Objective To investigate the effect and potential mechanism of knocking down cyclooxygenase 2 (COX-2)on the biological characteristics of cervical cancer Hela cell line.Methods Cervical cancer Hela cells stably transfected with shRNA-COX-2 were constructed.Cell proliferation ability was detected by the CCK-8 method, cell cloning ability was detected by the clone formation method, apoptosis was detected by flow cytometry and cell migration ability was detected by Transwell.The effect of knocking down COX-2 expression on cell biological function was observed.The expression of p65 and p-p65 proteins was detected by Western Blot.Results Transfection of shRNA COX-2 induced the down-regulation of p65 and p-p65 expression, and reduced the proliferation, clonal formation and migration ability of Hela cells.Conclusion Down-regulation of COX-2 may inhibit the malignant biological characteristics of cervical cancer Hela cells by regulating the NF-κB signaling pathway, thereby inhibiting the growth of cervical cancer cells.

Objective To compare the clinical effect of hlios locking plate and Multiloc intramedullary nail in the treatment of proximal humerus fractures.Methods A total of 80 patients with proximal humerus fractures treated in our hospital from January 2016 to January 2018 were selected as the research subjects.They were divided into the locking plate group (38 cases) and the intramedullary nail group (42 cases) according to the random number table method.Patients in the locking plate group were treated with hlios locking plate, and the intramedullary nail group was treated with Multiloc intramedullary nails.The general condition, shoulder joint motion, shoulder pain and dysfunction index(SPADI) score and incidence of complications were compared between the two groups of patients.Results The length of incision and operation time of patients in the intramedullary nail group were shorter than those in the locking plate group, and the intraoperative blood loss was less than that in the locking plate group, the differences were statistically significant (P<0.05).There were no statistically significant differences in the number of intraoperative fluoroscopy and fracture healing time between the two groups (P>0.05).There were no statistically significant differences in the initial and last humeral neck shaft angle, flexion and lift, and active body external rotation between the two groups of patients(P>0.05).The angle of △neck trunk in the intramedullary nail group was lower than that in the locking plate group,and the difference was statistically significant (P<0.05).The postoperative SPADI score of patients in the intramedullary nail group was lower than that in the locking plate group, and the difference was statistically significant (P<0.05).There were no non-union, humeral head necrosis and osteoarthritis in the two groups of patients.One case of shoulder joint pain occurred in the intramedullary nail group, and two cases of incision infection occurred in the locking plate group.There was no statistically significant difference in the incidence rate of complications between the two groups (χ2=0.46,P=0.50).X-ray examination results showed that Multiloc intramedullary nails and hlios locking plate could effectively fix proximal humeral fractures.Conclusion The use of Multiloc intramedullary nails and hlios locking plate for treating proximal humeral fractures is equivalent.Multiloc intramedullary nails are superior to hlios locking plate in the selection of incision length, operation time, intraoperative blood loss and △neck trunk angle, and are worthy of clinical promotion.

Objective To investigate the short-term clinical effect of transurethral plasmakinetic resection of mid-lobal of prostate combined with postoperative Finasteride in the treatment of elderly patients with high-risk benign prostatic hyperplasia (BPH).Methods From January 2012 to January 2019, 78 dominated by mid-lobal hyperplasia of elderly patients with high-risk BPH were selected as the study subjects in our hospital.They were divided into group A (39 cases) and group B (39cases) by the random number table method.The methods used in group A and group B were respectively for transurethral resection of the prostate (TURP) and transurethral plasmakinetic resection of mid-lobal of prostate combined with postoperative Finasteride.The operation time, intraoperative blood loss, postoperative hospitalization time, postoperative urinary catheter removal time, postoperative continuous bladder flushing time, incidence of surgical complications and clinical relevant indicators(international prostate symptom score [IPSS], quality of life index [QOL]score, maximum urine flow rate [Qmax],residual urine volume [RUV]and prostate volume [PV])before and after surgery were compared in the two groups.Results The operation time, postoperative hospitalization time, postoperative urinary catheter removal time and postoperative continuous bladder flushing time of patients in the group B were shorter than those in the group A, with statistically significant differences (P<0.05).The intraoperative blood loss of patients in the group B was less than that in the group A, and the difference was statistically significant (P<0.05).The total incidence rates of intraoperative and postoperative complications of patients in the group B were lower than those in the group A, with statistically significant differences (P<0.05).There were no statistically significant differences in IPSS score, QOL score, Qmax, RUV, PV before surgery between the two groups of patients (P>0.05).The IPSS score, QOL score, RUV and PV at 3 and 6 months after surgery in the two groups were lower than those before surgery, and Qmax was higher than that before surgery, with statistically significant differences (P<0.05).The IPSS and QOL scores at 3 and 6 months after surgery in the group B were lower than those in the group A, and Qmax was higher than that in the group, with statistically significant differences (P<0.05).There were no statistically significant differences in RUV and PV between the two groups of patients at 3 months after surgery (P>0.05).The RUV and PV at 6 months after surgery in the group B were lower than those in the group A, with statistically significant differences (P<0.05).Conclusion Short-term effect of transurethral plasmakinetic resection of mid-lobal of prostate combined with postoperative Finasteride to treat elderly patients with high-risk BPH is superior to that of traditional TURP,which can reduce the risk of surgery, improve the quality of life of patients, make better the prognosis of patients.It can provide a new treatment selection strategy for the clinical treatment of elderly patients with high-risk BPH mainly with mid-lobal of prostate hyperplasia.

Cancer is the most serious disease that endangers human health and life at present, among which breast cancer is a kind of malignant tumor with the increasing rate of morbidity and mortality only second to lung cancer in recent years, and the age of onset tends to be younger.Finding a reliable diagnostic index for breast cancer has become a hot spot in clinical research.Because breast cancer is caused by a small number of self-renewing tumor stem cells,these stem cells may also play a role in tumor recurrence.Thus, genes that regulate cancer stem cells have important implications for cancer control.The Zeste enhancer homologue 2 (EZH2) gene is expressed in increased breast cancer development and plays a role in the increase in the number of breast stem cells.The specific role of EZH2 and the relationship between its miRNA and breast cancer were analyzed

This paper explains the concept of acceptance of disability, assessment tools, and the factors affecting the acceptance of disability are summarized and analyzed.It mainly includes demographic characteristics, disease characteristics, patients′ understanding of the disease, personal factors (personality traits, coping styles, daily functional activities, etc.) and psychosocial factors (psychology, positive and negative emotional experience, family and social support,etc.).It is proposed that longitudinal research should be carried out in future studies to deeply explore the factors affecting acceptance of disability, and on this basis, targeted intervention measures should be formulated to help patients accept themselves, establish the perseverance and determination to face the disease positively, and promote the recovery of patients.

Objective To establish a high performance liquid chromatography method for the determination of paeoniflorin in Raidix Paeoniae Alba in Chanhou Zuoyue Paste.Methods High performance liquid chromatography was used to determine the content of paeoniflorin in Chanhou Zuoyue Paste, the chromatographic columns were Venusil MP C18(250 mm×4.6 mm, 5 μm, 100A) or Diamonsil C18 (250 mm×4.6 mm, 5 μm).The mobile phase was acetonitrile-water(14∶86), the detection wavelength was 230 nm, and the flow rate was 1.0 ml/min.Results The detection concentration of paeoniflorin in the range of 1.93-38.60 μg/μl showed a good linear relationship with the peak area integral value (r=0.9999), the average recovery was 99.96%, RSD was 0.81% (n=9).Conclusion This method is simple, accurate, and reproducible, it can be used for the quality control of Chanhou Zuoyue Paste.

Objective To establish an ultra-high performance liquid chromatography-andem mass spectrometry (UPLCMS/MS) method for the content determination of rutin in Xiakucao Tablets.Methods UPLC-MS/MS method was used and the chromatographic column was ACQUITY UPLC RBEH C18 column (2.1 mm×100 mm, 1.7 μm), the mobile phase was methanol-aqueous solution(47：52).The mass-charge ratio(m/z)of 300.1 ion was determined by using an electrospray ionization (ESI) in positive ionization mode.Results The established method was able to rapidly detect the rutin content in Xiakucao Tablets with a good linear relationship (r=0.9993) within the concentration range of 10.78-172.48 ng/ml,and the average recovery rate was 99.44%.The method had good repeatability and precision.Conclusion The method has strong specificity, rapid sensitivity and is suitable for the content determination of rutin in Xiabancao Tablets.

Objective To explore the effect of Metformin combined with Irbesartan in the treatment of diabetes with hyperuricemia.Methods A tatal of 80 patients with diabetes and hyperuricemia received in our hospital from January 2017 to August 2019 were selected as the research object and divided into control group and experimental group by the random number table method, each with 40 cases.The control group accepted Metformin on the basis of conventional treatment, and the experimental group accepted Irbesartan in combination with the control group.The blood glucose index, insulin resistance index, body mass index changes, and serum uric acid levels were compared between the two groups.Results After treatment, the fasting blood glucose, 2h postprandial blood glucose, and glycated hemoglobin levels in the experimental group were lower than those in the control group (P<0.05);after treatment, the insulin resistance index, body mass index, and serum uric acid levels in the experimental group were lower than those in the control group, the differences were statistically significant (P<0.05).Conclusion Metformin combined with Irbesartan can reduce the body mass index of patients with diabetes and hyperuricemia, correct insulin resistance, regulate blood glucose metabolism, and reduce serum uric acid levels.

Objective To investigate the value of severe ultrasound monitoring of excursion of diaphragm in prediction of weaning ability in patients with mechanical ventilation in intensive care unit (ICU).Methods The clinical data of 100 patients with respiratory failure who admitted to our hospital from May 2018 to December 2019 were retrospectively analyzed, and they were divided into successful withdrawal group (77 cases) and failed withdrawal group (23 cases)according to withdrawal situation.The excursion of diaphragm of patients was measured by ultrasound instruments, and the ROC curve was used to evaluate the predictive value of excursion of diaphragm in weaning ability of patients with mechanical ventilation in ICU.Results The 0.1 s airway occlusion pressure (P0.1) and rapid-shallow-breathing index(RSBI) in failed withdrawal group group were higher than those in successful withdrawal group, and the left excursion of diaphragm, right excursion of diaphragm and mean excursion of diaphragm in failed withdrawal group group were lower than those in successful withdrawal group (P<0.05);After analysis of the ROC curve, the area under the ROC curve (AUC) obtained by P0.1 was 0.831, when the optimal cutoff value was 2.50 cmH2O, the sensitivity was 0.739 and the specificity was 0.299.The AUC obtained by RSBI was 0.839, when the optimal cutoff value was 45.40, the sensitivity was 0.783 and the specificity was 0.208.The AUC obtained by left excursion of diaphragm was 0.904, when the optimal cutoff value was 0.77 cm, the sensitivity was 0.870 and the specificity was 0.234.The AUC obtained by right excursion of diaphragm was 0.901, when the optimal cutoff value was 1.12 cm, the sensitivity was 0.826 and the specificity was 0.208.The AUC obtained by mean excursion of diaphragm was 0.909,when the optimal cutoff value was 1.00 cm,the sensitivity was 0.913 and the specificity was 0.494.Conclusion Severe ultrasound monitoring of excursion of diaphragm has higher application value in prediction of weaning ability in patients with mechanical ventilation in ICU.

