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2019 Vol. 26, No. 5
Published: 2020-02-18
4
The relationship between folic acid metabolism gene polymorphism,plasma homocysteine level and premature birth and birth weight of newborns
WANG Rui;WU Shu-zhen;CHEN Juan;LI Yi-ying
Objective
To discuss the relationship between folic acid metabolism gene polymorphism,plasma homocysteine (Hcy)level and premature birth and birth weight of newborns.
Methods
A total of 344 pregnant women having prenatal examinations and finally giving birth to their children in our hospital from January 2016 to December 2017 were selected as study objects and their oral mucosa specimens at the early pregnancy stage were collected.According to the results of genetic testing,the genetic risk of folic acid metabolic disorder was graded,and they were divided into the middle/high risk group(182 cases)and non/low risk group(162 cases).Blood samples were taken to detect the level of Hcy.The correlation between Hcy level and neonatal preterm birth and birth weight was analyzed,and the incidence of premature birth was compared between the two groups.
Results
Hcy level was positively correlated with neonatal birth weight(r=0.143,P=0.008);MTRR A66G genotype was positively correlated with neonatal preterm birth(r=0.126,P=0.019);total genotype risk was positively correlated with neonatal preterm birth (r=0.120,P=0.026).The preterm birth rate in the middle/high risk group was higher than that in the non/low risk group (P=0.027).The Hcy level of pregnant women with macrosomia was higher than that of pregnant women with normal birth weight and low birth weight(P＜0.05).There was no significant difference in body redistribution among different risk level of folic acid metabolic disorder(P=0.483).
Conclusion
The utilization of folic acid was correlated with preterm birth.The incidence of preterm birth is significantly increased in the middle/high risk group of folic acid metabolic disorder.Neonatal birth weight is affected by maternal Hcy level,and maternal Hcy level is positively correlated with neonatal birth weight.
2019 Vol. 26 (5): 4-7 [
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129
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8
Determination of related substances in Ketoprofen Gel by high performance liquid chromatography
WANG Xiao-piao;XIAO Xue-cheng▲
Objective
To develop a high performance liquid chromatography (HPLC)method for determining related substances in Ketoprofen Gel.
Methods
Chromatographic colum ZORBAX SB-Phenyl(4.6 mm×250 mm,5 μm)was used,the mobile phase A was 0.15%trifluoroacetic acid acetonitrile solution,and the mobile phase B was 0.15%trifluoroacetic acid solution to conduct the gradient elution.The wavelength of detection was 254 nm,the temperature of column was 30℃,and the flow rate was 1.3 ml/min.
Results
With the established chromatographic conditions,Ketoprofen was well separated from various impurity.The solution of Ketoprofen Gel was stable within 12 hours,and RSD of each impurity and peak was less than 2%.
Conclusion
This method has good specificity and can effectively separate the main components and related substances,and can accurately determine the related substances of Ketoprofen in Ketoprofen Gel.
2019 Vol. 26 (5): 8-11 [
Abstract
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120
)
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12
Influence of MG-132 on TRAIL inducing apoptosis of osteosarcoma cell U-2 OS
FENG Dian-peng;LIU Guang-hui;HAN Qing
Objective
To discusses the influence of MG-132 on TRAIL inducing apoptosis of osteosarcoma cell U-2OS.
Methods
Osteosarcoma cells U-2OS were cultured in 1640 culture medium containing 10%calf serum in a incubator at 37℃and 5%CO
2
saturation humidity.They were divided into single-use TRAIL group,single-use MG-132 group and combined group.After 24 hours of application of the above-mentioned three dosage regimens,and the apoptotic status of MG-132 cells was detected,the cell inhibition rate was calculated,and the cell changes were observed under light microscope.
Results
The effect of apoptosis induction in the single-use TRAIL group was not ideal.With the increase of TRAIL concentration,the apoptosis rate of U-2 OS of bone tumor was continuously increased.The apoptosis rate increased with the increase of drug concentration in single-use MG-132 group,and the difference was statistically significant(P＜0.05).The apoptotic rate of osteosarcoma cells in combined group,single-use TRAIL group and single-use MG-132 group was significantly higher than that in blank control group,and the difference were statistically significant(P＜0.05),and single-use MG-132 group was higher than single-use TRAIL group,and the difference was statistically significant(P＜0.05),and the apoptotic rate of osteosarcoma cells in combined group was significantly higher than that in single-use TRAIL group and single-use MG-132 group,and the difference was statistically significant(P＜0.05).With the passage of time,the cell inhibition rate increased,and the inhibition rate of combined group was significantly higher than that of single-use TRAIL group and single-use MG-132 group,the maximum value reached at 72 hours([82.32±2.54]%),and the difference was statistically significant(P＜0.05).
Conclusion
Single-use TRAIL can induce apoptosis of osteosarcoma cell U-2 OS,but the effect was not ideal and after combining use of MG-132,it can significantly improve the effect of TRAIL induced apoptosis of U-2 OS.
2019 Vol. 26 (5): 12-15-19 [
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106
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16
Research progress of integrated traditional Chinese and western medicine in the treatment of anal edema after hemorrhoid surgery
LIU Guang;ZHANG Meng-ying;ZHANG Lei-chang; LI A-hua
Anal edema is a common complication after anorectal surgery,and it is especially common after hemorrhoid surgery,the incidence rate is as high as 10%to 40%.In clinical practice,this problem is difficult to avoid,so timely and effective treatment of anal edema after hemorrhoid surgery is an urgent problem that clinicians need to think about.This article will explain the causes of anal edema after hemorrhoid surgery from aspects of Chinese and western medicine,and summarize the relevant progress of integrated traditional Chinese and western medicine in the treatment of anal edema after hemorrhoid surgery.
2019 Vol. 26 (5): 16-19 [
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106
)
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20
The treatment progress of portal vein thrombosis of cirrhosis
XU Dan-qing;YANG Jin-hui
Portal venous thrombosis (PVT)is a complication which rare and severe of decompensate cirrhosis.PVT tend to ignore and misdiagnose for it atypical clinical symdrome.The routine treatments for PVT include anticoagulation,thrombolysis,intervention and surgery.Until now,there isn′t a common view about the treatment of PVT.It may be a fatal attack for the patients who can′t receive treatment timely and efficiently.In recent years,with the development of radiological technology,more information of PVT were discovered,it has attracted more attention of clinical workers.This article aims to provide direction and reference for clinical workers by summarizing the treatment progress of PVT patients.
2019 Vol. 26 (5): 20-23 [
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146
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24
Study advances in monitoring methods of renal pelvic pressure in minimally invasive surgery for renal calculi
ZHONG Ling-li;WANG Lue;YANG Jie;LI Wen-ze
Renal calculi are common diseases in department of urology,and their incidence is increasing.With the development of medical equipment,the mainstream of nephrolithotomy has gradually changed from traditional surgery to minimally invasive surgery.Usually,in the minimally invasive surgery of renal calculi,renal pelvis irrigation and perfusion are used to keep the surgical field clear and clear of the gravel.However,the current standard operation may still lead to renal pelvic pressure increasing,resulting in the absorption of perfusion with bacteria and endotoxin through renal regurgitation,causing postoperative fever and sepsis.Therefore,continuous and effective monitoring of intrarenal pressure,and control of the renal pelvis pressure to a certain level can reduce the occurrence of renal regurgitation and improve the safety of minimally invasive surgery of renal calculi.
2019 Vol. 26 (5): 24-27 [
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147
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28
Clinical effect of small needle scalpel combined with ultrasound in the treatment of intractable periarthritis of shoulder
WAN Zhong;DENG Xiao-ling;PENG Tian-zhong
Objective
To study the clinical effect of small needle scalpel combined with ultrasound in the treatment of intractable periarthritis of shoulder.
Methods
A total of 120 patients with intractable periarthritis of shoulder treated in our hospital from July 2017 to August 2018 were selected as the subjects,and divided into the treatment group and the control group according to random number method,with 60 cases in each group.The control group was treated with acupuncture treatment,while the treatment group was treated with acupuncture with ultrasonic wave,autonomic functional exercises were carried out in both groups.After the treatment,the total effective rate,shoulder joint function score before and after treatment and visual analogue scale (VAS)scores before and after treatment between the two groups were compared.
Results
The total effective rate of the treatment group was 96.6%,which was higher than that of the control group(83.3%),and the difference was statistically significant(P＜0.05).After treatment,the shoulder function scores and VAS scores in the treatment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Small needle scalpel combined with ultrasound is effective in the treatment of intractable periarthritis of shoulder,it can effectively improve the pain in lesion of patients and the scope of limited function,which is worthy of promotion and application.
2019 Vol. 26 (5): 28-30 [
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117
)
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31
Study on the clinical effect of Xuebijing Injection combined with Tigefycline in the treatment of pulmonary infection of Acinetobacter Baumannii
HE Wei;MU Xiao-dong;JIA Hui
Objective
To investigate the clinical effect of Xuebijing Injection combined with Tigefycline in the treatment of pulmonary infection of Acinetobacter Baumannii.
Methods
A total of 82 patients with pulmonary infection caused by Acinetobacter Baumannii treated in our hospital from January 2016 to April 2017 were selected as the subjects,and divided into control group and treatment group according to the PC random table method,with 41 cases in each group.The control group received Tegocycline,and the treatment group received Xuebijing Injection combined with Tigecycline.They were treated for 7 to 15 days.Peripheral blood was collected,and the clinical efficacy,C reactive protein (CRP),procalcitonin (PCT),immunoglobulin IgA,IgM and IgG were compared between the two groups.
Results
The total effective rate of the treatment group was lower than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of CRP,PCT,IgA in the treatment group were lower than those in the control group,the differences were statistically significant(P＜0.05).The levels of IgM,IgG in the treatment group were higher than those in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Xuebijing injection combined with tigecycline has a remarkable effect on pulmonary infection caused by Acinetobacter Baumannii,which can reduce levels of CRP and PCT.
2019 Vol. 26 (5): 31-33-37 [
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128
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34
Influence of cognitive intervention in the systemic lupus erythematosus patients with cognitive dysfunction
CHAI Chun-xiang;CHEN Xue-xun; CAO Bo;SU Yu-hua;WANG Xiao-dong;LUAN Qing-xia
Objective
To investigate the influence of cognitive intervention in the systemic lupus erythematosus patients with cognitive dysfunction.
Methods
A total of 46 systemic lupus erythematosus patients with mild or moderate cognitive impairment treated in our hospital from August 2016 to Februry 2018 were selected as the subjects,and randomly divided to intervention group and control group,23 cases in each group.The systemic lupus erythematosus patients in intervention group received 2 hour of cognitive intervention training for 3 times per week.The patients in control group were not intervened.The montreal cognitive assessment(MoCA),basic cognitive ability test and abilities of daily living scale(ADL-BI)afer 3 months were compared.
Results
After cognitive intervention,the scores of MoCA(except language)and abstract and ADL-BI in the experimental group were significantly higher than those of before intervention or those in the control group (P＜0.05).The scores of the basic cognitive ability test were significantly higher than those of before intervention or those in the control group(P＜0.05).
Conclusion
The cognitive intervention may improve cognitive function and abilities of daily living in the systemic lupus erythematosus patients with cognitive impairment.
2019 Vol. 26 (5): 34-37 [
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105
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38
Application effect of cosmetic suturing in emergency skin soft tissue injurie
ZENG Ke;HUANG Jian-qing;WEN Zhi-xiong
Objective
To study the application effect of cosmetic suturing in emergency skin soft tissue injury.
Methods
A total of 40 patients with skin soft tissue injury in emergency treated in our hospital from February to July in 2018 were selected as the subjects,and divided into two groups by random number table method,with 20 cases in each group.The control group was treated with the conventional debridement and suturing methods,and the research group was treated with the cosmetic suturing methods.The suturing effect,wound healing conditions and patients′total satisfaction were compared.
Results
The total effective rate in the study group(95.0%)was significantly higher than control group (80.0%)(P＜0.05).The wound healing time in the research group was (6.42±1.35)d,which was significantly shorter than that in the control group ([7.68±1.84]d)(P＜0.05).The total adverse event rate in the research group(15.0%)was significantly lower than that in the control group (40.0%)(P＜0.05).The patients′total satisfaction in the research group(90.0%)was significantly higher than control group(75.0%)(P＜0.05).
Conclusion
The cosmetic suturing can remarkably increase the suturing effect,shorten the wound healing time,reduce the adverse event rate and meet the patients′aesthetic demands.It is worthy of clinical application and promotion.
2019 Vol. 26 (5): 38-40 [
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108
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41
慢性阻塞性肺疾病；急性发作；呼吸驱动；口腔阻断压
LIU Dong-guo;ZHANG Li-wei;ZHANG Zhen;XIA Kun-gang;TAO Ying-xiu;WEI Jing-liang;LI De-zheng
Objective
To investigate the changes of central respiratory drive during acute exacerbation in patients with chronic obstructive pulmonary disease (COPD)without respiratory failure.
Methods
A total of 88 patients with COPD treated in our hospital from April 2015 to May 2016 were selected as the subjects.None of the patients had respiratory failure.The patients′oral blocking pressure was measured on admission day and after remission,and data analysis was then performed.
Results
Both in awake and asleep states,the oral obstruction pressure (P0.1)of patients with COPD during acute exacerbation was significantly higher than that in remission,and the difference was statistically significant(P＜0.05).The P0.1 in sleep state was lower than that in awake state,and the difference was statistically significant(P＜0.05).
Conclusion
Central respiratory drive of patients with COPD is at a high output in the acute episode,meaning that central respiratory drive is increased in patients with COPD during acute exacerbations,and is weakened in sleep state.
2019 Vol. 26 (5): 41-43 [
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122
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44
Application effect of single operation in painless colonoscopy
CHEN Wei-ping;CHEN Qin-ming
Objective
To analyze the clinical experience of single operation with painless colonoscopy.
Methods
A total of 78 patients with painless colonoscopy admitted to our hospital from February 2017 to February 2018 were selected as the subjects,and randomly divided into control group and observation group by computer,with 39 cases in each group.The control group used painless gastroscopy with double operation,and the observation group used single operation.The clinical indicators and the total incidence of intraoperative adverse reactions were compared between the two groups.
