the two groups.ResultsThe recovery time,extubation time and PACU stay time after anesthesia in group N was significantly shorter than that in group C,with significant difference (P＜0.05). The dosage of narcotic drugs in group N was significantly less than that in group C,with significant difference(P＜0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).ConclusionThe implementation of Narcotrend monitoring in the elderly patients with general anesthesia can reduce the use of anesthesia,promote postoperative recovery of consciousness.
2017 Vol. 24 (13): 133-136 [Abstract] ( 131 ) HTML (47 KB)  PDF  (0 KB)  ( 44 )
137 Application effect of Oxycodone combined with Propofol anesthesia in colonoscopy
LUO Xing-liao;XIAO Jian;LI Quan;JIN Qi-chen;NIE Li-jie;HU Yi
ObjectiveTo explore the efficacy of Oxycodone combined with Propofol in colonoscopy,and to provides the reference for its clinical application.MethodsFrom March 2015 to October 2016,100 patients undergoing colonoscopy in our hospital were selected and randomly divided into the Oxycodone group and the Fentanyl group,50 cases in each group.The oxycodone group was given Oxycodone combined with Propofol,and the fentanyl group was given Fentanyl combined with Propofol.The anesthesia effect in the two groups was compared.ResultsThere were no differences in anesthesia induction time,wake up time,heart rate,breathing rate,systolic blood pressure,diastolic pressure in the two groups(P＞0.05).The narcotic success dose,wake up dose and the EC50in the Oxycodone group was lower than that in the Fentanyl group,with significant difference (P＜0.05).The incidence rate of respiratory depression in the Oxycodone group was lower than that in the Fentanyl group,with significant difference (P＜0.05).ConclusionUnder the same anesthesia and anesthesia recovery,Oxycodone combined with Propofol in colonoscopy is safe and effective,and with less Propofol dosage.
2017 Vol. 24 (13): 137-139 [Abstract] ( 120 ) HTML (39 KB)  PDF  (0 KB)  ( 33 )
140 Study on clinical efficacy and safety of Omeprazole combined with Hemocoagulase in elderly patients with gastric ulcer accompanied with hemorrhage
JIANG Shao-ren;ZHANG Wei
ObjectiveTo investigate the clinical efficacy and safety of application of Omeprazole combined with Hemocoagulase in the treatment of elderly patients with gastric ulcer accompanied with hemorrhage.Methods76 elderly patients with gastric ulcer accompanied with hemorrhage who were diagnosed and treated in our hospital from August to December in 2016 were selected and randomly divided into the observation group and the control group,38 cases in each group.The observation group was treated with Omeprazole combined with Hemocoagulase,the control group was simply treated with Omeprazole.The hemostatic effect,ulcer healing conditions and the incidence rate of adverse reactions of the two groups were compared.ResultsThe hemostasis time of the observation group was (22.67±3.72)h,which was shorter than that of the control group[(37.42±5.65)h],with significant difference(P＜0.05).The total effective rate of the observation group was 94.74%,which was higher than that of the control group (76.32%),with significant difference (P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).ConclusionThe clinical effect of Omeprazole combined with Hemocoagulase in the treatment of elderly patients with gastric ulcer accompanied with hemorrhage is accurate,with rapid hemostasis and high safety,which can effectively promote ulcer healing without increase of adverse reactions in patients,it is worthy of clinical promotion and application.
