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| Changes and significance of vitamin D in the treatment of girls with central precocious puberty |
| CHEN Hua-qin1 DENG Xiao-jun1 WU Jin-hua2 |
1.Department of Paediatrics,Central Hospital of Jiangmen City (Jiangmen Hospital Affiliated to Sun Yat-sen University),Guangdong Province,Jiangmen 529030,China;
2.Department of Laboratory,Central Hospital of Jiangmen City(Jiangmen Hospital Affiliated to Sun Yat-sen University),Guangdong Province,Jiangmen 529030,China |
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Abstract Objective To observe the changes and significance of vitamin D concentration in girls with central precocious puberty （CPP）before and after treatment with gonadotropin releasing hormone analogue.Methods From January 2014 to September 2017,49 girls with CPP were selected as study group.And another 49 healthy girls were selected as control group.The vitamin D levels in two groups were measured,and the study group was divided into two groups according to the vitamin D level：study group Ⅰnormal Vit D and study group Ⅱ with Vit D deficiency.The changes of vitamin D concentration in two groups before and after treatment with GnRHa analogue were observed and compared.And the clinical significance was analyzed.Results The level of vitamin D in the study group was significantly lower than that in the control group,and the vitamin D level in the study groupⅡwas significantly lower than that in the study groupⅠ (P<0.05).After 6 months of treatment,the levels of vitamin D in study groupⅠand groupⅡwere all decreased,and the level of vitamin D in groupⅡ was significantly lower than that in groupⅠ,the differences were statistically significant(P<0.05).The rate of breast development stopped or subsided after GnRHa treatment in the study groupⅠ was significantly higher than that in the study group Ⅱ (P＜0.05）.Conclusion Vitamin D level is generally low in children with CPP,and vitamin D level will decrease in the course of treatment with GnRHa analogue,and vitamin D level has a certain influence on the effect of clinical GnRHa in the treatment of breast development regression.Therefore,adequate vitamin D supplementation is very necessary.
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