早产儿血清25羟基维生素D3水平与超声骨密度的相关性研究

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Abstract ObjectiveTo investigate the correlation between serum 25-hydroxy vitamin D3levels and bone mineral density in premature infants.Methods76 neonates were born and hospitalized in Xiaolan Hospital Affiliated to Southern Medical University from May 2014 to February 2017.Among them,there were 30 cases of term infants and 46 cases of preterm infants.The basic situation was recorded at birth,The bone mineral density(SOS)of the middle tibia was measured within 24 hours after birth in the preterm infantile and term infants by quantitative ultrasound.The serum 25-hydroxy vitamin D3,parathyroid hormone(PTH),calcium(Ca),phosphorus(P)and alkaline phosphatase(ALP)levels in the preterm infants were measured at the 50th percentile(38 ng/ml)(≥38 ng/ml,26 cases)and preterm children B group(＜38 ng/ml, 20 cases)were analyzed in preterm children and term infants,premature children A group and premature children The difference of the above indexes between group B and the level of plasma vitamin D and the bone mineral density in premature infants.Results①The levels of 25-hydroxy vitamin D3in premature infants were lower than those in term infants(P＜0.01).②The bone mineral density of the tibia in the premature infants group was lower than that in the infants group(P＜0.01).③There was no significant difference in ALP and P between preterm infants and term infants(P＞0.05). There were significant differences in tibial bone mineral density,PTH,calcium ion and 25-hydroxy vitamin D3between group A and group B (P＜0.01),but no significant difference in serum phosphorus and ALP between the two groups(P＞0.05).⑤There was a positive correlation between the level of 25-hydroxy vitamin D3and Ca,tibial bone mineral density and PTH (P＜0.05),and had no correlation with P and ALP (P＞0.05).Conclusion①The density of tibial bone and the content of 25-hydroxy vitamin D3in premature infants were significantly lower than those of term infants.②The bone mineral density of tibial ultrasound in preterm infants with high levels of 25-hydroxy vitamin D3was higher than that of preterm infants with low levels of vitamin D3,Therefore,Supplementation of 25-hydroxy vitamin D3to promote premature infant bone growth,prevention of metabolic bone disease in premature children is important.

Key words： Premature infants Quantitative ultrasound Bone mineral density Serum 25-hydroxy vitamin D3

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	LI Yuan-bin
	LU Mei

Cite this article:

LI Yuan-bin,LU Mei. Research on the correlation between serum 25-hydroxy vitamin D3and ultrasound bone mineral density in premature infants[J]. 中国当代医药, 2017, 24(13): 106-108转126.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I13/106

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