Results
There was no significant difference in systolic blood pressure,diastolic blood pressure and pulse rate of the two groups before and after examination (P＞0.05).After examination,there was no significant difference in systolic blood pressure,diastolic blood pressure and pulse rate between the two groups (P＞0.05).The length of the ileocecal mirror in the observation group was shorter than that in the control group (P＜0.05).The operation time in the observation group was shorter than that in the control group (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05).
Conclusion
Single-person operation is safe and effective in painless colonoscopy,which is worthy of clinical application.
2019 Vol. 26 (5): 44-46 [
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96
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Effect of aerosol inhalation of Salbutamol combined with Suhuang Zhike Capsules in acute exacerbation of chronic obstructive pulmonary disease
YANG Xiao-qing;CHEN Guang;CHEN Xiao-yun;LIU Hou-qiang
Objective
To explore the effect of aerosol inhalation of Salbutamol combined with Suhuang Zhike Capsules in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods
A total of 128 cases with AECOPD treated in our hospital from April 2016 to April 2018 were selected as the subjects,and divided into observation group and control group,with 64 cases in each group.The control group was treated with Salbutamol inhalation,and the observation group was treated with Suhuang Zhike Capsules on the basis of the control group.The curative effect,improvement of pulmonary function and incidence of adverse reactions between the two groups were compared.
Results
The total effective rate of treatment in the observation group was higher than that in the control group (P＜0.05).The values of forced expiratory volume in one second(FEV
1
),FEV
1
/FVC and peak expiratory flowrate(PEF)in the observation group were higher than those in the control group (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).
Conclusion
Salbutamol atomization inhalation combined with Suhuang Zhike Capsules in the treatment of AECOPD can achieve significant effect,improve the pulmonary function.It has good safety and is worthy of clinical application.
2019 Vol. 26 (5): 47-49 [
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151
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Analysis of somatic diseases and clinical medication of chronic schizophrenics patients in long-term hospitalization
YE Fen;GUO Yue-ping;WU Li;XIE Sui-feng;YU Jun;QIN Ping;LIN Li-hua
Objective
To investigate the types of psychiatric drugs,the incidence of somatic diseases and the clinical use of drugs in chronic schizophrenics who have been hospitalized for a long time.
Methods
From January 2014 to July 2018,306 patients were selected by cluster sampling,and their clinical data were retrospectively analyzed,and the patients′combined physical diseases and drug use were statistically analyzed.
Results
A total of 144 cases(47.1%)used single antipsychotic drug,the frequency of the second-generation drug use in the top three were Risperidone(19.6%),Olanzapine(8.5%),Clozapine(6.9%).151 cases(49.3%)used antipsychotic drugs combination.83 cases(27.1%)patients were combined with mood stabilizer,40 cases (13.1%)were combined with antidepressants,and 35 cases(11.4%)were combined with sedative-hypnotic drugs.The frequency of physical diseases were hypertension (20.2%),cases diabetes (15.4%),hyperlipidemia (17.4%),extrapyramidal reaction (17.3%),and sinus tachycardia (15.4%).
Conclusion
Our long-term chronic schizophrenia patients in hospital are mainly treated with second-generation antipsychotics drugs,the combined other psychiatric drugs are reasonable,and the combined physical diseases prevalence rate is low,which have corresponding drug treatment.
2019 Vol. 26 (5): 50-53 [
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115
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54
Comparison of different regimens in the treatment of chronic obstructive pulmonary disease combined with type 2 respiratory failure
XIONG Yan-ping
Objective
To analyze the effect of different regimens in the treatment of chronic obstructive pulmonary disease(COPD)with type 2 respiratory failure.
Methods
Sixty-six patients with COPD and type 2 respiratory failure admitted to our hospital from February 2016 to February 2017 were enrolled in the study.They were divided into control group and observation group according to the order of treatment,with 33 cases in each group.In the control group,routine treatment was used,while in the observation group,conventional treatment combined with non-invasive ventilator treatment was adopted.The clinical treatment effect of the two groups were compared and analyzed.
Results
The heart rate,respiratory rate and arterial blood carbon dioxide partial pressure(PaCO
2
)of the observation group were lower than those of the control group,while the blood oxygen partial pressure(PaO
2
)was higher than that of the control group,with statistical significance(P＜0.05).The clinical treatment effectiveness rate of the observation group was higher than that of the control group,with a significant difference (P＜0.05).The first second forced expiratory volume (FEV
1
)and the ratio of FEV
1
to the forced vital capacity ratio (FEV
1
/FVC)were lower than those of the control group,with statistical differences(P＜0.05).The quality of life score of the observation group was higher than that of the control group,with statistical significance (P＜0.05).
Conclusion
For patients with COPD and type 2 respiratory failure,on the basis of the conventional treatment,the combination of non-invasive ventilator can improve the lung function and lung ventilation,patients′breathing and heart rate,as well as patients′quality of life with a high clinical therapeutic effect.
2019 Vol. 26 (5): 54-56 [
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121
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Influence of Acetylcysteine Effervescent Tablets on cardiopulmonary function and airway remodeling in patients with stable chronic obstructive pulmonary disease
LI Na
Objective
To analyze the changes of cardiopulmonary function and airway remodeling level in patients with stable chronic obstructive pulmonary disease after adjuvant therapy of Acetylcysteine (NAC)Effervescent Tablets.
Methods
Ninety patients with stable chronic obstructive pulmonary diseases (COPD)admitted to our hospital from August 2016 to August 2017 were selected as the subjects,and divided into two groups by random number table methods,with 45 patients each group.The control group were treated with conventional methods,and the observation group were treated with Acetylcysteine Effervescent Tablets as adjuvant therapy.The oxidative stress-related products in the serum,the levels of inflammation in peripheral blood and airway remodeling,and the level of lung function were compared.
Results
There was no significant difference in the indicators between the two groups before treatment(P＞0.05).After treatment,the levels of MDA,protein C (PC)and 8-hydroxydeoxyguanosine(8-OHdG)in the observation group were significantly lower than those in the control group,and the total antioxidant capacity of TAC was higher than that of the control group,the differences were statistically significant(P＜0.05).After treatment,the levels of oligomeric domain-like receptor protein 3 (NLRP3),spot-like protein ASC,p38 protein kinase (p38MAPK),and myeloid cell-evoked receptor 1(TREM-1)in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of matrix metalloproteinase 2 (MMP-2),matrix metalloproteinase 3(MMP-3)and matrix metalloproteinase 9(MMP-9)in the observation group were lower than those in the control group,and the levels of matrix metalloproteinase inhibitor TIMP-1 and matrix metalloproteinase inhibitor TIMP-2 were higher than those in the control group,and the differences were statistically significant(P＜0.05).The first-second forced expiratory volume(FEV
1
),the ratio of first-second forced expiratory volume to the forced vital capacity(FEV
1
/FVC),and the percentage of predicted FEV
1
(FEV
1
%)in the observation group were lower than those in the control group,the differences were statistically significantt(P＜0.05).
Conclusion
NAC Effervescent Tablets as an adjuvant therapy for stable COPD can effectively improve the cardiopulmonary function and airway remodeling of patients,and can significantly improve the quality of life of patients.
2019 Vol. 26 (5): 57-60-73 [
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92
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Comparison effect of Alogliptin and Acarbose in the treatment of newly diagnosed type 2 diabetes mellitus and their effects on gastrointestinal related hormones
XU Rong;XIA Wen-yan;GUO Li;ZENG Shu-qin;LYU Wei-ming▲
Objective
To investigate the clinical effects of Alogliptin and Acarbose on newly diagnosed type 2 diabetes mellitus(7%＜HbA1c＜8.5%)and their effects on gastrointestinal hormones.
Methods
Sixty newly diagnosed type 2 diabetes mellitus patients in the Department of endocrinology of our hospital from January 2017 to January 2018 were selected,they were divided into treatment group and control group according to random number table method,with 30 cases in each group.The patients in the treatment group were treated with Alogliptin and the patients in the control group were treated with Acarbose for 24 weeks.Blood sugar,HbA1c and body mass index(BMI)were compared between the two groups before and after treatment,changes of gastrointestinal hormones and occurrence of adverse reactions.
Results
The levels of fasting blood glucose(FPG),postprandial 2-hour blood glucose(2-hour PG)and HbA1c in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).BMI level of the two groups after treatment was lower than that before treatment,but there was no significant difference(P＞0.05).There was no significant difference in FPG,2 h PG and HbA1c between the two groups(P＞0.05).Gastrin and gastrin levels in the treatment group after treatment were lower than those before treatment on fasting and 2 hours after meal(P＜0.05).In the control group after treatment,the level of ghrelin in fasting and 2 hours after meal was lower than that before treatment,and the level of ghrelin in fasting and 2 hours after meal was higher than that before treatment,but there was no significant difference(P＞0.05).The levels of ghrelin and gastrin in the treat-ment group after treatment were lower than those in the control group on fasting and 2 hours after meal(P＜0.05).There were no severe gastrointestinal adverse reactions and severe hypoglycemia in both groups.
Conclusion
Both Alogliptin and Acarbose significantly improved blood sugar in newly diagnosed type 2 diabetes mellitus(7%＜HbA1c＜8.5%),however,the effect of agritin on reducing fasting and postprandial gastrin is more significant,and it can be used as an effective clinical treatment for type 2 diabetes mellitus.
2019 Vol. 26 (5): 61-63 [
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125
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Analysis of clinical characteristics of newly diagnosed type 2 diabetes mellitus with acute pancreatitis
SONG Jin-zhan;XU Guang-yao▲
Objective
To explore the clinical characteristics of type 2 diabetes mellitus(T2DM)first diagnosed with acute pancreatitis(AP),and to improve the diagnosis and treatment of such patients.
Methods
A retrospective analysis was made of 14 patients with initial T2DM who were first diagnosed with AP in Yanqing District Hospital of Beijing from October 2012 to October 2018.20 patients with AP who were not combined with DM in the same period were selected as control group.The clinical characteristics of initial T2DM who were first diagnosed with AP were summarized.
Results
The body mass index(BMI)of the observation group was significantly higher than that of the control group,the difference was significant(P＜0.05).The incidence of non-induced pancreatitis in the observation group was 0.00%,which was lower than 25.00%in the control group (P＜0.05).There was no significant difference in the incidence of severe pancreatitis,cholelithiasis,severe hypertriglyceridemia(HTG),alcoholism and overeating between the two groups(P＞0.05).The levels of triglyceride(TG),fasting blood glucose(FBG)and glycosylated hemoglobin(HbA1c)in the observation group were significantly higher than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in total cholesterol(TC),serum amylase(AMY)and lipase(LIPA)levels between the two groups(P＞0.05).In the observation group,6 patients(42.86%)had diabetic ketosis or diabetic ketoacidosis(DKA),6 patients were overweight(42.86%)and 5 patients were obese(35.71%).
Conclusion
Type 2 diabetes mellitus patients with AP are more likely to be overweight,complicated with HTG and cholelithiasis,complicated with acute metabolic disorders of diabetes mellitus,which can aggravate organ damage,and have a high probability of severe pancreatitis,which increases the difficulty of diagnosis and treatment.It should be paid attention to in clinical work.
2019 Vol. 26 (5): 64-66 [
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100
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Expression of inflammatory factors in patients with diabetic nephropathy and their correlation with renal function
ZHANG Gui;YANG Yi;LU Xiu-hong
Objective
To investigate the expression of inflammatory factors in patients with diabetic nephropathy and its correlation with renal function.
Methods
Ninety patients with diabetes mellitus admitted to our hospital from February 2016 to August 2018 were selected as the research objects,according to the 24-hour urinary microalbuminuria excretion rate,they were divided into three groups,observation group 1 (normal albuminuria),observation group 2(microalbuminuria)and observation group 3 (clinical albuminuria),thirty patients in each group were selected as the control group.The levels of serum inflammatory factors(C-reactive protein,interleukin-6,tumor necrosis factor-α)and renal function indexes(serum creatinine,cystatin C,urinary albumin excretion rate (UAER)were compared among the four groups.Pearson correlation analysis was used to determine the relationship between inflammatory factors and renal function.
Results
The levels of C-reactive protein,interleukin-6,tumor necrosis factor-α,serum creatinine,cystatin C and UAER in the observation group were significantly higher than those in the control group,the differences were significant(P＜0.05).The levels of inflammatory factors in serum of the observation groups 3 were higher than those of the observation groups 1 and 2,the differences were significant(P＜0.05).C-reactive protein,interleukin-6 and tumor necrosis factor-α were positively correlated with serum creatinine,cystatin C and UAER(P＜0.05).
Conclusion
There is a correlation between the levels of inflammatory factors and renal lesions in patients with diabetes mellitus.
2019 Vol. 26 (5): 67-69 [
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91
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Effect of Shenqi Fuzheng Injection in the adjuvant treatment of breast cancer and its influence on hematopoietic function and immune function
WANG Zhen-bin
Objective
To study and analyze the effect of Shenqi Fuzheng Injection in the adjuvant treatment of breast cancer and its influence on hematopoietic function and immune function.
Methods
From January 2015 to January 2018,100 patients with breast cancer who were confirmed by breast surgery in our hospital were selected as the research object.All patients were divided into the experimental group and the control group according to the random number table method,50 patients in each group.The control group was given routine CAF chemotherapy.The experimental group was given Shenqi Fuzheng Injection on the basis of the control group,and treated with chemotherapy for 28 days.The hematopoietic indexes(such as WBC,Hb,PLT)and immune indexes(such as IL-2,IL-4,IL-10,and IFN-γ)were compared before and after treatment between the two groups.
