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2020 Vol. 27, No. 9
Published: 2020-03-28

 
 
4 Preparation of coenzyme Q10 liposome and its anti-ultraviolet damage effect
10 liposome and its anti-ultraviolet damage effect[J]. 中国当代医药, 2020,27(9): 4-')" href="#"> WU Hai-you; WU Yi; WU Tie
Objective To study the preparation of coenzyme Q10 liposome and its anti-ultraviolet damage effect.Methods The coenzyme Q10 liposomes were prepared by injecting ethanol,then animal experiments were performed.A total of 32 SPFmice were randomly divided into normal(CON)group,model(MOL)group,coenzyme Q10 liposome(COQ)group,and titanium dioxide(TiO2)group,8mice in each group.Themice in the CON group were not subjected to any treatment after depilation,and the remaining groups ofmice were smeared with the corresponding cream and irradiated with ultraviolet rays every day after depilation.Among them,the MOL group was smeared with the blank cream,the COQ group was smeared with the coenzyme Q10 liposome,and the TiO2 group was smeared with the TiO2 cream.The irradiation dose was theminimum amount of erythema,and the experiment lasted 8 weeks.After the end of the experiment,the skin pathology and the contents of malondialdehyde(MDA),superoxide dismutase(SOD),and matrix metalloproteinase(MMP-1),glutathione peroxidase(GSH-Px)in themice were determined.Results The optimum formulation of coenzyme Q10 liposome showed as the temperature was 60°C,the water phase of pH was 7.7 and other was 0.9%of coenzyme Q10 and 1.6%of lecithin.The encapsulation efficiency of coenzyme Q10 liposome was 44.7%,and the liposome was uniform in size and globular.The MDA content and the relative expression of MMP-1 in skin tissue of the mice in the MOL group were higher than those in the CON group,and the SOD contentwas lower than that in the CON group,with statistically significant differences(P<0.05).The SOD content in the skin tissue of themice in the COQ group was higher than that in the MOL group,and the relative expression of MMP-1 was lower than that in the MOL group,the differences were statistically significant(P<0.05).The MDA content in the skin tissue of themice in the TiO2 group was lower than that in the MOL group,and the difference was statistically significant(P<0.05).The GSH-Px content in the skin tissue ofmice in the COQ group was higher than that in other groups,and the differences were statistically significant(P<0.05).Conclusion The prepared coenzyme Q10 liposome is uniform in size and has anti-ultraviolet damage effect onmice skin.
2020 Vol. 27 (9): 4- [Abstract] ( 101 ) HTML (55 KB)  PDF  (0 KB)  ( 9 )
9 Study on the correlation between quantification of gout urate deposition and blood uric acid level by energy spectrum CT
WANG Zhong-qi; LI Guan; BIN Jun-jie
Objective To study the correlation between the quantitative determination of urate deposition and blood uric acid level by energy spectrum CT.Methods Sixty-eight patients with chronic gout treated in our hospital from January 2018 to January 2019 were recruited in the gout group,and another 68 patients with asymptomatic and nonimaging hyperuricemia who were treated in our hospital during the same period were selected as the reference group.All patients were performed with energy spectrum CT examinations.The energy spectrum CT examinations of two groups were compared,such as calcium urate concentration in the soft tissue adjacent to the first metatarsophalangeal joint,bone cortex,cancellous bone and blood uric acid concentration,the correlation was analyzed.The changes in the soft tissues adjacent to the first metatarsophalangeal joint,the total volume of uric acid crystals in the feet and ankles,and themaximum individual volume of uric acid crystals in patients with gout before and after treatmentwere observed.Results The level of blood uric acid and the concentration of calcium urate in the soft tissue adjacent to the first metatarsophalangeal joint in the gout group were higher than those in the reference group,and the differences were statistically significant(P<0.05).There were no significant differences in the calcium urate concentrations of cancellous bone and cortical bone between the two groups of patients(P>0.05).There was amoderate positive correlation between blood uric acid level and calcium urate concentration in the soft tissue adjacent to the first metatarsophalangeal joint(r=0.703,P<0.05),and therewas no significant correlation with calcium urate concentration in cancellous bone and cortical bone(r=-0.005,r=-0.067,P>0.05).The blood uric acid level of patients with gout was highly positively correlated with the total volume of uric acid crystals in the feet and ankles and the maximum individual volume of uric acid crystals(r=0.981,r=0.990,P<0.05).After treatment of gout patients,the concentration of calcium urate in the soft tissue adjacent to the first metatarsophalangeal joint,the total volume of uric acid crystals in the feet and ankles,and the maximum individual volume of uric acid crystals were lower than those before treatment,and the differences were statistically significant(P<0.05).Conclusion Energy spectrum CT test can confirm that there is definitely positive correlation between urate deposition in gout patients and the concentration of calcium urate in the soft tissue adjacent to the first metatarsophalangeal joint and blood uric acid level,and both indicators are reversible and can be improved after regular treatment.
2020 Vol. 27 (9): 9-12 [Abstract] ( 89 ) HTML (37 KB)  PDF  (0 KB)  ( 13 )
13 Effect of Dexmedetom idine on electroencephalogram bispectral index and hemodynam ics in pediatric laparoscopic surgery under general anesthesia with laryngealmask
YANG Yuan-qi; XU Shu-qi; CHEN Jin-yu; LIU Guang-sheng; XIAO Jin-ping; ZHOU Zhi-nuan
Objective Toexplore theeffect of Dexmedetomidine on electroencephalogram bispectral index(BIS)and hemodynamics in pediatric laparoscopic surgery under general anesthesiawith laryngealmask.Methods A total of 120 children undergoing laparoscopic surgery under general anesthesia with laryngealmask admitted to our hospital from August 2017 to May 2019 were selected as research objects.They were divided into control group(n=60)and experimentalgroup(n=60)according to the random number table method.In thecontrolgroup,normalsalinewas intravenously pumped,and in the experimental group,Dexmedetomidine was intravenously pumped.The BIS value,systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)were observed before medication(T0),3 min after administration(T1),and 6min after administration(T2),9min after administration(T3),12min after administration(T4),15 min after administration(T5),before intubation(T6),1 min after intubation(T7),3 min after intubation(T8)between the two groups.Results There were no significant differences in BIS values between the two groups of children from T0 to T3(P>0.05).At T4 and T5,the BIS values of children in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in BIS values between the two groups of children from T6 to T8(P>0.05).The BIS values at T1,T2,T3,T4,T5,T6,T7,and T8 in both groups were lower than those at T0,and the differences were statistically significant(P<0.05).There were no significant differences in SBP,DBP and MAP between the two groups of children at each time(P>0.05).The SBP,DBP,and MAP at T1,T2,T3,T4,T5,T6,T7,and T8 of the two groups were lower than those at T0,and the differences were statistically significant(P<0.05).Conclusion Dexmedetomidine can not only reduce the BIS value of pediatric laparoscopic surgery under general anesthesia with laryngealmask,but also can stabilize hemodynamic indexes in children.
2020 Vol. 27 (9): 13-16 [Abstract] ( 87 ) HTML (59 KB)  PDF  (0 KB)  ( 6 )
17 Research progress in diabetes health management
RAO Li-hua; TAO Yi-jing; RAO Dong-hua
Diabetes is a common endocrine and metabolic disease which is one of the most important chronic diseases threatening human health.In addition to conventional therapy,healthmanagement plays an important role in effectively reducing the development of diabetes and its complications.This article reviews the healthmanagement elements of diabetes,aiming to promote the formation of a virtuous cycle of"health management-regularmonitoring-prevention and control-control of blood sugar",and further provide ideas for the diagnosis and treatment of diabetes.
2020 Vol. 27 (9): 17-20 [Abstract] ( 83 ) HTML (36 KB)  PDF  (0 KB)  ( 12 )
21 Research advances in interference factors of(1,3)-β-D-glucan test
MA Xing-xuan; TANG Shi-fu; YANG Jian-ling; HUANG Yi-yong; LONG Kang; ZHANG Hong-yu
(1,3)-β-D-glucan test is an index of invasive fungal infection for the diagnosis of deep organs and tissues such as internal organs and subcutaneous tissues of fungal infections.It is of great help to clinical diagnosis and treatment,but as an experimental indicator,there are always some interference factors in the process of detection,which makes the test result false positive or false negative.This article summarizes the domestic and foreign literature on the(1,3)-β-D-glucan test interference factors,and reviews them,so as to provide guidance for the clinical application of(1,3)-β-D-glucan test and provide reference for the study of interference factors in(1,3)-β-D-glucan test.
2020 Vol. 27 (9): 21-23 [Abstract] ( 88 ) HTML (31 KB)  PDF  (0 KB)  ( 11 )
24 Research progress of reactive oxygen species and anti-oxidation in inflammatory bowel diseases
CHEN Li-fei; ZHANG Shi-chang; XIAO Lin; LYU Kai-jie; LI Zhi-qing
Inflammatory bowel diseases(IBDs)which include Crohn′s disease and ulcerative colitis are themost common intestinal dysfunction.Reactive oxygen species(ROS)plays a key role in pathogenesis of IBDs.ROS which includes superoxide radicals(O2-),hydroxyl radicals(-OH),hydrogen peroxide(H2O2),singlet oxygen(1O2)and other peroxide is responsible for cell apoptosis via oxidation of DNA,proteins,lipids,and any other cellular constituent.To protect biological systems form overdose of ROS,the anti-oxidation system of cells is activated to regulate the production of ROS.Due to the lack of research on ROS and anti-oxidation system in patients with IBDs,especially in pediatric patients,it is necessity for comprehensive study of ROS and anti-oxidation mechanisms in IBDs.This review deepens the understanding of the occurrence and developmentmechanisms of IBDs,with a view to providing ideas for clinical treatments,targeted vector and targeted drugs.
2020 Vol. 27 (9): 24-27 [Abstract] ( 78 ) HTML (43 KB)  PDF  (0 KB)  ( 13 )
28 Research progress of therapy-related asymptomatic intracranial hemorrhage in acute ischem ic stroke
SU Jie-hua; REN Hui-jie; ZENG Guan-wen; LI Zhao-hui
Asymptomatic intracranial hemorrhage is a common complication in acute cerebral infarction,which occurs more frequently in patients with reperfusion therapy.However,because it does not cause serious clinical consequences,it is often ignored.More and more clinical studies show that therapy-related asymptomatic intracranial hemorrhage is associated with slow recovery of neurological function and poor long-term prognosis.This article reviews the definition,pathogenesis,risk factors,predictionmethods,prognosis,prevention and treatment of therapy-related asymptomatic intracranial hemorrhage in acute ischemic stroke,aiming to provide a reference for clinicians to evaluate the risk of asymptomatic hemorrhage transformation in the treatment of acute cerebral infarction reperfusion.
2020 Vol. 27 (9): 28-32 [Abstract] ( 91 ) HTML (44 KB)  PDF  (0 KB)  ( 10 )
33 Effect of blood glucose on first implantation pacing parameters of patients undergoing permanent pacemaker implantation
MO Hai-liang; WU Zi-jun; HUANG Rui-na; CHEN Lu-jun; SUN Qi-fan; WU Keng
Objective To investigate the effect of blood glucose on first implantation pacing parameters of patients undergoing permanent pacemaker implantation.Methods A total of 231 patients undergoing permanent pacemaker implantation treated in the hospital from March 2014 to March 2019 were selected as the subjects,and retrospective analysis was conducted.According to the blood glucose,they were divided into group A(patients with diabetes,42 cases),group B(patients with impaired glucose tolerance,118 cases)and group C(patients with normal blood glucose,71 cases).The pacing threshold,perception,impedance,program-controlled test time of pacemaker parameters were compared among the three groups.The correlation between blood glucose and pacing parameterswas analyzed.Results The ventricular pacing threshold,perception,impedance in group A and group B were higher than those in group C,and the program-controlled test time of parameters was longer than that in group C,and the differences were statistically significant(P<0.05).There was no statistically significant difference in ventricular pacing threshold,perception or impedance between the group A and group B(P>0.05).The ventricular parameter programmable test time in group A was longer than that of group B,the difference was statistically significant(P<0.05).The levels of fasting blood glucose(FBG)and blood glucose 2 hours aftermeal(2 h BG)in group A and group B were higher than those in group C,and the FBG and 2 h BG levels of group A were higher than those of group B,the differences were statistically significant(P<0.05).Spearman correlation analysis showed that FBG was positively correlated with pacing threshold,perception,impedance and program-controlled test time of parameters(r=0.410,0.352,0.332,0.318;P<0.05).And 2 h BG was positively correlated with the pacing threshold,perception,impedance and program-controlled test time of parameters(r=0.425,0.367,0.346,0.327;P<0.05).Conclusion Blood glucose has influence on the pacing threshold,impedance and perception of patients undergoing pacemaker implantation.High blood glucose will lead to elevated pacing threshold and impedance,decreased sensitivity and prolongation of program-controlled test time of parameters.
2020 Vol. 27 (9): 33-36 [Abstract] ( 97 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
37 Clinical effect of Tiotropium Bromide combined with Formoterol inhalation in the treatment of chronic obstructive pulmonary disease
LIU Wen-hua
Objective To investigate the clinical effect of Tiotropium Bromide combined with Formoterol inhalation in the treatmentof chronic obstructive pulmonary disease.Methods Sixty patients with chronic obstructive pulmonary disease admitted to our hospital from February 2017 to February 2019 were selected as the research subjects,and they were divided into the control group(30 cases)and the observation group(30 cases)according to the random number table method.Patients in the control group were treated with Tiotropium Bromide alone,and patients in the observation group were given Tiotropium Bromide combined with Formoterol inhalation.The clinical efficacy and incidence of adverse reactions of the two groups of patients were observed,and the lung function(forced expiratory volume in one second[FEV1],forced vital capacity[FVC],FEV1 to FVC ratio[FEV1/FVC]),maximal voluntary ventilation(MVV)],dyspnea scale(MRC)score and 6min walking distance(6MWD)before and after treatmentwere compared between the two groups of patients.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The FEV1,FVC,FEV1/FVC,and MVV after treatment in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The MRC score of patients in the observation group was lower than that in the control group,the 6MWD was farther than that in the control group,and the differences were statistically significant(P<0.05).No serious adverse reactions occurred during the treatment of the two groups.Conclusion Tiotropium Bromide combined with Formoterol inhalation in the treatment of patients with chronic obstructive pulmonary disease has significant effect,it can increase pulmonary function,improve dyspnea,enhance exercise tolerance,and promote outcome of the disease,which has certain safety.
