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2020 Vol. 27, No. 3
Published: 2020-01-28
 
 
4 Protective effect of Chinese medicine Jasmine combined with remote ischemic postconditioning on myocardium in rats with acute myocardial infarction
LUAN Hai-rong; DAI Hai-bing; WANG Han; WU Hong; ZHENG Xue-zhi
Objective To explore the synergistic protective effect of Chinese medicine Jasmine combined with remote ischemic postconditioning (RIPOC) on myocardium in rats with acute myocardial infarction.Methods Forty-six clean SD rats were used to replicate the model of acute myocardial infarction and randomly divided into four groups, namely the model group (n=10), the Chinese medicine Jasmine group (n=12), the RIPOC group (n=12) and the combined group(Chinese medicine Jasmine+RIPOC) (n=12).Another 10 healthy SD rats were selected as the sham operation group.Cardiac function indicators (left ventricular ejection fraction [LVEF], left ventricular end-systolic volume [LVESV], and left ventricular end-diastolic volume [LVEDV]) were measured by echocardiography, cardiac weight index (HWI) and left ventricular mass index (LVMI) were calculated by weighing, and the contents of malondialdehyde (MDA) and superoxide dismutase (SOD) in myocardial tissue were detected.Results The LVEF and content of SOD in the Chinese medicine Jasmine group, RIPOC group and combined group were higher than those in the model group, the LVESV,LVEDV, HWI, LVMI and content of MDA were lower than those in the model group, and the differences were statistically significant (P<0.05 or P<0.01).The LVEF of the model group was lower than that of the sham operation group,HWI and LVMI were higher than those of the sham operation group, and the differences were statistically significant(P<0.01).The MDA content in the model group was higher than that in the sham operation group, the SOD content was lower than that in the sham operation group, and the differences were statistically significant (P<0.01).Conclusion Chinese medicine Jasmine combined with RIPOC has a synergistic effect on the protection of cardiac function and ventricular remodeling in rats with acute myocardial infarction, which is worth promoting.
2020 Vol. 27 (3): 4-7 [Abstract] ( 113 ) HTML (39 KB)  PDF  (0 KB)  ( 10 )
8 Efficacy and safety of radioactive seed localization and versus wire-guided localization guiding the resection of non-palpable breast cancer lesions：a Meta-analysis
ZHANG Mao-quan； XIAO Jian； CHEN Wen-xin； WANG He-bing； YANG Bing-lin； CHEN Ji-cheng
Objective To systematically review the efficacy and safety of radioactive seed localization (RSL) and versus wire-guided localization (WGL) guiding the resection of the non-palpable breast cancer lesions.Methods Databases of CNKI, Web of Science, PubMed, EMBASE, OVID, EBSCO and Cochrane Library were searched by computer, and the retrieval time was from the database construction to March 1, 2019.Meta-analysis was conducted by RevMan 5.3 after the quality of studies was evaluated.Results A total of 13 studies were included，the positive rate of incised margin and the rate of reoperation in the RSL group were lower than those in the WGL group, the differences were statistically significant (OR=0.79, 95%CI 0.68-0.92, P=0.002; OR=0.71, 95%CI 0.59-0.84，P＜0.0001].There was no significant difference in the intra-operative re-excision rate and postoperative complication rate between two groups (OR=0.85,95%CI 0.68-1.07, P=0.16; OR=1.40, 95%CI 0.86-2.27, P=0.18).Conclusion Compared with WGL, RSL has lower rate of positive excision margins rate and reoperation rate, and may have a wider application prospect in the future.
2020 Vol. 27 (3): 8-11转16 [Abstract] ( 113 ) HTML (39 KB)  PDF  (0 KB)  ( 12 )
12 esearch progress on risk factors related to refractory Mycoplasma pneumoniae pneumonia
LIU Xiao-mei； JING Shu-jun
Mycoplasma pneumoniae pneumonia accounts for 10%-40% of children′s community-acquired pneumonia.Among them, the incidence of refractory Mycoplasma pneumoniae pneumonia is increasing year by year, which often leads to serious intrapulmonary and extrapulmonary complications, such as necrotic pneumonia, etc., and is easy to leave sequelae such as occlusive bronchiolitis, atelectasis, bronchiectasis, etc., which seriously threaten children′s health.This article summarizes the risk factors that easily progress to refractory Mycoplasma pneumoniae pneumonia from five aspects： clinical features, imaging, laboratory examination, bronchoscopy and existing diseases.
2020 Vol. 27 (3): 12-16 [Abstract] ( 104 ) HTML (49 KB)  PDF  (0 KB)  ( 16 )
17 Research advances of Apatinib in the treatment of malignant tumor
ZUO Quan； XIANG Zhi-bi
In recent years, the application of molecular targeting therapy in the treatment of malignant tumors has increased rapidly, which is considered to be an effective way to treat malignant tumors.Vascular endothelial growth factor and its receptors play important roles in tumor neovascularization,which is closely related to tumor growth and metastasis.Apatinib Mesylate is a new type of anti-angiogenic drug, which can inhibit tumor angiogenesis and the growth of tumor by highly selective binding and inhibition of vascular endothelial growth factor-2 (VEGF-2).Apatinib Mesylate has considerable objective response rate and survival benefit in several clinical studies of gastric cancer and non-small cell lung cancer and has been approved for the treatment of advanced gastric cancer in 2014.At present, the clinical researches on Apatinib in the treatment of gastric cancer, lung cancer, colorectal cancer and other tumors are being actively carried out, which is hoping to provide a new choice for the treatment of malignant tumors.
2020 Vol. 27 (3): 17-20 [Abstract] ( 118 ) HTML (40 KB)  PDF  (0 KB)  ( 15 )
21 Research progress on the treatment and nursing of epilepsy
GU Qiao
Epilepsy is commonly known as "sheep epilepsy”, which is a common chronic nervous system disease.Epilepsy is recurrent and difficult to cure, and its death and disability rates remain high.Therefore, an in-depth analysis of the pathophysiological mechanism of epilepsy and a timely and effective exploration of a better method to treat epilepsy are the key issues that clinicians urgently need to solve.This article according to clinical practice and combining with the latest research results, discussed the main etiology and pathogenesis of epileptic seizures is further epilepsy treatment and care a variety of methods and measures (Du meridian acupuncture cure epilepsy, eliminating phlegm to extinguish wind treat epilepsy, combination of acupuncture and western medicine treatment, family and the integration of hospital care, etc.) of the latest research progress are reviewed.
2020 Vol. 27 (3): 21-24 [Abstract] ( 88 ) HTML (40 KB)  PDF  (0 KB)  ( 15 )
25 Effect of Duhuojisheng Decoction on immune function of collagen induced arthritis rats
LI Hao； YUAN Yu-ying； JIA Yuan-yuan； LI Xin-ran； ZHANG Zheng-wu； GUAN Jie
Objective To explore the effect of Duhuojisheng Decoction on the immune function of collagen induced arthritis (CIA) rats.Methods A total of 50 clean male Wistar rats were fed adaptively for 7 days, six rats were randomly selected as the normal group, the other rats were injected with 200 μl collagen emulsion into the skin of the left plantar part of their feet to make CIA rat model.Arthritis index(AI)≥4 was used as the model successfully.The model rats were randomly divided into model group,Celecoxib(0.05 g/[kg·d])group,Duhuojisheng Decoction high concentration (44 g/[kg·d])group, Duhuojisheng Decoction medium concentration (22 g/[kg·d]) group and Duhuojisheng Decoction low concentration (11 g/[kg·d]) group, The control group and model group were treated with distilled water of equal volume, once a day, and gavage for 30 days.The levels of T cell specific transcription factor (T-bet), interleukin-2 (IL-2), interferon-γ(IFN-γ), GATA binding protein 3 (GATA-3), interleukin-6 (IL-6) and interleukin-13 (IL-13) in serum of six groups of rats were detected and compared by double antibody sandwich enzyme-linked immunosorbent assay (ABC-ELISA).Results The levels of T-bet, IL-2 and IFN-γ in serum of the model group were higher than those of the normal group,and the levels of GATA-3, IL-6 and IL-13 were lower than those of the normal group, the differences were statistically significant (P<0.05).The T-bet level of Celecoxib group and Duhuojisheng Decoction low, medium and high concentration group were lower than those of model group, the level of IL-2 in Celecoxib group and Duhuojisheng Decoction medium group were lower than those in model group, the IFN-γ levels of Celecoxib group, Duhuojisheng Decoction low and medium concentration group were lower than those of model group, the levels of GATA-3, IL-6 and IL-13 in Celecoxib group, Duhuojisheng Decoction low, medium and high concentration group were higher than those in model group, the differences were statistically significant (P<0.05).Conclusion Duhuojisheng Decoction can exert ideal therapeutic effect on CIA rats.Its anti-inflammatory mechanism is to reduce T-bet levels, increase GATA-3 levels, and suppress immune inflammatory factor levels by regulating the Th1 / Th2 cell balance.
2020 Vol. 27 (3): 25-27转38 [Abstract] ( 95 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
28 Study on repeatability and correctness of digital reading in pathological diagnosis
TANG Zhong-ping; CUI Quan-zhe; BAO Ji; CAI Wei; ZHAO Chun
Objective To investigate the repeatability and correctness of digital reading in clinical pathological diagnosis.Methods A total of 300 consecutive cases in Pathology Department of Chengdu First People′s Hospital diagnosed in September 2015 were chosen as research objects and all the slices were applied with digital scanning by whole slide images (WSI).The author reviewed slices again and made the first digital diagnosis, the second microscopic diagnosis, the second digital diagnosis separately in November 2015, January 2016 and March 2016.The four diagnosis results at different times and in different ways were compared, and the repeatability and correctness of digital reading in clinical pathological diagnosis was analyzed.Results Just as microscopic diagnosis, digital diagnosis had high repeatability and correctness in the nature and types of lesions.Compared with the coincidence rate of the first digital diagnosis and microscopic diagnosis, the coincidence rate of the second digital diagnosis and microscopic diagnosis was significantly higher.Whether it was microscopic or digital reading, the correctness of re-diagnosis of difficult cases was higher than that of initial diagnosis.Conclusion Digital reading has high repeatability and correctness in clinical pathological diagnosis.With the gradual adaptation of pathologists to digital reading, digital diagnosis will be more and more close to, or even beyond microscopic diagnosis in the repeatability and correctness.
2020 Vol. 27 (3): 28-31 [Abstract] ( 107 ) HTML (38 KB)  PDF  (0 KB)  ( 14 )
32 Analysis of related factors affecting the diagnosis and pathological upgrading of atypical endometrial hyperplasia
ZHANG Yue-hua; WANG Lu-yi; ZHANG Se-hua
Objective To analyze the related factors affecting the diagnosis and pathological upgrading of atypical endometrial hyperplasia (AEH).Methods The clinical data of 88 patients with AEH who were initially diagnosed in the Department of Gynecology of Foshan First People′s Hospital in Guangdong Province from December 2015 to December 2018 were retrospectively analyzed.According to the results of postoperative pathological diagnosis, the patients were divided into endometrial carcinoma (EC) group (31 cases) and AEH group (57 cases).The related factors of AEH pathological upgrading were analyzed.Results There was no significant difference in the level of high-density lipoprotein(HDL-C) and hypertension between the two groups (P＞0.05).The age and endometrial thickness of patients in the EC group were higher than those in the AEH group, and triglycerides (TG), total cholesterol (CHOL), low-density lipoprotein (LDL-C), body mass index (BMI), menopausal rate, and diabetes incidence were higher than those in AEH group,the differences were statistically significant (P＜0.05).Age≥50 years old (β=1.05, OR=2.88, 95%CI 1.11-7.62), BMI＞25 kg/m2(β=1.35, OR=3.96, 95%CI 1.27-12.66), menopausal status (β=2.72, OR=15.59, 95%CI 2.04-118.52), diabetes(β=1.62, OR=5.97, 95%CI 2.75-16.32), endometrial thickening (β=1.12, OR=3.49, 95%CI 0.76-6.33) and abnormal lipid metabolism (β=1.79, OR=6.13, 95%CI 2.04-17.92) were the risk factors of postoperative pathological progression to EC in patients with AEH (P＜0.05).Conclusion Women over 50 years old (especially in menopause), with symptoms such as abnormal uterine bleeding, dyslipidemia, endometrial thickening, obesity, diabetes and so on, have a higher probability of pathological upgrading to EC in patients with AEH.It is suggested that hysteroscopic assisted curettage should be used.If necessary, pathological examination should be frozen quickly to reduce the rate of missed diagnosis or misdiagnosis, so as to correctly diagnose and treat patients as early as possible.
2020 Vol. 27 (3): 32-34 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
35 Clinical effect comparison of Budesonide Suspension for Inhalation and Budesonide Powder for Inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease
XIAO Li-qi; LI Xiao-yun; LIU Yun; DONG Yong-hai
Objective To explore the clinical effect difference of Budesonide Suspension for Inhalation and Budesonide Powder for Inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD), and to provide reference for clinical treatment of acute exacerbation of COPD.Methods A total of 120 patients with acute exacerbation of COPD admitted to the Department of Respiration of Jiangxi Provincial People′s Hospital from January to December 2018 were selected as subjects in the study.Both groups were given basic treatment.On this basis, patients in the Pulmicort Respulas group were treated with Budesonide Suspension for Inhalation, while patients in the Pulmicort Turbuhaler group were treated with Budesonide Powder for Inhalation.Blood gas analysis indexes (blood oxygen saturation [SpO2], partial pressure of carbon dioxide [PCO2], pH value, HCO3-) of the two groups were compared on the 1st and 7th day of admission, and the repeated hospitalization rates of the two groups within 3 months of discharge were compared.Results On the 1st and 7th day of admission, SpO2, PCO2, pH value and HCO3- of the patients in the two groups were compared, and the differences were not statistically significant (P＞0.05).On the 7th day of admission, SpO2,pH value and HCO3- of patients in the two groups were higher than those on the 1st day of admission, with statistically significant differences (P＜0.05).On the 7th day of admission, PCO2 of both groups were lower than those of this group on the 1st day of admission, with statistically significant differences (P＜0.05).There was no significant difference between the two groups in the repeated hospitalization rate within 3 months after discharge (P＞0.05).Conclusion Budesonide Suspension for Inhalation and Budesonide Powder for Inhalation have good therapeutic effect on acute exacerbation COPD and are worthy of clinical application.
