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2018 Vol. 25, No. 14
Published: 2018-05-18
 
 
4 Study on anti-apoptosis effect and mechanism of dihydromyrcetin on focal cerebral ischemia-reperfusion injury in mice
GAN Lu；DENG Zhi-jing；WANG Xian-zhe；SHU Qi；LIANG Cong；GUO Zhe； HE Ping
Objective To study the anti-apoptosis effect of dihydromyricetin (DMY)on acute focal cerebral ischemia/reperfusion(I/R)injury in mice.Methods Male Kunming mice were randomly divided into sham group,I/R group and DMY group (500 mg/kg).Mice model of I/R injury was established by middle cerebral artery occlusion (MCAO)using modified thread method.Daily intragastric administration of DMY was carried out 10 days before the surgery,and 1 hour before ischemia and 12 hours after reperfusion.The brain tissues of the mice were harvested after ischemia for 3 hours and reperfusion for 24 hours.Myocyte apoptosis in the cerebral I/R brain was detected with in situ terminal deoxynucleotidyl transferase(TdT)-mediated dUTP nick-end labeling(TUNEL staining).The protein and mRNA expression of Bax and Bcl-2 were detected by immunohistochemistry assay and real-time quantitative PCR (RT-qPCR)respectively.Results Compared with sham group,apaotosis index was significantly higher,protein and mRNA expressions of Bcl-2 were lower than those of Bax were higher in I/R model group(all P＜0.01).Compared with I/R model group,in DMY group,apoptosis index decreased significantly,the expressions of Bcl-2 were higher,those of Bax were lower(all P＜0.01).Conclusion DMY can reduce the myocyte apoptosis induced by focal I/R injury,its anti-apoptotic mechanism might be related to regulating the expressionof Bax and Bcl-2.
2018 Vol. 25 (14): 4-8 [Abstract] ( 195 ) HTML (48 KB)  PDF  (0 KB)  ( 33 )
9 Protective effect of Curcumin on the renal interstitial fibrosis of rat by Cyclosporin A
WANG Run-xiu；WANG Guo-ping；CAO Chun-yu；LI Wei-song；XIE Fu-hua
Objective To investigate the protective effects of Curcumin(Cur)on the renal interstitial fibrosis induced by CsA and reveal the underlying molecular mechanisms.Methods 18 SD rats were randomly divided into control group(Ctrl group,n=6),CsA group (n=6)and group CsA+Cur group (n=6)and the above-mentioned groups was treated with olive oil,CsA and CsA combined with Cur respectively.The effect of Cur on renal interstitial fibrosis in rats were observed by measuring body weight,blood urea nitrogen and creatinine,and histopathological examination.The level of ROS was detected by detecting SOD activity and MDA content in rat kidney tissue.The expression of transforming growth factor beta(TGF-β)in renal tissue was detected by molecular biology.Results Compared with ctrl group,weights of rats in CsA group decreased obviously (P＜0.05),and the level of blood urea nitrogen and creatinine increased significantly (P＜0.05),and the expression of TGF-β increased significantly(P＜0.05).The level of ROS increased,and the pathological findings were mild interstitial fibrosis.However,giving Cur at the same time could alleviate the above symptoms to some extent.Conclusion Cur has a some protective effect on the renal interstitial fibrosis which induced by CsA,and its molecular mechanism may be down-regulating the expression of TGF-β and the level of ROS.
