学龄儿童原发性高尿酸血症早期肾动脉血流与血浆内皮素-1变化关系的研究

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Abstract

Objective To explore the relationship between the changes of early renal artery hemodynamics and its endothelin-1 (ET-1) of plasma in primary hyperuricemia with school-age children.Methods A total of 112 school-age children (aged 6-12 years old) who had health examination in our hospital from June 2018 to September 2019 were selected as the study subjects.Renal function, serum uricacid, ET-1 of pasma and color Doppler ultrasound of both kidneys and renal arteries were examined.According to the blood uricacid level, they were divided into the hyperuricemia group (40 cases) and the healthy group (72 cases).According to the blood flow resistance of each segment of renal artery, the hyperuricemia group were divided into the resistance index (RI)＞0.7 group (20 cases) and the RI≤0.7 group(20 cases).the relationship between the changes of early renal artery hemodynamics and its ET-1 of plasma in primary Hyperuricemia with school-age children was analyzed.Results The RI of the left interlobular artery in the hyperuricemia group was higher than that in the healthy group, the difference was statistically significant (P＜0.01).The concentration of ET-1 of plasma of the hyperuricemia group was higher than that of the healthy group, the difference was statistically significant (P＜0.05).The mean value of ET-1 of plasma in the RI＞0.7 group was (212.35±196.52) pg/ml,which was higher than that in the RI ≤0.7 group ([102.51±46.54]pg/ml), the difference was statistically significant(P＜0.05).Conclusion Primary hyperuricemia in schoolage children may cause the increase of renal arteriole blood flow resistance, which may cause the increase of ET-1 of plasma.The increase of ET-1 concentration in those with increased renal arteriole blood flow resistance is more obvious, which suggests that primary hyperuricemia in school-age children may cause the disorder of renal arteriole inner skin function, and then may cause the increase of renal arteriole resistance

Key words： School-age children Primary hyperuricemia Renal artery hemodynamics Endothelin-1 of plasma Variation relation

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