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| Clinical effect of procalcitoninin guiding antibiotics in patients with severe infection |
| XIE Min-chong |
| Foshan Shunde Lunjiao Hospital, Guangdong Province, Foshan 528308, China |
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Abstract Objective To investigate the clinical effect of procalcitonin (PCT) in guiding antibiotics in patients with severe infection.Methods A total of 100 patients with severe infections from May 2017 to February 2019 treated in our hospital were selected.According to the random number table method, patients were divided into conventional treatment group and PCT guide group, 50 cases in each group.The conventional treatment was treated with conventional antibiotics treatment, and the PCT guide group was treated with PCT to guide the treatment of antibiotics.The total effective rate of the two groups was compared; the time of infection control, the average time of antibiotic use, the total length of hospital stay, the level of C-reactive protein monitoring before and after treatment, and the white blood cell count, PCT and the incidence of multi-drug resistant infection of the two groups was compared.Results The total effective rate of the PCT guide group was higher than that of the conventional treatment group, and the difference was statistically significant (P<0.05).The time to control the infection, the antibiotic use time, and the total hospital stay of the PCT guide group were shorter than those of the conventional treatment group, the differences were statistically significant (P<0.05).The level of C-reactive protein in the PCT guide group and the white blood cell count，PCT were lower than those in the conventional treatment group, and the differences were statistically significant (P<0.05).The rate of multidrug-resistant infection in the PCT guide group was 2% (1/50), which was lower than that in the conventional treatment group for 18% (9/50), and the difference was statistically significant (P<0.05).Conclusion PCT can guide the treatment of severe infections,it can achieve the desired effect, can effectively shorten the time of antibiotic use, and reduce the incidence of multi-drug resistant infection.
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