2017 Vol. 24 (13): 140-142 [Abstract] ( 129 ) HTML (37 KB)  PDF  (0 KB)  ( 36 )
143 Clinical effect of Sertraline Hydrochloride Tablet in the treatment of post-stroke depression
WANG Li-jing;YE Shu-ping;ZHOU Hong;PENG Ya-zhuo;HAN Ya-nan
ObjectiveTo investigate the treatment effect of Sertraline Hydrochloride Tablet in the treatment of poststroke depression.Methods105 cases of post-stroke depression from May 2013 to February 2016 in our hospital were selected as the objects of study,which were divided into the study group(52 cases)and the control group(53 cases)according to the method of treatment.Patients of the two groups were given conventional treatment,on the basis of conventional treatment,the study group was given Sertraline Hydrochloride Tablet.All patients were treated for 8 consecutive weeks.The total effective rate,HAMD score,SSS score of the two groups were compared.ResultsThe total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P＜0.05).The score of HAMD,SSS of the two groups after treatment 4 weeks,8 weeks was significant lower than that before treatment, the difference was statistically significant(P＜0.05).The score of HAMD,SSS of the study group after treatment 4 weeks,8 weeks was lower than that of the control group,the difference was statistically significant(P＜0.05).ConclusionThe effect of Sertraline Hydrochloride Tablet in the treatmeng of post-stroke depression patients is significant,which can effectively improve the patient′s depression,and improve nerve function,it is recommended clinical use.
2017 Vol. 24 (13): 143-145 [Abstract] ( 117 ) HTML (36 KB)  PDF  (0 KB)  ( 32 )
146 Application effect observation of Pantoprazole combined with Bismuth Potassium Citrate in patients with gastric ulcer
ZOU Hui
ObjectiveTo investigate the effect of Pantoprazole combined with Bismuth Potassium Citrate in the treatment of patients with gastric ulcer.Methods71 cases of gastric ulcer in our hospital from February 2014 to November 2015 were selected as the research object,according to the order of admission number by using the random number table method,all the patients were divided into the control group(35 cases)and the observation group(36 cases).The control group was treated with Bismuth Potassium Citrate treatment,the observation group was treated with Pantoprazole combined with Bismuth Potassium Citrate treatment,the therapeutic effect of the two groups was observed.ResultsThe clinical symptom remission time and the time of complete disappearance of the lesions in the observation group was significantly shorter than that in the control group,with significant difference(P＜0.05).The total effective rate of the observation group was 91.7%,which was significantly higher than that of the control group (68.6%),with significant difference (P＜0.05).The incidence rate of adverse reactions and recurrence rate in the observation group was significantly lower than that in the control group,with significant difference(P＜0.05).ConclusionThe effect of Pantoprazole combined with Bismuth Potassium Citrate in the treatment of patients with gastric ulcer is prominent,which has the effect of Good, adverse reactions,not easy to relapse,and other advantages,it is worthy of clinical promotion.
2017 Vol. 24 (13): 146-148 [Abstract] ( 135 ) HTML (39 KB)  PDF  (0 KB)  ( 37 )
149 Focus on delicacy management of functional departments to improve the quality of medical services
ZHOU Hui-hua;XU Ming-yan;WANG Qin;GAN Yu;ZHANG Li
As a modern management tool,delicacy management is not only the need of the hospital′s own development, but also the inevitable choice of the hospital to surpass the competition and adapt to the social progress.Specialization as the premise,systematization as the guarantee,datamation as the basis,and informationization as the means,delicate planning is done for delicacy analysis,which are the powerful means to obtain core competition for hospital.Try to attract every employee to join in the quality-related activities in the whole management,constantly pursue the improvement of quality in order to achieve patient′s satisfaction and increase hospital competitiveness.From the aspects of hospital quality control,hospital management,and management of functional departments,the paper clarifies the long-term important significance of implementing delicacy management for the hospital.
2017 Vol. 24 (13): 149-151转159 [Abstract] ( 104 ) HTML (45 KB)  PDF  (0 KB)  ( 38 )
152 Hospital ethic management based on JCI evaluation criteria
DAI Ya-ning;WANG Zhen;ZHENG Qi-jin;NIU Li-hua
According to JCI standards,hospital leadership need to establish a framework for ethical management to ensure that patient care is provided within business,financial,ethical,and legal norms and protects patients and their rights. Ethical framework mainly deals with ethical issues in hospital operations,business and clinical services.Hssospital ethics management should be carried out according to JCI standards and needs the help of the hospital Ethics Committee and it helps to improve the overall level of hospital management and solve ethical problems in medical work,and ease the increasingly tense doctor-patient relationship.
