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2018 Vol. 25, No. 20
Published: 2018-07-18
4
Effect of Raphanussativus extract on serum inflammatory factor and gastrointestinal motility in rats with early postoperative inflammatory small bowel obstruction
XIAO Zhi-qiang;ZHONG Wei-quan;LIU Qi-long
Objective
To investigate the effects of Raphanussativus extract on serum inflammatory factor and gastrointestinal motility in rats with early postoperative inflammatory small bowel obstruction (EPISBO).
Methods
Twenty-four adult SD rats were randomly divided into three groups according to random number list method,with eight rats in each group.The EPISBO models were generated by wiping the wall of rat′s small intestine and subsequently were given gastriclavage(twice/day)with saline group(NS group),Raphanussativus extract group(Rex group)and moxabili group(Mos group)1 ml/100 g for one week.The serum high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor(TNF-α)were measured by enzyme-linked immunosorbent assay(ELISA),and gastrointestinal motility was studyed.
Results
The expressions of hs-CRP,IL-6,IL-8,TNF-α in Rex group were significantly lower than that in NS group and Mos group,and the differences were statistically significant(P<0.05).The lleal mucosal injury score in Rex group was significantly lower than that in NS group and Mos group,and the differences were statistically significant(P<0.05).The 24 h small intestinal transit ratio in Rex group was significantly higher than that in NS group and Mos group,and the differences were statistically significant(P<0.05).
Conclusion
Rex can reduce serum inflammatory factor level and promote small bowel peristalsis in rats with inflammatory intestinal obstruction.
2018 Vol. 25 (20): 4-7 [
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154
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8
Influence of Chinese herbal medicine Millettia speciosa champ on the synovial cells inflammation of mouse model induced by urate
HUANG Hui;CHEN Hong; HUANG Gui-qiong;YUAN Wei-wei
Objective
To investigate the influence of Chinese herbal medicine Millettia speciosa champ on the synovial cells inflammation of mouse model induced by urate.
Methods
A total of 60 male Wistar mice of grade SPF were randomly divided into the normal control group,the model group,and the study group(low doses group of 4.55 g/kg,middle does group of 9.10 g/kg,and high doses group of 13.65 g/kg),10 cases in each group.Except for the normal control group,the drug was continuously given to 7 d,while the normal control group and the model group did not take any medicine,and given the same amount of normal saline daily to the stomach,the other four groups were injected urate into the right ankle joint to create an acute gouty arthritis model.The levels of serum nitric oxide(NO),interleukin-1β(IL-1β),tumor necrosis factor(TNF-α),prostaglandin E
2
(PGE
2
),and serum uric acid(UA)were measured and compared between before model establishment and after injection of urate 48 h.After successful examination,the model group was sacrificed and the joint capsule and synovial tissue were selected.HE staining was used to observe the pathological changes of the synovial tissue of the right ankle joint in mice.Each dose group was decocted with low,medium and high doses of Millettia speciosa champ,each group was treated with gavage for 1 times at 9 am,for 7 consecutive days.In the treatment of 3 and 7 d,the levels of serum inflammatory factors and serum UA levels in the low,medium and high doses groups of Millettia speciosa champ were measured again,and after 7 d treatment,the synovial tissues of two groups were stained with HE to observe the pathological changes of synovial tissue in the right ankle.
Results
The level of serum NO in four groups after injection of urate 48 h was lower than that before modeling,while the serum levels of IL-1β,TNF-α,PGE
2
and serum UA were higher than those before the modeling,with significant difference (P＜0.05).HE staining showed that there was congestion and swelling in the blood vessels of synovial tissue in the medium and high doses groups of Millettia speciosa champ,and the infiltration of inflammatory cells was obvious.The serum NO levels in the low,medium and high dose groups of Millettia speciosa champ in the treatment of 3 and 7 d were significantly higher than those in the model group,and the level of serum inflammatory factors and serum UA in the low,medium and high dose groups of Millettia speciosa champ in the treatment of 3 and 7 d were lower than that in the model group,with significant difference (P＜0.05).The serum NO levels in the low,medium and high dose groups of Millettia speciosa champ in the treatment of 3 and 7 d were significantly higher than those before treatment,and the level of serum inflammatory factors and serum UA in the low,medium and high dose groups of Millettia speciosa champ in the treatment of 3 and 7 d were lower than that before treatment,with significant difference (P＜0.05).After treatment for 7 d,HE staining showed that the inflammatory infiltration of the synovial tissue in the low,middle and high doses group of Millettia speciosa champ was improved and the disease was relieved,but there was no obvious improvement in the synovial tissue inflammation in the model group.
Conclusion
Chinese herbal medicine Millettia speciosa champ can help alleviate the inflammation of the mouse model synoviocytes induced by urate,which is worthy of popularizing.
2018 Vol. 25 (20): 8-11 [
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165
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12
Expression dynamics and association of cTfh cells and miR-146a in the immune response to hepatitis B vaccination
YU Zu-wei;LI Yu-lian;CHEN Li-hua;YIN Ming-juan;HUANG Ling-feng;ZHANG Yan
Objective
To detect the dynamic expression levels of miR-146a and circulating T follicular helper(cTfh)cell during immune response of hepatitis B vaccination,and then analyze the association between miR-146a,cTfh cell and the immune response of hepatitis B vaccination.
Methods
In July 2017,a group of healthy adults who had completed the standard procedure for the hepatitis B vaccination in Community Health Service Center of Dalang Country were recruited to receive one dose of hepatitis B vaccination,and peripheral blood samples were collected from 12 volunteers at different time points after vaccination,ELISA method was used to measure the concentration of Hepatitis B surface antibody(HBsAb)in serum;Flow cytometry was used to detect the proportion of Tfh cells,B cells,plasma cells,and memory B cells in peripheral blood mononuclear cells(PBMCs).Real-time fluorescence quantitative PCR was used to detect the relative expression of miR-146a.
Results
cTfh cell reached the highest level(P=0.001)on the 7
th
day after vaccination,and the HBsAb reached the highest level on the 14
th
day after vaccination,and the difference was statistically significant(P<0.001).There was a negative correlation between the Tfh cells and B cells(r=-0.426,P=0.03),and a positive correlation between the plasma cells and HBsAb (r=0.330,P=0.04).There was no significant correlation between the expression level of miR-146a,cTfh cell and HBsAb (P＞0.05).
Conclusion
Tfh cells might play a role in the immune response to hepatitis B vaccination,but not demonstrate the association between miR-146a and the immune response of hepatitis B vaccination.
2018 Vol. 25 (20): 12-15 [
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157
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16
Explore the biological efficacy of Pilose Antler using text mining technology and bioinformatics method
GUO Bin;ZHANG Hao-min;YANG Bo;HE Pei-feng; LU Xue-chun
Objective
To explore the biological efficacy of Pilose Antler using the method of literature data mining combined with bioinformatics analysis method from the view of gene expression profiles.
Methods
Firstly,text mining technology was used to explore literatures on gene expression regulation of Pilose Antler from CNKI,Wanfang and CQVIP Data.Gene expression data were extracted,duplicates were removed,and then the gene names were normalized.Secondly,Cytoscape was used to make the protein-protein interaction network.Then the association analysis was used to get the indications and contraindications of disease treatment by the"disease-gene-compound"analysis platform developed by our team.Next,DAVID online analysis tools was used to enrich and analyze the KEGG pathway functions and screen out the corresponding biological pathways and targets.At last,the accuracy of this method was tested and verified by referring to the ancient books and literature on the pharmacological effects of Pilose Antler.
Results
In this paper,30 antler-related regulatory genes were extracted,of which 21 were up-regulated and 9 were down-regulated;the protein-protein interaction network of antler-related genes was produced;the association analysis found more than a dozen species indications and contraindications of Pilose Antler;KEGG pathway enrichment analysis found the pathways and targets of Pilose Antler in three functions of anti-tumor,anti infection and enhancing immunity.The feasibility of this method was verified by consulting pharmacological literature.
Conclusion
Text mining combined with bioinformatics analysis is a new method to explore pharmacological mechanisms and efficiencies of traditional Chinese medicine.
2018 Vol. 25 (20): 16-20 [
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173
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21
Application value of serum prostate-specific antigen in the diagnosis of prostate cancer and related influence factors of prostate cancer
CHEN Jie-sheng;HUANG Yin-qun
Objective
To explore the application value of serum prostate-specific antigen(PSA)in the diagnosis of prostate cancer and the related influence factors of prostate cancer.
Methods
From January 2012 to January 2017,135 cases of prostate diseases in our hospital were selected as the research object.All patients received pathological biopsy and were divided into the prostate cancer group(n=15)and the prostatic hyperplasia group(n=120)according to the results of the disease examination.The serum PSA level in patients with venous blood was measured and the optimal truncation value of the diagnosis of prostate cancer was determined by receiver operating characteristic (ROC)curve.The clinical data of patients with prostate cancer group and prostate hyperplasia group were collected.The independent risk factors of prostate cancer were determined by Logistic multivariate regression analysis.
Results
The serum PSA level in the prostate cancer group was(19.52±10.72)ng/ml,which was higher than that in the prostate hyperplasia group ([7.24±4.45]ng/ml),the difference was statistically significant(P＜0.05).The optimal truncation value of serum PSA for predicting prostate cancer was 16.584 ng/ml,and the sensitivity and specificity were 80.0%and 79.2%,respectively.The proportion of the spermarcheal age less than 14 years,the frequency of sexual life was more than 4 times per week,with a family history of prostate cancer,the positive rate of serum PSA in the prostate cancer group accounted for 86.67%,60.00%,60.00%,66.67%,compared with benign prostatic hyperplasia were higher,the differences were statistically significant(P＜0.05).Logistic multivariate regression analysis revealed positive correlation between sexual frequency,family history of prostate cancer,serum PSA and prostate cancer(P＜0.05).
Conclusion
The continuous detection of serum PSA is of high predictive value for prostate cancer,independent risk factors for prostate cancer include frequency of sex,family history of prostate cancer,and serum PSA levels.
2018 Vol. 25 (20): 21-24 [
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153
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25
Advances in the study of application of combination of retroperitoneal laparoscopy and traditional Chinese medicine in treatment of upper ureteral calculi
LI Jian-min;ZHAO Hong; RAO Pin-lang;SHEN Si-yao;XIONG Jun-hui;CHEN Xiao-hong
The current surgical procedures for the treatment of ureteral stones comprise extracorporeal shock wave lithotripsy(ESWL),ureteroscopic lithotripsy(URSL),retroperitoneoscopic ureterolithotomy(RPUL),and minimally invasive percutaneous nephrolithotomy (mPCNL),of which RPUL is especially suitable for the treatment of upper ureteral calculi complicated with pyonephrosis.RPUL not only can remove the stones completely,reduce the intraoperative haemorrhage,and almost has no effect on the changes in the internal pressure of renal pelvis,with a low probability of complications including leakage of urine,ureteral stenosis and septic shock,but also can be used for intraoperative treatment of complications such as ureteral polyps.At the same time,treatment of urolithiasis with the traditional Chinese medicine has a very obvious advantage.The antipyretic drugs can relieve the fever.The drenched drugs can promote the excretion of toxins through urine,thus greatly reducing the risks of postoperative infection and fever.The combination of Chinese and Western medicine can promote the recovery of the patients,which has more and more extensive clinical application.This paper reviews the progress in research of application of combination of retroperitoneoscopy and traditional Chinese medicine in the treatment of upper ureteral calculi.