2018 Vol. 25 (14): 9-12 [Abstract] ( 178 ) HTML (42 KB)  PDF  (0 KB)  ( 23 )
13 Effect of receptor activator of nuclear factor-κB ligand on the secretion of vascular endothelial cell growth factor from human glomerular podocytes induced by angiotensinⅡ
QI Yue；ZHU Tao；QIN Zhi-cheng
Objective To investigate the effect of receptor activator of nuclear factor-κB ligand (RANKL)on the secretion of vascular endothelial growth factor(VEGF)induced by angiotensinⅡ (AngⅡ)in human renal podocytes,and to explore whether AngⅡaffecting VEGF expression in podocytes through RANK/RANKL signaling pathway.Methods The human renal podocytes differentiated into dendrites were selected as research subjects.They were dealt with AngⅡin different concentrations (0,1,10,100 nmol/L).Real-time fluorescence quantitative PCR was performed at different time(0,6,12,24 h)to detect the changes in mRNA expression of the genes VEGF,RANK,and RANKL.Then podocytes were stimulated with different doses of RANKL and 100 nmol/LM AngⅡfor 24 h.The expression of VEGF mRNA was detected by RT-PCR and the apoptosis rate of podocytes was detected by flow cytometry.Results AngⅡinduced podocyte expression of VEGF,RANK,and RANKL in a dose-and time-dependent manner(P＜0.05),while excess RANKL showed dose-dependent blockade of VEGF expression increasing (P＜0.05).Compared with the control group,AngⅡsignificantly induced podocyte apoptosis(P＜0.05),while RANKL inhibited podocyte apoptosis induced by AngⅡ (P＜0.05).Conclusion AngⅡmay affect podocyte expression of VEGF through RANK/RANKL signaling pathway.RANKL inhibits the apoptosis of the podocytes induced by AngⅡby regulating the expression of VEGF gene through feedback regulation and protects the kidneys.
2018 Vol. 25 (14): 13-16转20 [Abstract] ( 148 ) HTML (41 KB)  PDF  (0 KB)  ( 29 )
17 Influence of Dezocine on emergence agitation of surgical anesthesiain in children given laparoscopic surgery
LIU Dong-zhi；ZHAO Zhi-bin
Objective To explore the influence of Dezocine on emergence agitation of surgical anesthesiain in children given laparoscopic surgery.Methods 60 children scheduled for laparoscopic high ligation of hernia sac treated in the First People′s Hospital of Lianyungang from April 2016 to November 2017 were selected and they were randomly divided into the Dezocine group (n=30)and control group (n=30).15 min before the end of operation,Dezocine group was given 0.1 mg/kg Dezocine,while the control group was given the same volume of normal saline.The operation time,extubation time and modified Aldrete score when entered into the post-anesthesia care unit(PACU)and PACU retention time were observed and recorded.Mean arterial pressure(MAP)and heart rate(HR)were recorded at the time before anesthesia(T0),drug withdrawal(T1),extubation(T2)and 5 min after extubation(T3).At the same time,pediatric anesthesia emergence delirium(PAED)score,modified children′s hospital of Eastern Ontario Pain Scale(m-CHEOPS)score and the incidence of adverse reactions were recorded.Results PAED score and m-CHEOPS score in the Dezocine group were lower than those in the control group(P＜0.001).There were no significant difference in the extubation time,the modified Aldrete score or PACU retention time between the two groups(P＞0.05).MAP and HR of the Dezocine group were lower than those of the control group at T1and T2(P＜0.05).The HR of Dezocine group was slower than that of the control group at T2and T3(P＜0.05).Adverse reactions were not found in the two groups.Conclusion Intravenous infusion of 0.1 mg/kg Dezocine before the end of operation in children′s laparoscopic high ligation of hernia sac can prevent the incidence of emergence agitation after general anesthesia but don′t prolong the postoperative recovery and extubation time in children.The hemodynamics was stable and adverse reactions were not observed in children.
2018 Vol. 25 (14): 17-20 [Abstract] ( 172 ) HTML (37 KB)  PDF  (0 KB)  ( 30 )
21 Clinical effect analysis of Valsartan combined with Amlodipine in treatment of patients with renal hypertension
NI Li
Objective To observe the clinical effect of Valsartan combined with Amlodipine in the treatment of renal hypertension.Methods All of 86 patients with chronic kidney disease complicated with renal hypertension treated in our hospital from January 2014 to June 2017 were selected,the patients were divided into two groups by randomly number table method,and each group had 43 cases.The observation group was treated by Valsartan combined with Amlodipine,the control group was treated by only Valsartan.The two groups were treated 4 courses.The blood pressure,changes in renal function indicators,medication safety of the two groups were observed.Results the total effective rate of the observation group was higher than that of the control group,and there was a statistical significance (P＜0.05).After treatment,the level of SBP and DBP in both groups were lower than those in the control group and the level of SBP and DBP in the observation group were lower than those in the control group(P＜0.05).The level of SCr,BUN and 24 h urine protein in the two groups were lower than those before treatment and the glomerular filtration rate (GFR)level of the observation group was higher than that before treatment,and the differences were statistically significant(P＜0.05).The level of SCr,BUN and 24 h urine protein in the observation group were lower than those of the control group,and the level of GFR was higher than that of the control group (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The effect of Valsartan combined with Amlodipine in treatment of patients with renal hypertension is exact,it has significant effect in lowering blood pressure and protecting of renal function in patients,and the drugs were highly safety,It can be vigorously promoted in clinic.