2020 Vol. 27 (9): 37-39转43 [Abstract] ( 87 ) HTML (35 KB)  PDF  (0 KB)  ( 5 )
40 Clinical effect of Bufei Huoxue Capsules in the treatment of chronic pulmonary heart disease
DAI Lian-ying; ZHAO Bin; FU Chun-sheng
Objective To investigate the clinical therapeutic effect of Bufei Huoxue Capsules of patients with chronic pulmonary heart disease and its effect on pulmonary function.Methods From April 2017 to April 2019,90 patients with chronic pulmonary heart disease who were treated in our hospital were randomly selected as the subjects of the study.The patients were divided into study group and reference group by random number table method,with 45 cases in each group.The patients in the control group were treated with routine therapy,and the patients in the research group were treated with Bufei Huoxue Capsules.The treatment effect,pulmonary function,quality of life and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of patients in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the forced vital capacity(FVC),one-second vital capacity(FEV1)and maximum expiratory velocity(PEF)of the patients in the study group after treatmentwere higher than those in the control group,with statistically significant differences(P<0.05).After treatment,the scores of physical function,social function and mental state of patients in the study group were higher than those in the control group,with statistically significant differences(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of chronic pulmonary heart disease with Bufei Huoxue Capsules has remarkable curative effect,significantly improves the pulmonary function of the patients,and has high safety,so it is worth popularizing widely.
2020 Vol. 27 (9): 40-43 [Abstract] ( 90 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
44 Effect and safety of Levofloxacin in the treatment of multidrug-resistant pulmonary tuberculosis
WU Cheng-bo
Objective To analyze the effect and safety of Levofloxacin in the treatment of multidrug-resistant pulmonary tuberculosis.Methods Eighty patients withmultidrug-resistant pulmonary tuberculosiswho were treated in our hospital from January 2018 to January 2019 were selected as the research objects,and they were divided into the control group(n=40)and the observation group(n=40)by the random listmethod.Patients in the control group received conventional drug treatment,and patients in the observation group received Levofloxacin treatment on the basis of the control group.The therapeutic effect,levels of inflammatory factors(tumor necrosis factor-α [TNF-α],interleukin-6[IL-6],interleukin-1 [IL-1])before and after treatment and the total incidence rate of adverse reactions were observed in the two groups.Results The total effective rate of treatment in the observation group was 97.50%,which was higher than that in the control group accounting for 82.50%,and the difference was statistically significant(P<0.05).The levels of TNF-α,IL-6 and IL-1 after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of TNF-α,IL-6 and IL-1 after treatment in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).During the drug treatment period,the total incidence rate of adverse reactions in the observation group was 15.00%,compared with 12.50%in the control group,and the difference was not statistically significant(P>0.05).Conclusion Levofloxacin in the treatment of patients withmultidrug-resistant pulmonary tuberculosis can significantly reduce the level of inflammatory factors and improve the therapeutic effect.At the same time,patients have fewer adverse reactions and have higher safety,which is worthy of being promoted and applied.
2020 Vol. 27 (9): 44-46 [Abstract] ( 78 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
47 Application effect of transnasal high flow hum idification oxygen therapy in patients with acute exacerbation of chronic obstructive pulmonary disease
HUANG Fei
Objective To investigate the application effect of transnasal high flow humidification oxygen therapy(HHFNC)in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods From October 2017 to October 2018,85 patients with acute exacerbation of COPD treated in respiratory department of our hospital were selected as the subjects of study.They were divided into control group(n=42)and study group(n=43)by the random number table method.The patients in the control group were treated with noninvasive positive pressure ventilation for respiratory support,while the study group was treated with HHFNC for respiratory support.The changes of respiratory frequency(R),arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)and oxygen index(OI)after treatmentwere compared between the two groups.The rate ofmechanical ventilation of tracheal intubation,treatment compliance and treatment complications were counted.Results The R and PaCO2 of the two groups after treatmentwere lower than those before treatment,PaO2 and OIwere higher than those before treatment,the differences were statistically significant(P<0.05).Therewere no significant differences in R,PaCO2,PaCO2 and OIbetween the two groups after treatment(P>0.05).There was no significant difference in the rate ofmechanical ventilation of tracheal intubation between the two groups(P>0.05).The treatment compliance of the study group was higher than that of the control group,and the total incidence of complicationswas lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion Respiratory support therapy with HHFNC in patients with acute exacerbation of COPD can effectively improve the ventilation function of patients,and the compliance of patients is good and the complications are few,so it is valuable to popularize and apply.
2020 Vol. 27 (9): 47-49 [Abstract] ( 73 ) HTML (33 KB)  PDF  (0 KB)  ( 15 )
50 Clinical effect of small incision thyroidectom y in treatment for benign thyroid tumors
HE De; ZHOU Xing-jian; WEN Jia-qi; QIN Zhang-lu
Objective To investigate clinical effect of small incision thyroidectomy in treatment for benign thyroid tumors.Methods A total of 90 patients with benign thyroid tumorswho had undergone unilateral lobectomy treated in the Departmentof Thyroid Surgery of Pingxiang People′s Hospital from December 2016 to December 2018 were selected as subjects.Patients were divided into control group and observation group according to the different surgical incision.In the control group,72 patients were treated with traditional thyroid surgery,and in the observation group,50 patients were treated with small incision thyroidectomy.Postoperative pain scoreswere compared between the two groups.Surgical indications(operative time,intraoperative bleeding volume,postoperative drainage time,postoperative pain time)were compared between the two groups.The total incidence of complications(hoarseness,neck compression,dyspnea,subcutaneous nodules,incision infection)were compared between the two groups.Results Postoperative pain score in observation group after operation was lower than that in control group,the difference was statistically significant(P<0.05).Therewas no difference in the operation time between the two groups(P>0.05).The postoperative drainage time and postoperative pain time in observation group were shorter than that in control group,the differences were statistically significant(P<0.05).The intraoperative bleeding volume in observation group was less than that in control group,the differencewas statistically significant(P<0.05).The total incidence of complications in observation group was lower than that in control group,the differencewas statistically significant(P<0.05).Conclusion Small incision thyroidectomy has significant effect in treatment for benign thyroid tumors,which has the advantages of small trauma,quick recovery,beautiful appearance,light pain,high safety.That is worthy of clinical application.
2020 Vol. 27 (9): 50-52转56 [Abstract] ( 76 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
53 Effect of Azithrom ycin combined with Cefotaxime Sodium on pulmonary function in patients with chronic obstructive pulmonary disease
LIANG Wei; HUANG Jian-ling
Objective To investigate the effect of Azithromycin combined with Cefotaxime Sodium on pulmonary function in patients with chronic obstructive pulmonary disease.Methods One hundred patients with chronic obstructive pulmonary disease admitted to Shekou People′s Hospital from April 2017 to April 2018 were selected as the subjects of this study,and were divided into the control group(n=50)and the study group(n=50)by random lottery.The control group was treated with conventional basic treatment,while the study group was treated with Azithromycin combined with Cefotaxime Sodium.The lung function indexes before and after treatment,the clinical symptom scores before and after treatment,and the clinical treatment effect were compared between the two groups.Results Before treatment,there were no significant differences in the forced vital capacity(FVC),maximum ventilator volume(MVV),and forced expiratory volume in 1 second(FEV1)between the two groups(P>0.05).After treatment,the FVC of patients of the study group was(2.40±0.45)L,the MVV was(88.95±2.65)L/min,and the FEV1 was(1.88±0.13)L,which were higher than those in the control group([2.15±0.20]L,[80.10±1.15]L/min,[1.40±0.35]L),the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the scores of chronic cough and expectoration,shortness of breath,wheezing chest tightness,and fatigue and weight loss between the two groups(P>0.05).The score of chronic cough and expectoration after treatment was(1.18±0.07)points,the score of shortness of breath after treatment was(1.05±0.01)points,the score of wheezing chest tightness after treatment was(1.18±0.06)points,and the score of fatigue and weight loss after treatmentwas(1.38±0.04)points in the study group,all lower than those in the control group([1.85±0.05],[2.21±0.05],[2.03±0.07],[1.96±0.07]points),the differences were statistically significant(P<0.05).The total effective rate was 96.00%in the study group,which was higher than that in the control group accounting for 76.00%(P<0.05).Conclusion The treatment of Azithromycin combined with Cefotaxime Sodium in patients with chronic obstructive pulmonary disease ismore effective,can effectively improve the lung function index and symptom index,and has important clinical application value.
2020 Vol. 27 (9): 53-56 [Abstract] ( 88 ) HTML (37 KB)  PDF  (0 KB)  ( 13 )
57 Clinical effect of Edaravone combined with Vinpocetine Injection in the treatment of acute cerebral infarction
YANG Yu-sheng; LIU Zhen-peng; HUANG Yao-zhong
Objective To explore the clinical effect of Edaravone combined with Vinpocetine Injection in the treatment of acute cerebral infarction(ACI).Methods Seventy patients with ACI treated in Lufeng People′s Hospital from January 2018 to March 2019 were selected as research subjects.They were divided into the control group and the observation group according to the random number table method,with 35 cases in each group.Patients in the control group were treated with Edaravone,and patients in the observation group were treated with Vinpocetine Injection on the basis of the control group.The clinical efficacy,incidence of adverse reactions,and neurological function(national institute of health stroke scale[NIHSS])score,inflammatory factors(tumor necrosis factor-α[TNF-α),and matrix metalloproteinase-3[MMP-3])and oxidative stress(superoxide dismutase[SOD],malondialdehyde[MDA])levels before and after treatmentwere compared between the two groups.Results The total effective rate of treatment in the observation group was 97.14%,which was higher than 77.14%in the control group,and the difference was statistically significant(P<0.05).The NIHSS score of patients in the observation group after treatment was(9.61±1.80)points,which was lower than that in the control group of(12.36±2.19)points,and the difference was statistically significant(P<0.05).The levels of TNF-αand MMP-3 in the observation group after treatmentwere(72.31±15.22)and(2.63±0.62)μg/L,which were lower than those in the control group for(95.24±18.45)and(4.11±0.89)μg/L,the differences were statistically significant(P<0.05).The SOD level in the observation group after treatmentwas(39.62±3.50)IU/ml,which was higher than that in the control group for(32.81±2.17)IU/ml,and the MDA level was(9.95±1.16)μmol/L,which was lower than that in the control group for(13.34±1.11)μmol/L,the differences were statistically significant(P<0.05).No serious adverse reactions occurred in both groups.Conclusion The combination of Edaravone and Vinpocetine Injection can effectively improve the neurological function of patients with ACI,enhance the treatment effect,reduce the level of inflammatory factors,regulate the oxidative stress response and speed up the recovery of patients.
2020 Vol. 27 (9): 57-60 [Abstract] ( 86 ) HTML (38 KB)  PDF  (0 KB)  ( 9 )
61 Effect of cognitive behavior combined with Escitalopram Oxalate in the treatment of depression
ZHENG Hui-min; FENG Dong-mei; DAI Juan; LIANG Song-you
Objective To explore effect of cognitive behavior combined with Escitalopram Oxalate in the treatment of depression.Methods A total of 88 patients with depression admitted to our hospital from January 2018 to May 2019 were selected.Patients admitted from January to September 2018 were set as control group(n=44,treated with Escitalopram Oxalate),while patients admitted from October 2018 to May 2019 were set as combination group(n=44,treated with cognitive behavioral therapy combined with Escitalopram Oxalate),the clinical global impression-severity of illness(CGI-SI),Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)scores of depression patients in two groups at different time points after treatmentwere observed.Results At 2,4 and 8 weeks treatment,the CGI-SI,HAMD and HAMA scores of patients in the combined group were lower than those in the control group;at 2,4 and 8 weeks treatment,the CGI-SI,HAMD and HAMA scores of the two groups were lower than those before treatment,the effective rate of the combination group was higher than that of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Cognitive behavior combined with Escitalopram Oxalate for patients with depression can effectively alleviate the severity of depression and improve depression and anxiety,which has guidance value in clinical treatmentof depression.
2020 Vol. 27 (9): 61-63转67 [Abstract] ( 108 ) HTML (35 KB)  PDF  (0 KB)  ( 15 )
64 Application of repeated transcranial magnetic stimulation in long-term hospitalized patients with schizophrenia
QIN Yan-yan; LI Mei-juan; FU Ping-ping; ZHANG Yu-e
Objective To explore the clinical effect of repeated transcranialmagnetic stimulation(rTMS)in long-term hospitalized patients with schizophrenia.Methods Fifty patients with schizophrenia treated in the department of psychiatry in our hospital from February to August 2017 were selected as the research subjects,and were divided into experimental group(n=25)and control group(n=25)according to the order of patient visits.Patients in the control group were given sham stimulation,and patients in the experimental group were provided with rTMS.The scores of the positive and negative symptoms scale(PANSS)before and after 4-and 8-week treatments and 6-month follow-up were compared.Themental nursing observation rating scale(NORS)scores and personal and social performance scale(PSP)before and after treatment were compared.Results The positive symptoms and general mental scores of the experimental group at 4-and 8-week treatments and 6-month follow-up were lower than those of the control group,the total scores of PANSS after 8-week treatment and 6-month follow-up in the experimental group were lower than those of the control group(P<0.05).The self-care ability score of the experimental group after treatmentwas higher than that of the control group,and the PSP scores at 4-and 8-week treatment and 6-month follow-up were higher than those of the control group,the scores of recreational activity,environmental adaptation and mental symptoms,and total score were lower than those in the control group(P<0.05).Conclusion rTMShas a positive effect on the social function and quality of life in long-term hospitalized patients with schizophrenia,and can effectively improve the social function and quality of life.
