中国当代医药

中国当代医药

Home

中文

中国当代医药

Forthcoming Articles

Advanced Search

Download Articles

Quick Search


2016 Vol. 23, No. 24 Published: 2016-08-28

	4	Ischemia preconditioning decrease Cyt c release from mitochondria to cytosol through NMDA receptor in hippocam pal CA1 region
		WANGMei;HU Xiao-tong;QIDa-shi;WANG Lei;ZHANG Fang
		Objective To explore the influence of NMDA receptor specific inhibiter MK801 on the Cyt c release from mitochondria to cytosol in hippocampal CA1 of rats in cerebral ischemia/reperfusion，ischemia preconditioning and preischemia preconditioning.Methods The whole cerebral ischemia and ischemia preconditioning model were established by 4-vessel occlusion in adultmale Sprague-Dawley（SD）rats，the rats in the administration group before ischemic preconditioning for 60minuteswas given intraperitoneal injection of MK801 3mg/kg.SD ratswere randomly divided into the sham operation group，the cerebral ischemia/reperfusion group，the cerebral ischemia/reperfusion plus normal saline group，the MK801 treatment before ischemia preconditioning group，the normal saline treatment before ischemia preconditioning group and the ischemia preconditioning group.Whether themitochondria and cytosol were successfully separated in the experiment was demonstrated by detecting the distribution of themitochondrialmarker protein COXⅣ in the isolated mitochondria and corresponding cytosolic fractions.The mitochondrial components of the CA1 neurons in the hippocampus of different treatment groups and the level of Cyt c and COXⅣin the corresponding cytosolic fractions was analyzed by using immunoblotmethod.Results Mitochondria and cytosolwere separated successfully，COXⅣwas only foundin themitochondrial fractions of each group，and the COXⅣ immune activity were not detected in the cytoplasmic fractions of each group.Compared with the sham operation group，the release of Cyt c from mitochondria to cytosol in the cerebral ischemia/reperfusion group was significantly increased，with significant difference（P＜0.05）.Compared with cerebral ischemia/reperfusion group，the release of from mitochondria to cytosol in the ischemia preconditioning group was significantly decreased，with significant difference　（P＜0.05）.Compared with the ischemia preconditioning group，the release of Cyt c from mitochondria to cytosol in the MK801 treatment before ischemia preconditioning group was significantly increased，with significant difference（P＜0.05）.Conclusion Ischemia preconditioning can obviously depress the release of Cyt c from mitochondria to cytosol induced by cerebral ischemia/reperfusion through NMDA recepter，which provides a theoretical basis for clinical treatment of cerebral ischemia/reperfusion injury.
		2016 Vol. 23 (24): 4-7 [Abstract] ( 155 ) HTML (41 KB) PDF (0 KB) ( 31 )

	8	Content determination of loganin in Yishenguben capsule by RP-HPLC method
		LIJun;LIJun-ya;WU Mei-qing
		ObJective To establish amethod for determination of loganin content in Yishenguben capsule.Methods Shimpack-VP-ODS　（250 mm×4.6 mm，4μm）was used with acetonitrile water（20∶80）asmobile phase，the flow rate was 1.0 ml/min，the detection wavelength was at 240 nm.Results The linear range of loganin from 4.65 to 21.75μg was good，the average recovery ratewas 99.2%，RSD was 3.75%.Conclusion The experiment shows that thismethod has good repeatability and accurate result，and can be used in the capsule product quality control．
		2016 Vol. 23 (24): 8-10 [Abstract] ( 138 ) HTML (37 KB) PDF (0 KB) ( 4 )

	11	Immunologicalmechanism of pregnancy hypertension disease
		YU Liang;FENG Han;YU Ying-hui
		Pregnancy hypertension disease is one of themain diseases causing the death of thematernal and perinatal infant，and the causes are not clear，which makes that it has been become now research hotspot.The research focuses on the phase relation of immune，apoptosis，histocompatibility and hormone etc.But the pathogenesis can′t be explained by monism.Immune factors have evident influence on the local and thewhole body，so immune factors receive increased attention.Therefore，the papermainly observes the immunologicalmechanism of pregnancy hypertension disease.
		2016 Vol. 23 (24): 11-14 [Abstract] ( 142 ) HTML (52 KB) PDF (0 KB) ( 14 )

	15	Research progress on treatment for chronic renal failure with Chinese herbal com pound
		WANG Ling-ling;DING Dou;DONG Xiao-jun;LIZheng-sheng;WANG Ye;LIU Hou-ying
		Chronic renal failure　（CRF）is the common final outcome of different chronic kidney diseases in persistent progress and the incidence of CRF has been risng in recent years.In recent years，manymedical practitioners using Chinese herbal compound in slowing down chronic renal failures′process carried out extensive research，which has achieved satisfactory results.This article is tomake a detailed overview of treating CRF with Chinese herbal compound on the therapeuticmethods，experimental research，clinical research and curative effectevaluation etc..
		2016 Vol. 23 (24): 15-18 [Abstract] ( 162 ) HTML (50 KB) PDF (0 KB) ( 31 )

	19	Analysis of clinical data of 140 hematological disease patients com p licated with infection
		LIYi-zhen
		Objective To explore the infection-related factors，the location of infection in hematological disease patients complicated with infection so as to provide clinical reference for reduction of the infection rate.Methods 140 patients with hematological diseases complicated with infection in our hospital from June 2011 to September 2013 were selected as the research group.The index of the factors of infection，the location of infection，pathogenic bacteria and other indicatorswas analyzed.Results The infection rate in patientsmore than 60 years old and less than or equal to 3 years old were 37.86%and 32.86%respectively，which was higher than that of other age group，with significant difference　（P＜0.05）.The infection rate in patients whose chemotherapy duration more than 14 days，hospitalization stay more than 21 days and white blood cell less than or equal to 1.0×109/L were higher than that of patients whose chemotherapy duration less than or equal to 14 days，hospitalization stay less than or equal to 21 days and white blood cellmore than 1.0× 109/L（65.71%versus 34.29%，74.29%versus 25.71%and 55.71%versus 44.29%respectively），with statistically significant difference　（P＜0.05）.The infection rate in different sites　（including the respiratory tract，blood，oral cavity，urinary tract，digestive tract，skin and crissum）was 32.86%，20.00%，16.43%，14.29%，9.29%and 7.14%respectively.The infection rates of Gram-negative bacteria，Gram-positive bacteria and fungiwere 55.71%，35.00%and 9.29%，with significant difference（P＜0.05）.Conclusion The patientswith hematological diseases complicated with infection aremainly associated with age，chemotherapy duration and hospitalization stay，white blood cells，etc..The infection sites include respiratory tract，blood，oral cavity and urinary tract，which aremainly infected by Gram-negative bacteria.
		2016 Vol. 23 (24): 19-21 [Abstract] ( 132 ) HTML (35 KB) PDF (0 KB) ( 22 )

	22	Clinical efficacy and adverse reactions of cisp latin combined with endostar thoracic perfusion in the treatment ofmalignant p leural effusion of lung cancer
		ZOU Jun-tao;HU Zhen-zhen;CHEN Ying-lan
		Objective To explore the clinical effects and adverse reactions of cisplatin combined with endostar thoracic perfusion in the treatment ofmalignant pleural effusion of lung cancer.Methods 72 patientswith malignant pleural effusion of lung cancer in our hospital from December 2014 to November 2015 were selected and randomly divided into the study group and the control group，36 cases in each group.The control group was treated with cisplatin intrapleural infusion alone，the study group was treated with cisplatin combined with endostar thoracic perfusion.After 2 cycles of treatment，the clinical effects and adverse reaction incidence rate of the two groupswas compared，and the concentration of the pleural effusion，serum VEGF after treatment for 3 days and 7 days in the two groupswas compared.Results The total effective rate in the study group was 80.6%，which was higher than 58.3%in the control group，with significant difference　（P＜0.05）.The incidence rate of adverse reactions of the two groups was compared，and the difference was not statistically significant（P＞0.05）.The concentration of the pleural effusion，serum VEGF in the study group after treatment for 7 days was lower than that after treatment for 3 days and in the control group after treatment for 7 days，with significant difference（P＜0.05）.Conclusion The treatment effects of cisplatin combined with endostar thoracic perfusion in the treatment ofmalignant pleural effusion of lung cancer is significant，the incidence rate of adverse reaction is lower，and which can control the expression function of VEGF.
		2016 Vol. 23 (24): 22-24 [Abstract] ( 157 ) HTML (37 KB) PDF (0 KB) ( 23 )

	25	Effects study of modified electric shock therapy in treatment of patients with refractory schizophrenia
		FU Chun-peng;LIU Xing-hua;FU Chun-xia;XU Qiong
		Objective To study the clinical effects ofmodified electric shock　（MEC）therapy in treatment of patients with refractory schizophrenia.Methods 84 patients with refractory schizophrenia in our hospital from January 2014 to January 2016 were selected and divided into control group and treatment group by using random number table，and each group was 42 cases.Patients in the control group were simplely used olanzapine，and patients in the treatment group were added modified electric shock therapy on the basis of olanzapine.The treatment effects，time ofmental state return to normal，total duration of treatment for schizophrenia，adverse effects in treatment period and improve degree of PANSS score between two groupswere compared.Results Timemental state return to normal and total duration of treatment for schizophrenia in the treatment group were obviously shorter than those in the control group，and the difference was statistically significant（P＜0.05）.The treatment effects in the treatment group were obviously better than those in the control group，and the differenceswere statistically significant（P＜0.05）.During the treatment，adverse reaction in the treatment group were obvious less than those in the control group，and the difference of rate of adverse reaction was statistical significance（P＜0.05）.The improve degree of PANSS score before and after treatment had statistical significance（P＜0.05）in two group；after treatment，the improve degree of PANSS score in the treatment group was obvious higher than that in the control group，and the difference was statistically significant（P＜0.05）.Conclusion The clinical effects of usingmodified electric shock therapy in patientswith refractory schizophrenia are very obvious.
		2016 Vol. 23 (24): 25-27 [Abstract] ( 150 ) HTML (37 KB) PDF (0 KB) ( 7 )

