Objective To explore the effect of Huai′er Granules in radiochemotherapy for patients with nasopharyngeal carcinoma.Methods A total of 60 patients with nasopharyngeal carcinoma who underwent concurrent radiotherapy and chemotherapy from January 2014 to January 2016 were selected as the research objects.The selected patients were divided into the control group and the observation group by simple randomization, 40 cases in each group.The control group was treated with concurrent chemoradiotherapy, and the observation group was treated with concurrent chemoradiotherapy combined with Huai′er Granules.One month after the treatment was completed, the changes in T cell expression, clinical efficacy, and quality of life of patients of the two groups before and after treatment were analyzed.Results The total effective rate of clinical treatment of patients between the two groups was not statistically significant (P>0.05).After treatment, the expression levels of CD3+, CD4+, CD4+/CD8+ cells in two groups were higher than before treatment, and the expression levels of CD3+, CD4+, CD4+/CD8+ cells in the observation group were higher than those in control group, the differences were statistically significant (P<0.05).After treatment, the expression level of CD8+ cells in two groups were lower than those before treatment, and the expression level of CD8 + cells in the observation group was lower than that in control group (P<0.05).After radiochemotherapy, the physical function score of the observation group was higher than that in the control group, and the meanwhile, the fatigue, nausea/vomiting and pain scores in observation group were lower than those in control group, the differences were statistically significant (P<0.05).Conclusion Huai′er Granule can effectively improve the immune function of nasopharyngeal carcinoma after radiotherapy and chemotherapy at the same time, and can also improve the quality of life of patients.It is worthy of further clinical research.