Objective To investigate the impact of Helicobacter pylori eradication therapy (Hp) and low dose Aspirin on upper digestive tract mucosal injury among patients with coronary heart disease, and to provide evidence for making clinical decision.Methods A total of 105 patients combined with coronary heart disease and Hp infection were selected from January 2014 to December 2015 in our hospital.The patients were divided into Hp group (n=52) and control group (n=53) by using random number table method.Hp group received anti-Hp treatment according to standard protocol, and control group received routine treatment.The patients were followed up for 6 months, the occurrence of gastrointestinal symptoms and upper gastrointestinal mucosal injury were observe between two groups.Results The occurrence of gastrointestinal symptoms in Hp group and control group was 19.2% and 49.1% respectively;the occurrence of upper gastrointestinal mucosal injury in Hp group and control group was 7.7% and 22.6% respectively.The total occurrence rates of gastrointestinal symptoms and upper gastrointestinal mucosal injury were lower in Hp group than those in the control group, the differences were statistically significant (P<0.05).Conclusion To reduce the risk of gastrointestinal symptoms and upper gastrointestinal mucosal injury, patients combined with coronary atherosclerosis and Hp infectious should eradicate Hp infections.

Objective To explore the application effect of pre-hospital emergency safety checklist for patients with chest pain.Methods From January 2019 to January 2020, 60 pre-hospital emergency patients with chest pain admitted to the Department of Emergency of Shangrao People′s Hospital, Jiangxi Province were selected as the research objects.The historical control method was selected for grouping, a total of 30 patients with chest pain from January to August 2019 were selected as the control group, 30 patients with chest pain from September 2019 to January 2020 were set as the observation group.The observation group used pre-hospital emergency safety checklist for chest pain patients(compiled by the research group) to optimize the first aid process, while the control group adopted conventional first aid method.Both groups of patients were given first aid according to the pre-hospital emergency nursing measures formulated by our hospital.The success rate of rescue, satisfaction of patients' family members and emergency treatment time were compared between the two groups.Results In the observation group, the success rate of continuous rescue and the total satisfaction of the patients′ family members were higher than those of the control group, and the emergency treatment time was shorter than that of the control group, with statistically significant differences (P<0.05).Conclusion The use of pre-hospital safety checklist can improve the success rate of continuing rescue, shorten the time of pre-hospital first aid, improve patient satisfaction, and is suitable for pre-hospital first aid.

Objective To explore the effect of different application timings of continuous renal replacement therapy(CRRT) in patients with sepsis and acute kidney injury.Methods A retrospective analysis was conducted on 84 patients receved CRRT with sepsis and AKI stage 2/3 admitted to the Department of Intensive Care Unit, People′s Hospital of Xinhui District in Jiangmen City, Guangdong Province from April 2018 to August 2019.According to the AKI staging in 2012 KDIGO guidelines, patients with sepsis and AKI stage 2 for CRRT were selected as the early group (41 cases), and patients with sepsis and AKI stage 3 for CRRT were selected as the late group (43 cases).The levels of inflammatory mediators (interleukin-10 [IL-10], interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α]and procalcitonin[PCT]) before and after CRRT for 72h were compared between the two groups.The length of hospital stay, total length of hospital stay, fatality rate at 90 days and fatality rate in hospital were compared between the two groups.Results The PCT, IL-6, IL-10 and TNF-α levels after CRRT for 72h in the early group were lower than those in the late group,and the differences were statistically significant (P<0.05).The length of ICU stay and total length of hospital stay in the early group were shorter than those in the late group, and the differences were statistically significant (P<0.05).The fatality rate at 90 days and fatality rate in hospital in the early group were lower than those in the late group, with statistically significant differences (P<0.05).Conclusion The application effect of different application timings of CRRT in patients with sepsis and acute kidney injury are varies greatly.Compared with sepsis and AKI stage 3 for CRRT, sepsis and AKI stage 2 for CRRT could effectively reduce inflammatory response, shorten the length of ICU stay and total length of hospital stay, and reduce the fatality rate at 90 days and fatality rate.

Objective To explore the clinical effect of uterine fibroid embolization (UFE) via radial artery approach in the treatment of uterine fibroids.Methods A total of 70 cases of hysteromyoma admitted to our hospital from February 2018 to November 2019 were selected as subjects, and they were divided into observation group and control group according to random number table method, with 35 cases in each group.The patients in the control group were treated with UFE via femoral artery approach, and the patients in the observation group were treated with UFE via radial artery approach.The puncture time, total postoperative complication rate, and pain scores of 30 minutes, 6 hours and 24 hours after operation were compared between the two groups.Results The puncture time in the observation group was(7.57±2.80) min, which was shorter than that in the control group of (13.11±4.07) min, with statistically significant difference (P<0.05).The total incidence of postoperative complications in the observation group was 8.57%, which was lower than that in the control group (28.57%), and the difference was statistically significant (P<0.05).There was no significant difference in the pain score 30 min after operation of the two groups (P>0.05).The pain scores of the two groups at 6 h and 24 h after operation were lower than 30 min after operation, and the differences were statistically significant (P<0.05).At 6 and 24 h after operation, the pain scores of patients in the observation group were lower than those of the control group, with statistically significant differences (P<0.05).Conclusion Compared with conventional transfemoral approach UFE, UFE via radial artery approach for uterine fibroids can further shorten the puncture time,reduce the incidence of postoperative complications, and relieve patients′ pain symptoms

Objective To evaluate the diagnostic value of point-of-care testing (POCT) in the risk assessment of patients with emergency chest pain.Methods From October 2016 to October 2018, 180 patients with emergency chest pain treated in emergency department of Beijing Nuclear Industry Hospital were selected as the research objects.They were divided into observation group (n=100) and control group (n=80) according to its detection method.The observation group used POCT technology to detect the relevant indicators, and the control group used the conventional laboratory method to detect.The emergency detention time, specimen detection time and clinical treatment time of detection reports were compared between the two groups.The emergency retention time, specimen detection time, detection report clinical disposal time of the two groups were compared, and the accuracy of POCT detection, the success rate of rescue,the incidence of cardiovascular events, and the accuracy of reexamination were compared between two groups.Results The emergency retention time, specimen detection time, clinical treatment time and hospitalization time of the observation group were all shorter than those of the control group, the differences were statistically significant (P<0.05).The sensitivity, specificity and accuracy of the two methods were not statistically significant, the differences were not statistically significant (P>0.05).The success rate of rescue and the accuracy of reexamination in the observation group were higher than those in the control group, while the incidence of cardiovascular events was lower than that in the control group, and the differences were statistically significant (P<0.05).Conclusion The application of POCT in patients with emergency chest pain is fast and reliable.It can accurately assess the dangerous level, improve the success rate of rescue and the accuracy of retest, reduce cardiovascular events.

Objective To explore the effect of continuous cold compress and intermittent cold compress on the extraction of impacted mandibular wisdom teeth.Methods From November 2018 to July 2019, 96 patients with impacted mandibular wisdom teeth were selected and divided into continuous group and intermittent group, each had 48 cases.All patients were kept in hospital for 24 h after tooth extraction and received routine nursing.On this basis, the continuous group accepted 24 h continuous cold compress, and the intermittent group accepted 24 h intermittent nursing.The degree of facial swelling, the degree of pain and the local skin temperature were measured at 6, 12 and 24 hours after operation.Results There was no statistically significant difference in the degree of facial swelling between the two groups at 6 hours after surgery (P>0.05);the degree of facial swelling at the 12 and 24 hours after surgery in the continuous group were lower than those in the intermittent group (P<0.05).The pain levels in the continuous group were lower than those in the intermittent group at 6, 12, and 24 hours after operation, and the differences were statistically significant (P<0.05).The skin temperature of the continuous group were lower than those of the intermittent group at 6,12, and 24 hours after operation, and the differences were statistically significant (P<0.05).Conclusion Compared with intermittent cold compress, continuous cold compress can improve the facial skin temperature and swelling degree of patients with impacted wisdom teeth after extraction, and reduce the pain degree of patients, which is worthy of clinical application.

Objective To investigate the effect of Dapagliflozin in the treatment of acute myocardial infarction with stress hyperglycemia.Methods From January 2017 to December 2019, 66 patients with acute myocardial infarction and stress hyperglycemia who were hospitalized in the department of internal medicine cardiovascular of our hospital were selected as the research objects.They were divided into group D (30 cases) and group I (36 cases) according to the random number table method.Patients in group D were given Dapagliflozin, and group I was given Insulin.The blood glucose, cardiac function and other indicators were compared between the two groups.Results Fasting blood glucose(FBG) and blood glucose (2h PBG) at 1 and 6 weeks after treatment were both lower in the two groups than those before treatment, with statistically significant differences (P<0.05).After 1 week of treatment, the levels of FBG and 2h PBG in group D were lower than those in group I, with statistically significant differences (P<0.05).After 6 weeks of treatment, the left ventricular ejection fraction (LVEF) of group D was higher than that of group I, and the body mass index (BMI) was lower than that of group I, with statistically significant differences (P<0.05).The incidence of hypoglycemia between the two groups was not statistically significant (P>0.05).Conclusion Dapagliflozin is effective in treating patients with acute myocardial infarction combined with stress hyperglycemia, and can effectively improve cardiac function with good safety.

Objective To investigate the effect of Dapagliflozin combined with Liraglutide in the treatment of type 2 diabetes mellitus.Methods A total of 80 cases with type 2 diabetes mellitus from January 2017 to October 2018 in our hospital were selected as the research objects, and were divided into the observation group (40 cases) and the control group (40 cases) according to the random number table method.The control group was treated with Liraglutide, the observation group was treated with Dapagliflozin before breakfast on the basis of the control group.The blood glucose metabolic indexes (such as abdominal blood glucose, blood glucose 2 hours after meal, HbA1c and HOMA-IR changes), the metabolic indexes of blood lipid (such as total cholesterol [TC], triglyceride [TG], low density lipoprotein[LDL-C]and high density lipoprotein [HDL-C]), the changes of body mass index (BMI) in the two groups before and after intervention were compared.The complications of the two groups were analyzed after one year follow-up.Results The levels of fasting blood glucose, 2-hour postprandial blood glucose, HbA1c and HOMA-IR in the blood glucose metabolic indexes in the observation group after intervention were lower than those in the control group, the differences were statistically significant (P＜0.05).The levels of TC, TG and LDL-C in blood lipid metabolic indexes in the observation group after intervention were lower than those in the control group, the levels of HDL-C in the observation group after intervention was higher than control group, the differences were statistically significant (P＜0.05).After intervention, the BMI in the observation group was lower than before intervention and in the control group after intervention,the differences were statistically significant (P＜0.05).During the follow-up period of one year, the incidence of diabetic foot, retinopathy, peripheral neuropathy and diabetic nephropathy in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The combination of Liraglutide and Dapagliflozin for type 2 diabetes can better regulate blood sugar, lipid metabolism and body constitution, and reduce or delay the incidence of complications.