2018 Vol. 25 (20): 25-27 [
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171
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28
Application of probiotics in the treatment of Helicobacter pylori infection in children
ZHU Xiang-li
The most dangerous of Hp infection is the children.Antibiotic therapy is the main method of Hp infection.However,the long-term use of antibiotics caused by adverse reactions and the emergence of bacterial resistance,resulting in the eradication of Hp infection rate decreased year by year.In recent years,it has been suggested that probiotics had significant advantages in improving the eradication rate of Hp infection and reducing adverse reactions.In this paper,the application of probiotics in the treatment of Hp infection in children was reviewed.
2018 Vol. 25 (20): 28-30 [
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132
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31
Comparison of clinical efficacy between laparoscopic inguinal hernia repair and open filling tension-free repair
ZHANG Ri-xiong;WU Zu-guang;LI En;ZHANG Zhuo-xin;ZENG Hai-jing;LI Zhi-wang;WU Wei-sheng
Objective
To analyze and compare the clinical effects of laparoscopic inguinal hernia repair and open-filling tension-free herniorrhaphy.
Methods
From January 2015 to January 2017,78 patients with inguinal hernia were selected.According to random number table method,they were divided into the study group (n=40)and the control group (n=38).The two groups were treated by laparoscopic herniorrhaphy (TEP)and open hernia ring filling tensionfree repair respectively.The perioperative indexes,postoperative complications and recurrence in one year were analyzed and compared between the two groups.
Results
The time of getting out of bed,the time of hospitalization and the duration of postoperative pain in the study group were shorter than those in the control group(P<0.05),and the amount of intraoperative bleeding was lesser than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the operation time between the two groups(P＞0.05),but the cost of hospitalization of the study group were higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of postoperative complications such as incision infection,urinary retention,scrotal emphysema,serum swelling and neurosensory abnormality were not significantly different between the two groups (P＞0.05).There was no significant difference in postoperative recurrence between the two groups(P＞0.05).
Conclusion
TEP and open hernia ring filling tension-free repair are safe and effective methods for inguinal hernia.Laparoscopic inguinal hernioplasty is more minimally invasive and faster recovery,but there is no obvious advantage in postoperative complications,and the cost of treatment is high.It is recommended to select the appropriate operation method according to the specific conditions of the patients.
2018 Vol. 25 (20): 31-33 [
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162
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34
Clinical effect analysis of laparoscopic minimally invasive surgery combined with endoscopy in the treatment of gastrointestinal tumors
LI Xing-hua;LI Jun;LIU Jie;XIE Ying-qing;LYU Pei-biao
Objective
To explore the clinical effect of laparoscopic minimally invasive surgery combined with endoscopic therapy in the treatment of gastrointestinal tumors and to provide theoretical basis for improving the treatment level of gastrointestinal tumors.
Methods
From October 2016 to October 2017,80 patients with gastrointestinal neoplasms were selected as study subjects.They were divided into experimental group and control group by random number table method,40 cases in each group.The patients in the control group were treated with traditional open surgery and the patients in the experimental group were treated with laparoscopic minimally invasive surgery combined with endoscopy.The operative time,intraoperative bleeding volume,postoperative catheter retention time,postoperative exhaust time and postoperative complications(infection,diarrhea and vomiting)were compared between the two groups.
Results
The operation time of the the experimental group was(100.34±0.34)min,which was significantly shorter than that of the control group of(135.23±20.23)min （P<0.05）.In the experimental group,the intraoperative blood loss was(46.32±6.21)ml,which was losser than that of the control group of(100.34±10.34)ml(P<0.05).The postoperative catheter retention time in the experimental group was(2.42±1.36)d,which was shorter than that in the controi group of(3.22±1.34)d(P<0.05);The postoperative exhaust time in the experimental group was(2.56±0.98)d,which was shorter than that in the control group of(4.02±1.34)d(P<0.05).The incidence of total complication in experimental group was 10.0%,which was lower than that in control group 27.5%,the difference was statistically significant(P<0.05).
Conclusion
Laparoscopic minimally invasive surgery combined with endoscopic treatment of gastrointestinal tumors can shorten the operative time,reduce the amount of intraoperative bleeding,shorten the retention time of the catheter,shorten the postoperative exhaust time,and reduce postoperative complications.
2018 Vol. 25 (20): 34-36 [
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141
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37
Clinical analysis of 20 cases of hypopituitarism
SUN Xiao-li
Objective
To explore the main clinical features and curative effect of hypopituitarism,and provide guidance for the clinical diagnosis and treatment of hypopituitarism.
Methods
A total of 20 hypopituitarism patients from May 2014 to June 2017 were selected as observation objects.The clinical data of 20 patients were analyzed retrospectively to study the main clinical characteristics and curative effect of hypopituitarism.
Results
The average age of the male group was lower than that in the female group,and the difference was statistically significant(P＜0.05）.The cause analysis showed that the proportion of schihan syndrome was higher than other reasons,and the difference was statistically significant(P＜0.05）.The clinical manifestations of patients for example.Anemia,fatigue,dyslipidemia,hyponatremia,nausea and vomiting,short stature,and external genital dysplasia were more common.The hypofunction of the endocrine axis was mainly due to hypothyroidism,hypothyroidism,hypogonadism，and hypogonadism.After treatment,20 patients with hypopituitarism all recovered and discharged from the hospital.
Conclusion
The etiology and clinical manifestations of hypopituitarism are more,and it should be combined with the actual condition of the patients to formulate a suitable treatment plan in clinical.
2018 Vol. 25 (20): 37-39 [
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141
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40
Analysis of common causes of emergency syncope
GAO Peng;Qiao Xiao-xue;Xue Xin-yu;WU Xian
Objective
To analyze the common causes of syncope in emergency department and the treatment strategies.
Methods
Patients with syncope who were treated in the emergency department of our hospital from November 2016 to November 2017 were selected as observation subjects in this study.A total of 136 patients were sampled in one year.According to different age groups,all patients were divided into three groups,including 40 patients in the 15-34 years old group,42 patients in the 35-54 years old group,and 54 patients in the 55-75 years old group.A retrospective analysis was performed on the clinical data of all patients with emergency syncope,and the presence and underlying causes of underlying diseases were analyzed and summarized.
Results
The basic diseases of the three groups of emergency patients with syncope found that there was no significant difference among all age groups(P＞0.05);among common causes of the three groups of patients,cardiac syncope was found.There were 46 patients in total,accounting for 33.82%;56 patients with neuronal syncope,accounting for 41.18%;12 patients with orthostatic hypotension syncope,accounting for 8.82%;16 patients with brain-derived syncope accounting for 11.76%;other causes of syncope in 6 patients,accounting for 4.41%.The 15-34 years old group was mainly young and middle-aged people with syncope and the proportion was significantly higher than other people (P＜0.05）;Cardiac syncope in the 55-74 years old group was maialy elderly people cardiac syncope was significantly higher than that of other people (P＜0.05）.
Conclusion
The most common cause of acute syncope in young and middle-aged patients is nerve-mediated.However,for cardiogenic syncope,it is good for the elderly population.The staff of the emergency department can analyze the causes of syncope according to the changes in the patient′s clinical symptoms and physical signs,and formulate corresponding treatment strategies for them.
2018 Vol. 25 (20): 40-42 [
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43
Application effect of antiviral therapy with Lamivudine combined with Adefovir Dipivoxil in patients with hepatitis B cirrhosis
LI Guo-bin;HUANG Rong-wang;WEI Di;CHEN Ming
Objective
To analyze the clinical effect of antiviral therapy in hepatitis B cirrhosis.
Methods
According to the randomized method,60 patients with hepatitis B cirrhosis were diagnosed and treated in our hospital from February 2015 to March 2017.They were equally divided into control group and observation group,30 cases in each group.In the control group,routine symptomatic treatment and Lamivudine were used,while in the observation group,Lamivudine Plus combined with Adefovir Dipivoxil as antiviral therapy was adopted.The effect of the two groups were compared.
Results
The total effectiveness rate of hepatitis B liver cirrhosis in the observation group was significantly higher than that of the control group (P<0.05）.The Child-Pugh score and prothrombin activity in the observation group were significantly higher than those in the control group （P<0.05）.HBV-DNA in the observation group was significantly lower than that in the control group （P<0.05）.There was no significant difference between the two groups before the intervention of PCⅢ,IVC,LN,or HA （P＞0.05）.The changes of differences in liver fibrosis indexes such as PCⅢ,IVC,LN,and HA in the observation group were significantly lower than those in the control group after intervention （P<0.05）.Besides,the changes of these indexes above-mentioned in the two groups after intervention were significantly lower than those before intervention,which were displayed statistical significance （P<0.05）.
Conclusion
Lamivudine combined with Adefovir Dipivoxil as anti-virus is effective in the treatment of hepatitis B cirrhosis.The clinical effect is reliable.It can remarkably alleviate the hepatic fibrosis,increase the activity of prothrombin,and reduce HBV-DNA.
2018 Vol. 25 (20): 43-45 [
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146
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46
Clinical observe of Kushen Decoction combined with narrow-band ultraviolet in chronic generalized eczema
FU Xue-mei;JIA Qing-lan;YIN Jian-rong;LIU Huai-qi
Objective
To observe the efficacy of Kushen Decoction combined with Narrow-band Ultraviolet B(NB-UVB)in chronic generalized eczema and effect in helper T lymphocyte (Th),immunity.
Methods
A total of 72 patients with chronic generalized eczema from August 2015 to August 2017 were selected and randomized into control group and therapy group with random number table method,36 cases in each group,and all patients taken irradiateing NB-UVB and smearing with Chushi zhiyang ointment,and patients in therapy group taken Kushen Decoction bath in additional,and course of treatment was 28 days,and levels of Th1,Th2 and Th1/Th2 were observed and levels of Interleu kin-2 (IL-2)and interferon (IFN-γ)were contrasted before and after treatment,curative effect and adverse reaction were observed.
Results
Levels of h1,Th2,Th1/Th2,IL-2 and IFN-γ were no statistical different in two groups before treatment(P＞0.05),and levels of Th1,Th2 were decreasing and Th1/Th2 was increasing after treatment,and differences were significative in statistics(P<0.05),and levels of Th1,Th2 were lower and Th1/Th2 was higher in therapy group than in control group after treatment,the differences were significative in statistics (P<0.05).Levels of IL-2 and IFN-γ were decreasing after treatment in two group after treatment than before treatment(P<0.05),levels of IL-2 and IFN-γ were lower in therapy group than in control group after treatment,the differences were significative in statistics (P<0.05),clinical efficiency was 97.2%in therapy group and was 75.00%in control group,and clinical efficiency was higher in therapy group than in control group (P<0.05).And incidence rate of adverse reaction that was urning,tingling,dizziness,nausea was no difference between control group and therapy group(P＞0.05).
Conclusion
Kushen Decoction combined with Narrow-band Ultraviolet could adjust Th cell immune in chronic generalized eczema,and improve curative effect,and had well clinical effect.
2018 Vol. 25 (20): 46-49 [
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50
Effects comparison of Nifedipine and Amlodipine Besylate in the treatment of patients with obesity complicated with hypertension
LONG Fei-long;YE Jun;HUANG Ai-hua
Objective
To compare the effects of Nifedipine and Amlodipine Besylate in the treatment of patients with obesity and hypertension.
Methods
A total of 60 cases of patients with obesity and hypertension who were treated in our hospital from January 2017 to January 2018 were selected for the study and were divided into study group(n=30)and control group (n=30)according to random number table method.Study group was given Amlodipine Besylate,and control group was given Nifedipine,and the two groups were treated for 4 week.The blood lipids(triglyceride[TG],total cholesterol[TC],high density lipoprotein cholesterol[HDL-C],low density lipoprotein cholesterol[LDL-C]),blood glucose(fasting plasma glucose[FPG],fasting insulin[FIns])and blood pressure(systolic blood pressure[SBP],diastolic blood pressure [DBP])were compared between the two groups before treatment and after 4 week of treatment,and the treatment effects and the occurrence of adverse reactions were recorded.