Results
There was no significant difference in WBC,Hb,PLT and other hematopoietic indexes between the two groups before treatment(P＞0.05).After different treatments,the levels of WBC,Hb and PLT in the experimental group were not significantly different from those before treatment(P＞0.05).After treatment,the level of WBC,Hb,PLT and other hematopoietic indexes in the control group were significantly lower than those before treatment,with significant difference (P＜0.05).The levels of WBC,Hb and PLT in the experimental group after treatment were lower than those in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the immune indexes of IL-2,IL-4,IL-10 and IFN-γ between the two groups before treatment(P＞0.05).After different treatments,the levels of IL-2 and IFN-γ in the experimental group were significantly higher than those before treatment,and the levels of IL-4 and IL-10 in the experimental group were significantly lower than those before treatment,the difference was statistically significant(P＜0.05).The levels of IL-2 and IFN-γ in the control group after treatment were significantly higher than those before treatment,and the difference was statistically significant(P＜0.05).There was no significant difference in the levels of IL-4 and IL-10 between after and before treatment in the control group(P＞0.05).After treatment,the levels of IL-2 and IFN-γ in the experimental group were significantly higher than those in the control group,and the levels of IL-4 and IL-10 in the experimental group after treatment were significantly lower than those in the control group,the difference was statistically significant(P＜0.05).The total effective rate of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Shenqi Fuzheng Injection can significantly improve the hematopoietic function and immunity of patients with breast cancer,and improve the treatment effect.It is superior to chemotherapy alone.It is worthy of clinical promotion and application.
2019 Vol. 26 (5): 70-73 [
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99
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74
Effect of Gemcitabine combined with Cisplatin transarterial chemoembolization in the treatment of patients with hepatocellular carcinoma
ZHAO Qiang-de;WANG Jiao-long;LI Chun-yan
Objective
To discuss the effect of transarterial chemoembolization(TACE)in the treatment of patients with hepatocellular carcinoma.
Methods
A total of 60 patients with hepatocellular carcinoma admitted to our hospital from April 2014 to October 2016 were selected as the research objects.They were divided into the control group and the observation group according to the different treatment methods,30 cases in each group.The control group was treated with Fluorouracil and TACE,while the observation group was treated with Gemcitabine plus Cisplatin and TACE,and the index changes of the two groups were compared.
Results
The total effective rate of the observation group in one year after treatment was 93.33%,which was higher than that of the control group (73.33%),and the difference was statistically significant(P＜0.05).There were no significant differences in levels of serum vascular endothelial growth factor(VEGF),tissue growth factor(CTGF),soluble interleukin-2R(sIL-2R),hypoxia inducible factor-2α (HIF-2α)between the observation group and the control group before treatment(P＞0.05).The levels of serum VEGF,CTGF,sIL-2R and HIF-2α in the two groups after treatment were significantly different from those before treatment(P＜0.05).The levels of serum VEGF,CTGF,sIL-2R and HIF-2α in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The 2-year survival rate in the observation group was 63.33%,which was higher than 36.67%in the control group,and the difference was statistically significant(P＜0.05).The incidence rate of adverse reactions was 13.33%in the observation group and 16.67%in the control group,there was no significant difference between the two groups(P＞0.05).
Conclusion
Gemcitabine combined with Cisplatin via TACE has obvious curative effect on patients with hepatocellular carcinoma,without increasing toxicity and side effects.It has important promotion and application value.
2019 Vol. 26 (5): 74-76 [
Abstract
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118
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77
Effect of high dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain
ZHOU Yu;LI Ling;LI Jie
Objective
To explore the efficacy of high-dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain.
Methods
A total of 48 patients with advanced cancer pain admitted to our hospital from April 2017 to April 2018 were selected as the study subjects.They were divided into the control group(n=24)and the observation group(n=24)according to different treatment methods.The control group was treated with Morphine Sulfate Sustained-Release Tablets,while the observation group was treated with high-dose(120-280 mg)Oxycodone Hydrochloride Sustained-Release Tablets.The pain digital scoring method (NRS)scores,analgesic effects and adverse reactions were compared between the two groups before treatment and 15 days after treatment.
Results
There was no statistically significant difference in the NRS score between the two groups before treatment(P＞0.05).The NRS scores of the two groups after 15 d treatment were significantly lower than those before treatment(P＜0.05).Compared with the control group,the NRS score of the observation group decreased more significantly after treatment(P＜0.05).The total effective rate of analgesia in the observation group was significantly higher than that in the control group after 15 days of treatment,with significant difference (P＜0.05).The total incidence of adverse drug reactions in the observation group was significantly lower than that in the control group,with significant difference (P＜0.05).
Conclusion
High-dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain patients have reliable efficacy,with obvious analgesic effect,less adverse reactions,good safety,it is worthy of clinical reference and application.
2019 Vol. 26 (5): 77-79 [
Abstract
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105
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80
Survival situation and prognostic factors analysis of 53 glioma patients treated with radiotherapy after surgery
WANG Hai-jing;ZHAO Wei-yong;BI Liang-wen;ZHANG Li-zhen;TIAN Ji-hong
Objective
To investigate the survival situation and prognostic factors of the glioma patients treated with radiotherapy after surgery.
Methods
The clinical data of 53 patients with glioma treated in our hospital from November 2004 to February 2017 were analyzed retrospectively.Kaplan Meier method was used for survival analysis,and Cox model was used for univariate and multivariate analysis.
Results
The survival rates at 1,2,5 years were 66.0%,45.3%and 24.5%,respectively.The median survival was 20 months.Univariate analysis showed that age,KPS score and WHO grade were associated with overall survival(P＜0.05).Multivariate analysis indicated that KPS score and WHO grade were independent prognostic factors(P＜0.05).
Conclusion
KPS＞70 points and low WHO grade are independent prognostic factors for glioma patients.
2019 Vol. 26 (5): 80-82 [
Abstract
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133
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83
Effect comparison of ultrasound-guided Mamotong breast minimally invasive surgery and conventional surgery in the treatment of benign breast tumors
YAN Li
Objective
To compare the effect of ultrasound-guided Mamotong breast minimally invasive surgery and conventional surgery in the treatment of benign breast tumors.
Methods
A total of 60 patients with benign breast tumors admitted to our hospital from March 2015 to February 2017 were enrolled.According to the treatment method,they were divided into the study group (30 cases)and the control group (30 cases).The control group used traditional surgery,the study group underwent ultrasound-guided Mamotong breast minimally invasive surgery.The operation time,hospital stay,intraoperative blood loss,the incidence rate of complication and treatment satisfaction between the two groups were compared.
Results
The operation time,hospitalization time,healing time,scar length of the study group were shorter than those of the control group,intraoperative blood loss of the study group was less than that of the control group,the incidence rate of postoperative complication rate,VAS score of the study group were lower than those of the control group,and the treatment total satisfaction of the study group was higher than that of the control group,with significant difference (P＜0.05).
Conclusion
Ultrasound-guided Mamotong breast minimally invasive surgery has a significant effect on patients with benign breast tumors.The operation time is shorter,the intraoperative blood loss is less,the hospital stay is shorter,and the postoperative complications are less,postoperative recovery is rapid,it is worth promoting in the clinic.
2019 Vol. 26 (5): 83-85 [
Abstract
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119
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18
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86
Application value of PGⅠ,PGⅡand G-17 in the diagnosis of gastric cancer and atrophic gastritis
WU Feng;ZHOU Zheng-qian;LIU Zeng-yong;SHUAI Shu-hao
Objective
To investigate the application value of PGⅠ,PGⅡand G-17 in the diagnosis of gastric cancer and atrophic gastritis.
Methods
A total of 120 patients with gastritis and gastric cancer admitted to our hospital from August 2016 to January 2018 were selected and divided into group A (40 patients with atrophic gastritis),group B(40 patients with superficial gastritis)and group C (40 patients with gastric cancer)according to the patient′s disease condition.The serum levels of PGⅠ,PGⅡand G-17 were analyzed.
Results
The levels of PGⅠ and PGⅡin group B were significantly higher than those in other two groups,and the levels of PGⅠ and PGⅡ in group A were significantly higher than those in group C,with significant difference(P＜0.05).The levels of G-17 in group C were significantly higher than those in other two groups,but the levels of PGR in group C were significantly lower than those in other two groups(P＜0.05).At the same time,the levels of PGⅠ and PGⅡ in Hp-positive patients were significantly higher than those in Hp-negative patients (P＜0.05).
Conclusion
PGⅠ,PGⅡ combined with G-17 can effectively reflect the pathological changes of gastric mucosa in patients with atrophic gastritis,and provide accurate data for the diagnosis of early gastric cancer,and provide a guarantee for clinical treatment.
2019 Vol. 26 (5): 86-88 [
Abstract
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81
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89
Clinical effect of addition and subtraction of Dachaihu Decoction and Liujunzi Decoction in the treatment of post-embolization syndrome of liver cancer
ZHANG Xin-ting
Objective
To investigate the clinical effect of addition and subtraction of Dachaihu Decoction and Liujunzi Decoction in preventing and treating post-embolization syndrome of liver cancer.
Methods
A total of 240 patients with post-hepatic embolism syndrome admitted to our hospital from December 2016 to October 2018 were enrolled in the study.According to the computer random method,the patients were divided into the observation group (120 cases)and the control group(120 cases).The observation group was treated with conventional western medicine combined with addition and subtraction of Dachaihu Decoction and Liujunzi Decoction,and the control group was treated with conventional western medicine.The quality of life score,duration of symptoms and liver function were compared between the two groups of patients with post-embolic embolization syndrome.
Results
After treatment,the quality of life score in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).The duration of abdominal pain,nausea and fever in the observation group was shorter than that in the control group,the difference was statistically significant(P＜0.05).The levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in the observation group were lower than those in the control group at 2,7 days after operation,the difference was statistically significant(P＜0.05).There was no significant difference in the level of total bilirubin (TBil)between the two groups at 2 and 7 days after operation (P＞0.05).
Conclusion
Addition and subtraction of Dachaihu Decoction and Liujunzi Decoction in the treatment of patients with post-embolization syndrome can effectively improve the prognosis,shorten the duration of adverse symptoms,and have higher clinical value.
2019 Vol. 26 (5): 89-91 [
Abstract
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86
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92
Clinical effect of trans-catheter arterial chemoembolization combined with ultrasound-guided radiofrequency ablation in the treatment of large hepatocellular carcinoma with lack of blood supply
YU Hai-bin
Objective
To investigate the clinical effect of trans-catheter arterial chemoembolization (TACE)combined with ultrasound-guided radiofrequency ablation (RFA)in the treatment of large hepatocellular carcinoma with lack of blood supply.
Methods
Altogether 68 patients with large hepatocellular carcinoma with lack of blood supply who were treated in our hospital from May 2013 to May 2016 were selected and divided into the experiment group and the control group by random number table method,with 34 patients in each group.The control group was treated with simple trans-catheter arterial chemoembolization,while the experiment group was treated with ultrasound-guided radiofrequency ablation after TACE.The clinical effects and complications of the two groups were observed,and the survival rates of the two groups within one and two years after operation were followed up and compared.
Results
The total effective rate of the experiment group was 85.29%,which was higher than that of the control group(73.53%),with statistically significant difference(P＜0.05).There was no statistically significant difference in the incidence rate of complications between the two groups(P＞0.05).The post-operative 1-year and 2-year survival rates of the experiment group were 76.47%and 47.06%respectively,which were higher than those of the control group (52.94%and 26.47%),with statistically significant difference(P＜0.05).
Conclusion
TACE combined with ultrasound-guided RFA has a significant clinical effect in the treatment of large hepatocellular carcinoma with lack of blood supply,which can effectively prolong the survival time of patients with good safety,and it is worthy of clinical promotion and application.
2019 Vol. 26 (5): 92-94 [
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84
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95
Influential factors and prognosis of pathological complete remission of neoadjuvant therapy for breast cancer
LI Shuai;MA Wen-jing;MA Jing;TANG Hui
Objective
To explore the influencing factors and prognosis of pathological complete remission of neoadjuvant therapy for breast cancer.
Methods
The clinical data of 150 patients with breast cancer admitted to People′s Hospital of Xinjiang Uygur Autonomous Region from June 12,2010 to June 12,2015 were retrospectively analyzed.All of them were women who received neoadjuvant chemotherapy.The clinical data,pathological data and follow-up data were collected and analyzed to explore the influencing factors and prognosis of pathological complete remission.
Results
Body mass,lactation time,chemotherapy cycle,tumor size,ER,PR,ER/PR and molecular typing were all single factors affecting the complete remission of neoadjuvant therapy.Complete remission has no significant effect on survival of breast cancer patients.
Conclusion
For breast cancer patients,body mass and ER are independent predictors of pathological complete remission of neoadjuvant therapy,and the pathological complete remission of neoadjuvant therapy has no significant impact on prognosis and survival of breast cancer patients.
2019 Vol. 26 (5): 95-97 [
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96
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98
Changes and clinical significance of serum 25-hydroxyvitamin D levels in children with Kawasaki disease
ZHANG Xiao-ying;LI Chao-xiong;OU Zhong-ai;LIN Na-na;ZHENG Xiao-yan
Objective
To investigate the changes and clinical significance of serum 25-hydroxyvitamin D (25-[OH]D)levels in children with Kawasaki disease(KD).
Methods
The clinical data of 147 children aged 1-3 years old with KD hospitalized in our hospital from September 2009 to September 2017 were retrospectively analyzed.According to whether coronary artery lesion(CAL)occured,they were divided into the CAL group(76 cases)and the non-CAL group(NCAL,71 cases).According to the efficacy of intravenous immunglobulin (IVIG),they were divided into the immunglobulin sensitive KD group(117 cases)and the immunglobulin unresponsive KD group(30 cases).Another 58 healthy children of this age during the same period were selected as the control group.Serum 25-(OH)D levels were measured by enzyme-linked immunosorbent assay among the groups.
Results
The level of serum 25-(OH)D in the CAL group was(33.24±7.74)nmol/L,which was lower than that in the NCAL group accounting for(38.72±10.82)nmol/L and the control group accounting for(43.00±13.10)nmol/L,and the differences were statistically significant(P＜0.05).The level of serum 25-(OH)D in the NCAL group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The level of serum 25-(OH)D in the immunglobulin unresponsive KD group was(32.60±6.41)nmol/L,which was lower than that in the immunglobulin sensitive KD group accounting for(36.79±10.31)nmol/L and the control group accounting for(43.00±13.10)nmol/L,and the differences were statistically significant(P＜0.05).The level of serum 25-(OH)D in the immunglobulin sensitive KD group was lower than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusions
The level of serum 25-(OH)D is low in children with KD,and it is much lower especially in the incidence of CAL and under the immunglobulin unresponsive condition.
