急性脑梗死中治疗性无症状出血转化的研究进展

Abstract
Figure/Table
References (36)
Related Citation (15)

Download: PDF (0 KB) HTML (44 KB)
Export: BibTeX | EndNote (RIS)

Abstract Asymptomatic intracranial hemorrhage is a common complication in acute cerebral infarction,which occurs more frequently in patients with reperfusion therapy.However,because it does not cause serious clinical consequences,it is often ignored.More and more clinical studies show that therapy-related asymptomatic intracranial hemorrhage is associated with slow recovery of neurological function and poor long-term prognosis.This article reviews the definition,pathogenesis,risk factors,predictionmethods,prognosis,prevention and treatment of therapy-related asymptomatic intracranial hemorrhage in acute ischemic stroke,aiming to provide a reference for clinicians to evaluate the risk of asymptomatic hemorrhage transformation in the treatment of acute cerebral infarction reperfusion.

Key words： Ischemic stroke Asymptomatic hemorrhage Outcome Intracranial hemorrhage Therapy-related

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SU Jie-hua
	REN Hui-jie
	ZENG Guan-wen
	LI Zhao-hui

Cite this article:

SU Jie-hua,REN Hui-jie,ZENG Guan-wen, et al. Research progress of therapy-related asymptomatic intracranial hemorrhage in acute ischem ic stroke[J]. 中国当代医药, 2020, 27(9): 28-32.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I9/28