Objective To investigate the application effect of combination of Saglitine and Insulin in the treatment of type 2 diabetes mellitus.Methods The clinical data of 120 patients with type 2 diabetes mellitus admitted to our hospital from January 2017 to January 2019 were analyzed retrospectively, The patients were divided into the reference group (n=60) and the study group (n=60) according to different medication methods.The control group was treated with Insulin, while the study group was treated with Insulin combined with Saxagliptin.The blood glucose control, treatment effect and blood glucose reaching standard time were compared between the two groups.Results The levels of HbA1c,FBG and 2h PG in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05).The total effective rate of the study group was 96.67%, which was higher than 83.33% of the control group, the difference was statistically significant (P＜0.05).The dosage of Insulin in the study group was less than that in the control group, and the time of blood glucose reaching the standard in the study group was shorter than that in the control group, the differences were statistically significant (P＜0.05).After treatment, the body mass index of the study group was lower than that of the control group, and the mean amplitude of glycemic excursion (MAGE), number of glycemic excursion (NGE), hyperglycemia of area under curve (AUC) and mean of daily differences (MODD) in the study group were lower than those of the control group, the differences were statistically significant (P＜0.05).Conclusion The combination of Saxagliptin and Insulin can effectively control the blood glucose level of patients with type 2 diabetes mellitus, with significant clinical effect, and can reduce the dosage of insulin, shorten the time of blood glucose reaching the standard, with significant clinical value.

Objective To investigate the influence of Lilarutide combined with Metformin on bodyweight, fat distribution and β cell function in overweight/obese subjects with early type 2 diabetes mellitus (T2DM).Methods A total of 80 newly diagnosed overweight/obese T2DM patients treated in our hospital from June 2018 to June 2019 were selected as the research objects, and they were divided into the study group and the control group by a random number table method, 40 cases in each group.The control group was treated with Metformin, and the study group was treated with Liraglutide on the basis of the control group.The treatment lasted 24 weeks.Changes in bodyweight, body mass index(BMI), fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), visceral fat area (VFA), subcutaneous fat area (SFA), homeostasis model assessment-β cell (HOMA-β) and homeostasis model assessment-insulin resistance(HOMA-IR) were compared between the two groups before and after treatment.Results After treatment, the bodyweight, BMI, FBG, HbA1c, HOMA-IR, VFA and SFA of the two groups were lower than those before treatment, and HOMA-β of the two groups was higher than that before treatment, with statistically significant differences (P＜0.05).After treatment, the bodyweight, BMI, FBG, HbA1c, HOMA-IR, VFA and SFA of the patients in the study group were lower than those in the control group, and HOMA-β in the study group was higher than that in the control group, with statistically significant differences (P＜0.05).There was no significant difference in the ratio of VFA to SFA (VSR) between the two groups before and after treatment (P＞0.05).Conclusion Liraglutide has good effects on reducing glucose,weight loss, improving fat distribution and β cell function in overweight/obese subjects with early T2DM.

Objective To investigate the clinical effect of human adipose tissue and synovial mesenchymal stem cells in the treatment of knee osteoarthritis.Methods A total of 30 patients admitted in our hospital from January to November in 2018 were selected as the research objects.They were divided into adipose-derived mesenchymal stem cells (ADMSCs) group (10 cases), synovial-derived mesenchymal stem cells (SDMSCs) group (10 cases), and combined treatment group (10 cases) according to different treatment methods.Adipose-derived mesenchymal stem cells were injected into the articular cavity.The SDMSCs group was injected with autologous synovial mesenchymal stem cells.The combination group used the above two types of mesenchymal stem cells combined therapy.The visual pain scale (VAS) score,knee joint score, osteoarthritis index (WOMAC) score, treatment effect, and postoperative complications were compared between the three groups of patients.Results There were no significant differences in the VAS scores and knee scores of the three groups before treatment (P＞0.05);the VAS scores of the three groups after treatment were lower than before treatment, and the knee scores were higher than before treatment, the differences were statistically significant (P＜0.05);after treatment, the VAS score of the combined group was lower than that of the ADMSCs group and SDMSCs group,and the knee score was higher than that of the ADMSCs group and SDMSCs group, the differences were statistically significant (P＜0.05);after treatment, there were no significant differences in the scores of VAS and knee joints in ADMSCs group and SDMSCs group (P＞0.05).There were no statistically significant differences in the WOMAC score before injection among the three groups (P＞0.05);the WOMAC scores at 6 and 12 months after injection in the three groups were lower than before injection, and the differences were statistically significant (P＜0.05);the combination 6 and 12 months after injection, the WOMAC scores were lower than that in the ADMSCs group and SDMSCs group, the differences were statistically significant (P＜0.05) , but there was no significant difference in the WOMAC scores between the ADMSCs group and the SDMSCs group after treatment (P＞0.05).The total incidence of complications in the combined group was lower than that in the ADMSCs group and the SDMSCs group, and the differences were statistically significant (P＜0.05).Compared with the total incidence of complications in the ADMSCs group and the SDMSCs group, the difference was not statistically significant (P>0.05).The rate of excellence in the combined group was lower than that in the ADMSCs group and the SDMSCs group,and the differences were statistically significant (P＜0.05).Compared with the rate of excellence in the ADMSCs group and the SDMSCs group, the difference was not statistically significant (P＞0.05).Conclusion The use of autologous ADMSCs combined with SDMSCs can promote the improvement of knee function, relieve pain and improve the efficacy of knee osteoarthritis patients.

Objective To investigate the application of different intramedullary nail systems in senile femoral intertrochanteric fracture.Methods A tatal of 80 patients with femoral intertrochanteric fracture who admitted in the hospital from February 2017 to February 2019 were divided into the proximal anti-rotation intramedullary nail (PFNA)group and the proximal femoral intramedullary nail (PFN) group according to the random number table method, with 40 cases in each group.PFEA group accepted proximal femoral nail anti-rotation (PFNA) surgery, and PFE group accepted proximal femoral nail (PFN) surgery.The surgical indexes, hip joint function, quality of life and complications were compared between two groups.Results The operation time of PFEA group was shorter than that of PFE group, and the intraoperative bleeding volume in PFEA group was less than that in PFE group (P<0.05).The excellent rate of hip joint recovery in PFEA group was higher than that in PFE group (P<0.05).After surgery, the scores of Short Form 36-item Health Survey (SF-36) scale in PFEA group were higher than those in PFE group (P<0.05).The total incidence of postoperative complications in PFEA group was lower than that in PFE group (P<0.05).Conclusion PFNA surgery is effective in treating femoral intertrochanteric fractures, with less trauma and fewer complications, which is conducive to early postoperative rehabilitation.

Objective To investigate the effect of hollow nail internal fixation via tarsal sinus on AOFAS score and complications of calcaneal fracture.Methods A total of 80 patients with calcaneal fractures admitted in our hospital from February 2018 to March 2019 were selected as the research object, and were divided into two groups according to the random number table method, 40 cases in each group.The control group was internally fixed with lateral enlarged incision steel plate, and the observation group was internally fixed with hollow nails of tarsal sinus approach.The postoperative foot function, imaging indexes at 3 months after operation, AOFAS score and complications during the 1 year follow-up were compared between the two groups.Results Three months after operation, the height of calcaneal tubercle and Bohler angle of observation group were larger than that of control group, and the widths of calcaneus were smaller than control group, the differences were statistically significant (P<0.05);3 months after operation and 1 year after operation, the AOFAS scores of the observation group were higher than that of the control group, and the differences were statistically significant (P<0.05);1 year after surgery, the total proportion of incision infection, skin necrosis,osteomyelitis, and sural nerve injury in the observation group was lower than that in the control group, the good rate of foot function evaluation in the observation group was higher than that in the control group, and the differences were statistically significant (P<0.05).Conclusion The tarsal sinus approach with hollow screw internal fixation can effectively promote the anatomical reduction of calcaneus in patients with calcaneal fractures, and promote the recovery of postoperative foot function with less complications and high efficacy.

Objective To investigate the clinical effect of posterior minimally invasive percutaneous pedicle screw rod system internal fixation in the treatment of thoracolumbar fractures.Methods A total of 60 patients with thoracolumbar fractures admitted in our hospital from January 2017 to June 2018 were selected and divided into observation group and control group according to the random number table method, 30 cases in each group.The control group received posterior incision vertebral arch screw system internal fixation, and the observation group received posterior minimally invasive percutaneous pedicle screw system internal fixation.The operation duration, blood loss and postoperative complications of the two groups were observed and analyzed.Results The effective rate of the observation group was higher than that of the control group, the length of operation was shorter than that of the control group, the intraoperative blood loss was less than that of the control group, and the incidence of postoperative complications was lower than that of the control group, all with statistically significant differences(P<0.05).Conclusion Compared with the internal fixation of posterior pedicle screw and rod system, the posterior percutaneous minimally invasive pedicle screw and rod system for the treatment of thoracolumbar fractures has a significant clinical effect and is worthy of popularization and application in clinical treatment.

Objective To explore the application of vascularized bone transplantation in the treatment of limb bone tumors.Methods From January 2015 to December 2018, 100 patients with limb bone tumor were selected as the research subjects, which were divided into study group (50 cases) and control group (50 cases) according to the method of random drawing.In the control group, there was no vascularized bone graft after segmental tumor resection, and in the study group, the vascularized bone graft was used bone healing time, pre-and post-treatment visual simulation score(vas) score, clinical treatment effect, and treatment complications were compared between the two groups.Results The times of bone healing in the study group were shorter than that in the control group (P<0.05).There was no significant difference in VAS scores between the two groups (P>0.05).The scores of VAS in the study group were lower than those in the control group (P<0.05).The excellent and good rate of clinical treatment in the study group was higher than that in the control group (P<0.05).The total incidence of complications in the study group was lower than that in the control group (P<0.05).Conclusion Vascular bone transplantation can effectively relieve the pain of patients with bone tumors in the extremities, reduce the time of postoperative bone healing, and have a low incidence of postoperative complications, which can achieve ideal clinical efficacy.

Objective To explore the diagnostic value of video assisted mediastinoscopy (VAM) in mediastinal mass and lung cancer.Methods A total of 40 patients with high suspicion of mediastinal mass and 40 patients with high suspicion of lung cancer who were admitted to our hospital between February 2016 and June 2019 were enrolled in the study.All subjects underwent VAM and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).Taking the pathological results of paraffin sections as the golden standard, the accuracy rates, sensitivities and specificities of the two surgeries in the diagnosis of mediastinal mass and lung cancer were calculated, the incidence rate of complications was statistically analyzed.Results The sensitivity and accuracy of VAM in the diagnosis of mediastinal mass and lung cancer were higher than those of EBUS-TBNA, the differences were statistically significant (P<0.05).There were no significant difference in the incidence rates of hoarseness, pneumothorax, infection or massive hemorrhage between the two examination methods (P>0.05).Conclusion The sensitivity and accuracy of VAM are higher than those of EBUS-TBNA in the diagnosis of mediastinal mass and lung cancer, without increasing the risk of complications, and it is worthy of clinical promotion.

