GnRHa与米非司酮在腹腔镜子宫肌瘤剔除术预处理中的效果比较

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Abstract Objective To investigate the effect of gonadotropin releasing hormone analogue (GnRHa) and Mifepristone in the pretreatment of laparoscopic myomectomy.Methods A total of 50 patients who underwent laparoscopic myomectomy in our hospital from January 2016 to March 2018 were randomly selected as study subjects.The patients were divided into the experimental group and the control group according to order of single and double numbers of patients admitted to hospital, with 25 cases in each group.The control group was pretreated with GnRHa, while the experimental group was pretreated with Mifepristone, then patients in both groups were treated with laparoscopic myomectomy.The recurrence rate of uterine fibroids, estrogen receptor (ER), progesterone receptor (PR), Ki-67 protein positive rates,clinical treatment effect, perioperative indicators (intraoperative blood loss, operation time, hospitalization time) and diameter of uterine fibroids before and after medication were observed in the two groups.Results The recurrence rate of uterine fibroids in the experimental group (4.00%) was lower than that in the control group (24.00%), and the difference was statistically significant (P＜0.05).The diameter of uterine fibroids in the experimental group ([1.31±0.34]cm) after medication was smaller than that in the control group ([3.21±0.22]cm), with statistically significant difference (P＜0.05).The protein positive rates of ER (64.00%), PR (48.00%), and Ki-67 (28.00%) in the uterine fibroids of the experimental group were respectively lower than those of the control group (88.00%, 80.00%, and 60.00%), with statistically significant differences (P＜0.05).The intraoperative blood loss in the experimental group ([87.62±14.38]ml) was less than that in the control group ([102.87±15.29]ml), with statistically significant difference (P＜0.05).The operation time([56.29±5.71]min) and hospitalization time ([4.27±0.72]d) of the experimental group were shorter than those of the control group ([107.32±5.28]min, [6.21±0.11]d), with statistically significant differences (P＜0.05).The total effective rate of clinical treatment of patients in the experimental group was 96.00%, which was higher than that in the control group accounting for 72.00%, and the difference was statistically significant (P＜0.05).Conclusion Compared with Gn-RHa, the use of Mifepristone in patients with uterine fibroids is beneficial to reduce the expression levels of ER, PR and Ki-67 proteins in tumor tissues, reduce the volume of fibroids and reduce the recurrence rate of fibroids.The clinical effect of Mifepristone is higher than that of GnRHa, which is worthy of wide clinical promotion and application.

Key words： Gonadotropin releasing hormone analogue Mifepristone Laparoscopic myomectomy Uterine Diseases;Female

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	LUO Qiong
	WU Yu-qiang

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LUO Qiong,WU Yu-qiang. Effect comparison of GnRHa and Mifepristone in the pretreatment of laparoscopic myomectomy[J]. 中国当代医药, 2020, 27(3): 53-57.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I3/53

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