Objective To investigate the clinical application effect of ultrasound-guided transversus abdominis plane block (TAPB) in cesarean section under general anesthesia.Methods From May 2018 to October 2019, 60 pregnant women underwent cesarean section under general anesthesia in Nanshan District Maternal and Child Health Hospital of Shenzhen City were selected as the research subjects.They were divided into observation group and control group by random number table method, 30 cases in each group.The control group received general anesthesia cesarean section,and the observation group received ultrasound guided TAPB before operation on the basis of the control group.The time from anesthesia induction to fetal delivery, operation time, intraoperative blood loss, dosage of Remifentanil, blood pressure and heart rate were compared between the two groups.Postoperative colostrum time and visual analogue scale(VAS) score were recorded.The Apgar score, neurological and adaptive capacity score (NACS) after birth were compared between the two groups.Results The dosage of Remifentanil in the observation group was less than that in the control group, and the difference was statistically significant (P<0.05).After delivery of the fetus, systolic blood pressure and heart rate in the observation group were higher than those in the control group, with statistically significant differences (P<0.05).The VAS scores at 2, 4, 12 and 24 h after surgery in the observation group were lower than those in the control group, with statistically significant differences (P<0.05).The colostrum time in the observation group was earlier than that in the control group, and the difference was statistically significant (P<0.05).The VAS scores at 4, 12 and 24 h after surgery in both groups were lower than those at 2h after surgery, with statistically significant differences(P<0.05).The Apgar score 1 min after birth in the observation group was higher than that in the control group, with statistically significant difference (P<0.05).There was no statistically significant difference between the two groups in Apgar score at 5 min after birth (P>0.05).There were no significant difference in NACS scores at 24 and 48 h after birth between the two groups (P>0.05).NACS scores of the two groups at 48 h after birth were compared with those of those at 24 h after birth, and the differences were not statistically significant (P>0.05).Conclusion Ultrason-guided TAPB application in general anesthesia cesarean section can reduce the influence of general anesthesia drugs on parturient women, reduce postoperative pain and fetal inhibition, worthy of clinical recommendation.