2017 Vol. 24 (13): 152-155 [Abstract] ( 125 ) HTML (44 KB)  PDF  (0 KB)  ( 36 )
156 Effect of meticulous management based on medical failure mode and effect analysis in reducing catheter-associated urinary tract infection
QIU Chun-xia;YANG Zhi-hua;WANG Dong-ping;CHEN Wei-qiong;LIAO Guo-xia;DAI Hai-yan;ZHENG Li-ling;WANG Xu-lan
ObjectiveTo explore the effect of meticulous management based on medical failure mode and effect analysis (FMEA)applied in clinical management in reducing catheter-associated urinary tract infection(CAUTI).Methods120 patients with indwelling catheter in internal medicine ward of our hospital from October 2015 to February 2017 were selected as the study objects according to random number table method.56 cases of patients from October 2015 to April 2016 given routinue management model were set as the control group,and 64 cases of patients from May 2016 to February 2017 given FMEA management model were set as the observation group.The incidence rate and time of CAUTI,indwelling catheter time and son on were observed in all the patients given different management methods.ResultsThe risk priority index score(RPN)of the observation group was significantly lower than that of the control group(P＜0.01). The incidence rate of CAUTI in the observation group was lower than that of the control group,incidence time of CAUTI and indwelling catheter time in the observation group was shorter than that of the control group (P＜0.05).The compliance of nurses′hands in the observation group and the compliance rate of prevention of CAUTI were all significantly better than those of the control group(P＜0.05).ConclusionFMEA management model can effectively reduce the probability of CAUTI,and improve prognosis.It has certain reference value in clinical nursing.
2017 Vol. 24 (13): 156-159 [Abstract] ( 127 ) HTML (42 KB)  PDF  (0 KB)  ( 34 )
160 Nursing management efficacy of the rescue process after optimized in EICU
JIANG Li-juan;GU Yu-hui;YANG Xiao-li;YAN Hai-xia
ObjectiveTo explore nursing management efficacy of the rescue process after optimized in EICU.Methods60 patients who received treatments in EICU in our hospital from July 2015 to June 2016 were selected as the observation group and rescued by the optimized process.The other 60 patients hospitalized in EICU from July 2014 to June 2015 were selected as the control group and rescued by traditional process.The rescue preparation time,survival rate,the number of participating nurses,incidence of adverse care events and nursing satisfaction of family members of patients were compared between two groups.ResultsThe rescue preparation time of the observation group[(1.7±0.2)min]was shorter than that of the control group[(3.6±0.4)min],the survival rate(86.7%)was higher than that of the control group(66.7%), the number of participating nurses[(2.9±0.3)cases]was less than that of the control group[(4.5±0.4)cases],the incidence of adverse care events(3.3%)was lower than that of the control group(15.0%),the nursing satisfaction of family members of patients(90.0%)was higher than that of the control group(73.4%),all the difference was statistically significant (P＜0.05).ConclusionThe rescue process after optimized in EICU can save the rescue time,improve the success rate of rescue,save nursing staff.It is worthy of clinical application.
2017 Vol. 24 (13): 160-162 [Abstract] ( 113 ) HTML (41 KB)  PDF  (0 KB)  ( 39 )
163 Efficacy of family continuation nursing on postoperative pressure ulcer and nursing satisfaction in elderly patients with brain glioma
XU Qin;LIU Shu-yu;PENG Guo;XIE Xiao-hua
ObjectiveTo explore the efficacy of family continuation nursing on postoperative pressure ulcer and nursing satisfaction in elderly patients with brain glioma.Methods164 elderly patients with brain glioma after surgery from the Department of Neurosurgery in our hospital from December 2014 to November 2016 were selected and divided into the experiment group and the control group,with 82 cases in each group.Patients in the control group were given conventional nursing,while patients in the experiment group were given family continuation nursing on the basis of the control group.The caregiver care behavior score,braden pressure ulcer risk factor score,the incidence of pressure ulcer and nursing satisfaction were conpared between two groups.ResultsAfter intervation,the scores of the turning behavior,skin care,nutritional support in two groups were all increased and were higher than those before intervention,and those in experiment group were higher than those in control group,and the differences were statistically significant(P＜0.01).After intervation,the scores of indexes in Braden were all increased and were higher than those before intervention,and those in experiment group were higher than those in control group,and the differences were statistically significant(P＜0.01). The incidence of pressure ulcer in experiment was lower than that in the experiment group and the nursing satisfaction in experiment was higher than that in the experiment group,the differences were statistically significant(P＜0.05).ConclusionThe family continuation nursing can effectively enhance care behavior of caregivers,reduce the risk factors and incidence of pressure ulcer and improve nursing satisfaction of eldly patients with brain glioma.