Objective To explore the effect of Huai′er Granules in radiochemotherapy for patients with nasopharyngeal carcinoma.Methods A total of 60 patients with nasopharyngeal carcinoma who underwent concurrent radiotherapy and chemotherapy from January 2014 to January 2016 were selected as the research objects.The selected patients were divided into the control group and the observation group by simple randomization, 40 cases in each group.The control group was treated with concurrent chemoradiotherapy, and the observation group was treated with concurrent chemoradiotherapy combined with Huai′er Granules.One month after the treatment was completed, the changes in T cell expression, clinical efficacy, and quality of life of patients of the two groups before and after treatment were analyzed.Results The total effective rate of clinical treatment of patients between the two groups was not statistically significant (P>0.05).After treatment, the expression levels of CD3+, CD4+, CD4+/CD8+ cells in two groups were higher than before treatment, and the expression levels of CD3+, CD4+, CD4+/CD8+ cells in the observation group were higher than those in control group, the differences were statistically significant (P<0.05).After treatment, the expression level of CD8+ cells in two groups were lower than those before treatment, and the expression level of CD8 + cells in the observation group was lower than that in control group (P<0.05).After radiochemotherapy, the physical function score of the observation group was higher than that in the control group, and the meanwhile, the fatigue, nausea/vomiting and pain scores in observation group were lower than those in control group, the differences were statistically significant (P<0.05).Conclusion Huai′er Granule can effectively improve the immune function of nasopharyngeal carcinoma after radiotherapy and chemotherapy at the same time, and can also improve the quality of life of patients.It is worthy of further clinical research.

Objective To explore the clinical significance of EBV-DNA quantitative detection in patients with recurrence and metastasis of nasopharyngeal carcinoma after radiotherapy.Methods A total of 60 patients with nasopharyngeal carci noma treated in Ji′an Central People′s Hospital from January to November 2019 were selected as the research objects.According to the curative effect after radiotherapy, they were divided into three groups：continuous remission group (38 cases), local recurrence group (13 cases) and distant metastasis group (9 cases).EBV-DNA gene copies in whole blood were detected by PCR in all patients.The positive detection rate of EBV-DNA and the copy number of EBV-DNA were compared among the three groups, and the changes of EBV-DNA copies before and after the second treatment were further compared.Results The positive detection rate of EBV-DNA and the copy number of EBV-DNA in the local recurrence group and the distant metastasis group were higher than those in the continuous remission group, and the differences were statistically significant (P＜0.05);the positive detection rate of EBV-DNA and the copy number of EBV-DNA in the local recurrence group and the distant metastasis group were not significantly differents(P＞0.05);the copy number of EBV-DNA in the local recurrence group and the distant metastasis group after treatment were lower than those before treatment, the difference was statistically significant (P＜0.05).There were no significant differences in the number of EBV-DNA copies between local recurrence group and distant metastasis group before and after treatment (P＞0.05).Conclusion There are significant differences in the results of quantitative detection of plasma EBV-DNA in patients with different radiotherapy prognosis.Quantitative detection of plasma EBV-DNA can be used as a reliable tumor marker to monitor the recurrence and metastasis of nasopharyngeal carcinoma after radiotherapy.

Objective To investigate the effect of lower ligation of inferior mesenteric artery in patients undergoing laparoscopic radical resection of rectal cancer.Methods The clinical data of 85 patients undergoing laparoscopic radical resection of rectal cancer treated in our hospital from January 2015 to December 2016 were retrospectively analyzed.Divided into two groups according to the different mesenteric ligation sites during operation, 45 patients with low ligation of inferior mesenteric artery during operation were regarded as low group, and 40 patients with high ligation of inferior mesenteric artery during operation were regarded as high group.The number of intraoperative lymph node dissection, surgical operation index and recovery index, and postoperative complications were compared between the two groups of patients;follow-up to December 31, 2019 and the 3-year cumulative survival rate of the two groups of patients were compared.Results There were no significant differences in surgical time, intraoperative blood loss, length of hospital stay, total number of lymph node dissections, number of lymph node dissections at the third station, lymph node metastasis rate at the third station and 3-year cumulative survival rate between the two groups of patients (P>0.05).The exhaust time of the lower group was shorter than that of the high group, and the total incidence of postoperative complications was 4.44%, lower than that of the high group, accounting for 25.00%, and the differences were statistically significant (P<0.05).Conclusion The application of lower ligation of inferior mesenteric artery in laparoscopic radical resection of rectal cancer has the same survival rate and lymph node dissection as the high ligation of inferior mesenteric artery.However, lower ligation of inferior mesenteric artery can reduce the incidence of postoperative anastomotic leakage, which is highly safe and worthwhile application.

Objective To explore the clinical effect of radiofrequency ablation combined with targeted therapy under CT on renal cancer.Methods A total of 79 patients with renal cancer treated in Benxi Central Hospital from February 2018 to April 2019 were selected as the research objects, and randomly divided into the control group (n=39) and the observation group (n=40) according to the double-blind method.The control group was treated with targeted therapy,and the observation group was treated with radiofrequency ablation + targeted therapy under CT.The clinical efficacy and tumor marker levels of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).There were no significant differences between the two groups in the levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125) before treatment (P>0.05);the levels of CEA and CA125 after treatment in the two groups were lower than those before treatment, and the levels of CEA and CA125 in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusions Radiofrequency ablation combined with targeted therapy for renal cancer using CT has significant curative effect and can effectively reduce tumor marker levels.

Objective To explore the effect of Pemetrexed Disodium and Docetaxel in combination with Nedaplatin in the treatment of advanced lung adenocarcinoma.Methods A total of 80 patients with advanced lung adenocarcinoma who were treated to our hospital from April 2017 to March 2019 were selected as the research objects.According to the random number table method, the research objects were divided into control group and study group, 40 cases in each group.The control group was treated with Docetaxel plus Nedaplatin.The study group was treated with Pemetrexed Disodium in combination with Nedaplatin.The treatment effect, T lymphocytes (CD3+、CD4+、CD8+、CD4+/CD8+) and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment between the two groups of patients was not statistically significant (P>0.05).After 4 cycles of chemotherapy, the CD3+,CD4+, CD4+/CD8+ of the two groups of patients were higher than those before chemotherapy, and CD8+ was lower than that before chemotherapy, and the CD3+, CD4+, CD4+/CD8+ of the study group were higher than those in the control group, and CD8+was lower than that in the control group, the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group, the difference was statistically significant (P<0.05).Conclusion The clinical effect of Pemetrexed Disodium and Docetaxel in combination with Nedaplatin in the treatment of advanced lung adenocarcinoma is comparable, but Pemetrexed Disodium combined with Nedaplatin can enhance the immune function of patients, less adverse reactions, worthy of clinical application.

Objective To investigate the application effect of positive psychological nursing intervention in venous transfusion in infants.Methods A total of 200 children with venous transfusion who were admitted to our hospital from January to November 2019 were selected.All cases were divided into control group and observation group according to the principle of randomized trial, 100 cases in each group.The control group was given routine nursing, and observation group was given positive psychological nursing intervention based on routine nursing.The fear，pain degree of venous transfusion, and satisfaction of family members were compared between the two groups.Results The degree of fear in observation group after intervention was lighter than that in control group, and the difference was statistically significant(P<0.05).The scores of children′s face, legs, activity, cry, consolability behavioral tool (FLACC) and total score in observation group after intervention were lower than those in control group, and the differences were statistically significant (P<0.05).The total satisfaction of family members in observation group was higher than that in control group, and the difference was statistically significant (P<0.05).Conclusion Positive psychological nursing intervention can effectively reduce the fear of infants with venous transfusion, and decrease the degree of pain.

Objective To explore the effect of different time limits of active period on the maternal and infant outcomes under the new labor management model.Methods Retrospective analysis of the clinical data of 360 full-term primiparas treated to the department of obstetrics and gynecology in our hospital from July 2018 to July 2019.Grouped according to the different active periods, 180 pregnant women with active period <4 h were included in the control group,and another 180 pregnant women with active period ≥4 h were included in the observation group.The perioperative indicators, the Apgar scores at 1 minute and 5 minutes after delivery, the pregnancy outcomes and complications were compared between the two groups.Results The maternal postpartum hemorrhage volume in the observation group was lower than that in the control group, and the total duration of labor was longer than that in the control group, the differences were statistically significant (P＜0.05).There were no significant differences in the Apgar score of newborns between the two groups 5 minutes after delivery and 1 minute after delivery (P＞0.05).The rate of maternal conversion tocesarean section in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of amniotic fluid fecal infection and neonatal asphyxia between the two groups (P＞0.05).Conclusion The new labor management mode takes the active period ＞4 h as the treatment time limit to allow the pregnant women to have sufficient time for trial delivery, reduce the cesarean delivery rate, improve the perioperative index, and benefit the prognosis of the pregnant women.It is recommended of clinical application.

Objective To explore the clinical effect of Fuyanping Capsules combined with Metronidazole Suppository on vaginal microecology in patients with vaginitis.Methods From January to December 2019, 400 patients with vaginitis received treatment in the Community Health Service Center of Qingxi Town were randomly divided into the observation group (Fuyanping Capsules with Metronidazole Suppository) and the control group (Metronidazole Suppository, with 200 cases in each group.The vaginal microecological indexes and therapeutic effect of the two groups were compared.Results After treatment, the pH value, bacterial density and diversity of vagina in the observation group were better than those in the control group, the differences were statistically significant (P<0.05).The number of lactobacilli in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05).The total effective rate in the observation group (95.50%) was higher than that in the control group (82.50%), the difference was statistically significant (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions of patients between the two groups (P>0.05).After 3 months of follow-up, the relapse rate in the observation group (5.24%) was lower than that in the control group (27.88%), the difference was statistically significant (P<0.05).Conclusion Fuyanping Capsules combined with Metronidazole Suppository for vaginitis can improve the internal environment of the vagina, improve the curative effect, reduce adverse reactions, and prevent disease recurrence.

Objective To explore the relationship between delivery mode and pregnancy outcome of elderly pregnant women.Methods The clinical data of 120 elderly pregnant women who delivered in our hospital from August 2017 to June 2019 were analyzed retrospectively.According to the different modes of delivery, they were divided into vaginal delivery group and cesarean delivery group, 60 cases in each group.The pain degree, psychological state, postpartum hemorrhage, lying in time after delivery and Apgar score of newborn were compared between two groups.Results The scores of visual analogue scale (VAS), self-rating depression scale (SDS) and self-rating anxiety scale (SAS) in vaginal delivery group were (8.37±1.42), (37.28±4.31), (40.45±4.42) points, which were higher than those in cesarean delivery group for (3.75±0.42), (26.59±3.48), (28.59±3.27) points, the differences between the two groups were statistically significant (P<0.05);the time of lying in bed was (1.85±0.57) d, shorter than that in the perinatal intervention group for(4.85±0.48) d, the difference between the two groups was statistically significant (P<0.05).The amount of postpartum hemorrhage in vaginal delivery group was (232.96±12.65) ml, was less than (381.96±23.67) ml in cesarean delivery group, the difference was statistically significant (P<0.05).There was no significant difference in Apgar score between the two groups (P＞0.05).Conclusion Cesarean section and vaginal delivery have no significant effect on the newborn.The former has mild pain and good psychological condition, but with more amount of postpartum hemorrhage and long time in bed.Each has advantages and disadvantages appropriate delivery can be selected under.

