|
|
|
| Effect of Gabapentin in the treatment of intractable pruritus in hemodialysis patients |
| YU Lan |
| Department of Nephrology,Ezhou Second Hospital of Hubei Province,Ezhou 436000,China |
|
|
|
|
Abstract ObjectiveTo explore the effect of gabapentin in the treatment of hemodialysis patients with intractable pruritus.Methods86 cases of hemodialysis with intractable pruritus from September 2014 to December 2015 in our hospital were selected and randomly divided into the reference group and the study group,43 cases in each group.All the subjects were given hemodialysis 2 to 3 times a week,and the frequency of irrigation was about 2 times per month. The reference group was given Loratadine,10 mg daily,and the study group was given 0.1 to 0.3 mg Gabapentin in the evening after each dialysis.After 3 months of treatment,the VAS score and the VAG score of the two groups were recorded,the therapeutic effect was evaluated,and the adverse reactions was observed.ResultsThere was no significant difference between the two groups before treatment in the score of VAS,VAG (P＞0.05).The VAS and VAG scores after treatment of the two groups were lower than that before treatment,with significant difference(P＜0.05).The scores of VAS and VAG of the study group was lower than that of the reference group,with significant difference (P＜0.05).2 patients had mild nausea after treatment with gabapentin,did not immediately stop,7 days later,the symptoms disappeared,and no other adverse reactions.ConclusionGabapentin used a small dose of a short period of time will help to improve the hemodialysis patients with pruritus symptoms,improve the sleep quality of patients,the effect is significant,safe and reliable,but a long time use and long-term effect still needs to be further researched.
|
|
|
|
|
|
| [1] |
李峥峻，杨定平.高通量血液透析联合加巴喷丁治疗终末期肾病并发皮肤瘙痒症的临床疗效研究[J].检验医学与临床，2015，12（4）：449-451.
|
| [2] |
李华，吴扬，位红兰.加巴喷丁治疗维持性血液透析患者皮肤瘙痒的疗效和安全性[J].中国新药与临床杂志，2015，34（7）：541-544.
|
| [3] |
陈泽君，曹舸，王平.加巴喷丁治疗尿毒症患者皮肤瘙痒症的Meta分析[J].四川医学，2015，36（12）：1643-1647.
|
| [4] |
曾伟平，严丽萍，柳清.加巴喷丁治疗血液透析患者皮肤瘙痒并改善睡眠质量的临床研究[J].山西医药杂志，2015，14（23）：2793-2794.
|
| [5] |
仰珈仪，赵敬军.加巴喷丁在皮肤病治疗中的应用[J].中国麻风皮肤病杂志，2015，31（12）：730-732.
|
| [6] |
王强，周维肖，黄文.不同剂量加巴喷丁术前用药对气管插管血流动力学的影响[J].广西医科大学学报，2014，31 （2）：293-295.
|
| [7] |
张庆宏.黄芪桂枝五物汤加味合加巴喷丁治疗尿毒症不安腿综合征[J].世界最新医学信息文摘（连续型电子期刊），2015，15（90）：126.
|
| [8] |
刘雷，李良志，汤跃武，等.加巴喷丁联合甲钴胺治疗血液透析患者尿毒症性周围神经病变[J].中国新药与临床杂志，2015，34（4）：302-305.
|
| [9] |
邵宁，孙治华，柳林伟，等.加巴喷丁联合血液透析滤过治疗尿毒症不宁腿综合征[J].医学综述，2015，21（1）：160-162.
|
| [10] |
马聪，吕睿婷，回妍.加巴喷丁联合组合型人工肾对血液透析患者皮肤瘙痒的疗效观察[J].中国冶金工业医学杂志，2016，33（2）：203-204.
|
| [11] |
姚颖嘉，高春芳，黄华，等.加巴喷丁治疗老年顽固性皮肤瘙痒的临床研究[J].世界临床药物，2016，37（3）：190-193.
|
| [12] |
李新伦，黄志芳，高卓，等.加巴喷丁与血液透析滤过改善皮肤瘙痒疗效比较观察[J].人民军医，2014，57（2）：541-544.
|
| [13] |
张建朋，胡青，林京莲，等.口服加巴喷丁与血液透析联合血液灌流治疗血透皮肤瘙痒的疗效对比分析[J].中国中西医结合肾病杂志，2014，15（2）：168-169.
|
| [14] |
钟先阳，陈淑娟，谭江平，等.血液灌流联合多种药物治疗透析患者不安腿综合征远期疗效观察[J].中国中西医结合肾病杂志，2016，17（12）：1067-1069.
|
| [15] |
朱军，叶新荣，庄志清，等.针刺联合加巴喷丁治疗紧张性头痛患者的疗效及对血液流变学的影响观察[J].中国药师，2017，20（2）：290-292.
|
|
|
|