2020 Vol. 27 (9): 64-67 [Abstract] ( 106 ) HTML (31 KB)  PDF  (0 KB)  ( 12 )
68 Application of ultrasound conductance local drug permeation in postoperative rehabilitation of elbow joint"Terror Trilogy"
RONG Qin; LIANG Jiao; FANG Bing; DENG Xian-chao; HE Gen-lin; CHEN Lu; HUANG Qian
Objective To investigate application effect of ultrasound conductance local drug permeation in postoperative rehabilitation of elbow joint"Terror Trilogy".Methods A total of 30 patients with elbow joint"Terror Trilogy"treated in Pingxiang No.2 People′s Hospital from August 2016 to January 2018 were selected as research objects.They were divided into experimental group(15 cases)and control group(15 cases)by random number table method.The control group received conventional therapy,and the experimental group was treated with ultrasound conductance local drug permeation.The visual analogue scale(VAS)score,swelling degree of elbow joint and joint activity were compared between two groups.Results The VAS score and swelling degree of elbow joint in the experimental group were lower than those in the control group on the 5th,7th and 10th days after operation,and the differences were statistically significant(P<0.05).The joint activity of the experimental group was greater than that of the control group on the 5th,7th and 10th days after operation,and the differences were statistically significant(P<0.05).Conclusion Ultrasound conductance can relieve pain,eliminate swelling and joint activity in patients with elbow joint"Terror Trilogy"after operation.
2020 Vol. 27 (9): 68-70转74 [Abstract] ( 75 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
71 Application of open reduction and p late internal fixation in patients with unstable fracture of distal radius
LAN Fang-ling
Objective To explore the application effect of open reduction and plate internal fixation in patients with unstable fractures of the distal radius.Methods Forty-five patients with unstable distal radius fractures treated in our hospital from June 2014 to June 2018 were selected as the subjects.They were divided into internal fixation group(n=25)and external fixation group(n=20)by random number table method.The internal fixation group was treated with open reduction and plate internal fixation,and the external fixation group was treated with external fixator treatment.The palm tilt,ulnar deflection angle,osseous healing time,wrist mobility,Robbins score of wrist function,clinical efficacy between the two groups were compared.Results The palm tilt and ulnar deflection angle of the patients in the internal fixation group were greater than those in the external fixation group,and the differences were statistically significant(P<0.05).The osseous healing time in the internal fixation group was shorter than that in the external fixation group,and the difference was statistically significant(P<0.05).The palmar flexion,dorsiflexion,pronation,supination of the patients in the internal fixation group were greater than those in the external fixation group,and the differences were statistically significant(P<0.05).There was no significant difference between the two groups in radial and ulnar deflection angle(P>0.05).The Robbins scores ofwrist function in the two groups after treatment were higher than those before treatment(P<0.05).The Robbins score ofwrist function in the internal fixation group was higher than that in the external fixation group,the difference was statistically significant(P<0.05).The total effective rate of treatment in the internal fixation group was 96.0%,which was higher than that in the external fixation group(70.0%),the difference was statistically significant(P<0.05).Conclusion The application effect of open reduction and plate internal fixation in patients with unstable fractures of the distal radius is better than external fixation,and it can effectively expand the patients′palm tilt,ulnar deflection angle,palmar flexion,dorsiflexion,pronation and supination,shorten the osseous healing time,and improve the wrist function of patients,which is worth promoting.
2020 Vol. 27 (9): 71-74 [Abstract] ( 82 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
75 Effect comparison of artificial joint replacement and internal fixation in the treatment of intertrochanteric fracture in the elderly
HUANG He; SONG Xue
Objective To compare the effect of artificial joint replacement and internal fixation in the treatment of intertrochanteric fracture in the elderly.Methods A total of 72 elderly patients with femoral intertrochanteric fracture who were treated in our hospital from January to December in 2017 were selected as the research subjects,they were divided into observation group and control group by random number table method,with 36 cases in each group.The patients in the observation group were treated with artificial joint replacement,while the patients in the control group were treated with internal fixation.The incision length,intraoperative hemorrhage,operative time,postoperative time of descent,postoperative complications and the Harris score at 12 months after operation of the two groups were compared.Results The incision length and operation time of the patients in the observation group were longer than those in the control group,the intraoperative hemorrhage wasmore than that in the control group,and the operation time was shorter than that in the control group,the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The pain,function score and Harris total score of the observation group 12 months after operation were higher than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in deformity and activity scores between the two groups(P>0.05).Conclusion The artificial joint replacement is effective in the treatment of intertrochanteric fractures in the elderly,and the postoperative recovery is rapid and the incidence of complications is low.It is worthy of popularizing and applying in clinical practice.
2020 Vol. 27 (9): 75-77 [Abstract] ( 87 ) HTML (32 KB)  PDF  (0 KB)  ( 5 )
78 Effect of Shenling Baizhu Powder combined with chemotherapy on immune function and quality of life of colorectal cancer
WANG Hao-yong; LI UGuo-rong
Objective To investigate the effect of Shenling Baizhu Powder combined with chemotherapy on immune function and quality of life of colorectal cancer.Methods A total of 84 patients with colorectal cancer admitted to our hospital from June 2016 to December 2018 were enrolled.The randomized digital table method was used to divided patients into observation group and control group,42 cases in each group.The control group only received conventional chemotherapy.On this basis,Shenling Baizhu Powderwas added in the obeservation group,and both groups were treated for 12 weeks.The immune function indicators before and after treatment,the Karnofsky functional status(KPS)score,the occurrence of adverse reactions during the treatment,and the recent clinical efficacy were compared.Results There were no significant differences in the pre-treatment immune function index and KPS score between the two groups(P>0.05).The CD3+,CD4+,CD4+/CD8+levels in the two groups after treatmentwere lower than those before treatment,CD8+,KPS scores were higher than those before treatment,and the differences were statistically significant(P<0.05).The CD3+,CD4+,CD4+/CD8+in the observation group after treatment were lower than those in the control group,and the CD8+and KPSscorewere higher than those in the control group,the differences were statistically significant(P<0.05).The disease control rate of the observation group was 88.10%,which was higher than 69.05%of the control group,and the proportions of hematuria,proteinuria,leukopenia,thrombocytopenia,nausea and vomiting,diarrhea and abdominal pain were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Shenling Baizhu Powder with chemotherapy for patients with colorectal cancer has significant curative effect,which can effectively improve the immune function of patients,improve the quality of life and reduce the adverse reactions of chemotherapy.
2020 Vol. 27 (9): 78-80转84 [Abstract] ( 106 ) HTML (39 KB)  PDF  (0 KB)  ( 11 )
81 Application effect of laparoscopic para-aortic lymphadenectomy in patients with gynecologic malignant tumors
LUO Xiao-qin; WANG Zhang-lin; ZHANG Xiao-wei; LIAO Ya-nan; XU Wen-ling
Objective To investigate the application effect of laparoscopic para-aortic lymphadenectomy in patients with gynecologic malignant tumors.Methods Forty patients with gynecologic malignant tumors treated in Huadu Hospital Affiliated to Southern Medical University from October 2013 to October 2017 were selected as the subjects.They were divided into the laparoscope group(n=20)and the laparotomy group(n=20)by random number table method.The perioperative status,complications and treatment effect between the two groups were compared.Results The hospitalization time,operation time and postoperative exhaust time of patients in laparoscopic group were shorter than those in laparotomy group,the number of lymphadenectomy wasmore than that in open group,and the amount of bleeding was less than that in laparotomy group,the differences were statistically significant(P<0.05).The total complication rate of laparoscopic group was 25.00%,lower than that of the laparotomy group(60.00%),and the difference was statistically significant(P<0.05).One year follow-up,the survival rate of laparoscopic group was 95.00%,compared with 80.00%of the laparotomy group,the differencewas not statistically significant(P>0.05).The lymph nodemetastasis rate of laparoscopic group was 5.00%,lower than 30.00%of the laparotomy group,the difference was statistically significant(P<0.05).Conclusion Laparoscopic para-aortic lymphadenectomy for the treatment of patients with gynecologic malignant tumors can remarkably improve the perioperative treatment and reduce the incidence of complications,which is worthy of clinical application.
2020 Vol. 27 (9): 81-84 [Abstract] ( 80 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
85 Clinical effect of Zoledronic Acid combined with chemotherapy treating bonemetastasis of non-small cell lung cancer
LIU Shuang; QI Ying; LIU Yong
Objective To analyze the clinical effect of Zoledronic Acid combined with chemotherapy treating bone metastasis of non-small cell lung cancer(NSCLC),in order to provide reference for the selection of clinical treatment.Methods The clinical data of 82 patients with NSCLC bonemetastasiswho were treated in our hospital from January 1,2018 to January 1,2019 were analyzed retrospectively.According to the different treatmentmethods,they were divided into two groups.A total of 39 patients who received conventional chemotherapy were set as the control group and 43 patientswho received chemotherapy and Zoledronic Acid as the observation group.The clinical effect,bone pain score and adverse reactions were observed.Results The disease control rate of the observation group(93.02%)was higher than that of the control group(76.92%),the differencewas statistically significant(P<0.05).Before treatment,there was no significant difference between the two groups in numeric rating scale(NRS)score(P>0.05).After treatment,the NRS scores of both groups were lower than those before treatment,the NRSscore of the observation group([1.42±0.91]points)was lower than that of the control group([2.59±1.27]points),the differences were statistically significant(P<0.05).The incidence rates of gastrointestinal reactions,bonemarrow suppression and fever in the observation group and the control group were compared(23.26%vs.30.77%,20.93%vs.17.95%,11.63%vs.7.69%),with no significant difference(P>0.05).Conclusion Zoledronic Acid combined with chemotherapy treating NSCLC bonemetastasis can improve the symptoms of bone pain,inhibit the growth and progress of tumor,and improve the therapeutic effect without increasing adverse reactions.
2020 Vol. 27 (9): 85-87 [Abstract] ( 83 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
88 Clinical effect of small incision extracapsular resection in the treatment of age-related cataract
FENG Wei
Objective To explore the clinical effectof small incision extracapsular resection in the treatment of age-related cataract.Methods A total of 240 patients with age-related cataract treated in our hospital from November 2016 to December 2017 were selected as the subjects.They were divided into study group and control group by computer randomization,with 120 cases in each group.Patients in the study group underwent small incision extracapsular enucleation,and in the control group,they were operated with phacoemulsification.The recovery of vision,the total incidence of complications,astigmatism,corneal cell density and the ratio of hexagonal cells were compared between the two groups.Results The vision recovery rate of patients in the study group was lower than that in the control group 72 hours after operation,and the difference was statistically significant(P<0.05).There were no significant difference in the vision recovery rates of 30 and 90 days after operation between the two groups(P>0.05).Therewas no significant difference in the total incidence of postoperative complications between the two group(P>0.05).There was no significant difference in preoperative astigmatism between the two groups(P>0.05).The astigmatism 72 hours after operation in the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in astigmatism at 30 days and 6months after operation between the two groups(P>0.05).The astigmatism of 72 hours and 30 days after operation in the two groupswas higher than that before operation,the difference was statistically significant(P<0.05).The astigmatism of 6months after operation in the two groupswas not statistically significant(P>0.05).There was no significant difference in corneal cell density or hexagonal cell ratio between the two groups before operation(P>0.05).The corneal cell density and hexagonal cell ratio of the two groups after operation were lower than those before operation,and the corneal cell density and hexagonal cell ratio of the study group after operation were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion Small incision extracapsular resection is effective for age-related cataract patients,which has certain clinical application value.
2020 Vol. 27 (9): 88-90 [Abstract] ( 73 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
91 Application effect of Zishen Mingmu Decoction after surgery of uveitis complicated with cataract
LU Lu
Objective To study the application effect of Zishen Mingmu Decoction after surgery of uveitis complicated with cataract.Methods A total of 85 patients with uveitis complicated with cataract(96 eyes)who underwent surgical treatment in our hospital from April 2018 to February 2019 were selected as the research objects,and they were divided into the control group(42 cases,48 eyes)and the study group(43 cases,48 eyes)according to the random number table method.Patients in the control group were given conventional treatment after surgery,while patients in the study group were given Zishen Mingmu Decoction on the basis of the control group.The postoperative visual acuity recovery,anterior chamber inflammation,intraocular pressure,macular center retinal thickness before and after surgery,clinical effect,incidence of complications and recurrence were compared between the two groups.Results The postoperative visual acuity recovery of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).The intraocular pressure after surgery in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).There were no grade 4 anterior chamber inflammations in the study group at 1 and 7 days after surgery.The anterior chamber inflammations of patients in the study group at 1 and 7 days after surgery were better than those in the control group,and the differences were statistically significant(P<0.05).The macular center retinal thickness in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The clinical effect of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).The incidence rate of complications and recurrence rate of patients in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Zishen Mingmu Decoction in the treatment of uveitis complicated with cataract can significantly improve the visual acuity,facilitate the recovery of intraocular pressure,improve the inflammatory reaction of anterior chamber and corneal index,and it is beneficial to the prognosis of patients,which is suitable for clinical promotion.