Objective To investigate the timing of prevention and treatment of postpartum hemorrhage of uterine contractions （PPH） by Carbendazim Aminobutanol Injection, and then to guide the prevention and treatment of PPH.Methods A total of 180 cases of PPH tendency treated in our hospital from August 2017 to August 2019 were selected as the study subjects, and they were divided into group A, group B and group C according to the random digital table method, 60 cases in each group.group A：after the delivery of the fetus, the uterine muscle was injected with 250 μg of Carbendazim Injection and intravenous drip of 20 U Oxytocin.Group B：after deliver, drop 20 U Oxytocin, if the bleeding amount reached 400 ml, the uterine muscle was injected with 250 μg of Carbendazim Triol Injection.Group C：after delivery of the fetus, the uterine muscle was injected with 20 U Oxytocin and intravenous drip of 20 U Oxytocin, when the bleeding amount reached 800 ml, the uterine muscle was injected with 250 μg of Carbendazim Triol Injection.The incidence of 24 h postpartum hemorrhage, postpartum hemorrhage, prenatal and postnatal hemoglobin and adverse reactions during medication in the two groups were evaluated.Results The amount of postpartum hemorrhage in group A was less than that in group B and group C, and that in group B was less than that in group C，with statistical differences (P<0.05);the incidence of postpartum hemorrhage in group A was lower than that in group B and group C, with statistical difference (P<0.05).There was no significant difference in the incidence of postpartum hemorrhage in group C and group B (P＞0.05).The hemoglobin level of the three groups at 24 hours after delivery was lower than that before delivery, with statistical differences (P<0.05), the level of 24 h hematocrit in group A was higher than that in group B and group C, with statistical difference (P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups (P＞0.05).Conclusion Carbendazim Tributanol Injection can prevent and treat the PPH better, using Carbendazim Tributanol Injection as early as possible to reduce the amount of postpartum hemorrhage, reduce the incidence of postpartum hemorrhage and ensure the safety of parturient.

Objective To explore the clinical effect of Bifidobacterium Triple Living Bacteria Powder combined with Montmorillonite Powder in the treatment of infantile diarrhea.Methods A total of 80 children with diarrhea treated in our hospital from January 2018 to October 2019 were selected and divided into Montmorillonite Powder group (n=40)and Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group (n=40).Group were treated with Montmorillonite Powder combined with Triple Live Bacteria Powder The children in the Montmorillonite Powder combined with Triple Live Bacteria Powder.The curative effect of diarrhea was compared between the two groups;the time for stool characteristics to return to normal state, the time for stool defecation times to reach normal range, the time for body temperature to return to normal range, the score of diarrhea symptoms, nutritional index and adverse drug reactions before and after treatment were compared.Results The curative effect of diarrhea in the Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group was higher than that in the Montmorillonite Powder group, the difference was statistically significant (P<0.05).The time for stool character to return to normal state, the time for defecation frequency to reach normal range and the time for body temperature to return to normal range in Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group were shorter than those in Montmorillonite Powder group, and the differences were statistically significant (P<0.05).The score of diarrhea symptoms in the Montmorillonite Powder combined with Bifidobacterium Triple Live Bacteria Powder group was lower than that in the Montmorillonite Powder group, and the nutritional index was higher than that in the Montmorillonite Powder group, and the differences were statistically significant (P<0.05).There was no significant difference in adverse drug reaction between the two groups (P＞0.05).Conclusion Montmorillonite powder combined with Bifidobacterium Triple Live Bacteria Powder is effective in the treatment of diarrhea, compared with Montmorillonite Powder,Montmorillonite Powder can effectively improve diarrhea and nutritional status with high safety and no serious adverse reactions.

Objective To explore the effect of Montelukast Sodium combined with Budesonide aerosol inhalation in the treatment of children with asthma.Methods A total of 86 cases of children with asthma treated in our hospital from August 2017 to December 2019 were selected as the research objects.The selected patients were divided into the observation group (n=43) and the control group (n=43) according to random number table method.The children in the control group were treated with Budesonide aerosol inhalation, and the children in the observation group were treated with Montelukast Sodium combined with Budesonide aerosol inhalation, the changes of clinical treatment effect, peak expiratory flow (PEF) and forced expiratory volume in the first second (FEV1) of the two groups were observed.Results After treatment, the FEV1 and PEF of the two groups of children were higher than those before treatment, the differences were statistically significant (P<0.05).The FEV1 and PEF in the observation group after treatment were higher than those in the control group, the differences were statistically significant (P<0.05).Through treatment, the total effective rate of children in the observation group was 95.35%, higher than the control group (81.40%), the difference was statistically significant (P<0.05).The total incidence of adverse reactions in the observation group was 2.33%, lower than the control group (13.95%), the difference was statistically significant (P<0.05).Conclusion Montelukast Sodium combined with Budesonide aerosol inhalation in the treatment of bronchial asthma has a significant effect, can significantly improve the lung function of children, clinical application value is high.

Objective To investigate the application effect of ultrasound-guided bilateral transverse abdominal muscle block combined with general anesthesia in radical resection of colorectal cancer.Methods A total of 70 cases of patients who underwent radical colorectal cancer treatment from January 2015 to July 2016 in our hospital were selected as the research subjects.According to the random number table method, they were divided into the observation group and the control group, 35 cases in the each group.The control group was selected under general anesthesia, the observation group was selected ultrasound-guided bilateral transverse abdominal muscle block combined with general anesthesia.The effects of anesthesia, the amount of general anesthetic drugs during the operation, vital signs indicators and the recovery time of postoperative consciousness were compared between the two groups.Results There was no significant difference in the excellent and good rate of anesthesia between the two groups (P＞0.05).The dosage of Propofol and Sufentanil in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in the duration of anesthesia between the two groups (P＞0.05).There were no significant differences in the heart rate and mean arterial pressure of the two groups between before and after anesthesia (P＞0.05).The recovery time of eyes opening, swallowing reflex and orientation force in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion Ultrasound-guided bilateral transverse abdominal muscle block combined with general anesthesia can reduce the dosage of general anesthesia drugs and accelerate the recovery of postoperative consciousness on the premise of ensuring the anesthesia effect and duration of colorectal cancer radical operation.

Objective To investigate the influence of target-directed fluid therapy during anesthesia on the rapid recovery of elderly patients after gastrointestinal surgery.Methods From September 2017 to September 2019, 80 elderly patients in our hospital who needed to be hospitalized for gastrointestinal surgery were selected as the research subjects.They were divided into the conventional liquid treatment groups (40 cases) and the target-directed liquid therapy group (40 cases) according to the random number table method.The conventional liquid-treated group took conventional liquid therapy, and the target-directed liquid therapy group took target-directed liquid therapy during anesthesia.The anesthesia excellent rate, average extubation time, intraoperative infusion volume, average hospitalization time, average heart rate and average arterial pressuree of elderly patients undergoing gastrointestinal surgery during anesthesia,postoperative complications were compared between the two groups.Results The excellent and good rate of the goal-directed liquid treatment group was higher than that of the conventional liquid treatment group, and the difference was statistically significant (P＜0.05).The heart rate and mean arterial pressure of the target-directed fluid treatment group were lower than those of the conventional fluid treatment group, and the differences were statistically significant (P＜0.05).The average extubation time and average hospitalization time in the goal-directed fluid treatment group were shorter than those in the conventional fluid treatment group, and the amount of infusion during the operation in the goal-directed fluid treatment group was less than that in the conventional fluid treatment group, and the differences were statistically significant (P＜0.05).The total incidence of complications in the target-directed fluid treatment group was lower than that in the conventional fluid treatment group, and the difference was statistically significant (P＜0.05).Conclusion Target-directed fluid therapy during anesthesia has a good effect on the rapid recovery of elderly patients after gastrointestinal surgery, and the effect is accurate, and it also plays an important role in maintaining the hemodynamic stability of the elderly patients, improving the cerebral oxygen supply of the elderly patients and reducing the incidence of postoperative complications.

Objective To explore the clinical effect of Oxycodone combined with Propofol in hysteroscopic anesthesia,and to provide reference for clinical anesthesiologists to choose a reasonable anesthesia regimen.Methods From January 2018 to December 2019, 70 patients who received hysteroscopic surgery in Tiemei General Hospital of Liaoning Health Industry Group were selected as the study objects.According to the random number table method, the study objects were divided into the control group and the observation group, 35 cases in each group.The control group was anesthetized with routine anesthesia, the observation group was anesthetized with Oxycodone and Propofol.The heart rate, mean arterial pressure, postoperative pain and adverse reactions were compared between the two groups.Results There was no significant difference in the heart rate and mean arterial pressure between the two groups before anesthesia and when consciousness-regaining (P＞0.05).The pain scores at each time point in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The clinical anesthesia effect of Oxycodone combined with Propofol in hysteroscopic surgery is clear, the postoperative analgesia effect is good, and the adverse reaction rate is low, the application effect is significant.

Objective To investigate the influence of laryngeal mask airway and tracheal intubation on flatulence and postoperative nause and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy.Methods A total of 90 patients undergoing elective laparoscopic cholecystectomy at Changzhou Traditional Chinese Medicine Hospital from September 2016 to September 2017 were enrolled.According to the random number table methods, they were divided into the tracheal intubation (T) group, the laryngeal mask pressure control ventilation (P) group and the laryngeal mask volume control ventilation (V) group, 30 cases in each group.Ultrasound was used to measure changes in gastric antrum area (GAA) after successful placement of the laryngeal mask or tracheal tube (T0) and after surgery (T1), and the incidence of PONV were compared between the three groups.Results There were no significant differences in GAA between the three groups at T0 (P＞0.05).The GAA of group V and group P at T1 were larger than those at T0, the differences were statistically significant (P＜0.05).The GAA at T1 of group V and group P were larger than those of group T,the differences were statistically significant (P＜0.05).The incidence of PONV of group V and group P were higher than that of group T, and the differences were statistically significant (P＜0.05).Conclusion Compared with conventional tracheal intubation, the degree of gastric distention and the incidence of PONV after general anesthesia with LMA are significantly increased.