2020 Vol. 27 (3): 35-38 [Abstract] ( 117 ) HTML (39 KB)  PDF  (0 KB)  ( 12 )
39 Clinical effect of Thymosin combined with Bromhexine Hydrochloride in the treatment of pulmonary infection secondary to chronic obstructive pulmonary disease in elderly patients
YUAN Hua-bao； LU Yu-lin； WEN Xiang-fei
Objective To investigate the clinical effect of Thymosin combined with Bromhexine Hydrochloride in the treatment of pulmonary infection secondary to chronic obstructive pulmonary disease (COPD) in the elderly patients.Methods A total of 78 patients with COPD admitted to our hospital from October 2017 to October 2018 were selected as the study objects.They were divided into two groups by random number table method, with 39 cases in each group.The control group was treated with Bromhexine Hydrochloride, and the analysis group was treated with Thymosin combined with Bromhexine Hydrochloride.The total effective rate of clinical treatment, occurrence of adverse reactions,lung function indicators (forced expiratory volume in 1 second [FEV1], forced exhalation in 1 second/forced vital capacity [FEV1/FVC]) and blood gas analysis indicators (partial blood carbon dioxide pressure [PaCO2], partial blood oxygen pressure [PaO2]) of the two groups were compared.Results The total effective rate of the analysis group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).After treatment, FEV1 and FEV1/FVC in the analysis group were higher than those in the control group, with statistically significant differences (P＜0.05).After treatment, the PaO2 in the analysis group was higher than that in the control group, and the difference was statistically significant (P＜0.05).After treatment, PaCO2 in the analysis group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The combination of thymosin and bromhexine hydrochloride in elderly patients with pulmonary infection secondary to COPD can promote the recovery of patients more effectively,worthy of clinical application
2020 Vol. 27 (3): 39-41转57 [Abstract] ( 106 ) HTML (39 KB)  PDF  (0 KB)  ( 15 )
42 Application effect of early intensive functional exercise in elderly patients after femoral intertrochanteric fracture surgery
GE Ling； WU Jun
Objective To observe the application effect of early intensive functional exercise in elderly patients after femoral intertrochanteric fracture surgery.Methods A total of 50 elderly patients with femoral intertrochanteric fractures treated in Orthopaedics Department of Yudu County People′s Hospital from April 2017 to September 2018 were selected as the research subjects.According to the random number table method, they were divided into the control group (25 cases) and the observation group (25 cases).The control group received routine rehabilitation, and the observation group received early intensive functional exercise.The rehabilitation effect, hip function scale (Harris), daily living ability (Barthel index), visual analogue scale (VAS), and life quality (GQOL-74) scores before and after intervention were compared between the two groups.Results The total effective rate of rehabilitation in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The Harris score of patients in the observation group after intervention was higher than that in the control group, and the difference was statistically significant (P＜0.05).The Barthel index score after intervention in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The life quality score of patients in the observation group after intervention was higher than that in the control group, and the difference was statistically significant(P＜0.05).The VAS score of patients in the observation group after intervention was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Early intensive functional exercise in the elderly after femoral intertrochanteric fracture can improve the rehabilitation effect of patients, promote functional recovery, reduce patients′ pain, improve their daily living ability and quality of life, with good effect, which is worthy of reference.
2020 Vol. 27 (3): 42-45 [Abstract] ( 93 ) HTML (38 KB)  PDF  (0 KB)  ( 10 )
46 Risk factors analysis of carotid atherosclerosis in patients with alcoholinduced mental disorders
WANG Xiao-yun； YANG Fan； HUANG Li
Objective To investigate the status and risk factors of carotid atherosclerosis in patients with alcohol- induced mental disorder.Methods A total of 158 patients with alcohol-induced mental disorder who were admitted to our hospital from September 2016 to February 2018 were selected as subjects.Carotid ultrasonography was performed to detect the carotid intima media thickness (IMT) and the occurrence of plaque.According to the IMT patients with alcohol-induced mental disorders were divided into carotid atherosclerosis group (n=68) and carotid artery normal group(n=90).The occurrence of carotid atherosclerosis in this study was statistically analyzed.The clinical data and biochemical indexes of carotid atherosclerosis group and normal carotid artery group were compared.The influencing factors were further analyzed by multivariate Logistic regression.Results The detection rate of carotid atherosclerosis in patients with alcohol-induced mental disorders was 43.0%.The age of the carotid atherosclerosis group was higher than that of the normal carotid group, course of diseases was longer than that of the normal carotid group, fasting blood sugar was higher than that of the normal carotid group, low density lipoprotein cholesterol (LDL-C) level was lower than that of the normal carotid group, proportions of hypertension and smoking were higher than those of the normal carotid group, the alcohol consumption was more than the normal carotid group, the drinking time was longer than normal carotid artery group, the differences were statistically significant (P＜0.05).There was no significant difference in gender between the two groups (P＞0.05).The results of multivariate Logistic regression analysis suggested that lipid metabolism disorder (β=0.358, OR=1.716, 95%CI=1.501-1.996), hypertension (β=0.356, OR=1.427, 95%CI=1.202-1.786),smoking (β=0.864, OR=2.563, 95%CI=1.777-3.334), hyperglycemia (β=0.663, OR=1.977, 95%CI=1.001-3.801), alcohol consumption (β=0.596, OR=1.466, 95%CI=1.233-1.697), drinking time (β=0.184, OR=1.038, 95%CI=1.006-1.986)were risk factors for carotid atherosclerosis in patients with alcohol-induced mental disorders (P＜0.05).Conclusion Carotid ultrasound can detect atherosclerotic lesions in patients with alcohol-induced mental disorders, especially among elderly patients with high alcohol consumption, and high blood lipid levels in their early carotid artery screening,and provide objective basis for preventing cardiovascular and cerebrovascular diseases.
2020 Vol. 27 (3): 46-49 [Abstract] ( 102 ) HTML (35 KB)  PDF  (0 KB)  ( 12 )
50 Clinical effect of early goal-directed therapy in the treatment of septic shock under guidance of plasma colloid osmotic pressure
ZHONG Xue-fei
Objective To observe the clinical effect of early goal-directed therapy (EGDT) in the treatment of septic shock under guidance of plasma colloid osmotic pressure (PCOP).Methods A total of 70 patients with septic shock who were treated in our hospital from March 2017 to March 2018 were enrolled.They were divided into control group and observation group by random number method, 35 cases in each group.The control group was given routine EGDT,while observation group was given EGDT under guidance of PCOP.The acute physiology and chronic health evaluation(APACHE II) scores before treatment and after 24 hours treatment were compared between the two groups.The lactate clearance rates at 6, 12 and 24 h after treatment were compared between the two groups.The ICU indwelling time,mortality and incidence of multiple organ dysfunction syndrome (MODS) were compared between the two groups.Results After 24 hours treatment, APACHE II score of observation group was lower than that of control group.At 6, 12 and 24 h after treatment, clearance rate of lactate in observation group was higher than that in control group (P＜0.05).ICU indwelling time in observation group was shorter than that in control group, 14 d mortality rate and incidence of MODS were lower than those in control group (P＜0.05).Conclusion EGDT in treatment of septic shock under PCOP guidance can shorten ICU indwelling time, reduce 14 d mortality rate and incidence of MODS.
2020 Vol. 27 (3): 50-52 [Abstract] ( 77 ) HTML (33 KB)  PDF  (0 KB)  ( 16 )
53 Effect comparison of GnRHa and Mifepristone in the pretreatment of laparoscopic myomectomy
LUO Qiong; WU Yu-qiang
Objective To investigate the effect of gonadotropin releasing hormone analogue (GnRHa) and Mifepristone in the pretreatment of laparoscopic myomectomy.Methods A total of 50 patients who underwent laparoscopic myomectomy in our hospital from January 2016 to March 2018 were randomly selected as study subjects.The patients were divided into the experimental group and the control group according to order of single and double numbers of patients admitted to hospital, with 25 cases in each group.The control group was pretreated with GnRHa, while the experimental group was pretreated with Mifepristone, then patients in both groups were treated with laparoscopic myomectomy.The recurrence rate of uterine fibroids, estrogen receptor (ER), progesterone receptor (PR), Ki-67 protein positive rates,clinical treatment effect, perioperative indicators (intraoperative blood loss, operation time, hospitalization time) and diameter of uterine fibroids before and after medication were observed in the two groups.Results The recurrence rate of uterine fibroids in the experimental group (4.00%) was lower than that in the control group (24.00%), and the difference was statistically significant (P＜0.05).The diameter of uterine fibroids in the experimental group ([1.31±0.34]cm) after medication was smaller than that in the control group ([3.21±0.22]cm), with statistically significant difference (P＜0.05).The protein positive rates of ER (64.00%), PR (48.00%), and Ki-67 (28.00%) in the uterine fibroids of the experimental group were respectively lower than those of the control group (88.00%, 80.00%, and 60.00%), with statistically significant differences (P＜0.05).The intraoperative blood loss in the experimental group ([87.62±14.38]ml) was less than that in the control group ([102.87±15.29]ml), with statistically significant difference (P＜0.05).The operation time([56.29±5.71]min) and hospitalization time ([4.27±0.72]d) of the experimental group were shorter than those of the control group ([107.32±5.28]min, [6.21±0.11]d), with statistically significant differences (P＜0.05).The total effective rate of clinical treatment of patients in the experimental group was 96.00%, which was higher than that in the control group accounting for 72.00%, and the difference was statistically significant (P＜0.05).Conclusion Compared with Gn-RHa, the use of Mifepristone in patients with uterine fibroids is beneficial to reduce the expression levels of ER, PR and Ki-67 proteins in tumor tissues, reduce the volume of fibroids and reduce the recurrence rate of fibroids.The clinical effect of Mifepristone is higher than that of GnRHa, which is worthy of wide clinical promotion and application.
2020 Vol. 27 (3): 53-57 [Abstract] ( 95 ) HTML (42 KB)  PDF  (0 KB)  ( 11 )
58 Clinical effect of Moxifloxacin combined with Mycobacterium vaccae in the treatment of patients with multidrug-resistant pulmonary tuberculosis and its influence on immunity
LI Xue-hua
Objective To explore the clinical effect of Moxifloxacin combined with Mycobacterium vaccae in the treatment of patients with multidrug-resistant pulmonary tuberculosis and its influence on immune function.Methods One hundred patients with multidrug-resistant pulmonary tuberculosis admitted to our hospital from March 22, 2017 to March 22, 2018 were selected as subjects, they were divided into observation group and control group by database random grouping method, with 50 cases in each group.The observation group was treated with Moxifloxacin combined with Mycobacterium vaccae, and the control group was treated with conventional chemotherapy.The indicators of T lymphocyte 8 (CD8+), T lymphocyte 4 (CD4+), CD4+/CD8+, T lymphocyte 3 (CD3+), serum interleukin-1 (IL-1), serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), total effective rate, sputum negative conversion rate 6 months after treatment, and sputum negative conversion rate 12 months after treatment were compared between the two groups.Results In the observation group, CD4+/CD8+was (1.98±0.24), the level of CD8+was (28.75±2.41)%, the level of CD4+was(42.57±4.31)%, the level of CD3+was (69.12±4.19)%, sputum negative conversion rate of 6 months after treatment was 64.00%, sputum negative conversion rate of 12 months after treatment was 92.00% and the total effective rate was 96.00%.In the control group, CD4+/CD8+was (1.19±0.05), the level of CD8+ was (26.13±1.35)%, the level of CD4+ was(36.28±3.66)%, the level of CD3+was (62.45±3.26)%, sputum negative conversion rate of 6 months after treatment was 40.00%, sputum negative conversion rate of 12 months after treatment was 68.00%, and the total effective rate was 68.00%.The indicators of CD4+/CD8+, CD8+, CD4+, CD3+, sputum negative conversion rate of 6 months after treatment,sputum negative conversion rate of 12 months after treatment and total effective rate in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).In the observation group,the levels of IL-1, IL-6, and TNF-α were (18.53±2.39), (152.39±12.19) and (85.23±3.11) ng/ml.In the control group,the levels of IL-1, IL-6, and TNF-α were (26.37±3.18), (185.52±20.31), and (108.69±8.49) ng/ml, respectively.The levels of IL-1, IL-6 and TNF-α in observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The clinical effect of Moxifloxacin combined with Mycobacterium vaccae in the treatment of patients with multidrug-resistant pulmonary tuberculosis is remarkable, which can reduce the level of inflammatory mediators and increase the negative conversion rate of sputum and bacterium.
2020 Vol. 27 (3): 58-60 [Abstract] ( 105 ) HTML (40 KB)  PDF  (0 KB)  ( 14 )
61 Application value of serum C-reactive protein and procalcitonin in the diagnosis and treatment of acute pancreatitis
ZHANG Jun-bo
Objective To investigate the application value of serum C-reactive protein (CRP) and procalcitonin (PCT)in the diagnosis and treatment of acute pancreatitis.Methods A total of 98 patients with acute pancreatitis treated in our hospital from February 2017 to February 2019 were selected as the acute pancreatitis group.According to the patients′ condition, they were divided into mild acute pancreatitis group (30 cases) and severe acute pancreatitis group(68 cases).Another 60 healthy volunteers were selected as the control group.The serum PCT and CRP levels in patients with acute pancreatitis and the control group were measured, and the the PCT and CRP levels of patients with acute pancreatitis on the first and seventh day after admission were monitored, and the value of PCT, CRP alone and in combination in the diagnosis of acute pancreatitis were analyzed.Results The serum levels of PCT and CRP in the acute pancreatitis group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The levels of serum PCT and CRP in severe acute pancreatitis group were higher than those in mild acute pancreatitis group on the first and seventh day after admission, the differences were statistically significant (P＜0.05).ROC curve analysis showed that the sensitivity of serum CRP and PCT levels single and combined diagnosis of acute pancreatitis was 69.39%, 78.57%, and 97.96%, respectively, and the specificity was 74.49%, 80.61%, and 85.71%, respectively.Conclusion The detection of serum CRP and PCT plays an important role in the early diagnosis, treatment,severity grading and evaluation of the development of acute pancreatitis, combined detection has certain diagnostic efficacy, which can provide reference for clinical diagnosis and treatment.
