大剂量羟考酮缓释片治疗晚期癌性疼痛的效果

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Abstract Objective To explore the efficacy of high-dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain.Methods A total of 48 patients with advanced cancer pain admitted to our hospital from April 2017 to April 2018 were selected as the study subjects.They were divided into the control group(n=24)and the observation group(n=24)according to different treatment methods.The control group was treated with Morphine Sulfate Sustained-Release Tablets,while the observation group was treated with high-dose(120-280 mg)Oxycodone Hydrochloride Sustained-Release Tablets.The pain digital scoring method (NRS)scores,analgesic effects and adverse reactions were compared between the two groups before treatment and 15 days after treatment.Results There was no statistically significant difference in the NRS score between the two groups before treatment(P＞0.05).The NRS scores of the two groups after 15 d treatment were significantly lower than those before treatment(P＜0.05).Compared with the control group,the NRS score of the observation group decreased more significantly after treatment(P＜0.05).The total effective rate of analgesia in the observation group was significantly higher than that in the control group after 15 days of treatment,with significant difference (P＜0.05).The total incidence of adverse drug reactions in the observation group was significantly lower than that in the control group,with significant difference (P＜0.05).Conclusion High-dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain patients have reliable efficacy,with obvious analgesic effect,less adverse reactions,good safety,it is worthy of clinical reference and application.

Key words： Advanced cancer pain Morphine Sulfate Sustained-Release Tablets High-dose Oxycodone Sustained-release Tablets Effect Safety

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	ZHOU Yu
	LI Ling
	LI Jie

Cite this article:

ZHOU Yu,LI Ling,LI Jie. Effect of high dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain[J]. 中国当代医药, 2019, 26(5): 77-79.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I5/77

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