康艾注射液联合FOLFIRI方案治疗结直肠癌的Meta分析

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Abstract ObjectiveTo discuss and systematically evaluate the clinical effect and safety of Kangai Injection combined with FOLFIRI for the treatment of colorectal cancer.MethodsPubmed,the Cochrane Library,SCI,CNKI,VIP,CBM,Wan Fang Database were searched using computer.August 10,2016 was search deadline.Clinical randomized controlled study of Kangai Injection combined with FOLFIRI chemotherapy plan applied in colorectal cancer was collected,and the effective rate,the improvement rate of quality of life and adverse reaction related data among the studies were added and combined.Differences of curative effect of two drug combination group and single FOLFIRI group were compared and analyzed.According to the inclusion and exclusion criteria,two researchers independently selected and searched the literature,extracted the data and Meta analysis was conducted using Revman 5.0 software.ResultsA total of 4 studies were included involving 299 patients.Meta analysis results showed that there was a statistical difference of the effective rate between the Kangai Injection combined with FOLFIRI chemotherapy plan (the combined group)and single FOLFIRI chemotherapy plan group after treatment(P＜0.01;OR=1.82,95%CI=1.16-2.87).There was a statistical difference of the improvement rate of quality of life between the combined group and single FOLFIRI plan (P＜0.01;OR=2.32,95%CI=1.33-4.07).The incidence rate of white blood cell reduction in the combination group was statistically significant lower than that of the single FOLFIRI chemotherapy plan group,and there was a statistical difference(P＜0.01;OR=51.46,95%CI=10.36-255.67).Theincidence rate of nausea and vomiting in the combination group was statistically significant lower than that of the FOLFIRI chemotherapy group and there was a statistical difference(P＜0.01;OR=0.33,95%CI=0.15-0.73).There was no significant difference between the two groups in the aspects of platelet reduction,liver and renal function damage and diarrhea (P＞0.05).ConclusionKangai Injection combined with FOLFIRI chemotherapy plan is better than single FOLFIRI chemotherapy plan in the aspects of effect for treating advanced colorectal cancer and reducing the adverse reaction.

Key words： Kangai Injection FOLFIRI Colorectal cancer Meta-analysis

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	Articles by authors
	ZHANG Li-na
	WANG Yuan-yuan
	QIU Chao-ping
	SU Ting
	YE Hui
	SHI Xian-fang

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ZHANG Li-na,WANG Yuan-yuan,QIU Chao-ping, et al. Meta analysis of Kangai Injection combined with FOLFIRI for the treatment of colorectal cancer[J]. 中国当代医药, 2017, 24(13): 4-8转19.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I13/4

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