2017 Vol. 24 (13): 163-166 [Abstract] ( 124 ) HTML (47 KB)  PDF  (0 KB)  ( 32 )
167 Application effect of self-psychological intervention in cesarean section
ZHOU Hong-qun
ObjectiveTo explore the application effect of self-psychological intervention in cesarean section.Methods100 cases of cesarean section from December 2013 to July 2014 in our hospital were selected and randomly divided into the observation group and the control group,with 50 cases in each group by taking single grouping method.The control group were given traditional passive psychological intervention,while the observation group were given self-psychological intervention based on the control group,the levels of maternal anxiety,depression,blood pressure and heart rate and nursing satisfaction were compare between two groups.ResultsBefore intervention,there were no significantly different among the scores of SAS and SDS in two groups(P＞0.05);after intervention,the scores SAS and SDS in two groups were all increased,and compared with those before nursing,the differences were statistically significant(P＜0.01). And those in the observation group were higher than those in control group,and the differences were statistically significant(P＜0.01).Before entering the operating room,there were no significantly different among the levels of blood pressure and heart rate in two groups(P＞0.05);After entering the operating room,those in the control group were increased,and compared with those before entering the operating room,the differences were statistically significant(P＜0.01),but there were no statistically significant differences in the obseration group between those before and after entering the operating room(P＞0.05).And those in observation group were lower than those in control group,and the differences were statistically significant(P＜0.01).The nursing satisfaction in the observation group were higher than those in control group,and the differences were statistically significant(P＜0.01).ConclusionThe self-psychological intervention of cesarean section can effectively alleviate the negative emotions of maternal and reduce the fluctuation of blood pressure and heart rate, which is beneficial to the smooth implementation of cesarean section and improve the satisfaction of maternal care service.
2017 Vol. 24 (13): 167-169转172 [Abstract] ( 117 ) HTML (38 KB)  PDF  (0 KB)  ( 39 )
170 Application and research of positive psychology in the work of providing for the aged
XIAO Xia;GAO Rong;HUANG Wei-ze;LIAO Bo;LI Yan
ObjectiveTo explore the application effect of positive psychology in the work of providing for the aged.Methods83 elderly patients in our hospital from December 2015 to October 2016 were selected as the research object and were randomly divided into intervention group and control group,43 cases were in the intervention group,40 cases were in the control group.The control group was given routine health education and general psychological nursing,the intervention group was given positive psychological intervention on the basis of the control group,two groups of patients at the same time to intervene,the intervention time was 1 month.The life satisfaction scale and patient satisfaction questionnaire were used to evaluate the effect of the two groups.ResultsBefore intervention,there were no significantly different betweeen life satisfaction in two groups(P＞0.05);after intervention,the life satisfaction in two groups were all increased,and compared with those before nursing,the differences were statistically significant(P＜0.05).,and that in the intervention group[(29.48±4.17)points]was higher than that in the control group[(23.26±4.46)points],and the difference was statistically significant(P＜0.05).The nursing satisfaction in the intervention group (95.35%)was higher than that in the control group(82.50%),and the difference was statistically significant(P＜0.05).ConclusionThe use of positive psychology to the positive psychological intervention on elderly patients,is helpful to cultivate the positive psychology of elderly patients,improve the elderly psychological quality and happiness management ability,improve the relationship between nurses and patients,positive impact on quality of life in patients with the.
