血清前列腺特异性抗原在前列腺癌诊断中的应用价值及前列腺癌的相关影响因素分析

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Abstract Objective To explore the application value of serum prostate-specific antigen(PSA)in the diagnosis of prostate cancer and the related influence factors of prostate cancer.Methods From January 2012 to January 2017,135 cases of prostate diseases in our hospital were selected as the research object.All patients received pathological biopsy and were divided into the prostate cancer group(n=15)and the prostatic hyperplasia group(n=120)according to the results of the disease examination.The serum PSA level in patients with venous blood was measured and the optimal truncation value of the diagnosis of prostate cancer was determined by receiver operating characteristic (ROC)curve.The clinical data of patients with prostate cancer group and prostate hyperplasia group were collected.The independent risk factors of prostate cancer were determined by Logistic multivariate regression analysis.Results The serum PSA level in the prostate cancer group was(19.52±10.72)ng/ml,which was higher than that in the prostate hyperplasia group ([7.24±4.45]ng/ml),the difference was statistically significant(P＜0.05).The optimal truncation value of serum PSA for predicting prostate cancer was 16.584 ng/ml,and the sensitivity and specificity were 80.0%and 79.2%,respectively.The proportion of the spermarcheal age less than 14 years,the frequency of sexual life was more than 4 times per week,with a family history of prostate cancer,the positive rate of serum PSA in the prostate cancer group accounted for 86.67%,60.00%,60.00%,66.67%,compared with benign prostatic hyperplasia were higher,the differences were statistically significant(P＜0.05).Logistic multivariate regression analysis revealed positive correlation between sexual frequency,family history of prostate cancer,serum PSA and prostate cancer(P＜0.05).Conclusion The continuous detection of serum PSA is of high predictive value for prostate cancer,independent risk factors for prostate cancer include frequency of sex,family history of prostate cancer,and serum PSA levels.

Key words： Prostate cancer Prostate-specific antigen Prostatic hyperplasia Clinical staging Risk factors

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	CHEN Jie-sheng
	HUANG Yin-qun

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CHEN Jie-sheng,HUANG Yin-qun. Application value of serum prostate-specific antigen in the diagnosis of prostate cancer and related influence factors of prostate cancer[J]. 中国当代医药, 2018, 25(20): 21-24.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I20/21

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