2020 Vol. 27 (3): 61-64 [Abstract] ( 90 ) HTML (34 KB)  PDF  (0 KB)  ( 14 )
65 Clinical effect of Probiotics pretreatment combined with quadruple therapy in the treatment of failed Helicobacter pylori infection
ZHAN Yun-kai； YI Jing ； DUAN Zhi-gang
Objective To explore the curative effect of pretreatment with Probiotics combined with quadruple therapy in the remedial treatment of infection of Helicobacter pylori (Hp).Methods From June 2016 to June 2018, 104 patients with Hp positive initial failure in our hospital were selected and divided into experimental group (n=52) and control group (n=52) number according to the patient′s medical treatment sequence.The patients in the control group were treated with routine quadruple therapy (Rabeprazole+Amoxicillin+Clavulacillin Citrate+Potassium Bismuth Citrate),while the patients in the experimental group were treated with Bifidobacterium Tetracycline Tablets for two weeks and then the patients in the experimental group were treated with routine quadruple therapy.Two groups of patients were treated for 2 weeks, and eradication effect and adverse reactions of Hp eradication between the two groups were compared.The tolerance of the two groups was counted.Results The effective rates of eradication of Hp in the experimental group and the control group were 84.62% and 78.85%, respectively, there was no significant difference between the two groups (P＞0.05).The incidence of adverse reactions in the experimental group was 1.92%, which was lower than that of the control group (17.31%), the difference was statistically significant (P<0.05).The grade distribution of tolerance in the experimental group was lower than that in the control group, and the difference was statistically significant(P<0.05).Conclusion After the failure of the first treatment, the Hp infection was treated with Bifidobacterium Quadruple Live Bacteria Tablets for two weeks and then treated with conventional quadruple therapy for remedial treatment, although the eradication rate of Hp could not be improved exactly, it is helpful to reduce the adverse reactions and improve the tolerance of patients, which has certain clinical application value.
2020 Vol. 27 (3): 65-67 [Abstract] ( 120 ) HTML (32 KB)  PDF  (0 KB)  ( 17 )
68 Clinical effect of procalcitoninin guiding antibiotics in patients with severe infection
XIE Min-chong
Objective To investigate the clinical effect of procalcitonin (PCT) in guiding antibiotics in patients with severe infection.Methods A total of 100 patients with severe infections from May 2017 to February 2019 treated in our hospital were selected.According to the random number table method, patients were divided into conventional treatment group and PCT guide group, 50 cases in each group.The conventional treatment was treated with conventional antibiotics treatment, and the PCT guide group was treated with PCT to guide the treatment of antibiotics.The total effective rate of the two groups was compared; the time of infection control, the average time of antibiotic use, the total length of hospital stay, the level of C-reactive protein monitoring before and after treatment, and the white blood cell count, PCT and the incidence of multi-drug resistant infection of the two groups was compared.Results The total effective rate of the PCT guide group was higher than that of the conventional treatment group, and the difference was statistically significant (P<0.05).The time to control the infection, the antibiotic use time, and the total hospital stay of the PCT guide group were shorter than those of the conventional treatment group, the differences were statistically significant (P<0.05).The level of C-reactive protein in the PCT guide group and the white blood cell count，PCT were lower than those in the conventional treatment group, and the differences were statistically significant (P<0.05).The rate of multidrug-resistant infection in the PCT guide group was 2% (1/50), which was lower than that in the conventional treatment group for 18% (9/50), and the difference was statistically significant (P<0.05).Conclusion PCT can guide the treatment of severe infections,it can achieve the desired effect, can effectively shorten the time of antibiotic use, and reduce the incidence of multi-drug resistant infection.
2020 Vol. 27 (3): 68-70 [Abstract] ( 116 ) HTML (30 KB)  PDF  (0 KB)  ( 7 )
71 Effect of laparoscopic total extraperitoneal inguinal hernia prosthetic in the treatment of inguinal hernia
ZHONG Dong-jia; YUAN Yang-chun; LUO Yu-qing; LIN Gui-hai; WU Hai-feng
Objective To compare the effect of laparoscopic total extraperitoneal prosthetic(TEP) and open tension-free repair of inguinal hernia in the treatment of inguinal hernia.Methods From January 2016 to December 2018, 87 patients with inguinal hernia treated in our hospital were selected and divided into study group (46 cases) and control group (41 cases) according to random number table method.Open tension-free repair of inguinal hernia was performed in the control group and laparoscopic TEP was performed in the study group.The related indexes and postoperative complications of the two groups were compared.Results The operation time of the patients in the study group was(68.40±8.05) min, hospital stay was (4.20±0.75) d; and the time of getting out of bed was (14.35±4.10) h, which was shorter than that of the control group for (98.50±5.85) min, (6.55±0.50) d, (18.35±4.50) h, the differences were statistically significant (P<0.05).The intraoperative blood loss in the study group was (3.21±0.88) ml, which was lower than that in the control group (4.85±0.95) ml, the difference was statistically significant (P<0.05).The incidence of postoperative complications in the study group was 4.35%, which was lower than that in the control group (14.63%), the difference was statistically significant (P<0.05).Conclusion The effect of laparoscopic TEP in the treatment of inguinal hernia is better than that of tension-free repair of inguinal hernia through preperitoneal space, and is more beneficial to postoperative rehabilitation.
2020 Vol. 27 (3): 71-73 [Abstract] ( 72 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
74 Clinical effect of Compound Methoxyphenamine combined with Montelukast Sodium in the treatment of cough variant asthma
LIU Zhi-biao; WANG Lin-yue; YAN Jie-hua
Objective To investigate the clinical effect of Compound Methoxymine combined with Montelukast Sodium in the treatment of cough variant asthma (CVA).Methods From April 2017 to April 2018, 68 patients with CVA treated in our hospital were selected as research objects.According to the random digital table method, they were divided into the control group and the study group, 34 cases in each group.The patients in both groups received routine symptomatic treatment.On this basis, the control group was treated with Compound Methoxanamine oral treatment, and the study group was treated with Compound Methoxymine combined with Montelukast Sodium.The clinical efficacy, cough score before and after treatment and adverse reactions (including gastrointestinal adverse reactions, dyspepsia, nausea and vomiting, diarrhea) were compared between the two groups.Results The total effective rate of clinical treatment in the study group was 97.06%, which was higher than that in the control group (82.35%), the difference was statistically significant (P<0.05).The daytime cough score and nocturnal cough score in the study group were (2.02±0.40) and(2.03±0.45) points, respectively, which were not significantly different from those in the control group for (2.05±0.37)and (2.06±0.42) points before treatment (P＞0.05).After treatment, the daytime cough score and nocturnal cough score in the study group were (1.01±0.05) and (1.03±0.04) points, respectively, which were lower than those in the control group for (1.35±0.25) and (1.31±0.30) points respectively, the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the study group was 2.94%, lower than 20.59% of the control group, the difference was statistically significant (P<0.05).Conclusion Clinical effect of Compound Methoxymine combined with Montelukast Sodium in the treatment of CVA is remarkable.
2020 Vol. 27 (3): 74-76 [Abstract] ( 133 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
77 Effect of bronchoscopic alveolar lavage in the treatment of obstructive atelectasis
HE Shu-ping
Objective To investigate the effect of bronchoscopy alveolar lavage in the treatment of obstructive atelectasis.Methods A total of 98 patients with obstructive atelectasis who were treated in our hospital from March 2017 to March 2019 were selected and divided into the study group and the control group according to random number table method, 49 cases in each group.The control group was treated with traditional treatment mode.The study group was treated with bronchial alveolar lavage on the basis of the control group.The clinical treatment effect and the total incidence of complications were compared between the two groups.Results The total effective rate of treatment in the study group was 95.9%, higher than that in the control group (81.6%), and the difference was statistically significant(P<0.05).The total incidence of complications in the study group was 6.1%, which was lower than that in the control group (24.5%), the difference was statistically significant (P<0.05).Conclusion In the treatment of patients with obstructive atelectasis, the use of bronchoscopy alveolar lavage measure can improve the clinical treatment of patients,further reduce the overall incidence of disease complications, the treatment has a certain degree of safety, which help patients recover and is worthy of clinical promotion.
2020 Vol. 27 (3): 77-79 [Abstract] ( 74 ) HTML (28 KB)  PDF  (0 KB)  ( 13 )
80 Effect of Omeprazole and Octreotide combined with Kangfuxin Solution in the treatment of acute upper gastrointestinal bleeding
ZHANG Zhang; CAO Huo-liu; XU Qiu-xia; CHEN Xin-dai
Objective To study the effect of Omeprazole and Octreotide combined with Kangfuxin Solution in the treatment of acute upper gastrointestinal bleeding.Methods A total of 100 cases of acute upper gastrointestinal bleeding treated in our hospital from July 2016 to June 2018 were selected as the study objects.They were divided into study group and control group by random number table method, 50 cases in each group.Patients in the study group were treated with Omeprazole and Octreotide combined with Kangfuxin Solution, while patients in the control group were treated with Omeprazole alone.The hemostasis time, hospitalization time, rebleeding rate, total success rate of hemostasis, total incidence of adverse reactions and total effective rate of treatment were evaluated.Results The hemostasis time ([19.52±5.73]h) and hospitalization time ([7.12±1.36]d) in the study group were both shorter than those in the control group ([46.05±6.38]h, [13.17±1.62]d), with statistically significant differences (P＜0.05).The total effective rate(98.00%) and the total success rate of hemostasis (100.00%) in the study group were higher than those in the control group (86.00%, 90.00%), with statistically significant differences (P＜0.05).The total incidence of adverse reactions (6.00%) and the rebleeding rate (4.00%) in the study group were lower than those in the control group(20.00%, 18.00%), with statistically significant differences (P＜0.05).Conclusion Omeprazole and Octreotide combined with Kangfuxin Solution can effectively hemostasis, shorten hospitalization time, avoid adverse reactions such as nausea and vomiting, and reduce the rate of rebleeding in patients with acute upper digestive hemorrhage.It is safe to improve the success rate of hemostasis, improve the prognosis of patients and improve the quality of life.It is worthy of clinical application.
2020 Vol. 27 (3): 80-83 [Abstract] ( 99 ) HTML (40 KB)  PDF  (0 KB)  ( 10 )
84 Clinical effect of Irbesartan combined with Xinkeshu in the treatment of patients with abdominal obesity complicated with essential hypertension and hyperlipidemia
LIU Juan-feng; WANG Li-jun; WANG Ping
Objective To observe the clinical effect of Irbesartan combined with Xinkeshu in the treatment of patients with abdominal obesity complicated with essential hypertension and hyperlipidemia.Methods One hundred patients with abdominal obesity complicated with essential hypertension and hyperlipidemia who were treated in our hospital from June 2017 to September 2018 were selected as subjects.According to the different treatment methods, they were divided into experimental group and control group, each group with 50 cases.Patients in the experimental group were treated with Irbesartan combined with Xinkeshu, while patients in the control group were treated with Irbesartan alone.The therapeutic effect, blood pressure and blood lipid before and after treatment were compared between the two groups.Results The total effective rate in the control group was 90.0%, and the total effective rate in the experimental group was 92.0%.There was no significant difference in the total effective rate between the two groups (P＞0.05).After treatment, the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups were lower than before, and the differences were statistically significant (P＜0.05).There were no significant differences in SBP and DBP between the two groups after treatment (P＞0.05).After treatment, the triglyceride (TG), total cholesterol (TC) and lowdensity lipoprotein cholesterol (LDL-C) in the two groups were all lower than before treatment, with statistically significant differences (P＜0.05).The TG, TC and LDL-C in the experimental group were lower than those in the control group after treatment, with statistically significant differences (P＜0.05).Conclusion Xinkeshu could not effectively reduce the blood pressure of patients in terms of treatment, but compared with Irbesartan alone, Xinkeshu could improve the blood lipid level in patients.The combined use of Xinkeshu and Irbesartan in the treatment of patients with abdominal obesity complicated with essential hypertension and hyperlipidemia, can achieve a better effect, which is worthy of being popularized and applied in clinical treatment.
2020 Vol. 27 (3): 84-87 [Abstract] ( 127 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
88 Application value of Dexmedetomidine in the treatment of intensive care unit delirium
SONG Jia-cai; CAI Long ; TANG Yi
Objective To explore the value of Dexmedetomidine in the treatment of sputum in intensive care unit(ICU).Methods Fifty patients with ICU delirium who were admitted to our hospital from June 2016 to July 2017 were selected as study subjects.They were assigned to the observation group and the control group according to the random number table method, with 25 cases in each group.The observation group was treated with Dexmedetomidine, and the control group was given intravenous Haloperidol.The ICU treatment time, total hospital stay, ideal sedation time, Richmond agitation-sedation scale (RASS) score, and clinical adverse reactions were compared between the two groups.Results The ICU treatment time and total hospitalization time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).The ideal sedation time of the observation group was shorter than that of the control group, and RASS score of the observation group was lower than that of the control group, and the differences were statistically significant (P＜0.05).There were no serious side effects in either group.The incidence of hypotension, bradycardia or sinus arrest were lower in the observation group than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion Dexmedetomidine in the treatment of patients with ICU can reduce the occurrence of sputum and cure ICU patients as soon as possible, which can shorten the hospitalization time of ICU sputum patients and reduce medical expenses, and has high clinical value.
2020 Vol. 27 (3): 88-90 [Abstract] ( 85 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
91 Effect of Sharkurba Trivalsartan Sodium in the treatment of chronic heart failure
LI Wen-bo
Objective To investigate the effect of Sharkurba Trivalsartan Sodium in the treatment of chronic heart failure.Methods A total of 180 cases of patients with chronic heart failure who received treatment in our hospital from January 2017 to January 2019 were selected as subjects, they were divided into control group and study group according to the random number table method, with 90 cases in each group.The control group was treated with Valsartan Capsules, and the study group was treated with Shakurba Triv alsartan Sodium.The clinical effect, the changes of plasma N-terminal frontal brain natriuretic peptide (NT-pro BNP) and exercise tolerance levels were compared between the two groups.Results The total effective rate in the study group was higher than that in the control group, the difference was statistically significant (P＜0.05).After treatment, the plasma NT-pro BNP level in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05).After treatment, the plasma NT-pro BNP level of the two groups was lower than that before treatment, the difference was statistically significant (P＜0.05).After treatment, the 6 min walking distance of the study group was longer than that of the control group, and the blood oxygen saturation (SpO2) level was higher than that of the control group, with statistically significant differences (P＜0.05).After treatment, the 6 min walking distance of both groups was longer than that before treatment, and the SpO2 level was higher than that before treatment, with statistically significant differences (P＜0.05).Conclusion The use of Shakurba Travalsartan Sodium in the treatment of chronic heart failure patients not only has a high clinical efficacy,but also can effectively improve the exercise tolerance of patients and reduce the level of plasma NT-pro BNP , which is worthy of widely use in clinical.