2017 Vol. 24 (13): 170-172 [Abstract] ( 120 ) HTML (36 KB)  PDF  (0 KB)  ( 36 )
173 Efficacy of peer support interven tion on quality of life of community empty-nest elderly patients with diabetes mellitus
LIN Kai-si;FANG Ting-ting;CHI Li-na
ObjectiveTo explore the efficacy of peer support intervention on improving the quality of life in community empty-nest elderly patients with diabetes mellitus.Methods100 empty-nest elderly patients with diabetes from adjacent communities in Shenzhen were selected in this study from January 2015 to July 2015.The patients were divided into the observation group and the control group according to the random number table method,with 50 cases in each group.Patients in the control group were given routine diabetes health education and guidance,while patients in the observation group were given 6-month peer support intervention on the basis of the control group.The self-management activity,quailty of life,the level of HbA1c and BMI of patients were compared between two groups.ResultsBefore intervention,there were no significantly different among the scores of 5 dimensions of self-management activity in two groups(P＞0.05);after intervention,those in the observation group were increased,and compared with those before intervention,the differences were statistically significant(P＜0.05),but there were no statistically significant differences in the cintrol group between those before and after intervention(P＞0.05).And those in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).Before intervention,there were no significantly different among the score of DSQL and the level of HbA1c and BMI in two groups(P＞0.05);after intervention,those in the observation group were all declined,and compared with those before intervention,the differences were statistically significant(P＜0.05),but there were no statistically significant differences in the cintrol group between those before and after intervention (P＞0.05).And those in observation group was lower than those in control group,and the differences were statistically significant(P＜0.05).ConclusionPeer support intervention can improve Community empty nest elderly diabetes patients′self-management ability,improve their quality of life,effectively control blood glucose fluctuation,and it is worth promoting.
2017 Vol. 24 (13): 173-175转178 [Abstract] ( 138 ) HTML (40 KB)  PDF  (0 KB)  ( 36 )
176 Application of evidence-based nursing in the nursing of patients with severe acute pancreatitis
CHEN Ying-fang
ObjectiveTo explore the Application of evidence-based nursing in the nursing of patients with severe acute pancreatitis.Methods80 patients with severe acute pancreatitis admitted in our hospital from March 2015 to March 2016 were selected as the research objects,and were divided into the observation group and the control group according to the admission time,with 40 cases in each group.Patients in the observation group were given evidence-based nursing intervention,while patients in the control group were given routine nursing intervention.The incidence of complications, nursing satisfaction,bedridden time and hospital stay were compared between the two groups.ResultsThe incidence of complications in the observation group(7.50%)was lower than that in the control group(25.00%),the nursing satisfaction(97.50%)was higher than that in the control group(82.50%),the bedridden time and hospital stay[(3.56±1.25),(7.89± 3.25)d]were shorter than those in the control group[(7.59±3.65),(15.23±3.69)d],and all the differences were statistically significant(P＜0.05).ConclusionGiving evidence-based nursing intervention for patients with severe acute pancreatitis can effectively reduce the incidence of complications,shorten the hospitalization time,improve the degree of nursing satisfaction.It is worthy of clinical application.
2017 Vol. 24 (13): 176-178 [Abstract] ( 116 ) HTML (35 KB)  PDF  (0 KB)  ( 24 )
179 Efficacy of individualized continuation nusing intervention on disease control and quality of life in children with asthmatic
FU Yin-xiang;FENG Chi-guang
ObjectiveTo explore the efficacy of individualized continuation nusing intervention on disease control and quality of life in children with asthmatic.Methods120 children patients with asthmatic treated in our hospital and about to discharged from January 2015 to June 2016 were selected and divided into the control group and the experiment group according to random number table.The control group was given routine discharge care,while the experiment group were given individual continuity of nursing intervention on the basis of the control group.The lung function,treatment compliance,asthmatic attack and quality of life were compared between two groups.ResultsBefore intervention, there were no significantly different among the levels of FEV1,FVC and PEF in two groups(P＞0.05);after intervention, the levels of those in two groups were all increased,and compared with those before intervention,the differences were statistically significant(P＜0.05).And those in the experiment group were higher than those in the control group,and the differences were statistically significant(P＜0.01).The times of asthmatic attack,hospitalization and emergency treatment of patients in the experiment group were less than those in the control group,the treatment compliance was higher than those in the control group,and the differences was statistically significant(P＜0.01).Before intervention,there were no significantly different among the scores of sickness influence,respiratory symptom,activity limitation in two groups(P＞0.05); after intervention,the scores of those in two groups were all reduced,and compared with those before intervention,the differences were statistically significant(P＜0.05).And those in the experiment group were lower than those in the control group,and the differences were statistically significant(P＜0.01).ConclusionIndividualized continuity nursing can improve the treatment compliance of children with asthmatic,effectively control the symptoms of disease and improve the quality of life of children.It is worthy of clinical application.