2019 Vol. 26 (5): 98-100-104 [
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103
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101
Effect of early micro-feeding on the number of Intestinal Lactobacilli and Bifidobacteria and the incidence of feeding intolerance in premature infants
JIANG Tao;LI Yu-qin;HUANG Wen-wu;LI Hai-yan
Objective
To investigate the effect of early micro-feeding on the number of Intestinal Lactobacilli and Bifidobacteria and the incidence of feeding intolerance in premature infants.
Methods
A total of 410 premature infants admitted to our hospital from August 1,2016 to February 1,2018 were selected as the study subjects.According to the random envelope method,they were divided into the observation group(205 cases)and the control group(205 cases).In the control group,routine protocols as the intervention were used,while in the observation group,early micro-feeding protocols as the intervention were adopted.The time to recover birth weight,time of gastric tube removal,time of total enteral nutrition,hospitalization time,the levels of Intestinal Lactobacilli and Bifidobacteria,and incidence of feeding intolerance were compared between the two groups.
Results
The time to recover birth weight,time of gastric tube removal,time of total enteral nutrition,and hospitalization time of the premature infants in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in the levels of Intestinal Lactobacilli and Bifidobacteria between the two groups 3 days after treatment(P＞0.05).The levels of Intestinal Lactobacilli and Bifidobacteria at 7 and 14 days after treatment in the two groups were significantly higher than those at 3 days after treatment,and the differences were statistically significant(P＜0.05).The levels of Intestinal Lactobacilli and Bifidobacteria at 7 and 14 days after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence rate of feeding in-tolerance in the observation group was 19.02%,which was significantly lower than that in the control group (66.34%),and the difference was statistically significant(P＜0.05).
Conclusion
Early micro-feeding can effectively improve the number of Intestinal Lactobacilli and Bifidobacteria and reduce the incidence rate of feeding intolerance after intervention in premature infants.
2019 Vol. 26 (5): 101-104 [
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85
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105
Application study of high quality PU leather sponge circle nest in neonatology
SHEN Jin-di;LIU Jian-ying;LIU Yu-ping;WANG Xiao-xia
Objective
To investigate the application study of high quality PU leather sponge circle nest in neonatology.
Methods
A total of 94 newborns treated in the neonatology department of Ruijin Maternal and Child Health Care Hospital from August to December 2016 were enrolled in the study.They were divided into the control group (n=47)and the study group (n=47)according to the different bird nest methods.Newborns in the control group were placed in the nest using an autoclave bath towel,and newborns in the study group were given the high quality PU leather sponge circle nest.The nest applicability rate,reset rate and replacement rate during neonatal care,skin abrasions,skin indentation and economic cost due to the nest were compared between the two groups.
Results
The nest applicability rate during neonatal care was 100.00%in the study group,which was significantly higher than that in the control group accounting for 44.68%,reset rate and replacement rate were both 0.00%,which were lower than those in the control group accounting for 34.04%and 21.28%respectively,and the differences were statistically significant(P＜0.05).The incidence rate of skin abrasion in the study group was 2.13%,the incidence rate of skin indentation was 6.38%,which were significantly lower than those in the control group accounting for 21.28%and 29.79%respectively,and the differences were statistically significant(P＜0.05).The economic cost of the nest in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
The application effect of high quality PU leather sponge circle nest in the neonatology is certain,safe and comfortable,and the cost is not high,which can be referred.
2019 Vol. 26 (5): 105-107 [
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80
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108
Clinical effect of Immunoglobulin in the treatment of inflammatory reaction in children with rotavirus enteritis
HUANG Lie-peng
Objective
To explore the effect of Immunoglobulin in the treatment of inflammatory reaction in children with rotavirus enteritis.
Methods
Sixty four children with rotavirus enteritis admitted to our hospital from October 1,2016 to February 1,2018 were selected as research subjects.They were divided into control group (32 cases)and observation group (32 cases)according to the random sampling method.The control group received conventional symptomatic treatment and placebo,and the observation group received intravenous Immunoglobulin on the basis of the conventional symptomatic treatment.The fresh feces of the two groups were collected as specimens.The total effective rate of treatment,the levels of tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6)and secretory immunoglobulin A(SIgA)before and after treatment were compared between the two groups.
Results
The total effective rate of treatment in the observation group was 93.75%,which was higher than that in the control group(75.00%),and the difference was statistically significant(P＜0.05).There were no significant differences in the levels of TNF-α and IL-6 between the two groups before treatment(P＞0.05).The levels of TNF-α and IL-6 after treatment in the two groups were significantly lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of TNF-α and IL-6 after treatment in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the level of SIgA between the two groups before treatment(P＞0.05).The levels of SIgA on the 1
st
,2
nd
,3
rd
,4
th
,and 5
th
days after treatment in the two groups were higher than those before treatment,and the differences were statistically significant(P＜0.05).The levels of SIgA on the 1
st
,2
nd
,3
rd
,4
th
,and 5
th
days after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
The effect of Immunoglobulin is significant in the treatment of the inflammatory reaction in children with rotavirus enteritis.
2019 Vol. 26 (5): 108-110 [
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85
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111
Clinical effect and safety of the laparoscopic surgery in the treatment of ectopic pregnancy
ZHANG Xiao-xiang
Objective
To investigate the clinical effect and safety of laparoscopic surgery in the treatment of ectopic pregnancy.
Methods
A total of 60 patients with ectopic pregnancy treated in our hospital from February 2012 to February 2018 were selected as research objects.They were divided into the treatment group 1 (30 cases)and the treatment group 2(30 cases)according to the random number table method.Patients in the treatment group 1 underwent laparoscopic surgery,and patients in the treatment group 2 underwent conventional laparotomy.The recovery conditions(hospitalization time,recovery time of blood human chorionic gonadotropin[β-HCG],recovery time of menstruation),tubal patency rate,cure rate,complication rate and perioperative efficacy(operative time,intraoperative blood loss,postoperative anal exhaust time)were compared between the two groups.
Results
The hospitalization time,recovery time of blood β-HCG and recovery time of menstruation in the treatment group 1 were significantly shorter than those in the treatment group 2,and the differences were statistically significant(P＜0.05).The tubal patency rate and cure rate of the patients in the treatment group 1 were higher than those in the treatment group 2,the complication rate was lower than that in the treatment group 2,and the differences were statistically significant(P＜0.05).The operation time and postoperative anal exhaust time in the treatment group 1 were shorter than those in the treatment group 2,the intraoperative blood loss was less than that in the treatment group 2,and the differences were statistically significant(P＜0.05).
Conclusion
Laparoscopic surgery applied to ectopic pregnancy can improve the patients′tubal patency rate,cure rate,shorten hospitalization time,blood β-HCG recovery time and menstrual recovery time,safe and reliable,with fewer complications,which is worthy of application and promotion.
2019 Vol. 26 (5): 111-113 [
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83
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Effect comparison of different doses of glucocorticoid in the adjuvant treatment of pediatric refractory Mycoplasma pneumonia complicated with extrapulmonary complications
TANG Lu-xiao
Objective
To compare the effect of different doses of glucocorticoid in the adjuvant treatment of pediatric refractory Mycoplasma pneumonia complicated with extrapulmonary complications.
Methods
One hundred children with refractory Mycoplasma pneumonia complicated with extrapulmonary complications admitted to our hospital from January to December 2016 were selected as research objects.They were divided into the control group and the observation group according to the computer randomization grouping method,with 50 cases in each group.In the control group,a small dose of glucocorticoid as an adjuvant therapy was used,and in the observation group,a conventional dose of glucocorticoid as an adjuvant therapy was adopted.The clinical treatment effect,clinical symptom improvement time(cough disappearance time,wheezing disappearance time,body temperature recovery normal time,lung voice disappearance time,X-ray shadow disappearance time),hospitalization time and related laboratory indicators(C-reactive protein[CRP],D-dimer,lactate dehydrogenase [LDH],erythrocyte sedimentation rate [ESR])were compared between the two groups.
Results
The total effective rate of treatment in the observation group was 98.00%,which was significantly higher than that in the control group (74.00%),and the difference was statistically significant(P＜0.05).The cough disappearance time,wheezing disappearance time,body temperature recovery normal time,lung voice disappearance time,X-ray shadow disappearance time,and hospitalization time in the observation group were shorter those in the control group,and the differences were statistically significant(P＜0.05).The levels of CRP,D-dimer,LDH and ESR in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Conventional doses of glucocorticoid in the treatment of refractory Mycoplasma pneumonia complicated with extrapulmonary complications has a remarkable clinical effect,which not only can shorten the hospital stay,but also improve the clinical symptoms and laboratory indicators,and is worthy of study.
2019 Vol. 26 (5): 114-116 [
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87
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117
Feasibility of super early comprehensive rehabilitation in the treatment of brain injury in premature infants
WU Wen-hua;ZHANG Hui-qin
Objective
To explore the feasibility of super early comprehensive rehabilitation in the treatment of brain injury in premature infants.
Methods
A total of 80 cases of premature infants with brain injury treated in our hospital from May 2014 to April 2015 were selected as research objects and divided into routine intervention group(27 cases),early intervention group(27 cases)and super early intervention group(26 cases).The routine intervention group,the early intervention group and the super early intervention group were given the comprehensive rehabilitation treatment at the neonatal period to 3 month old,2 months of age correction and 40 weeks of fetal age respectively.Gesell scale was used the measure the developmental quotient(DQ)at 6,9,12,18,and 24 months of the three groups.The incidence rates of cerebral palsy,general developmental delay and language development retardation were compared among the three groups.
Results
The DQ scores of large operation,fine operation,cognitive ability,language and social behavior at 6,9,12,18,and 24 months in the super early intervention group were significantly higher than those in the routine intervention group and the early intervention group,and the differences were statistically significant(P＜0.05).The incidence rate of cerebral palsy in the super early intervention group was significantly lower than that in the routine intervention group and the early intervention group,and the differences were statistically significant(P＜0.05).The incidence rate of general developmental delay in the super early intervention group was significantly lower than that in the routine intervention group and the early intervention group,and the differences were statistically significant(P＜0.05).The incidence rate of language development retardation in the super early intervention group was significantly lower than that in the routine intervention group and the early intervention group,and the differences were statistically significant(P＜0.05).
Conclusion
The effect of super early comprehensive rehabilitation in the treatment of premature infants with brain injury is significant.It can effectively promote the development of athletic ability,intelligence and language,reduce the incidence rates of cerebral palsy,general developmental delay and language development retardation,which is worthy of clinical promotion.
2019 Vol. 26 (5): 117-119-122 [
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92
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Clinical effect of Amoxicillin and Clavulanate Potassium in the treatment of urinary tract infection in children
ZHAO Qiu-hua;LIU Xiu-shu;LIN Le-xin
Objective
To explore the clinical effect of Amoxicillin and Clavulanate Potassium in the treatment of urinary tract infection in children.
Methods
The clinical data of 118 children with urinary tract infection admitted to our hospital from September 2015 to September 2017 were retrospectively analyzed.According to the different treatment methods,they were divided into the control group and the observation group,with 59 cases in each group.Children treated with Ceftriaxone Sodium were selected as the control group,and children treated with Amoxicillin Clavulanate Potassium were selected as the observation group.The clinical treatment effect,antipyretic time,urinary bacteria turning into negative time,bacterial clearance rate and adverse reactions were compared between the two groups.
Results
The total effective rate of treatment in the observation group was 96.61%,which was higher than that in the control group(84.44%),and the difference was statistically significant(P＜0.05).The antipyretic time and urinary bacteria turning into negative time in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).The bacterial clearance rate of the observation group was 95.59%,which was higher than that of the control group (81.54%),and the difference was statistically significant(P＜0.05).The total incidence rate of adverse reactions in the observation group was 5.08%,compared with 8.47%in the control group,and the difference was not statistically significant(P＞0.05).
Conclusion
Amoxicillin and Clavulanate Potassium has a good effect in the treatment of urinary tract infection,and it can significantly shorten the healing time of children,has higher bacterial clearance rate and fewer adverse reactions,which is worthy of clinical application and promotion.
2019 Vol. 26 (5): 120-122 [
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111
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123
Effect of Fuke Zaizao Capsules in the treatment of decreased ovarian reserve
NING Yan-hui;SHEN Ru-meng;XU Chang-juan
Objective
To investigate the clinical effect of Fuke Zaizao Capsules in the treatment of decreased ovarian reserve.
Methods
Sixty patients with decreased ovarian reserve from January 2016 to June 2017 in our hospital were selected as research objects.According to the different treatment methods,the patients were divided into the research group and the control group,with 30 cases in each group.In the research group,Fuke Zaizao Capsules in oral administration was given (6 granules each time,twice per day,and took them one week before menstruation for 15 consecutive days,for three courses of treatment),and in the control group,artificial cycle alone was used.The serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E
2
),anti-Mullerian hormone(AMH)levels were compared between the two groups before and after treatment.The vaginal ultrasound test was performed to compare ovarian volume,endometrial thickness,number of ovarian sinus follicles between the two groups before and after treatment,and the treatment effect was compared between the two groups.
Results
There were no significant differences in the levels of FSH,LH,FSH/LH,E
2
and AMH between the two groups before treatment(P＞0.05).The levels of FSH,LH and FSH/LH after treatment in the two groups were lower than those before treatment,the levels of E
2
and AMH were higher than those before treatment,and the differences were statistically significant(P＜0.05).The levels of FSH,LH and FSH/LH after treatment in the research group were lower than those in the control group,the levels of E
2
and AMH after treatment were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in ovarian volume,endometrial thickness,and number of ovarian sinus follicles between the two groups before treatment(P＞0.05).The ovarian volume and endometrial thickness after treatment in the two groups were larger than those before treatment,the number of ovarian sinus follicles was higher than that before treatment,and the differences were statistically significant(P＜0.05).The ovarian volume and endometrial thickness after treatment in the research group were larger than those in the control group,the number of ovarian sinus follicles was higher than that in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of treatmen in the research group was 93.33%,which was significantly higher than that in the control group (76.67%),and the difference was statistically significant(P＜0.05).