Results
There was no significant difference in each index between the two groups before treatment(P＞0.05).After 4 week of treatment,the incidence rate of adverse reactions in study group was lower than that in control group(6.67%vs.23.33%)(χ
2
=3.890,P=0.049),while the total effective rate in study group was higher than that in control group(96.67%vs.80.00%)(χ
2
=4.750,P=0.029).After 4 week of treatment,the levels of DBP and TC,TG,LDL-C,HDL-C were lower than those before treatment(P<0.05).The levels of DBP and TC,TG,LDL-C，HDL-C in study group after treatment were lower than those in control group (P<0.05).The blood glucose FPG,FIns value and blood pressure SBP after 4 week of treatment in the two groups were not significantly different from those before treatment(P＞0.05).
Conclusion
Nifedipine and Amlodipine Besylate both can effectively lower blood pressure,and the latter one has better antihypertensive efficacy and has more obvious effects on blood lipids,blood pressure and blood glucose,and it has lower incidence rate of adverse reactions than the former one.
2018 Vol. 25 (20): 50-53 [
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Clinical observation of CT-guided percutaneous
125
I radioactive particles for the treatment of superficial metastatic squamous cell carcinoma
125I radioactive particles for the treatment of superficial metastatic squamous cell carcinoma[J]. 中国当代医药, 2018,25(20): 54-56')" href="#">
YANG Jia-wen;CUI Zhe;XIE Chun-fang;ZHU Xing-pei;ZHONG Zu-jun;LU Xing-juan
Objective
To investigate the specific effect and clinical value of CT-guided percutaneous
125
I radioactive particle implantation in patients with superficial metastatic squamous cell carcinoma.
Methods
Sixty patients with superficial metastatic squamous cell carcinoma from January 2016 to June 2017 in our hospital were selected and divided into control group and observation group with 30 cases in each group by random number table method.The control group received chemotherapy.The observation group underwent CT-guided percutaneous
125
I radioactive particle implantation treatment.The total effective rate and the incidence of skin toxicity were compared between the two groups.
Results
The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The incidence of skin toxicity in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).
Conclusion
Compared with chemotherapy,CT-guided percutaneous
125
I radioactive particle implantation has a lower incidence of skin toxic and side effects and obtains a better overall effect,which is worthy of promotion in hospitals.
2018 Vol. 25 (20): 54-56 [
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141
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Short-term effect of celecoxib combined with CapeOX regimen in the treatment of advanced gastric cancer
YANG Hai-jing;TIAN Dan;WU Jian
Objective
To investigate the short-term effect of celecoxib combined with CapeOX regimen in the treatment of advanced gastric cancer.
Methods
A total of 84 patients with advanced gastric cancer admitted to our hospital from May 2015 to November 2017 were selected and divided into control group and observation group according to the order of admission,with 42 cases in each group.The control group was treated with capeox regimen,while the observation group was treated with oral celecoxib on the basis of the control group.The incidence of adverse reactions and the total effective rate were compared between the two groups.
Result
The total effective rate in the observation group was significantly higher than that in the control group,the difference was statistically significant(P>0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group,the difference was statistically significant(P>0.05).
Conclusion
For patients with advanced gastric cancer,the combined method of Celecoxib and CapeOX can greatly reduce the adverse event rate,increase the effective rate,improve the life quality and extend the survival time.
2018 Vol. 25 (20): 57-59 [
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Clinical effect of medical ozone water in the treatment of radioactive oral ulcer of nasopharyngeal carcinoma
HU Jian-feng;HONG Shun-yuan;ZHENG Guang-liang1
Objective
To investigate the therapeutic effect of ozonated water on radiation-induced oral ulcer.
Methods
Forty nasopharyngeal carcinoma patients who underwent concurrent chemoradiotherapy or radiotherapy from July 2015 to June 2017 in our hospital were selected as the research objects.They were divided into control group and experimental group with 20 cases in each group by random number table method.Patients in the experimental group were rinsed with self-made Vitamin B
12
solution(0.9%sodium chloride 500 ml+Vitamin B
12
,500 μg)for 10 min,4 times/d,and ozonated water(concentration:15 μg/L)for 10 min,2 times/d respectively.Patients in the control group were gargled with Vitamin B
12
solution for 10 min and 8 times/d each time.After 7 days of gargle treatment,the curative effect was evaluated.
Results
After 7 days of treatment,the total effective rate in the experimental group was significantly higher than that in the control group(P<0.05).Two patients in the experimental group showed slight nausea and no vomiting.No nausea or vomiting occurred in the control group.The patients of two groups had not any adverse reactions such as allergy or poisoning,and the difference was not statistically significant(P>0.05).
Conclusion
Ozone water is cost-effective,safe and effective in the treatment of radioactive oral ulcers,which can be used as a new treatment method.
2018 Vol. 25 (20): 60-62 [
Abstract
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199
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63
Feasibility of sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer
LI Min;HUANG Zhan;LI Xiao-yong;LEI Rui-wen;YANG Chuan-sheng;ZHANG Kai;CHEN Zhuo-rong;LU Hai
Objective
To investigate the predictive value of sentinel lymph node biopsy （SLNB）for axillary lymph node staging after neoadjuvant chemotherapy （NAC）.
Methods
Thirty-one new breast cancer patients admitted to our hospital from January 2017 to March 2018 were selected as the research objects,and were divided into control group（16 cases）and experimental group（15 cases） by random number table method.After NAC,SLNB was performed in the experimental group,followed by modified radical mastectomy plus axillary lymph node dissection.The control group underwent NAC after SLNB,followed by modified radical mastectomy plus axillary lymph node dissection.The detection rate,false negative rate,accuracy,negative sensitivity and sentinel lymph node metastasis rate of the two groups were compared through the pathological conditions of the detected lymph nodes.
Results
There was no statistically significant difference in false negative rate,accuracy and negative sensitivity between the two types of patients(P>0.05).The detection rate of sentinel lymph node metastasis in the experimental group was lower than that in the control group,and the difference was statistically significant (P ＜0.05）.
Conclusion
Sentinel lymph node biopsy after neoadjuvant chemotherapy can also predict axillary lymph node metastasis,but further study is needed for long-term prognosis.
2018 Vol. 25 (20): 63-65 [
Abstract
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159
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66
Effect of cancer-induced fatigue on the quality of life of the patients with gynecological cancer during chemotherapy
CHEN Jun;GENG Hong-ling;QIN Xiao-hui
Objective
To investigate the effect of cancer-induced fatigue on the quality of life of the patients with gynecological cancer during chemotherapy.
Methods
A total of 118 patients with gynecological malignancy who were hospitalized from June 2014 to June 2017 were selected for a questionnaire survey,so as to analyze the correlation between cancer-related fatigue and quality of life.
Results
Physical fatigue scored was the highest,followed by emotional fatigue and cognitive fatigue.The overall health status of patients during chemotherapy was poor.There was a significant negative correlation between cancer-related fatigue and overall health (P<0.05).There was a significant negative correlation between cancer-related fatigue and various functional areas of quality of life (P<0.05).Cancer-related fatigue was significantly and positively correlated with various symptom areas of quality of life(P<0.05).Cancer-related fatigue was significantly and positively correlated with sleep disorders and economic conditions (P<0.05).
Conclusion
There is a correlation between cancer-induced fatigue and quality of life during chemotherapy in the patients with gynecological cancer.The more severe the cancer-induced fatigue,the worse the quality of life.
2018 Vol. 25 (20): 66-68 [
Abstract
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147
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69
Analysis of clinical characteristics and pulmonary CT characteristics in children with obliterans bronchiolitis
TANG Hui-ying;SONG Ping;FU Dan
Objective
To investigate the clinical characteristics and pulmonary CT characteristics in children with obliterans bronchiolitis.
Methods
A total of 35 children with obliterans bronchiolitis treated in our hospital from January 2015 to December 2017 were selected.The clinical characteristics and pulmonary CT characteristics were analyzed.
Results
Of the 35 cases,20.00%(7/35)was caused by premature lung injury,and 80.00%(28/35)was caused by Bacterial,virus infection.The types included 2 cases of Pseudomonas aeruginosa,4 cases of measles virus,4 cases of mycoplasma infection,1 cases of EB virus and 6 cases of cytomegalo virus.In another 11 cases,the cause of infection was unknown.31 cases (88.57%)of bronchial wall thickening,11 cases (31.43%)of atelectasis or consolidation,24 cases (68.57%)of patchy or high point density,8 cases (22.86%)of bronchial mucus plug (25.71%),9 cases of bronchiectasis,35 cases(100.00%)of mosaic perfusion syndrome.
Conclusion
It is of great significance to understand the clinical characteristics of children with obliterative bronchiolitis and actively carry out CT examination,which can improve the accuracy of diagnosis and improve the prognosis.In the process of diagnosis and treatment,the CT examination of the lung should be given to the children.
2018 Vol. 25 (20): 69-71转78 [
Abstract
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128
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72
Efficacy of Estradiol Valerate combined with Medroxyprogesterone in preventing intrauterine adhesions after moderate to severe intrauterine adhesion
HUANG Yong-shen;MENG Feng-ming
Objective
To investigate the effect of Estradiol Valerate Tablets combined with Medroxyprogesterone in the prevention of intrauterine adhesion after moderate and severe intrauterine adhesion debonding.
Methods
A retrospective analysis of 64 patients with severe intrauterine adhesions in our hospital from January 2015 to December 2017 was divided into operation group (n=31)and combined group (n=33)according to different treatment method.Both groups underwent laparoscopic intrauterine adhesioslysis and placement of IUD after operation.The combination group was treated with Estradiol Valerate Tablets and progesterone.The duration of postoperative bleeding was compared between the two groups,bleeding and abdominal pain,cervical adhesions.
Results
The recurrence rate of intrauterine adhesions in the combined group was 19.35%,which was significantly lower than that in the operation group(41.94%)(P＜0.05）.The postoperative bleeding time,duration of abdominal pain,menstruation recovery time was shorter than that in the operation group,the bleeding volume was lesser than that in the operation group and endometrial thickness in the combined group were better than those in the operative group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05）.
Conclusion
Estradiol Valerate and progesterone acetate can effectively prevent the occurrence of uterine adhesions and increase the incidence of uterine adhesions after moderate-to-severe intrauterine adhesions release without increasing the incidence of adverse reactions.
2018 Vol. 25 (20): 72-74转90 [
Abstract
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171
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75
Effect observation of Neuromuscular stimulation therapy instrument in vulval dystrophy
GUO Ling;HUANG Hua-yi
Objective
To investigate the effect of Neuromuscular stimulation therapy instrument in the treatment patients with vulval dystrophy.
Methods
A total of 88 patients with vulvar dystrophy in our hospital from December 2016 to June 2017 were enrolled as research objects,which were confirmed by pathology.All the patients were treated with Neuromuscular stimulation therapy instrument,5 times for a course,the patients with Mild disease had been treated for 1-2 course and the patients with moderate-severe disease had been treated for 2-3 course.Outpatient follow-up were promoted after 1,3 and 6 months treatment,the improvement of the genital itching,genital skin elasticity,genital skin color,extent of the reduction of leukoplakia were observed,the overall clinical efficacy and the efficacy of different pathological types were compared.
