右美托咪啶对喉罩全麻小儿腹腔镜手术脑电双频谱指数和血流动力学的影响

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Abstract Objective Toexplore theeffect of Dexmedetomidine on electroencephalogram bispectral index(BIS)and hemodynamics in pediatric laparoscopic surgery under general anesthesiawith laryngealmask.Methods A total of 120 children undergoing laparoscopic surgery under general anesthesia with laryngealmask admitted to our hospital from August 2017 to May 2019 were selected as research objects.They were divided into control group(n=60)and experimentalgroup(n=60)according to the random number table method.In thecontrolgroup,normalsalinewas intravenously pumped,and in the experimental group,Dexmedetomidine was intravenously pumped.The BIS value,systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)were observed before medication(T0),3 min after administration(T1),and 6min after administration(T2),9min after administration(T3),12min after administration(T4),15 min after administration(T5),before intubation(T6),1 min after intubation(T7),3 min after intubation(T8)between the two groups.Results There were no significant differences in BIS values between the two groups of children from T0 to T3(P＞0.05).At T4 and T5,the BIS values of children in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in BIS values between the two groups of children from T6 to T8(P＞0.05).The BIS values at T1,T2,T3,T4,T5,T6,T7,and T8 in both groups were lower than those at T0,and the differences were statistically significant(P＜0.05).There were no significant differences in SBP,DBP and MAP between the two groups of children at each time(P＞0.05).The SBP,DBP,and MAP at T1,T2,T3,T4,T5,T6,T7,and T8 of the two groups were lower than those at T0,and the differences were statistically significant(P＜0.05).Conclusion Dexmedetomidine can not only reduce the BIS value of pediatric laparoscopic surgery under general anesthesia with laryngealmask,but also can stabilize hemodynamic indexes in children.

Key words： Dexmedetomidine General anesthesia with laryngealmask Pediatric laparoscopic surgery Electroencephalograph bispectral index Hemodynamics

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	Articles by authors
	YANG Yuan-qi
	XU Shu-qi
	CHEN Jin-yu
	LIU Guang-sheng
	XIAO Jin-ping
	ZHOU Zhi-nuan

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YANG Yuan-qi,XU Shu-qi,CHEN Jin-yu, et al. Effect of Dexmedetom idine on electroencephalogram bispectral index and hemodynam ics in pediatric laparoscopic surgery under general anesthesia with laryngealmask[J]. 中国当代医药, 2020, 27(9): 13-16.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I9/13

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