	28	Clinical efficacy observation of atorvastatin combined with Danhong injection in the treatment of cerebral ischemia caused by vertebral-basilar atherosclerosis
		NA Li-sha;LIZhao-sheng;YU Long-mei;ZHAO Yu-mei;ZHENG Shuai
		Objective To analyze the clinical effects of atorvastatin combined with Danhong injection in the treatment of cerebral ischemia caused by vertebral-basilar atherosclerosis.Methods Altogether 70 cases of patientswith cerebral ischemia caused by vertebral-basilar atherosclerosis who were treated in our hospital from June 2015 to January 2016 were selected as study object and divided into conventional group and experimental group in accordance with the computer randomly groupingmethod，with 35 cases in each group，patients in conventional group received conventional therapy，while patients in experimental group were administered with atorvastatin and Danhong injection based on the conventional therapy.The clinical efficacy，adverse reaction occurrence rate，as well as the peak blood flow velocity of left vertebral artery，right vertebral artery and basilar artery between two groups were analyzed and compared.Results The total efficiency of conventional group was 77.14%，significantly lower than 94.28%of experimental group with a statistical difference　（P＜0.05）.And the peak blood flow velocity of left vertebral artery，right vertebral artery and basilar artery between two groups showed significant difference（P＜0.01）.Occurrence rate of adverse reaction between two groups was no significant difference（P＞0.05）.Conclusion Atorvastatin combined with Danhong injection shows remarkable clinical efficacy in the treatment of cerebral ischemia caused by vertebral-basilar atherosclerosis，which can effectively relieve the patient′s headache，dizziness，blurred vision and other clinical symptoms.
		2016 Vol. 23 (24): 28-30 [Abstract] ( 142 ) HTML (35 KB) PDF (0 KB) ( 37 )

	31	Diagnostic value of combined detection of Vitamin B12and Homocysteine in subacute combined degeneration of spinal cord
		YU Yin;CHEN Cheng-fang;ZONG Hui-hua;SONG Xue-xiang
		Objective To evaluate the value of combined detection of Vitamin B12and Homocysteine　（Hcy）in subacute combined degeneration of spinal cord（SCD）.Methods 30 patients with SCD from January 2010 to December 2015 in neurology department of our hospitalwere selected into SCD group，and 30 healthy persons during the same period were randomly selected into control group from medical examination center of our hospital.Serum Hcy and Vitamin B12levels of two groupswere tested and compared.Results The concentration of Vitamin B12in SCD group was lower than that in control group（P＜0.05）.The concentration of Hcy in SCD group was higher than that in control group（P＜0.05）.The sensitivity rates of Vitamin B12and Hcy in SCD was 68.6%，72.4%respectively，the specific rateswas 45.3%，41.2%respectively.In combined assay of Vitamin B12and Hcy，the sensitivity rate was 93.8%，the specificity rate was 64.3%.Comparingwith the single assay，combined detection had much higher diagnostic sensitivity.Conclusion The detection of Vitamin B12and Hcy respectively is significant in diagnosis of SCD.Combined detection of Vitamin B12and Hcy can improve the diagn-ostic rate of early SCD.
		2016 Vol. 23 (24): 31-33 [Abstract] ( 139 ) HTML (41 KB) PDF (0 KB) ( 6 )

	34	App lication of"dot sign"in early prediction of expansion of intracranial hematoma
		WANGMing-qi;LIGuang-sheng;ZENG Xiang-jun;TIAN Yun-sheng;SUNWei
		Objective To explore the predictive value of"dot sign"formed by contrast agents extravasation during delayed contrast-enhanced CT scan on expansion of intracranial hematoma at an early stage.Methods Thirty patientswith acute and spontaneous intracerebral hemorrhage within 6 hours accepted the detection in their own will in our hospital from January 2013 to December 2015 were selected and provided with baseline CT scan，delayed contrast-enhanced CT scan and CT scan for reexamination after 24 hours.According to outcomes of"dot sign"，patientswere divided into positive"dot sign"group and negative"dot sign"group.Results There were 13 and 17 cases in positive"dot sign"group and negative"dot sign"group respectively.The positive and negative predictive value was 76.9%and 94.2%respectively.Conclusion"Dot sign"formed by contrast agents extravasation during delayed contrast-enhanced CT scan can effectively predict the expansion of intracranial hematoma atan early stage.
		2016 Vol. 23 (24): 34-36 [Abstract] ( 153 ) HTML (41 KB) PDF (0 KB) ( 32 )

	37	Recent effect of basal ganglia hemorrhage by transcranial puncture treatment
		FU Guang-hui;WANG Jian-wei;WANGWen-xue;KANG Xin;LIU Yu-liang;YUAN Tao
		Objective To explore the recent effects of basal ganglia　hemorrhage by transcranial puncture treatment. Methods 58 patients with basal ganglia hemorrhage treated in our hospital from June 2013 to December 2015 were randomly divided into conservative group　（n=25）and puncture group　（n=33）.Patients in the conservative group were given conventionalmedical treatment，including timely reducing intracranial pressure，controling blood pressure，nurturing nerve and symptomatic and supportive treatment etc，patients in the puncture group were treated by a YL-l type disposable intracranial hemorrhage smash puncture needle on basic of conventionalmedical treatment，patients in two groups were followed up for 3months，the fatality rate and activities of daily life　（ADL）in two groupswere recorded and compared.Results The fatality rate in the puncture group was 15.2%，with 32.0%in the conservative group，the difference was significantly significant（P＜0.05）；survivors′ADL grade ADL1-3accounted for 71.4%in the puncture group，which was 35.3%in the conservative group，which showed significant difference　（P＜0.05）.Conclusion YL-1 type disposable intracranial hemorrhage smash puncture needle in treatment of basal ganglia hemorrhage is a simple，fast and accurate positioning，less traumati，low fatality rate and deserves to be promoted for clinical performance.
		2016 Vol. 23 (24): 37-39 [Abstract] ( 138 ) HTML (36 KB) PDF (0 KB) ( 20 )

	40	Report of sudden cardiac death of one case with alcohol related seizures
		FAN Zhen;FENGQin
		Objective To enhance awareness of causes of sudden cardiac death in patientwith alcohol related seizures （ARS）.Methods Case data of sudden cardiac death in a patientwith ARSwas analyzed and reviewed.Results The patients had 40 years of drinking history and repeated quit drinking in 4 years bymyself，admitted to hospital because of mental and behavioral abnormalities for two times，he been diagnosed as alcohol withdrawal syndrome and then drank again.Because nobody was at home one day before the patient was ill，so it was not clear whether the patient quited drinking again.The patientwas admitted to hospital due to repeated systemic paroxysmal convulsions and calling without any answers for 2 hours.Corresponding treatmentswere according to alcoholic encephalopathy and generalized tonic clonic seizures.The patient was dead with sudden cardiac after epilepsy controlling and conscious improvement.Conclusion Patients with alcohol dependence are prone to epileptic seizure，then can induce arrhythmia.The risk of death was significantly higher than that of other crowd.For these Patients，early quit drinking，closemonitoring cardiac function after epileptic seizure and early intervention treatment should be done to prevent the occur of sudden cardiac death.
		2016 Vol. 23 (24): 40-42 [Abstract] ( 118 ) HTML (34 KB) PDF (0 KB) ( 35 )

	43	Effects analysis of paroxetine hydrochloride combined with olanzapine in treating obsessive-com pulsive disorder
		HUANG Sheng-wan
		Objective To analyze the feasibility and safety of paroxetine hydrochloride combined with olanzapine in treating obsessive-compulsive disorder.Methods 82 patients in mental and psychological clinic of our hospital from February 2013 to February 2016 were selected and divided into observation group and control group according to different treatmentmethods，and each group was 41 cases.Patients in the control group were used paroxetine hydrochloride，and patients in the observation group were used olanzapine on the basis of control group.The treatment effects and adverse effects in two groups were compared by using Y-BOCS and the incidence of adverse effects in two groups was compared by using HAMA.Results The total effective rate in the observation group and the control group was respectively 87.80%（36/41）and 69.29%（28/41），and the difference was statistical significance（P＜0.05）；in the treatment for the 2ndmonths，HAMA and Y-BOCS in the observation group were lower than those in the control group，and the difference was statistical significance（P＜0.05）；the blood glucose and blood lipid in two groups before and after treatment had no difference（P＞0.05）；at the same time，patients in two groups had gastrointestinal reaction and stomach discomfort，and symptomatic treatment eased　（P＞0.05）.Conclusion Paroxetine hydrochloride combined with olanzapine in treating obsessive-compulsive disorder has obvious effects and with safety，which is an effective method and is worth popularize and application in clinic.
		2016 Vol. 23 (24): 43-45 [Abstract] ( 135 ) HTML (37 KB) PDF (0 KB) ( 29 )

	46	Com parison on the effect of mini plate and Kirschner wire internal fixation in treatingmetacarpal and phalangeal fracture
		ZHANG Cui;WEN Qin;GAN Xin-rong;LEIMing;HE Zhen-yu;YU Bo;HUANG Qiang
		Objective To compare the effect of mini plate and Kirschner wire internal fixation in treating metacarpal and phalangeal fracture.Methods 78 metacarpal and phalangeal fracture patients from February 2014 to May 2015 of our hospitalwere retrospective analyzed.Patientswere divided into study group and control group according to the differentmethods，and each group was 69 cases.Patients in study group were used mini plate and patients in control group were used Kirschnerwire.Postoperative hand function recovery rate and incidence of postoperative complications in two groupswere compared and the effectswere judged comprehensively.Results The good rate for fracture healing in study group was 94.8%，which was significantly higher than that in the control group　（69.2%）；the incidence of complication was 5.2%，which was significantly lower than that in the control group（25.7%）（P＜0.05）.Conclusion In the treatment of metacarpal and phalangeal fracture，the effect of usingmini plate fixation are obvious better than using Kirschner wire internal fixation，and with positive clinical treatment value.
		2016 Vol. 23 (24): 46-48 [Abstract] ( 129 ) HTML (39 KB) PDF (0 KB) ( 42 )

	49	Feasibility and safety of Expert tibial intramedullary nail treatment for Tibialmetaphyseal fractures patients
		MO Jing-sheng;YE Yong-sheng;LIANG Hao-biao
		Objective To investigate feasibility and safety of expert tibial intramedullary nail treatment for tibialmetaphyseal fractures patients.Methods In our hospital，84 cases of tibial metaphyseal fractures patients from December 2013 to December 2015 were randomly divided into research group and control group，42 cases in each group.Control group were treated limited open locking plate fixation，while research group were treated with expert tibial intramedullary nail fixation.The operation time，blood loss，hospital stay time，full load time，Joher-Wruhs effect and complication rate of the two groups were compared.Results There was no significant difference in operation time and blood loss between the two groups（P＞0.05）.The hospital stay time and full load time of research group were shorter than those of control group　（P＜0.05）.5 weeks after treatment，the Joher-Wruhs effect of research group was better than that of control group　（P＜0.05）.There was no complication in the two groups.Conclusion Expert tibial intramedullary nail treatment has exact effect for tibialmetaphyseal fractures patients.It can promote postoperative rehabilitation and has no complication and is safe and reliable.
		2016 Vol. 23 (24): 49-51 [Abstract] ( 136 ) HTML (36 KB) PDF (0 KB) ( 2 )