Conclusion
The Fuke Zaizao Capsules obtain a good clinical effect in treating patients with decreased ovarian reserve,which can improve the endocrine status as well as the ovarian reserve of patients.
2019 Vol. 26 (5): 123-126 [
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121
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127
Effect of focused ultrasound in the treatment of chronic cervicitis
XIONG Xia-si
Objective
To investigate the effect of focused ultrasound in the treatment of chronic cervicitis.
Methods
A total of 89 patients with chronic cervicitis admitted to department of gynecology of our hospital from January 2016 to June 2018 were selected as research objects.According to the random number table method,they were divided into the observation group (45 cases)and the control group (44 cases).The patients in the observation group were treated with focused ultrasound and those in the control group were treated with microwave therapy.The operation time,blood loss,clinical treatment effect and complications were compared between the two groups.
Results
The operation time of the observation group was (7.35±1.95)min,and the amount of bleeding was (6.92±3.28)ml,which were not statistically significantly different from those of the control group of(6.84±1.82)min and(6.38±2.34)ml respectively(P＞0.05).The total effective rate of the treatment of the observation group was 97.78%,which was higher than that of the control group (84.09%),and the difference was statistically significant(P＜0.05).The total incidence rate of complications in the observation group was 13.33%,which was significantly lower than that in the control group (38.64%),and the difference was statistically significant(P＜0.05).
Conclusion
Focused ultrasound has a significant effect in the treatment of patients with chronic cervicitis,with fewer complications,which is worthy of clinical investigation.
2019 Vol. 26 (5): 127-129 [
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80
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130
Observation of effect of laparoscopic surgery in the treatment of pregnancy at the uterine scar after cesarean section
XU Guang-hui
Objective
To study the effect of laparoscopic surgery in the treatment of pregnancy at the uterine scar after cesarean section.
Methods
A retrospective analysis was made of the clinical data of 100 cases of uterine scar pregnancy after cesarean section in our hospital from January 2015 to January 2016.According to the different treatment methods,the patients were divided into control group and research group,50 cases in each group.The control group was treated with medication,while the research group was treated with laparoscopic surgery.The total effective rate of treatment,operation time,intraoperative bleeding volume,hospitalization time,uterine recovery time and blood human chorionic gonadotropin(β-HCG)decrease to normal time were compared between the two groups.
Results
The total effective rate of treatment in the research group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The operation time,intraoperative bleeding volume,hospitalization time,uterine recovery time and blood β-HCG decrease to normal time in the research group were significantly shorter than those in the control group,intraoperative bleeding volume was significantly less than that in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Laparoscopic surgery is effective for pregnant women with uterine scar after cesarean section.It can effectively shorten the operation time,hospitalization time,uterus return to normal time,blood β-HCG decrease to normal time and reduce the amount of intraoperative bleeding.It should be widely used in the clinic.
2019 Vol. 26 (5): 130-132 [
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83
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133
Effect of functional inferior turbinate plasty under nasal endoscope on chronic hypertrophic rhini
WANG Rong-bing;TAN Si-min;MO Jian-ying;ZHOU Can-lu;CHEN Ying-yan;XIE Jian-sheng;LIN Hui-shen
Objective
To investigate the effect of functional inferior turbinateplasty under nasal endoscope in the treatment of chronic hypertrophic rhinitis.
Methods
A total of 100 patients with chronic hypertrophic rhinitis admitted to our hospital from January 2015 to December 2016 were enrolled in the study group.Based on different surgical methods,the patients were divided into study group and control group,50 cases in each group.In the control group,partial turbinate resection under nasal endoscope was performed,while in the study group,functional inferior turbinateplasty under endoscope was adopted.The surgical related indexes,surgical results and postoperative complications were compared between the two groups.
Results
The total effectiveness rate of the study group was not different from that of the control group at one month after operation (P＞0.05).The total effectiveness rate of the study group was superior to that of the control group 6 and 12 months after operation(P＜0.05).The operation time and edema time were both shorter in the study group than that in the control group(P＜0.05).The nitric oxide(NO)and C-reactive protein(CRP)indexes in the study group were lower than those in the control group (P＜0.05).The blood loss in the study group was lower than that in the control group (P＜0.05).The visual analog scale(VAS)of nasal resistance scores and total nasal resistance measurements were not different from the control group before surgery and one month after surgery (P＞0.05).While 6 and 12 months after surgery,the VAS of nasal resistance and total nasal resistance measurements were lower than those in the control group (P＜0.05).The incidence of postoperative complications in the study group was lower than that in the control group (P＜0.05).
Conclusion
Compared with the treatment of partial inferior turbinate resection,the longterm effect of endoscopic functional inferior turbinateplasty for chronic hypertrophic rhinitis is better,and the incidence of postoperative complications is lower,which can effectively improve the quality of life of patients.
2019 Vol. 26 (5): 133-136 [
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83
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137
Clinical observation of lipid layer changes in diabetic patients with dry eye
HE Jing
Objective
To determine the lipid layer thickness and its fluctuation and the incomplete blink rate of patients with type 2 diabetes (T2DM)and non-diabetes.
Methods
A total of 46 patients with T2DM with 92 eyes were selected as diabetic group,and 45 patients with non-diabetes with 90 eyes were selected as non-diabetic group.Two groups of patients are measured respectively on break-up time(BUT),tear secretion testⅠ (SchimerⅠtest),corneal fluorescein staining(FL),Rapid dry eye assessment questionnaire,the lipid layer thickness by Lipiview ocular surface Interferometry and its volatility and incomplete blink rate and determination.
Results
The OSDI of the diabetic group was(47.88±17.51)point,which was higher than that of the non-diabetic group (38.76±12.62)point,and the difference was statistically significant(P＜0.05).The Sit of the diabetic group was(3.88±1.38)mm,which was lower than that of the non-diabetic group(6.17±2.50)mm,the difference was statistically significant(P＜0.05).BUT was(2.89±0.43)s,which was lower than that of the non-diabetic group (4.91±1.54)s,the difference was statistically significant(P＜0.05).The staining of the corneal fluorescein score of the diabetic group was(1.97±0.93)score,which was higher than that of the non-diabetic group (1.38±0.62),and the difference was statistically significant(P＜0.05).The lipid layer thickness of the diabetic group was(45.24±6.22)nm,which was less than that of the non-diabetic group(57.57±6.26)nm,and the lipid layer thickness of the diabetic group was less than that of the non-diabetic group,the difference was statistically significant(P＜0.05).
Conclusion
Diabetic patients are compared with normal patients,which show different degrees of reduction in tear base secretion and lipid layer thickness,that also provide the basis for clinical detection and treatment of diabetic patients.
2019 Vol. 26 (5): 137-139 [
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125
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140
Comparison of the effect of dental implant repair and routine repair in the treatment of dentition loss
LI Jun
Objective
To analyze the effect of dental implant repair and routine repair in the treatment of dentition loss.
Methods
From February 2015 to February 2017,60 cases of dentition loss in our hospital were selected as the research object.All the subjects were divided into observation groups (n=30)and control group (n=30)according to random number table method.The control group was treated by routine repair therapy,and the observation group was treated with dental implant repair.The satisfaction degree of the two groups of patients after repair and the effect of clinical repair were compared.
Results
The total effective rate of the observation group(96.67%)was significantly higher than that of the control group(70.00%).The difference was statistically significant(P＜0.05).The scores of language function,masticatory function,retention function,comfort and aesthetics in the observation group were significantly higher than those in the control group,with statistically difference (P＜0.05).
Conclusion
In the treatmentof dentition loss,the method of implantation and repair is better for the treatment of dentition.It is helpful to improve the patient′s satisfaction with the oral function,masticatory function,retention function,comfort,beauty and so on after the dentition repair.It is worthy of further popularization and application in clinical practice.
2019 Vol. 26 (5): 140-142 [
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81
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143
Comparison of the effect of BL-hot gum vertical compression combined with cold gum lateral compression method and simple hot gum vertical compression method in filling root canal
ZHANG Yun-qing;YANG Zhi-xiong;WANG Li-fang
Objective
To explore the difference of root canal strength between vertical compression of Korean BL gutta gum combined with cold gutta percha lateral compression method and warm gutta percha vertical compression method.
Methods
113 patients who admitted to our hospital from May 2015 to July 2017 were selected and divided into observation group(57 cases,73 root canals)and control group(56 cases,70 root canals)according to random number table method.The control group was treated with hot gutta-percha vertical compression for root canal filling.The observation group used Korean BL hot gum vertical compression combined with cold gum lateral compression,the filling rate and clinical effect of the two groups were analyzed and compared.
Results
The clinical error of the observation group was less than that of the control group,the correct filling rate of the affected teeth in the observation group (98.63%)was significantly higher than that in the control group (84.29%),the differences were statistically significant(P＜0.05),the success rate of the observation group(98.63%)was significantly higher than that of the control group after one year follow-up.The difference was statistically significant(P＜0.05).
Conclusion
The root canal filling with Korean BL hot gum vertical compression combined with cold gum lateral compression can obviously reduce the operation error and increase the filling rate.The clinical effect is remarkable and suitable for clinical application.
2019 Vol. 26 (5): 143-145 [
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] (
82
)
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146
Clinical effect of Minocycline Hydrochloride Ointment and Metronidazole Gel combined with Vitapex in the treatment of combined periodontal endodontic lesions
YU De-chen
Objective
To study the clinical effect and drug application value of Minocycline Hydrochloride Ointment,Metronidazole Gel combined with Vitapex in the treatment of periodontal pulp combined lesions.
Methods
From March 2015 to March 2018,68 patients with combined periodontal and pulpal lesions were selected as the subjects.The patients were divided into the control group (n=34)and the analysis group (n=34)according to random number table method.The control group was treated with conventional periodontal therapy and root canal therapy,and the other special drugs were not given.The analysis group was treated with Minoxycycline ointment and Metronidazole Gel combined with Vitapex paste.After three months of treatment,the therapeutic effects of the two groups were evaluated.
Results
The total effective rate was 94.12%in the analysis group,which was significantly higher than 79.41%in the control group(P＜0.05).There was no significant difference in the depth of exploration(PD),bleeding index(BOP),gingival index(GI)and plaque index (PLI)between the two groups before treatment(P＞0.05),but the indexes in the analysis group after treatment were better than those in the control group (P=0.024).
Conclusion
The therapeutic effect of Minocycline Hydrochloride Ointment and Metronidazole Gel combined with vitapex paste for the patients with periodontal pulp and pulp combined with disease is significant and has high clinical application value.It should be widely popularized in clinical practice.
2019 Vol. 26 (5): 146-148 [
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103
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149
Effect analysis of cold light whitening system on discolored teeth Analysis of the effect of cold-light whitening system in the treatment of discolored teeth
LU Wei-hua;WANG Ru;LI Yan;LAI Hua
Objective
To explore the clinical effect of cold light whitening system of teeth in the treatment of discolored teeth.
Methods
A total of 62 cases of patients with discolored teeth who admitted Ganzhou Weihua Stomatological Hospital,Jiangxi Province from July 2015 to July 2016 were selected and treated with cold light whitening system.The results before and after treatment were compared.
Results
62 patients with endogenous discolored teeth had an average elevation of 10 levels,the total effective rate was 95.00%.The total effective rates of aging discolored teeth(100.00%),fluorosis teeth(100.00%)was higher than those in the tetracycline teeth(82.35%),the difference was statistically significant(P＜0.05).Aging discoloration teeth and fluorosis teeth whitening effect were the best,tetracycline teeth whitening effect were poor.No irreversible pulpitis,photoinduced ophthalmia and dermatitis,and no gingival and soft tissue damage occurred in 62 patients.Only 2 patients with dental fluorosis developed mild sensitivity (3.33%),and symptoms disappeared after treatment.
Conclusion
The treatment of discolored teeth by cold light whitening system is characterized by simple operation,short treatment time,obvious whitening effect,safety and less adverse reactions,which is worthy of clinical application.
2019 Vol. 26 (5): 149-151 [
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] (
84
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152
Effect of phacoemulsification pre-chopping technique on corneal endothelium in PACG patients with cataract
XIANG Jin-jin;YU Ai-min
Objective
To analyze the effect of phacoemulsification pre-chopping technique on visual acuity and corneal endothelial cell injury in patients with primary angle-closure glaucoma(PACG)and cataract.
Methods
40 patients with PACG and cataract who came to our hospital from November 2013 to March 2017 were selected and divided into two groups according to the patients′wishes of treatment,the traditional super-milk group（19 cases） and the super-milk pre-chopping group（21 cases）.Traditional super-milk group was used in the traditional super-breast surgery.The super-breast pre-chopping nucleus group applied pre-chopping technology on the basis of traditional super-breast surgery,followed up the patients of the two groups 1,3 and 7 day after surgery,and told them to go back to the hospital for review one month after treatment.The visual acuity difference,corneal endothelial cell density and hexagonal cell ratio before and after operation were observed and compared between the two groups.
Results
There was no significant difference in preoperative vision,intraocular pressure,corneal endothelial cell density and hexagonal cell ratio between the two groups before surgery (P＞0.05).There was no statistical difference in visual acuity between the two groups at 1 and 3 d after surgery (P＞0.05).However,7 days after surgery,the best visual acuity of the patients in the pre-chopping group was significantly higher than that in the conventional group,and the difference was statistically significant(P＜0.05).There was no statistical difference in intraocular pressure between the two groups at 1 and 3 d after surgery (P＞0.05).However,the intraocular pressure of the patients in the pre-chopping group was significantly lower than that in the conventional group 7 days after surgery (P＜0.05).There was no statistical difference in corneal endothelial cell density between the two groups 1 and 3 d after surgery (P＞0.05).The corneal endothelial cell density in the pre-chopping nucleus group of Zhou Chao milk after surgery was higher than that in the conventional super-emulsion group,the difference was statistically significant(P＜0.05).There was no statistical difference in the percentage of hexagonal cells between 1 and 3 d after surgery(P＞0.05).The percentage of hexagonal cells in the pre-chopping group was higher than that in the conventional group 7 d after surgery and the difference was statistically significant(P＜0.05).There was a statistically significant difference in the types of drugs used to reduce intraocular pressure in the outpatient clinic 1 month after surgery compared with that before surgery (P＜0.05).