2020 Vol. 27 (3): 91-93 [Abstract] ( 77 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
94 Application effect of Dacronin Hydrochloride Mucilage in colonoscopy
HU Jun; FAN Yan-jun; LI Zhi-jin; HUANG Xiao-mei
Objective To observe the application effect of oral different doses of Dacronin Hydrochloride Mucilage in colonoscopy.Methods From July 1 to December 31, 2018, 843 patients who underwent colonoscopy in the digestive department of our hospital were randomly divided into high dose group (288 cases), low dose group (281 cases) and control group (274 cases).All the patients in each group were prepared with Polyethylene Glycol before operation.A total of 40 ml and 100 ml warm water were given to the high dose group 1 hour before enteroscopy, and 20 ml and 100 ml warm water were given to the low dose group.The control group did not take Dacronin Hydrochloride Mucilage, did not take any measures.The colonoscopy was performed by the same senior endoscopic surgeon to evaluate the grade of intestinal foam and the score of intestinal cleanliness, and the colonoscopy time, operation time and polyp detection rate of the three groups were recorded and compared.Results The foam quantity grade of the high dose group and the low dose group were better than that of the control group, and the differences were statistically significant (P＜0.05).The grade of intestinal foam volume in the high-dose group was better than that in the low-dose group, and the difference was statistically significant (P＜0.05).The Boston bowel preparation scale (BBPS) scores of the high dose group, the low dose group and the control group were (7.84±0.97), (7.96±1.04) and (7.88±1.09) points, respectively.There were no significant differences in BBPS scores among the three groups (P ＞0.05).There was no significant difference in colonoscopy time in the three groups (P＞0.05).The colonoscopy time of the high dose group and the low dose group was shorter than that of the control group, and the differences were statistically significant (P＜0.05).The colonoscopy time of the high dose group was shorter than that of the low dose group, and the difference was statistically significant(P＜0.05).The detection rate of total polyps and micropolyps in the high dose group was not significantly different from that in the low dose group (P＞0.05).No serious adverse reactions such as dizziness, headache, chest tightness, palpitations and drug allergy occurred in the high dose group and the low dose group.Among all the patients, 11 patients experienced nausea, vomiting, abdominal distension and other discomfort during intestinal preparation, including 3 patients in the high dose group, 5 patients in the low dose group and 3 patients in the control group, which were considered to be related to the preparation of taking a large amount of water into the intestinal tract in a short period of time, but not related to the oral administration of dacronin hydrochloride pulp and glue.Conclusion Dacronin Hydrochloride Mucilage can effectively remove intestinal foam and improve the detection rate of intestinal polyps and micropolyps, and the effect of oral 40 ml Dacronin Hydrochloride Mucilage in removing intestinal foam is better than that of 20 ml.
2020 Vol. 27 (3): 94-97 [Abstract] ( 80 ) HTML (41 KB)  PDF  (0 KB)  ( 12 )
98 Therapeutic effect of painless colonoscopy combined with Compound Polyethylene Glycol Electrolyte Powder in elderly colon polyps
NIU Chao
Objective To investigate the therapeutic effect of painless colonoscopy combined with Compound Polyethylene Glycol Electrolyte Powder in elderly colon polyps.Methods A total of 78 elderly patients with colon polyps admitted to our hospital from October 2016 to March 2019 were selected as the study subjects, and were randomly divided into reference group (39 cases) and study group (39 cases) by odd even number lottery method.Patients in the control group were treated with Magnesium Sulfate by painless colonoscopy, and patients in the study group were treated with Compound Polyethylene Glycol Electrolyte Powder by painless colonoscopy.The indexes related to surgery, polypectomy rate, total postoperative complication rate and quality of life score of the two groups were compared.Results The operation time and hospital stay of the study group were shorter than those of the reference group, and the differences were statistically significant (P＜0.05).The polypectomy rate in the study group was higher than that in the reference group, and the difference was statistically significant (P＜0.05).The total incidence of complications in the study group was lower than that in the reference group, and the difference was statistically significant (P＜0.05).The postoperative quality of life score in the study group was higher than that in the reference group, and the difference was statistically significant (P＜0.05).Conclusion Compared with oral Magnesium Sulfate, the application of Compound Polyethylene Glycol Electrolyte Powder can not only effectively remove intestinal contents during the intestinal cleansing stage before surgery in elderly patients with colon polyps using painless colonoscopy.On the basis of improving the operation efficiency and polypectomy rate, and can further reduce the incidence of postoperative complications, optimize the quality of postoperative life, and promote its early recovery to health, it is worthy of clinical reference and promotion.
2020 Vol. 27 (3): 98-100 [Abstract] ( 81 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
101 Clinical effect comparison of Levofloxacin and Moxifloxacin in the treatment of multidrug-resistant pulmonary tuberculosis
DANG Pei-ying
Objective To explore the clinical effect of Levofloxacin and Moxifloxacin in the treatment of multidrug-resistant pulmonary tuberculosis.Methods A total of 160 patients with multi-drug resistant pulmonary tuberculosis treated in our hospital from January to September 2016 were selected as research subjects, and they were divided into control group and experimental group according to the random number table method, with 80 cases in each group.The control group was mainly treated with Levofloxacin combined with Capreomycin, while the experimental group was mainly treated with Moxifloxacin combined with Capreomycin.The therapeutic effect, lesion absorption and sputum bacteria changes of the two groups were observed and compared.Results The total effective rate of treatment in the experimental group was 86.25%, which was higher than that in the control group accounting for 61.25%, and the difference was statistically significant (P＜0.05).The total absorption rate of lesions in the experimental group was 92.50%,which was higher than that in the control group accounting for 78.75%, and the difference was statistically significant(P＜0.05).The smear negative rate and sputum tuberculosis negative rate of the experimental group at 24 months of treatment were 83.75% and 86.25% respectively, which were significantly higher than those of the control group accounting for 57.50% and 58.75%, and the differences were statistically significant (P＜0.05).Conclusion Moxifloxacin combined with Capreomycin is effective in the treatment of multi-drug resistant pulmonary tuberculosis, which can promote lesion absorption and increase sputum negative rate.It is worthy of popularization and application.
2020 Vol. 27 (3): 101-103转107 [Abstract] ( 85 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
104 Effect of different dialysis vascular pathways on left ventricular hypertrophy and function in elderly patients with maintenance hemodialysis
LIU Min
Objective To investigate the effects of different dialysis pathways on left ventricular hypertrophy and function in elderly patients with maintenance hemodialysis.Methods A total of 60 elderly patients with maintenance hemodialysis admitted to our hospital from January 2016 to January 2018 were selected as the study objects, they were divided into control group and study group according to the random number table method, with 30 cases in each group.The control group received the indwelling method of deep venous catheter, and the study group received the indwelling method of arteriovenous fistula.The cardiac structure-related indexes before and after the establishment of the two groups were compared, the cardiac function indexes and the occurrence of adverse reactions 1 year after the establishment of the two groups were compared.Results After the establishment of the pathway, the left ventricular end diastolic diameter ([52.60±4.55]mm), the inter-ventricular septum end-diastolic thickness ([12.15±1.25]mm), and the left ventricular posterior wall end-diastolic thickness ([11.50±1.65]mm) in the study group, which were higher than those of the control group ([49.80±5.30], [11.05±2.65], and [10.45±2.05]mm), the differences were statistically significant (P＜0.05).After the establishment of the pathway, there were no statistically significant differences in the ventricular ejection fraction, the maximum velocity ratio of left atrial valve orifice in early and late diastolic period between the two groups (P＞0.05).After the establishment of the pathway, the incidence of left ventricular hypertrophy in the study group was 60.00%, the incidence of left ventricular systolic dysfunction was 16.67%, the incidence of left ventricular diastolic dysfunction was 53.33%, and the total incidence of adverse reactions was 3.33%, all of which were lower than 83.33%,43.33%, 80.00%, and 20.00% in the control group, with statistically significant differences (P＜0.05).Conclusion Compared with deep venous catheter indwelling, arteriovenous fistula indwelling has lower effect on left ventricular hypertrophy and function in elderly maintenance hemodialysis patients, and the incidence of adverse reactions is low, so it has important clinical application value.
2020 Vol. 27 (3): 104-107 [Abstract] ( 77 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
108 Characteristics of magnetic resonance proton spectroscopy in non-demented patients with vascular cognitive impairment
MAO Li-wei； XU Qiang-hua； MA Li-na； CHEN Xia； WANG Wei； JIANG Wen-ting； WANG Jian-lin
Objective To explore the characteristics of magnetic resonance proton spectroscopy (1H-MRS) in non-demented patients with vascular cognitive impairment.Methods A total of 100 stroke patients admitted in our hospital from July 2015 to July 2017 were selected as research objects, they were divided into poststroke cognitive impairment no dementia (PS-CIND) group and post-stroke cognitive function group (NC) according to the presence of cognitive impairment after stroke, 50 cases in each group.The cognitive function scores of the two groups were compared;1H-MRS was performed in the two groups, and the hippocampal N-acetylaspartate/creatine (NAA/Cr) and choline complex (Cho)/Cr values were compared.Results The scores of prospective memory (EBPM), stroop color word test (SCWT),digital connection test (TMT), symbol coding test (DSCT), and digital span test (DST) in the PS-CIND group were higher than those in the NC group, the differences were statistically significant (P＜0.05).The simple mental state scale(MMSE) score and NAA/Cr values of the PS-CIND group were lower than those of the NC group, the differences were statistically significant (P＜0.05).There was no significant difference in Cho/Cr values between the two groups (P＞0.05).Conclusion NAA/Cr is significantly reduced in patients with non-dementia-type cognitive impairment after stroke,which can be used as a basis for early diagnosis of PS-CIND.
2020 Vol. 27 (3): 108-110 [Abstract] ( 85 ) HTML (34 KB)  PDF  (0 KB)  ( 13 )
111 Application effect of case management in community schizophrenia patients
XU Xiu-ying; ZENG Li; WANG Li-mei; LIN Mei-rong; CHEN Miao-ru; WANG Wen-qiang
Objective To explore the application effect of case management in community schizophrenia patients.Methods Eighty patients with community schizophrenia who were registered in a district of Xiamen from June to October 2017 were selected as study subjects, they were divided into case management group (40 cases) and routine management group (40 cases) according to the random number table method.The routine management group gave routine community follow-up, and the case management group implemented case management for one year on this basis.The scores of the concise psychiatric scale (BPRS), the social function defect screening scale (SDSS), and the health checklist (SF-36) before and after the intervention were compared between the two groups.Results The BPRS and SDSS scores of the case management group after the intervention were lower than those of the pre-intervention and conventional management groups, the physical function (PF), vitality (VT), social function (SF), mental health (MH), and overall health (GH) scores in SF-36 were higher than those before the intervention and the conventional management group,the differences were statistically significant (P<0.05).Conclusion Individual case management for schizophrenia in the community is conducive to improving mental symptoms, social dysfunction and quality of life.
2020 Vol. 27 (3): 111-114 [Abstract] ( 75 ) HTML (39 KB)  PDF  (0 KB)  ( 13 )
115 Applicatin effect of bibliotherapy on long-term hospitalized schizophrenics
GUAN Kun-lian； LI Gui-yun； ZHOU Hai-ping； OUYANG Xiao-fen； LIU Fu-rong
Objective To explore the application effect of bibliotherapy on long-term hospitalized schizophrenics.Methods A total of 120 cases of long-term hospitalized schizophrenics treated in our hospital from January 2017 to December 2018 were selected as the subjects, and divided into reading treatment group and the conventional treatment group by random number table method, with 60 cases in each group.Patients in the conventional treatment group were given conventional drug treatment, while patients in the reading treatment group were given the specified prescription according to the bibliotherapy on basis of conventional drug treatment.The brief psychiatric rating scale (BPRS) was used to evaluate the effect of the two groups of patients before treatment and after2, 4, 6, 8 weeks of treatment.Results The total scores of BPRS in the reading treatment group were lower than those in the conventional treatment group after 4, 6, 8 weeks of treatment, the differences were statistically significant (P＜0.05).The scores of anxiety and depression,lack of vitality and thinking disorder in the reading treatment group after 8 weeks of treatment were lower than those before treatment and the conventional treatment group, the differences were statistically significant (P＜0.05).There were no significant difference in the scores of irritability and hostility suspicion between the two groups after 8 weeks of treatment (P ＞0.05).Conclusion Bibliotherapy was an effective treatment for the pa tients with long-term hospitalized schizophrenics.It can reduce the score of BPRS, which is worthy of clinical application.
2020 Vol. 27 (3): 115-117转121 [Abstract] ( 85 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
118 Effect of microsurgery in the treatment of cerebral arteriovenous malformation hemorrhage
LIANG Wei； CAI Wen-li； WANG Dong-ting ； ZHANG Xue-jun； GAO Yin-liang
Objective To discuss the effect of microsurgery in the treatment of cerebral arteriovenous malformation(AVM) hemorrhage.Methods The clinical data of 80 patients with cerebral AVM hemorrhage who were admitted to the hospital from October 2013 to October 2018 were retrospectively analyzed.They were divided into observation group(n=40) and control group (n=40) according to different treatment methods.The observation group was given microsurgery, while control group was treated by endovascular embolization.The clearance of vascular mass, incidence of postoperative complications and prognosis were compared between the two groups.Results The cure rate of observation group was higher than that of control group (97.50% vs.75.00%) (P＜0.05).There was no significant difference in incidence of complications between the two groups (P＞0.05).The good prognosis rate of observation group was higher than that of control group (92.50% vs.72.50%) (P＜0.05).Conclusion Microsurgery is a safe and effective method for treatment of cerebral AVM hemorrhage.The appropriate microsurgery method should be selected according to the condition clinically.