	52	Clinical study ofmodified posterior lumbar interbody fusion in the treatment of senile lumbar spinal stenosiswith lower lumbar spine instability
		NINGMing-liang
		Objective To study the clinical effect of application ofmodified posterior lumbar interbody fusion（PLIF）in the treatment of elderly patients with lumbar spinal stenosis complicated with lower lumbar spine instability.Methods 35 cases of elderly patients with lumbar spinal stenosis complicated with lower lumbar spine who were treated in the hospital from June 2010 to January 2015 were selected and randomly divided into the two groups with 17 cases in observation group and 18 cases in control group.Control group was treated with conventional PLIF，while observation group was treated with modified PLIF.The clinical effect of the two groups was compared.Results The total effective rate of observation group treated with themodified PLIF was 94.4%，significantly higher than that of control group（64.7%）（P＜0.05）.The postoperative fusion rate of observation group was higher than that of control group and the adjacent segment degeneration rate of observation group decreased significantly in comparison with control group　（P＜0.05）.Conclusion Application of modified PLIF for elderly patients with lumbar spinal stenosis complicated with lumbar instability obtains equivalent decompression effects and also retains the rear part of the structure.It achieves better vertebral stability and clinical effects，and improves the intervertebral fusion rate，which deserveswider clinical application.
		2016 Vol. 23 (24): 52-54 [Abstract] ( 135 ) HTML (37 KB) PDF (0 KB) ( 30 )

	55	Clinical effect and　biomechanical study　of intramedullary　and　intramedullary fixation in the treatment of femoral intertrochanteric fractures
		YUAN Dan
		Objective To investigate the clinical effect and biomechanical characteristics of the modified proximal femoral nail anti-rotation（PFNA-Ⅱ）and dynamic hip screw（DHS）in the treatment of femoral intertrochanteric fractures.Methods 60 cases of patients with femoral intertrochanteric fractures who were treated in department of orthopedics in the hospital from September 2011 to September 2015 were selected and divided randomly into two groups according to the random number tablemethod.The effects，length of incision，amount of intraoperative bleeding，surgicalduration，postoperative complicationrate of PFNA-Ⅱ group（treated with PFNA-Ⅱ，n=30）and DHS group（treated with DHS，n=30）were compared.Results The total effective rate of the femoral intertrochanteric fractures was 96.7%，and therewas no difference between PFNA-Ⅱgroup and DHSgroup（93.3%）（P＞0.05）.The length of incision，the amount of intraoperative bleeding and surgicalduration of PFNA-Ⅱgroup was less than that of DHS group respectively，with statistical differences（P＜0.05）.Only 1 case of pulmonary infection occurred in PFNA-Ⅱgroup，with the complicationrate accounting for 3.3%in PFNA-Ⅱgroup；two cases of pulmonary infections and 1 case of hip inversion occurred in DHS group，with the complication rate accounting for 10.0%，with no difference between the two groups（P＞0.05）.Conclusion PFNA-Ⅱ demonstrates the advantages of less bleeding，shorter surgical duration，better safety and effectiveness over DHS in the treatment of femoral intertrochanteric fractures，which ismore suitable for patientswith osteoporosis and deserves greater popularization and application.
		2016 Vol. 23 (24): 55-57 [Abstract] ( 152 ) HTML (39 KB) PDF (0 KB) ( 32 )

	58	Effect com parison of interlocking intramedullary nail and dynamic compression p late for internal fixation in the treatment of bone ununion in fracture of femoral shaft
		WU Hua-bing;YIN Jin-ming;TIAN Hua-qiang
		Objective To compare the therapeutic effect of interlocking intramedullary nail for internal fixation and dynamic compression plate for internal fixation on treating bone ununion in fracture of femoral shaft.Methods From February 2011 to January 2015，76 patients with bone ununion in fracture of femoral shaft admitted into our hospital were selected.According to a random number table，they were evenly divided into group A and group B.In group A，interlocking intramedullary nail for internal fixation was applied，while in group B，dynamic compression plate for internal fixation was adopted.The operation time，amount of bleeding，volume of drainage after surgery，length of incision，short-term therapeutic effect，healing time of bone fracture，incidence of infection during follow-up visit，and knee joint function before and after treatment were compared between the two groups.Results There was no great difference in operation time or length of incision between two groups（P＞0.05）.The amount of bleeding and volume of drainage after surgery in group A was obviously less than that in group B respectively（P＜0.05）.In group A，healing time of bone fracture was shorter in comparison with that in group B（P＜0.05）.The incidence of infection in group A was lower compared with that in group B（P＜0.05）.The total effective rate in group A wasmuch higher than that in group B（P＜0.05）.There was no significant difference in score of knee joint function before treatment in both groups（P＞0.05）. However，after therapy，the score of knee joint function in group A was remarkably higher than that in group B（P＜0.05）. Conclusion Compared with dynamic compression plate for internal fixation，interlocking intramedullary nail for internal fixation can obtain better short/long-term effects on treating bone ununion in fracture of femoral shaft with recovery sooner and lower infection incidence.
		2016 Vol. 23 (24): 58-61 [Abstract] ( 134 ) HTML (42 KB) PDF (0 KB) ( 19 )

	62	The clinical efficacy of proximal humeral internal locking systemin treatment of proximal humeral fracturesin elderly patients
		ZHANG Chuan-hui
		Objective To investigate the clinical effect of proximal humeral internal locking system（PHILOS）in treatment of proximal humeral fractures in elderly patients.Methods 89 cases of elderly patients with proximal humeral fractureswho were hospitalized in our hospital from January 2010 to December 2014 were selected as our object.They were divided into the PHILOSgroup（45 cases）and the control group（44 cases）by treatmentmethods.The patients in the PHILOSgroup were treated with PHILOSand the patients in the control group were treated with locking plate fixation. The duration of operation，intraoperative blood loss，postoperative complicationsin between two groups were recorded.The recovery of shoulder joint function were compared between PHILOSgroup.The recovery of shoulder joint function were evaluated with Neer evaluation criteria and control group 1 year after operation.Results The duration of operation in PHILOSgroup［（61.5±13.9）min］was shorter than that in control group［（91.5±14.0）min］（P＜0.05）.The intraoperative blood loss in PHILOSgroup［（198.2±26.9）ml］was less than that in control group［（276.6±25.8）ml］（P＜0.05）.The postoperative complicationsin PHILOSgroup（4.4%）was lower than that in control group（20.4%）（P＜0.05）.In PHILOSgroup，best shoulder joint function was in 24 cases（53.3%），good in 18 cases（40.0%），general in 3 cases（6.7%），poor in 0 case.In control group，best shoulder joint function was in 12 cases（27.3%），good in 15 cases（34.1%），general in 10 cases（2.7%），poor in 7 cases（15.9%）.The excellent rates of the two groupswere 93.3%and 61.4%respectively the differencewas statistically significant（P＜0.05）.Conclusion PHILOShas the advantages of less damage and good recovery of shoulder joint function with locking plate fixation in treatment of proximal humeral fractures in elderly patients.This treatment is worth clinical promotion.
		2016 Vol. 23 (24): 62-64 [Abstract] ( 147 ) HTML (35 KB) PDF (0 KB) ( 31 )

	65	Com parison of the effect of non operative treatment and surgical treatment for humeral surgical neck fracture
		XU Bin-feng;ZHOU Zao-fa;JIANG Xin-hao;ZHU You-gui
		Objective To explore the clinical effects of humerus surgical neck fracture technique repair and small splint external fixation and open reduction and internal fixation.Methods 80 humerus surgical neck fracture patients from February 2015 to February 2016 of our hospital were selected.Patients were divided into group A and group B according to the different treatmentmethod，and each group was 40 cases.Patients in group A were used technique repair and small splint external fixation，and patients in group B were used open reduction and internal fixation.The clinical effects，complications，the length of bone healing time，improvement of joint function and recurrence rate between two groups were compared.Results The treatment effects in group B　（95.00%）was better than that in group A　（80.00%），the incidence rate of complications（5%）was lower than that in group A（20%），length of bone healing time［（41.89±4.88）d］was shorter than that of group A［（49.01±5.02）d］，improvement of joint function was better than that of group A，and the recurrence rate（2.5%）was lower than that of group A（15.0%），and the difference between two groupswas obvious and statistical significance（all P＜0.05）.Conclusion Both of humerus surgical neck fracture technique repair and small splint external fixation and open reduction and internal fixation have good effects for humerus surgical neck fracture patients，which have great guiding significance for treatmentof humerus surgical neck fracture patients in clinic.
		2016 Vol. 23 (24): 65-67 [Abstract] ( 137 ) HTML (37 KB) PDF (0 KB) ( 32 )

	68	Evaluation on the effect of app lication of PCS pedicle screwin the treatment of spinal trauma related diseases
		YANG Li
		Objective To investigate the clinical effect of application of PCS（part concentrated screw）pedicle screwin the treatment of spinal trauma related diseases.Methods 69 cases of patients with spinal trauma related diseases who were diagnosed and treated in the hospital from February 2015 to February 2016 were involved as the object of this research and randomly divided into two groups on the basis of the random drawprinciple，with 35 cases in study group （treated with the PCS pedicle screw system）and 34 cases in control group（treated with the conventional spinal pedicle screw system）.The pre-and post-operative Cobb angle of damaged vertebral body，degree of pain，changes in the degree of spinal cord nerve injuries and related surgery indicators between two groupswere compared.Results The Cobb angle and pain score of study group was significantly lower than that of control group respectively（P＜0.05）.No statistical difference was revealed between the post-operative spinal cord injury rating of study group and control group（P＞0.05）.The average LOS（length of stay）of study group was（9.62±1.47）d，shorter than（13.76±1.95）d in the control group（P＜0.05）. Conclusion The PCS pedicle screw demonstrates its excellent effects in treatment of spinal trauma related diseases，remarkable correction of the damaged vertebral body structure，alleviation of the pain，improvement of spinal cord nerve functionsand promotion of the early recovery for patients，which should be taken as the preferred methods for treatment of spinal trauma related diseases.
		2016 Vol. 23 (24): 68-70 [Abstract] ( 102 ) HTML (39 KB) PDF (0 KB) ( 30 )