Conclusion
Phacoemulsification combined with intraocular lens implantation for patients with PACG complicated with cataract can reduce the influence of traditional phacoemulsification on corneal endothelium,and the postoperative visual acuity can recover quickly,which is worthy of clinical promotion.
2019 Vol. 26 (5): 152-155-173 [
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89
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Study on the relationship between visual acuity，arc spot area and axial length and macular degeneration in patients with high myopia
DUAN Song-lan;DU Dong-ju;LI Yao-ting
Objective
To analyze the relationship between visual acuity,arc spot area and axial length of macular lesions in patients with high myopia.
Methods
From March 2017 to March 2018,100 patients with high myopia were selected as object of study;and the determination of high myopia fundus lesions,the observation and calculation of arc plaque morphology,and the detection of arc plaque type were performed.The relationship between visual acuity,arc spot area and axial length and macular degeneration.
Results
The results of this study showed that the visual acuity was negatively correlated with macular degeneration（r=-0.597）.The lower the visual acuity level,the more serious the macular lesion was.The larger the arc-shaped macular area,the more serious the macular lesion was.The two were positively correlated （r=0.611）.The longer the eye axis was,the more serious the macular lesion was,the two were positively correlated （r=0.587）,the differences were statistically significant(P＜0.05).
Conclusion
The visual acuity,arc spot area and axial length of patients with high myopia are significantly correlated with macular degeneration.It can be used as an important index to evaluate,analyze and prevent high myopia macular degeneration.
2019 Vol. 26 (5): 156-158 [
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80
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159
Comparison of the effect of all-ceramic restoration and composite resin in the restoration of maxillary anterior teeth
HUANG Fen
Objective
To compare the effect of all-ceramic restoration and composite resin in the restoration of maxillary anterior teeth defects.
Methods
104 patients with maxillary anterior teeth defect treated in our hospital from November 2014 to July 2018 were selected and divided into resin group(n=52)and all-ceramic group(n=52)according to different restoration methods.The resin group was filled with composite resin,and the all-ceramic group was restored with all-ceramic crown.The repairing effect,complications and satisfaction of the two groups were evaluated and compared.
Results
The total effective rate of all-ceramic group was 96.15%higher than that of resin group (82.69%),the difference was statistically significant(P＜0.05);the total complication rate of all-ceramic group was lower than that of resin group,the difference was statistically significant(P＜0.05);the scores of retention function,aesthetics and masticatory function satisfaction of all-ceramic group were significantly higher than that of tree group.Lipid group,the differences were statistically significant(P＜0.05).Dental preparation and treatment cost score was significantly lower than resin group,the differences were statistically significant(P＜0.05).
Conclusion
Compared with composite resin,all-ceramic restoration of maxillary anterior teeth can obtain better restoration effect,better masticatory function and aesthetic effect,and is conducive to the maintenance of periodontal health.The disadvantage of all-ceramic restoration is that a large number of tooth tissues need to be abraded,but the overall application value is higher,which can be based on the clinical defect.Location and area to choose the appropriate way of repair.
2019 Vol. 26 (5): 159-161 [
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83
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162
Clinical effect of balloon dilatation of eustachian tube on chronic recurrent secretory otitis media
LI Hong-bin
Objective
To investigate the clinical effect of balloon dilatation （PTCA）of eustachian tube on chronic recurrent secretory otitis media.
Methods
A total of 100 patients with chronic recurrent secretory otitis media from January 2016 to January 2018 were enrolled in the hospital.By an odd/even numbering,they were divided into control group (tympanic membrane catheterization)and observation group (Eustachian PTCA),50 cases in each group.The clinical effect of the two groups was compared.
Results
The Valsalva,airway hearing threshold,total incidence of complications,eustachian dysfunction scores 1,3，and 6 months after operation were lower than those in the control group(P＜0.05).The airway hearing threshold and total effectiveness rate in the observation group were higher than those the control group (P＜0.05).The time of effusion disappearance and tinnitus disappearance,the healing time of tympanic membrane,and the time of hearing returning to normal were shorter than those of the control group,the differences were statistically significant(P＜0.05).
Conclusion
For chronic recurrent secretory otitis media,eustachian PTCA can obtain a remarkable effect.
2019 Vol. 26 (5): 162-164 [
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93
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165
Application effect of Zirconia roasted porcelain tooth in patients with anterior teeth restoration
WANG Ying-xiang
Objective
To investigate the clinical effect of Zirconium dioxide ceramic tooth in anterior tooth restoration.
Methods
From January 2016 to January 2018,86 patients with anterior tooth restoration were selected as the objects of study.According to the patient′s order,the patients were randomly divided into control group (n=43)and experimental group (n=43).The patients in the control group were treated with Ni-Cr alloy porcelain crown for anterior tooth restoration,while the experimental group were treated with Zirconium dioxide porcelain tooth to repair the anterior teeth.The shape integrity,edge tightness and color change of the two groups were observed,and the gingival index and plaque index of the two groups were analyzed and compared.
Results
After treatment,the complete appearance rate of the patients in the experimental group was higher than that in the control group,and the rate of marginal disassociation was lower than that in the control group (P＜0.05).The incidence of color darkening and the incidence of black neck margin in the experimental group were lower than those in the control group (P＜0.05).There was no significant difference in gingival index and plaque index between the two groups before treatment(P＞0.05).After treatment,the gingival index and plaque index in the experimental group were lower than those in the control group(P＜0.05).
Conclusion
The use of Zirconia roasted porcelain tooth for anterior tooth restoration has good aesthetic effect and good stability,and little influence on gingival,so it is worth popularizing in clinic.
2019 Vol. 26 (5): 165-167 [
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85
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Comparison of endoscopic sinus surgery and traditional surgery in the treatment of chronic sinusitis and nasal polyps
ZHANG Hui-yong
Objective
To compare the effect of endoscopic sinus surgery and traditional surgery in the treatment of chronic sinusitis and nasal polyps.
Methods
Seventy patients with chronic sinusitis and nasal polyps admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into experimental group and control group,35 cases in each group.The control group was treated with traditional surgical methods,endoscopic nasal surgery was used in the experimental group.The clinical effects,complications and symptom scores were compared between the two groups.
Results
The total effective rate of the experimental group was higher than that of the control group,and the total incidence of complications was lower than that of the control group(P＜0.05).The clinical symptom score of the experimental group was lower than that of the control group,the differences were statistically significant(P＜0.05).
Conclusion
Endoscopic sinus surgery can effectively treat the symptoms of chronic sinusitis and nasal polyps,and has achieved good results in clinical practice.It has certain advantages over traditional surgical methods.This method is worth popularizing in clinical medicine.
2019 Vol. 26 (5): 168-169-195 [
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96
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Effect of different administration routes of Dexamethasone on the treatment of sudden deafness
CAI Lan-yu
Objective
To observe the dosage Dexamethasone different influence on the curative effect of patients with sudden deafness.
Methods
From June 2015 to June 2018,60 cases of patients with sudden deafness were selected,they were divided into the control group and the observation group according to random number table method,30 cases in each group.Ears after injection of Dexamethasone treatment in combination with the control group using conventional therapy,observation group with the same routine therapy combined with drum indoor injection of Dexamethasone treatment,both groups on injection,injection of 5 times.Before and after treatment on two groups of patients with pure tone hearing threshold test(PTA),calculate the average valve;Observe two groups of patients with curative effect,adverse reaction and negative emotions;the two groups after treatment of quality of life were compared.
Results
The total effective rate observation group in was 83.33%,60.00%higher than that of control group,the difference was statistically significant(P＜0.05).An average of the two groups after treatment to listen to valve down,compared with before treatment and observation group,on average,to listen to valve was lower than the control group after treatment,the difference was statistically significant(P＜0.05).The incidence of adverse reactions the two groups between,there was no statistically significant difference(P＞0.05).Self-evaluation of the two groups after treatment of anxiety scale(SAS)and depression self rating scale (SDS)score was decreased,the score was lower than the control group after treatment and observation group,the difference was statistically significant(P＜0.05).After the intervention,health survey profiles(SF-36)score in the observation group were higher than the control group,the difference was statistically significant(P＜0.05).
Conclusion
Dexamethasone drum the ears after injection injection can more effectively improve the symptoms of patients with sudden deafness hearing,alleviate patients′negative mood,improve patient quality of life.
2019 Vol. 26 (5): 170-173 [
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103
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Effects of ultrasound-guided transversus abdominis plane block on postoperative outcome of patients undergoing open abdominal surgery
SHI Li;LIU Shi-wen;LI Hong;ZHONG Sheng-hong
Objective
To observe the effects of ultrasound-guided transversus abdominis plane block (TAPB)on postoperative outcome of patients undergoing open abdominal surgery.
Methods
A total of 60 patients who underwent laparotomy in our hospital from October 2017 to October 2018 were selected as the study subjects,and they were divided into group T(30 cases)and group C(30 cases)according to random number table method.TAPB and patient-controlled intravenous analgesia(PCA)were performed after operation in group T.PCA was performed after operation in group C.Pain visual analogue scale (VAS),Bruggrmann comfort scale(BCS),PCA compression times,satisfaction degree and postoperative complications at different time points were compared between the two groups.
Results
VAS score in group T was significantly lower than in group C at 2,4,6,8 and 12 hours (P＜0.05),and BCS score was significantly higher than in group C (P＜0.05).At 24 hours in group T and group C,VAS BCS scores were not statistically significant(P＞0.05).Times of pressing analgesia pump in group C was higher than in group T (P＜0.05),and satisfaction degree in group T was higher than in group C (P＜0.05).There were no significant differences in incidence of nausea,vomiting and respiratory depression between group T and group C(P＞0.05),and no complications of TAPB were observed in group T.
Conclusion
TAPB is consistent with precise anesthesia and enhanced recouery after surgery.It provides effective analgesic for open abdominal patients and positive impacts on the prognosis of abdominal surgery.It is worthy of promoting in clinical.
2019 Vol. 26 (5): 174-176 [
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79
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177
Effect of accelerated rehabilitation surgery on postoperative cognitive function of elderly patients with lumbar disc herniation
HUANG Dao-li;ZHU Guan-nan;OU Guang-xin;XIAO Qing-hua;QIU Wei-dong
Objective
To discuss the enhanced recovery after surgery(ERAS)concept in improving the cognitive function after spinal surgery in elderly patients.
Methods
120 elderly patients with lumbar intervertebral disc herniation who underwent surgical treatment in our hospital from July 2016 to June 2018 were selected for this research.They were divided into the experimental group and the control group according to the random number table method,60 patients in each group.ERAS concept were administered in the experimental group and routine perioperative measures were administered in the control group.Patients were given a simple mental status scale(MMSE)score at 12 h before surgery and 12,24 and 48 after surgery,and visual analogue scale(VAS)and sedation(Ramsay)score at 4,8,24 and 48 h after surgery.
Results
The MMSE score of preoperative 12 h the experimental group and the control group showed no significant difference (P＞0.05).The MMSE score of 12,24 and 48 h postoperative in the experimental group were higher than those in the control group,with statistically significant differences (P＜0.05).Postoperative 72 h MMSE score in the experimental group showed no significant difference (P＞0.05).The VAS scores of postoperative 4,8,24 and 48 h in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Postoperative scores of the experimental group at 4,8,24 and 48 h VAS were lower than those of the control group,with statistically significant differences (P＜0.05).
Conclusion
ERAS treatment scheme can improve the postoperative cognitive function in patients with lumbar disc,but ERAS tactics in specific measures and the relationship between postoperative cognitive function remains to be further study,its specific mechanism remains to be further discussed.
2019 Vol. 26 (5): 177-180 [
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94
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181
Comparison of sedation effects of Dexmedetomidine or Midazolam combined with Sufentanil in patients undergoing invasive mechanical ventilation
ZHANG Yan;SU Xiao-lei;ZHAO Rui;ZHU Hong;FANG Kai-yu
Objective
To explore the sedative effect of Dexmedetomidine or Midazolam combined with Sufentanil in invasive mechanical ventilation.
Methods
Selected 102 patients with invasive mechanical ventilation in our hospital from June 2017 to June 2018,according to random number table method,they were divided into control group and observation group,51 cases in each group.The control group was sedated by Midazolam combined with Sufentanil,while the observation group was sedated by Dexmedetomidine combined with Sufentanil.The mechanical ventilation time,awakening time,ICU time and adverse reactions were compared between the two groups.Ramsay score,heart rate(HR),mean arterial pressure(MAP)and blood oxygen saturation(SpO
2
)were monitored before and 6,12 and 24 hours after treatment.
Results
The mechanical ventilation time and wake-up time in the observation group were shorter than those in the control group (P＜0.05),but there was no statistical difference between the two groups when they were living in ICU(P＞0.05);the total incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05).The levels of HR and MAP in the two groups at 6,12 and 24 h after treatment was lower than those before treatment,the spO
2
level increased,and HR and MAP in the observation group were lower than those in the control group,SpO
2
level was higher than that of control group (P＜0.05).The Ramsay scores of the two groups at 6,12 and 24 hours after treatment was higher than those before treatment,and that of the observation group was higher than that of the control group (P＜0.05).
Conclusion
Dexmedetomidine combined with Sufentanil for invasive mechanical ventilation patients can achieve good sedative effect,stabilize the vital signs of patients,and have fewer adverse reactions.
2019 Vol. 26 (5): 181-183-202 [
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93
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184
Investigation on the status quo of fertility preservation of College Students in Anhui Province
JI Dong-mei;XU Juan;LUO Yuan;YANG Han-chen;WANG Xue-qing;WANG Zhi-yu
Objective
To questionnaires related to fertility preservation,the present situation of fertility preservation of college students in Anhui Province is thoroughly understood.