2020 Vol. 27 (9): 91-94 [Abstract] ( 76 ) HTML (38 KB)  PDF  (0 KB)  ( 12 )
95 Application effect of Nd:YAG laser in single root canal combined with Vitapex paste treating periapical cysts
YU You-lan
Objective To explore the application effect of Nd:YAG laser in single root canal combined with Vitapex paste treating periapical cysts.Methods A total of 100 patients(100 teeth)with periapical cysts from January 2016 to June 2019 treated by single root canal in Huaxia Stomatological Hospital of Suzhou City were selected as the research objects.According to the random number table method,the selected patients were divided into the control group and the observation group,50 cases in each group.The control group was treated with single root canal combined with Vitapex paste,while the observation group was treated with Nd:YAG laser irradiation on the basis of the control group.The clinical symptom scores before and after treatment,therapeutic effect and incidence of adverse reactions in the two groups were compared.Results The total effective rate of treatment in the observation group was 98.00%,which was higher than 84.00%in the control group,the difference was statistically significant(P<0.05).There was no significant difference in themastication score between the two groups before treatment(P>0.05).Themastication scores of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).After treatment,themastication score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant adverse reaction occurring during the treatment period in both groups.Conclusion The application effect of Nd:YAG laser in single root canal combined with Vitapex paste treating periapical cysts is remarkable and worthy of clinical promotion.
2020 Vol. 27 (9): 95-97 [Abstract] ( 75 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
98 Clinical effect com parison of surgical treatment for patients with congenital preauricular fistula in infected and non-infected period
WANG Xiao-feng; LI Jia; ZHANG Zhi-xiong; LI Xiong-wen; YE Yuan-hang
Objective To compare the clinical effect of surgical treatment for patients with congenital preauricular fistula during infected and non-infected period.Methods Patients with congenital anterior fistula in infected period admitted to our hospital from January 2016 to December 2018 were enrolled as the observation group(n=35),and patients in non-infected period admitted at the corresponding time were selected as the reference group(n=35).Both groups of patients were treated with appropriate surgicalmethods according to their lesion situation.The postoperative healing of the surgical treatment between the two groupswas compared.The patients′satisfaction with the postoperative appearance was investigated.The postoperative infection and recurrence of the two groups were followed up.Results There were no significant differences between the two groups in the first-stage healing rate,the second-stage healing rate(P>0.05).There was no significant difference between the two groups in satisfaction in appearance(P>0.05).There were no significant differences between the two groups in postoperative infection rate and recurrence rate during 6-month follow up visits(P>0.05).Conclusion Surgical treatment of congenital preauricular fistula patients during infection period is similar to surgical treatment during non-infeced period in therapeutic effect and satisfaction in appearance.Therefore,patients can undergo surgical treatment before the resolution of infection,which can shorten the course and alleviate pain,and is worthy of further study.
2020 Vol. 27 (9): 98-100 [Abstract] ( 84 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
101 Application of cone beam computer tomography in the morphological in the measurement of alveolar bone morphology in patients with Class Ⅱ and Class Ⅲ high angle malocclusion
YAN Jun; ZHAO Run-cheng; LI Li-na
Objective To investigate the application effect of cone beam computer tomography(CBCT)in the morphological difference of alveolar bone in lower incisors of patients with Class Ⅱ and Class Ⅲ high angle malocclusion.Methods From January 2018 to March 2019,80 patients with Class Ⅱ and Class Ⅲ high angle malocclusion treated in the Department of Stomatology in Taishan People′s Hospital were selected as the subjects.The height and thickness of alveolar bone in the lower incisor area of two kinds of high angle malocclusion patients were measured.Results There were no significant differences in alveolar bone height between Class Ⅱ and Class Ⅲ high angle malocclusion patients(P>0.05).There were no significant differences in the thickness of 2,4,6mm under CEJbetween the Class Ⅱ and Class Ⅲ high angle malocclusion patients(P>0.05).The thickness of alveolar bone at2,4,6mm under the lingual CEJand at the root tip of the lingual side of the patients with skeletal Class Ⅲ was smaller than that of the patients with skeletal Class Ⅱ,and the differences were statistically significant(P<0.05).Conclusion The alveolar bone thickness in the lateral apical area of the lower incisor in the patients with Class Ⅲ high angle malocclusion is thinner and narrow than that in the patients with Class Ⅱ high angle malocclusion.Special attention should be paid to the control of torque when moving the lip and tongue of the anterior teeth in order to prevent the occurrence of root resorption,bone fenestration,bone cracking and so on.
2020 Vol. 27 (9): 101-103 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 4 )
104 Effect of Dizocine combined with Propofol on postoperative analgesia and agitation during recovery period in patients undergoing general anesthesia
LI Xiao-li
Objective To explore the effect of Dizocine combined with Propofol on postoperative analgesia and agitation during recovery in patients undergoing general anesthesia.Methods A total of 60 patients undergoing general anesthesia in our hospital from January 2017 to January 2019 were selected for study.According to the random number table method,they were divided into control group and study group,with 30 cases in each group.The control group received intravenous Fentanyl 0.6 g/kg+Propofol 1 mg/kg,and the study group received intravenous Propofol 1 mg/kg+Dizocine 0.15 mg/kg.The pain scores of the two groups from postoperative to conscious time(T1)and 20 min after catheter removal(T2),restlessness and incidence of adverse reactions during recovery were compared.Results During T2,the pain score of patients in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The pain scores of the two groups at T2 were lower than those at T1,and the differences were statistically significant(P<0.05).The agitation rate of patients in the study group(6.67%)was lower than that of patients in the control group(46.67%),and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the awakening period in the study group(6.67%)was lower than that in the control group(36.67%),and the difference was statistically significant(P<0.05).Conclusion The use of Dizocine combined with Propofol in patients undergoing general anesthesia can significantly reduce postoperative pain and agitation,and it also can effectively reduce the incidence of adverse reactions,which is worthy of extensive use in clinical practice.
2020 Vol. 27 (9): 104-106 [Abstract] ( 68 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
107 Application effect of intravenous Dexmedetom idine on postoperative emergence agitation in the children with total intravenous anesthesia
CAO Li-qun; WANG Jin-fei; DU Hua-juan; GONG Li-na
Objective To observe the effect of Dexmedetomidine on postoperative emergence agitation in the children undergoing tonsillectomy and adenoidectomy with total intravenous anesthesia.Methods Sixty children with total intravenous anesthesia who underwent tonsillectomy and adenoidectomy in Mentougou District Hospital from February 2014 to February 2016 were selected as the research objects.They were divided into Dexmedetomidine group(n=30)and control group(n=30)according to the random number table method.Patients in the Dexmedetomidine group received intravenous Dexmedetomidine 0.5μg/(kg·h),and patients in the control group received saline.The anesthesia time and recovery time of the two groups were recorded.The scores of children′s and infants′postoperative pain scale(CHIPPS)and pediatric anesthesia emergence delirium scale(PAED)were compared between the two groups at the time of recovery and 15,30min after recovery.At the same time,the incidence of nausea and vomiting was observed and compared between the two groups.The incidence rates of CHIPPS score>3 points and PAED score>12 points were recorded between the two groups.Results The CHIPPS scores of children in Dexmedetomidine group at the time of recovery and 15,30 min after recovery were lower than those in the control group,and the differences were statistically significant(P<0.05).The PEAD scores of children in Dexmedetomidine group at the time of recovery and 15,30min after recovery were lower than those of the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences between the two groups in the time of anesthesia,the incidence of nausea and vomiting during awaking,the incidence of CHIPPS score>3 points and the incidence of PAED score>12 points(P>0.05).The recovery time of Dexmedetomidine group was longer than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine can decrease the postoperative emergence agitation in the children undergoing tonsillectomy and adenoidectomy with total intravenous anesthesia.
2020 Vol. 27 (9): 107-110 [Abstract] ( 75 ) HTML (40 KB)  PDF  (0 KB)  ( 10 )
111 Application value of multi-slice spiral CT enhanced scan in the diagnosis of gastrointestinal vascular malformation
LI Yi-liang; ZHANG Chun-xia; LI Yong; ZENG Qing-le
Objective To study the application value of multi-slice spiral CT enhanced scan in the diagnosis of gastrointestinal vascular malformation.Methods A total of 60 patients suspected with gastrointestinal vascular malformation treated in Baiyun District Hospital of Traditional Chinese Medicine,Guangzhou City from June 2017 to September 2018 were selected as research objects.Themulti-slice spiral CT enhanced scan and digital subtraction angiography were performed,and the digital subtraction angiography examination resultswere taken as golden standard.The clinical manifestations as well as diagnosis sensitivity,specificity and accordance rate ofmulti-slice spiral CT enhanced scan were recorded and counted.The display rate of gastrointestinal vascular malformation in the feeding artery,draining vein and arterio-venous fistula based on CT was analyzed.Results Through multi-slice spiral CT enhanced scan examination,32 patients were confirmed with gastrointestinal vascular malformation.At arterial phase,CT enhanced scan showed obviously strengthened strip,nodular or flake-shaped tortuous lesions or irregular vascular anomaly.At portal venous phase and equilibrium phase,the enhanced degree was substantially declined with thickened blood vesselwall while no obvious stenosis appeared in lumen.The diagnosis sensitivity,specificity and accordance rate based onmultislice spiral CT enhanced scan(96.86%,96.43%,96.67%)and digital subtraction angiography(100.00%,100.00%,100.00%)showed no statistically significant differences(P>0.05).The display rate of gastrointestinal vascular malformation in the feeding artery and arterio-venous fistula based onmulti-slice spiral CT enhanced scan(96.88%,75.00%)and digital subtraction angiography(100.00%,81.25%)showed no statistically significant differences(P>0.05).The display rate of gastrointestinal vascular malformation in the draining vein based onmulti-slice spiral CT enhanced scan(68.75%)was lower than that of digital subtraction angiography(100.00%),with statistically significant difference(P<0.05).Conclusion Based onmulti-slice spiral CT enhanced scan,the position,range and morphology of gastrointestinal vascular malformation can be clearly and accurately displayed.Owing to its high diagnosis sensitivity,specificity and accordance rate,multi-slice spiral CT enhanced scanmay be served as themajormethod for screening of gastrointestinal vascular malformation.
2020 Vol. 27 (9): 111-114 [Abstract] ( 65 ) HTML (39 KB)  PDF  (0 KB)  ( 9 )
115 Influence of different degrees of pulmonary arterial hypertension on the treatmenteffect of ultrasound-guided pericardialeffusion catheter drainage
LI Ling
Objective To investigate the influence of different degrees of pulmonary arterial hypertension on the treatment effect of ultrasound-guided pericardial effusion catheter drainage.Methods A total of 74 patients with pulmonary arterial hypertension and pericardial effusion admitted to our hospital from June 2015 to December 2017 were selected as research objects,and they were divided into three groups according to the classification of pulmonary arterial hypertension,namely themild group(30-<50mmHg)(33 cases),moderate group(50-70mmHg)(24 cases)and severe group(>70mmHg)(17 cases).The pulse pressure,heart rate,left and right diameter of right atrium,inferior caval vein diameter,and tricuspid annular plane systolic displacement before and after operation were compared among the three groups.The cure rate of the three groups of patients was recorded.Results Before operation,there were no significant differences in pulse pressure,heart rate,left and right diameter of right atrium,inferior caval vein diameter,and tricuspid annular plane systolic displacement among the three groups(P>0.05).Compared with before operation,the pulse pressure,heart rate,left and right diameter of right atrium,inferior caval vein diameter,and tricuspid annular plane systolic displacement at 1 d after operation in the three groups all improved,and the improvement of themild group was greater than that of themoderate group and severe group,and the improvement of themoderate group was greater than that of the severe group,with statistically significant differences(P<0.05).There was no significant difference in the cure rate between themild group and themoderate group(P>0.05).The cure rate of patients in themild group and themoderate group was higher than that in the severe group,and the difference was statistically significant(P<0.05).Conclusion Ultrasound-guided pericardial effusion catheter drainage in the treatment of patients with mild pulmonary arterial hypertension combined with pericardial effusion has significant effect,it can optimize pulse pressure,heart rate,left and right diameter of right atrium,inferior caval vein diameter,and tricuspid annular plane systolic displacement.However,in the treatment of severe pulmonary arterial hypertension patients,the effect is not obvious.Therefore,in clinical application,treatment should be implemented according to the actual situations of the patients.
2020 Vol. 27 (9): 115-117转121 [Abstract] ( 70 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
118 Diagnostic value of combined dual-frequency ultrasound for pediatric intussusception
KE Hai-rong
Objective To study the diagnostic value of combined dual-frequency ultrasound for pediatric intussusception.Methods Retrospective analysis of routine ultrasound and combined dual-frequency ultrasound data of 88 children suspected with intussusceptions treated in our hospital from January 2018 to June 2019 was conducted,with realtimemonitoring of saline enema and surgical results as the golden criterion.The diagnostic results and diagnostic efficacy of conventional ultrasound and combined dual-frequency ultrasound were compared.The diagnosis results and detection rates of different types and lesions were compared between the two diagnostic methods.Results The accuracy and sensitivity of combined dual-frequency ultrasound diagnosis in children with intussusception were higher than those of conventional ultrasound,the differences were statistically(P<0.05).The detection rates between conventional ultrasound and combined dual-frequency ultrasound for different types and lesions had no significant difference(P>0.05).Conclusion Combined dual-frequency ultrasound is of important application value in the diagnosis of pediatric intussusception with high diagnostic accuracy and sensitivity,provides ensurance for early diagnosis and treatment of pediatric intussusception and can bewidely used in clinical diagnosis.
