叶酸代谢基因多态性及血浆同型半胱氨酸水平与新生儿早产、出生体重的关系

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Abstract Objective To discuss the relationship between folic acid metabolism gene polymorphism,plasma homocysteine (Hcy)level and premature birth and birth weight of newborns.Methods A total of 344 pregnant women having prenatal examinations and finally giving birth to their children in our hospital from January 2016 to December 2017 were selected as study objects and their oral mucosa specimens at the early pregnancy stage were collected.According to the results of genetic testing,the genetic risk of folic acid metabolic disorder was graded,and they were divided into the middle/high risk group(182 cases)and non/low risk group(162 cases).Blood samples were taken to detect the level of Hcy.The correlation between Hcy level and neonatal preterm birth and birth weight was analyzed,and the incidence of premature birth was compared between the two groups.Results Hcy level was positively correlated with neonatal birth weight(r=0.143,P=0.008);MTRR A66G genotype was positively correlated with neonatal preterm birth(r=0.126,P=0.019);total genotype risk was positively correlated with neonatal preterm birth (r=0.120,P=0.026).The preterm birth rate in the middle/high risk group was higher than that in the non/low risk group (P=0.027).The Hcy level of pregnant women with macrosomia was higher than that of pregnant women with normal birth weight and low birth weight(P＜0.05).There was no significant difference in body redistribution among different risk level of folic acid metabolic disorder(P=0.483).Conclusion The utilization of folic acid was correlated with preterm birth.The incidence of preterm birth is significantly increased in the middle/high risk group of folic acid metabolic disorder.Neonatal birth weight is affected by maternal Hcy level,and maternal Hcy level is positively correlated with neonatal birth weight.

Key words： Folic acid metabolism gene polymorphism Premature birth Homocysteine Birth weight

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	WANG Rui
	WU Shu-zhen
	CHEN Juan
	LI Yi-ying

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WANG Rui,WU Shu-zhen,CHEN Juan, et al. The relationship between folic acid metabolism gene polymorphism,plasma homocysteine level and premature birth and birth weight of newborns[J]. 中国当代医药, 2019, 26(5): 4-7.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I5/4

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