2018 Vol. 25 (14): 21-24 [Abstract] ( 201 ) HTML (38 KB)  PDF  (0 KB)  ( 23 )
25 Advances in clinical application of Dexmedetomidine in children
LI Ya-qian；FAN Jun-bai；CHEN Li
Dexmedetomidine (Dex)has been recognized by most physicians since its application in adults.Pediatric anesthesia has many particularities,preoperative anxiety,crying,postoperative pain,delirium,etc.which not only increase the risk of surgery and anesthesia,but also easy to cause psychological and physical trauma in children.So anesthesia medication of pediatric has been exploring and developing.In view of the advantages of Dex in clinical,domestic and foreign medical workers use it in pediatric treatments and researches.This review is aimed to discuss the progress of its application in pediatric filed from four aspects：pharmacokinetics and pharmacokinetics,pediatric physiology and clinical application.
2018 Vol. 25 (14): 25-28 [Abstract] ( 176 ) HTML (41 KB)  PDF  (0 KB)  ( 33 )
29 Advances of diagnostic value of different imaging methods in acute stage of cerebral infarction
HONG Jing-jing；BAO Quan；LIU Xin-liang；LI Hong-yi；ZHANG He-Lin；XING Jian
Cerebral infarction has a very high rate of disability and mortality,so early diagnosis and treatment of acute cerebral infarction is of great significance.With the development of various imaging technologies,the means of evaluating the condition of patients with acute cerebral infarction are increasing.This paper analyzes the imaging methods used for diagnosis of cerebral infarction in recent years,so as to explore the diagnostic value of different imaging methods for acute phase of cerebral infarction.
2018 Vol. 25 (14): 29-31 [Abstract] ( 177 ) HTML (35 KB)  PDF  (0 KB)  ( 28 )
32 Influence of Sandplay on children′s social phobia and self-awareness
LIN Dong-mei
Objective To explore the influence of Sandplay on children′s social phobia and self-awareness.Methods From October 2015 to October 2017,78 cases of social phobia children admitted to our hospital were selected as the subject,and treated with sandplay for 2 months.The clinical efficacy,self-consciousness and social adaptability of children before and after treatment were compared and analyzed.Results The CGI-GI after treatment was significantly lower than that before treatment,and CGI-EI was significantly higher than that before treatment,the difference was statistically significant(P＜0.05).Children′s self-consciousness,such as behavior,intelligence and school,physical appearance,anxiety,group,happiness and satisfaction were significantly higher than those before treatment,the differences were statistically significant(P＜0.05).After treatment,the ability of independent living,exercise,communication,function and self management were significantly higher than those before treatment,the difference was statistically significant(P＜0.05).Conclusion Sandplay therapy for children with social phobia is effective in our hospital,significantly improves the selfconsciousness and social adaptability of children,which is worthy of wide application in clinical practice.
2018 Vol. 25 (14): 32-34 [Abstract] ( 162 ) HTML (31 KB)  PDF  (0 KB)  ( 37 )
35 Effect of laparoscopic transabdominal preperitoneal prosthetic on inguinal hernia
PENG Xiao-fei；CHEN Xiang ；WEN Wei-zhong
Objective To investigate the effect of laparoscopic transabdominal preperitoneal prosthetic (TAPP)on inguinal hernia.Methods From January 2016 to October 2017,100 patients with inguinal hernia treated in our hospital were selected as the subjects,and grouped according to different surgical methods.The control group (20 cases)were treated with traditional operation.TAPP group were treated with TAPP surgery,and TEP group were treated with TEP surgery.The operative time,postoperative autonomic activity time,postoperative observation time,postoperative pain at the wound site,intraoperative amount of bleeding,and the total incidence of scrotal edema,infection,and urinary retention were compared among the three groups.Results There was no significant difference in the operation time,postoperative autonomic activity time,postoperative observation time,postoperative pain at the wound site,or intraoperative amount of bleeding between TAPP and TEP groups(P＞0.05).The total incidence of scrotal edema,infection,and urinary retention were not displayed significant difference in the TAPP and TEP groups(P＞0.05).However,the above indicators in the TAPP and TEP groups were all better than those in the control group,the difference was statistically significant(P＜0.05).Conclusion The clinical application of laparoscopic TAPP obtains a definite effect at advantages of shorter operation time,smaller trauma compared with open surgery,reduce intraoperative bleeding and complications after surgery,and promote the postoperative recovery,which is tantamount to TEP surgery in efficacy.