Results
The cure rate of Neuromuscular stimulation therapy instrument was 40.91%in vulvar dystrophy,the significant effective rate was 40.91%,the improvement rate was 17.05%and the total effective rate was 98.86%.The effect of different pathological types was different(χ
2
=14.945,P＜0.05）.The genital itching disappeared ratio after treatment was 81.82%,the transient itching ratio was 9.09%.There was a statistically significant difference in the improvement of pruritus among different pathological types(χ
2
=15.562,P＜0.05）.The good vulva skin elasticity ratio was 81.82%after treatment,there was a statistically significant difference in the improvement of pruritus among different pathological types(χ
2
=16.587,P＜0.05）.The rate of good genital skin color after treatment was 62.5%,and there was significant difference in the improvement of pruritus among different pathological types(χ
2
=42.218,P＜0.01）.The completely disappear rate of vulvar white spot was 40.91%,the rate of 60%deflation of vulvar white spot was 30.68%,the rate of 30%deflation of vulvar white spot was 27.27%,there were significant differences in the reduction of vulvar white spot among different pathological types (χ
2
=13.483,P＜0.05）.
Conclusion
Neuromuscular stimulation treatment instrument has exact clinical curative effect in the treatment of vulval dystrophy,and can improve vulva skin elasticity,vulvar skin color,vulvar white spot.
2018 Vol. 25 (20): 75-78 [
Abstract
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149
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79
Application effect of low-frequency pulse electrical stimulation combined with biofeedback therapy in the treatment of female stress urinary incontinence
YANG Yan-hua HUANG Hui-ping
Objective
To investigate the clinical effects of low-frequency pulse electrical stimulation combined with biofeedback therapy in female stress urinary incontinence.
Methods
A total of 94 patients with female stress urinary incontinence were collected from July 2016 to November 2017 in this study.They were divided into the control group and the study group according tcrandom number table method,47 cases in each group.Patients in the control group were given pelvic floor exercises.The study group was given low-frequency pulse electrical stimulation combined with biofeedback therapy based on the control group.The pelvic floor muscle strength after treatment in the two groups of patients was compared.At the same time,the international urinary incontinence questionnaire (ICIQ-SF)was used to compare the symptoms and effects of urinary incontinence after treatment between the two groups of patients.In addition,the bladder neck rotation angle and the bladder back angle after treatment were recorded and compared between the two groups.
Results
After treatment,the improvement effect of pelvic floor muscle strength in the study group was significantly better than that in the control group,and the difference was statistically significant(P＜0.05）;the scores of the ICIQ-SF scale in the study group were significantly lower than those in the control group,with statistically significant differences （P＜0.05）;the bladder neck rotation angle and bladder back angle in the study group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05）.
Conclusion
The application of low-frequency pulse electrical stimulation combined with biofeedback therapy in female stress urinary incontinence can achieve good clinical results.This kind of therapy can improve the patient′s clinical symptoms while enhancing the pelvic floor muscle strength,which is beneficial to the patient′s recovery.
2018 Vol. 25 (20): 79-81 [
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142
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82
Diagnostic value of C-reactive protein combined with PCT in pediatric infectious diseases
PENG Wei-bo
Objective
To investigate the diagnostic value of C-reactive protein(CRP)and procalcitonin(PCT)in pediatric infectious diseases.
Methods
From September 2014 to December 2016,200 cases of infectious diseases admitted to our hospital were selected,including 100 cases of bacterial infection(bacterial infection group),100 cases of virus infection(virus infection group)and 100 cases Health staff(health group).Serum levels of CRP and PCT were measured by immunoturbidimetry.The positive rates of CRP and PCT in each group were analyzed and compared,and the diagnostic value of CRP and PCT in pediatric infectious diseases was evaluated by drawing the working curve of the subjects.
Results
The CRP and PCT levels in bacterial infection group were higher than those in virus infection group and healthy group(P＜0.05）.CRP and PCT levels in virus infection group and healthy group were similar,with no difference(P＞0.05）.The positive rate of CRP in bacterial infection group was higher than that in healthy group,and the positive rate of PCT was higher than that in virus infection group and healthy group (P＜0.05）.The CRP positive rate and PCT positive rate of healthy subjects were similar,with no significant difference （P＞0.05）.ROC curve analysis showed that the sensitivity of bacterial infection was 100.00%and the specificity was 94.66%when the critical value of PCT was 0.83 μg/L.The sensitivity and specificity of diagnosing virus infection were 98.93%and 93.14%.The sensitivity of diagnosis of bacterial infection was 94.97%and specificity was 87.43%when the critical value of CRP was 46.4 μg/L.The sensitivity and specificity of diagnosis of viral infection was 84.98%and 79.62%respectively;The diagnosis of bacterial infection by CRP ROC AUC was 0.842(95%CI=0.754-0.929),ROC AUC was 0.800(95%CI=0.701-0.899)for diagnosis of viral infection,and ROC AUC for PCT diagnosis of bacterial infection was 0.668 (95%CI=0.548-0.889),ROC AUC for diagnosing viral infection was 0.729 (95%CI=0.614-0.845).
Conclusion
CRP and PCT can be used for clinical diagnosis of routine indicators of pediatric bacterial infections,but the value of the application of pediatric viral infections is not high,and it needs to be combined with other indicators for diagnosis.
2018 Vol. 25 (20): 82-84 [
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131
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85
Effect comparison of laparoscopy and laparotomy in the treatment of endometriosis with infertility
YE Yin
Objective
To explore the effect of laparoscopy and laparotomy in the patients with endometriosis with infertility.
Methods
A total of 58 endometriosis with infertility patients from June 2014 to June 2016 in our hospital with surgical treatment for endometriosis were selected as research objects,and were divided into control group (29 cases)and observation group(29 cases)according to random number table method.The patients in the control group were operated on laparotomy,and the patients in the observation group were operated on laparoscopy.The operation time,the amount of bleeding in the operation,the time of postoperative exhaust,the time of the ambulation,the time of hospitalization and the effective rate of treatment were observed in the two groups.The patients were followed up for 1 years,and the pregnancy was recorded.
Results
The operative time,exhaust time,ambulation time and hospitalization time in the observation group were significantly shorter than those in the control group.The intraoperative blood loss in the observation group was significantly lesser than that in the control group.The differences between the two groups were statistically significant(P＜0.01）.The effective rate of the observation group after laparoscopy was significantly higher than that of the control group,and the difference was statistically significant(P＜0.01）.The 1 year pregnancy rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.01）.
Conclusion
Laparoscopic surgery for endometriosis with infertile has the advantages of less bleeding,rapid recovery,significant clinical effect,high pregnancy rate,safe and effective at the same time.
2018 Vol. 25 (20): 85-87 [
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129
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88
Application value of hysteroscopy in the treatment of cervical pregnancy in cesarean section
HE Wen-shu
Objective
To investigate the value of hysteroscopy in the treatment of cervical pregnancy in cesarean section.
Methods
From June 2016 to June 2017,100 cases of cesarean cervical pregnancy admitted in our hospital were selected as the research object.According to the single and double numbers of the treatment date,they were divided into observation group and control group,50 cases in each group.Patients in the observation group were treated with hysteroscopy.The control group was treated with the most simple and simple method.HCG levels,intraoperative blood loss,uterine recovery time and the incidence of postoperative complications were compared between the two groups.
Results
The levels of HCG ([15 333.53±143.32]U/L),blood loss in operation ([296.92±24.21]ml),time of uterine recovery (14.64±2.42)d,and the total incidence of complication during hospitalization in hysteroscopic surgery group(8%)was significantly lower than that of the control group([27 536.37±116.46]U/L),blood loss([382.42±21.37]ml),uterine recovery time[25.49±2.73]d)and the incidence of complications(36.00%).All the data in the table were statistically significant after analysis(P＜0.05）.
Conclusion
For patients undergoing cesarean section with cervical pregnancy treated in our hospital,hysteroscopic surgical treatment is applied to the clinical treatment process,which can effectively reduce the amount of bleeding during operation,shorten the recovery time of the uterus and reduce HCG level in patients,greatly reducing the patients′risk of complications during hospitalization,it is worth in the clinical promotion.
2018 Vol. 25 (20): 88-90 [
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116
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91
Effect of placental abruption on coagulation function indexes and platelet morphology parameters in pregnant women
ZHENG Xue-feng;LIU Ting;XU Qing-xia
Objective
To explore the effect of placental abruption on coagulation function indexes and platelet morphology parameters in pregnant women.
Methods
Altogether 50 pregnant women with placental abruption who were treated in our hospital from April 2015 to September 2017 were randomly selected as group A;while,50 patients with pregnancy induced hypertension were selected as group B;100 cases of healthy pregnant women who were treated in our hospital at the same period of time were selected as control group.The clinical data of three groups of patients were analyzed retrospectively.The coagulation function indexes and platelet morphological parameters of the three groups were detected and evaluated by using fully automated coagulation analyzer.
Results
①It was revealed from the coagulation function indexes of the two groups of subjects that the prothrombin time(PT)and activated partial thromboplastin time(APTT)indexes of group B＜ control group＜group A,with statistically significant difference among three groups(P＜0.05）;there was no statistically significant difference between the three groups in thrombin time (TT)(P＞0.05）;D-dimer(D-D)of group B＞group A＞control group(P＜0.05）;the fibrinogen(FIB)of group B＞control group＞group A(P＜0.05）;②According to the platelets morphology parameters of the three groups,the platelet distribution width(PDW),mean platelet volume(MPV)and platelet-large cell ratio(P-LCR)of group B＞group A＞control group(P＜0.05）;and the platelet counts(PLT)of group B＜group A＜control group(P＜0.05）.
Conclusion
Placental abruption and pregnancy induced hypertension have a great influence on the blood coagulation function indexes and the platelet morphology parameters.It indicates from another point of view that the dynamic observation of these two kinds of indexes can help to find abnormal conditions in early stage and give appropriate treatment in time.
2018 Vol. 25 (20): 91-93 [
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136
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94
Analysis of related risk factors for postpartum hemorrhage in women of advanced maternal age
XIAN Yan-li;DENG Yu
Objective
To analyze the risk factors of postpartum hemorrhage in women of advanced maternal age by using retrospective study methods and to discuss the intervention measures to prevent and reduce postpartum hemorrhage in order to provide reference for the prevention and treatment of postpartum hemorrhage in the women of advanced maternal age.
Methods
Altogether 47 women of advanced maternal age who underwent delivery and postpartum hemorrhage in our hospital from January 2016 to October 2017 were selected as the observation group;while,another 47 cases of women of advanced maternal age who underwent delivery without postpartum hemorrhage in our hospital during the same period were selected as the control group.The clinical data of two groups of patients were summarized and analyzed,and the risk factors related to postpartum hemorrhage were determined by using single factor and multiple factor Logistic regression analysis.
Results
There was no statistically significant difference in the general data of age,body mass index and gestational weeks between the two groups (P＞0.05).There was no statistically significant difference in the general data of smoking history,drinking history and family medical history between two groups(P＞0.05).It was shown according to the data that factors,such as multiple pregnancy,gestational hypertension(GH),placenta praevia,placental abruption,placental adhesion/implantation/residue,uterine inertia,macrosomia,laceration of birth canal and coagulation dysfunction,were associated with postpartum hemorrhage(P<0.05);factors such as gestational diabetes and multiple pregnancy were not significantly associated with postpartum hemorrhage(P＞0.05).According to the multiple factor Logistic regression analysis,it indicated that postpartum hemorrhage was the result of multiple factors.The significant risk factors related to postpartum hemorrhage were multiple pregnancy,gestational hypertension,placenta praevia,placental abruption,placental adhesion/implantation/residue,uterine inertia and macrosomia.
