慢性阻塞性肺疾病急性发作期的中枢呼吸驱动

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Abstract Objective To investigate the changes of central respiratory drive during acute exacerbation in patients with chronic obstructive pulmonary disease (COPD)without respiratory failure.Methods A total of 88 patients with COPD treated in our hospital from April 2015 to May 2016 were selected as the subjects.None of the patients had respiratory failure.The patients′oral blocking pressure was measured on admission day and after remission,and data analysis was then performed.Results Both in awake and asleep states,the oral obstruction pressure (P0.1)of patients with COPD during acute exacerbation was significantly higher than that in remission,and the difference was statistically significant(P＜0.05).The P0.1 in sleep state was lower than that in awake state,and the difference was statistically significant(P＜0.05).Conclusion Central respiratory drive of patients with COPD is at a high output in the acute episode,meaning that central respiratory drive is increased in patients with COPD during acute exacerbations,and is weakened in sleep state.

Key words： Chronic obstructive pulmonary disease Acute attack Respiratory drive；Oral blocking pressure

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	Articles by authors
	LIU Dong-guo
	ZHANG Li-wei
	ZHANG Zhen
	XIA Kun-gang
	TAO Ying-xiu
	WEI Jing-liang
	LI De-zheng

Cite this article:

LIU Dong-guo,ZHANG Li-wei,ZHANG Zhen, et al. 慢性阻塞性肺疾病；急性发作；呼吸驱动；口腔阻断压[J]. 中国当代医药, 2019, 26(5): 41-43.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I5/41

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