Methods
From April 2 to July 19,2018,the survey on fertility preservation of college students was conducted in nine colleges and universities in anhui province,the data were classified and compared according to sex,specialty and whether or not the only child was born.
Results
A total of 231 questionnaires were sent out,and 200 qualified questionnaires were recovered,the qualified rate was 86.58%.The proportion of sexual life history among college students in Anhui Province is low (only 18.70%-41.65%),but most of them take active contraceptive measures(74.03%-93.88%).The majority of students have the willingness to have children after marriage (73.98%-88.31%),and their planned reproductive age is concentrated in 27-29 years(53.25%-73.17%).College students attach more importance to infertility and infertility.They have a higher awareness of the decline in fertility(60.00%-95.00%).Most of them are willing to accept fertility preservation measures(66.67%-74.03%).Classification comparison:boys had more sexual life history,girls and science students preferred to have children between 27 and 29 years old.Among them,girls paid more attention to the"old age"factor,while only children paid more attention to the"abortion"factor,the differences between the above classifications were statistically significant(P＜0.05).
Conclusion
College students in Anhui Province have a better overall understanding of fertility preservation,but the planned reproductive age is somewhat older.
2019 Vol. 26 (5): 184-186-205 [
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90
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187
Analysis of distribution and drug resistance of common pathogens in our hospital
OU Huan-jiao;XIANG Rong
Objective
To analyze the distribution and drug resistance of common pathogenic bacteria in grass-roots hospitals,so as to provide reference and basis for rational use of antibiotics in clinic.
Methods
The distribution of pathogenic bacteria isolated in our hospital from 2012 to 2017 was retrospectively analyzed,and the drug resistance of the main Gram-positive bacteria and the main Gram-negative bacteria were analyzed.
Results
Clinical isolation of pathogenic bacteria 22 191 strains,5268 strains of Gram-positive bacteria (23.74%),14 494 strains of Gram-negative bacteria(65.31%)and 2429 strains of Fungi(10.95%).The clinical detection rate of Methicillin-resistant Staphylococcus aureus(MRSA)increased year by year from 2012 to 2015.Escherichia coli and Klebsiella pneumoniae,two non-ESBLs-producing enterobacteriaceae,are relatively sensitive to commonly used antibiotics in our hospital.There are differences in drug resistance rates and trends between ESBLs-producing and non-ESBLs-producing enterobacteriaceae.
Conclusion
From 2012 to 2017,Gram-negative bacteria were the main pathogenic bacteria in clinical isolation.In clinical treatment,antibiotics could be adjusted according to the characteristics of bacterial epidemiology and the susceptibility test of bacteria.Or rational use of antibiotics based on bacterial drug sensitivity test to curb bacterial resistance.
2019 Vol. 26 (5): 187-190 [
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75
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191
Psychological relasticity of knee osteoarthritis patients in old age institutions and its influence factors
LI Shuai-miao;YANG Zhi-lan; XU Juan
Objective
To investigate the psychological relasticity of knee osteoarthritis patients in old age institutions and its influence factors.
Methods
Convenience sampling method was used,150 KOA patients from two pension institutions which the same size and condition in Taiyuan,Shanxi were selected as the subjects from March to July 2018.Psycho-elasticity scale（CD-RISC）,concise pain scale(BPI),pain self-efficacy questionnaire(PSEQ),geriatric depression scale and self-designed general information questionnaire were used to investigate them.
Results
A total of 142 valid questionnaires were collected,with an effective recovery rate of 94.67%.The total score of KOA elderly people was(60.62±12.65)points.It was lower than the norm(65.40±13.90)points(P＜0.05).Pain self-efficacy score was(36.66±10.91)points.It was positively correlated with psychological resilience(r=0.875,P＜0.001)and toughness(r=0.804,P＜0.001),self-reliance(r=0.779,P＜0.001),optimism(r=0.394,P＜0.001)of KOA patients in.old age institutions Number of children,the frequency of visiting the elderly to relatives and friends,emotional state and pain self-efficacy were the influencing factors of psychological resilience of KOA patients (P＜0.05),which explained 79.7%of the variation of psychological resilience.
Conclusion
Medical staff in old-age institutions should pay attention to the psychological problems of KOA patients,and carry out targeted psychological intervention and support,so as to improve the psychological resilience level of KOA patients.
2019 Vol. 26 (5): 191-195 [
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100
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196
Analysis of the causes and influencing factors of functional dyspepsia in secondary vocational school students
TAN Qiao-mei;LI Wen-feng;YE Xiu-na;LU Yun-xiang;XU Chao-long
Objective
To analysis of the causes and influencing factors of functional dyspepsia（FD）in secondary vocational school students.
Methods
A total of 3942 cases secondary vocational school students admitted to Yangjiang Health School from August 2014 to January 2019 were selected,Questionnaire survey and analysis of all students in school,univariate analysis and multivariate Logistic regression analysis were used to analyze the etiology.
Results
①3942 secondary vocational school students suffered from FD 466 cases,accounting for 11.82%,non-functional dyspepsia 3476 cases,accounting for 88.18%;②Univariate analysis showed that sex， dietary hygiene habits,tea drinking,frequent medication， Rational use of diet pills and punctual meals were associated with functional dyspepsia(P＜0.05);③Multivariate Logistic regression analysis showed that sex,picky eating,drinking tea,taking medicine frequently，rational use of diet pills and punctual meals were risk factors for FD (P＜0.05).
Conclusion
Secondary vocational school students have a higher incidence of FD,sex,picky eating,drinking tea,taking medicine regularly and punctual meals were all possible causes of the disease.Reasonable prevention and treatment measures should be formulated according to the causes.
2019 Vol. 26 (5): 196-198 [
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72
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199
Non-Cochrane systematic reviews and meta-analysis on ophthalmology published in SCI Journals
SONG Jian;ZHANG Li-jun;LIU Xin
Objective
To investigate the present situation of non-Cochrane systematic reviews and Meta-analysis published in the field of ophthalmology.
Methods
PubMed and EMBASE database were searched by their intelligent search function to find systematic reviews and Meta-analysis in the field of Ophthalmology up to 30 January 2017.Duplicate researches and Cochrane systematic reviews were excluded by Endnote software.Irrelevant studies were excluded by reading titles,abstracts and full text.The final included studies were classified according to author′s source,publication years,study types and so on.
Results
A total of 10 369 records were identified.After excluding Cochrane systematic reviews(882),duplicated studies(1586)and unrelated studies(6480),1421 studies were included in the final analysis.The classification analysis to be included in the study showed that authors came from 53 countries participated in the publication of these articles.The top three countries were China(441,31.03%),USA(229,16.12%)and UK(204,14.36%).A total of 433 different journals published these studies,and the top three journals were PLoS One(102,7.18%),Ophthalmology(97,6.83%),and Br J Ophthalmol(57,4.01%).The top three diseases were retinal disease(463,32.58%),glaucoma(226,15.90%)and cataract(120,8.44%).Qualitative study accounted for a large proportion(548,38.56%),and the remainder were quantitative studies(873,61.44%),the latter included 411 interventional studies(47.08%)and 462 observational studies(52.2%).
Conclusion
The amount of systematic reviews and meta-analysis in the field of ophthalmology has been increased year by year,and more and more authors coming from different countries are actively participating in this field,especially in China.Retinal disease and glaucoma are still the focus of the current study.With the gradual increase of high-quality clinical evidence for ophthalmology,they will provide a strong and effective guidance for the diagnosis and treatment of eye diseases.
2019 Vol. 26 (5): 199-202 [
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104
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203
Follow-up evaluation of cervical cancer screening among married female workers in enterprises
CHEN Ya-li
Objective
To evaluate and analyze the follow-up of cervical cancer screening among married female workers in enterprises.
Methods
In this study,married female employees who came to our hospital for gynecological diseases from January to December in 2017 were selected as subjects.They were performed with cervical cytology.The results were positive ASC-US and above in those patients who were followed up and their outcomes were calculated and evaluated.
Results
Of the 4350 married female employees,71 were positive accounting for 1.63%.The re-examination rate of positive patients was 94.4%,of which HPV combined with cervical biopsy under colposcope was the most common accounting for 54.93%.After re-examination,the proportion of CIN and above was 45.07%.
Conclusion
After screening cervical cancer for married female employees,re-examination and regular follow-up of those with positive results are beneficial for the improvement of the health in female workers and prevent cervical cancer.
2019 Vol. 26 (5): 203-205 [
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82
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206
Application effect of combined predictive and stage-based nursing on elderly patients with proximal femoral fracture
BAI Li;YANG Jin;WANG Ling
Objective
To study and analyze the clinical application value of predictive and stage-based nursing for elderly patients with proximal femoral fractures.
Methods
A total of 60 patients with proximal femoral fractures received in the First Affiliated Hospital of Jiangxi Medical College from September 2016 to January 2018 were selected as subjects and were divided into two groups according to the computer random method,30 cases in each group.The control group were treated with orthopedic routine nursing mode.Patients in the observation group received combined predictive and stage-based nursing on the basis of orthopedic routine nursing mode.The quality of life and complications were compared between the two groups.
Results
The quality of life score of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
The combined predictive and stage-based nursing care for patients with proximal femoral fractures can improve the compliance of nursing and the function of the hip joint,and it is worthy of wide clinical application.
2019 Vol. 26 (5): 206-208 [
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87
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Effect of holistic nursing on mental status and coordination of children undergoing surgery
FU Yun-juan
Objective
To explore the effect of holistic nursing on the psychological state and coordination of children undergoing surgery.
Methods
Retrospective analysis was performed on the nursing status of 70 cases of children receiving surgical treatment in our hospital from April 2015 to May 2016.According to different nursing methods,the patients were divided into observation group and control group,with 35 cases in each group.The control group received routine nursing intervention,and the observation group received holistic nursing intervention on the basis of routine nursing.The Self-rating depression scale(SDS)score and Hamilton anxiety scale(HAMA)score before and after nursing,and degree of adaptability after nursing of the two groups were observed and compared.
Results
The SDS score of the observation group was(58.62±2.61)points,the HAMA score was(6.85±0.76)points,both were lower than those of the control group ([65.84±2.12]points and [7.23±0.78]points),the differences were statistically significant(P＜0.05).The SDS score and HAMA score of the two groups of children after nursing were lower than those before nursing,and the difference was statistically significant(P＜0.05).The degree of cooperation in the observation group was 94.28%,significantly higher than that in the control group (68.57%),and the difference was statistically significant(P＜0.05).
Conclusion
Holistic nursing care for children undergoing operation can improve the mental state of children and improve their coordination.It is worthy of clinical application and popularization.
2019 Vol. 26 (5): 209-211 [
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90
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212
Application of foam dressing in prevention of nasal pressure sore in patients with non-invasive ventilation in respiratory department
ZHONG Chen-xi;LIU Jian-ping;LAI Qi-xun;YU Yuan
Objective
To explore the application value of foam dressing in the prevention of nasal pressure sore in patients with non-invasive ventilation in respiratory department.
Methods
Sixty-two patients who underwent noninvasive ventilator treatment from January to June in 2017 in our hospital were selected as the study subjects.According to different nursing regimens,they were divided into control group(n=31)and observation group(n=31).In the control group,routine nasal care was used,and in the observation group,foam dressing on the basis of the control group was adopted.The incidence of nasal pressure sores,comfort,and quality of life scores were compared between the two groups.
Results
The total incidence of nasal pressure sores in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The total nursing comfort of the observation group was 93.55%,which was significantly higher than that of the control group (70.97%),with a statistical difference (P＜0.05).The quality of life scores of the two groups were higher than those before the intervention,and after the intervention,the quality of life scores in the observation group were significantly higher than those of the control group,the differences were statistically significant(P＜0.05).
Conclusion
For patients with non-invasive ventilator assisted ventilation,foam dressing can greatly reduce the incidence of nasal pressure sores,and improve patient comfort as well as quality of life.It is worthy of further exploration and promotion in the clinic.
2019 Vol. 26 (5): 212-214 [
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89
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215
Application effect of cognitive behavioral therapy in the patients with schizophrenia
ZHU Yan-qing;NIE Sha;DENG Shao-ling;HE Wan-yi
Objective
To investigate the application effect of cognitive behavioral therapy in the patients with schizophrenia.
Methods
A total of 200 patients with schizophrenia during remission who were hospitalized in Hui′ai Hospital of Guangzhou City from June 2014 to March 2016 were enrolled as subjects.According to the different intervention methods,they were divided into control group and study group,with 100 patients in each group.However,during the entire study period,affected by various factors,some patients were withdrawn from the study.The final study group was 92 patients and the control group was 87 patients.The control group was given routine treatment,nursing and health education.The study group was given individual cognitive behavioral therapy interventions based on the control group.Before and after intervention and 3,6,12 months after discharge,led by psychiatrists who received relevant training,the brief psychiatric rating scale(BPRS),the insight and treatment attitude questionnaire(ITAQ),and the self-developed medication compliance survey were used,and the patients′condition,self-knowledge,treatment attitude and medication compliance were assessed respectively.
Results
The scores of BPRS in the study group were significantly lower than those in the control group after intervention and 3,6,12 months after discharge,the differences were statistically significant(P＜0.05).The scores of ITAQ in the study group were significantly higher than those in the control group after intervention and 3,6,12 months after discharge,the differences were statistically significant(P＜0.05).The complete compliance rate to medica-tion of patients in the study group were higher than those in the control group at 3,6 and 12 months after discharge,the differences were statistically significant(P＜0.05).
Conclusion
The application effects of cognitive behavioral therapy in the patients with schizophrenia can effectively improve patients′treatment compliance,and maintain their attitude during treatment,so as to further improve therapeutic effects and enhance patients′clinical symptoms.
2019 Vol. 26 (5): 215-219 [
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96
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220
Application effect of Doula accompanied delivery in natural parturient women
ZHANG Chun-yan;PAN Dong-ying;YU Li-hua
Objective
To analyze the application effect of using guided music to accompany childbirth during the natural delivery process.
Methods
A total of 80 cases of natural parturient admitted to our hospital from June 2017 to April 2018 were randomly selected as research objects and were divided into observation group and reference group by random number table method,with 40 cases in each group.The reference group received routine care,while the observation group was given Doula accompanied delivery.The clinical nursing effects of the two groups were compared.