2020 Vol. 27 (3): 118-121 [Abstract] ( 80 ) HTML (34 KB)  PDF  (0 KB)  ( 13 )
122 Application effect comparison the first hepatic portal blood flow occlusion method and hemi-hepatic blood flow occlusion method in the treatment of primary hepatocellular carcinoma patients with hemi-hepatectomy
ZENG San-ping
Objective To analyze the application effect of the first hepatic portal blood flow occlusion method and hemi-hepatic blood flow occlusion method in the treatment of primary hepatocellular carcinoma (HCC) patients with hemi-hepatectomy.Methods A total of 80 cases of HCC patients with hemi-hepatectomy who were treated in our hospital from October 2010 to October 2018 were selected as subjects.They were divided into study group and control group by random number table method, 40 cases in each group.The control group was treated with the first hepatic portal blood flow occlusion method, the study group was treated with the hemi-hepatic blood flow occlusion method.The recent complications, blood flow interruption time, intraoperative blood loss, postoperative hospital stay and improvement of liver function in the two groups were compared.Results There was no significant difference between the two groups in postoperative blood flow interruption time and postoperative hospital stay (P＞0.05).The intraoperative blood loss in the study group was less than that in the control group, and the difference was statistically significant (P＜0.05).There were no significant difference in the levels of serum alanine aminotransferase (ALT), total bilirubin (TBil) and aspartate aminotransferase (AST) before surgery between the two groups (P＞0.05).After surgery, the levels of ALT, AST and TBil in both groups were lower than before surgery, and the levels of ALT, AST and TBil in the study group were lower than those in the control group, with statistically significant differences (P＜0.05).The total incidence of postoperative complications in the study group was lower than that in the control group, and the difference was statistically significant(P＜0.05).Conclusion For HCC patients with hemi-hepatectomy, the half-hepatic blood flow occlusion method is superior to the first hepatic portal blood flow occlusion method in protecting liver function, and it can greatly reduce the incidence of complications after operation, the curative effect is safer and more reliable.
2020 Vol. 27 (3): 122-124 [Abstract] ( 74 ) HTML (34 KB)  PDF  (0 KB)  ( 16 )
125 Clinical effect of Decitabine combined with CHG regimen in the treatment of medium or high risk elderly acute myeloid leukemia
YAN Chao-qi; LENG Qing; JI Zheng; WU Yin; ZHANG Li-jun
Objective To investigate the clinical effect of Decitabine combined with CHG regimen in the treatment of medium or high risk elderly acute myeloid leukemia (AML).Methods From June 2016 to June 2019, 60 elderly patients with acute moderate to high risk AML admitted to Central Hospital of Anshan city were included as the research objects, and divided into Decitabine combined CHG regimen treatment group (32 cases) and monotherapy group (28 cases) according to the random number table method.The Decitabine combined with CHG regimen treatment group was treated with Decitabine 20 mg/(m2·d) combined with CHG regimen chemotherapy, while the monotherapy group was only treated with Decitabine single drug, and the dosage was the same as that of the Decitabine combined with CHG regimen treatment group.The clinical effects, blood picture recovery time and adverse reactions of the two groups after one course of treatment were compared.Results There was no significant difference in the total effective rate between the two groups(P＞0.05).There were no significant difference in recovery time of platelets and leukocytes between the two groups(P＞0.05).The incidence of infection in patients of the Decitabine combined with CHG regimen treatment group was higher than that in patients of the monotherapy group,the difference was statistically significant(P＜0.05),while there were no statistically significant difference in liver function damage, nausea, vomiting, constipation, fatigue incidence and mortality between the two groups (P＞0.05).Conclusion After completing one course of treatment, the total effective rate of Decitabine combined with CHG regimen treatment group did not improve, but the incidence of infection may be greater.
2020 Vol. 27 (3): 125-128 [Abstract] ( 88 ) HTML (37 KB)  PDF  (0 KB)  ( 12 )
129 Effect of paravertebral block combined with general anesthesia on postoperative stress response in patients with colorectal cancer resection
DU Xue-jun
Objective To investigate the effect of paravertebral block combined with general anesthesia on postoperative stress response in patients with colorectal cancer resection.Methods A total of 200 patients with colorectal cancer resection admitted to our hospital from May 2016 to May 2018 were selected as the research objects.According to the method of drawing lots, they were divided into observation group (100 cases) and control group (100 cases).The observation group was given paravertebral block combined with general anesthesia, while the control group was given general anesthesia.The hospitalization stay, extubation time, visual analogue scale (VAS) score and the levels of cortisol (Cor),angiotensin Ⅱ(Ang Ⅱ), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were compared between the two groups.Results The hospitalization stay ([10.12±0.11]d) and extubation time ([5.01±3.01]h) in the observation group were shorter than those in the control group ([12.21±3.15]d, [7.23±3.45]h), and the differences were statistically significant (P<0.05).The levels of Cor ([241.52±43.25]pg/ml), AngⅡ ([70.23±6.27]pg/ml) in the observation group were lower than those in the control group ([275.21±52.11], [86.45±10.11]pg/ml), and the differences were statistically significant (P<0.05).The VAS score of the observation group was (2.01±0.45) points, which was lower than that of the control group for (4.25±0.76) points, and the difference was statistically significant (P<0.05).The levels of CRP([37.15±9.21]mg/L) and TNF-α ([53.01±15.23]pg/ml) in the observation group were lower than those in the control group ([43.11±10.25]mg/L, [62.11±16.45]pg/ml), and the differences were statistically significant (P<0.05).Conclusion Paravertebral block combined with general anesthesia can improve the stress response and reduce pain in patients undergoing colorectal cancer resection.
2020 Vol. 27 (3): 129-131 [Abstract] ( 66 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
132 Application effect of Propofol combined with Remifentanil in pediatric anesthesia to maintain laryngeal mask ventilation
CHEN Yan; GU You-lan; DAI Zai-shen; CAO Hua-na
Objective To investigate the application effect of Propofol combined with Remifentanil in pediatric anesthesia to maintain laryngeal mask ventilation.Methods A total of 59 children with surgery treated in our hospital from October 2018 to March 2019 were selected as the subjects, and divided into observation group (n=29) and control group(n=30) by random number table method.The observation group received anesthesia with Propofol combined with Remifentanil, and the control group received anesthesia with Dexmedetomidine combined with Remifentanil.The heart rate (HR), blood oxygen saturation (SpO2) during the operation, wake-up of the child after the operation and adverse reactions were compared between the two groups.Results The HR in the observation group after anesthesia induction,laryngeal mask insertion, operation completion and laryngeal mask removal were lower than those in the control group,and the SpO2 were higher than those in the control group, the differences were statistically significant (P＜0.05).The Ramsay sedation score of children in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion In pediatric surgery with laryngeal mask ventilation, the overall effect of using Propofol combined with Remifentanil is better than that of Dexmedetomidine combined with Remifentanil, the safety is higher, and it is worthy of clinical application.
2020 Vol. 27 (3): 132-134 [Abstract] ( 75 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
135 Comparison the anesthesia effect of Ropivacaine unilateral spinal anesthesia with different specific gravity in lower limb surgery anesthesia
SONG Qiang
Objective To compare the anesthetic effect of Ropivacaine unilateral spinal anesthesia with different specific gravity in lower limb surgery anesthesia.Methods A total of 60 patients with unilateral spinal anesthesia in our hospital from January 2017 to March 2019 were selected as the study objects, they were divided into group A (30 cases) and group B (30 cases) according to the random number table method.Group A received 11.25 mg Ropivacaine(0.75%) and 2 ml sterile water for injection, group B received 11.25 mg Ropivacaine (0.75%) and 2 ml 10% glucose.The time of onset of sensory block, duration of sensory block, duration of motor block, duration of motor block, vital signs, anesthesia effect, recovery time of micturition and lower extremity movement and adverse reactions were compared between the two groups.Results There were no significant differences in the onset time, duration of sensory block, onset time of motor block and duration of motor block between the two groups (P＞0.05).There were no significant differences in systolic blood pressure, diastolic blood pressure and heart rate between the two groups (P＞0.05).There was no significant difference in anesthesia excellen and good rate between the two groups (P＞0.05).The recovery time of micturition and lower extremity movement in group A were shorter than those in group B, the differences were statistically significant (P＜0.05).There were no significant differences in the incidence of nausea, vomiting, shivering and headache between the two groups (P＞0.05).Conclusion The anesthesia effect of light specific gravity ropivacaine in the operation of lower limbs is similar to that of heavy specific gravity ropivacaine, but light specific gravity ropivacaine can shorten the recovery time of urination and movement of lower limbs, and does not increase the adverse reactions of patients, so it can be used according to the patients' clinical conditions.
2020 Vol. 27 (3): 135-137转141 [Abstract] ( 67 ) HTML (34 KB)  PDF  (0 KB)  ( 17 )
138 Application effect of Dexmedetomidine on elderly patients with mild depression after combined spinal and epidural anesthesia
TIAN Liang； LI Chao-yang； ZHANG Jie▲
Objective To investigate the application effect of Dexmedetomidine on elderly patients with mild depression after combined spinal and epidural anesthesia.Methods A total of 80 elderly patients with mild depression who received combined spinal and epidural anesthesia for lower extremity orthopaedic surgery in our hospital from May 2018 to April 2019 were selected as the study objects, they were divided into control group and experimental group according to the random number table method, 40 cases in each group.The control group was intravenously sedated by Midazolam, and the experimental group was intravenously sedated by Dexmedetomidine.The levels of neuron-specific enolase (NSE) and S100 β protein in peripheral veins of the two groups were detected and compared by enzyme-linked immunosorbent assay at 0.5 h (T0) before operation, at the end of operation (T1), at 6 h (T2) after operation and at 1 d(T3) after operation.The cognitive function of the two groups was evaluated and compared by mini-mental state examination (MMSE).Results There was no significant difference in the levels of NSE and S100β protein at T0 between the two groups (P＞0.05).The levels of NSE and S100β protein at T1, T2, and T3 were higher than those at T0 in both groups,the NSE and S100β protein levels in the experimental group at T1, T2, and T3 were lower than those in the control group, the differences were statistically significant (P＜0.05).There was no significant difference in MMSE scores between the two groups 1 d before surgery (P＞0.05).The MMSE scores at 1 and 3 days after surgery were lower in the two groups than at 1 day before surgery, the MMSE score of the experimental group was higher than that of the control group at 1 and 3 days after operation, the differences were statistically significant (P＜0.05).Conclusion Dexmedetomidine sedation can reduce the levels of NSE and S100β protein at different time points in elderly patients with mild depression receiving combined spinal and epidural anesthesia, which can improve the short-term cognitive function of patients after surgery.It is worthy of clinical promotion and application.
2020 Vol. 27 (3): 138-141 [Abstract] ( 87 ) HTML (40 KB)  PDF  (0 KB)  ( 13 )
142 Influence of optimizing photographic parameters on the quality and safety of bedside chest digital X-ray photography
HU Lu-nv； WU Yan

Objective To explore the effect of optimizing radiation dose on the quality and safety of bedside chest digital X-ray photography (DR).Method A total of 120 patients who underwent bedside DR examination in our hospital from December 2016 to December 2018 were selected as the research objects and randomly divided into control group and observation group, 60 patients in each group.The control group selected DR conventional photography parameters,while the observation group selected optimized photography parameters.The quality and scores of DR chest radiographs of the two groups of patients were compared, and the radiation doses received by the two groups of patients were compared.Results There was no significant difference in DR chest radiograph quality and score between the two groups(P＞0.05).The radiation dose of patients in the observation group was (0.136±0.017) mGy, which was lower than that of the control group ([0.382±0.025]mGy), and the difference was statistically significant (P＜0.05).Conclusion The optimized photography parameters can reduce the radiation dose and have little influence on the image quality, making the bedside chest DR safer.
2020 Vol. 27 (3): 142-144 [Abstract] ( 71 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
145 Application value of mammography combined with MRI in diagnosis of breast cancer in middle-aged and elderly patients
WANG Jia-xin； CHEN Yu-zhan； CHEN Yi-shuang； PENG Xiao-rong； FANG Xi-xin
Objective To explore the value of mammography combined with MRI in the diagnosis of breast cancer in middle-aged and elderly people.Methods From March 2017 to August 2018, 60 cases of middle-aged and elderly breast tumor patients admitted to our hospital were selected as research objects.All patients underwent mammography and MRI examination, with pathological examination as the gold standard.To compare the sensitivity, specificity and accuracy of mammography, MRI and mammography combined MRI in breast cancer detection.Results The sensitivity,specificity and accuracy of mammography were 56.25%, 53.57% and 55.00% respectively.The sensitivity, specificity and accuracy of MRI diagnosis were 62.50%, 67.86% and 65.00% respectively.The sensitivity, specificity and accuracy of mammography combined with MRI were 84.38%, 92.86% and 88.33% respectively.The sensitivity, specificity and accuracy of mammography combined with MRI in breast cancer detection were higher than those of single examination, and the differences were statistically significant (P＜0.05).There were no significant difference in sensitivity,specificity and accuracy between mammography and MRI (P＞0.05).Conclusion Compared with mammography and MRI alone, mammography combined with MRI has stronger detection ability, higher diagnostic accuracy, sensitivity and specificity for middle-aged and elderly breast cancer, which is worthy of clinical application and promotion.
2020 Vol. 27 (3): 145-147 [Abstract] ( 76 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
148 Application value of ultrasonography in selection of delivery methods for scar uterus pregnancy
PAN Xiao-hua
Objective To explore the application value of ultrasound examination in the choice of delivery mode for scar uterus pregnancy.Methods A total of 60 cases of pregnant women with scar uterus admitted to our center from January 2017 to December 2018 were selected as research objects.According to different ultrasonic examination results, they were divided into grade Ⅰ, Ⅱ, Ⅲand Ⅳscar groups, there were 20, 20, 10, 10 cases respectively.And 60 normal parturients in the same period admitted to our center were selected as the control group.The delivery methods,operation-related indexes, postoperative complications, neonatal asphyxia and the thickness of the lower uterine forearm were compared among the groups.Results The cesarean section rate of grade Ⅱ, Ⅲand Ⅳscar group were higher than that of the control group and grade Ⅰscar group,the differences were statistically significant(P＜0.05).The intraoperative blood loss and 24 h postpartum blood loss of parturients in grade Ⅱ, Ⅲand Ⅳscar group were all higher than those in the control group and grade Ⅰscar group, the operation time were longer than that in the control group and grade Ⅰscar group, the incidence of incomplete uterine rupture were higher than that in the control group and gradeⅠscar group, and the incidence of poor incision healing were higher than that in the control group, with statistically significant differences (P＜0.05).The total incidence of neonatal asphyxia in grade Ⅲand Ⅳscar group were higher than that in other groups, and the differences were statistically significant (P＜0.05).Compared with the thickness of the lower segment of the anterior wall of uterus, grade Ⅳscar group ＜gradeⅢscar group ＜grade Ⅱscar group ＜grade I scar group ＜control group, the differences were statistically significant (P＜0.05).Conclusion Ultrasonic examination technology has guiding significance in the choice of delivery mode for pregnant women with scar uterus, and is worthy of application and promotion.