	71	Clinical research of related high risk factor of adverse outcome in advanced maternal
		LU Rong
		Objective To explore the high risk factor that leading to adverse outcome in advanced maternal.Metho ds 925 elderly parturientwomen，aged more than 35 years old，who been confined from May 2012 to May 2016 of our hospitalwere retrospective analyzed，and 925maternal age，aged 20-34 years old，who been confined at the same term were random selected as control.Pregnancy complications and complications，difference of perinatal outcome between elderly parturientwomen group and maternal age group were compared and analyzed.At the same time，multi factor Logistic regression analysis was used to analyze the risk factors that impacted advanced maternal delivery.Results The incidence rate of anemia，myoma of uterus，pregnancy associated with diabetes，hypertensive disorder complicating pregnancy，placenta previa and postpartum hemorrhage in advanced maternalwere higher thanmaternal age　（P＜0.01）.All of asphyxia of newborn，the incidence rate of great children and average birth weight in advanced maternalwere higher than maternal age（P＜0.05）.The difference of newbornmortality and neonatalmalformation rate between two groups had no statistical significance　（P＞0.05）.The high risk factor that impacted adverse outcome in advanced maternal were multiple pregnancy（P＜0.05），placenta previa（P＜0.01），fetal distress（P＜0.01），anemia（P＜0.05）and abnormal electrocardiogram （P＜0.05）.Conclusion Multiple pregnancy，placenta previa，fetal distress，anemia and abnormal electrocardiogram are high risk factor that resulting to adverse outcome in advanced maternal.In clinic，it should be strengthen the health care of the elderly pregnantwomen during pregnancy，timely treatmentwhen finds abnormal to reduce the occurrence of adverse pregnancy outcome and to achieve the purpose ofmaternal and child health.
		2016 Vol. 23 (24): 71-73转83 [Abstract] ( 135 ) HTML (39 KB) PDF (0 KB) ( 41 )

	74	Bifidobacterium Tetravaccine Tablets combined with blue light in the treatment of neonatal jaundice and effect on nerve，liver function
		XU De-le
		Objective To study of Bifidobacterium Tetravaccine Tablets combined with blue light in the treatment of neonatal jaundice and the effect of nerve and liver function.Methods The clinical data of 96 cases of neonatal jaundice in our hospital from May 2014 to May 2016 were retrospectively analyzed，and were randomly selected blue light irradiation as the control group，48 cases with Bifidobacterium Tetravaccine Tablets combined with blue light irradiation as the treatmentgroup.Ttwo groups of patientswith nerve function and liver function indexeswere observed and compared. Results After 3 days of treatment，the observation group was significantly lower than the control group（TCB），total bilirubin（TSB）and direct bilirubin（DB），and the results of the two groups were statistically significant（P＜0.05）；after 3 days of treatment，the serum levels of neuron specific enzyme（NSE），astrocytes（S100B）and beta amyloid（A beta）in the observation group were lower than those in the control group　（P＜0.05）；after 3 days of treatment，the observation group of aspartate aminotransferase　（AST），and alanine aminotransferase　（ALT）level was significantly lower than the control group，the results of the two groups compared with statistical significance（P＜0.05）.Conclusion For neonatal jaundice by Bifidobacterium Tetravaccine Tablets combined with blue light treatment，can effectively protect the nerve，improve liver function，worthy of clinical popularization and application.
		2016 Vol. 23 (24): 74-76 [Abstract] ( 139 ) HTML (38 KB) PDF (0 KB) ( 7 )

	77	Activin A，β-hCG，P in the value of early diagnosis of ectopic pregnancy
		ZHANGWen;ZHOU Xiu-ying;YAN Mei-rong;CHEN Li;LINing

		2016 Vol. 23 (24): 77-79 [Abstract] ( 140 ) HTML (39 KB) PDF (0 KB) ( 42 )

	80	Etiological analysis of pregnancy with thrombocytopenia and their im pact onmaternal pregnancy outcome
		HUANG Jiang-ping;DAIMing
		Objective To investigate the etiology of thrombocytopenia in pregnancy and its effect on maternal and neonatal outcomes.Methods 80 cases in our hospital in June 2013 to June 2015 were thrombocytopenia with pregnancy reduce patients as observation group，according to the platelet count the observation group was divided into observation group 1　（mild thrombocytopenia，30 cases），observation group 2　（moderate thrombocytopenia，30 cases）and observation group 3　（severe thrombocytopenia，20 cases）.Another 80 cases of normal pregnantwomen in our hospitalwere selected as control group.Pregnancy with thrombocytopenia reduce themain cause of the diseasewas analyzed，the rate of cesarean section，postpartum hemorrhage，neonatal asphyxia，index and platelet reduce disease severity and anemia，preterm delivery and postpartum complications and perineonatal outcomewas observed.Results The causes of pregnancy associated thrombocytopenia and idiopathic thrombocytopenic purpura were among the main causes of thrombocytopenia in pregnancy，respectively accounted for 61.3%and 12.5%；the observation group of cesarean section and vaginal delivery rate compared with the control group，with no significant different（P＞0.05）；the rate of neonatal asphyxia，postpartum hemorrhage rate was significantly higher than that of control group，the difference was statistically significant（P＜0.05）；the observation group had no puerperal infection，but the observation group 2 and observation group 1，observation group 3 and observation between the 2 groups，the prevalence of anemia among，with the significant different（χ2=19.224，20.256，P＜0.05）；the rate of premature birth was compared（χ2=16.336，18.198，P＜0.05）；the observation group had no neonatal intracranial hemorrhage，no death，but the average weight of newborn was compared，no statistically significant difference between groups（P＞0.05）；observation group 2 and observation group 1，observation group 3 and observation between the 2 groups，the rate of newborn thrombocytopenia was compared，with the siginificant different（χ2=16.357，17.028，P＜0.05，）and the incidence of neonatal thrombocytopenia was increased with the severity ofmaternal platelet.Conclusion Pregnancy associated thrombocytopenia and anemia，premature delivery，postpartum hemorrhage and neonatal thrombocytopenia and other indicators are closely related，should cause clinical attention.
		2016 Vol. 23 (24): 80-83 [Abstract] ( 122 ) HTML (44 KB) PDF (0 KB) ( 35 )

	84	Clinical analysis of laparoscopic hysterectomy
		FENG Jian-yi
		Objective To investigate the effect of the implementation of laparoscopic hysterectomy.Methods During April 2013 to December 2015 108 cases of obstetrics and gynecology hysterectomy in our hospital were selected.The patientswere randomly divided into two groups，the A group of patientswere treated with the implementation of laparoscopic hysterectomy，the B group were treated with abdominal hysterectomy，the clinical effectwere compared.Results A group patients operative time，hospital stay，blood loss was shorter than that of group B，the difference was statistically significant（P＜0.05）.A group patients get out of bed time，postoperative exhaust time，postoperative eating time was shorter than that of group B，comparison was statistically significant（P＜0.05）.A group having 1 case of complications，the rate was 1.85%，the occurrence of complications in group B was 8 cases，the rate was 14.81%.the difference was statistically significant（P＜0.05）.Conclusion Compared to laparoscopic hysterectomy，abdominal hysterectomy has a shorter operative time，blood loss，low-level features，and safe operation，hasworthy of clinical application.
		2016 Vol. 23 (24): 84-86 [Abstract] ( 120 ) HTML (39 KB) PDF (0 KB) ( 38 )

	87	Efficacy of nifedipine for the treatment of preeclam psia
		ZHENG Rui-fang
		Objective To explore the curative effect of Nifedipine for the treatment of preeclampsia.Methods 74 patientswith preeclampsia who had received treatment in our hospital between October 2013 and October 2015 were selected and divided into two groups according to the admission order.Control group was treated with magnesium sulfate injection，whereas the study group with Nifedipine and magnesium sulfate injection.The clinical efficacy，diastolic and systolic blood pressure，hematocrit，changes of urine protein and pregnancy outcomes in the two groups were statistically analyzed.Results The total effective rate（94.60%），neonatal asphyxia rate（2.7%），rate of cesarean section（10.8%）in the study group were all higher than those of control group（72.97%，21.6%and 40.5%respectively），and the differences were statistically significant（P＜0.05）.Therewas no statistically significant difference registered between the two groups in systolic and diastolic blood pressure，hematocrit and proteinuria content before treatment（P＞0.05）.After treatment，however，all these indexes in the study group were shown to be significantly better than those of control group，and the differences were statistically significant（P＜0.05）.Conclusion For the treatment of preeclampsia，Nifedipine combined with conventional treatment is with definite curative effect，which can effectively improve the patients′blood pressure，hematocrit，urine protein content，pregnancy outcomes and clinical effects.
		2016 Vol. 23 (24): 87-89 [Abstract] ( 122 ) HTML (39 KB) PDF (0 KB) ( 20 )

	90	The effectiveness analysis of difficult laparoscopic hysterectomy
		QU Xue-mei
		Objective To explore themethod and effect of difficult laparoscopic hysterectomy.Methods The 68 cases of hysterectomy indications and difficult surgery patientswere selected from February 2014 to August 2015 in our hospital as research subjects，and the patients were randomly divided into experimental group and control group based on the random number table method，35 cases in each group.The control group was treated by conventional abdominal hysterectomy downlink，while the observer group by difficult laparoscopic hysterectomy.The operative time，blood loss，postoperative temperature，anal exhaust recovery time，hospital time，bed time and complications were compared between two groups.Results The operative time，blood loss and postoperative temperature of the observer group were significantly less than those of control group　（P＜0.05）.The anal exhaust recovery time，hospital time and bed time of the observer group were significantly less than those of control group　（P＜0.01）.The incidence of adverse symptoms in the observer group was 8.57%and lower than that of control group 28.57%　（P＜0.05）.Conclusion The trauma and blood loss of difficult laparoscopic hysterectomy is small，benefit patients and postoperative recovery，and worthy of clinical application.
		2016 Vol. 23 (24): 90-92 [Abstract] ( 109 ) HTML (38 KB) PDF (0 KB) ( 40 )

	93	Effects of app lication of INSURE strategy and mechanical ventilation in the treatment of NRDS and their influence on the incidence of VAP
		LIWan-le;HUANG Cong-fu;TANG Yan-li;LIBo;MA Ying-ying
		Objective To investigate the effects of application of INSURE strategy，the orotracheal intubation-pulmonary surfactant（PS）-post-extubation nasal continuous positive airway pressure（nCPAP）ventilation and mechanical ventilation in the treatment of neonatal respiratory distress syndrome（NRDS）and their influence on Ventilator Associated Pneumonia（VAP）.Methods Altogether 120 cases of NRDS patients who were treated in the hospital from August 2014 to December 2015 were involved as the object of this study and divided into observation group（treated with INSURE strategy）and control group　（treated with mechanical ventilation after pulmonary surfactantadministration）according to their hospital admission sequence，with 60 cases in each group.The post-treatment arterial blood gas（ABG）and the incidence of VAP between the two groupswere compared.Results Neither group showed no significant difference in pre-ABG（P＞0.05）；while，PaO2（arterial partial pressure of oxygen）of observation group and control group at 1 h and 12 h post-treatmentwas（80.52±6.73）mmHg vs（80.41±6.55）mmHg，and（90.32±5.88）mmHg vs（90.48±6.04）mmHg respectively.No significant difference was seen between the ABG analysis results of neither group（P＞0.05）.The incidence of VAP and curative rate of observation group and control group were 1.67%vs 11.67%　（P＜0.05），and 88.33%vs 85.00%without significant difference　（P＞0.05）.Conclusion The INSURE strategy and mechanical ventilation prove equal efficacy in treatment of NRDS，among which the INSURE strategy has positive effects on reduction of the incidence of VAP in children and is suitable for popularization and application.
		2016 Vol. 23 (24): 93-95 [Abstract] ( 124 ) HTML (33 KB) PDF (0 KB) ( 21 )