Objective To investigate the clinical effect of Remifentanil intravenous controlled analgesia anesthesia on labor analgesia in primiparae.Methods From July 2018 to August 2019, 60 cases of primiparae admitted in our hospital were selected as the study objects.According to the random number table method, they were divided into two groups, 30 cases in each group.The control group underwent epidural block controlled analgesia anesthesia method,and the study group underwent Remifentanil intravenous controlled analgesia anesthesia method.The analgesic effect of primiparae between the two groups were observed and compared.Visual analogue scale (VAS) scores, heart rates (HR),and mean arterial pressure (MAP) were compared between the two groups at different time periods.Adverse birth outcomes and adverse reactions were compared between the two groups.Results The excellent and good rate of analgesia in the study group was higher than that in the control group, the difference was statistically significant (P<0.05).There were no significant differences in VAS scores, HR, and MAP between the two groups before analgesia (P>0.05).The VAS scores, HR, and MAP in the study group were lower than those in the control group at 15, 30 and 60 min after analgesia, the differences were statistically significant (P<0.05).There was no significant difference in the total incidence of adverse delivery outcome between the two groups (P>0.05).There was no significant difference in the overall incidence of adverse reactions between the two groups (P>0.05).Conclusion The application of Remifentanil intravenous controlled analgesia anesthesia is helpful to improve the pain degree of primiparae, improve the related symptom indicators, increase the good and good rate of analgesia, and do not increase the incidence of adverse delivery outcome, which has important clinical application value

Objective To investigate the clinical application effect of ultrasound-guided transversus abdominis plane block (TAPB) in cesarean section under general anesthesia.Methods From May 2018 to October 2019, 60 pregnant women underwent cesarean section under general anesthesia in Nanshan District Maternal and Child Health Hospital of Shenzhen City were selected as the research subjects.They were divided into observation group and control group by random number table method, 30 cases in each group.The control group received general anesthesia cesarean section,and the observation group received ultrasound guided TAPB before operation on the basis of the control group.The time from anesthesia induction to fetal delivery, operation time, intraoperative blood loss, dosage of Remifentanil, blood pressure and heart rate were compared between the two groups.Postoperative colostrum time and visual analogue scale(VAS) score were recorded.The Apgar score, neurological and adaptive capacity score (NACS) after birth were compared between the two groups.Results The dosage of Remifentanil in the observation group was less than that in the control group, and the difference was statistically significant (P<0.05).After delivery of the fetus, systolic blood pressure and heart rate in the observation group were higher than those in the control group, with statistically significant differences (P<0.05).The VAS scores at 2, 4, 12 and 24 h after surgery in the observation group were lower than those in the control group, with statistically significant differences (P<0.05).The colostrum time in the observation group was earlier than that in the control group, and the difference was statistically significant (P<0.05).The VAS scores at 4, 12 and 24 h after surgery in both groups were lower than those at 2h after surgery, with statistically significant differences(P<0.05).The Apgar score 1 min after birth in the observation group was higher than that in the control group, with statistically significant difference (P<0.05).There was no statistically significant difference between the two groups in Apgar score at 5 min after birth (P>0.05).There were no significant difference in NACS scores at 24 and 48 h after birth between the two groups (P>0.05).NACS scores of the two groups at 48 h after birth were compared with those of those at 24 h after birth, and the differences were not statistically significant (P>0.05).Conclusion Ultrason-guided TAPB application in general anesthesia cesarean section can reduce the influence of general anesthesia drugs on parturient women, reduce postoperative pain and fetal inhibition, worthy of clinical recommendation.

Objective To explore the relationship between the changes of early renal artery hemodynamics and its endothelin-1 (ET-1) of plasma in primary hyperuricemia with school-age children.Methods A total of 112 school-age children (aged 6-12 years old) who had health examination in our hospital from June 2018 to September 2019 were selected as the study subjects.Renal function, serum uricacid, ET-1 of pasma and color Doppler ultrasound of both kidneys and renal arteries were examined.According to the blood uricacid level, they were divided into the hyperuricemia group (40 cases) and the healthy group (72 cases).According to the blood flow resistance of each segment of renal artery, the hyperuricemia group were divided into the resistance index (RI)＞0.7 group (20 cases) and the RI≤0.7 group(20 cases).the relationship between the changes of early renal artery hemodynamics and its ET-1 of plasma in primary Hyperuricemia with school-age children was analyzed.Results The RI of the left interlobular artery in the hyperuricemia group was higher than that in the healthy group, the difference was statistically significant (P＜0.01).The concentration of ET-1 of plasma of the hyperuricemia group was higher than that of the healthy group, the difference was statistically significant (P＜0.05).The mean value of ET-1 of plasma in the RI＞0.7 group was (212.35±196.52) pg/ml,which was higher than that in the RI ≤0.7 group ([102.51±46.54]pg/ml), the difference was statistically significant(P＜0.05).Conclusion Primary hyperuricemia in schoolage children may cause the increase of renal arteriole blood flow resistance, which may cause the increase of ET-1 of plasma.The increase of ET-1 concentration in those with increased renal arteriole blood flow resistance is more obvious, which suggests that primary hyperuricemia in school-age children may cause the disorder of renal arteriole inner skin function, and then may cause the increase of renal arteriole resistance

Objective To explore the clinical diagnostic value of X-ray in patients with gouty arthritis.Methods A total of 80 patients with gouty arthritis admitted to our hospital from November 2017 to November 2019 were selected as the observation subjects.All patients underwent X-ray and computed tomography (CT) examinations.The detection rate of gout nodules, bone defects, joint changes, soft tissue swelling, subchondral cystic changes, soft tissue calcification using the two methods was compared.X-ray performance of early gouty arthritis, mid-term gouty arthritis, late gouty arthritis was analyzed.Results The detection rates of X-ray examination for gout nodules, bone defects, joint changes,soft tissue swelling, subchondral cystic changes, and soft tissue calcification were 60.00%, 85.00%, 78.75%, 73.75%,66.25%, and 82.50% respectively.The CT detection rates of gout nodules, bone defects, joint changes, soft tissue swelling, subchondral cystic changes, and soft tissue calcification were 61.25%, 87.50%, 81.25%, 75.00%, 68.75%, and 83.75% respectively, there were no statistical differences in these data using the two methods (P＞0.05).There were no significant differences in the accuracy, sensitivity and specificity between X-ray and CT examinations (P＞0.05).The average cost of X-ray examination was (76.28±7.46) yuan, and which was (233.61±21.55) yuan in CT examination, with statistical difference (P＜0.05).By X-ray detection, 36 patients with early gouty arthritis manifested as a clearly defined oval or fusiform soft tissue shadow at the affected joint, which was a reversible change.A total of 27 patients with midterm gouty arthritis manifested as nodular uplift in asymmetric soft tissue adjacent to the joint, irregular depression and lobulated shape occurred adjacent to the bone, the edge of the bone appearing as a spur-like lifting of the eggshell,and urate deposited in the articular cartilage which showed a chisel-like cystic destruction after bone erosion.A total of 17 patients with late gouty arthritis manifested as a remarkable enlargement trend in the eccentric soft tissue mass,severe damage on the bone, and linear hardening, quasi-circular holes, severe collapse of the joint surface, and narrowing of the joint surface in the edge of the bone.Conclusion Patients with gouty arthritis undergoing X-ray examination have a high detection rate and is sensitive, and the examination cost is low, with good imaging performance.

Objective To investigate the characteristics of solitary pulmonary nodules (SPN) by dynamic CT enhanced scanning.Methods The clinical data of 100 patients with SPN admitted in our hospital from May 2017 to May 2019 were analyzed retrospectively, included 62 patients with lung cancer, 30 patients with pulmonary nodules and 8 patients with pulmonary tuberculosis.All patients underwent dynamic enhanced CT scanning, and the enhanced manifestations of SPN in dynamic contrast-enhanced scan and CT value measurement results of lesions in plain scan and dynamic enhanced scan were analyzed.Results In 62 cases of lung cancer, there were 32 cases of heterogeneous enhancement, 29 cases of homogeneous enhancement and 1 case of peripheral enhancement.Among 30 cases of pulmonary nodules, 18 cases were enhanced unevenly, and 12 cases were enhanced uniformly.There was no obvious enhancement in 8 cases of pulmonary tuberculosis, after enhancement, the CT value increased ＜20 Hu.The plain CT value of lung cancer were lower than that of enhanced CT value in each phase, the differences were statistically significant (P＜0.05).There was no significant difference in CT value of lung cancer in different phases (P＞0.05).The plain CT value of pulmonary nodules were lower than those of the enhanced CT value in each phase, and the differences were statistically significant(P＜0.05).The CT value of 30 s enhanced pulmonary nodules were lower than those of 60 s, 120 s and 180 s enhanced pulmonary nodules, the difference were statistically significant (P＜0.05).There were significant differences in CT value between 60 s, 120 s and 180 s of pulmonary nodules enhancement (P＜0.05).There were no significant differences in CT value of tuberculoma between the plain scanning and enhanced phases (P＞0.05).Conclusion Benign and malignant SPNs have the unique consolidate characteristics of enhanced dynamic CT.The time-density curve within the 30-second enhancement period of the lung cancer is obviously rising, the time-density curve of the pneumonia nodule is gradually rising, and the time-density curve the SPN of tuberculosis is flat.

Objective To analyze the reasons for the return of unqualified Chinese medicine pieces in our hospital and take corresponding improved measures to ensure the safety of clinical medication.Methods A total of 197 batches of Chinese medicine pieces returned from 2016 to 2019 in our hospital were selected as the research objects.Based on the return records, Excel software was used to analyze the reasons for the return.Results The main reasons for the return were fakes and adulteration (9.1%), dyeing (3.0%), weight gain (10.2%), extraction of drug residue (1.0%), fumigation with sulfur (15.2%), oil brimming (12.2%), unqualified processing (27.9%), mixed use of local standard varieties(6.1%), mixed use of national pharmacopoeia standard varieties (7.1%), and others (8.1%).There were 12 tenders in total from 2016 to 2019 with 1591 batches, and 197 batches were returned accounting for 12.4%.Conclusion The reasons for the return of unqualified Chinese medicine pieces in our hospital mainly include unqualified processing, fumigation with sulfur, oil brimming, etc.Based on the above-mentioned main reasons for return, our hospital has put forward four improved measures and strictly implemented them, which has greatly improved the quality of Chinese medicine pieces in our hospital.

The cultivation of the talented personnel is the key link for all professions and trades, and is the focus of personnel work in research institutions of various enterprises and institutions.As for the discipline of traditional Chinese medical history and literature, there were few researches on the talented personnel cultivation mode in the past.This study investigated the current situation of talented personnel in 7 research institutes of traditional Chinese medical history and literature, like Research Institute of Chinese Medical History, China Academy of Chinese Medical Sciences,Shanghai Literature Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine,Nanjing University of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, and the Institute for the History of Natural Sciences, Chinese Academy of Sciences, systematically analyzed the outward manifestation of the talented personnel cultivation of traditional Chinese medical history and literature, and explored the suitable talented personnel cultivation mode for literature institute of the history of the traditional Chinese medicine, so as to provide reference for the related institutes to cultivate talented personnel.