Conclusion
Multiple pregnancy,gestational hypertension,placenta praevia,placental abruption,placental adhesion/implantation/residue,uterine inertia and macrosomia are significant risk factors for postpartum hemorrhage.Doctors and pregnant women should pay attention to preoperative diagnosis,prevention and post-operative treatment of high-risk factors so as to reduce the rate of postpartum hemorrhage.
2018 Vol. 25 (20): 94-96转100 [
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118
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Effect of Pituitrin in the treatment of tubal pregnancy by laparoscopy conservative operation
HOU Cui;TANG Xiao-xia;ZHANG Ping;ZENG Yan-hua;YANG Zhi-hong
Objective
To investigate the effect of Pituitrin in the treatment of tubal pregnancy by laparoscopy conservative operation.
Methods
A total of 120 cases of oval tube pregnancy were selected from April 2015 to September 2016 in our hospital,all patients were divided into observation group and control group according to random number tablt method,60 cases in each group.The control group was treated with laparoscopic conservative surgery,and the patients in the observation group were injected with Pituitrin in the fallopian tube mesangial membrane before laparoscopy.The clinical effect of the patients after treatment,volume,hemostasis time,operation time,hospitalization time,postoperative bleeding in patients with postoperative body temperature records,records of patients before and after 1 and 4 days after the operation,after 7 days of blood beta-HCG value change,pregnancy rate were recorded and compared with continuous flow rate of ectopic oviduct tube.
Results
After treatment,the total efficiency of observation group was 98.33%,higher than 86.67%in the control group (P＜0.05）;the postoperative bleeding of the observation group was significantly lesser than the control group,the bleeding time,operation time and hospitalization time were significantly shorter than the control group(P＜0.05）;the observation group postoperative body temperature([37.35±0.65]℃） was significantly lower than that of the control group([37.62±0.48]℃） (P＜0.05）.After 7 days,4 days after operation,the level of β-HCG of the observation groupweresignificantlylowerthanthatofthecontrolgroup(P＜0.05）;thetubalflowrateoftheobservationgroup was 81.67%,higher than the control group of 51.67% (P＜0.05）;the incidence of persistent ectopic pregnancy of the observation group was 0.00%,significantly lower than the control group of 15.00%,the differences were statistically significant(P<0.05).
Conclusion
Pituitrin is effective in laparoscopic conservative surgery for tubal pregnancy,and it can reduce blood beta-HCG value,improve tubal smooth rate and persistent ectopic pregnancy rate,and is worthy of promotion.
2018 Vol. 25 (20): 97-100 [
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116
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101
Clinical effect of Oxytocin combined with Misoprostol in preventing postpartum hemorrhage
LI Shu
Objective T
o investigate the clinical effect of Oxytocin combined with Misoprostol in preventing postpartum hemorrhage.
Methods
A total of 120 cases of term vaginal delivery in our hospital were randomly divided into two groups from October 2016 to October 2017,60 cases in each group.The control group was given intramuscular injection of Oxytocin 10 U and intravenous drip of 10 U after delivery,the obseruation group on the basis of the control group,Misoprostol 400 μg plug anus was administered,compared the two groups with the rate of postpartum hemorrhage,the amount of postpartum hemorrhage,the time of the third stage of labor,the changes of blood pressure and heart rate before and after administration.
Results
The postpartum haemorrhage rate was 1.67%,significantly lower than 15.00%in the control group,significantly less than the control group with 2 h and 24 h,and the differences were statistically significant(P<0.05).The third stage of the observation group was significantly shorter than the control group,and the difference was statistically significant(P<0.05).In the observation group，the systolic blood pressure,diastolic blood pressure and heart rate were significantly decreased compared with the control group,and the differences were statistically significant(P<0.05).There was no significant difference between the two groups in the incidence of nausea,vomiting,cold war,facial flushing,and elevated blood pressure (P＞0.05).
Conclusion
The clinical effect of Oxytocin combined with Misoprostol on the prevention of postpartum hemorrhage is remarkable.It can effectively shorten the third stage of labor,reduce the amount of postpartum hemorrhage,reduce the rate of postpartum hemorrhage,stabilize hemodynamics,and the adverse reaction is slight,which has positive clinical significance.
2018 Vol. 25 (20): 101-103 [
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120
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104
Clinical pathological analysis of endometrial carcinoma combined with uterine fibroids
YANG Ju-ping;ZOU Qin
Objective
To study the clinical pathological characteristics of endometrial carcinoma combined with uterine fibroids.
Methods
From August 2015 to December 2016,60 patients with endometrial carcinoma combined with uterine fibroids treated in our hospital were selected as group A.Another batch of 60 patients with endometrial carcinoma was randomly selected as group B for research analysis.The tumor histological grades,surgical pathological stages,progesterone receptor(PR),estrogen receptor(ER),ascites cytology,pathological type,and lymph node metastasis were compared and analyzed in both groups.
Results
The pathological stage of group B was significantly higher than that of group A (P<0.05).The tumor pathological grading in the group A was significantly lower than that in the group B with the characteristics of shallow muscle infiltration and high tissue differentiation.After surgery,the positivity rates of PR and ER in the group A were 61.7%and 78.3%.In the group B,the rates were 23.3%and 41.7%respectively.There were significant differences between the two groups (P<0.05).No significant difference in lymph node metastasis,ascites cytology,or pathological types was displayed between the two groups(P＞0.05).
Conclusion
Compared with endometrial carcinoma alone，combination of endometrial carcinoma and uterine fibroids has lower histological stage and tumor pathological grading,shallower muscle infiltration,better tissue differentiation,and higher positivity rates of PR and ER.
2018 Vol. 25 (20): 104-106 [
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150
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107
Changes and significance of vitamin D in the treatment of girls with central precocious puberty
CHEN Hua-qin;DENG Xiao-jun;WU Jin-hua2
Objective
To observe the changes and significance of vitamin D concentration in girls with central precocious puberty （CPP）before and after treatment with gonadotropin releasing hormone analogue.
Methods
From January 2014 to September 2017,49 girls with CPP were selected as study group.And another 49 healthy girls were selected as control group.The vitamin D levels in two groups were measured,and the study group was divided into two groups according to the vitamin D level：study group Ⅰnormal Vit D and study group Ⅱ with Vit D deficiency.The changes of vitamin D concentration in two groups before and after treatment with GnRHa analogue were observed and compared.And the clinical significance was analyzed.
Results
The level of vitamin D in the study group was significantly lower than that in the control group,and the vitamin D level in the study groupⅡwas significantly lower than that in the study groupⅠ (P<0.05).After 6 months of treatment,the levels of vitamin D in study groupⅠand groupⅡwere all decreased,and the level of vitamin D in groupⅡ was significantly lower than that in groupⅠ,the differences were statistically significant(P<0.05).The rate of breast development stopped or subsided after GnRHa treatment in the study groupⅠ was significantly higher than that in the study group Ⅱ (P＜0.05）.
Conclusion
Vitamin D level is generally low in children with CPP,and vitamin D level will decrease in the course of treatment with GnRHa analogue,and vitamin D level has a certain influence on the effect of clinical GnRHa in the treatment of breast development regression.Therefore,adequate vitamin D supplementation is very necessary.
2018 Vol. 25 (20): 107-109 [
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130
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110
Effect of red and blue light auxiliarily treating chronic suppurative otitis media(active stage)
CHEN Yu;LAN Fei;MA Guo-mei
Objective
To explore the effect of red and blue light auxiliarily treating chronic suppurative otitis media(active stage).
Methods
A total of 80 patients with chronic otitis media treated in the outpatient service of department of ENT in Shenzhen Hospital of Southern Medical University from February 2016 to October 2017 were randomly selected and divided into the experiment group (40 cases)and control group (40 cases).The control group was treated with Left Ofloxacin Ear Drops,while the experiment group was treated with Left Ofloxacin Ear Drops combined with red and blue light.The course of treatment was 2 weeks,and the therapeutic effect and hearing improvement between the two groups were compared.
Results
The total effective rate of the experiment group was 85.0%,which was higher than that of the control group (67.5%),and there was a statistical difference (P<0.05).The pre and post-treatment changes in air-bone gap and gas conductivity threshold of the experiment group was significant,and the improvement of hearing was better than that of the control group (P<0.05).
Conclusion
Red and blue light is effective in the treatment of chronic suppurative otitis media(active stage).
2018 Vol. 25 (20): 110-112 [
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103
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113
Practical application of psychological guidance combined with hand shaking retained deciduous teeth in 6-10 years old children with retained deciduous teeth in primary hospital
WANG Zhou-xuan;HUANG Xing-hui
Objective
To investigate the application value of psychological guidance combined with hand shaking retained deciduous teeth in 6-10 years old children with retained deciduous teeth in primary hospital.
Methods
Sixty cases of 6-10 years old children given tooth extraction and treated in Department of Stomatology of the Fourth Hospital of Nanchang City from February 2016 to February 2018 were selected as the research objects and they were divided into the reference group and combination group according to the random number table generated by PEMS3.0 software package.The reference group was only given psychological guidance for infiltration anesthesia to extract a tooth,while the combination group was given psychological guidance combined with hand shaking retained deciduous teeth.The related indexes between the two groups were compared.
Results
The coordination degree in the combined group was better than that in the reference group (P<0.05).The score of tension and fear in the two groups were significantly lower than those before intervention,and the score of tension and fear in the combined group were significantly lower than those in the reference group (P<0.05).The success rate of tooth extraction in the combined group was significantly higher than that in the reference group (P<0.05).The total satisfaction degree of the family members in the combined group was significantly higher than that of the reference group (P<0.05).The incidence of adverse events in the combined group was significantly lower than that in the reference group (P<0.05).
Conclusion
Psychological guidance combined with hand shaking retained deciduous teeth applied in the painless extraction of 6-10 years old children in primary hospital as many positive effects,and it has no risk and is worth promoting.
2018 Vol. 25 (20): 113-116 [
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130
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117
Effect of Phenylephrine combined with Ephedrine on heart rate variability in puerpera undergoing cesarean section
ZHU Mei-lin;ZHENG Wen-hui;CHENG Li-li;ZHANG Ting-ting;Dong You-jing
Objective
To investigate the effect of Phenylephrine combined with Ephedrine on heart rate variability(HRV)during cesarean section in puerperae.
Methods
Ninety full-term single-birth puerperae in ASAⅠ-Ⅱ patients undergoing cesarean section in appropriate time from November 2016 to June 2017 in our hospital were enrolled.They were randomly divided into 3 groups according to the random number table method,with 30 cases in each group.Patients with reduced blood pressure after anesthesia(20%reduction from baseline or systolic blood pressure<90 mmHg)were treated for elevating blood pressure.The 0.15 mg/kg Ephedrine was provided in E group.And 1 μg/kg Phenylephrine was used in P group.In E+P group,Ephedrine(0.1 mg/kg)and Phenylephrine(0.5 μg/kg)were combined used.The HRV low frequency(LF),HRV high frequency(HF),and LF/HF were recorded before anesthesia(T
0
),1 min after injection into the subarachnoid space (T
1
),and at the lowest blood pressure using drugs for elevating blood pressure(T
2
),and 3 min(T
3
),5 min(T
4
),and 10 min(T
5
)after medication.By paired t-test,the indexes at T
3
-T
5
were compared with those at T
0
in order to determine whether there was a statistical difference.