	96	Retrospective analysis of TORCH infection in infertile women and sperm donors
		YANG Ning;ZHONG Xing-ming;QIN Wei-bing;MIAO Zhu-lin;WANG Yong-xia;ZHANG Zhuo-jun;CUI Rong;HUANGMi-qiong
		Objective To investigate the TORCH infection rate of infertile women and sperm donors in Guangdong area and the TORCH infection distribution in different seasons.Methods From January 2012 to June 2015，10 531 cases of infertiled women and 1505 sperm donorswere detected by enzyme linked immunosorbent assay（ELISA）for the detection of Toxoplasma，rubella virus，cytomegalovirus and herpes simplex virus IgM antibody in our hospital.Results From high to low，the positive rate of IgM TORCH antibody in infertiled women in Guangdong area was 1.7%in Cytomegalovirus，1.1%in Herpes simplex virus，1.1%in Rubella virus and 0.7%in Toxoplasma gondii，respectively.From high to low，the positive rate of IgM TORCH antibody in sperm donors was 1.8%in Cytomegalovirus，1.3%in Herpes simplex virus，1.5%in Rubella virus and 0.9%in Toxoplasma gondii，respectively.There was no significance in same pathgoen between infertile women and sperm donors，the positive rate of CMV was the highest and the positive rate of Toxoplasma gondiiwas the lowest.The total positive rate was 4.7%（563/12 036）.In different seasons，the positive rate of pathgoen has no significance difference（P＞0.05）.Conclusion There is a certain proportion of TORCH infection in the infertile population with no obvious seasonal changes，which should be widely used in health education to reduce the incidence of adverse pregnancy induced by TORCH infection.
		2016 Vol. 23 (24): 96-98 [Abstract] ( 136 ) HTML (35 KB) PDF (0 KB) ( 8 )

	99	Analysis of the effectiveness of application of ultrasonography in the diagnosis and differentiation of thyroid adenoma and nodular goiter
		XU Yun-hui;ZHONGQiu-qin;ZHU Qi-dao
		Objective To compare the image features and the diagnostic accuracy of ultrasound in thyroid adenoma and nodular goiter so as to analyze the effectiveness of application of ultrasound in the diagnosis and differential diagnosis of the two diseases.Methods From January 2014 to December 2015 altogether 120 surgically-and pathologically-diagnosed thyroid adenoma and nodular goiter patients in our hospital（60 cases of patients for each disease）were selected and divided into two groups（thyroid adenoma group and nodular goiter group）according to the different diagnostic results.Color doppler ultrasonic examinations of the two groups of patientswere performed so as to observe the size，shape，quantity，capsule and surrounding tissue and blood flow signal of thyroid lesions and compare the image features of the two groups.Results The diagnostic accuracy rate of nodular goiter was 93.3%，and the diagnostic accuracy rate of thyroid adenoma was 90.0%.The ultrasound imaging features of the two groupswere significantly different（P＜0.05）.The distribution of ultrasonic blood flow signal classification of two groups showed obvious significant differences（P＜0.05）. Conclusion Various ultrasound image characteristics of nodular goiter and thyroid adenoma are significantly different. Doppler ultrasound blood flow signal classification can help doctors to analyze the ultrasound images of thyroid adenoma group and nodular goiter group，which is also helpful for differential diagnosis of the two diseases and can provide an important basis for the clinical diagnosis and treatmentof thyroid diseases.
		2016 Vol. 23 (24): 99-101 [Abstract] ( 142 ) HTML (38 KB) PDF (0 KB) ( 30 )

	102	The role of bedside DR chest X-ray in the diagnosis of 1000 cases of patientswith intensive care unit
		WANGWen-shang;LEIJian-ming;ZHAO Chong-qing;WANG Yu-hao;MAIYuan-qi
		Objective To explore the clinical significance of bedside DR chest X-ray examination in 1000 cases of intensive care unit.Methods 1000 patients from June 2014 to December 2015 in our hospital intensive care unit were selected as the research object and the bedside DR chest radiography was carried out to detect the patients，and the results were compared.Results 1000 intensive care patients，bedside DR chest radiograph detection rate of diseases such as atelectasis，pulmonary edema，pneumonia，pericardial effusion，pleural effusion was 99.30%which waswigher than that in the non-detection rate（0.70%），the difference was statistically significant（P＜0.05）.Bed DR chest radiograph diagnosis of atelectasis，pulmonary edema，pneumonia，pericardial effusion，pleural effusion was 34.20%，23.60%，18.40%，5.80%，15.30%and pathological diagnosis results was 34.50%，23.80%，18.30%，5.60%，15.50%，therewasno statistical significance　（P＞0.05）.The observation group quality piecewas 903，918 in the control group，the observation group highquality ratewas slightly lower than that in the control group，but no significant difference between groups（χ2=1.203，P= 0.273）.Conclusion In intensive care patients significantly，the clinical significance of the implementation of bedside DR chest X-ray detection can improve the diagnostic accuracy，safety and reliability，satisfaction is higher，which isworthy of popularization and application.
		2016 Vol. 23 (24): 102-104 [Abstract] ( 126 ) HTML (39 KB) PDF (0 KB) ( 23 )

	105	Com pulsion research of ultrasonic evaluation and left ventricular angiography in transcatheter closure of ventricular septal defect
		ZHONG Yong;ZHAO Xin;LIYu-jiao
		Objective To explore the diagnosis research of ultrasonic evaluation and left ventricular angiography in transcatheter closure of ventricular septal defect.Methods Patientswho was hospitalized in our hospital and were diagnosed as ventricular septal defect and treated with transcatheter closure of ventricular septal defect from January 2013 to December 2015 were evaluated with ultrasonic and left ventricular angiography.The accuracy rate and the distance between the VSD and the aortic valve of two methods were compared.Results The match number，error and accuracy rate of ultrasonic were respectively 50，10 and 83.3%，which were respectively 54，6 and 90.0%of left ventricular angiography，and the accuracy rate of ultrasonic had statistical significance compared with left ventricular angiography　（P＜0.05）.The distance between the VSD and the aortic valve tested by ultrasonic and cardiovascular angiography were respectively（2.13±1.47）mm and（2.93±1.33）mm，and the difference was statistical significant（P＜0.05）.Conclusion Left ventricular angiography has higher accuracy rate in diagnosis ventricular septal defect，which can facilitate the doctor to guide the interventional operation；ultrasonic has the advantages of economy and accuracy，the effect will bemore obvious if combination the twomethods.
		2016 Vol. 23 (24): 105-106转123 [Abstract] ( 99 ) HTML (31 KB) PDF (0 KB) ( 30 )

	107	Influence on fetus prognosis of the degree of lateral ventricleswidened
		LINWen-bi
		Objective To explore the correlation between the degree of enhancement of the lateral ventricles and the prognosis of the fetus by ultrasonography.Methods 150 cases of lateral ventricle increased width of fetus and corresponding pregnantwomen were chosen from January 2011 to May 2015 between our hospital，and were singleton pregnancy，gestational age 23-25 weeks after firstmeasurement of fetal lateral ventricle width and fetal lateral ventricle increased wide degree between the 10-15 mm，116 cases ofmild group and 34 cases ofmoderate group according to the lateral ventricle broadening degree and mild group，fetal growth degree ofwide in 10-12 mm and moderate group fetal increasing wide degree between the 12.1-15 mm，the scope of the fetus width were not included in the scope of this study，two groups of fetuses diagnosed to delivery process in the lateral ventricle variable degree were observed and birth outcomes were compared.Results To puerperal delivery or abortion，group ofmild fetal lateral ventricle had improved obvious than that in themoderate group，and the difference was statistically significant（P＜0.05）；fetal normal delivery rate and neonatal health rate ofmild group was 94.8%and 90.5%，which was significantly higher than that of the moderate group with 88.2%and 73.5%，the differencewas statistical significance（P＜0.05）；mild group neonatal abnormal rate was 3.4%，which was significantly lower than that of 20.6%of the moderate group，the difference was statistically significant（P＜0.05）.Conclusion Observation of ultrasound diagnosis of fetal lateral ventricle widened can detailly observate the fetal lateral ventricle increased wide improvement，evaluate the prognosis of the fetus and pregnancy outcome with a certain extent，and to provide a basis for clinic，it isworthy of promotion and application in clinic.
		2016 Vol. 23 (24): 107-109 [Abstract] ( 134 ) HTML (35 KB) PDF (0 KB) ( 30 )

	110	Analysis on the significance and method of pharmaceutical intervention of quinolones antibacterial drugs in clinical app lication
		WU Zhi-zhong
		Objective To analyze the pharmacy interventionmethods of quinolones antibacterial drugs clinical application，and to explore the value of pharmaceutical intervention in quinolone antibacterial drugs in clinical application. Methods 2000 cases of quinolone antibiotic prescription from January to December in 2014 in our hospital without pharmaceutical intervention were selected as the control group，and 2000 pieces of quinolone antibacterial drugs prescription from January to December in 2015 in our hospital with pharmaceutical intervention were selected as the observation group.The control group had not carried out pharmaceutical intervention，the prescription was reviewed，the unqualified prescriptions were summarized and analyzed.The observation group had implemented the corresponding drug intervention according to the reasons of the control group.The unqualified prescription rate，frequency of use of quinolones drugs，drug utilization index was compared between the two groups.Results The unqualified prescription rate in the observation group was 9.10%，which was lower than 12.85%in the control group，with significant difference　（P＜0.05）.The frequency of use of quinolones drugs，drug utilization index in the observation group was lower than that in the control group，with significant difference　（P＜0.05）.Conclusion According to quinolone antibacterial drugs of irrational drug use causes implementation for pharmaceutical intervention can effectively reduce the unreasonable drug application，improve drug utilization rate.
		2016 Vol. 23 (24): 110-112 [Abstract] ( 139 ) HTML (36 KB) PDF (0 KB) ( 26 )

