免疫球蛋白治疗轮状病毒性肠炎患儿炎性反应的临床效果

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Abstract Objective To explore the effect of Immunoglobulin in the treatment of inflammatory reaction in children with rotavirus enteritis.Methods Sixty four children with rotavirus enteritis admitted to our hospital from October 1,2016 to February 1,2018 were selected as research subjects.They were divided into control group (32 cases)and observation group (32 cases)according to the random sampling method.The control group received conventional symptomatic treatment and placebo,and the observation group received intravenous Immunoglobulin on the basis of the conventional symptomatic treatment.The fresh feces of the two groups were collected as specimens.The total effective rate of treatment,the levels of tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6)and secretory immunoglobulin A(SIgA)before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.75%,which was higher than that in the control group(75.00%),and the difference was statistically significant(P＜0.05).There were no significant differences in the levels of TNF-α and IL-6 between the two groups before treatment(P＞0.05).The levels of TNF-α and IL-6 after treatment in the two groups were significantly lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of TNF-α and IL-6 after treatment in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the level of SIgA between the two groups before treatment(P＞0.05).The levels of SIgA on the 1st,2nd,3rd,4th,and 5thdays after treatment in the two groups were higher than those before treatment,and the differences were statistically significant(P＜0.05).The levels of SIgA on the 1st,2nd,3rd,4th,and 5thdays after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The effect of Immunoglobulin is significant in the treatment of the inflammatory reaction in children with rotavirus enteritis.

Key words： Immunoglobulin Rotavirus pediatric enteritis Inflammatory response Application effect

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	HUANG Lie-peng

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HUANG Lie-peng. Clinical effect of Immunoglobulin in the treatment of inflammatory reaction in children with rotavirus enteritis[J]. 中国当代医药, 2019, 26(5): 108-110.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I5/108

[3]	陆作洁，农少云，黄翠波.轮状病毒肠炎患儿异型淋巴细胞和免疫球蛋白的检测及分析[J].临床和实验医学杂志，2014，13（3）：228-230.
[4]	陆作洁，农少云，黄翠波.轮状病毒肠炎患儿异型淋巴细胞和免疫球蛋白水平的变化分析[J].检验医学与临床，2014，11（1）：62-63.
[5]	郝雯颖，夏萍，王红.轮状病毒肠炎患儿血清免疫球蛋白、补体及抗炎／促炎因子的动态变化及意义[J].中国现代医生，2017，55（24）：71-74.
[6]	李绍明，屈华平，李倩.免疫球蛋白对轮状病毒性肠炎患儿炎性反应的影响及疗效分析[J].中外医学研究，2018，16（1）：6-7.
[1]	许海涛.轮状病毒肠炎患儿异型淋巴细胞计数及免疫球蛋白检测的意义及临床价值分析[J].吉林医学，2015，36（9）：1851-1852.
[2]	中华医学会儿科学分会消化学组.中国儿童急性感染性腹泻病临床实践指南[J].中华儿科杂志，2016，54（7）：483-488.
[7]	张晓俐，严海燕.布拉酵母菌散联合双歧杆菌四联活菌片治疗小儿轮状病毒性胃肠炎效果分析[J].社区医学杂志，2016，14（15）：55-57.
[8]	李俊利，朱华，刘炎洁.婴幼儿轮状病毒性肠炎合并心肌损害的临床分析[J].中国继续医学教育，2016，8（35）：81-82.
[9]	杨兰萍.轮状病毒性肠炎患儿肝功能、心肌酶谱指标的变化及临床意义[J].海南医学院学报，2016，22（23）：2883-2885.
[10]	张建丽，周优丽.炎琥宁注射液对轮状病毒性肠炎患儿心肌酶谱及炎性因子的影响[J].中国中医药科技，2017，24（2）：135-137.
[11]	王丽，黄娟，冷红春.秋泻灵联合双歧杆菌三联活菌制剂对小儿轮状病毒性肠炎免疫系统及微炎症状态的影响[J].中国妇幼保健，2017，32（17）：4140-4143.
[12]	李磊，王军，张静.降钙素原、C反应蛋白和心肌酶CKMB检测在轮状病毒性肠炎患儿中的诊断价值[J].宁夏医学杂志，2017，39（8）：705-707.
[13]	童本利.热毒宁注射液治疗小儿轮状病毒性肠炎的疗效分析[J].中国继续医学教育，2016，8（33）：224-225.
[14]	郑平，孙先军，郭宇红.抗轮状病毒免疫球蛋白治疗婴幼儿轮状病毒肠炎疗效观察[J].中国妇幼保健，2007，22（29）：4108-4109.
[15]	冯伊利，金蓓娇，李成军.免疫球蛋白对小儿轮状病毒性肠炎的疗效研究[J].中国妇幼健康研究，2016，27（11）：1373-1375.