2020 Vol. 27 (3): 148-151 [Abstract] ( 69 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
152 Application effect of modified Xuefu Zhuyu Decoction in conservative treatment of acute myocardial infarction
WU Xiu-feng； ZHANG Xin-yan； LI Yu-mei
Objective To investigate the application effect of modified Xuefu Zhuyu Decoction in conservative treatment of acute myocardial infarction.Methods A total of 100 patients with acute myocardial infarction admitted to our hospital from August 2017 to August 2018 were selected as the research subjects, they were divided into control group(50 cases) and the treatment group (50 cases) according to the random grouping method.The control group was given conventional western medicine treatment, the treatment group was given traditional Chinese and western medicine therapy, and the Xuefu Zhuyu Decoction was taken orally on the basis of the control group, the treatment was given for 3 weeks and followed up for 6 months.The total incidence of complications after treatment, cardiac function index, blood pressure index, C-reactive protein, white blood cell count, myoglobin, aspartate aminotransferase and brain natriuretic peptide levels before and after treatment were compared between the two groups.Results The total incidence of complications in the treatment group was lower than that in the control group, the difference was statistically significant (P＜0.05).There were no significant differences in heart rate, diastolic blood pressure and systolic blood pressure between the two groups after treatment (P＞0.05).The left ventricular ejection fraction in the treatment group was higher than that in the control group, and the levels of C-reactive protein, white blood cell count, myoglobin, aspartate aminotransferase, and brain natriuretic peptide were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The conservative treatment of patients with acute myocardial infarction with Xuefu Zhuyu Decoction combined with western medicine can reduce the incidence of complications after treatment, improve the patients′ left ventricular ejection fraction and clinical related indicators, reduce the related indicators of inflammatory response, which is worth clinical promotion and application.
2020 Vol. 27 (3): 152-154转158 [Abstract] ( 92 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
155 Clinical effect of traditional Chinese medicine acupuncture and moxibustion combined with rehabilitation training in the treatment of hemiplegia after cerebral apoplexy
ZHANG Jun； ZHENG Wu-xi
Objective To explore the clinical effect of traditional Chinese medicine (TCM) acupuncture and moxibustion combined with rehabilitation training in the treatment of hemiplegia after cerebral apoplexy.Methods A total of 60 hemiplegia after cerebral apoplexy patients admitted to our hospital from January 2017 to October 2018 were selected as the study objects, they were divided into control group and observation group according to the random number table method, with 30 cases in each group.The control group received routine rehabilitation treatment, and the observation group received TCM acupuncture and moxibustion treatment on the basis of the control group.The degree of nerve function defect, muscle strength, limb motor function, daily living ability and quality of life between the two groups were compared.Results After treatment, the national institutes of health stroke scale (NIHSS) scores of the two groups were lower than those before treatment, while the NIHSS scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).After treatment, the manual muscal test (MMT),Fugle-Meyer motor fuction scale (FMA), activities of daily living (ADL) scores of the two groups were higher than those before treatment, while the MMT, FMA, ADL scores of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).After treatment, the scores in the fields of physiological,psychological, environmental and social relations of the two groups were higher than those before treatment, and the scores in the observation group were higher than those in the control group, with statistically significant differences (P＜0.05).Conclusion TCM acupuncture and moxibustion combined with rehabilitation therapy can effectively improve the neurological function, muscle strength, limb function and ADL of cerebral apoplexy patients with hemiplegia, which is beneficial to the improvement of their quality of life.
2020 Vol. 27 (3): 155-158 [Abstract] ( 80 ) HTML (34 KB)  PDF  (0 KB)  ( 16 )
159 Expression and clinical significance of D-dimer in plasma of gestational diabetes patients
QIU Xiao-jun； CHEN Ying
Objective To investigate the expression and clinical significance of D-dimer (D-D) in the plasma of patients with gestational diabetes mellitus (GDM).Methods Seventy-two GDM patients admitted to our department of obstetrics and gynecology from March 2017 to September 2018 were selected as the GDM group, and 70 normal pregnant women during the same period were selected as the healthy group.The levels of plasma D-D and anti-thrombin Ⅲ(AT-Ⅲ) in GDM group and healthy group were compared.GDM group was divided into group with dood prognosis and group with poor prognosis according to the prognosis of parturient and newborn, the incidence of pregnancy complications and the level of plasma D-D were compared between the two groups.Results The level of plasma D-D in GDM group was higher than that in healthy group, and the level of AT-Ⅲwas lower than that in healthy group, the differences were statistically significant (P＜0.05).The level of plasma D-D in GDM group after treatment was lower than that before treatment, the difference was statistically significant (P＜0.05).The incidence of macrosomia, premature delivery and premature rupture of membranes in the group with good prognosis was lower than that in the group with poor prognosis, and the level of D-D was lower than that in the group with poor prognosis, the differences were statistically significant (P＜0.05).Conclusion The plasma D-D level of GDM patients is higher, and the change of D-D level is of great significance in the occurrence and development of the disease and the prognosis evaluation.
2020 Vol. 27 (3): 159-161 [Abstract] ( 73 ) HTML (30 KB)  PDF  (0 KB)  ( 15 )
162 Application value of routine urine test in the diagnosis of kidney diseases
GUAN Xi-hua
Objective To explore the application value of routine urine test in the diagnosis of kidney diseases.Methods A total of 200 patients with suspected kidney disease admitted to our hospital from January 2018 to May 2019 were selected as the study objects, all patients were diagnosed by routine urine test and microscopic examination.The red blood cell (RBC) count, morphological classification, occult blood test, renal tubular epithelial cell (REP) detection, urine protein qualitative test, sensitivity and specificity of the two methods were compared.Results RBC count and RBC deformation in routine urine test were higher than those in microscope test, RBC homogeneity was lower than that in microscope test, the differences were statistically significant (P<0.05).The ＞4/HP RBC count, positive rates of occult blood test and REP in routine urine test were higher than those in microscope test, the differences were statistically significant (P<0.05).The urinary protein qualitative test of routine urine test was higher than that of microscope test, the difference was statistically significant (P<0.05).The sensitivity and specificity of routine urine tests were higher than those of microscope tests, the differences were statistically significant (P<0.05).Conclusion Routine urine test has a higher application value in the diagnosis of kidney diseases, and can accurately detect RBC count, RBC deformation, and RBC uniformity, and the results of occult blood test, REP test and qualitative urine protein test are more obvious, and have higher sensitivity And specificity can provide a reference for clinical treatment.
2020 Vol. 27 (3): 162-164 [Abstract] ( 77 ) HTML (31 KB)  PDF  (0 KB)  ( 11 )
165 Analysis of the correlation between homocysteine, folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome
12 levels and the risk factors of adverse pregnancy outcome[J]. 中国当代医药, 2020,27(3): 165-167')" href="#"> LI Chao-hui； HU Ya； OU Min-yi； HUANG Wei-jian； CAO Zi-jie
Objective To investigate the correlation between homocysteine, folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome.Methods A total of 50 pregnant women with adverse pregnancy outcome from June 2017 to June 2018 were selected as the study group, and 50 pregnant women with no adverse pregnancy outcome in the same time period were selected as the control group.The results of serum test were observed and compared, and the correlation between homocysteine and folic acid and vitamin B12 levels was analyzed, and the risk factors related to adverse pregnancy were analyzed by unconditional Logistic multiple stepwise regression analysis.Results The homocysteine in the study group was (11.20±2.85) μmol/L, which was higher than that in the control group (9.35±1.02)μmol/L, and the difference was statistically significant (P＜0.05).The folic acid index in the study group was (6.10±1.55) ng/ml, lower than that in the control group (6.95±1.68) ng/ml, and the difference was statistically significant (P＜0.05).The vitamin B12 index in the study group was (78.30±28.75) pg/ml, which was lower than that in the control group (98.35 ±45.50) pg/ml, and the difference was statistically significant (P＜0.05).The results of Pearson correlation analysis showed that there was a negative correlation between serum homocysteine level and folic acid (r=-0.088, P=0.000).The serum homocysteine level was negatively correlated with the level of vitamin B12 (r=-0.109, P=0.001).Non-conditional Logistic multivariate regression analysis showed that the increase of homocysteine, the decrease of vitamin B12 and the decrease of folic acid were all risk factors of adverse pregnancy (β=0.541, OR=1.708, 95%CI=0.039-1.895, P＜0.05; β=0.003, OR=1.001, 95%CI=0.001-1.109, P＜0.05; β=0.004, OR=1.002, 95%CI=0.001-1.010, P＜0.05).Conclusion The related risk factors of adverse pregnancy outcome include the increase of homocysteine, the decrease of vitamin B12 level and the decrease of folic acid.Therefore, combined with the situation of pregnant women, the monitoring of homocysteinemia, vitamin B12 and folic acid levels should be strengthen in order to effectively prevent the adverse pregnancy outcome.
2020 Vol. 27 (3): 165-167 [Abstract] ( 76 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
168 Study on the value and results of prenatal immunology test
WU Yan-mei
Objective To discuss the value of prenatal immunization test.Methods From January to December 2018,200 cases of maternal women admitted to our hospital were selected as the subjects of study.They were divided into control group (100 cases) and research group (100 cases) according to the computer random method.The control group received the regular prenatal examination, that was, the first pregnancy test at 16-20 weeks, and then received a routine pregnancy examination every 4 weeks, but did not receive an immunology test.The research group received routine prenatal test + immunology test, that was, the first pregnancy test at 16-20 weeks, and then received a routine pregnancy test every 4 weeks and immunology test, until the end of delivery.The positive detection rate of immunology test indexes, the incidence rate of high risk pregnancy, the delivery mode and the incidence rate of adverse events were compared between the two groups.Results The positive detection rate of maternal immunology test in the study group was 12% higher than that in the control group, with statistically significant difference (χ2=4.3478, P=0.0370).The incidence of high-risk pregnancy in the study group was 11%, lower than that in the control group for 22%, with statistically significant difference (χ2=4.3912, P=0.0361).The natural delivery rate of parturients in the study group was 80%, which was higher than that of the control group by 50%, with statistically significant difference (χ2=19.7802, P=0.0000).The incidence of adverse events in the study group was 0%, lower than that in the control group for 5%, with statistically significant difference (χ2=5.1282, P=0.0235).Conclusion Compared with routine prenatal examination, prenatal immunology test can further understand the basic conditions of maternal in detail, so that timely intervention measures can be taken to improve the quality of maternal delivery.
2020 Vol. 27 (3): 168-170 [Abstract] ( 77 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
171 Analysis of pathogenic bacteria distribution and drug resistance in the fourth quarter of 2017 in our hospital
WU Xiang-feng； HUANG Liang； TIAN Wen-fang； TANG Xi-jun
Objective To analyze the pathogenic bacteria distribution and drug resistance in the fourth quarter of 2017 in our hospital.Methods A total of 2262 specimens submitted for inspections in the fourth quarter of 2017 in our hospital were statistically analyzed, including wards and outpatient clinic, the re-inspection specimens were also covered.Results A total of 390 pathogenic bacteria were detected, of which 220 were Gram-negative bacteria, accounting for 56.41%.The top three were Escherichia coli (27.18%), Klebsiella pneumoniae (10.51%) and Pseudomonas aeruginosa(9.74%).The resistance rates of Pseudomonas aeruginosa and Acinetobacter baumannii to Carbapenems such as Imipenem were 42.86% and 68.75%, respectively.Conclusion In 2017, Gram-negative bacteria resistance in our hospital resistant to Carbapenems such as Imipenem mainly includes bacteria of enterobacteriaceae, multi-drug resistant Acinetobacter baumannii and multi-drug resistant Pseudomonas aeruginosa.Drug resistance monitoring is beneficial for guiding clinical rational drug use, providing a basis for epidemiological investigation of pathogens and rational use of antibiotics.
2020 Vol. 27 (3): 171-173转180 [Abstract] ( 71 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
174 Analysis of the influencing factors of quality of life in patients with chronic hepatitis C
ZHU Ren-ying； ZHAO Yu-mei； LI Yue； WANG Li-li； AN Yun-feng； HUANG Shuang-li
Objective To analyze the influencing factors of quality of life in patients with chronic hepatitis C in order to provide references for the optimization of treatment regimens.Methods A total of 536 patients with chronic hepatitis C (including 7 cases of shedding) in Hongqi hospital Affiliated to Mudanjiang Medical College from January 2016 to December 2017 were selected as the research objects.All patients were treated with the same antiviral regimen.Before and after treatment, the quality of life of the patients was evaluated by using the health status survey, and the data such as gender and educational level of the patients were investigated and collected to analyze the influencing factors.Results The results of univariate analysis indicated that there were statistically significant differences in the education level, monthly economic income, hobbies, marital status and residence status between the group with good quality of life and the group with poor quality of life (P＜0.05).The results of Logistic multivariate analysis indicate that education level (β=2.372, OR=12.125, 95%CI 5.125-33.256), monthly economic income (β=1.050, OR=2.851, 95%CI 1.358-7.226), hobbies (β=2.376, OR=14.265, 95%CI 4.568-31.265), marital status (β=2.595, OR=15.233, 95%CI 4.215-30.235) and living conditions (β=2.602, OR=15.389, 95%CI 4.189-33.358) were related factors affecting the quality of life of patients with chronic hepatitis C (P＜0.05).Conclusion The factors influencing the quality of life of patients with hepatitis C are complex, mainly including education level, monthly economic income, hobbies, marital status and living conditions, etc.It is suggested that doctors should pay attention to the above factors to further improve the rehabilitation effect of patients.