[1]	Fiorelli M，Bastianello S，Von Kummer RD，et al.Hemorrhagic transformation within 36 hours of a cerebral infarct：relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I（ECASS I）cohort[J].Stroke，1999，30（11）：2280-2284.
[2]	Hao Y，Zhang Z，Zhang H，et al.Risk of intracranial hemorrhage after endovascular treatment for acute ischemic stroke：systematic review and Meta-analysis[J].Interv Neurol，2017，6（1-2）：57-64.
[3]	Katramados AM，Hacein-Bey L，Varelas PN.What to Look for on post-stroke neuroimaging[J].Neuroimaging Clin N Am，2018，28（4）：649-662.
[4]	England TJ，Bath PM，Sare GM，et al.Asymptomatic hemorrhagic transformation of infarction and its relationship with functional outcome and stroke subtype：assessment from the Tinzaparin in acute ischaemic stroke trial[J].Stroke，2010，41（12）：2834-2839.
[5]	Von Kummer R，Broderick JP，Campbell BC，et al.The heidelberg bleeding classification：classification of bleeding eventsafter ischemic strokeand reperfusion therapy[J].Stroke，2015，46（10）：2981-2986.
[6]	中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国急性脑梗死后出血转化诊治共识2019[J].中华神经科杂志，2019，52（4）：252-265.
[7]	Alvarez-Sabin J，Maisterra O，Santamarina E，et al.Factors influencing haemorrhagic transformation in ischaemic stroke[J].Lancet Neurol，2013，12（7）：689-705.
[8]	Paciaroni M，Agnelli G，Corea F，et al.Early hemorrhagic transformation of brain infarction：rate，predictive factors，and influence on clinical outcome：results of a prospective multicenter study[J].Stroke，2008，39（8）：2249-2256.
[9]	Hemorrhage in the interventional management of stroke study[J].Stroke，2006，37（3）：847-851.
[10]	Park JH，Ko Y，Kim WJ，et al.Is asymptomatic hemorrhagic transformation really innocuous?[J].Neurology，2012，78（6）：421-426.
[33]	陈艳超，雷春艳，刘鸣.脑梗死后出血转化不同亚型与预后关系的系统评价[J].中国卒中杂志，2015，10（10）：827-834.
[34]	中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志，2018，51（9）：666-682.
[35]	中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国脑出血诊治指南（2014）[J].中华神经科杂志，2015，48（6）：435-444.
[11]	Easton D，Donnan GA，Davis SM，et al.Prognosis of asymptomatic intracranial hemorrhage after endovascular treatment[J].Int JStroke，2019，11（2）：123-126.
[12]	Annan M，Gaudron M，Cottier JP，et al.Functional outcome of hemorrhagic transformation after thrombolysis for ischemic stroke：a prospective study[J].Cerebrovasc Dis Extra，2015，5（3）：103-106.
[13]	LeiC，Wu B，Liu M，etal.Asymptomatic hemorrhagic transformation after acute ischemic stroke：is it clinically innocuous?[J].JStrokeCerebrovasc Dis，2014，23（10）：2767-2772.
[14]	Kimura K，Iguchi Y，Shibazaki K，et al.Hemorrhagic transformation of ischemic brain tissue after t-PA thrombolysis as detected by MRImay be asymptomatic，but impair neurological recovery[J].JNeurol Sci，2008，272（1-2）：136-142.
[15]	Dzialowski I，Pexman JH，Barber PA，et al.Asymptomatic hemorrhage after thrombolysismay not be benign：prognosisby hemorrhage type in the Canadian alteplase for stroke effectiveness study registry[J].Stroke，2007，38（1）：75-79.
[16]	Libman R，Kwiakowski T，Lyden P，et al.Asymptomatic hemorrhagic transformation of cerebral infarction does not worsen long-term outcome[J].JStrokeCerebrovasc Dis，2005，14（2）：50-54.
[17]	Jickling GC，Liu D，Stamova B，et al.Hemorrhagic transformation after ischemic stroke in animals and humans[J].J Cereb Blood Flow Metab，2014，34（2）：185-199.
[18]	Gasche Y，Copin JC，Sugawara T，et al.Matrix metalloproteinase inhibition prevents ox idative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia[J].JCereb Blood Flow Metab，2001，21（12）：1393-1400.
[19]	Wang X，Lee SR，Arai K，et al.Lipoprotein receptor-mediated induction ofmatrix metalloproteinase by tissue plasminogen activator[J].NatMed，2003，9（10）：1313-1317.
[20]	Del Zoppo GJ，Frankowski H，Gu YH，et al.Microglial cell activation is a source ofmetalloproteinase generation duringhemorrhagic transformation[J].JCereb Blood Flow Metab，2012，32（5）：919-932.
[21]	Kanazawa M，Igarashi H，Kawamura K，et al.Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment[J].JCereb Blood Flow Metab，2011，31（6）：1461-1474.
[22]	Liu DZ，Ander BP，Xu H，et al.Blood-brain barrier breakdown and repair by Src after thrombin-induced injury[J].Ann Neurol，2010，67（4）：526-533.
[23]	Joan M，Molina CA，Jasone M，et al.Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke[J].Circulation，2003，107（4）：598-603.
[24]	Wang L，Wei C，Deng L，et al.The accuracy of serum matrix metalloproteinase-9 for predicting hemorrhagic transformation after acute ischemic stroke：a systematic review and Meta-analysis[J].JStroke Cerebrovasc Dis，2018，27（6）：1653-1665.
[25]	Castellanos M，Leira R，Serena JN，et al.Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke[J].Stroke，2003，34（1）：40-46.
[26]	Castellanos M，Leira R，Serena J，et al.Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke[J].Stroke，2004，35（7）：1671-1676.
[27]	Mendioroz M，Fernandez-Cadenas I，Alvarez-Sabin J，et al.Endogenousactivated protein C predictshemorrhagic transformation and mortality after tissue plasminogen activator treatment in strokepatients[J].Cerebrovasc Dis，2009，28（2）：143-150.
[28]	Choi KH，Park MS，Kim JT，et al.The serum ferritin level is an important predictor of hemorrhagic transformation in acute ischaemic stroke[J].Eur JNeurol，2012，19（4）：570-577.
[29]	Purrucker JC，Wolf M，Haas K，et al.Safety of endovascular thrombectomy in patients receiving non-Vitamin K antagonistoralanticoagulants[J].Stroke，2016，47（4）：1127-1130.
[30]	Kent DM，Hinchey J，Price LL，et al.In acute ischemic stroke，are asymptomatic intracranial hemorrhages clinically innocuous?[J].Stroke，2004，35（5）：1141-1146.
[31]	Cucchiara B，Kasner S，Tanne D，et al.Validation assessment of risk scores to predict postthrombolysis intracerebral haemorrhage[J].Int JStroke，2011，6（2）：109-111.
[32]	Yu Y，Guo D，Lou M，et al.Prediction of hemorrhagic transformation severity in acute stroke from source perfusion MRI[J].IEEE Trans Biomed Eng，2018，65（9）：2058-2065.
[36]	Molina CA，Alvarez-Sabin J，Montaner J，et al.Thrombolysis-related hemorrhagic infarction：amarker of early reperfusion，reduced infarct size，and improved outcome in patients with proximal middle cereb ral artery occlusion[J].Stroke，2002，33（6）：1551-1556.