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| Clinical effect of Moxifloxacin combined with Mycobacterium vaccae in the treatment of patients with multidrug-resistant pulmonary tuberculosis and its influence on immunity |
| LI Xue-hua |
| Department of Infectious Diseases, Yangjiang Public Health Hospital, Guangdong Province, Yangjiang 529500, China |
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Abstract Objective To explore the clinical effect of Moxifloxacin combined with Mycobacterium vaccae in the treatment of patients with multidrug-resistant pulmonary tuberculosis and its influence on immune function.Methods One hundred patients with multidrug-resistant pulmonary tuberculosis admitted to our hospital from March 22, 2017 to March 22, 2018 were selected as subjects, they were divided into observation group and control group by database random grouping method, with 50 cases in each group.The observation group was treated with Moxifloxacin combined with Mycobacterium vaccae, and the control group was treated with conventional chemotherapy.The indicators of T lymphocyte 8 (CD8+), T lymphocyte 4 (CD4+), CD4+/CD8+, T lymphocyte 3 (CD3+), serum interleukin-1 (IL-1), serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), total effective rate, sputum negative conversion rate 6 months after treatment, and sputum negative conversion rate 12 months after treatment were compared between the two groups.Results In the observation group, CD4+/CD8+was (1.98±0.24), the level of CD8+was (28.75±2.41)%, the level of CD4+was(42.57±4.31)%, the level of CD3+was (69.12±4.19)%, sputum negative conversion rate of 6 months after treatment was 64.00%, sputum negative conversion rate of 12 months after treatment was 92.00% and the total effective rate was 96.00%.In the control group, CD4+/CD8+was (1.19±0.05), the level of CD8+ was (26.13±1.35)%, the level of CD4+ was(36.28±3.66)%, the level of CD3+was (62.45±3.26)%, sputum negative conversion rate of 6 months after treatment was 40.00%, sputum negative conversion rate of 12 months after treatment was 68.00%, and the total effective rate was 68.00%.The indicators of CD4+/CD8+, CD8+, CD4+, CD3+, sputum negative conversion rate of 6 months after treatment,sputum negative conversion rate of 12 months after treatment and total effective rate in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).In the observation group,the levels of IL-1, IL-6, and TNF-α were (18.53±2.39), (152.39±12.19) and (85.23±3.11) ng/ml.In the control group,the levels of IL-1, IL-6, and TNF-α were (26.37±3.18), (185.52±20.31), and (108.69±8.49) ng/ml, respectively.The levels of IL-1, IL-6 and TNF-α in observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The clinical effect of Moxifloxacin combined with Mycobacterium vaccae in the treatment of patients with multidrug-resistant pulmonary tuberculosis is remarkable, which can reduce the level of inflammatory mediators and increase the negative conversion rate of sputum and bacterium.
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