	113	App lication value of Levofloxacin in the patients with initial treatment of pulmonary tuberculosis
		GONG Shi
		Objective To explore the application value of Levofloxacin in the patients with initial treatment of pulmonary tuberculosis.Methods 58 patients with initial treatment of pulmonary tuberculosis in our hospital from October 2012 to March 2014 were selected and divided into the control group　（conventional anti-tuberculosis treatment group）and the observation group　（conventional treatment and Levofloxacin group）according to themethod of random number table，29 cases in each group.The sputum negative conversion rates and lesion absorption rates at the second，fourth and sixth month after the treatment，pulmonary function indexes before the treatment and at the second，fourth and sixth month after the treatmentwas compared between the two groups.Results The sputum negative conversion rates and and lesion absorption rates in the observation group at the second，fourth and sixthmonth after the treatmentwas higher than that in the control group，with significant difference　（P＜0.05）.The level of VC，MMF，MVV，FEV1.0 in the observation group at the second，fourth and sixth month after the treatmentwas better than that in the control group，with significant difference　（P＜0.05）.Conclusion The application value of Levofloxacin in the patients with initial treatment of pulmonary tuberculosis is higher，and its role for the improvement of respiratory function state is obvious.
		2016 Vol. 23 (24): 113-114转120 [Abstract] ( 148 ) HTML (35 KB) PDF (0 KB) ( 34 )

	115	Clinical analysis of Cefoperazone sodium/Sulbactam sodium（Shupushen）in the treatment of pulmonary infection in the elderly patients
		MA Hua-ping
		Objective To explore the clinical effect of Cefoperazone sodium/Sulbactam sodium（Shupushen）in the treatment of pulmonary infection in the elderly patients.Methods Clinical data of 200 cases of elderly patients with pulmonary infection in our hospital from March 2012 to January 2015 were retrospective analyzed.According to the different treatment methods，all patients were divided into the Zuoke group and the Shupushen group，100 cases in each group.The Zuoke group was given Levofloxacine hydrochloride injection　（Zuoke），the Shupushen group was given Shupushen.The total effective rate，the incidence rate of side effects of drugs and the level of IL-6，CRP，WBC and TNF-α before and after the intervention was compared between the two groups respectively.Results There was no significant difference in the total effective rate between the two groups in the treatment of pulmonary infection　（P＞0.05）.The level of IL-6，CRP，WBC and TNF-αafter the intervention in the Shupushen group was better than that in the Zuoke group，with significant difference　（P＜0.05）.The incidence rate of side effects of drugs in the Shupushen group was lower than that in the Zuoke group，with significant difference（P＜0.01）.Conclusion Clinical effect of Shupushen in the treatment of pulmonary infection in the elderly patients is exact，which can effectively improve clinical symptoms，reduce the level of inflammation of the body，and less side effects，higher safety，it isworthy of clinical promotion and application.
		2016 Vol. 23 (24): 115-117 [Abstract] ( 154 ) HTML (35 KB) PDF (0 KB) ( 8 )

	118	Efficacy analysis of domestic Urokinase intravenous thrombolysis in the treatment of 72 cases of acutem yocardial infarction in primary hospital
		HUANG Xiang-rong
		Objective To explore the effect of intravenous thrombolysis with domestic Urokinase in the treatment of acutemyocardial infarction.Methods 144 cases of acutemyocardial infarction from February 2013 to June 2014 in our hospital were selected and randomly divided into the control group and the observation group，72 cases in each group. The observation group was given domestic Urokinase intravenous thrombolytic therapy，the control group was not given thrombolysis treatment.The incidence rate of chest pain，vascular patency rate and mortality rate in the two groups was compared.Results The incidence rate of chest pain after treatment in the observation group was lower than that in the control group after treatment，with significant difference　（P＜0.01）.The incidence rate of arrhythmia in the observation group was higher than that in the control group，with significant difference（P＜0.01）.The vascular patency rate of the observation group was 75.00%，which was higher than 9.72%of the control group，with significant difference　（P＜0.01）.The mortality rate of the observation group was 5.56%，which was lower than 29.17%of the control group，with significant difference　（P＜0.01）.Conclusion Domestic Urokinase intravenous thrombolysis in the treatment of acutemyocardial infarction has significant effect，it isworthy of promotion and application in primary hospital.
		2016 Vol. 23 (24): 118-120 [Abstract] ( 132 ) HTML (37 KB) PDF (0 KB) ( 43 )

	121	Effect observation of Benazepril combining with Am lodipine in the treatment of refractory hypertension
		LIAOWen-guang
		Objective To explore the effect of Benazepril combining with Amlodipine in the treatment of refractory hypertension.Methods 120 patientswith refractory hypertension in our hospital from June 2012 to June 2016 were selected and divided into the control group and the observation group according to different therapeutic methods，60 cases in each group.The control group was only given Benazepril，the observation group was given the combination of Benazepril and Amlodipine.The level of systolic pressure and diastolic pressure，clinical effect before and after treatmentwas compared in the two groups.Results The level of systolic pressure and diastolic pressure after treatment in the two groups was lower than that before treatment，with significant difference　（P＜0.05）.The level of systolic pressure and diastolic pressure after treatment in the observation group was lower than that in the control group after treatment，with significant difference　（P＜0.05）.The total effective rate of the observation group was higher than that of the control group，with significant difference　（P＜0.05）.Conclusion Combination of Benazepril and Amlodipine can improve clinical symptoms in the treatment of refractory hypertension with a good effect，which isworthy of clinical promotion and application.
		2016 Vol. 23 (24): 121-123 [Abstract] ( 120 ) HTML (34 KB) PDF (0 KB) ( 38 )

	124	Influence of different high-dose Methotrexate on minimal residual disease of children acute lym phoblastic leukemia
		KONG Jie;ZHANG Zhen;LUO Zheng;LIN Yun-bi
		Objective To explore the influence of different high-dose Methotrexate（HD-MTX）onminimal residual disease（MRD）of children acute lymphoblastic leukemia（ALL）.Methods 110 chlidren patientswith ALL in the consolidation period of HD-MTX treatment in our hospital from January 2014 to May 2016 were selected as the study subjects，and HD-MTX was used for treatment for 459 times.All chlidren patients were divided into group A　（283 cases）and group B（176 cases）according to different HD-MTX.The blood drug concentration of 44 hours MTX and the MRD value before and after chemotherapy was compared between the two groups.Results The blood drug concentration of 44 hours MTX in group A was（0.23±0.25）μmol/L，which was lower than（0.30±0.36）μmol/L in group B，with significant difference　（P=0.016）.There was significant difference in the MRD values between before and after chemotherapy　（P= 0.009）.Conclusion With the increases of HD-MTX dosage，the average value blood drug concentration of 44 hours MTX also increases.Different HD-MTX has impact on the MRD of children patientswith ALL.
		2016 Vol. 23 (24): 124-126 [Abstract] ( 132 ) HTML (35 KB) PDF (0 KB) ( 44 )

	127	Content determination　of anhydrous theophylline　in　aminophylline bromhexine and chlorphenamine tablets by HPLC
		CHEN Yan;MENG De-gang;CHEN Cui-hong
		Objective To establish a HPLCmethod for the content determination of anhydrous theophylline in aminophylline bromhexine and chlorphenamine tablets.Methods The determination was performed on Agilent XDB-C18column （4.6mm×150mm，5μm）with themobile phase consisted ofmethanol-0.12%sodium pentanesulfonate solution（20∶80，pH was adjusted to 2.9±0.1 with acetic acid）.The flow rate was 1.0 ml/min.The detection wavelength was 254 nm.Results The method showed a good linear relationship for anhydrous theophylline within the range of 0.3202～1.2808μg，the mean recovery ratewas 101.4%with RSD of 1.3%　（n=9）.Conclusion Themethod is simple，accurate.It can be used for quality control of aminophylline bromhexine and chlorphenamine tablets.
		2016 Vol. 23 (24): 127-129 [Abstract] ( 99 ) HTML (38 KB) PDF (0 KB) ( 14 )

	130	Study on app lication of macroporous resin in separation and purification of the total flavonoids in herba Cistanche
		XU Chang-yong;YANG Kai
		Objective Tomake use of the principle of adsorption and desorption and conduct the static adsorption experiment so as to study the AB-8 macroporous adsorption resin′s adsorption and desorption of the total flavonoids in herba Cistanche.Methods The optimum separation and purification conditions were obtained through dynamic adsorption experiment and orthogonal tests.Results The concentration，flow rate and the best adsorption condition of sample solution was 1.5mg/ml，3ml/min and pH=6；80%ethanolwas eluted with the flow rate of 3 ml/min，and 12 times of the column bed volume was used as the optimal desorption conditions.Conclusion The technical process proves its stability and feasibility in separation and purification of the total flavonoids content in herba Cistanche，which elevates the postseparation-and-purification total flavonoids from 6.63%to 72.35%and is suitable for industrial production.
		2016 Vol. 23 (24): 130-134 [Abstract] ( 105 ) HTML (66 KB) PDF (0 KB) ( 22 )

	135	Clinical observation of spinal-diagnose&chiropractic-manipulation in treating palpitation due to spines disorders
		DONG Jian-jun;ZHANG Pan;ZHANGGui-feng
		Objective To study the results of spinal-diagnose&chiropractic-manipulation in treating the palpitation due to spines disorders.Methods 106 patients with palpitation due to spines disorders collected in our hospital outpatient from October 2012 to December 2015 were randomly divided into chiropractic-manipulation treatment group and acupuncture control group according to random number table，with 53 cases in each group.Patients in the chiropracticmanipulation treatment group were treated by the characteristics spinal-diagnose&chiropractic-manipulation therapy of our hospital，patients in the acupuncture control group were treated by routine acupuncture therapy.Both of two groups were treated once a day，ten days were a course of treatment.After two courses of treatment，the curative effectwas observed.Results The total effective rate in the chiropractic-manipulation treatment group was 98.11%，while 86.79%in the acupuncture control group，the difference was statistically significant（P＜0.01）in two groups.Conclusion The treatment effect of spinal-diagnose&chiropractic-manipulation therapy for palpitation due to spines disorders is significant，and it isworthy to popularize in clinic.
		2016 Vol. 23 (24): 135-138 [Abstract] ( 106 ) HTML (50 KB) PDF (0 KB) ( 31 )

	139	The clinical study of milli-fire need le therapy combining with Chinese herbs for Qi stagnation and blood stasis type of postherpetic neuralgia
		CHEN Ti-gao;XU Chuan-qin;XIANG Yong;CHEN Luo-di;ZENG Xiao-xia;XU De-gang
		Objective To observe the effects ofmilli-fire needle therapy combining with Chinese herbs on treating Qi stagnation and blood stasis type of postherpetic neuralgia（PHN）.Methods Eighty patientswith Qi stagnation and blood stasis type of PHN treated in our department from October 2015 to June 2016 were enrolled and randomly divided into treatment group and control group.Patients in the treatment group was treated with milli-fire needle therapy combining with oral herb decoction，while patients in the control group was treated with oralmecobalamin and cimetidine，plus intramuscular injection of vitamin B12，all the courses were onemonth.After onemonth of treatment，the therapeutic effect was evaluated in two groups.Results The effective rate of treatment group and control group was 95.0%and 65.0%，showing significant difference between two groups（P＜0.05）.Conclusion Milli-fire needle therapy combing with Chinese herb is a safe and effective way of treating PHN.It′s suitable for clinical popularization and application.
		2016 Vol. 23 (24): 139-141 [Abstract] ( 117 ) HTML (38 KB) PDF (0 KB) ( 32 )