2018 Vol. 25 (14): 35-37 [Abstract] ( 181 ) HTML (30 KB)  PDF  (0 KB)  ( 29 )
38 Application of citrate anticoagulation in hemodialysis patients with highrisk hemorrhage
PANG Juan
Objective To explore the clinical effect of citrate anticoagulation in hemodialysis patients with high-risk hemorrhage.Methods From October to December in 2017,80 maintenance hemodialysis(HD)patients complicated with hemorrhage bleeding tendency treated in our hospital were selected as the subject,and randomly divided into two groups,40 cases each group.The control group took the heparin-free hemodialysis.The observation group took the 4%citrate anticoagulation.The coagulation condition and biochemical indicators as well as the index of Kt/V,URR,APTT and actual ultrafiltration capacity were evaluated.Results The hemodialysis in idalyzer in the observation group was significantly better than that in the control group,the difference was statistically significant(P＜0.05).After HD,the index of BUN and SCr in the observation group were even lower than that in the control group,the difference was statistically significant(P＜0.05).Before and after HD,the value of PH,Ca2+and K+for two groups were not significantly different(P＞0.05).The value of HCO3-in the observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).The index of KT/V and URR for two groups were not significantly different(P＞0.05).The index of APTT in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The actual ultrafiltration capacity in the observation group was significantly higher than,it has the value of promotion control group,the difference was statistically significant(P＜0.05).Conclusion For HD patients with high-risk hemorrhage,the citrate anticoagulation can improve the clinical safety and effect.In addition,the hemodialysis effect is not affected,it has the value of promotion.
2018 Vol. 25 (14): 38-40转44 [Abstract] ( 196 ) HTML (35 KB)  PDF  (0 KB)  ( 31 )
41 Effect of Prunella vulgaris Decoction combined with Nifedipine in the treatment of primary hypertension
LIN Yuan-yuan ；XIONG Yi-tao
Objective To investigate the effect of Prunella vulgaris Decoction combined with Nifedipine in the treatment of primary hypertension.Methods From March 2011 to September 2016,90 patients with primary hypertension treated in our hospital were selected as the subjects,and divided into the observation group and the control group randomly,45 cases in each group.The control group was treated with Nifedipine 20 mg each time,1 times in the morning and evening.The observation group was treated with mixed Decoction of Prunella vulgaris 200 ml,1 times in the morning and evening on the basis of the treatment of the control group,and treatment continued for 120 days.The blood pressure and the pulse pressure before and after treatment in patients were detected.The nitric oxide (NO)and endothelin-1(ET-1)were detected with radioimmunoassay.The content of vascular angiotensinⅡ (AngⅡ),norepinephrine epinephrine(NE)and soluble vascular cell adhesion molecule 1(sVCAM-1)were detected with ELISA.Results The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).After the treatment,the content of NO in the two groups increased significantly (P＜0.05).The blood pressure,pulse pressure,ET-1,AngⅡ,sVCAM-1 and NE after the treatment were lower than before treatment,the difference was statistically significant(P＜0.05).After the treatment,the content of NO in the observation group was higher than that in the control group (P＜0.05).The levels of blood pressure,pulse pressure,ET-1,AngⅡ,sVCAM-1 and NE in the observation group were significantly lower than those in the control group(P＜0.05).Conclusion Prunella vulgaris Decoction combined with Nifedipine can significantly reduce the blood pressure and pulse pressure in patients with primary hypertension,effectively improve the vascular function of patients,and can achieve better therapeutic effect.
