右美托咪定复合舒芬太尼和单纯舒芬太尼在妇科腹腔镜手术患者术后镇痛中的效果对比

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Abstract Objective To compare the clinical effect of Dexmetodetonidine with Sufentanil and Sufentanil alone in postoperative analgesia after gynecologic laparoscopy.Methods From June 2016 to June 2017,a toatl of 90 patients undergoing general anesthesia for gynaecological laparoscopic surgery in our hospital were selected as subjects.They were randomly divided into observation group and control group according to the random number table method,with 45 cases in each group.The observation group was treated with Sufentanil(1.5 μg/kg)combined with Dexmetodetonidine(1.0 μg/kg),and the control group was given Sufentanil(1.5 μg/kg)alone.The visual analogue scale (VAS)score,comfort scale(BCS)score,calm degree(Ramsay)score,total dose of Sufentanil consumption,and incidence of adverse reactions were compared between two groups.Results The VAS scores at 2,6,12 and 24 h after operation of the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05),there were no statistically significant differences in VAS scores between two groups at 48 h after operation (P>0.05).Ramsay scores at 2,6 and 12 h after operation of the observation group were lower than those in the control group,BCS scores at 2,6 and 12 h after operation of the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in BCS scores and Ramsay scores between two groups in 24 and 48 h after operation (P>0.05).There were statistically significant differences in VAS scores,BCS scores,and Ramsay scores at 6,12,24 and 48 h after operation of two groups compared with 2 h after operation (P<0.05).The Sufentanil consumption dose was less than that in the control group at different time points after operation,and rate of adverse reaction in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion Dexmedetomidine combined with Sufentanil is more effective than Sufentanil alone in postoperative analgesia after gynecologic laparoscopy and has a high degree of safety,which can reduce the dosage of Sufentanil for analgesia and is worthy of clinical application.

Key words： Anesthesia Postoperative analgesia Sufentanil Dexmetoprodine Laparoscopic surgery

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	Articles by authors
	MAI Wei-liang
	ZHANG Min-sen
	CHEN Rong-qiang
	HUANG Xiao-hua

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MAI Wei-liang,ZHANG Min-sen,CHEN Rong-qiang, et al. Effect comparison of Dexmetodetonidine with Sufentanil and Sufentanil alone in postoperative analgesia after gynecologic laparoscopy[J]. 中国当代医药, 2018, 25(20): 121-124.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I20/121

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