2017 Vol. 24 (13): 179-182 [Abstract] ( 105 ) HTML (46 KB)  PDF  (0 KB)  ( 35 )
183 Efficacy of early health education on rehabilitation of limb function in patients with cerebral thrombosis
FENG Li-mian;CHAO Shan-shan;PENG Ying-ying;DENG Guo-min;LI Yu-ting
ObjectiveTo explore the efficacy of early health education on rehabilitation of limb function in patients with cerebral thrombosis.Methods280 patients′clinical datas with cerebral thrombosis treated by Department of Neurology in our hospital were selected and divided into the control group(regular nursing on rehabilitation guidance)and the observation group (early health education)according to different nursing measures.The neurological impairment,quality of life before and after nursing,recurrence rate and nursing satisfaction were compared between two groups.ResultsBefore nursing,there was no significantly different among the scores of NIHSS in two groups(P＞0.05);after nursing,the scores of NIHSS in two groups were all declined,and compared with those before nursing,the differences was statistically significant(P＜0.05).And that in observation group was lower than those in control group,and the difference was statistically significant(P＜0.05).Before nursing,there were no significantly different among the scores of indexes of quanlity of life in two groups(P＞0.05);after nursing,those in two groups were all increased,and compared with those before nursing,the differences were statistically significant(P＜0.05).And those in observation group was higher than those in control group,and the differences were statistically significant(P＜0.05).The recurrence rate of patients in the observation group was lower than that in the control group,the nursing satisfaction was higher than that in the control group,and the differences were statistically significant(P＜0.05).ConclusionApplication of early health education in patients with cerebral thrombosis can reduce the score of neurological impairment,improve the quality of life and patients′satisfaction.It is worthy of clinical application.
2017 Vol. 24 (13): 183-185转188 [Abstract] ( 92 ) HTML (40 KB)  PDF  (0 KB)  ( 32 )
186 Application of high quality nursing care in postpartum hemorrhage of pregnant women with pregnancy induced hypertension
YU Long-ying
ObjectiveTo explore application of high quality nursing care in postpartum hemorrhage of pregnant women with pregnancy induced hypertension.Methods110 cases of postpartum hemorrhage maternal with pregnancy induced hypertension in our hospital from June 2012 to June 2014 were selected and were randomly divided into the control group(n=51)and the observation group(n=59).Patients in the control group were given routine nursing,while patients in the observation group were given high quality nursing care on the basis of the control group.The nursing effect of two groups of patients were compared and analyzed.ResultsThe patients in the observation group were significantly better than those in the control group in diastolic blood pressure,systolic blood pressure,quality of life score,visual analogue score and blood pressure control rate,and the differences were statistically significant(P＜0.05).ConclusionThe high quality nursing care for postpartum hemorrhage of pregnant women with high blood pressure can greatly improve their physical fitness,and effective control of blood pressure,can be vigorously promoted in clinical treatment.