2018 Vol. 25 (14): 41-44 [Abstract] ( 176 ) HTML (38 KB)  PDF  (0 KB)  ( 38 )
45 Efficacy of high-frequency electrocoagulation on the removal of gastric polyps under painless gastroscope
WEN Zhi-hui
Objective To observe and analyze the clinical effect of high-frequency electrocoagulation on the removal of gastric polyps under painless gastroscope.Methods A total of 110 patients performed resection of gastric polyps treated in our hospital from August 2015 to March 2017 were selected as the subjects,and divided into conventional group and painless grou according to different treatment methods,55 cases in each group.In the conventional group,clip during biopsy was used,while in the painless group,high-frequency electrocoagulation under painless gastroscope was adopted.The clinical therapeutic effect and incidence of complications were compared between the two groups.ResultsThe clinical effectiveness rate in the painless group was higher than that in the conventional group,the difference was statistically significant(P＜0.05).The hospital stay in the painless group was shorter than that in the control group,the difference was statistically significant(P＜0.05).The incidence of clinical complications in the painless group was lower than that in the conventional group,the difference was statistically significant(P＜0.05).Conclusion For patients with gastric polyp,high-frequency electrocoagulation resection under painless endoscope can obtain a remarkable therapeutic effect in a low incidence of complications,which is worthy of clinical promotion and application.
2018 Vol. 25 (14): 45-47 [Abstract] ( 170 ) HTML (30 KB)  PDF  (0 KB)  ( 24 )
48 Clinical effect of posterior pedicle screw placement in the treatment of patients with senile spinal degenerative lumbar spinal stenosis
WANG Zhi-qian；ZHAO An-ju
Objective To study the effect of posterior pedicle screw placement on pain digit score (NRS score)and disability index score (ODI score)in elderly patients with spinal degenerative lumbar spinal stenosis.Methods From July 2014 to July 2016,78 cases of senile spinal degenerative lumbar spinal stenosis treated in our hospital were selected as the research subjects.According to the treatment of the patients,they were divided into the control group (38 cases)and the observation group (40 cases).Patients in the control group were treated with conservative treatment,and patients in the observation group were treated with posterior pedicle screw placement.The therapeutic effects of the two groups were compared.Results The curative effect of the observation group was 92.86%,which was significantly higher than the control group of 71.05%,the difference was statistically significant(P＜0.05).The NRS and ODI scores of the two groups were not significant before the treatment（P＞0.05）.After one month of treatment,the NRS score and ODI score of the patients in the observation group were significantly lower than those in the control group (P＜0.05).Conclusion Posterior pedicle screw placement prosthesis for elderly patients with spinal degenerative lumbar spinal stenosis disease treatment effect is better,which can effectively reduce the pain of patients,improve the lumbar vertebral function obstacle,with good safety,high clinical application value.
2018 Vol. 25 (14): 48-50 [Abstract] ( 156 ) HTML (33 KB)  PDF  (0 KB)  ( 33 )
51 Clinical effect of procedurefor prolapse and hemorrhoids combined with hemorrhoids ligation in the treatment of haemorrhagic severe hemorrhoids
CHEN Xing-yi；LIAO Ming ；LIANG Jia-ji；PENG Xiao-chun
Objective To explore the clinical effect of procedurefor prolapse and hemorrhoids (PPH)combined with hemorrhoids ligation in the treatment of haemorrhagic severe hemorrhoids.Methods From June 2015 to December 2017,100 patients with haemorrhagic severe hemorrhoids treated in our hospital were selected as the subject,and divided into the study group and the control group by radom table method,with 50 cases in each group.The patients in the control group were treated with PPH alone,and the patients in the study group were treated with PPH combined with hemorrhoid nuclear suture.The time of operation,the amount of blood lost during the operation,the time of hospitalization after operation,the pain score and the bleeding after operation were compared between the two groups.Results The operative time in the study group was longer than that in the control group,and the amount of intraoperative bleeding in the study group was larger than that in the control group,the differences were statistically significant(P＜0.05).The incidence of postoperative hemorrhage in the study group was 0%,which was significantly less than that in the control group (22%).The cure rate in the study group(90%)was significantly higher than that in the control group(72%),the differences were statistically significant(P＜0.05).The incidence of anal stricture and anal incontinence in the study group were 0.0%,which was significantly lower than that in the control group for 20.0%and 18.0%)(P＜0.05).Conclusion The effect of PPH combined with hemorrhoid nuclear ligation is better than that of the PPH alone,which should be promoted and extended.