2020 Vol. 27 (3): 174-176 [Abstract] ( 90 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
177 Investigation and analysis on the knowledge, attitude and behavior status of breast health care of women in physical examination in our hospital
KE Xiao-xuan； FAN Hai-ling
Objective To analyze the knowledge, attitude and behavior status of breast health care of women in physical examination in our hospital.Methods A total of 50 women who were examined in our hospital from February 10,2018 to January 1, 2019 were selected for investigation.The breast health care knowledge, ways to get, attitude and behavior status of the women were analyzed.Results There was significant difference in the knowledge of breast health care among women of different ages (P＜0.05).There was no significant difference in the knowledge of breast health among women with different educational background, marital status and lactation history (P＞0.05).The main way to obtain breast health knowledge of 50 physical examination women was from television, accounting for 60.00%, followed by internet (52.00%), newspapers (48.00%), doctors (36.00%), books (18.00%), family members or friends (18.00%).Among 50 medical examinations women, the scores of breast health knowledge and attitude were (9.21±0.15) points and(8.23±1.27) points.About 60% of women never paid attention to their breasts.24% of women didn′t fully know the breast care knowledge.16% of women knew that breast discomfort was closely related to their own menstrual cycle.Among the 50 women, only 10 women did self-examinations on their breast, accounting for 20.00%.Conclusion Women for physical examinations have low levels of knowledge about breasts.It is necessary to enhance the publicity of breast knowledge, and focus on disease health education, strengthen the self examination behavior of female mammary gland,so as to prevent the occurrence of breast cancer.
2020 Vol. 27 (3): 177-180 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
181 The practical effect of "one-stop service center" in outpatient clinic of our hospital
WAN Meng-chao； LI Shu-mei； XUE Shan； LAN Xin
Objective To improve the quality of outpatient service and provide high-quality, efficient, convenient and comprehensive services for patients.Methods A total of 800 outpatients admitted to our hospital from January 2018 to January 2019 were selected as the research objects.They were divided into control group (400 cases) and experimental group (400 cases) according to the order of admission.The control group adopted the routine nursing service method,while the experimental group adopted the "one-stop" service method.The two groups were compared in terms of satisfaction and average visit time.Results After the intervention, the satisfaction of the experimental group was higher than that of the control group, with statistical significance (P＜0.05).After the intervention, the average visiting time of the patients in the experimental group were shorter than those of the control group, and the difference was statistically significant (P＜0.05).Conclusion The reformed outpatient service "one-stop service center" has played an important role in improving service levels, simplifying outpatient visits and procedures, saving precious time for patients, improving patients′ sense of medical treatment and satisfaction, and also embodying the spirit of high-quality, efficient and convenient humanistic service.
2020 Vol. 27 (3): 181-183 [Abstract] ( 71 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
184 Challenges and countermeasures faced by hospital information construction in intelligent times
HUANG Yong
With the continuous development and advancement of computer technology, in order to improve the level of routine management, hospitals must actively integrate the level of informationization, strengthen the comprehensive value of information interaction management, and lay the foundation for the hospital to build a good service model.Although most hospitals have recognized the importance of informatization construction, and have begun to gradually implement the corresponding treatment plan, there are still some problems that need to be solved urgently, which need to be highly concerned by department management.This paper analyzes the problems existing in the current hospital information construction, and discusses the relevant optimization measures for reference only.
2020 Vol. 27 (3): 184-186 [Abstract] ( 85 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
187 Comparison of the cleaning and disinfection effect of manual cleaning and cleaning machine on the ventilator external pipeline after use
LIU Fang； LI Li-hua； LI Wei； CHEN Miao-ling
Objective To investigate the cleaning and disinfection effect of manual cleaning and cleaning machine on the ventilator external pipeline after use.Methods A total of 108 pieces of ventilator external pipeline after use which was in our hospital from December 2017 to December 2018 were selected.All the external pipelines were divided into the experimental group and the control group according to the random number table method, with 54 pieces in each group.The control group used manual cleaning and disinfection, while the experimental group used cleaning machine for cleaning and disfection.The bacteriology inspection situation, cleanliness, and the average time to clean one external pipeline of the external pipelines after cleaning and disinfection were compared.Results There were no statistically significant differences between the two groups in the detection results of external pipe bacteriology at the end of the cleaning and after cleaning and preservation for 1 month (P＞0.05).There was no significant difference in cleanliness and dryness between the two groups (P＞0.05).The average time to clean one external pipeline of the external pipelines in the experimental group was (2.41±0.37) min, which was lower than that in the control group ([3.92±0.64]min), and the difference was statistically significant (P＜0.05).Conclusion Manual cleaning and disinfection of the ventilator external pipeline has the same effect as washing and disinfection of the cleaning machine, and the cleaning and disinfection quality is reliable.However, the washing and disinfection of the cleaning machine in batch can significantly reduce the average time consumption, which can be used as the preferred way of cleaning and disinfection of the hospitals′ external pipelines.
2020 Vol. 27 (3): 187-189 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
190 A survey of life events, mental resilience and loneliness of migrant children in junior middle school
HE Yu-min； CHEN Hui-ling
Objective To analyse the situation of life events, psychological flexibility and loneliness of migrant children in junior middle school.Methods A total of 120 junior middle school migrant children admitted to a school from January 2017 to October 2018 were selected as the observation group, and another batch of 120 junior middle school children in the same period were selected as the control group.The scores of life event, psychological resilience and loneliness of the two groups were observed.The mental resilience scores of migrant children in different grades were compared.Results The scores and total score of life events in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).The scores and total score of psychological resilience in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).The loneliness score of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The scores and total score of psychological resilience of the migrant children in grade two were higher than those of the migrant children in grade one, and the differences were statistically significant (P＜0.05).Conclusion Changes in social structure caused by mobility can increase the loneliness of migrant children to a certain extent, and then lead to negative emotions.Therefore, it is necessary to pay special attention to the mental health of migrant children, especially in the lower grades.
2020 Vol. 27 (3): 190-192 [Abstract] ( 82 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
193 Exploration of integrating specialized courses combining ideological and political education into the teaching of "pharmaceutics of traditional Chinese medicine"
HUANG Hua-hua； WANG Ming-jun； QIN Ze-hui； ZHENG Cai-mei
In response to the overall goal of education "carrying out ideological and political work throughout the entire process of education and teaching, realizing the whole process of educating people and educating people in all directions", which was proposed at the National College Ideological and Political Work Conference, taking the core course for traditional Chinese pharmacology specialty "pharmaceutics of traditional Chinese medicine" (pharmaceutics of TCM) as an example, this study analyzes the necessity of integrating specialized courses combining ideological and political education into the teaching of pharmaceutics of TCM from specialty and course, and discusses several integration points.This attempt really makes the specialized courses become the base of students' ideological and political education.At the same time students receive traditional Chinese medicine culture education, moral education, professional quality education and innovation cooperation education while learning their specialized courses.
2020 Vol. 27 (3): 193-195 [Abstract] ( 85 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
196 Innovation research on the daily ideological and political education of medical postgraduates in the context of collaboration between medicine and education
ZHAO Jing-yuan
The medical postgraduates cultivation aims at systematic education of professional talents.And the dual task of medical postgraduates including resident training and courses learning specialize their daily ideological and political education，which makes it more difficult for political assistants to conduct the work successfully in the context of collaboration between medicine and education.Therefore, political assistants should increase the ideological understanding and strengthen the practice education to innovate the work.
2020 Vol. 27 (3): 196-198转202 [Abstract] ( 64 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
199 Analysis on the challenges and countermeasures of standardized training for residents in the Pediatric Neurology
GUO Zhen-hua； WANG Yi； HONG Si-qi
The standardized training of residents is a transitional stage for medical students from school to clinic, and it is an important stage to improve the thinking and judgment ability of clinicians.The department of pediatric neurology is very professional, involving many disciplines, the relevant theoretical knowledge is complex and abstract, and the progress of clinical diagnosis and treatment is updated rapidly, standardized training doctors are prone to "nervous fear", resulting in fear of difficulties and a decline in interest of learning.The quality of training is difficult to guarantee.As the only standardized training and demonstration base for paediatric residents in China, the Children′s Hospital Affiliated to Chongqing Medical University has been responsible for the training of pediatric neurologists at all levels for many years, and has accumulated abundant teaching experience.This paper summarizes the experience of standardized training of residents in the department of neurology in our hospital, introduces the relevant teaching ideas and teaching methods in detail, to provide experience for improving the quality of standardized training of residents in the department of neurology in children.
2020 Vol. 27 (3): 199-202 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
203 Effect of prone position combined with touch intervention on feeding intolerance in premature low birth weight infants
ZHAO Xiao-yan
Objective To investigate the effect of prone position combined with touch intervention on feeding intolerance in premature low birth weight infants.Methods A total of 200 children with premature low birth weight who were admitted to our hospital from March 2016 to May 2019 were selected as subjects, they were divided into control group and observation group according to the random number table method, with 100 cases in each group.The control group received routine care, and the observation group performed a prone position combined with touch intervention.The duration of feeding intolerance, the time required to restore birth weight, the time of adequate gastrointestinal feeding, the time of bloating, vomiting and gastric retention disappeared were compared.The growth and development of the two groups and the incidence of complications were recorded.Results The duration of feeding intolerance, the time required to restore birth weight, and the time to achieve adequate gastrointestinal feeding were (6.53±1.24), (13.11±2.34),and (12.58±2.28) d, both shorter than the (8.56±1.13), (14.22±2.19), (18.67±3.54) d in the control group, the differences were statistically significant (P＜0.05).The disappearance time of bloating, vomiting and gastric retention in the observation group was (3.75±1.46), (4.13±1.01), (4.38±1.19) d, which were shorter than the (5.63±2.27), (4.74±1.43), (6.89±2.56) d in the control group, the differences were statistically significant (P＜0.05).After intervention, the weight of the observation group was (2583.33±201.42) g, which was higher than that of the control group for (2372.52±284.32) g, and the difference was statistically significant (P＜0.05).After intervention, the body lengthand head circumference of the observation group were (47.53±2.94) and (32.94±2.75) cm, which were longer than the (45.73±2.56) and (31.34±1.73) cm in the control group, the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group was 9.00%, which was lower than the 21.00% in the control group, and the difference was statistically significant (P＜0.05).Conclusion Prone position combined with touch intervention can improve the feeding intolerance of premature low birth weight infants, which can effectively promote the growth and development of children and reduce the incidence of complications.
2020 Vol. 27 (3): 203-206 [Abstract] ( 75 ) HTML (38 KB)  PDF  (0 KB)  ( 16 )
207 Application of high quality nursing in nursing care of secondary hypertension complicated with cerebral hemorrhage
WU Yu-bao； LI Zhu-hua； LIU Gui-xiang
Objective To explore the effect of high quality nursing in nursing care of secondary hypertension complicated with cerebral hemorrhage.Methods From January 2017 to December 2018, 100 patients with secondary hypertension complicated with cerebral hemorrhage were selected and divided into control group (n=50) and observation group (n=50) by drawing lots.The control group was treated with routine nursing, and the observation group was treated with high quality nursing on the basis of control group nursing.The quality of life and self-rating anxiety scale (SAS),self-rating depression scale (SDS) scores and satisfaction were compared between the two groups before and after nursing intervention.Results Before nursing intervention, there was no significant difference in quality of life score, SAS and SDS scores between the two groups (P＞0.05).After nursing intervention, the quality of life scores of the two groups were higher than that before nursing intervention, and the SAS and SDS scores were lower than those before nursing intervention, the differences were statistically significant (P<0.05).The quality of life score of the observation group was higher than that of the control group, and the SAS and SDS scores of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05).The overall satisfaction rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion In the nursing process of patients with secondary hypertension complicated with cerebral hemorrhage, high quality nursing can improve the quality of life of patients, reduce the bad psychology of patients, and improve the satisfaction of patients,which is worth popularizing.
2020 Vol. 27 (3): 207-209 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 16 )
210 Application of intermittent oral-esophageal feeding technology in stroke patients with dysphagia
LIU Mei-qing； LIU Xiao-jing ； WU Jian-fen； DENG Hui-fang
Objective To investigate the application effect of intermittent oral-esophageal feeding (IOE) technology in stroke (CAV) patients with dysphagia.Methods A total of 50 cases of stroke CAV patients with dysphagia treated in our hospital from November 2018 to March 2019 were selected as the study subjects.They were divided into control group (n=25) and experimental group (n=25) according to the random number table method.The control group was fed with nasal feeding tube, while the experimental group was fed with IOE technology.The improvement of swallowing function after 1 and 2 weeks of treatment was compared between the two groups, and the hospitalization time and complications of the two groups were recorded.Results The total effective rates of swallowing function improvement in the experimental group after 1 and 2 weeks of treatment were higher than those in the control group, and the differences were statistically significant (P<0.05).The hospitalization time of the experimental group was shorter than that in the control group, and the difference was statistically significant (P<0.05).The total incidence of complications in the experimental group was lower than that in the control group, the difference was statistically significant (P<0.05).Conclusion IOE technology can significantly shorten the hospitalization time of CAV patients with dysphagia, improve their swallowing function and reduce the incidence of complications.
2020 Vol. 27 (3): 210-212 [Abstract] ( 80 ) HTML (32 KB)  PDF  (0 KB)  ( 18 )
213 Application effect of comprehensive nursing mode in patients with femoral intertrochanteric fracture
YANG Fan； PENG Xiao-yu； YANG Hui-ping
Objective To explore the effect of comprehensive nursing mode in patients with femoral intertrochanteric fractures.Methods A total of 56 patients with femoral intertrochanteric fractures who were treated in our hospital from May 2017 to April 2019 were enrolled.They were equally divided into the reference group and the experimental group,28 cases in each group.The reference group used the traditional nursing mode, and the experimental group adopted the comprehensive nursing mode.The postoperative pain score, hip joint activity, and total nursing satisfaction were compared between two groups.Results The postoperative pain score of the experimental group was lower than that of the reference group, and the hip joint activity was larger than that of the reference group, with statistical difference (P<0.05).The total satisfaction of the experimental group was higher than that of the reference group, with statistical difference (P<0.05).Conclusion In patients with femoral intertrochanteric fractures, the comprehensive nursing mode can be promoted for it not only alleviates postoperative pain, but also enhances hip joint mobility, and improves doctor-patient relationship as well as nurse-patient relationship.
2020 Vol. 27 (3): 213-215 [Abstract] ( 80 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
216 Effect of Heartleaf Houttuynia herbal bath combined with Mupirocin Ointment in the treatment of neonatal toxic erythema
LU Rui-ying; LIU Gui-rong; ZHONG Su-qin
Objective To investigate the clinical effect of Heartleaf Houttuynia herbal bath combined with Mupirocin Ointment in the treatment of neonatal toxic erythema.Methods Sixty neonates with neonatal toxic erythema after birth in our hospital from July 2017 to July 2018 were enrolled in the study and were divided into control group (n=30) and observation group (n=30) according to random number table method.The control group was bathed in warm water, while the observation group was treated with Heartleaf Houttuynia herbal bath and Mupirocin Ointment.The therapeutic effect, erythema dissipating time and impetigo condition between the two groups were compared.Results The erythema dissipating time in the observation group was shorter than that in the control group, the difference was statistically significant (P＜0.05).The incidence of impetigo in the observation group (0/30), lower than that in the control group (9/30),the difference was statistically significant (P＜0.05).The total effective rate of the observation group was 96.67%, higher than that of the control group accounting for 80.00%, the difference was statistically significant (P＜0.05).Conclusion For neonatal with neonatal toxic erythema, application of Heartleaf Houttuynia herbal bath combined with Mupirocin Ointment is effective, which can not only shorten the time of erythema dissipation, but also reduce the occurrence of impetigo, and has higher clinical application value.