2020 Vol. 27 (9): 118-121 [Abstract] ( 74 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
122 Clinical application of nuclear medicine imaging and Dopp ler ultrasound diagnosis in subacute thyroiditis
NIAN Di WU Tong
Objective To investigate clinical application of nuclearmedicine imaging and Doppler ultrasound diagnosis in subacute thyroiditis.Methods A total of 133 patients with subacute thyroiditis and 133 patients without subacute thyroiditis treated in hospital from October 2011 to December 2013 were selected,who performed nuclear medicine imaging diagnosis and Doppler ultrasound diagnosis.The results of fine needle aspiration cytology were used as reference.The clinical diagnostic value(sensitivity,specificity,accuracy,positive predictive value)of nuclearmedicine imaging diagnostic examination,Doppler ultrasound diagnostic examination and combined diagnostic examination were analyzed.Results The sensitivity(80.5%),specificity(83.5%)and accuracy(82.0%)of nuclearmedical imaging diagnostic examination were higher than those of Doppler ultrasound diagnostic examination(69.2%,71.4%and 70.3%),the sensitivity(98.5%),specificity(97.7%)and accuracy(98.1%)of the combined diagnostic examination were all higher than those of nuclearmedical imaging diagnostic examination and Doppler ultrasound diagnostic examination,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the positive predictive value of Doppler ultrasound diagnostic examination,nuclearmedicine imaging diagnostic examination and combined diagnostic examination(P>0.05).Conclusion Nuclearmedicine imaging diagnosis and Doppler ultrasound diagnosis are effectivemethods in diagnosis of subacute thyroiditis.Combined diagnosis can improve diagnostic rate of diseases.
2020 Vol. 27 (9): 122-125 [Abstract] ( 77 ) HTML (38 KB)  PDF  (0 KB)  ( 10 )
126 Clinical effect of acupuncture combined with Chinese herbal medicine in the treatment of ovulatory disorder infertility
MA Wen-jun; CUI Shao-yang; NING Yan; CHEN Peng-dian
Objective To explore the clinical effect of acupuncture combined with Chinese herbal medicine in the treatment of ovulatory disorder infertility.Methods A total of 96 with ovulatory disorder infertility treated in Shenzhen Hospital of Guangzhou University of Chinese Medicine from June 2016 to October 2017 were enrolled.They were divided into treatment group and control group according to random number table method,48 cases in each group.In the control group,oral administration of Chinese herbalmedicine Laishi Yiyun Formula combined with intramuscular injection of Human Chorionic Gonadotropin(HCG)were used.In the treatment group,on the basis of the control group,Tongyuan acupuncture was added.The clinical efficacy,cervical mucus score,endometrial type A rate,endometrial spiral artery pulsatility index(PI)and resistance index(RI)were compared between the two groups.Results There was no significant difference in ovulation rate between the two groups(P>0.05).The pregnancy rate in the treatment group was 70.8%,which was significantly higher than thatof the control group accounting for 43.8%with statistical difference(P<0.01).The cervicalmucus score and endometrial A rate in the treatment group were higher than those in the control group,and the endometrial spiral artery PIand RIwere lower than those in the control group,and the differences were statistically significant(P<0.01).Conclusion The combination of acupuncture and Chinese herbalmedicine can significantly enhance the ovulation-promoting effect on ovulatory disorder infertility,improve its cervicalmucus score and endometrial receptivity,regulate its reproductive endocrine function,and increase its pregnancy rate.Its effect is better than Chinese herbal intervention alone,which is worthy of clinical promotion and application.
2020 Vol. 27 (9): 126-128 [Abstract] ( 70 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
129 Effect of Huayu Ruanjian Decoction combined with Entecavir in the treatment of liver fibrosis in patients with chronic hepatitis B
ZHANG Yi-ling

Objective To investigate the effect of Huayu Ruanjian Decoction combined with Entecavir in the treatment of chronic hepatitis B liver fibrosis.Methods Eighty-four patients with chronic hepatitis B liver fibrosis admitted to our hospital from February 2017 to February 2018 were selected and divided into control group and experimental group according to random number table method,42 cases in each group.The control group was treated with Entecavir,the experimental group was given Huayu Ruanjian Decoction combined with Entecavir.The improvement of liver function and liver fibrosis in the two groups before and after treatmentwere observed,and the safety of clinical treatmentwas evaluated.Results The levels of aspartate amino transferase(AST),alanine aminotransferase(ALT),γ-glutamyl transpeptidase(GGT),total bilirubin(TBil)in the experimental group were(47.89±22.62),(44.23±14.80),(71.25±26.15)U/L,(41.07±6.51)μmol/L,whichwere lower than thoseof the controlgroup for(72.34±26.27),(57.12±18.19),(90.74±29.48)U/L,(49.12±7.86)μmol/L,the differences were statistically significant(P<0.05).The levels of typeⅢprocollagen(PCⅢ),typeⅣcollagen(Ⅳ-C),laminin(LN),hyaluronidase(HA)in the experimental group were(94.75±12.02),(75.60±8.93),(91.43±10.84),(83.34±9.36)μg/L,which were lower than those of the control group for(107.49±15.84),(89.26±9.35),(115.72±11.09),(95.53±11.87)μg/L,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the experimental group was higher than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion Huayu Ruanjian Decoction combined with Entecavir in the treatment of chronic hepatitis B liver fibrosis has a significant effect,high safety,can improve liver function and inhibit liver fibrosis.

2020 Vol. 27 (9): 129-131 [Abstract] ( 69 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
132 Clinical effect of Yiqi Wenyang Decoction combined with Western medicine treating chronic heart failure with partial hypotension
LI Lin; FAN Zhao-long
Objective To explore the clinical effect of Yiqi Wenyang Decoction combined with Westernmedicine treating chronic heart failure(CHF)with partial hypotension.Methods A total of 68 cases of CHF with partial hypotension admitted to our hospital from February 2018 to January 2019 were selected as the research objects.According to the random number table method,they were divided into control group(n=34)and observation group(n=34).The control group was treated with Western medicine,while the observation group was treated with Yiqi Wenyang Decoction combined with Western medicine.The cardiac function index,heart rate,blood pressure and clinical efficacy were compared between the two groups.Results After treatment,the left ventricular end-diastolic volume(LVEDV),left ventricular end diastolic diameter(LVEDD)and heart rate of the patients in the observation group were lower than those in the control group,and the left ventricular ejection fraction(LVEF),diastolic blood pressure and systolic blood pressure were higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the patients in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion YiqiWenyang Decoction combined with Western medicine can improve the clinical efficacy and cardiac function of patients with CHF and partial hypotension.It can slow down heart rate and control blood pressure levelwithin normal range.It has high clinical application value.
2020 Vol. 27 (9): 132-134转148 [Abstract] ( 56 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
135 Diagnostic value of human papillomavirus typing and Cervista detection in cervical intraepithelial neoplasia
FAN Ju-hua; QIN Yan; SONG Chun-lin
Objective To compare the diagnostic value of two methods of human papillomavirus(HPV)typing and Cervista detection in cervical intraepithelial neoplasia(CIN).Methods A total of 106 women with CIN1 and 210 women with CIN2+diagnosed by new baishi liquid-based cytology(TCT)and confirmed by cervical biopsy in our hospital from January 2017 to December 2018 were enrolled in this study.All participants underwent HPV typing and Cervista testing simultaneously.Then the diagnostic effect of the two tests was compared.Results The overall coincidence rate of the two HPV testing methods was 87.34%(276/316),and the KIvalue was 0.6377.The positive rate of HPV typing in CIN1 group was 51.88%,which was higher than that of Cervista testing(33.96%),the difference was statistically significant(P<0.05),but there was no significant difference between the twomethods in the CIN2+group(P>0.05).Conclusion The two methods are in good consistency and have equivalent diagnostic value in cervical cancer screening.HPV typing test has a higher positive rate in CIN1.
2020 Vol. 27 (9): 135-137 [Abstract] ( 63 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
138 Difference analysis of preoperative gastroscopy biopsy and postoperative pathological diagnosis of gastric cancer
WAN Xia ; CHEN Ping
Objective To explore the application value of gastroscopic biopsy and postoperative pathology in the diagnosisof gastric cancer. Methods Sixty patients with gastric cancer who were treated in our hospital from March 2017 toMarch 2019 were selected as the study subjects. All patients were diagnosed by postoperative pathology and underwentgastroscopy before surgery. The diagnosis of gastroscopic biopsy and postoperative pathology was performed. The accuracy,the pathological type of gastric cancer and the diagnosis of gastric cancer differentiation were compared and analyzed.Results The diagnostic coincidence rate of postoperative pathology in the diagnosis of gastric cancer reached 100.00%,and the diagnostic coincidence rate of preoperative gastroscopy biopsy in the diagnosis of gastric cancer was 86.67%(52/60), the difference was statistically significant (P<0.05). In the diagnosis of different pathological types, there were significantdifferences in the detection rate of preoperative gastroscopy biopsy and postoperative pathology in tubular adenocarcinoma,mucinous adenocarcinoma, papillary adenocarcinoma, signet ring cell carcinoma (P<0.05). The detection rateof preoperative gastroscopy biopsy on the differentiation type was lower than the postoperative pathology, and the differencewas statistically significant (P<0.05). Conclusion In the clinical diagnosis of gastric cancer, gastroscopy biopsycan provide a certain reference for the diagnosis of diseases, but the reference value is limited and can be used for theprevention and diagnosis of early gastric cancer. In order to make a definite diagnosis of the disease, it is still necessaryto synthesize the surgical pathology, combine the postoperative pathology results with the gastroscope biopsy results,reduce the incidence of misdiagnosis and missed diagnosis to the greatest extent, improve the accuracy of early diagnosisof gastric cancer, and make timely treatment plans, thus improving the quality of life of gastric cancer patients.
2020 Vol. 27 (9): 138-140 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
141 Effect of Group B Streptococcal infection on vaginal cleanliness and adverse pregnancy outcome in late pregnant women
MAO Xiao-ping; ZHU Shi-ming; LIU Quan
Objective To investigate the effect of Group B Streptococcus(GBS)infection on vaginal cleanliness and adverse pregnancy outcome in late pregnant women.Methods A total of 1240 pregnant women who were pregnant for more than 35 weeks in the obstetric examination of Tanbei Hospital in Zhongshan City,Guangdong Province from January 2016 to January 2018 were selected as subjects.All pregnant women were tested for vaginal cleanliness and vaginal secretions GBS,after which all pregnant women gave birth in our hospital.According to the results of pre-pregnancy vaginal secretion GBS culture,the pregnant women were divided into positive group(n=100)and negative group(n=1140).The maternal vaginal cleanliness and adverse pregnancy outcomes were compared between the two groups.The maternal vaginal cleanliness and pregnancy outcomes were compared between the two groups.Results The vaginal cleanliness abnormal rate of the positive group was 62.00%(62/100),which was higher than that of the negative group(34.91%[398/1140]),the difference was statistically significant(χ2=28.908,P<0.01).The incidence rates of premature rupture of membranes,premature delivery,puerperal infection,intrauterine distress and neonatal infection in the positive group were higher than those in the negative group,the differences were statistically significant(P<0.05).Conclusion GBS infection can lead to the decline of vaginal cleanliness in late maternal women,and may even induce adverse pregnancy outcomes.Therefore,GBS should be strengthened in the third trimester of pregnancy.
2020 Vol. 27 (9): 141-144 [Abstract] ( 76 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
144 Comparison of different characteristics of respiratory system SCIE literature in China,the United States,Britain,and Japan in the past three years
ZHANG Xin-feng; HUANG Jun-yao; CHEN Liang-hua; ZHANG Yi; LIU Yu-ping
Objective To explore the research status of China′s respiratory system research status and the gap with advanced countries in the world.Methods Using bibliometric method,based on the Web of Science′s literature data in the field of respiratory system from 2016 to 2018,a comparative analysis was conducted with the United States,Britain,Canada,and Japan,which ranked first in terms of the number of publications.The number of publications,the year of publication,the type of literature,the subject category,and the influence of science and technology were discussed.Results The development trend of respiratory system research in all countries had converged in the past 3 years.Meeting abstracts and articles accounted for 81%of the entire respiratory system literature.Among the five countries,the United States,Canada,and Japan had a relatively even distribution of document types,literature in the Britain was mainly the review,and China was the article.There were 331 high-cited articles in the field of respiratory system,211 in the United States accounting for 64%of the total,123 in the Britain accounting for 37%,27 in China accounting for 8%,84 in Canada accounting for 25%,and 31 in Japan accounting for 9%.Among the subject categories,Critical Care Medicine in the United States accounted for 75%of the world total,Oncology in China accounted for 24%,Japan and Britain accounted for 17%and 14%respectively,and Surgery in Japan accounted for 10%.Conclusion The number of research articles on respiratory system in China has steadily increased,some high-impact articles have been produced,but the ratio to the number of articles is relatively low,and the type of literature is relatively monotonous.The research categories of Oncology is relatively prominent,occupying a certain share in the world.