	142	Clinical and pathological study on malignant phyllodes tumor and leiom yoma of breast
		NAN Nan;LIZhi-yi
		Objective To explore the clinical and pathologic features，diagnosis，differential diagonisis of the breastmalignant phyllodes tumor and leiomyoma.Methods A case of breastmalignant phyllodes tumor and leiomyoma was studied clinically，histopathologically with immunohistochemically，and the related literatures were reviewed as well.Results Themajor organizational performances of themalignant phyllodes tumor were benign epithelial components and rich fibrous stromal cells which formed leaf structure and protruded into the cavity.Immunohistochemical tumor cells in Vimentin was positive.Leiomyoma was composed of a large number of smooth muscle cells in the staggered arrangement，herringbone structure.Immunohistochemical tumor cells in SMA，Desmin and Vimentin were positive.Conclusion Breast malignant phyllodes tumor and leiomyoma are rare neoplasm，it ismore rare that happened at the same time.They all have characteristic clinical and pathological features，and wemust find the difference with other borderline ormalignant tumors.
		2016 Vol. 23 (24): 142-144转147 [Abstract] ( 109 ) HTML (40 KB) PDF (0 KB) ( 5 )

	145	Effect of C/EBP homologous protein （CHOP）on heart ischemicmyocardial damage in intermittent hypoxia
		WANG Yuan-yuan;CAO Jian;WAN Jian-hua
		Objective To investigate effect of C/EBP homologous protein　（CHOP）on heart ischemicmyocardial damage in intermittent hypoxia.Methods Fifty-four rats were randomly divided into 3 groups:sham-operated group（n=18），myocardial ischemia reperfusion group（I/R）（n=18），intermittent hypoxia+I/R group（n=18）.I/Rmodelwas established by ligating the left anterior descending coronary artery，mice were exposed to intermittent hypoxia cycles to establish the IH model，TUNEL was used to detect the cardiacmyocyte apoptosi，the expression of CHOP was analyzed by Western blot. Results The apoptosis rate of sham-operated group，the I/R group，I/R+intermittent hypoxia group was　（4.16±2.27）%，（38.68±4.58）%，（18.72±6.71）%respectively，there was significant difference between the groups（P＜0.05）.The expression of CHOP of sham-operated group，the I/R group，I/R+intermittent hypoxia group was（1.612±0.284）%，（0.946±0.372）%，（0.547±1.429）%respectively，there was significant difference between the groups（P＜0.05）.Conclusion IH is crucial for the cardioprotection against I/R，the protectivemechanism may be related to the decrease of CHOP expression.
		2016 Vol. 23 (24): 145-147 [Abstract] ( 120 ) HTML (37 KB) PDF (0 KB) ( 38 )

	148	Analysis on the results of neonatal bone alkaline phosphatase in children with 8，18，30months
		LIANGGui-jie
		Objective To analyze the detection results of bone alkaline phosphatase（NBAP）in children with 8，18，30 months.Methods NBAP of 2640 cases of 8，18，30 months Pulandian children who medicated in maternal and child health care hospital of Dalian city from May to October 2015 were detected，according to the former Ministry of Health issued the infant rickets prevention scheme for clinical screening for rickets.And NBAP test resultswere abnormal after treatment review，the change of NBAP value was observed.Results The age smaller，the higher the incidence of rickets，NBAP suspicious rate was 77.3%，rickets limit value of NBAP was equal to or larger than 250 U/L，the prevalence rate of 15.1%.The positive rate of prevention and abnormal positive rate of boys was slightly higher than that of girls，the difference was not statistically significant（χ2=1.06，P＞0.05）.The positive rate of infants and young children living in the villages and towns was significantly higher than that in the city，and the difference was statistically significant（χ2= 124.00，P＜0.01）.The effective rate of the treatment group was 76.33%，higher than 37.37%of the control group，the difference was statistically significant（χ2=32.97，P＜0.01）.Conclusion NBAP is a reliable indicator for the early diagnosis of infantile rickets，but also determine themonitoring index of treatment effect.
		2016 Vol. 23 (24): 148-150 [Abstract] ( 129 ) HTML (38 KB) PDF (0 KB) ( 35 )

	151	App lication value of serum calcitonin in the diagnosis of systemic and local bacterial infection
		HU Jian-xin;XIONG Zhi-min
		Objective To study on serum procalcitonin（PCT）detection in diagnosis of systemic and local bacterial infection.Methods 90 cases of patientswith bacterial infections in our hospital from January 2015 to January 2016 were selected（infection group），the systemic bacterial infection in 40 patients（general group），50 cases of patientswith localized bacterial infection（local group），a total of 40 cases of healthy persons（control group），the infection group were given antibiotic therapy，the serum PCT before treatment，three groups of infected group of gram positive bacteria（G+bacteria）and Gram-negative bacteria（G-bacteria）infected serum levels of serum PCT，PCT group after treatmentwere detected.Results The serum PCT of infection group was higher than that in healthy group before antibacterial before treatment respectively，the serum PCT of the general group was significantly higher than that of the local group.In the general group，the serum PCT of G+patientswas significantly higher than that of G-patients，and the difference was statistically significant（all P＜0.05）.Conclusion The serum PCT level of systemic bacterial infection has high sensitivity，and local infection is not sensitive.It can be used as an important diagnostic indicator of systemic infection.
		2016 Vol. 23 (24): 151-153 [Abstract] ( 124 ) HTML (39 KB) PDF (0 KB) ( 12 )

	154	Clinical pharmacy practice of automatic single dose tablet packing device
		SUN Jia-yue;ZUO Jing;CAO Jin-di;FAN Xiu-ying;WANG Yan;HE Xian-mei
		Objective To explore the existed problems of automatic single dose tablet packing device in the process of application in our dispensary for inpatients and put forward improved measures.Methods With a reference to the practice data of applying single dose tablet packing device in our hospital，problems including errors in drug dispensing and error of performance in packing device in the process of application were retrospectively analyzed.Results The single dose tablet packing device could increase work efficiency for both pharmacists and nurses，and improve patient′s compliance and safety，but there was error in drug dispensing during application，which should be overcome by improving quality ofmedicine，checking out and maintaining the working condition of packing device，and normalizing electronic medical order aiming at increasing the accuracy rate of drug dispensing.Conclusion Application of the single dose tablet packing device is a development tendency of informatization and automation in medical system，which provides a pharmaceutical service in a safer and more superior way.Continuous optimization of packing system and high-quality drugs for dispensing set up awider space for the application of single dose tablet packing device.
		2016 Vol. 23 (24): 154-156 [Abstract] ( 155 ) HTML (38 KB) PDF (0 KB) ( 24 )

	157	Detection and analysis of Newport e360 breathing machine before clinical application
		HAOMei-shuo
		As one of life support equipments，each parameter of breathingmachine before application should be inspected carefully.Only if each parameter is accurate，safe usage is ensured in clinical departments.From clinical usage of breathing machine in the hospital，the paper briefly introduced each detection and analysis of detected outcomes in Newport e360 breathingmachine.Targeting on the detected outcomes，a series of solutionswere put forward.Improvement of effectiveness and safety in using breathing machines is in favor of cultivating a scientific and rigorous manner of working inmedical staffwith the hope of helping other clinical users.
		2016 Vol. 23 (24): 157-159 [Abstract] ( 102 ) HTML (45 KB) PDF (0 KB) ( 37 )

	160	A case report of primary squamous cell carcinoma of ureter and literature review
		YANG Yun-jie;LIU Qi
		Objective To explore the clinical feature of primary squamous carcinoma of ureter.Methods The clinical data of 1 case of perinephric fat，ureteral broken end，renal biopsy sections withour cancer was reviewed.Patient with cancerwas sporadic and had a history of ureteral stones.Results Postoperative pathological examination showed a highly differentiated squamous cell carcinoma of the ureter，which was infiltrated into the lamina.Conclusion For patients with a long-term of chronic stimulation such as calculior inflammation，squamous cell carcinoma of ureter should be alerted.
		2016 Vol. 23 (24): 160-162 [Abstract] ( 107 ) HTML (36 KB) PDF (0 KB) ( 32 )

	163	Literature review of one sarcoma of parotid gland
		LUO Ke-qing;LAN Xiao-lin;TIAN Ke-qiang;XIAO Fu-fu;LIANG Ting;WANG Dong-mei;LI Rong;ZHANG Xiang-min
		By observation the clinical data and pathology of one sarcoma of parotid gland，the related literature of the sarcoma of parotid gland was reviewed and analyzed to explore the histogenesis and clinical treatment of sarcoma of parotid gland.The histogenesis of sarcoma of parotid gland high possibility derives from undifferentiated myoepithelial cells and diagnosismust be confirmed by postoperative pathology.Diagnosis of sarcoma of the parotid gland should be clearly defined by pathology，the preferred treatment is surgical treatment and the prognosis is poor.
		2016 Vol. 23 (24): 163-165 [Abstract] ( 114 ) HTML (41 KB) PDF (0 KB) ( 36 )

	166	Report a case of neonatal lupus erythematosus
		LILin;CHEN Li-ping;YU Man-li
		A case′s clinicalmanifestation laboratory examination and treatment was analyzed，which chief complaint is rash.Neonatal lupus erythematosus（NLE）has various clinicalmanifestations，themain diagnostic basis are skin rash and congenital heart block（CHB）.In order to avoid misdiagnosis，we should improve the awareness of neonatal lupus erythematosus.
		2016 Vol. 23 (24): 166-168 [Abstract] ( 111 ) HTML (38 KB) PDF (0 KB) ( 28 )

	169	A case of a number of ganglioside antibody positive Miller-Fisher syndrome cases report and literature review
		LAIJian-rong;DUAN Xiao-ping;XIONG You-sheng
		Objective To observe the Miller-Fisher syndrome characteristics.Methods A retrospective analysis of clinical data of 1 case of Miller-Fisher syndrome patients.Results The clinicalmanifestations of the patients in addition to the eyemyoparalysis，tendon reflex disappearing and ataxia，and drooping eyelids，anisocoria，eyes fixed on both sides，and ganglion ester were detected with multiple positive antibody.Conclusion The incidence of MFS is low，clinical is rare，and symptom complex and changeable，should be timely lumbar puncture cerebrospinal fluid routine inspection，the ganglioside antibody detection and emg can be confirmed as soon as possible.
		2016 Vol. 23 (24): 169-171 [Abstract] ( 140 ) HTML (32 KB) PDF (0 KB) ( 28 )