2018 Vol. 25 (14): 51-53 [Abstract] ( 164 ) HTML (32 KB)  PDF  (0 KB)  ( 31 )
54 Management effect of mHealth on diabetics treated with Insulin
QIAN Cai-feng ；QIN Xiao-dong； LIANG Zhuo-lin； LI Min-ji
Objective To explore the management effect of mHealth in diabetic patients treated with Insulin.Methods A total of 182 patients with diabetes mellitus(DM)treated with Insulin from department of endocrinology in our hospital from April 2016 to July 2017 were selected as subjects.They were randomly divided into treatment group and control group according to the parity of treatment order,with 91 cases in each group.In the treatment group,Kangsai mobile disease management platform was used.To be specific,the APP was downloaded and installed in the mobile terminal of the patient or family.The personal file was established,the patient′s therapeutic regimen was recorded and blood glucose was monitored.Dynamic abnormality alert was implemented to prompt the patient to adjust the insulin dosage in time and guide the health education at any time.In the control group,traditional method of medical treatment was used,and follow-up visit was carried out in general out-patient clinics.After 3 months,the frequency of blood glucose monitoring,the frequency of insulin dosage adjustment,the incidence of hypoglycemia,and the proportion of return visits were compared between the two groups.The rate of blood glucose reaching the standard and changes of glycosylated hemoglobin levels before and after treatment were compared.Results In the treatment group,the proportions of blood glucose monitoring over 3 times/d,dosage of Insulin adjustment frequency over once a week and return visits were significantly higher than those in the control group,and the incidence of hypoglycemia was much lower than that in the control group,the differences were statistically significant(P＜0.05).Compared with the control group,the fasting blood glucose,2 h-postprandial blood glucose,and glycosylated hemoglobin were significantly lower in the treatment group than those in the control group after 3-month treatment,the differences were statistically significant(P＜0.05).Conclusion mHealth can effectively improve physician′s management ability to use Insulin to treat DM patients and remarkably ameliorate their blood glucose levels.
2018 Vol. 25 (14): 54-56 [Abstract] ( 161 ) HTML (34 KB)  PDF  (0 KB)  ( 24 )
57 Analysis of plasma homocysteine level and related factors in patients with type 2 diabetes
LIU Xiang-ru；LI Yue；YANG Bin；FENG Yao-ran；LIANG Yong-qian
Objective To investigate the level of plasma homocysteine(Hcy)and its related factors in patients with type 2 diabetes.Methods A total of 150 patients with type 2 diabetes treated in our hospital from August 2016 to October 2017 were selected as type 2 diabetes group,and 60 healthy persons underwent physical examination in the same period were selected as the control group.The patients in type 2 diabetes group were divided into two groups according to whether Hcy was greater than 15 μmol/L,for the high Hcy group(n=62,Hcy＞15 μmol/L)and the normal Hcy group(n=88,Hcy≤15 μmol/L).The difference of Hcy,body measurement,plasma glucose,insulin,serum creatinine,blood lipid and uric acid were compared between the two groups.The influencing factors of plasma Hcy level in patients with type 2 diabetes were analyzed by multivariate Logistic regression analysis.Results The BMI,uric acid,Hcy,FPG,2 h PG,HOMAIR and creatinine in type 2 diabetes group were higher than those in the control group,the differences were statistically significant(P＜0.05).The male proportion,age,uric acid,HOMA-IR and creatinine levels of the patients in the high Hcy group were significantly higher than those in the normal Hcy group,and the differences were statistically significant(P＜0.05).Logistic regression analysis showed that in patients with type 2 diabetes,male,blood uric acid and HOMA-IR were risk factors for high Hcy hyperlipidemia(P＜0.05).Conclusion Plasma Hcy level in patients with type 2 diabetes is significantly higher than healthy person.Male,blood uric acid and insulin resistance are risk factors for high Hcy hyperlipidemia in patients with type 2 diabetes.