2017 Vol. 24 (13): 186-188 [Abstract] ( 112 ) HTML (35 KB)  PDF  (0 KB)  ( 30 )
189 Application of special care combined with rehabilitative guidance in patients with femoral intertrochanteric fracture
LI Hong-li
ObjectiveTo explore the application of special care combined with rehabilitative guidance in patients with femoral intertrochanteric fracture.Methods150 patients′clinical data of femoral intertrochanteric fracture in Department of Orthopaedics in our hospital from March 2014 to September 2016 were selected and divided into the observation group(n=80)and the control group(n=70)by different nursing method.Patients in the control group were given routine nursing,while patients in the observation group were given special care combined with rehabilitative guidance.The score of Harris,the degree of pain after operation and quality of life were compared between two groups.ResultsThe excellent rate of the score of Harris in the observation group was higher than that in the control group,the degree of pain was lower than that in the control group,and the differences were statistically significant(P＜0.05).Before operation,there were no significantly different among the scores of body function,social function,mental health,substance function in two groups (P＞0.05);after operation,the scores of those indexes in two groups were all increased,and compared with those before operation,the differences were statistically significant(P＜0.05).And those in observation group were higher than those in control group,and the differences were statistically significant (P＜0.05).ConclusionThe application of femoral intertrochanteric fracture patients by special care compare with rehabilitative guidance,which could improve hip joint function of patients,decrease pain after operation,increase life quality,it is worthy of clinical application.
2017 Vol. 24 (13): 189-191 [Abstract] ( 117 ) HTML (39 KB)  PDF  (0 KB)  ( 37 )
192 Evaluation of the efficacy of pre-hospital emergency nursing pathways on pre-hospital emergency in stroke patients
WU Dan;ZHU Xue-li
ObjectiveTo evaluate the efficacy of pre-hospital emergency nursing pathways on pre-hospital emergency in stroke patients.Methods130 cases of stroke patients who were treated by 120 in our hospital from January 2015 to December 2016 were selected as the subjectsand were divided into the experiment group and the control group by simple sampling method,with 65 cases in each group.Patients in the control group were given conventional emergency care, while patients in the experiment group were given pre-hospital emergency nursing pathways on the basis of the control group.The time from the call for 120 to pre-hospital emergency and from pre-hospital emergency to the emergency department for treatment,the mortality and morbidity of patients were conpared between two groups.ResultsThe time from the call for 120 to pre-hospital emergency and from pre-hospital emergency to the emergency department for treatment in the experiment group were shorter than those in the control group,the mortality and morbidity of patients were lower than those in the control group,and the differences were statistically significant(P＜0.05).ConclusionThe implementation of pre-hospital emergency care pathways can improve the quality of life of stroke patients,and strive for more rescue gold time.
2017 Vol. 24 (13): 192-194 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 34 )
195 Efficacy of scene simulation exercises on the cardiopulmonary resuscitation in basic-hospital head nurses
CHEN Cai-feng;ZHU Xue-mei;LU Ru-yin
ObjectiveTo explore the efficacy of scene simulation exercises on the cardiopulmonary resuscitation in basic-hospital head nurses.Methods96 basic-hospital head nurses were selected as the research objects who trained in our hospital from June 2016 to December 2016,the nurses were divided randomly into three-personsrescued group and four-personsrescued group,that groups also had a cardiologist,and the cardiologist in every group was the group leader; the nurses were the team menbers.The team menbers were numbered and distributed to different rescued responsibilities.Accordingto the 2015 cardiopulmonary resuscitation guidelines,The nurses were trained with theory knowledge of cardiopulmonary resuscitation、chest compressions、artificial respiration,establishing venous channel by scene simulation exercises,and analysized the changes of observation indexes before and after the train.ResultsAfter the scene simulation exercises train,there were significantly statistical difference(P＜0.05)when comparing with the head nurse′s the total time of cardiopulmonary resuscitation,theoretical knowledge etc.when comparing between the three-personsrescuedgroup and four-personsrescued group,the four-personsrescued group′s scorewere well than the three-personsrescuedgroup′s score,but there were no significant difference between them(P＞0.05).ConclusionThe standardized scene simulation exercises can effectively improve basic-level hospitals head nurse of cardiopulmonary resuscitation comprehensive ability andbusiness level,and it is expected to improve the success rate of the rescue in basic-hospital,it is worth for popularizing in clinic.
2017 Vol. 24 (13): 195-197 [Abstract] ( 133 ) HTML (36 KB)  PDF  (0 KB)  ( 36 )
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