Results
The pain grading during the incubation period,active period and the second stage of labor of the observation group were better than those in the reference group,the differences were statistically significant(P＜0.05).After the nursing,the self-rating anxiety scale (SAS)of the observation group was (33.53±8.42)points,lower than before nursing([59.14±3.36]points)and reference group ([43.67±7.68]points),the differences were statistically significant(P＜0.05).The total labor duration of the observation group([9.13±1.24]h)was shorter than that of the reference group([11.23±1.12]h),the postpartum blood loss of the observation group ([292.65±67.51]ml)was less than that of the reference group([331.47±39.24]ml),the cesarean section rate of the observation group(12.5%)was lower than that of the reference group(40.0%),the differences were statistically significant(P＜0.05).
Conclusion
In the process of maternal natural childbirth,the use of guided music to accompany childbirth can reduce maternal adverse emotions,shorten the labor process,reduce maternal labor pain and cesarean section rate,and improve maternal and child prognosis.
2019 Vol. 26 (5): 220-222 [
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81
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Application value of psychological nursing for orphaned and disabled children in the welfare institutions
SU Hong-mei
Objective
To discuss the application value of psychological nursing for orphaned and disabled children in the welfare institutions.
Methods
A total of 80 orphaned and disabled children treated from November 2015 to November 2017 in our hospital were selected as subjects.Children were equally assigned to control group (n=40)and observation group(n=40).The control group was treated with the conventional nursing care,the observation group was treated with the psychological nursing interventions.The scores of self-rating anxiety scale(SAS),self-rating fear scale and self-rating fear scale and total effective rate for two groups were compared.
Results
Before intervention,the SAS and self-rating fear scale scores for two groups were not significantly different(P＞0.05);after intervention,the SAS and self-rating fear scale scores for two groups were lower than before intervention,the differences were statistically significant(P＜0.05);the SAS and self-rating fear scale scores in the observation group were significantly lower than those in the control group,the differences were statistically significant(P＜0.05);the total effective rate in the observation group(95.00%)was significantly higher than that in the control group(77.50%),the difference was statistically significant(P＜0.05).
Conclusion
The psychological nursing rehabilitation can remarkably relieve their anxiety and fear,improve the life quality and increase the whole nursing effect.It shall be applied in the welfare institutions.
2019 Vol. 26 (5): 223-225 [
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91
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Application effect of psychological nursing intervention in patients with anxiety disorders
LI Shu-ying
Objective
To explore the application effect of psychological nursing intervention in patients with anxiety disorders.
Methods
A total of 90 patients with anxiety disorders admitted to our hospital from January 2017 to April 2018 were enrolled as study subjects.They were divided into control group and experimental group according to different nursing methods,with 45 cases in each group.In the control group,basic nursing service was used,while in the experimental group,basic nursing combined with psychological nursing intervention was adopted.The satisfaction rate,environmental nursing quality score,humanistic care score,nurses′attitude score,Pittsburgh sleep quality score before and after nursing and hypnotic drug utilization rate were compared between the two groups.
Results
The satisfaction rate of patients in the experimental group was higher than that in the control group,the difference was statistically significant(P＜0.05).The scores of environmental nursing quality,humanistic care and nurses′attitude in the experimental group were higher than those in the control group,the differences were statistically significant(P＜0.05).The total scores of Pittsburgh sleep quality were compared between the two groups before nursing,the difference was not statistically significant(P＞0.05).After the nursing,the Pittsburgh sleep quality score of the experimental group was lower than that of the control group,the difference was statistically significant(P＜0.05).The use rate of hypnotic drugs in the experimental group was lower than that in the control group,the difference was statistically significant(P＜0.05).
Conclusion
Basic nursing combined with psychological nursing intervention in anxiety care can obtain a clear effect,which can reduce the use rate of hypnotic drugs,create a great environment for patients,enhance human care,improve the quality of sleep and increase their satisfaction.
2019 Vol. 26 (5): 226-228 [
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100
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Application value of risk prevention nursing in pediatric nursing management
CHEN Kan;XIE Wen
Objective
To explore the value of risk prevention nursing in pediatric nursing.
Methods
A total of 138 cases of patients treated in our hospital from September 2016 to March 2017 were selected as subjects for research and analysis,and were randomly divided into the observation group (n=69)and the control group (n=69)according to the different modes of receiving nursing.Patients in the control group were cared by the traditional pediatric treating service,and others in the observation group were cared using the risk prevention intervention method.The nursing quality score and the total incidence of risk events were compared between the two groups.
Results
After nursing,the nursing quality scores of health,psychology,treatment,life and other aspects in the observation group were all higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of risk events in the observation group(2.90%)was significantly lower than that in the control group(15.94%),and the difference was statistically significant(P＜0.05).
Conclusion
The risk prevention intervention way can improve the patients′quality of rehabilitation and avoid the occurrence of dangerous events.
2019 Vol. 26 (5): 229-231 [
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93
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Applicative effect of nursing intervention in percutaneous nephroscope pneumatic lithotripsy in the treatment of kidney stones
LIU Ying
Objective
To investigate the effect of nursing intervention on the treatment of kidney stones with percutaneous nephrolithotomy pneumatic lithotripsy.
Methods
Sixty patients with kidney stones admitted to our hospital from January 2015 to January 2018 were enrolled in the study.They were divided into experimental group (30 cases)and control group (30 cases)according to double-blind method.Patients in the control group received routine nursing,and patients in the experimental group received nursing intervention.The total nursing satisfaction and quality of life scores were compared between the two groups.
Results
After the nursing,the quality of life score of the experimental group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).After nursing,the total nursing satisfaction of patients in the experimental group was 100.0%,which was higher than that of the control group(66.7%),and the difference was statistically significant(P＜0.05).
Conclusion
Nursing intervention in the treatment of kidney stones by percutaneous nephrolithotomy pneumatic lithotripsy can significantly improve the quality of life of patients and improve the satisfaction of nursing.It is worthy of clinical application.
2019 Vol. 26 (5): 232-234 [
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84
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Application effect of high quality nursing intervention in elderly patients with chronic obstructive pneumonia
CHEN Su-ling;WANG Qiong-ping;HUANG Wen-ting;SU Jie
Objective
To explore the application effect of high-quality nursing intervention in elderly patients with chronic obstructive pneumonia.
Methods
From February 2016 to August 2018,100 elderly patients with chronic obstructive pneumonia treated in Department of Respiratory Medicine of Shenzhen Hospital(Guangming)in University of Chinese Academy of Sciences were selected as study objects and they were divided into the control group (50 cases)and high quality group(50 cases)according to the random number table method.The control group received the routine nursing intervention,while the high quality group received high quality nursing intervention.The nursing satisfaction degree,compliance of medication treatment and quality of life score before and after nursing were compared in patients between the two groups.
Results
After nursing,the total satisfaction degree of the high quality group was 100%,which was higher than of the control group (90%),and the compliance rate of medication treatment in the high-quality group after nursing was 100%,which was higher than that of the control group (92%),and the compliance rate of medication treatment in the two groups after nursing were higher than those before nursing,and the differences were statistically significant(P＜0.05).After nursing,the scores of quality of life in the high quality group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.01).
Conclusion
The high-quality nursing intervention applied in patients with chronic obstructive pneumonia can significantly improve patients′satisfaction degree with nursing,improve the compliance of medication treatment after nursing,and improve the quality of life of patients after nursing,and the effect is ideal.
2019 Vol. 26 (5): 235-237 [
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95
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Application effect of nursing communication skills in transfusion room at pediatric outpatient
LIU Ling-hong
Objective
To investigate the application effect of nursing communication skills in transfusion room at pediatric outpatient.
Methods
All of 92 children with intravenous infusion in transfusion room at pediatric outpatient from June 2016 to September 2017 were selected.46 children with routine nursing intervention from June 2016 to January 2017 were taken as the control group,and 46 children with nursing communication skills based on routine nursing from February to September 2017 were taken as the observation group.The transfusion cooperation of children,mental state score and nursing satisfaction degree of family members were compared between the two groups.
Results
The total transfusion cooperation rate of children in the observation group (93.48%)was higher than that in the control group,and the difference was statistically significant(P＜0.05).SAS and SDS scores of family members in the observation group ([42.35±3.97]points,[41.66±4.08]points)were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total satisfaction degree of nursing in family members of the observation group(91.30%)was higher than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Nursing communication skills in transfusion room at pediatric outpatient can effectively enhance transfusion cooperation of children,and it is helpful to reduce negative emotions of family members,increase nursing satisfaction degree of family members to promote the construction of good nurse-patient relationship.
2019 Vol. 26 (5): 238-240 [
Abstract
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74
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241
Influence of cognitive behavioral nursing intervention on renal function and quality of life in patients with chronic renal failure given hemodialysis
ZHAO Shu-qiu
Objective
To explore the influence of cognitive behavioral nursing intervention on renal function and quality of life in patients with chronic renal failure given hemodialysis.
Methods
All of 80 patients with chronic renal failure given hemodialysis admitted to our hospital from May 2017 to May 2018 were selected as study subjects and they were divided into the control group(40 cases)and observation group(40 cases)according to the nursing method.Routine nursing intervention was used in the control group and cognitive behavior nursing intervention was used in the observation group.Renal function indicators and quality of life score were compared in patients between the two groups.
Results
After nursing,the levels of senem creatinine(SCr)and blood urine nitrogen(BUN)in the two groups were lower than those before nursing,and the levels of SCr and BUN in the observation group after nursing were lower than those in the control group,and the differences were statistically significant(P＜0.05).The scores of quality of life in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Cognitive behavioral nursing intervention applied in patients with chronic renal failure given hemodialysis can significantly improve their quality of life and improve their renal function indicators.
2019 Vol. 26 (5): 241-243 [
Abstract
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98
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244
Influence of acupoint massage combined with rehabilitation nursing on motor function and quality of life in patients with stroke paralysis
ZHANG Feng
Objective
To investigate the influence of acupoint massage combined with rehabilitation nursing on motor function and quality of life in patients with stroke paralysis.
Methods
ll of 80 patients with stroke paralysis admitted to our hospital from September 2016 to May 2018 were selected and they were randomly divided into the two group,each group had 40 cases.The control group received the routine rehabilitation training,while the observation group received the acupoint massage combined with rehabilitation nursing.Then the muscle tension and plantar flexion angle,gross exercise function score and quality of life score after intervention were compared between the two groups.
Results
The muscle tension of the two groups after intervention was lower than that before intervention,and the plantar flexion angle was smaller than that before intervention (P＜0.05),and the muscle tension of the observation group after intervention was lower than that of the control group,and the plantar flexion angle was smaller than that of the control group(P＜0.05).The gross motor function score of the two groups after intervention was higher than that before intervention,and the quality of life score was lower than that before intervention(P＜0.05).The gross motor function score of the observation group after intervention was higher than that of the control group,and the quality of life score was lower than that of the control group (P＜0.05).
Conclusion
Acupoint massage combined with rehabilitation nursing applied in patients with stroke paralysis can can better improve their limb motor ability,reduce their muscle tension and improve their overall quality of life.
2019 Vol. 26 (5): 244-246 [
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96
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247
Application effect of systematic health education in patients with schizophrenia complicated with diabetes mellitus
DING Xi-lian
Objective
To explore the application effect of systematic health education in patients with schizophrenia complicated with diabetes mellitus.
Methods
All of 52 patients with schizophrenia complicated with diabetes mellitus treated in our hospital from January 2016 to December 2017 were selected and they were randomly divided into the observation group and control group,and there were 26 cases in each group.The control group was given the routine health education.The observation group was given systematic health education conducted by nurses on the basis of routine health education methods.The compliance of medication,diet and exercise,the effect of blood glucose and blood pressure control,and satisfaction degree of nursing were observed and compared between the two groups.
Results
After intervention,the compliance rates of medication,diet,exercise,the achievement rate of blood sugar and blood pressure in the observation group were significantly higher than those in the control group,and the total satisfaction degree of nursing in the observation group was 96.15%,which was significantly higher than that in the control group(84.62%),and the differences were statistically significant(P＜0.05).
Conclusion
Systematic health education applied can improve the compliance of patients with schizophrenia complicated with diabetes mellitus,effectively control blood glucose and blood pressure level,improve patients′satisfaction degree,and it is worthy of clinical promotion.
2019 Vol. 26 (5): 247-249 [
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95
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250
Application effect of outpatient nursing intervention in pediatric lingual frenulum plasty
WU Qiao-chun;HUANG Shao-ying;DENG Li-ling;CAO Jing-yu
Objective
To explore the application effect of outpatient nursing intervention in pediatric lingual frenulum plasty.
Methods
From June 2016 to August 2017,92 children with ankyloglossia treated in our hospital were selected as study objects.According to the difference of nursing methods,they were divided into the control group (46 cases)and observation group (46 cases).The control group was given with the routine nursing intervention.The observation group strengthened the outpatient nursing intervention on the basis of the control group.The operation time,nursing effect and satisfaction degree of family members of children were compared between the two groups.
Results
The operative time in the observation group([6.00±1.46]min)was shorter than that in the control group([8.69±2.48]min),and the difference was statistically significant(P＜0.05).The cooperation degree(95.65%),wound healing rate(97.83%)and healing rate(100.00%)of the observation group were higher than those of the control group(78.26%,84.78%,80.43%),and the incidence of related symptoms(2.17%)was lower than that of the control group (19.56%),and the difference were statistically significant(P＜0.05).The satisfaction degree of the family members of the observation group to the nursing staffs′active service(100.00%),attitude enthusiasm(95.65%),health education(100.00%),psychological support(93.48%),caring for the children(97.83%)and overall service(97.83%)was higher than those of the control group(82.61%,80.43%,78.26%,69.57%,76.09%,80.43%),and the differences were statistically significant(P＜0.05).
Conclusion
Outpatient nursing intervention applied in pediatric lingual frenulum plasty is helpful to the improvement of the curative effect and nursing effect,and the effect is very satisfactory.
2019 Vol. 26 (5): 250-252 [
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104
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