2018 Vol. 25 (14): 57-59 [Abstract] ( 187 ) HTML (35 KB)  PDF  (0 KB)  ( 29 )
60 The value of high-risk HPV，P16 and Ki-67 detection in early screening of cervical cancer
LI Ke-hong；LAI Jun-ling；ZHANG Yuan-ping；ZHANG Ying-jie；WEN Da-xiong
Objective To explore the value of high-risk HPV,P16 and Ki-67 detection in early screening of cervical cancer.Methods From January 2015 to December 2017,30 cases of normal cervical tissue and the expression of P16 and Ki-67 in 75 cases of cervical intraepithelial neoplasia(CIN)were detected by immunohistochemistry in our hospital.The high-risk HPV infection was detected by polymerase chain reaction (PCR).Results The positivity rates of P16(77.80%)and Ki-67(65.80%)and In the CINⅠ,higher than those in normal cervical tissue accounting for 0.00%.The differences were statistically significant(P＜0.05).The positivity rates of P16(100.0%)and Ki-67(94.70%)in CINⅡ-Ⅲwas higher than those of CINⅠ (P＜0.05).High-risk HPV infection rates in normal cervical tissues,CINⅠ,and CIN Ⅱ-Ⅲwas 6.70%,66.70%,84.60%and 90.30%respectively,and the infection in the precancerous lesions the uterine cervix was significantly higher than that in the control group,the differences were statistically significant(P＜0.05).Conclusion High-risk HPV infection,P16,and Ki-67 are associated with the occurrence and development of precancerous lesions of the uterine cervix.Use in combination can be considered as an auxiliary method for the diagnosis of CIN grading and has a good application value.
2018 Vol. 25 (14): 60-62 [Abstract] ( 191 ) HTML (32 KB)  PDF  (0 KB)  ( 33 )
63 Study of the relationship between blood lipid and distant metastasis of hormone receptor negative breast cancer and its therapeutic effect
PANG Zi-juan
Objective To study the relationship between blood lipid and distant metastasis of hormone receptor negative breast cancer and its therapeutic effect.Methods A total of 87 patients with hormone receptor-negative breast cancer admitted from July 2012 to September 2016 in our hospital were selected as research subjects.According to distant metastasis or not,they were divided into two groups.Among them,38 patients without distant metastasis were classified into group A,and the remaining 49 cases with distant metastasis were categorized into group B.The complete data in these participants were collected in order to observe the changes in blood lipid levels,and explore the relationship between blood lipids and hormone receptor-negative breast cancer distant metastasis and its therapeutic effect.Results There were significant differences in tumor size,lymph node metastasis,hypertriglyceridemia，hypercholesteremia,and high low-density lipoprotein cholesterol(LDL-C)between the two groups(P＜0.05).The differential data were included in the Logistic regression equation and all of them belonged to risk factors of distant metastasis.After treatment，the triglyceride(TG)level in the PR group was significantly lower than that before treatment with a statistical difference(P＜0.05).Conclusion The level of serum lipids is associated with the distant metastasis of hormone receptor negative breast cancer to some extent.Effective treatment can significantly relieve the blood lipid level and the change of blood lipid level can be used as an important index to diagnose the distant metastasis and the therapeutic effect.
2018 Vol. 25 (14): 63-65 [Abstract] ( 179 ) HTML (31 KB)  PDF  (0 KB)  ( 32 )
66 Clinical study of hepatic arterial chemoembolization in the treatment of primary liver cancer
CHEN Zuo-bo；LIU Qiu-fang；HONG Ke-zhong
Objective To investigate the clinical effect of hepatic arterial chemoembolization in the treatment of primary liver cancer.Methods A total of 100 patients with primary liver cancer who were admitted to our hospital from January 2010 to May 2014 were selected as the study subjects and randomly divided into observation group and control group,50 patients in each group.The patients in the observation group were treated with hepatic arterial chemoembolization for clinical treatment.The patients in the control group were treated with supportive therapy for clinical treatment.After the end of treatment,the clinical efficacy,progression-free survival(PFS),overall surviva(OS),and incidence rate of adverse reactions were observed and recorded in both groups,and comparative analysis was carried out.Results There was no significant difference in objective remission rate and disease control rate between the two groups(P＞0.05);the mean values of PFS and OS in the observation group was(11.25±0.84)months and(18.57±0.99)months respectively.The control group was(7.51±0.67)months and(17.03±0.89)months respectively.The comparative analysis showed that the observation group was significantly higher than that in the control group in terms of the mean value of PFS(P＜0.05).However,there was no significant difference in the mean value of OS(P＞0.05);both groups showed different degrees of adverse reactions.The incidence rate of nausea and vomiting was higher in the observation group than that in the control group(P＜0.05);all adverse reactions were relieved or disappeared after symptomatic treatment,and there was no serious effects on the treatment for patients.Conclusion Hepatic arterial chemoembolization has a significant therapeutic effect in the treatment of primary liver cancer.The treatment method can effectively improve the patient′s survival status,increase the patient′s survival time and survival rate,so it is worthy of learning and promotion in the clinical practice.