2020 Vol. 27 (9): 144-148 [Abstract] ( 69 ) HTML (37 KB)  PDF  (0 KB)  ( 12 )
149 Investigation and interventionable risk factors analysis of protein energy wasting status in maintenance hemodialysis patients by patient-generated subjective global assessment
CHEN Xue-xun; ZHU Zi-hao; LIU Zhi-min; ZHANG Cheng-yin; ZHANG Hai-bo; ZHAO Xue-lan; Xu Hui-yin; LI Xuan; CAO Bo; CHAI Chun-xiang; GUO min; WU Wen-bin
Objective To investigate the protein energy wasting(PEW)status of patients with maintenance hemodialysis(MHD)by patient-generated subjective global assessment(PG-SGA)and analyze the interventionable risk factors.Methods From September to December 2018,432 patients with MHD were selected as research objects from four dialysis centers of Affiliated Hospital of Weifang Medical University,Weifang Yidu Central Hospital,Weicheng Economic Development Zone Hospital,People′s Hospital of Xiashan Ecological and Economic Development Zone of Weifang City.A cross-sectional study was conducted.The PG-SGA combined with questionnaires,anthropometry and biochemical indicators were used to evaluate PEW status and analyze influencing factors in MHD patients.Results The total incidence rate of PEW in 432 patients with MHD was 52.78%.The total incidence rates of PEW in patients with diabetes,acidosis,inadequate dialysis Kt/V<1.2,age≥65 years,and dialysis time≥5 years were higher than those in non-diabetes,non-acidosis,adequate dialysis,age<65 years,and dialysis time<5 years patients,the differences were statistically significant(P<0.05).In different PG-SGA qualitative evaluation,individual nutritional indicators such as bodymass index(BMI),upper arm midpoint circumference(MAC),triceps skin fold thickness(TSF),upper arm muscle circumference(MAMC),albumin(ALB),and hemoglobin(Hb),PG-SGA C was lower than PG-SGA A and PG-SGA B,and PG-SGA B was lower than PG-SGA A,with statistically significant differences(P<0.05).Logistic multivariate analysis showed that diabetes(OR=3.01,95%CI:1.52-5.84),acidosis(OR=1.92,95%CI:1.13-3.34),inadequate dialysis Kt/V<1.2(OR=1.73,95%CI:1.05-3.68)were all interventionable risk factors for PEW in MHD patients(P<0.05).Conclusion The incidence of PEW is high in MHD patients,especially in patients with diabetes.Diabetes,acidosis and inadequate dialysis Kt/V<1.2 are interventionable risk factors for PEW in MHD patients.
2020 Vol. 27 (9): 149-152 [Abstract] ( 71 ) HTML (41 KB)  PDF  (0 KB)  ( 11 )
153 Effect of Williams life skills training intervention on the physical and mental health of nurses in operating room
ZOU Yan; WANG Hai-yan
Objective To investigate the influence of Williams life skills training intervention on the physical andmental health of nurses in operating room.Methods A total of 92 operating room nurses in our hospital from May 2016 to May 2018 were selected as subjects.According to the complete randomization,they were divided into the observation group(n=46)and control group(n=46).The observation group received Williams life skills training intervention model,and the control group received traditional intervention model.The scores of work stress,work environment,work time assignment,self-efficacy aswell as the total incidence of diseases between the two groups were compared.Results The scores of work stress,work environment and work time assignment in the observation group were lower than those in the control group after intervention,with statistical significances(P<0.05).The self-efficacy score of nurses in the observation group was higher than that of the control group after intervention,with statistical significance(P<0.05).The total incidence of disease of nurses in the observation group was lower than that in the control group,with statistical significance(P<0.05).Conclusion Williams life skills training intervention mode can effectively improve the self-efficacy of nurses in the operating room,reduce their work stress,and ensure their physical and mental health,which is worthy of promotion.
2020 Vol. 27 (9): 153-155 [Abstract] ( 83 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
156 Genotypic characteristics of thalassemia in our hospital
KONG Feng-zhen; WU Zan-kai; WEN Jia-min; LIU Hui
Objective To study the genotypic characteristics of thalassemia in our hospital. Methods From January2016 to June 2018, 1600 health examinees and prenatal examinees in our hospital were selected and analyzed for itemdata. The α thalassemia or β thalassemia types of all the examinees were determined by polymerase chain reaction andmembrane hybridization, and the statistical results were obtained. Results Among the 1600 subjects, the detection rateof thalassemia was 47.19%. The most common ones were α thalassemia with SEA heterozygosity deletion, β thalassemiawith 41-42 heterozygosity mutation, α thalassemia with 3.7 heterozygosity deletion, β thalassemia with 654 heterozygositymutation, β thalassemia with -28 heterozygosity mutation, 3.7 deletion combined with Southeast Asia type deletionof alpha thalassemia, 17-locus heterozygous mutation of beta-thalassemia and 4.2-locus heterozygous deletion ofalpha-thalassemia, 71-72 locus heterozygous mutation of β thalassemia. Conclusion In our hospital, the main type ofα thalassemia is sea heterozygous deletion, and the main type of β thalassemia is 41-42 heterozygosity mutation. It isnecessary to strengthen counseling and intervention management to control and reduce the situation of thalassemia.
2020 Vol. 27 (9): 156-158转162 [Abstract] ( 75 ) HTML (26 KB)  PDF  (0 KB)  ( 11 )
159 Current status of treatment for children with β-thalassem ia major in Zhuhai Municipal Maternity and Child Healthcare Hospital and reasons for non-standard treatment
DUAN Li; LI Tong; WANG Feng
Objective To investigate the non-standard treatments of children with β-thalasemiamajor(β-TM)and its causes,so as to reduce the proportion of non-standard treatments and improve the survival status of children.Methods A total of 57 cases of β-TM children treated in Zhuhai Municipal Maternity and Child Healthcare Hospital from January to December in 2018 were selected as the subjects,and the blood transfusion,iron removal,iron overload and the causes of non-standard treatment were investigated.Results Among the 57 children with β-TM,there were 13 children(22.8%)with irregular blood transfusion and 17 children(34.0%)with non-normative iron removal.Among the 57 children with β-TM,the reasons for irregular blood transfusion were 10 cases(17.5%)of family financial difficulties,and 3 cases(5.3%)of parents′neglect.Among the 50 children who needed to use iron removing drugs,the causes of nonnormative iron removal were 11 cases(22.0%)of family financial difficulties,3 cases(6.0%)of side effects of drugs,and 3 cases(6.0%)of parents′neglect.There was no significant difference in serum ferritin(SF)between regular and irregular blood transfusion groups(P>0.05).The SF level in non-normative iron-removing group was higher than that in normative iron-removing group,and the difference was statistically significant(P<0.05).Conclusion The proportion of non-standard treatments of children withβ-TM is high,most of which are related to economic difficulties.Increasing the income of medical insurance forminors will help to reduce the proportion of non-standard treatments and improve the prognosis of children with β-TM.
2020 Vol. 27 (9): 159-162 [Abstract] ( 88 ) HTML (34 KB)  PDF  (0 KB)  ( 10 )
163 Failure analysis and maintenance of Dongli TR-8000 hemodialysis machine
CHEN Xing
The usage of Dongli TR-8000 hemodialysis machine is summarized during the treatment process in department of dialysis of our hospital tomake the problems and failures that are easy to occur in this equipment and propose effective maintenance methods certain.The clear analysis of the malfunction of Dongli TR-8000 hemodialysis machine and applying maintenance method in a targeted way in this article,can make the equipment of Dongli TR-8000 hemodialysis machine be better applied in clinicalwork.
2020 Vol. 27 (9): 163-164转168 [Abstract] ( 84 ) HTML (25 KB)  PDF  (0 KB)  ( 10 )
165 Controlling of medical devices instructions
LI Bao-lin; LI Bo-cheng; ZHANG Fa-yong
It was analyzed and discussed for risk management,advanced notification and controlling on changes of warning,and found that it needs to put forward suggestions for improvement by discussing a living example of the instructions of an implantable medical devices but very different deciding on auditing on the basis of"Good Manufacturing Practice for Medical Devices".I twas necessary to refer warning on entries of the register for user to guide the correct operating or using in time,and pay good attention to the hazard notes in the instructions marked with the warning in order to ensure the quality and reduce using risk furthest.
2020 Vol. 27 (9): 165-168 [Abstract] ( 77 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
169 Application effect of micro-lesson combined with simulated operating room training mode teaching in operating room nursing students
LI Yu-chan
Objective To explore the application effect ofmicro-lesson combined with simulated operating room training mode teaching in operating room nursing students.Methods A total of 200 nursing students who came to our hospital from March 2016 to December 2018 were selected as subjects for retrospective analysis.They were divided into control group(n=100)and observation group(n=100)according to different teaching methods.In the control group,nursing students received the traditional clinical nursing teaching mode,and in the observation group,they received the micro-lesson combined with simulated operating room training mode.The theoretical and operational performance levels and total teaching satisfaction of the two groups of students were compared after 4 weeks.Results The theoretical score of the observation group was(80.93±5.14)points,higher than that of the control group([76.28±5.72]points)(P<0.05).The operation score of the observation group was(88.73±4.84)points,which was also higher than that of the control group([81.32±5.48]points)(P<0.05).In the observation group,the total teaching satisfaction was 96.00%,higher than that of the control group accounting for 81.00%(P<0.05).Conclusion Themicro-lesson combined with simulated operating room training mode nursing teaching can improve themastery of the theoretical knowledge and operational skills of nursing students,and also increase the satisfaction of nursing students on nursing teaching.
2020 Vol. 27 (9): 169-171 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
172 Application effect of"six-in-one"-teaching-mode in clinical teaching of gastroenterology
YAO Yu-xia; XU Bao-hong; GUO Ya-li; XIN Shen; SONG Li; KUAIDa-yu
Objective To explore the application effect of"six-in-one"-teaching-mode in clinical teaching of gastroenterology.Methods From September 2015 to June 2018,the five-year outer-suburbs directional-training undergraduates of Beijing Luhe Hospital,Capital Medical University were selected as research subjects for retrospective analysis.According to different teaching modes,they were divided into experimental group and control group,with 50 cases in each group."Six-in-one"-teaching-mode was applied in experimental group and traditional teaching mode was applied in control group.Their graduation test scores of the two groups were compared.Results The passing rate of medical examination,the result of inquiry,the result of physical examination,the writing of medical records,the interpretation of auxiliary results,the state of illness,the issuance of medical advice and the skill operation of the interns in experimental group were higher than those in control group,and the differences were statistically significant(P<0.05).Conclusion The application of"six-in-one"-teaching-mode in clinical teaching can stimulate learning initiative of students and improve their grades and clinical ability,which is expected to be further improved and promoted.
2020 Vol. 27 (9): 172-174转187 [Abstract] ( 74 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
175 Application effect of Conjugated Estrogen Cream combined with comprehensive nursing intervention on severe uterine prolapse before vaginal preparation
ZHANG Jie-fang
Objective To explore the application effect of vaginal preparation Conjugated Estrogen Cream combined with comprehensive nursing intervention on severe uterine prolapse before vaginal preparation.Methods A total of 98 cases of severe uterine prolapse treated in our hospital from January 2017 to December 2018 were selected and divided into control group and research group according to random number table method,49 cases in each group.The two groups were given Conjugated Estrogen Cream vaginal medicine,in which the control group received routine nursing intervention,while the research group received comprehensive nursing intervention.Psychological status,total nursing satisfaction and complications were compared between the two groups.Results The hospital anxiety and depression scale(HADS)score of the research group was(6.87±2.15)points,lower than that of the control group for(10.48±2.57)points,the difference was statistically significant(P<0.05).The total nursing satisfaction of the research group was 95.92%,higher than that of the control group for 81.63%,(P<0.05).The total incidence of complications in the research group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion The combination of Conjugated Estrogen Cream and comprehensive nursing can effectively improve the preoperative psychological state of patients with severe uterine prolapsed,improve nursing satisfaction,reduce postoperative complications and facilitate the recovery of patients.
2020 Vol. 27 (9): 175-177 [Abstract] ( 87 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
178 Application effect of evidence-based nursing in children with hand,foot and mouth disease
GAO Shi-qin; PAN Qing-xia; YANG Dong-xin; YAN Fei-fei
Objective To explore the application effect of evidence-based nursing in children with hand,foot and mouth disease(HFMD).Methods From September 2017 to September 2018,160 children with HFMD treated in our hospital were selected and divided into control group(n=80)and observation group(n=80)by the random digital table method.The children in the control group were given routine nursing,and the children in the observation group were given evidence-based nursing intervention on the basis of routine nursing.The symptom improvement time,compliance of nursing process and total nursing satisfaction were compared between two groups.Results The time of antirash,antipyretic,pharyngeal pain disappearance and appetite improvement in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).The compliance of behavior,exercise,diet and medication of the children in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The total nursing satisfaction of the family of the children in the observation group was 96.25%,which was higher than that of the control group(78.75%),and the differencewas statistically significant(P<0.05).Conclusion In the course of the treatment of HFMD,by evidence-based nursing intervention,the children compliance in the course of treatment can be improved,the treatment effect is guaranteed,the recovery of the child is promoted,and the nursing satisfaction of the children′s family is improved.
2020 Vol. 27 (9): 178-180 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
181 Application effect of evidence-based nursing concept in rehabilitation clinical teaching
ZHANG Qi; YAN Yin; WAN Li-qin; YIN Xiu-ling
Objective To study the application effect of evidence-based nursing concept in rehabilitation clinical teaching.Methods A total of 120 nursing interns entering the clinical rehabilitation department for internship from July 2015 to May 2017 were selected and divided into the control group(n=60)and the observation group(n=60)by blind selection.The control group used the traditional teaching method,while the observation group adopted rehabilitation clinical teaching and evidence-based nursing teaching methods.The theoretical scores,operation scores and clinical teaching satisfaction of the two groups of nursing interns,and the scores of the truth seeking,mind openness,analytical ability,systematic ability,self-confidence in critical thinking,curiosity and cognitivematurity and the total scores between the two groups were compared.Results The theoretical scores and operation scores of the nursing interns in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The total satisfaction of the observation group was 95.0%,higher than that in the control group accounting for 73.0%,the difference was statistically significant(P<0.05).The scores of the truth seeking,mind openness,analytical ability,systematic ability,self-confidence in critical thinking,curiosity and cognitivematurity and the total scores in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Through the combination of teaching mode and case teaching,application of the clinical teachingmethod of evidence-based nursing rehabilitation can improve the theoretical results,operation level and critical thinking ability of nursing interns,and patients′satisfaction with the nursing interns of evidence-based nursing,which lays a certain foundation for the establishmentof a harmonious relationship between nurses and patients.