Results
The values of LF and LF/HF at T
1
-T
5
time points in the E group were significantly higher than those at T
0
,and HF was significantly lower than T
0
,the differences were statistically significant(P<0.05).In the P group,the values of LF and LF/HF at T
1
-T
3
time points were much lower than those at T
0
and HF were greatly higher than T
0
,which was displayed statistical significance (P<0.05).In the P group,there was no sig-nificant difference in the values of LF,HF and LF/HF at T
4
and T
5
time points in the P group compared with T
0
(P>0.05).No significant difference in the values of LF,HF and LF/HF at T
3
-T
5
time points compared with T
0
in the E+P group (P>0.05).The LF and LF/HF at T
3
and T
4
time points in the E group were greatly higher than those in the E+P group,HF was significantly lower than that in the E+P group,and the differences were statistically significant(P<0.05).The LF at T
5
time points in the E group was greatly higher than that in the E+P group,HF was significantly lower than that in the E+P group,and the differences were statistically significant(P<0.05).The LF and LF/HF at T
3
time points in the P group were greatly higher than that in the E+P group,HF was significantly lower than that in the E+P group,and the differences were statistically significant(P<0.05).
Conclusion
For puerperae undergoing cesarean section,Phenylephrine combined with Ephedrine can maintain autonomic sympathetic/vagal balance and keep LF,HF,and LF/HF in normal conditions,which is beneficial to the HRV stability.
2018 Vol. 25 (20): 117-120转124 [
Abstract
] (
137
)
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121
Effect comparison of Dexmetodetonidine with Sufentanil and Sufentanil alone in postoperative analgesia after gynecologic laparoscopy
MAI Wei-liang;ZHANG Min-sen;CHEN Rong-qiang;HUANG Xiao-hua
Objective
To compare the clinical effect of Dexmetodetonidine with Sufentanil and Sufentanil alone in postoperative analgesia after gynecologic laparoscopy.
Methods
From June 2016 to June 2017,a toatl of 90 patients undergoing general anesthesia for gynaecological laparoscopic surgery in our hospital were selected as subjects.They were randomly divided into observation group and control group according to the random number table method,with 45 cases in each group.The observation group was treated with Sufentanil(1.5 μg/kg)combined with Dexmetodetonidine(1.0 μg/kg),and the control group was given Sufentanil(1.5 μg/kg)alone.The visual analogue scale (VAS)score,comfort scale(BCS)score,calm degree(Ramsay)score,total dose of Sufentanil consumption,and incidence of adverse reactions were compared between two groups.
Results
The VAS scores at 2,6,12 and 24 h after operation of the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05),there were no statistically significant differences in VAS scores between two groups at 48 h after operation (P>0.05).Ramsay scores at 2,6 and 12 h after operation of the observation group were lower than those in the control group,BCS scores at 2,6 and 12 h after operation of the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in BCS scores and Ramsay scores between two groups in 24 and 48 h after operation (P>0.05).There were statistically significant differences in VAS scores,BCS scores,and Ramsay scores at 6,12,24 and 48 h after operation of two groups compared with 2 h after operation (P<0.05).The Sufentanil consumption dose was less than that in the control group at different time points after operation,and rate of adverse reaction in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).
Conclusion
Dexmedetomidine combined with Sufentanil is more effective than Sufentanil alone in postoperative analgesia after gynecologic laparoscopy and has a high degree of safety,which can reduce the dosage of Sufentanil for analgesia and is worthy of clinical application.
2018 Vol. 25 (20): 121-124 [
Abstract
] (
126
)
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125
Clinical effect of Ulinastatin combined with Thymus New Injection in the treatment of sepsis and the effects on C reactive protein and procalcitonin
WU Han-cong;DENG Tao;LI Jun-ling
Objective
To explore the clinical effect of Ulinastatin combined with Thymus New Injection in the treatment of sepsis and the effects on C reactive protein (CRP)and procalcitonin (PCT).
Methods
From July 2015 to July 2016,a total of 70 patients with sepsis were selected as objects.They were randomly divided into experimental group and control group with 35 cases in each group.The control group was treated with Ulinastatin and the experimental group was treated with Ulinastatin combined with Thymus New Injection.The levels of acute physiology and chronic health scoreⅡ(APACHEⅡ),CRP,PCT and adverse reactions were compared.
Results
After treatment,scores of APACHEⅡin both groups were significantly lower than those before treament,and the score of APACHEⅡof the experimental group was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of CRP and PCT in two groups were significantly lower than before treament,and the levels of CRP and PCT of the experimental group were significantly lower than those of the control group,the differences were statistically significant(P<0.05).One case in the experimental group developed adverse reactions during the course of treatment,and two cases in the control group,the adverse reaction condition of patients disappeared after adjustment.There were no adverse reactions that seriously affected the treatment in both groups.
Conclusion
Ulinastatin combined with Thymus New Injection is effective in the treatment of patients with sepsis and can significantly improve the levels of CRP and PCT of patients.
2018 Vol. 25 (20): 125-127 [
Abstract
] (
140
)
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128
Effect of Enalapril combined with Trimetazidine in the treatment of elderly patients with chronic heart failure
YANG Shao-jun
Objective
To explore the effect of Enalapril combined with Trimetazidine in the treatment of elderly patients with chronic heart failure(CHF)and the effect on N-terminal pro-B-type natriuretic peptide(NT-proBNP)and cardiac function.
Methods
A total of 96 elderly patients with CHF treated in our hospital from November 2016 to October 2017 were selected as objects.They were randomly divided into research group and control group according to the random number table method,with 48 cases in each group.In the control group,Trimetazidine was used on the basis of routine treatment,and in the research group,Enalapril was adopted on the basis of the control group.The clinical efficacy,the NT-proBNP and cardiac function indexes before and after treatment between the two groups were compared.
Results
The total therapeutic effective rate of the research group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the level of Left Ventricular Ejection Fractions(LVEF)in the research group was significantly higher than that of the control group,the levels of Left Ventricular End-Diastolic dimension (LVEDD),Left Ventricular End-Systolic Diameter(LVESD)and NT-proBNP were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).
Conclusion
Enalapril combined with Trimetazidine is effective in the treatment of elderly patients with CHF,which can significantly improve the NT-proBNP level and cardiac function of patients,and is worthy of clinical application.
2018 Vol. 25 (20): 128-130 [
Abstract
] (
124
)
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131
Effect of Pemetrexed combined with Shenqi Fuzheng Injection as first line treatment in elderly patients with advanced lung adenocarcinoma
ZHAN Qin-yuan;CAI Yun;CHEN Ying-lan
Objective
To explore the clinical effect of Pemetrexed combined with Shenqi Fuzheng Injection as first line treatment in elderly patients with advanced lung adenocarcinoma.
Methods
A total of 80 cases of elderly patients with advanced lung adenocarcinoma treated in our hospital from February 2016 to October 2017 were selected as subjects.They were randomly divided into the control group and the observation group with 40 cases in each group,according to the random number table method.The control group was treated with Pemetrexed alone,and the observation group was combined with Shenqi Fuzheng Injection on the basis of chemotherapy in the control group.The total effective rate,the tumor control rate,the incidence of adverse reaction,the sleep quality score and life quality score before and after treatment were compared.
Results
There were no statistically significant differences in total effective rate and tumor control rate between two groups(P>0.05).The incidence of adverse reactions in the observation group(2.50%)was lower than that of the control group (27.50%),and the difference was statistically significant(P<0.05).Before treatment,the scores of sleep quality and life quality in two groups had no statistically significant differences(P>0.05).After treatment,the score of sleep quality in the observation group was lower than that of the control group,the score of life quality was higher than that of the control group,and the differences between the groups were statistically significant(P<0.05).
Conclusion
Pemetrexed combined with Shenqi Fuzheng Injection has some effect in the treatment of elderly patients with advanced lung adenocarcinoma,while combined treatment can effectively reduce the incidence of adverse reactions and significantly improve the prognosis of patients,which is worthy of clinical application.
2018 Vol. 25 (20): 131-133 [
Abstract
] (
122
)
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134
Application effect of Drospirenone and Ethinylestradiol Tablets combined with Flavored Biochemical Granules after induced abortion
WU Li-yan;LI Xiao-mei; LIU Xia
Objective
To explore the application effect of Drospirenone and Ethinylestradiol Tablets combined with Flavored Biochemical Granules after induced abortion.
Methods
From August 2016 to August 2017,women who underwent induced abortion at the gynecologic outpatient of the affiliated hospital of zhaoqing medical college were selected as the research subjects.All the selected subjects were unintended pregnant,voluntarily terminated,and had no history of childbirth or abortion,whose menstruation was normal,with 6 to 10 gestational weeks.Diagnosed with intrauterine pregnancy by Human Chorionic Gonadotropin(β-HCG)and B ultrasound,a total of 162 pregnant women were selected and randomly divided into treatment group and control group with 81 cases in each group.The treatment group was treated with Drospirenone and Ethinylestradiol tablets combined with flavored biochemical granules and the control group was treated with vitamin E capsules.The oluration of vaginal bceeding and endometrial thickness at 3 weeks and menstrual rehydration time at 6 weeks after surgery in both groups were compared.
Results
After eliminating the discontinuation of study patients,71 cases were effectively included in the treatment group and 74 cases in the control group.Return visit after 3 weeks,the duration of vaginal bleeding in the treatment group was shorter than that of the control group,the endometrial thickness was higher than that of the control group,and the differences were statistically significant(P<0.05).After a 6-week telephone interview,the time of menstrual recovery was shorter than that of the control group,and the difference was statistically significant(P<0.05).
Conclusion
Drospirenone and Ethinylestradiol Tablets combined with Flavored Biochemical Granules are effective after induced abortion,which is worthy of clinical application.
2018 Vol. 25 (20): 134-136 [
Abstract
] (
129
)
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137
Clinical effect of Jieyu Ointment combined with Toremifene treating cyclomastopathy due to qi stagnation,blood stasis and phlegm congealing
WANG Fang;LI Juan;ZHAO Shu-wen;GAN Guo-xing
Objective
To study the clinical effect of Jieyu Ointment combined with Toremifene treating cyclomastopathy due to qi stagnation,blood stasis and phlegm congealing.
Methods
One hundred and twenty patients with cyclomastopathy due to qi stagnation,blood stasis and phlegm congealing admitted into our hospital from November 2016 to July 2017 were selected and they were divided into the two groups according to the random number table method,and there were 60 cases in each group.The study group was treated with Jieyu Ointment combined with Toremifene,while in the control group,only Toremifene was adopted.The clinical effect between the two groups was comapred.
Results
The total effectiveness rate of the study group was 93.33%,which was higher than that of the control group accounting(81.67%)(P<0.05).There was no significant difference in the scores of breast pain,the size of mass,and the texture of mass between the two groups before the treatment(P>0.05).After treatment,the above-mentioned scores in the two groups were obviously lower than those before,and there was a statistical difference of the above-mentioned scores between the two groups(P<0.05).The total incidence of adverse reactions in the study group was 5.00%,which was lower than that of the control group accounting (15.00%)and the recurrence rate of the study group was 3.33%,which lower than that in the control group (13.33%),and the differences were statistically significant(P<0.05).
Conclusion
The clinical effect of Jieyu Ointment combined with Toremifene treating cyclomastopathy due to qi stagnation,blood stasis and phlegm congealing is better,and it can effectively relieve pain,improve the size and texture of the tumor,promote the rapid recovery of the disease,avoid recurrence and have high safety.
2018 Vol. 25 (20): 137-139 [
Abstract
] (
130
)
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24
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140
Curative effect observation of Huoxue Huayu Fangzhai Decoction and Aspirin in prevention of coronary artery stenosis in coronary heart disease after PCI
DU Rong-mei
Objective
To investigate the curative effect of Huoxue Huayu Fangzhai Decoction and Aspirin in prevention of coronary artery stenosis in coronary heart disease after(PCI).
