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| Effect of paravertebral block combined with general anesthesia on postoperative stress response in patients with colorectal cancer resection |
| DU Xue-jun |
| Department of Anesthesiology, Anshan Cancer Hospital, Liaoning Province, Anshan 114000, China |
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Abstract Objective To investigate the effect of paravertebral block combined with general anesthesia on postoperative stress response in patients with colorectal cancer resection.Methods A total of 200 patients with colorectal cancer resection admitted to our hospital from May 2016 to May 2018 were selected as the research objects.According to the method of drawing lots, they were divided into observation group (100 cases) and control group (100 cases).The observation group was given paravertebral block combined with general anesthesia, while the control group was given general anesthesia.The hospitalization stay, extubation time, visual analogue scale (VAS) score and the levels of cortisol (Cor),angiotensin Ⅱ(Ang Ⅱ), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were compared between the two groups.Results The hospitalization stay ([10.12±0.11]d) and extubation time ([5.01±3.01]h) in the observation group were shorter than those in the control group ([12.21±3.15]d, [7.23±3.45]h), and the differences were statistically significant (P<0.05).The levels of Cor ([241.52±43.25]pg/ml), AngⅡ ([70.23±6.27]pg/ml) in the observation group were lower than those in the control group ([275.21±52.11], [86.45±10.11]pg/ml), and the differences were statistically significant (P<0.05).The VAS score of the observation group was (2.01±0.45) points, which was lower than that of the control group for (4.25±0.76) points, and the difference was statistically significant (P<0.05).The levels of CRP([37.15±9.21]mg/L) and TNF-α ([53.01±15.23]pg/ml) in the observation group were lower than those in the control group ([43.11±10.25]mg/L, [62.11±16.45]pg/ml), and the differences were statistically significant (P<0.05).Conclusion Paravertebral block combined with general anesthesia can improve the stress response and reduce pain in patients undergoing colorectal cancer resection.
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