Objective To evaluate the data of the malignant tumor registration report from January 2005 to December 2016 in Xigang District of Dalian City in the aspects of data reliability and registration completeness, so as to provide a basis for further improving the quality of tumor registration.Methods All morbidity and mortality cases diagnosed as malignant tumors in Xigang District of Dalian City from January 2005 to December 2016 were exported from Dalian Cancer Registration Report Management System.Through SAS programming, the data were merged, deduplicated, summarized and analyzed, and statistical charts were generated.Results The proportion of histopathology (MV%) in Xigang District from January 2005 to December 2016 was 72.88%, cases with death certificate notification (DCN) accounted for 18.78%, and cases with death certificate only (DCO) accounted for 2.85%.There was still a certain gap from the national standard of <15%.The ratio of the number of deaths to the number of new cases (M/I) was 0.41, which did not reach the standard of 0.6-0.8.The percentage of new cases of malignant tumors registered in the same period, with other unspecified sites and unknown primary sites (secondary) (O&U%) was 3.13.Conclusion The MV% in Xigang District from January 2005 to December 2016 is higher than the national standard.However, the number of DCN cases has been in an increasing trend in recent years, reaching 35.54% in 2016.M/I is 0.41, less than the standard of 0.6-0.8, which is related to the high incidence rate of thyroid cancer, breast cancer and other tumors with good prognosis in Dalian City.The O&U% is 3.13%, but increases to 4.24% in 2016.In recent years, it has been gradually increasing, but the overall level is not high.In general,the reliability of tumor registration data in Xigang District of Dalian City is relatively high, but the completeness is not high, so it needs to be strengthened urgently.

Objective To understand the basic situation and causes of medication error (ME) in our hospital and put forward preventive measures, so as to provide reference for hospital medication management.Methods A retrospective analysis of the ME monitoring report reported by our hospital from April 2012 to July 2018 to the international network rational use of drug, China central group clinical safety drug monitoring network was conducted, the error factors, error content, error classification and location were extracted, and contextual, modal and psychological classification was made according to the occurrence and the drugs involved.Results There were 687 cases of ME from April 2012 to July 2018, and the top 3 categories were the central nervous system (14.39%), anti-tumor drugs (13.66%) and hormones and related medications (11.45%).There were 158 cases of ME involved high-alert medications, most of which were insulin(36.71%) and parenteral or oral chemotherapy medication (25.32%).Pharmacists (81.22%) were the main discoverers of ME.ME mainly occurred in dispensing stage(87.77%),and the main contributing factors were look alike and sound alike(42.62%), followed by inadequate review (22.22%) and fatigue (13.27%).And there were mainly action-based (45.11%)and memory-based (30.85%) errors in dispensing stage.The main factor leading to ME in the prescribing stage was lacking knowledge (65.79%).Conclusion Through monitoring and reporting ME, the causes of ME can be continuously discovered and understood.In addition, it′s of great significance for patients′ medication safety to improve the medical staff′s cognition of ME and strengthen the training of pharmacists in checking prescription.

Sodium Valproate as a mood stabilizer is widely used in patients with bipolar disorder, which is also effective for rapid cycling and mixed episodes about bipolar disorder.The damage of Sodium Valproate to liver function cannot be ignored.The use of Sodium Valproate in patients with POLG gene mutation will aggravate the damage of liver function, and even cause liver failure, leading to death of the patients.This article reports a case in which POLG gene mutation was detected during the early use of Sodium Valproate in the treatment of bipolar disorder and Sodium Valproate was discontinued in time.And through this case, it is recommended that psychiatrists should perform POLG gene analysis before treatment with Sodium Valproate, especially in patients suspected with mitochondrial disease.

This article summarized the nursing points of a case of hand-foot syndrome complicated by ultrasoundguided radiofrequency ablation in patients with liver metastasis after colon cancer surgery, so as to guide clinical nursing work.Through comprehensive assessment of the patient′s condition, such as disease progression, mental state, condition change, family social relations, etc., psychological nursing, fistula nursing, hand-foot syndrome observation and nursing, pain nursing, rest and diet guidance, health education should be done well.After nursing intervention, the expected therapeutic effect was effectively achieved, and the patient was discharged smoothly.It is suggested that good nursing of ultrasound-guided radiofrequency ablation of colon cancer liver metastases complicated with hand-foot syndrome can effectively improve the quality of life of patients and prevent serious complications and adverse reactions.

Acute suppurative thyroiditis is rarely seen in the clinic, and its clinical manifestations are complex and diverse, and it is easy to be misdiagnosed or missed.If it is not diagnosed and treated in time, the whole condition will be delayed and it will develop to be potentially fatal.This article analyzes and summarizes a patient with acute suppurative thyroiditis caused by Granulicatella adiacens admitted to our hospital on August 5, 2019.Combining the actual morbidity and diagnosis and treatment process, the clinical manifestations, diagnosis, differential diagnosis and treatment measures of the disease are discussed.It is suggested that clinicians should always be alert to patients with anterior cervical pain, after abscess formation, drainage of the abscess or incision to drain the pus and complete debridement should be performed as soon as possible.

Objective To study the application effect of early warning intervention nursing on neonatal jaundice.Methods Altogether 80 cases of neonatal jaundice treated in our hospital from September 2017 to September 2019 were selected and divided into control group and observation group according to the simple random method, 40 cases in each group.The control group was given routine jaundice nursing, and the observation group was given early warning intervention nursing based on the control group.The jaundice risk degree and bilirubin level of the two groups were compared.The nursing satisfaction and the incidence of adverse events of parents in the two groups were studied.Results Before the intervention, there were no statically significant differences in bilirubin level and risk degree score between the two groups (P＞0.05);after intervention for 5 days, the bilirubin level and risk degree scores of the two groups were lower than those before the intervention;the bilirubin level and risk degree scores of observation group were lower than those of control group, with statistical differences (P<0.05);after intervention for 5 days, the total satisfaction degree of family members of the observation group was higher than that of the control group, with statistical difference (P<0.05).There was no statistically significant difference in the total incidence of adverse events between the two groups(P＞0.05).Conclusion Application of the early warning mechanism and corresponding nursing can improve the symptoms of jaundice newborn babies and promote the recovery of jaundice effectively, which has significant nursing effect and clinical value.

Objective To explore the application of motivational nursing in patients with thyroid adenoma surgery.Methods Seventy-two patients with thyroid adenoma who were treated in our hospital from April 2017 to April 2019 were selected as the research objects.They were divided into the control group (n=36) and the observation group (n=36)according to random number table method.The routine nursing intervention method was adopted the control group, and the observation group adopted the motivational nursing intervention method.The psychological stress indexes and physiological stress indexes of the two groups were compared.Results The self-rating anxiety scale (SAS) and self rating depression scale (SDS) scores of theobservation group were lower than those of the control group, and the differences were statistically significant (P<0.05).The systolic blood pressure, diastolic blood pressure, and heart rate of the observation group were lower than those of the control group, and the differences were statistically significant (P<0.05).Conclusion Motivational nursing care for patients with thyroid adenoma surgery can effectively relieve patients′ anxiety and depression, stabilize systolic blood pressure, diastolic blood pressure and heart rate, improve psychological and physiological stress response, promote postoperative rehabilitation, and have significant nursing effect.]

Objective To explore the application effect of strengthening self-care intervention in patients with vocal cord polypectomy under laryngoscope.Methods From February 2018 to June 2019, 62 patients with vocal cord polypectomy under laryngoscope treated in Dongguan Qishi Hospital were selected and divided into two groups according to random number table method, 31 cases in each group.The control group was given routine care, the study group was given intensive self-care intervention.The ability of self-care at admission and 3 months and the recovery of voice function at 1 and 3 months after operation were compared between the two groups.Results There were no significant differences in the scores of self-care skills, self-care knowledge, self-concept and self-care responsibility between the two groups (P＞0.05).The scores of self-care skills, self-care knowledge, self-concept and self-care responsibility in the self-care ability test table of the two groups at 3 months after operation were higher than those, the differences were statistically significant (P<0.05).The scores of self-care skills, self-care knowledge, self-concept and self-care responsibility in the test table of self-care ability in the study group were higher than those in the control group, the differences were statistically significant (P<0.05).The recovery rate of voice function in the study group was higher than that in the control group at 1 month after operation, the difference was statistically significant (P<0.05).Comparison of the recovery rate of voice function between the two groups at 3 months after operation showed no statistically significant difference (P＞0.05).Conclusion Strengthening self-care intervention in patients with vocal polypectomy under laryngoscope can improve their self-care ability and promote the recovery of voice function.

Objective The application value of the combined application scheme of WeChat platform and mobile health software in the elderly patients with chronic obstructive pulmonary disease (COPD).Methods A total of 100 elderly patients with COPD who were discharged from our hospital from March 2016 to April 2018 were selected as the research subjects.They were divided into the study group (n=50) and control group (n=50) according to the random number table method.Patients in the control group were given health lectures and telephone follow-up methods.Patients in the study group were given combined application scheme of WeChat platform and mobile health software.The self-efficacy level, management level, and medication compliance were compared between the two groups.Results In the study group, patients′self-management level (including symptom management score, emotional management score, daily life score, self-efficacy score, and information management score), efficacy levels (including negative scores, emotional scores, physical activity scores, environmental scores, and risk behavior scores) and medication compliance were higher than those in the control group, and the differences were statistically significant (P<0.05).Conclusion The combined application scheme of WeChat platform and mobile health software has high application value for the continuous care of elderly patients with COPD, and it is worthy of widespread clinical application.

Objective To explore the application effect of quality control circle activities in elderly patients with type 2 diabetes mellitus （T2DM）.Methods A total of 64 patients with T2DM receiving hypoglycemic drugs in our hospital were selected.Since March 2018, quality control circle activities had been implemented.Twelve months before the start of the activity (September 2017 to September 2018) were listed as before activity and twelve months after the start of the activity (January to December 2019) were listed as after activity.Before the activity, the patients were given routine nursing, including medication guidance, dietary guidance, health exercise guidance and so on.After the activity, the patients were given quality control circle activity on the basis of routine nursing.The implementation process of quality control circle included the establishment of quality control circle team, theme selection, current situation analysis, goal setting, cause analysis and countermeasures formulation.The correctness rate of oral medication and the quality control circle score (problem solving ability, communication and coordination ability, team cohesion, self-confidence, enthusiasm, responsibility and quality control circle manipulation) were compared before and after activities.Results The correct rate of taking medicine after activity was 90.63%, which was higher than that before activity, the difference was statistically significant (P<0.05).The scores of problem-solving ability, communication and coordination ability, team cohesion, self-confidence, initiative, responsibility and quality control circle skills of the group members after the activity were higher than those before the activity, the differences were statistically significant (P<0.05).Conclusion Quality control circle activities can effectively improve the correct rate of taking therapeutic drugs for elderly patients with T2DM, and strive to improve the professional level and quality of nursing staff, improve the quality of nursing service, which is worthy of clinical application.

Objective To explore the application effect of humanistic care intervention in nursing of long-term hospitalized elderly psychiatric patients.Methods Thirty-one elderly psychiatric patients with long-term hospitalization in Guangzhou Hui′ai Hospital from October 2018 to January 2019 were selected as research subjects.They were divided into experimental group (n=14) and control group (n=17) by drawing lottery using simple random sampling.Patients in the experimental group were intervened with humanistic care on the basis of routine nursing, while patients in the control group received routine nursing alone.The nurses′ observation scale for inpatient evaluation (NOSIE) score and inpatient′s satisfaction score of the two groups were compared.Results The social ability, social interest, total positive factor scores, total NOSIE score, and hospitalization satisfaction in the experimental group after intervention were higher than those before intervention as well as those in the control group, with statistical differences (P<0.05).The irritability score was lower than that before the intervention in this group and that in the control group, the differences were statistically significant (P<0.05).There were no significant differences in the scores of individual cleanliness, mental illness, retardation, depression, and total negative factors between the two groups (P＞0.05).Conclusion Humanistic care intervention can improve patients′ social ability and enthusiasm for life to a certain extent, and increase hospitalization satisfaction.

