左氧氟沙星和莫西沙星治疗耐多药肺结核病的临床效果比较

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Abstract Objective To explore the clinical effect of Levofloxacin and Moxifloxacin in the treatment of multidrug-resistant pulmonary tuberculosis.Methods A total of 160 patients with multi-drug resistant pulmonary tuberculosis treated in our hospital from January to September 2016 were selected as research subjects, and they were divided into control group and experimental group according to the random number table method, with 80 cases in each group.The control group was mainly treated with Levofloxacin combined with Capreomycin, while the experimental group was mainly treated with Moxifloxacin combined with Capreomycin.The therapeutic effect, lesion absorption and sputum bacteria changes of the two groups were observed and compared.Results The total effective rate of treatment in the experimental group was 86.25%, which was higher than that in the control group accounting for 61.25%, and the difference was statistically significant (P＜0.05).The total absorption rate of lesions in the experimental group was 92.50%,which was higher than that in the control group accounting for 78.75%, and the difference was statistically significant(P＜0.05).The smear negative rate and sputum tuberculosis negative rate of the experimental group at 24 months of treatment were 83.75% and 86.25% respectively, which were significantly higher than those of the control group accounting for 57.50% and 58.75%, and the differences were statistically significant (P＜0.05).Conclusion Moxifloxacin combined with Capreomycin is effective in the treatment of multi-drug resistant pulmonary tuberculosis, which can promote lesion absorption and increase sputum negative rate.It is worthy of popularization and application.

Key words： Moxifloxacin Levofloxacin Multidrug-resistant pulmonary tuberculosis Clinical effect

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DANG Pei-ying. Clinical effect comparison of Levofloxacin and Moxifloxacin in the treatment of multidrug-resistant pulmonary tuberculosis[J]. 中国当代医药, 2020, 27(3): 101-103转107.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I3/101

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