	172	Influence of early nursing intervention on blood glucose and blood pressure in menopausalwomen
		HUANG Liang
		Objective To explore the effect of early nursing intervention on blood glucose and blood pressure in menopausal women.Methods From January to December in 2014，200 menopausal women visited our hospitalwere selected as observation object and evenly divided into observation group and control group in random.In the observation group，early nursing intervention was provided，while in the control group，conventional nursing was adopted.The observing period lasted one year.The awareness rate of health knowledge，blood glucose，blood pressure，and score of menopausal symptoms before and after intervention were compared between the two groups.Results Before intervention，there was no statistical difference in awareness rate of health knowledge，blood glucose，blood pressure，or score of menopausal symptoms between observation group and control group（P＞0.05）.After intervention，these parameters in observation group was better than that of control group respectively，with statistical differences（P＜0.05）.Conclusion Early nursing intervention plays a remarkable effect on blood glucose and blood pressure inmenopausalwomen，and can improve awareness rate of health knowledge，standardize health behavior，alleviate menopausal symptoms，and improve blood glucose and blood pressure，which isworthy of promotion and application.
		2016 Vol. 23 (24): 172-174 [Abstract] ( 111 ) HTML (37 KB) PDF (0 KB) ( 5 )

	175	Clinical nursing study of oral administration of yogurt with sault to improve the thirst in early stage of burn shock in children
		LIUQiao-zhen;YE Xin-ying;LAIXiao-wen
		Objective To explore the clinical nursing of the treatment of burn shock with hydrochloric acid in the early stage of burn shock in children.Methods 120 cases of burn patients admitted to our department from January 2015 to March 2016 were randomly divided into two groups:experimental group（n=60）and control group（n=60）.The former were treated with yogurtwith sault and the latter were given burn drink or saline.Drinking times and volume of water，duration used to improve the thirst and correct blood volume between two groups were analyzed.Results The experimental group adhere to the oralwas significantly better than that of the control group，the difference was statistically significant （P＜0.05）；thirst improvement score in the experimental group was better than that of the control group，the blood volume to correct time was shorter than that of the control group，the difference was statistically significant（P＜0.05）.Conclusion Oraladministration ofyogurtwith saultcan be used atburn shock early stage to improve effectively hypovolume and thirst，which is the foundation to puncture successfully，can reduce the children′pain and improve nursingwork efficiency.
		2016 Vol. 23 (24): 175-177转180 [Abstract] ( 132 ) HTML (43 KB) PDF (0 KB) ( 31 )

	178	The effect of preoperative interview with self-made cartoon pictures on anxiety of preschool children undergoing laparoscopic surgery
		XU Hui-ping;LIYun-zuan;LIU Si-si
		Objective To investigate the effect of preoperative interview with self-made cartoon pictures on anxiety of preschool children undergoing laparoscopic surgery.Methods 100 cases of preschool children in maternal and child health care hospital of Foshan city for elective laparoscopic surgery from January to December 2015 were selected as the research object.They were divided into the cartoon group（study group）and the routine visit group（control group）by using themethod of random number table.The state anxiety of children′preoperative visit（T1），enter the roominduction of anesthesia（T2），during induction of anesthesia（T3）ofwas assessed bymodified Yale peri operative anxiety scale（MYPAS）.The heart rate and blood pressureweremeasured at T1and T3in children.Results At T1，the heart rate and systolic blood pressure of the two groupswas compared respectively，the difference was not statistically significant（P＞0.05）；at the T3，the heart rate and systolic blood pressure of the two groupswas compared respectively，the difference was statistically significant（P＜0.05）.At T1，the MYPASanxiety score of the two groupswas compared，the difference was not statistically significant（P＞0.05）；at T2，T3，the MYPAS anxiety score of the two groups was compared，the difference was statistically significant（P＜0.05）.Conclusion Themethod of using cartoon pictures before operation can reduce the anxiety of the patients before operation.
		2016 Vol. 23 (24): 178-180 [Abstract] ( 135 ) HTML (36 KB) PDF (0 KB) ( 21 )

	181	App lication value analysis of continuous nursing intervention in perinatal period of pregnancy with diabetes
		LIU Feng-qin
		Objective To explore the application value of continuous nursing intervention in perinatal period of pregnancy with diabetes.Methods 68 pregnancy with diabetes，met the research standards，from February 2014 to January 2016 of our hospital were selected.Patients were divided into study group and control group according to their admission order，and each group was 34 cases.Patients in control group were used routine nursing intervention，and patients in study group were used continuous nursing intervention on the basis of routine nursing.The changes of blood sugar level before and after nursing，changes of anxious and depression score and nursing satisfaction degree in two groups were compared.Results Before nursing，the difference of fasting blood glucose，postprandial 2 h blood glucose，glycosylated hemoglobin level，anxious and depression score between two groups had no statistical significance（P＞0.05）.After nursing，the index in study group was obvious better than that of control group，and the difference was statistical significance（P＜0.05）.The nursing satisfaction in study group and control group were respectively 94.12%and 70.58%，and the difference was statistical significance（P＜0.05）.Conclusion Continuous nursing intervention in perinatal period of pregnancy with diabetes has great value，which can improve the blood glucose level and anxious and depression status of patients effectively，enhance nursing satisfaction and with promotion value.
		2016 Vol. 23 (24): 181-183 [Abstract] ( 127 ) HTML (39 KB) PDF (0 KB) ( 21 )

	184	Effect of bridge-style movement on lumbago and backache in senile osteoporosis
		HUANG Li-zhen;CHEN Jian;HE Jian-quan
		Objective To investigate the effects of bridge-style movement on lumbago and backache in senile osteoporosis.Methods 63 patients with primary osteoporosis in our hospital from January 2015 to January 2016 were randomly divided into observation group 1，observation group 2 and control group.All the patients of three groups received drug therapy，health education and routine nursing care.Observation group 1 and observation group 2 received different intensity of bridge-stylemovement in order to exercise back muscle and relieve pain.The intervention effect was observed in each group.Results Lumbago and backache symptoms in observation group 1 and group 2 were reduced gradually by bridge type movement in 4 weeks respectively.Visual analogue scale score of observation group 1 and group 2 was significantly lower than that of the control group respectively（P＜0.05，P＜0.01）；The effective rate of observation group 2 was higher than that of observation group 1（P＜0.05）.Conclusion Increasing the time，strength and endurance of bridge-style movement therapy can ease lumbago and backache of senile osteoporosis significantly.The bridge-stylemovement can improve the quality of life in senile osteoporosis.
		2016 Vol. 23 (24): 184-187 [Abstract] ( 109 ) HTML (44 KB) PDF (0 KB) ( 31 )

	188	Influence of Orem self-caremode on treatment com p liance and quality of life of patientswith rectal cancer after operation
		TAO Run-ying;XIE Li-yun
		Objective To investigate the effect of Orem self-caremode on the treatment compliance and quality of life of patients with rectal cancer after operation.Methods 80 cases of rectal cancer treated by Miles in our hospital from January to June 2016 were divided into control group（40 cases）and observation group（40 cases）according to the random number tablemethod.The control group was given routine nursing，the observation group on the basis of conventional nursing，was given Orem self-care mode throughout the whole process of routine nursing.Results The scores of SAS and SDS in two groupswas significantly decreased respectively，but the observation group decreased more significantly，with statistical difference（P＜0.05）.The score of SF-36 scale in the observation group was significantly higher than that in control group respectively，with statistical difference（P＜0.05）.In the observation group，length of hospital stay was significantly shorter than that of the control group，comfort and compliance of nursing score was significantly higher in control group，with statistical difference（P＜0.05）.Conclusion Orem self-caremode canmeet the needs of patients，ensure that patients get high quality of care needs，training patientswith good self-care ability，has a very important clinical application value.
		2016 Vol. 23 (24): 188-190 [Abstract] ( 101 ) HTML (39 KB) PDF (0 KB) ( 29 )

	191	Effect of nursingmidwife antepartum education on labor
		WANG Xiao-ping
		Objective To study the effect of nursing midwife antepartum education on labor.Methods 300 primiparas coming from our hospital between April 2013 to April 2015 were randomly divided into observation group and the control group，each group 150 cases.The observation group received nursing midwife antepartum education before delivery，the control group received routine nursing.Compared the deliverymode，labor and effectivematched rate of two groups.Results The spontaneous vaginal delivery rate in observation group was 93.33%significantly higher than that was 46.67%in the control group，the labor in observation group was significantly lower than that in control group（P＜0.01），the effectivematched rate in observation group was 94.00%significantly higher than thatwas 79.33%in control group，the differenceswere statistically significant（χ2=13.962，P＜0.01），the average amount of bleeding in the observation group was　（159.04±7.19）ml，significantly less than that was（234.38±8.81）ml in control group，the differences were statistically significant（t=81.143，P＜0.01）.Conclusion Nursingmidwife antepartum education can effectively improve the early maternal natural childbirth confidence and improve the spontaneous vaginal delivery rate，shorten the labor，decrease postpartum hemorrhage.It has important clinical value.
		2016 Vol. 23 (24): 191-193 [Abstract] ( 99 ) HTML (38 KB) PDF (0 KB) ( 32 )

	194	Application analysis of com prehensive intensive nurse model in patients with acute coronary artery syndrome undergoing PCI operation
		OU Hui-zhen;HEQing-jun;PANG Jian-ping
		Objective To explore the application effect of comprehensive intensive nursingmodel in patientswith acute coronary artery syndrome undergoing percutaneous coronary intervention　（PCI）operation，and to provide reference for nursing of patients with acute coronary artery syndrome by PCI.Methods 60 cases of acute coronary artery syndrome patients from January to December in 2015 in our hospital were selected and randomly divided into the experimental group and the control group，30 cases in each group.All patients were taken PCI surgery.The control group was given routine nursing，the experimental group was given comprehensive intensive nursing.The incidence rate of complications，length of hospital stay，total satisfaction rate of nursing and sleep quality score was compared between the two groups. Results The incidence rate of complications in the experimental group was 3.33%，which was lower than 33.33%in the control group，with significant difference　（P＜0.01）.The total satisfaction rate of nursing in the experimental group was 96.67%，which was higher than 66.67%in the control group，with significant difference　（P＜0.01）.The length of hospital stay in the experimental group was shorter than that in the control group，with significant difference　（P＜0.01）.The sleep quality score of the experimental group was lower than that of the control group，with significant difference　（P＜0.01）. Conclusion The comprehensive intensive nursing of patientswith acute coronary artery syndrome during the perioperative period of PCI has a positive significance，which can effectively reduce the complications of patients，shorten the length of hospital stay，improve the sleep quality，and earn higher nursing recognition，it is worthy of clinical promotion and application.
		2016 Vol. 23 (24): 194-196 [Abstract] ( 110 ) HTML (42 KB) PDF (0 KB) ( 30 )

Copyright © Editorial Board of 中国当代医药
Supported by:Beijing Magtech