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| Diagnostic value of C-reactive protein combined with PCT in pediatric infectious diseases |
| PENG Wei-bo |
| Department of Pediatrics,Maoming Traditional Chinese Medicine Hospital,Guangdong Province,Maoming 525000,China |
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Abstract Objective To investigate the diagnostic value of C-reactive protein(CRP)and procalcitonin(PCT)in pediatric infectious diseases.Methods From September 2014 to December 2016,200 cases of infectious diseases admitted to our hospital were selected,including 100 cases of bacterial infection(bacterial infection group),100 cases of virus infection(virus infection group)and 100 cases Health staff(health group).Serum levels of CRP and PCT were measured by immunoturbidimetry.The positive rates of CRP and PCT in each group were analyzed and compared,and the diagnostic value of CRP and PCT in pediatric infectious diseases was evaluated by drawing the working curve of the subjects.Results The CRP and PCT levels in bacterial infection group were higher than those in virus infection group and healthy group(P＜0.05）.CRP and PCT levels in virus infection group and healthy group were similar,with no difference(P＞0.05）.The positive rate of CRP in bacterial infection group was higher than that in healthy group,and the positive rate of PCT was higher than that in virus infection group and healthy group (P＜0.05）.The CRP positive rate and PCT positive rate of healthy subjects were similar,with no significant difference （P＞0.05）.ROC curve analysis showed that the sensitivity of bacterial infection was 100.00%and the specificity was 94.66%when the critical value of PCT was 0.83 μg/L.The sensitivity and specificity of diagnosing virus infection were 98.93%and 93.14%.The sensitivity of diagnosis of bacterial infection was 94.97%and specificity was 87.43%when the critical value of CRP was 46.4 μg/L.The sensitivity and specificity of diagnosis of viral infection was 84.98%and 79.62%respectively;The diagnosis of bacterial infection by CRP ROC AUC was 0.842(95%CI=0.754-0.929),ROC AUC was 0.800(95%CI=0.701-0.899)for diagnosis of viral infection,and ROC AUC for PCT diagnosis of bacterial infection was 0.668 (95%CI=0.548-0.889),ROC AUC for diagnosing viral infection was 0.729 (95%CI=0.614-0.845).Conclusion CRP and PCT can be used for clinical diagnosis of routine indicators of pediatric bacterial infections,but the value of the application of pediatric viral infections is not high,and it needs to be combined with other indicators for diagnosis.
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| [1] |
陈炜，赵磊，牛素平，等.不同炎症因子对细菌性血流感染所致脓毒症患者的早期诊断价值[J].中华危重病急救医学，2014，26（3）：165-170.
|
| [2] |
薛慧敏.新生儿感染性疾病检测方法现状[J].中华妇幼临床医学杂志（电子版），2012，8（4）：441-443.
|
| [3] |
李凡，张伟令，黄东生，等.降钙素原、C反应蛋白在儿童恶性实体瘤并感染及肿瘤进展中的诊断价值[J].中华实用儿科临床杂志，2017，32（10）：743-746.
|
| [4] |
张艳平，周鹂婕.C-反应蛋白联合降钙素原对慢性阻塞性肺病急性加重期中细菌感染的诊疗价值[J].中南大学学报（医学版），2014，39（9）：939-943.
|
| [5] |
付晓红，周启明，赵艳，等.血清C反应蛋白和降钙素原检测在恶性肿瘤合并细菌感染的应用评价[J].广东医学，2017，38（15）：2342-2344.
|
| [6] |
赵栋，周建新，原口刚，等.降钙素原在心脏术后感染性与非感染性全身炎症反应综合征的鉴别诊断价值[J].中华危重病急救医学，2014，26（7）：478-483.
|
| [7] |
Marková M，Brodská H，Malícková K，et al.Substantially elevated C-reactive protein （CRP），together with low levels of procalcitonin （PCT），contributes to diagnosis of fungal infection in immunocompromised patients[J].Support Care Cancer，2013，21（10）：2733-2742.
|
| [8] |
陈炜，赵磊，王锁柱，等.炎性生物标记物在革兰氏阴性菌血流感染患者早期诊断的价值[J].中华急诊医学杂志，2014，23（3）：303-307.
|
| [9] |
郑国光.前白蛋白与C反应蛋白在新生儿感染性疾病早期诊断中的临床价值[J].中国妇幼保健，2013，28（6）：957-959.
|
| [10] |
李秋侠，李欢欢.新生儿感染性疾病危险因素分析与对策[J].中国保健营养，2016，26（5）： 93-95.
|
| [11] |
兰敏，赵艳华，饶鹏，等.小儿支气管肺炎降钙素原与C反应蛋白检测感染的临床研究[J].中华医院感染学杂志，2016，26（14）：3322-3324.
|
| [12] |
罗玮，李莉，孔繁荣，等.血清降钙素原和C反应蛋白在血流感染中的诊断价值[J].中国实验诊断学，2016，20（5）：761-764.
|
| [13] |
陈杰华，郑跃杰，王姝，等.降钙素原和C-反应蛋白对儿童全身和局部细菌感染的诊断价值[J].中国循证儿科杂志，2013，8（2）：87-91.
|
| [14] |
王莉敏，李艳丽，乔晓亮，等.C-反应蛋白、血清前白蛋白、血清降钙素原联合检测在儿童感染性疾病中的应用[J].中华医院感染学杂志，2014，24（1）：253-254.
|
| [15] |
周素芽，王丽娜，周琴，等.血清降钙素原与超敏C-反应蛋白在新生儿感染性疾病中的表达及其临床评价[J].中华医院感染学杂志，2016，26（12）：2837-2839.
|
|
|
|