2020 Vol. 27 (9): 181-183 [Abstract] ( 71 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
184 Application effect of clinical nursing pathway in very low birth weight infants
DENG Cui-li
Objective To investigate application effect of clinical nursing pathway in quality nursing service for very low birth weight infants(VLBW).Methods A total of 86 VLBW were selected in our hospital from October 2013 to October 2018,who were divided into control group and observation group by random number table method,43 cases in each group.The control group received traditional nursing service,the observation group received quality nursing service including clinical nursing pathway.Basic data(body weight,head circumference,height)in two groups were recorded at the time of delivery and nursing 2 weeks.Nursing effect,family satisfaction,adverse events were compared between two groups.Results The body weight of the observation group was higher than that of the control group at 2 weeks of nursing,head circumference was longer than that of the control group,height was higher than that of the control group,the differences were statistically significant(P<0.05).The daily milk intake and weight gain in observation group were more than that of the control group,the differences were statistically significant(P<0.05).The hospitalization time in observation group was shorter than that of the control group,the difference was statistically significant(P<0.05).Parents′cognition of neonatal nursing knowledge and parents′mastery of operational skills in observation group were higher than those of the control group,the differences were statistically significant(P<0.05).The total incidence of adverse events in observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion The application of clinical nursing pathway in quality nursing service can significantly improve nursing effect of VLBW,which is worthy of clinical application.
2020 Vol. 27 (9): 184-187 [Abstract] ( 53 ) HTML (36 KB)  PDF  (0 KB)  ( 16 )
188 Nursing effect of lower back muscle functional exercise and straight-leg raising training in patients with lumbar intervertebral disc herniation
ZHOU Li-yuan; ZHANG Yan; ZHU A-ling
Objective To investigate the application effect of lower back muscle functional exercise and straight-leg raising training in nursing of lumbar intervertebral disc herniation.Methods A total of 60 patients with lumbar intervertebral disc herniation in our hospital from February 2018 to January 2019 were selected as research subjects.They were divided into control group and observation group according to themethod of generating random number by computer program,30 cases in each group.The control group took routine nursing;the observation group added lower back muscle functional exercise and straight-leg raising training based on control group.After intervention,the postoperative recovery of lumbar function,pain degree,total nursing satisfaction,rehabilitation effect were compared between two groups.Results After intervention for 3months,the score of Japanese Orthopaedic Association(JOA),total nursing satisfaction,total effective rate of rehabilitation in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).After intervention for 1,2 weeks and 1month,the score of visual analogue scale(VAS)in observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Lower back muscle functional exercise and straight-leg raising training in nursing of lumbar intervertebral disc herniation can increase rehabilitation effect,promote recovery of lumbar function,relieve pain degree,increase nursing satisfaction,and have easy operation,significant efficacy and better safety,which is worthy of clinical promotion and application.
2020 Vol. 27 (9): 188-190转195 [Abstract] ( 67 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
191 Clinical value of intensive nursing combined with health education in patients with hypertension and cerebral infarction
CUI Tian; RONG Shuo-yan
Objective To investigate clinical value of intensive nursing combined with health education in patients with hypertension and cerebral infarction.Methods A total of 184 patients with hypertension and cerebral infarction were selected in hospital from May 2017 to May 2019were seleced as the subjects,whowere divided into controlgroup(92 patients)and observation group(92 patients)by random number table method.The control group received routine nursing,and the observation group received intensive nursing combined with health education.Clinical indexes and neurological deficit score,health knowledge score,self-care ability score,health behavior score,hospitalization time were compared between two groups.Results The diastolic blood pressure,systolic blood pressure and neurological deficit scores of the two groups after nursing were lower than those before nursing,and the differences were statistically significant(P<0.05).The health knowledge scores(daily life,diet,exercise,stroke risk factors,stroke management,stroke precursors,blood pressure control,medication),self-care ability scores(self-care skills,self responsibility,self-concept,health knowledge level),health behavior scores(health responsibility,nutrition,exercise,self realization,stress management,interpersonal relationship)in two groups after nursing were higher than those before nursing,the differences were statistically significant(P<0.05).The diastolic blood pressure,systolic blood pressure and neurological deficit score in observation group were lower than those in control group after nursing,the differences were statistically significant(P<0.05).The health knowledge scores(daily life,diet,exercise,stroke risk factors,stroke management,stroke precursors,blood pressure control,medication),self-care ability scores(self-care skills,self responsibility,self-concept,health knowledge level),health behavior scores(health responsibility,nutrition,exercise,self realization,stress management,interpersonal relationship)in observation group were higher than those in control group after nursing,the differences were statistically significant(P<0.05).The hospitalization time in observation group was shorter than that in control group after nursing,the difference was statistically significant(P<0.05).Conclusion Intensive nursing combined with health education can improve health knowledge level and self-care ability in patients with hypertension and cerebral infarction,which is worthy of clinical application.
2020 Vol. 27 (9): 191-195 [Abstract] ( 63 ) HTML (40 KB)  PDF  (0 KB)  ( 8 )
196 Application effect of health education mode based on health belief in acute myocardial infarction patients with interventional therapy
LI Li-ai
Objective To analyze the application effect of health education mode based on health belief in acute myocardial infarction(AMI)patients with interventional therapy.Methods The clinical data of 60 AMIpatients with interventional therapy in our hospital from November 2016 to September 2018 were retrospectively analyzed.All 30 patients with routine nursing from November 2016 to September 2017 were taken as control group,and on this basis,30 patients with health educationmode based on health belief from October 2017 to September 2018 were taken as observation group.The treatment compliance,health behavior,hospital stay,attack of angina pectoris,major adverse cardiac events were compared between the two groups.Results After discharge,the scores of health-promoting lifestyle profile Ⅱ(HPLP-Ⅱ)in observation group were higher than those in control group,the difference was statistically significant(P<0.05).The attack of angina pectoris in observation group was lower than that in control group,the difference was statistically significant(P<0.05).The total incidence of major adverse cardiac events in observation group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion Health education mode based on health belief in AMIpatients with interventional therapy can effectively improve health behavior,reduce the incidence of angina pectoris andmajor adverse cardiac events.
2020 Vol. 27 (9): 196-198转201 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
199 Application of evidence-based nursing in patients with myocardial infarction and heart failure
SU Xiao-hong; TAN Yong-jin
Objectiv e To explore the application of evidence-based nursing in patients with myocardial infarction(AMI)and heart failure.Methods Sixty patients with AMIand heart failure who were treated in our hospital from June 2014 to June 2016 were selected as the research subjects.The patients were divided into the control group(n=30)and observation group(n=30)according to the admission sequence of patients in the hospital.The control group received routine nursing,and the observation group received evidence-based nursing.The quality of life,rescue success rate,incidence of complication,and total nursing satisfaction were compared between the two groups.Results The rescue success rate in the observation group was 93.33%,higher than that of the control group accounting for 73.33%(P<0.05).The incidence of complications in the observation group was 6.67%,lower than that of the control group accounting for 26.67%(P<0.05).The scores of social function,material life,physical function and psychological function of the observation group after nursing were higher than those of the control group(P<0.05).The nursing total satisfaction of the observation group was 90.00%,higher than that of the control group for 73.33%,the difference was statistically significant(P<0.05).Conclusion The application of evidence-based nursing intervention in patients with AMI and heart failure is effective.It can increase the success rate of rescue,reduce the incidence of complications,and improve the quality of life aswell as the satisfaction of nursing,it can be popularized in clinical practice.
2020 Vol. 27 (9): 199-201 [Abstract] ( 73 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
202 Application effect of early rehabilitation nursing intervention in patients with hem iplegia
WANG Min
Objective To explore the application value of early rehabilitation nursing intervention in the nursing of patients with hemiplegia.Methods Ninety-six patients with hemiplegia admitted to our hospital from June 2015 to June 2017 were selected as the research objects.They were divided into control group(n=48)and observation group(n=48)according to different nursing methods.The control group was given routine nursing,and the observation group was provided with early rehabilitation nursing.The nursing satisfaction,psychological state,and motor and cognitive function before and after nursing of the two groups were compared.Results The total satisfaction of nursing in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the psychological state,motor,or cognitive function between the two groups before nursing(P>0.05).The self-rating anxiety scale(SAS)score and self-rating depression scale(SDS)scores of the observation group were lower than those of the control group,but the fugl-meyer(FMA)score and mini-mental state examination(MMSE)score of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion Early rehabilitation nursing intervention can promote the improvement of satisfaction of patients with hemiplegia,which is beneficial to the improvement ofmotor and cognitive function,and can also reduce the impact of adverse emotions.It is worthy of promotion and application.
2020 Vol. 27 (9): 202-204 [Abstract] ( 76 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
205 Effect of concept of rapid rehabilitation surgery on perioperative period of patients undergoing laparoscopic cholecystectom
LIU Xiao-qin; XIAO Hua-lan; OUYANG Yu-lian
Objective To explore the effect of rapid rehabilitation of surgical(FTS)concept in the perioperative period of patients with laparoscopic cholecystectomy(LC).Methods A total of 56 patients with LC in our hospital from April 2018 to April 2019 were selected as the subjects of study.According to the random number table method,they were divided into observation group(n=28)and the control group(n=28).The control group was given routine nursing,the observation group was given FTS concept.The clinical indexes,total incidence of complications and quality of life(QOL)score were compared between the two groups.Results The fasting time,exhaust time,bedtime and hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).The physiological function,material life,social function and psychological function scores of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion In perioperative period,the patients with LC are carried out the nursing work based on the FTS nursing concept,it can shorten fasting time,exhaust time,bed stay and stay,reduce the incidence of complications,is beneficial to the improvement of the quality of the patient′s life,it is worth popularizing.
2020 Vol. 27 (9): 205-207 [Abstract] ( 80 ) HTML (31 KB)  PDF  (0 KB)  ( 11 )
208 Effect of whole body rehabilitation massage on urinary retention in pregnant women
HUANG Hai-xiang; QIU Xi-jian; HUANG Yu-song; LI Xiao-lin; QUAN Qiu-yue
Objective To investigate the effect of whole body rehabilitation massage on urinary retention in pregnant women.Methods A total of 200 women who gave birth in our hospital from January to December 2018 were enrolled in the study.They were divided into control group and experimental group by random number table method,100 cases in each group.In the control group,the postpartum patients were given routine nursing management.On the basis of this,the experimental group added the whole body rehabilitation massage,the total incidence of maternal complications and urinary retention were compared between two groups.Results The incidence of dysuria in the experimental group was better than that in the control group,and the difference was statistically significant(P<0.05).The total incidence of complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Earlymaternal rehabilitation massage aftermaternal delivery can effectively prevent postpartum dysuria or urinary retention,and reduce the incidence of other complications,which is worthy of clinical application.
2020 Vol. 27 (9): 208-210 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
211 Application effect of layered nursing intervention in patients with hemodialysis
LI Qing-fu; ZUO Shao-mei
Objective To explore the effect of layered nursing intervention in hemodialysis(HD)patients.Methods A total of 60 HD patients treated in our hospital from June 2018 to June 2019 were selected as the study subjects,and were divided into control group and study group according to random number table method,30 cases in each group.The control group was given routine nursingmethod,while the study group was given layered nursing intervention.The clinical nursing satisfaction of two groups of HD patients,including self-rating anxity scale(SAS),self-rating depression scale(SDS)scores and post-nursing nursing quality score were compared between two groups.Results The total clinical nursing satisfaction of the patients in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in SAS and SDS scores between the two groups before nursing(P>0.05).The SASand SDS scores of the two groups after nursing were lower than those before nursing,the SAS and SDS scores of the patients in the study group were lower than those in the control group after nursing,the differences were statistically significant(P<0.05).The scores of basic nursing,professional skills,nursing safety,ward management and nursing documents in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion The application of layered nursing intervention in clinical nursing of HD patients is effective.
2020 Vol. 27 (9): 211-213 [Abstract] ( 72 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
214 Application effect of targeted health education in pregnant women with pregnancy com plications
GUI Lin-heng; XIONG Qiao-zhen
Objective To explore the application effect of targete health education in pregnant women with pregnancy complications.Methods Seventy-four pregnant women with complications admitted to Lushan People′s Hospital from February 2018 to June 2019 were selected as subjects of study.All caseswere divided into control group and observation group according to different nursingmethods,37 cases in each group.The control group was given routine nursing.Based on this,the observation group was given targeted health education.The Breast feeding awareness score,breastfeeding rate,total incidence of complications,and nursing satisfaction score were compared between two groups.Results The importance of breast feeding in the observation group,the scientific breast feeding method,the effect of breastmilk on the newborn,and the lactation scores were higher than that those of the control group,the differences were statistically significant(P<0.05);the breast feeding rate of the observation group was 81.1%,higher than that of the control group for 54.1%,the difference was statistically significant(P<0.05);the nursing satisfaction score of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion In thematernal nursing of pregnancy complications,the application of obstetric nursing staff to targete health education has positive significance for improving breast feeding awareness score and breast feeding rate,and it is worthy of clinical promotion.
2020 Vol. 27 (9): 214-216 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
217 Application of targeted nursing intervention in patients with gout
ZHAO Yang
Objective To explore the application of targeted nursing intervention in patients with gout.Methods Eighty gout patients admitted to our hospital from March 2018 to March 2019 were enrolled in the study.They were divided into observation group(n=40)and control group(n=40)by different nursingmethods.Routine nursing was used in the control group,and in the observation group,targeted nursing based on the specific conditionswas applied.The levels of blood uric acid and inflammatory factors after intervention were compared between the two groups.The changes of disease self-management ability after intervention were analyzed.Results The blood uric acid level in the observation group was lower than that before the intervention and in the control group,with statistical difference(P<0.05).The levels of interleukin-1(IL-1)and interleukin-6(IL-6)in the observation group were lower than those of the control group,with statistical differences(P<0.05).In the observation group,the scores of daily living self-care,symptomatic self-treatment,self-disposal on medication,psychological self-regulation and social interaction ability score after intervention were higher than those of the control group,with statistical differences(P<0.05).Conclusion Targeted nursing intervention for gout patients can effectively improve the self-management ability of the disease,reduce the levels of serum uric acid and inflammatory factors,and improve the clinical therapeutic effect.
