68例女性精神病患者闭经临床分析

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Abstract ObjectiveTo explore the etiology and treatment of amenorrhea of female psychotic patients treated with various antipsychotic medications.MethodsRetrospective analysis of the data of 68 cases of amenorrhea female psychotic patients who visited the gynecology clinic or hospitalized in our hospital and were treated with various antipsychotic medications from June 2012 to December 2016.All the data,including the results of measurement of sex hormones(PRL, FSH,LH,E2,P and T)levels and results of ultrasonic inspection(uterus,accessories and endometrial thickness),were collected.ResultsIt was found from the analysis of these data that there were 12 cases of patients with normal level of sex hormones and normal results of ultrasonic inspection(17.64%),46 cases with Antipsychotic-induced hyperprolactinemia(HPRL)(67.64%),8 cases with higher level of follicle stimulating hormone(6 cases FSH＞10 IU；2 cases FSH＞40 IU)(11.76%) and 2 cases with higher level of PRL and FSH(2.94%).Resultsof ultrasonic inspection indicated that there were 51 cases of patients with normal of uterine and adnexal(75.00%),9 cases with uterus polyp(13.20%),3 cases with ovary cyst(7.00%), 5 cases with polycystic ovary (17.60%).There were 22 cases of patients with the thickness of endometrial≤5 mm (32.30%),38 cases with the thickness of endometrial between 5 mm (55.80%)and 10 mm and 8 cases with the thickness of endometrial≥10 mm (11.70%).ConclusionIt can be claimed from the analysis of these data that the main etiology of amenorrhea female psychotic patients is relative to their state of the nervous tension,stress,depression,anxiety and antipsychotic medications which they take,except to the natural decrease of function of ordinary ovary and the change of polycystic ovary.Thence,sex hormones measurement and ultrasonic inspection should be exerted as the periodic and routine screening program in the clinical application for amenorrhea of female psychotic patients treated with various antipsychotic medications in a considerable long term of time.

Key words： Amenorrhea Female psychotic patient Antipsychotics Etiology Treatment

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	YU Yun-xiang
	LI Yu-chun
	LI Xue-mei

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YU Yun-xiang,LI Yu-chun,LI Xue-mei. Clinical analysis of 68 female psychotic patients with amenorrhea[J]. 中国当代医药, 2017, 24(13): 109-111.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I13/109

[1]	张薇.抗精神病药物致女性患者闭经的临床研究[J].中国民康医学，2012，24（14）：1700.
[2]	罗维肖，刘姝婷，甘少兵等.精神科门诊患者药源性闭经调查[J].临床精神医学杂志，2011，21（3）：199-200.
[3]	徐小花，郭建雄，杨永连.抗精神病药物对女性患者内分泌系统的影响[J].国际医药卫生导报，2015，21（3）：373-375.
[4]	中华医学会妇产科学分会内分泌学组，田秦杰.闭经诊断与治疗指南(试行)[J].中华妇产科杂志，2011，46（9）：712-716.
[5]	邬舟艳，张景明，杜荣荣.抗精神病药物所致闭经患者子宫内膜厚度测定及孕激素治疗临床观察[J].浙江中西医结合杂志，2014，24（3）：246-247.
[6]	罗雪珍，林金芳.高泌乳素血症对女性的不良影响[J].实用妇产科杂志，2016，7（32）：483-484.
[7]	张敏，谷伟，邓克文，等.不同抗精神病药物对精神分裂症患者血清性激素水平的影响[J].临床医学研究与实践，2016，13（1）：6-9.
[8]	于文娟，朱丽萍.抗精神病药物引起高催乳素血症的机制[J].精神医学杂志，2011，24（3）：235-237.
[9]	王佳宁，阮祥燕.高泌乳素血症的病因及诊疗进展[J].医学综述，2012，18（21）：3629-3632.
[10]	迟勇.氨磺必利与利培酮对女性精神分裂症患者血清催乳素的影响研究[J].中国医刊，2016，51（2）：92-95.
[11]	何文，陈林俊，刘真文，等.抗精神病药所致高泌乳素血症的临床分析[J].实验与检验医学，2014，32（4）：436-437.
[12]	孙振晓，于相芬.抗精神病药物所所致高催乳素血症研究进展[J].药物不良反应杂志，2012，14（3）：154-159.
[13]	蒋特成，刘成文，蔡端芳，等.抗精神病药物对女性精神病患者血清催乳素与腹部脂肪沉积的影响[J].实用药物与临床，2015，18（4）：474-477.
[14]	周平，刘联琦，郝军锋，等.阿立哌唑预防女性精神分裂症患者抗精神病药物所致高泌乳素血症研究[J].国际精神病学杂志，2014，41（2）：68-72.
[15]	中华医学会妇产科学分会内分泌学组.《女性高催乳素血症诊治共识》发布[J].中华妇产科杂志，2016，51（3）：161-168.
[16]	田倩玉，杨欣.无妊娠要求的高泌乳血症治疗策略及监测[J].实用妇产科杂志，2016，32（7）：487-489.
[17]	李晓玲，赵长江，罗庆新，等.抗精神病药物对泌乳素的影响和不同分子量泌乳素与临床症状的关系[J].神经疾病与精神卫生，2015，15（4）：398-402.
[18]	吴南顺.围绝经期抑郁激素替代疗法的研究进展[J].中国医药导报，2016，13（6）：40-41.
[19]	郑燕伟，陶敏芳.围绝经期女性睡眠障碍的研究进展[J].上海交通大学学报，2016，36（7）：1088-1091.
[20]	洪宇，彭瑾，谢梅青.围绝经期情绪障碍诊断与治疗的研究进展[J].实用妇产科杂志，2011，27（9）：658-660.