2020 Vol. 27 (3): 216-218 [Abstract] ( 86 ) HTML (30 KB)  PDF  (0 KB)  ( 15 )
219 Effect of evidence-based nursing on self-efficacy and negative emotions in patients with diabetic peripheral neuropathy
YANG Jian-hui； QIU Shu-huan； CHEN Dong-cheng； SU Jia-yi
Objective To investigate the effects of evidence-based nursing on self-efficacy and negative emotions in patients with diabetic peripheral neuropathy (DPN).Methods A total of 56 patients with DPN who were treated in our hospital from January to September in 2018 were enrolled as subjects.By random number table method, they were divided into the control group and the observation group, 28 cases in each group.The control group received routine nursing and the observation group provided with evidence-based nursing.The improved effects of neurological function of foot, self-efficacy and negative emotion were compared between the two groups.Results Before the intervention,there were no significant differences between the two groups in the Toronto clinical score system (TCSS), the diabetes self-efficacy scale (DSES), the self-rating depression scale (SDS), and the self-rating anxiety scale (SAS) score (P＞0.05).After intervention, the scores of TCSS, SDS and SAS of the observation group were lower than those of the control group (P＜0.05), and the DSES score was higher than that of the control group, the differences were statistically significant (P＜0.05).Conclusion Evidence-based nursing can improve the negative emotions of patients with DPN and their self-efficacy and neurological function of foot.Compared with routine nursing, its intervention effect is better.
2020 Vol. 27 (3): 219-221转225 [Abstract] ( 80 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
222 Effect of whole-course nursing intervention on children′s video electroencephalogram monitoring artifacts
LIU Li
Objective To explore the effect of whole-course nursing interventions on artifacts in children′s video electroencephalogram (V-EEG) monitoring.Methods A total of 135 children with epilepsy who underwent V-EEG examination in Peace Hospital Affiliated to Changzhi Medical College from December, 2017 to December, 2018 were selected as study objects.They were divided into observation group and control group according to the examination time.The control group included 66 outpatient children monitored from December, 2017 to June, 2018, and the observation group included 69 hospitalized children from July, 2018 to December, 2018.Among them, routine nursing intervention was conducted before V-EEG examination in the control group, and whole-course nursing intervention was conducted in the observation group on the basis of routine nursing intervention.The success rate of electroencephalogram monitoring and the incidence of false difference in the two groups were compared, and the reasons for unsuccessful monitoring were recorded.Results Emotional instability, electromagnetic wireless signal interference and repeated electrode shedding were the main causes of monitoring failure.The incidence of false positives in the observation group (13.0%) was lower than that in the control group (34.1%), and the difference was statistically significant (P<0.05).Conclusion The whole-course nursing intervention plays a significant role in the success of children′s V-EEG monitoring, which effectively reduces the incidence of artifacts during the examination, and provides a basis for subsequent diagnosis and treatment.
2020 Vol. 27 (3): 222-225 [Abstract] ( 68 ) HTML (39 KB)  PDF  (0 KB)  ( 11 )
226 Application effect of diversified nursing intervention in patients with hand and foot trauma
XU Mei-ying
Objective To explore the application effect of diversified nursing intervention in patients with hand and foot trauma.Methods A total of 116 cases of hand and foot trauma wounds admitted to our hospital from September 2016 to November 2018 were selected as study subjects.According to the stratified randomization method, they were divided into observation group (58 cases) and the control group (58 cases).The observation group used diversified nursing intervention, and the control group used traditional nursing intervention, the quality of life scores (life satisfaction, energy index, health index), complication rate, and functional recovery rate were compared between two groups.Results Life satisfaction, energy index and health index score of the observation group were higher than that of the control group,the differences were statistically significant (P<0.05).The incidence of complications in the observation group was lower than that of the control group, the difference was statistically significant (P<0.05).The excellent rate of functional recovery in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05).Conclusion Diversified nursing intervention methods can effectively reduce the incidence of complications in patients with hand and foot trauma, and ensure that patients′ function recovery is good.It is worthy of promotion.
2020 Vol. 27 (3): 226-228 [Abstract] ( 56 ) HTML (30 KB)  PDF  (0 KB)  ( 11 )
229 Application effect of comprehensive nursing intervention in patients with cardiac arrest caused by malignant arrhythmia
CHEN Bi-huan； CHEN Ren-hua
Objective To explore the application effect of comprehensive nursing intervention in patients with cardiac arrest caused by malignant arrhythmia.Methods From February 2017 to January 2019, 98 patients with cardiac arrest caused by malignant arrhythmia treated in our hospital were selected and randomly divided into control group (n=49)and observation group (n=49).The control group was treated with routine nursing method, and the observation group was treated with comprehensive nursing intervention.The success rate of rescue, the recovery time of vital signs and the quality of life of the two groups were compared.Results The initial rescue success rate and complete rescue success rate in the observation group were 81.63% and 57.14%, respectively, which were higher than those in the control group (38.78% and 20.41%), the differences were statistically significant (P<0.05).The recovery time of autologous circulation (40.27±9.45), autogous respiration (29.37±6.88) min, sinus rhythm (2.77±0.58)min, which were shorter than those of the control group (102.59±22.67), (146.34±31.37) and (5.13±1.20) min, the differences were statistically significant (P<0.05).Observation group consciousness (14.82±7.25), limb activity (16.81±5.76), social function (14.67±8.64)and environment field (12.38±5.24) point were higher than those in the control group (9.16±5.22), (11.03±4.28),(10.16±5.97) and (8.16±4.33) point, the differences were statistically significant (P<0.05).Conclusion Due to malignant arrhythmia, comprehensive nursing intervention can improve the success rate of initial rescue and complete rescue, and shorten the recovery time of vital signs, and the clinical effect is remarkable.
2020 Vol. 27 (3): 229-231 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 16 )
232 Application effect of continuous nursing in hysteroscopic surgery for patients with intrauterine adhesions and infertility
CHEN Xue-mei； GU Hai-yan
Objective To investigate the effect of continuous nursing on hysteroscopic nursing in patients with intrauterine adhesions and infertility.Methods A total of 76 patients with intrauterine adhesions and infertility who were admitted to our hospital from March 2018 to February 2019 were selected and divided into the conventional group and the study group according to random number table method, 38 cases in each group.The conventional group used the routine nursing mode, and the study group was combined with the continuous nursing model based on the routine group.The mental health, disease cognition and menstrual recovery were compared between the two groups.Complications and nursing satisfaction were compared between the two groups.Results The mental health, disease cognition and menstrual status of the study group were higher than those of the conventional group, the total incidence of complications in the study group was lower than that of the conventional group.Moreover, the nursing total satisfaction of the study group was higher than that of the conventional group, the differences were statistically significant (P<0.05).Conclusion Hysteroscopic surgery in patients with intrauterine adhesions and infertility develops a continuous nursing mode, which can effectively improve the patient′s psychological state, improve the awareness of the disease and satisfaction of the nursing, and the effect is obvious.
2020 Vol. 27 (3): 232-234 [Abstract] ( 72 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
235 Application effect of problem-oriented nursing intervention in patients with gestational diabetes mellitus
HUANG Xiao-li; CHEN Wen-mei
Objective To explore the effect of problem-oriented nursing intervention in patients with gestational diabetes mellitus (GDM).Methods A total of 80 patients with GDM admitted to Yunfu Maternal and Child Health and Family Planning Service Center from May 2018 to January 2019 were selected and divided into control group and observation group according to random number table method, 40 cases in each group.The control group received routine nursing intervention and the observation group received problem-oriented nursing intervention.The compliance behavior, blood glucose control and pregnancy outcome of the two groups were compared.Results Treatment compliance of observation group was higher than that of control group, the difference was statistically significant (P<0.05).The values of fasting blood glucose (Glu), 2 h postprandial blood glucose and glycosylated hemoglobin (HbA1c) in the observation group after nursing intervention were lower than those in the control group, with statistical differences (P<0.05).The incidence of adverse birth outcomes in the observation group was 15%, lower than that in the control group 50%, with statistical difference (P<0.05).Conclusion Treatment of patients with GDM combined with problem-oriented nursing intervention can improve patients′ medical compliance and significantly improve maternal pregnancy outcomes, which is worthy of clinical promotion.
2020 Vol. 27 (3): 235-237 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
238 Effect of mindfulness decompression nursing on negative emotions of elderly stroke patients with obstructive sleep apnea hypopnea syndrome
XUE Jun
Objective To explore the effect of mindfulness decompression nursing on negative emotions of elderly stroke(CAV)patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods From June 2017 to December 2018,84 elderly CAV patients with OSAHS admitted to our hospital were selected, they were divided into observation group(42 cases) and control group (42 cases) by random number table method.The control group received routine nursing,while the observation group received mindfulness decompression nursing.Hamilton anxiety scale（HAMA）score,Five facet mindfulness questionnaire（FFMQ）score and profile of mood states（POMS-SF）score were compared between two groups,to understand the patient′s anxiety, negative emotions.Results After intervention, HAMA score in the observation group were lower than that of the control group，the difference was statistically significant (P<0.05).The POMS score of observation group was lower than that of control group, the difference was statistically significant (P<0.05).FFMQ score was higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion Mindfulness decompression nursing can effectively reduce patients′ anxiety, improve mindfulness thinking and self-efficacy.
2020 Vol. 27 (3): 238-240 [Abstract] ( 85 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
241 Influence of motivated nursing on parturients delivery
HU Yang
Objective To explore the influence of motivated nursing on parturients delivery.Methods A total of 300 parturients who gave birth in our hospital from February 2018 to February 2019 were selected as the research object,who were divided into the observation group and the control group according to random number table method, 150 cases in each group.The control group was received traditional nursing, the observation group was received motivated nursing on the base of the control group.Methods of delivery, psychological state, duration of labor, and incidence of neonatal asphyxia were compared between the two groups.Results The rate of natural birth in the observation group was 91.33%, which was higher than that of the control group (80.67%), the difference was statistically significant (P＜0.05).The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The first duration of labor,the second duration of labor, the total duration of labor of the observation group were shorter than those of the control group, and the rate of neonatal asphyxia in the observation group was lower than that in the control group, the differences were statistically significant (P＜0.05).Conclusion Motivated nursing can improve the rate of natural birth, relieve negative motion, shortening labor process and reduce asphyxia rate of newborn and can be more used in clinical.
2020 Vol. 27 (3): 241-243转247 [Abstract] ( 79 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
244 Clinical application effect of new nursing mode of daily nursing combined with neonatal early education
LIU Xin-bo
Objective To explore the clinical effect of the new nursing mode of neonatal daily nursing combined with neonatal early education.Methods From October 2017 to October 2018, 60 newborns delivered in our hospital were selected and computer randomly divided into control groups and observation group, 30 cases in each group.The control group was given with daily nursing care.On the basis of the control group, the observation group was given with new nursing model of neonatal early education, the results of head circumference, body mass, height and neonatal neurobehavioral score (NBNA) were compared between the two groups.Results There was no significant difference in head circumference, body mass and height between the two groups at birth (P＞0.05), but the indexes of the two groups increased 3 months after discharge, but the head circumference, body mass and height of the observation group were greater than those of the control group, the differences were statistically significant (P<0.05).The behavioral ability,passive muscle tension, active muscle tension, original reflex, general reaction score and the total score of NBNA in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05)Conclusion The clinical application of the new nursing model of neonatal daily nursing combined with neonatal early education is good, which is beneficial to the development of newborn body and intelligence, and is worthy of clinical promotion.
2020 Vol. 27 (3): 244-247 [Abstract] ( 68 ) HTML (35 KB)  PDF  (0 KB)  ( 13 )
248 Effect of nursing model based on Omaha system theory on quality of life of elderly stroke patients
CHANG Yan
Objective To explore the effect of nursing model based on Omaha system theory on the quality of life of elderly stroke (CAV) patients.Methods A total of 158 elderly CAV patients in our hospital from January to December 2018 were selected as the research subjects, and all of them were divided into routine group and observation group according to random envelope method, 79 cases in each group.Patients in routine group were given routine nursing, while patients in observation group were given intervention management based on Omaha system theory.Modified Barthel index rating scale (BMI) and concise health survey scale (SF-36) were used to evaluate patients′ activities of daily living(ADL) and quality of life.Results There was no significant difference in ADL scores between the two groups before intervention (P＞0.05), and the ADL score of the observation group was lower than that of routine group after intervention,the differences were statistically significant(P<0.05).There were no significant difference in the scores of SF-36 between the two groups before intervention (P＞0.05), and the scores of SF-36 in the observation group were higher than those in the conventional group, the differences were statistically significant (P<0.05).Conclusion The nursing model based on Omaha system theory is helpful to improve the activity of daily life and the quality of life elderly CAV patients.
2020 Vol. 27 (3): 248-250 [Abstract] ( 73 ) HTML (31 KB)  PDF  (0 KB)  ( 11 )
251 Effect of nursing risk management in the prevention of falling and falling out of bed in senile patients
ZHANG Xiao-ling
Objective To analyze the application effect of nursing risk management in prevention of falling and falling out of bed in senile patients.Methods The clinical data of 94 senile patients who were admitted in our hospital from January 2017 to December 2018 were retrospectively analyzed.All patients were divided into control group and observation group according to the different nursing methods, 47 cases in each group.The control group was given routine nursing, and the observation group was given nursing risk management based on routine nursing.The incidence of falling, falling out of bed, total satisfaction were compared between the two groups.Results The total incidence of falling and falling out of bed in observation group was lower than that in control group, while the total nursing satisfaction in observation group was higher than that in control group, and the differences were statistically significant (P＜0.05).Conclusion Nursing risk management can prevent the falling and falling out of bed in senile patients, and increase nursing satisfaction.
2020 Vol. 27 (3): 251-253 [Abstract] ( 63 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
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