Objective To study the application effect of Compound Polymyxin B Ointment to smear the inner ring depression of the disposable prepuce ring cutting stapler in the treatment of patients with circumcision.Methods From December 2016 to December 2018, 94 cases of prepuce and stem-covered male patients in our hospital were selected as study subjects.They were divided into experimental group and control group by the method of random digital table,47 patients in each group.The patients in both groups were treated with prepuce.The patients in the control group were smeared with medical lubricant on the inner ring depression of the prepuce ring cutting stapler, while the patients in the experimental group were given Cmpound Polymyxin B Ointment to smear the inner ring depression of the disposable prepuce ring cutting stapler.The postoperative pain level of the two groups was compared with the assessment of visual analogue scale (VAS), and the incidence of postoperative infection and postoperative adhesion in the two groups was statistically compared, and the satisfaction of the patients was compared.Results The VAS score of the experimental group was lower than that of the control group, and the difference was statistically significant (P＜0.05）.The incidence of infection and postoperative adhesion in the experimental group was 4.26%, 2.13%, which was lower than that in the control group (17.02%, 12.77%), the differences were statistically significant (P＜0.05）.The total satisfaction of the experimental group was 93.62%, which was higher than that of the control group (78.72%) (P＜0.05).Conclusion The application of Compound Polymyxin B Ointment in prepuce ring can reduce the degree of pain, reduce the complications such as infection and adhesion, promote wound healing and improve the satisfaction of patients, which is worthy of clinical application.

Objective To explore the application effect of comprehensive nursing in patients with adhesive intestinal obstruction after abdominal surgery.Methods A total of 80 patients with postoperative adhesive intestinal obstruction treated in our hospital from January 2017 to January 2019 were selected as research subjects.They were divided into control group (n=40) and observation group (n=40) by drawing lots.Conventional nursing was adopted in the control group, and comprehensive nursing was applied in the observation group.The quality of life, body behavior status score and clinical indicators were compared between the two groups.Results After nursing, the life quality score and body behavior status score of the observation group were higher than those of the control group, and the differences were significant (P<0.05).The recovery time of gastrointestinal function, the time of first exhaust, and the time of first defecation in the observation group were shorter than those of the control group, and the differences were statistically significant (P<0.05).Conclusion In the active treatment of patients with adhesive intestinal obstruction after abdominal surgery, implementing comprehensive nursing for patients can significantly enhance nursing effect, improve various clinical indicators, and improve the life quality and behavior status of patients.It has a high application value in the clinic.

Objective To explore the application effect of comprehensive nursing intervention in the elderly patients with chronic obstructive pulmonary diseases (COPD) by Budesonide inhalation therapy.Methods Totally 50 elderly patients with COPD who were admitted to our hospital from May 2018 to September 2019 were selected as research subjects.They were divided into observation group and control group according to random grouping method, 25 cases in each group.Budesonide inhalation therapy was applied to both groups.Patients in the control group received routine nursing intervention, and in the observation group, they received comprehensive nursing intervention.The oral care status and mental state between the two groups were compared.Results After intervention, the pH of the two groups of patients was higher than that before intervention, and the difference was statistically significant (P<0.05);after intervention, the pH of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05).After intervention, the score of self-anxiety scale (SAS) of the two groups was lower than that before intervention, and the difference was statistically significant (P<0.05);after intervention, the SAS score of the observation group was lower than that of the control group (P<0.05).The hospital stay in the observation group was shorter than that of the control group, and the differences were statistically significant (P<0.05).The incidence rates of oral leukoplakia and oral fungal infection in the observation group were lower than those of the control group, and the differences were statistically significant (P<0.05).Conclusion The effect of comprehensive nursing intervention on elderly patients with COPD with Budesonide inhalation therapy is remarkable.

Objective To explore the effect of thermal insulation nursing on surgical stress and anesthesia recovery with undergoing laparoscopic cholecystectomy (LC) under general anesthesia.Methods A total of 80 cases with cholecystolithiasis and/or cholecystitis undergoing LC admitted to our hospital from March 2018 to September 2019 were selected and divided into two groups according to random number table method, 40 cases in each group.The control group implemented routine nursing.The observation group was given the heat preservation nursing, then the body temperature measurement results during anesthesia recovery (when anesthesia stopped, when entering the recovery room and when entering the recovery room for 15 min) were compared.The changes of stress-related factors during anesthesia recovery were compared between the two groups.The related indexes of anesthesia awakening between the two groups were compared：the time of opening eyes, the time of assisted ventilation by anesthesia machine, time of tracheal catheter removal and the total time of stay in resuscitation room.The sedation score standard for anaesthetic awakening (Ramsay)change trend was compared between the two groups during anesthesia recovery period (when anesthesia stopped, when entering the recovery room and when entering the recovery room for 15 min).Results The body temperature in the observation group was higher than that in the control group (when anesthesia was stopped, when entering the resuscitation room and when entering the resuscitation room for 15 min), the difference was statistically significant (P<0.05).The stress-related factor malondialdehyde (MDA) during anesthesia and resuscitation was lower than that of the control group, the difference was statistically significant (P<0.05), the level of superoxide dismutase (SOD) was higher than that of the control group, the difference was statistically significant (P<0.05).In the related indexes of anesthesia recovery, the opening time of eyes, the assistant ventilation time of anesthesia machine, time of extubation and the total stay time in the resuscitation room in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05).The Ramsay score in the observation group was higher than that in the control group (when anesthesia was stopped, when anesthesia entered the resuscitation room and when anesthesia entered the resuscitation room for 15 min), the difference was statistically significant (P<0.05).Conclusion For patients undergoing LC under general anesthesia, real-time thermal insulation nursing can effectively maintain body temperature stability and reduce stress response and promote anesthesia recovery.

Objective To explore the application effect of comprehensive nursing in patients with acute angle-closure glaucoma.Methods A retrospective analysis of 76 patients with acute angle-closure glauco ma treated in our hospital from October 2018 to September 2019 was made.They were divided into control group (n=38) and observation group(n=38) according to different nursing methods.The control group used conventional nursing methods, and the observation group adopted comprehensive nursing methods.Nursing total satisfaction, postoperative eye recovery and mental status scores between the two groups were compared.Results After the nursing intervention, the total satisfa ction of the patients in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).The visual acuity levels of the two groups after nursing were higher than those before nursing, and the anterior chamber depth and intraocular pressure were low er than those before nursing.The differences were statistically significant (P<0.05).The vision level of the patients in the observation group was higher than that in the control group,and the anterior chamber depth and intraocular pressure were lower than those in the control group.The difference was stati stically significant (P<0.05).The anxiety and depression score of the two groups after nursing were lower than those before nursing, the anxiety and de pression score of the observation group were lower than those of the control group,and the differences were statistically significant (P<0.05).Conclusion Patie nts with acute angle-closure glaucoma receiving comprehensive nursing intervention can improve patients′ vision level, reduce anterior chamber depth and intraocular pressure, improve mental state, and have higher quality of nursing.

Objective To analyze the application effect of predictive nursing procedure in elderly patients with dementia (AD) treated by Nimodipine combined with Donepezil Hydrochloride.Methods A total of 80 patients with AD treated in our hospital from January 2018 to January 2019 were selected as study subjects.They were divided into control group (n=40) and study group (n=40) according to the even-odd method.Both groups were treated with Nimodipine combined with Donepezil Hydrochloride.During the treatment period, patients in the control group received routine nursing intervention, while in the study group, they received predictive nursing procedure intervention.The improvement of quality of life, occurrence of complications, and patient′s satisfaction on nursing work were compared in the two groups.Results The four quality of life scores in the study group were higher than those in the control group, and the differences were statistically significant (P<0.05).The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05).The total satisfaction of nursing in the study group was higher than that in the control group, with statistical difference (P<0.05).Conclusion The application of predictive nursing procedure in the nursing of elderly patients with AD has significant effect.It can effectively reduce the incidence of complications, and improve the quality of life and patient′s satisfaction on nursing.Therefore, it is worthy of clinical research and promotion.

Objective To explore the application effect of pre-habilitation intervention for patients after laparoscopic cholecystectomy (LC).Methods A total of 78 LC patients who were admitted to our hospital from April 2018 to January 2019 were selected as the study objects.According to the time of admission, they were divided into the observation group and the control group, 39 cases in each group.The control group was given routine care during perioperative period, and the observation group was given pre-habilitation intervention.The anxiety and pain scores, hospital stay, time of anal exhaust, and the total incidence of postoperative complications between two groups were compared.Results After pre-habilitation intervention, the scores of anxiety and pain and the total incidence of postoperative complications in the observation group were lower than those in the control group, while the hospitalization time and anal exhaust time in the observation group were shorter than those in the control group, the differences were statistically significant(P<0.05).Conclusion The application of pre-rehabilitation model can accelerate the recovery after LC.

Objective To discuss the application effect of individual skill training in rehabilitation nursing of vagrant mental patients.Methods A total of 92 cases of vagrant psychosis admitted to our hospital from January 2017 to January 2019 were selected, they were divided into observation group and control group by randomized double-blind method, 46 cases in each group.The control group was given routine rehabilitation nursing and the observation group was given individual skill training on the basis of the control group.The recovery state scale (MRSS), positive and negative symptom scale (PANSS) scores and self-knowledge and treatment attitude questionnaire (ITAQ) were compared between the two groups, when they came to hospital and after six months of nursing care, and their recurrence were observed.Results After 6 months of nursing care, the scores of PANSS and MRSS in the two groups were lower than those at admission, the ITAQ scores were higher than that at admission and the ITAQ score in the observation group was higher than that in the control group, the scores of PANSS and MRSS were lower than those in the control group, and the differences were statistically significant (P＜0.05）.After 6 months of nursing, the recurrence rate of the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05）.Conclusion The application of individual skill training in the rehabilitation nursing of vagrant mental patients is significant.It can improve the clinical mental symptoms, improve the ability of self-care, and it is worth popularizing in clinical practice.

Objective To explore the application of humanistic nursing concept in patients with esophageal cancer radiotherapy.Methods A total of 100 patients with radiotherapy for esophageal cancer who were admitted to our hospital from February 2018 to February 2019 were selected as the research subjects.They were divided into the control group(50 cases) and the observation group (50 cases) according to a dynamic randomized method.The control group adopted routine nursing, the observation group adopted humanistic nursing.The quality of life score, anxiety, depression score,and nursing total satisfaction were compared between the two groups.Results The quality of life score in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).The anxiety and depression scores in the observation group were lower than those in the control group, and the nursing total satisfaction in the observation group was higher than that in the control group, the differences were statistically significant(P<0.05).Conclusion Patients with radiotherapy for esophageal cancer have certain application effect in choosing humanistic nursing interventions, which can effectively improve the quality of life of patients, improve negative emotions,and increase patient satisfaction with nursing staff.It is worthy of further clinical promotion and application.