白萝卜提取物对大鼠术后早期炎性肠梗阻血清炎症因子及胃肠动力的影响

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Abstract Objective To investigate the effects of Raphanussativus extract on serum inflammatory factor and gastrointestinal motility in rats with early postoperative inflammatory small bowel obstruction (EPISBO).Methods Twenty-four adult SD rats were randomly divided into three groups according to random number list method,with eight rats in each group.The EPISBO models were generated by wiping the wall of rat′s small intestine and subsequently were given gastriclavage(twice/day)with saline group(NS group),Raphanussativus extract group(Rex group)and moxabili group(Mos group)1 ml/100 g for one week.The serum high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor(TNF-α)were measured by enzyme-linked immunosorbent assay(ELISA),and gastrointestinal motility was studyed.Results The expressions of hs-CRP,IL-6,IL-8,TNF-α in Rex group were significantly lower than that in NS group and Mos group,and the differences were statistically significant(P<0.05).The lleal mucosal injury score in Rex group was significantly lower than that in NS group and Mos group,and the differences were statistically significant(P<0.05).The 24 h small intestinal transit ratio in Rex group was significantly higher than that in NS group and Mos group,and the differences were statistically significant(P<0.05).Conclusion Rex can reduce serum inflammatory factor level and promote small bowel peristalsis in rats with inflammatory intestinal obstruction.

Key words： Early postoperative inflammatory small bowel obstruction Serum inflammatory factor Gastrointestinal motility Raphanussativus extract

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	XIAO Zhi-qiang
	ZHONG Wei-quan
	LIU Qi-long

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XIAO Zhi-qiang,ZHONG Wei-quan,LIU Qi-long. Effect of Raphanussativus extract on serum inflammatory factor and gastrointestinal motility in rats with early postoperative inflammatory small bowel obstruction[J]. 中国当代医药, 2018, 25(20): 4-7.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I20/4

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