Methods
Altogether 520 patients with coronary heart disease treated with PCI from October 2015 to October 2017 in our hospital were selected as the objects of this research by using random draw pattern and divided into the two groups,and there were 260 cases in each group.Patients in the control group were treated with Aspirin after operation while,patients in the observation group were treated with Huoxue Huayu Fangzhai Decoction on the basis of the control group.The clinical effect between the two groups was compared.
Results
The score of traditional Chinese medicine syndrome of the observation group after treatment 3 and 6 months were higher than those of the control group (P<0.05).After treatment,hs-CRP and SIL-2R level of the observation group were lower than those of the control group,and the CD3
+
level was higher than that of the control group(P<0.05).The incidence of coronary restenosis in the observation group was 0.77%,which was lower than that in the control group (4.62%)(P<0.05).
Conclusion
The effect Huoxue Huayu Fangzhai Decoction and Aspirin in prevention of coronary artery stenosis in coronary heart disease after PCI is significant,and at the same time,it is beneficial to inhibit the inflammatory reaction and improve the clinical symptoms of patients.
2018 Vol. 25 (20): 140-142 [
Abstract
] (
129
)
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18
)
143
The influence of Tongsheng Prescription on neurological function deficits,constipation and hs-CRP for acute cerebral apoplexy with blocking syndrome
TAN Jing;NING Wei-min;CHEN Jing-yi;MIAO Xiao-lu;YANG Kang-qiang
bjective
To investigate the influence of Tongsheng Prescription on neurological function deficits,constipation and hs-CRP for acute cerebral apoplexy with blocking syndrome.
Methods All
of 60 patients with acute cerebral apoplexy with blocking syndrome hospitalized in Department of Encephalopathy of Dongguan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine or ICU from March 2016 to March 2018 were selected and they were randomly divided into the two groups and there were 30 patients in each group.On the basis of basic treatment,the treatment group was treated with Tongsheng Prescription while the control group was treated with Angong Niuhuang Pills.The course of treatment was 7 days.The neurological deficits,clinical symptom score of constipation and the change hs-CRP were observed before and after treatment in both groups.
Results
After treatment 3,7 d,clinical symptoms score of constipation in the two groups were decreased,and clinical symptoms score of constipation in the treatment group after treatment 3,7 d was significantly lower than the control group,and the differences were statistically significant(P<0.05).After treatment 7 d,NIHSS score in the two groups were lower than those before treatment,and NIHSS score in the treatment group after treatment 7 d was lower than that of the control group,and the difference was statistically significant(P<0.05).The serum hs-CRP level of after treatment 7 d in the treatment group was significantly decreased,compared with before treatment in the same group,the difference was statistically significant(P<0.05).
Conclusion
Tongsheng Decoction can improve the neurological function of deficits acute cerebral apoplexy with blocking syndrome,.It is speculated that the mechanism may be related to improving constipation symptoms and reducing inflammatory injury after cerebral apoplexy.
2018 Vol. 25 (20): 143-146 [
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] (
146
)
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147
Effect comparision of Modified Chaihu Shugan Powder and western medicine in the treatment of functional dyspepsia with liver depression and qi stagnation
ZHANG Ni;JIANG Hui-hui;CHEN Ji-wen
Objective T
o compare the clinical effect of Modified Chaihu Shugan Powder and western medicine in the treatment of functional dyspepsia with liver depression and qi stagnation.
Methods
All of 140 patients functional dyspepsia of liver depression and qi stagnation treated in our hospital from February 2016 to May 2017 were selected and they were randomly divided into the observation group and control group,and there were 70 cases in each group.The control group was treated with Pantoprazole Enteric Capsules and Domperidone Tablets,while the observation group was treated with Modified Chaihu Shugan Powder.The clinical effect,the change of TCM syndrome score and the serum motilin and gastrin in patients of the two groups after treatment were evaluated.
Results
The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there was no significant difference in the total score of TCM syndrome between the two groups (P>0.05).After treatment,the total score of TCM syndrome in the two groups was significantly lower than that before treatment,and the total score of TCM syndrome after treatment in the observation group was significantly lower than that of the control group (P<0.05).After treatment,serum motilin level in the two groups were significantly higher than those before treatment,and gastrin level were significantly lower than those before treatment(P<0.05).After treatment,the serum motilin level in the observation group was significantly higher than that in the control group,and the serum gastrin level was significantly lower than that in the control group(P<0.05).
Conclusion
Modified Chaihu Shugan Powder and western medicine in the treatment of functional dyspepsia with liver depression and qi stagnation can significantly improve TCM syndrome,promote the gastric motility and promote gastric emptying,and it is worthy of further clinical popularization.
2018 Vol. 25 (20): 147-149转156 [
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] (
145
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150
Correlation between smoking index and carotid artery intima-media thickness in males aged from 15 to 44 years old in Luohu District of Shenzhen City
HUANG Ke-jun;LIU Ting;HAO Jin-zhong;YOU Min-ling;WEI Dong
Objective
To analyze the correlation between smoking index(SI)and carotid artery intima-media thickness(IMT)in 300 male patients aged from 15 to 44 years old in Luohu District of Shenzhen.
Methods
A total of 300 male smokers aged from 15 to 44 years old in Luohu District of Shenzhen from July 2016 to November 2017 were included in the study group,and 300 non-smoking men of the same age were included in the control group.The health survey and physical examination were made,and the correlation between SI and carotid artery IMT was analyzed.
Results
The levels of bilateral carotid artery IMT,carotid artery stiffness index,PSV/EDV and PI in the study group were higher than those in the control group,and the levels in the left side were higher than those in the right side (P<0.05).The levels of bilateral carotid artery CC and DC in the study group were lower than those in the control group,and the levels in the left side were lower than those in the right side(P<0.05).There was no significant difference in the bilateral carotid artery RI in the study group (P>0.05).There was no significant difference in the bilateral carotid artery IMT,carotid artery elasticity parameters and carotid hemodynamics indexes between bilateral in the control group (P>0.05).There was a significant positive correlation between SI and bilateral carotid artery IMT (P<0.05).
Conclusion
Smoking can cause the thickening of bilateral carotid IMT and the decrease of carotid artery elasticity and blood flow velocity.With the increase of SI,the IMT thickening of bilateral carotid artery is more significant.
2018 Vol. 25 (20): 150-152转166 [
Abstract
] (
151
)
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153
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153
Detection of prevalence of metabolic syndromes among 18-69-year-old residents in Shenzhen Baoan District and analysis of related factors
GUO Yan-fang;PENG Ji;LIU Zheng;LIU Man-yun;ZHAO Ren-cheng;CHEN Qing;ZHOU Hai-bin;LU Zhi-wei;HE Xiang-yang
Objective
To understand the detection results of the prevalence of metabolic syndromes(MS)and related factors of 18-69-year-old residents in Shenzhen Baoan District so as to provide a scientific basis for the formulation of effective prevention and control measures for MS.
Methods
A total of 1276 permanent residents in Baoan District were selectedbythe probability proportionate to size(PPS)sampling method to participate in the questionnaire survey,physical examination and blood biochemical index determination in 2015.The MS status of the different characteristic population was calculated,and the related factors were analyzed by using the unconditional Logistic regression model.
Results
A total of 1196 valid questionnaires were obtained,whose results showed that the detection rate of MS in residents aged 18 to 69 in Baoan District was13.98%,and the low high density lipoprotein-cholesterol (HDL-C) detection rate was the highest among the MS components..The results of Logistic regression model showed that female,older age,higher waist circumference,higher systolic blood pressure(SBP),higher diastolic blood pressure(DBP),higher fasting plasma glucose(FPG),higher triglycerides(TG)were the risk factors for MS.The higher HDL-C was the protective factor for MS.
Conclusion
The detection rate of MS among residents in Shenzhen Baoan District is relatively high.The screening system for high-risk groups should be established and implemented to customize the MS prevention and control measures for women and olderpeople,which can effectively prevent the occurrence of metabolic diseases and cardiovascular and cerebrovascular diseases.
2018 Vol. 25 (20): 153-156 [
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] (
144
)
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157
Social investigation and analysis of euthanasia and organ donation in Zhengzhou
ZHAO Xue-fei;SUN Ning; XU Xue-qin;QU Jun-ge;YANG Xin-yu;WANG Jun-li
Objective
To know the cognition and attitude of Zhengzhou citizens based on euthanasia,and provide reference for the policies about for euthanasia.
Methods
A self-made questionnaire was used to investigate the euthanasia in four districts of Zhengzhou from April to October in 2016.
Results
A total of 700 questionnaires were investigated for euthanasia,and 692 valid questionnaires were collected.50.43%of them approved euthanasia,and 86.6%of them had a certain understanding of euthanasia.On the cognition and attitude of euthanasia,there were significant differences among different occupations,educational backgrounds and age groups(P<0.05),and there was no significant difference between genders(P>0.05).
Conclusion
The citizens in Zhengzhou have high awareness of euthanasia in general and the proportion of euthanasia is relatively high.Most people are cautious about the implementation of euthanasia.
2018 Vol. 25 (20): 157-159 [
Abstract
] (
136
)
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28
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160
Influence factors of the long-stay schizophrenia patients complicated with chronic cardiovascular diseases
OUYANG Shao-wei;XIE Ji-qun;WANG Xiu-qin;CAO Zhi;ZHONG Yuan-hui
Objective
To analyze the morbidity and related influence factors in long-stay schizophrenia patients complicated with chronic cardiovascular diseases.
Methods
A total of 405 long-stay schizophrenia patients from January 2015 to December 2017 treated in four general wards of our hospital were selected as the subjects.The morbidity of chronic cardiovascular diseases was counted.The medication conditions of the anti-psychotics as well as the body weight and blood pressure were observed.
Results
For 405 cases,there were 129 cases complicated with chronic cardiovascular diseases(31.85%),including 58 hypertension cases(44.96%),42 hyperlipidemia cases(32.56%),20 coronary heart disease cases(15.50%)and 9 remaining cases(6.98%).The patients′age,disease course,family history and medication conditions of anti-psychotics for long-stay schizophrenia patients complicated with and without chronic cardiovascular diseases were significantly different(P<0.05).According to the Logistic regression analysis,it was known that the influence factors of chronic cardiovascular diseases included the age,disease course,family history and medication conditions of anti-psychotics(P<0.05).
Conclusion
The morbidity for long-stay schizophrenia patients is significantly higher than that of the common people.The influence factors of old age,long disease course,family history and long-term medication of anti-psychotics can increase the incidence rate of chronic cardiovascular diseases.
2018 Vol. 25 (20): 160-162 [
Abstract
] (
138
)
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25
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163
Implementation of a hierarchical scientific research management system in hospitals——A case study of projects funded by the National Natural Science Foundation of China
CHEN Zhuo;YIN Cheng-hong
From 2014,Beijing Obstetrics and Gynecology Hospital start to implement a hierarchical scientific research management system.In this study,the application and funding data of NSFC projects from 2013 to 2017 were analyzed,and the effects before and after the implementation of the hierarchical scientific research management system were compared.All of the data suggested that the implementation of the hierarchical scientific research management system has been effective in the management of NSFC projects,and has promoted a several-fold increase in the number of NSFC funding applications and awarded grants.This study could provide evidence for our hospital in improving the hierarchical scientific research management system.
2018 Vol. 25 (20): 163-166 [
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197
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167
Application effect of PDCA circulation in the infection management of the static distribution center in our hospital
WU Qun-fang
Objective
To study and analyze the application effect of PDCA circulation in the infection management of the static center in our hospital.
Methods
A total of 31 cases of infection management personnel of static distribution center in our hospital from January to December in 2016 were taken as the experimental group,the PDCA cycle management was performed.A total of 31 cases of infection management staff in the static distribution center from January to December in 2015 were used as the control group,and routine management was performed.The effect of management and control of infection in the two groups was reviewed and analyzed.