2020 Vol. 27 (9): 217-219 [Abstract] ( 75 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
220 Effect of hierarchical nursing management in patients with ST-segment elevation myocardial infarction
BAI Yan-mei
Objective To explore the application effect of hierarchical nursing management in patients with ST-segment elevationmyocardial infarction(STEMI).Methods A total of 80 cases with STEMIadmitted to our hospital from April 2017 to June 2019 were selected as the research objects and divided into two groups according to the random number table method,40 cases in each group.The control group received routine responsibility system nursing,while the observation group received hierarchical nursing management intervention.The incidence of angina pectoris was compared.Echocardiography indexes,blood biochemical indexes and changes of New York heart function(NYHA)after the intervention were counted,and the disease self-management ability and quality of life scores of the two groups after the intervention were analyzed.Results During the intervention,the incidence of angina pectoris in the observation group was less than that in the control group,and the duration of angina pectoris in the observation group was also shorter than that in the control group,the differences were statistically significant(P<0.05).After the intervention,the left ventricular ejection fraction(LVEF)level in the echocardiogram index in the observation group was higher than that in the control group(P<0.05),the central atrial natriuretic peptide(BPN)level in the blood biochemical index was lower than that in the control group(P<0.05),and the NYHA rating was lower than that in the control group,the differences were statistically significant(P<0.05).After intervention,the disease self-management ability score in the observation group was higher than that in the control group(P<0.05),and the quality of life score was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion The implementation of hierarchical nursing management for acute STEMI can effectively improve the therapeutic effect,relieve the clinical symptoms of patients,improve cardiac function,improve cardiac ejection capacity and reducemyocardial injury,and is also of great significance for improving the disease-related knowledge of patients and improving the quality of life.
2020 Vol. 27 (9): 220-222转226 [Abstract] ( 68 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
223 Application effect of meticulous nursing in perioperative nursing of thyroidectomy patients
YU Na
Objective To explore the application effect ofmeticulous nursing in perioperative nursing of patients undergoing thyroidectomy.Methods A total of 90 patients with thyroidectomy in our hospital from January 2017 to January 2019 were selected and divided into control group and observation group according to the principle of randomized control,45 cases in each group.The control group received routine perioperative nursing,while the observation group received perioperative meticulous nursing.The self-rating anxiety scale(SAS),self-rating depression scale(SDS)scores before and after intervention,pain score,sleep quality score,nursing satisfaction score at discharge and complications were compared between the two groups.Results The SASand SDS scores of the patients in the observation group were lower than those in the control group(P<0.05);the pain score and sleep quality score of the patients in the observation group were lower than those in the control group on the first day after operation,and the nursing satisfaction score at dischargewas higher than that in the control group,the differences were statistically significant(P<0.05).The total incidence of postoperative complicationswas lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion Meticulous nursing can improve the anxiety and depression of patients with thyroid tumors,reduce the risk of pain and complications,and improve the quality of sleep,which is worthy of clinical recommendation.
2020 Vol. 27 (9): 223-226 [Abstract] ( 69 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
227 Clinical effect of Triamcinolone Acetonide in the treatment of keloid
DENG Le-ying; ZHU Yong-jun▲
Objective To explore clinicaleffect of Triamcinolone Acetonide in the treatment of keloid.Methods A total of 60 keloid patients treated in our hospital from July to December 2018 were selected.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was given local closure treatment with Prednisolone Acetate,while observation group was given local closure treatment with Triamcinolone Acetonide.The clinical effect,scar conditions before and after treatment,score of Vancouver scar scale(VSS),and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in observation group was higher than that in control group(93.33%vs.73.33%)(P<0.05).After treatment,thickness,width and length of scar in observation group were less than those in control group(P<0.05).At 1 and 2 months after treatment,VVS scores in observation group were smaller than those in control group(P<0.05).The total incidence of adverse reactions in observation group was lower than that in control group(3.33%vs.20.00%),the difference was statistically significant(P<0.05).Conclusion The curative effect of Triamcinolone Acetonide is significant effect on keloid,which can significantly improve thickness,width and length of scars,with high safety.
2020 Vol. 27 (9): 227-229转233 [Abstract] ( 74 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
230 Application effect of comfortable nursing in single-port laparoscopic gynecological surgery
ZHANG Zhi-wen; DENG Gui-juan; LI Yuan-feng
Objective To explore application effect of comfortable nursing in single-port laparoscopic gynecological surgery.Methods A total of 60 patientswho underwent single-port laparoscopic gynecological surgery in Shangrao Maternal and Child Health Hospital from January 2018 to April 2019 were enrolled.According to random number table method,they were divided into control group(n=30)and observation group(n=30).The control group was given routine nursing.On this basis,observation group was given comfortable nursing.Hemodynamic indexes,degree of anxiety and depression,score of visual analogue scale(VAS),and total incidence of postoperative complications were compared between the two groups.Results Before anesthesia,diastolic blood pressure,systolic blood pressure and heart rate of observation group were lower than those of control group(P<0.05).After nursing intervention,scores of anxiety and depression degree in observation group were lower than those in control group(P<0.05).At 3 and 7 d after surgery,VAS scores of observation group were lower than those of control group(P<0.05).The tatal incidence of postoperative complications in observation group was lower than that in control group(10.00%vs.33.33%),the difference was statistically significant(P<0.05).Conclusion The effect of single-port laparoscopic gynecological surgery combined with comfortable nursing is significant.It can not only regulate hemodynamic indexes of patients,but also reduce degree of anxiety and depression.
2020 Vol. 27 (9): 230-233 [Abstract] ( 73 ) HTML (38 KB)  PDF  (0 KB)  ( 16 )
234 Effect of collaborative nursing managementmodel on themastery of medical know ledge,psychology and quality of sleep in patients with hyperthyroidism
QI Li-na; WANG Chen-chen; JIANG Xue; QI Yan; HOU Li-hua
Objective To explore the effect of collaborative nursing management model on the mastery of medical knowledge,psychology and quality of sleep in patients with hyperthyroidism.Methods A total of 90 patients with hyperthyroidism who were treated in our hospital from May 2018 to April 2019 were selected as nursing management objects.The patients were divided into control group and observation group according to random number table method,52 cases in each group.The control group was given routine nursingmethod,the observation group was given collaborative nursing management for nursing intervention.After nursing,from the patients′medical knowledge,psychological situation and sleep were compared nursing effect.Results After nursing,the scores of medical knowledge governs in the observation group were higher than those in the control group,and the scores of psychological condition and quality of sleep were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The collaborative nursing managementmodel,effectively enriches themedical knowledge of patients with hyperthyroidism,improves psychological anxiety,depression and poor sleep quality and other problems,the effect is significant.
2020 Vol. 27 (9): 234-236转240 [Abstract] ( 72 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
237 Application effect of cluster nursing on patients with benign thyroid nodules treated bymicrowave ablation
GAN Ting; DENG Hui; SHI Xin-xin; HU Jin
Objective To investigate the application effect of cluster nursing on patients with benign thyroid nodules treated bymicrowave ablation.Methods According to the nursing program,a total of 115 patients with benign thyroid nodules treated by microwave ablation in Jiangxi Cancer Hospital from January 2018 to April 2019 were divided into control group(n=55)and observation group(n=60).Patients in the control group were nursed with routine nursing,while in the observation group,cluster nursing was added besides the routine nursing.The short-from 36 health survey scale(SF-36)scores,self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score,neck swelling incidence and other indicatorswere compared between the two groups.Results There were no significant differences in the scores of the SF-36 dimensions between the two groups at admission(P>0.05).On the 3rd postoperative day,the scores of body pain,energy,social function,emotional function and mental health of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in the scores of the three dimensions of scores of physiological functioning,physical role and general health status(P>0.05).The scores of the SF-36 on the 3rd postoperative day were lower than those at admission,the differences were statistically significant(P<0.05).There were no significant differences in SAS and SDS scores between the two groups at admission(P>0.05).On the 3rd day after operation,the SASand SDS scores of the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The SASand SDS scores of the 3rd day after operation were lower than those at admission,the differences were statistically significant(P<0.05).At 10 h after operation,the incidence of neck swelling in the observation group was lower than that in the control group,the differencewas statistically significant(P<0.05).Conclusion Cluster nursing is effective in patients with benign thyroid nodules treated bymicrowave ablation,which can improve the quality of life,improve anxiety and depression,and reduce the incidence of postoperative neck swelling.
2020 Vol. 27 (9): 237-240 [Abstract] ( 82 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
241 Application of specialist nursing quality index in common digestive diseases
HUANG Tuan-ai; HE Xiao-yun; OU Jian-ai; LI Jian-ling; XIE Xiao-xia
Objective To explore the application of specialist nursing quality index in common digestive diseases.Methods A total of 100 patients with esophageal and gastric varices bleeding,peptic ulcer bleeding and colorectal adenoma polyps in our hospital from February 2018 to February 2019 were enrolled in the study.All patients were divided into control group(50 cases)and observation group(50 cases)according to admission time.Patients in control group received routine nursing,while patients in observation group received specialist nursing quality index-oriented nursing measures on this basis.The data of specialist nursing quality indicators in two groups were compared and analyzed.Results After different strategies and nursing measures,the six dimensions of drug use accuracy,intestinal evaluation accuracy,enteroscopy nursing record accuracy,doctor-patient satisfaction,patients′knowledge of enteroscopy and the rate of achieving the standard of intestinal cleanliness under endoscopy in the observation group were higher than those in the control group,with statistical differences(P<0.05).Conclusion For patients with esophageal and gastric varices bleeding,peptic ulcer bleeding and colorectal adenoma polyps,the quality indicators of specialized nursing formulated and implemented is significant to improve the quality of nursing in digestive medicine and the prognosis of patients.
2020 Vol. 27 (9): 241-243 [Abstract] ( 72 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )
244 Effect of hydrocolloid dressing on controlling phlebitis in heart failure patients caused by Dobutamine intravenous injection
LI Yin
Objective To explore effect of hydrocolloid dressing on controlling phlebitis in heart failure(HF)patients caused by Dobutamine intravenous injection.Methods A total of 104 patients with HF who underwent Dobutamine intravenous injection in the hospital during the period from March 2018 to March 2019 were enrolled as study objects.According to different dressing after intravenous injection,they were divided into observation group(n=52)and control group(n=52).In control group,routine film was applied to fix indwelling needle.In observation group,addition to routine film fixation,10 cm hydrocolloid dressing was covered above puncture point of indwelling needle along vein going direction.The occurrence conditions of phlebitis were compared between the two groups.There were 15 cases with phlebitis in observation group,while 25 cases in control group.In terms of phlebitis patients,observation group was still treated with hydrocolloid dressing for external application,while control group was given routine treatment.The response rate of treatment,occurrence time,scores of visual analogue scale(VAS)before and after treatment were compared between the two groups.Results The phlebitis severity in observation group was lighter than that in control group(P<0.05).The response rate of treatment in observation group was higher than that in control group(P<0.05).The incidence of phlebitis occurrence time shorter than 4 h in observation group was lower than that in control group,while incidence of phlebitis occurrence time longer than 8 h was higher than that in control group(P<0.05).After treatment,VAS score of observation group was lower than that of control group(P<0.05).Conclusion In controlling phlebitis of HF patients caused by Dobutamine intravenous injection,the effect of hydrocolloid dressing is significant,which can decrease incidence of phlebitis,and prolong usage time of indwelling needle.
2020 Vol. 27 (9): 244-246转249 [Abstract] ( 75 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
247 Application effect of comprehensive nursing intervention in children with nephrotic syndrome
HUANG Guang-ling
Objective To investigate the effect of comprehensive nursing intervention in children with nephropathy syndrome(NS).Methods Fifty children with NS treated in our hospital from January 2017 to April 2019 were selected and divided into control group(n=25)and observation group(n=25)according to random number table method.The patients in the control group were given routine nursing and the patients in the observation group were given comprehensive nursing.The nursing effect and total satisfaction of the two groups were compared.Results The incidence of complications in the observation group was lower than that in the control group,the score of nursing quality was higher than that in the control group,and the awareness rate of health knowledge was higher than that in the control group,the differences were statistically significant(P<0.05).The total nursing satisfaction of the observation group was 96%,which was higher than that of the control group(76%),the difference was statistically significant(P<0.05).Conclusion The application of comprehensive nursing intervention in children with NS can reduce the incidence of complications,improve the nursing quality of nurses,the awareness rate of patients′health knowledge and nursing satisfaction,which is worthy of clinical application.
2020 Vol. 27 (9): 247-249 [Abstract] ( 66 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
250 Application effect of detail management in pediatric nursing management
TONG Jing-ping
Objective To explore the application effect of detail management in pediatric nursing management.Methods From January 2017 to December 2018,140 hospitalization children in our hospital were selected as the subjects.According to random number table method,they were divided into control group and observation group,70 cases in each group.Routine nursing management was performed in the control group,the observation group implemented detail management.The two groups of nursing adverse events,nursing disputes,nursing errors,complications and total nursing satisfaction were compared.Results The incidence of adverse events,nurse-patient disputes,complications and nursing errors in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The nursing total satisfaction of the family members in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion The detail management of nursing management in pediatrics makes the effect of nursing management prominent,nursing adverse events,nursing errors,the incidence of complications and nursing disputes significantly reduced.The satisfaction of family members to nursing has been improved,and detail nursing is an ideal way of pediatric nursing management,which is worth popularizing and applying in clinic.
2020 Vol. 27 (9): 250-252 [Abstract] ( 60 ) HTML (33 KB)  PDF  (0 KB)  ( 15 )
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