Results
The formation rate of air-settlement bacteria in the experimental group was lower than that in the control group,the difference was statistically significant(P＜0.05).The incidence rate of infectious events in the experimental group was 3.67%,which was lower than 23.33%in the experimental group,the difference was statistically significant(P＜0.05).
Conclusion
The PDCA circulation method can effectively reduce the number of airborne bacteria in the infection management of static distribution center of the hospital,reduce the incidence of hospital static drug-infection incidents,improve the cleanliness of the static distribution center,and ensure the safety of hospital-based static drug treatment.It is worth using.
2018 Vol. 25 (20): 167-169 [
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136
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170
Effect of high quality nursing intervention on treating patients with nonalcoholic fatty liver with Yigan Jiangzhi prescription
FU Yan-yu;ZHANG Ben-ju;ZHANG Ying;YANG Ting-ting
Objective
To explore the effect of high quality nursing on treating patients with nona-lcoholic fatty liver with Yigan Jiangzhi prescription.
Methods
A total of 136 patients with nonalcoholic fatty liver treated by Yigan Jiangzhi recipe from March 2016 to September 2017 were selected and randomly divided into control group and intervention group with 68 cases in each group.After 6 months of treatment,the changes of liver B excess,blood fat,liver function,body weight and waist circumference in the two groups were compared.
Results
The B ultrasound score,waist circumference and body weight of the two groups after the intervention were lower than those before the intervention,and the differences were statistically significant(P<0.05).There was no significant difference between the two groups in B-ultrasound score,waist circumference and weight after intervention (P>0.05).After the intervention,the levels of alanine aminotransferase(ALT),triglyceride(TG)and total cholesterol(CHOL)in the two groups were lower than those before the intervention,and the differences were statistically significant(P<0.05).There was no significant difference in ALT,TG and CHOL levels between the two groups after intervention(P>0.05).The total effective rate of the intervention group was significantly higher than that of the control group(P<0.05).
Conclusion
The high quality nursing intervention can significantly improve the efficacy of Yigan Jiangzhi prescription in the treatment of non-alcoholic fatty liver disease.
2018 Vol. 25 (20): 170-173 [
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127
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174
Application effect of nursing intervention in intravascular intervention for patients with cerebrovascular disease
CAI Wan-xing
Objective
To explore the effect of nursing intervention in intravascular intervention for patients with cerebrovascular diseases.
Methods
Sixty patients with cerebrovascular diseases who underwent intravascular interventional therapy in our hospital from August 2012 to August 2017 were selected and divided into control group and experimental group with 30 cases in each group by odd-even grouping method.Patients in the control group received routine nursing,while patients in the experimental group received comprehensive nursing intervention.The incidence of complications and patients′satisfaction with nursing work were compared between the two groups.
Results
The total incidence of postoperative complications in the experimental group was significantly lower than that in the control group(P<0.05).The nursing quality scores of patients in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).
Conclusion
Nursing intervention for patients with cerebrovascular diseases receiving intravascular interventional treatment can reduce the incidence of postoperative complications and improve the satisfaction of patients with nursing work,which is worthy of clinical popularization and application.
2018 Vol. 25 (20): 174-176 [
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130
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177
Application effect of nursing risk management to nursing for first-time blood donors
LIANG Yu-chu
Objective
To explore the application effect of nursing risk management in the nursing of primary blood donors in schools.
Methods
A total of 500 first blood donors from November 2016 to September 2017 were selected as research objects,and divided into control group and observation group according to whether nursing risk management was carried out,with 250 cases in each group.In November 2016,250 blood donors who carried out routine nursing management from November 2016 to January 2017 were as the control group,250 blood donors who implemented nursing risk management from May to September 2017 as the observation group.The satisfaction and syncope rates of the two groups of blood donors were compared.
Results
The incidence of syncope in the observation group was 2.40%（6/250）,which was higher than that in the control group 12.80%（32/250）,the difference was statistically significant（χ
2
=6.543,P<0.05）.The satisfaction degree of patients in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).
Conclusion
Nursing risk management can made blood donors feel comfortable during blood donation,improve the quality of nursing and reduce the incidence of syncope,which thus is of significant value in the process of collecting blood for first-time blood donors.
2018 Vol. 25 (20): 177-179 [
Abstract
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140
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180
Analysis of application value of quality control circle in improving cleanliness of bowel preparation before colonoscopy
WEI Hao-na;HUANG Hui-juan
Objective
To explore the application value of “quality control circle(QCC)” in improving the cleaning rate of bowel preparation before colonoscopy.
Methods
A total of 186 inpatients who underwent colonoscopy in the Department of Gastroenterology in our hospital during the period from August 2016 to January 2018 were selected as the research objects,and divided into the control group and the analysis grop according to the different admissien time of the patients,with 93 cases in the each group.The control group received bowel preparation before routine colonoscopy,and the analysis group performed QCC management,the cleanliness of bowel preparation and self-scoring performance of QCC members were compared between the two groups.
Results
The total rate of intestinal cleansing in the analysis group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).The self-rating of qcc members in the analysis group was significantly higher than that in the control group(P<0.05).
Conclusion T
he quality control circle has good effect in the preparation of bowel before colonoscopy,which helps to increase the cleanliness rate of the intestine and improve the comprehensive quality of nursing staff.It is worthy of clinical application.
2018 Vol. 25 (20): 180-182 [
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145
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183
Effect observation and safety analysis of evidence-based nursing in patients with cervical spondylotic radiculopathy
WU Jue-hui;JIN Xiang-qian;FENG Hai-yan
Objective
To explore the effect of evidence-based nursing for patients with cervical spondylotic radiculopathy and to provide basis for clinical nursing of patients with cervical spondylotic radiculopathy.
Methods
Sixty-six patients with cervical spondylotic radiculopathy admitted to our hospital from December 2016 to December 2017 were selected as research objects,and were divided into control group and experimental group with 33 cases in each group by random number table method.The control group was given routine nursing while the experimental group was given evidence-based nursing.The study compared the two groups of patients′nursing efficiency,satisfaction score,psychological status score and the incidence of adverse reactions.
Results
The total effective rate of nursing in the experimental group was significantly higher than that in the control group(P<0.05).The scores of patients′satisfaction in the experimental group were significantly higher than those in the control group(P<0.05).The psychological status scores of the two groups after the intervention were significantly lower than those before the intervention,and the psychological status scores of the experimental group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).During the intervention,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).
Conclusion
The results of evidence-based nursing for patients with cervical spondylotic radiculopathy are better and safer.It is worth promoting and practicing in all medical institutions.
2018 Vol. 25 (20): 183-185 [
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134
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186
Effect observations on the treatment of the chinese medicine ironing treatment of lumbar disc herniation with cold dampness syndrome
ZHOU Hai-yan;LU Hai-ping;GOU Xiao-jun
Objective
To explore the effect of temperature and time of pressing for the treatment of lumbar disc herniation patients with cold dampness syndrome clinical nursing effect of traditional Chinese Medicine.
Methods
Sixty-four patients with cold and dampness syndrome of lumbar disc herniation admitted to our hospital from January 2015 to December 2016 were selected and treated by traditional Chinese medicine ironing.They were divided into the first group(40-45℃,15 min)15 patients,the second group(40-45℃,30 min)16 patients,the third group(50-55℃,15 min)16 patients and the fourth group (50-55℃,30 min)17 patients by random number table method.the effects of ironing time on the curative effect were observed respectively under the limit of temperature range.The influence of temperature on curative effect under time-limited conditions.
Results
After treatment,VAS scores were lower than those before treatment,and there was no significant difference (P>0.05).After treatment,there was no significant difference in VAS scores among four groups (P>0.05);the total effective rate of the fourth group was higher than that of the other three groups,and the difference was statistically significant(P<0.01).
Conclusion
The temperature of 40-45℃ or 50-55℃and 15 min or 30 min,four kinds of temperature-time combination of the traditional Chinese medicine ironing therapy has no obvious effect on lumbar disc herniation in patients with cold dampness syndrome VAS score,however,the effective rate of ironing of the fourth group(50-55℃and 30 min)was higher than that of the other three groups.
2018 Vol. 25 (20): 186-188 [
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133
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189
Effect of nursing intervention on quality of life,mastery of health knowledge and medication compliance in patients with hepatitis
CHEN Ming
Objective
To investigate the effect of nursing intervention on the quality of life,mastery of health knowledge and drug compliance in patients with hepatitis.
Methods
Forty patients with chronic hepatitis B admitted to our hospital from August 2015 to June 2017 were selected as research objects,and randomly divided into control group and observation group,with 20 cases in each group.Patients in the control group received general intervention,while patients in the observation group received comprehensive nursing intervention,and the quality of life,health knowledge and medication compliance of the two groups were compared.
Results
After intervention,the scores of quality of life in the two groups were higher than those before intervention,and the difference was statistically significant(P<0.05).After intervention,the scores of quality of life in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The excellent and good rate of mastering health knowledge in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The medication compliance of patients in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).
Conclusion
Comprehensive nursing intervention can effectively improve the quality of life in patients with hepatitis,enhance the mastery of health knowledge and medication compliance,which is worthy of clinical recommendation.
2018 Vol. 25 (20): 189-191 [
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120
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192
Clinical nursing countermeasures analysis of radiation therapy for cervical cancer patients
LIU Jia
Objective
To study and analyze the clinical nursing strategies in the treatment of cervical cancer patients by radiation therapy.
Methods
From January 2015 to October 2017,62 cervical cancer patients in our hospital were selected as experimental subjects.All patients were performed with radiation therapy.They were divided into research group and reference group by computer randomization.In the reference group (n=31),regular care was used,while in the research group (n=31),a comprehensive nursing intervention model was adopted.The nursing satisfaction,occurrence of complications,and anxiety and depression scores before and after nursing in the two groups were comapred.
Results
After statistical comparison and analysis,there was no significant difference in anxiety scores or depression scores before nursing between the two groups(P＞0.05).After nursing,the anxiety score and depression score in the research group were both decreased,which were superior to those in the reference group (P<0.05).The total satisfaction of the research group was 96.77%,which was higher than that in the reference group accounting for 77.42%,which was displayed a statistical difference(P<0.05).The tatal incidence of complications in the research group was 9.68%,which was lower than that in the reference group (35.48%)in statistical significance(P<0.05).
Conclusion
For patients with cervical cancer undergoing radiation therapy,active cooperation of comprehensive nursing intervention can significantly improve patient′s acceptance on nursing service and reduce the incidence of complications,which has an excellent nursing value,and is worthy of application and promotion in clinic.
2018 Vol. 25 (20): 192-194 [
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125
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195
Effect of whole quality nursing on mental health and nursing satisfaction of discharged patients after gallstone operation
LI Yi;LIU Ya-ru
Objective
To study the quality of care throughout the discharge of gallstone patients after mental health and satisfaction with nursing.
Methods
A total of 120 patients with gallstones treated in our hospital from December 2016 to June 2017 were randomly divided into control group and observation group,60 cases in each group.The control group was given routine care,and the observation group was given full quality care.After nursing intervention,the patients′mental health and satisfaction after discharge were compared.
Results
The scores of anxiety and depression in the observation group were lower than those in the control group respectively.The total nursing satisfaction of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).
Conclusion
The whole process of high quality nursing is of great significance to discharged patients after gallstone surgery,which can effectively improve patients′anxiety and depression negative psychology,improve nursing satisfaction and promote the harmonious development of nurse-patient relationship,which is worthy of clinical promotion.
2018 Vol. 25 (20): 195-197 [
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126
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