2018 Vol. 25 (14): 66-68 [Abstract] ( 162 ) HTML (33 KB)  PDF  (0 KB)  ( 23 )
69 Effect of surgery combined with131I and Thyroid Tablets in the treatment of thyroid papillary carcinoma
131I and Thyroid Tablets in the treatment of thyroid papillary carcinoma[J]. 中国当代医药, 2018,25(14): 69-71')" href="#"> GAO Jun
Objective To investigate the effect of surgery combined with131I and Thyroid Tablets in the treatment of papillary thyroid carcinoma.Methods 78 patients with thyroid papillary carcinoma who were treated in the department of general surgery in our hospital from March 2013 to March 2014 were randomly divided into two groups,39 cases in each group.The control group was given thyroidectomy via endoscopic chest-breast approach.On this basis,the observation group was given131I and Thyroid Tablets for treatment.Three-year survival rate,recurrence rate and postoperative cytokines levels were compared between the two groups.Results The 3-year survival rate in the observation group was significantly higher than that in the control group,while the recurrence rate was significantly lower than that in the control group,the differences were statistically significant(P＜0.05);serum tumor suppressor gene(p53),Fas,TNF-α and CyclinE protein in the two groups at 3 months and 6 months after treatment were compared with those immediately after the surgery,the differences were statistically significant(P＜0.05);the levels of p53,Fas,TNF-αand CyclinE in the observation group at 3 months and 6 months after treatment were significantly different from those in the control group(P＜0.05).Conclusion Surgery combined with131I and Thyroid Tablets has a significant effect in the treatment of papillary thyroid carcinoma,which can continue to inhibit tumor development,extend the life cycle and reduce the recurrence rate,and has a positive clinical significance.
2018 Vol. 25 (14): 69-71 [Abstract] ( 144 ) HTML (36 KB)  PDF  (0 KB)  ( 23 )
72 Effect comparison of laparoscopic extensive hysterectomy and traditional laparotomy in the treatment of cervical cancer
LIU Yang；GUO Duan-ying；LI Shi-tong；ZHANG Ping
Objective To investigate and analyze the effect of laparoscopic extensive hysterectomy and traditional laparotomy on cervical cancer.Methods A total of 154 patients with cervical cancer treated in our hospital or Longgang Central Hospital from June 2015 to July 2017 were enrolled.They were randomly divided into two groups by a random number table with 77 cases in each group.In the control group,traditional laparotomy was used,while in the observation group,laparoscopic extensive hysterectomy was adopted.The therapeutic effect in the two groups was compared.Results The operation time,exhaust time and hospital stay in the observation group were shorter than those in the control group(P＜0.05),amount of bleeding was lesser than those in the control group,the differences were statistically significant(P＜0.05).The incidence in the observation group and the control group was 37.7%and 36.4%respectively without a significant difference(P＞0.05).Conclusion Compared with the traditional laparotomy,laparoscopic extensive hysterectomy for cervical cancer can effectively shorten the operation time,reduce the amount of bleeding,speed up the recovery,and will not increase the postoperative complications.
2018 Vol. 25 (14): 72-74 [Abstract] ( 169 ) HTML (32 KB)  PDF  (0 KB)  ( 29 )
75 Comparison of the effects of different surgical methods on the intestinal barrier function of gastric cancer
LIU Peng ；SHE Xiao-chen
Objective To explore the effect of two different radical gastrectomy on the intestinal barrier function of the patients.Methods All of 80 cases were selected from January 2012 to December 2017 in our hospital and medicine from gastric cancer patients,divided into laparotomy group according to the different surgical methods(40 cases)and laparoscopic group(40 cases),the operation time,with intestinal function recovery time,recovery time of bowel sounds,the first exhaust time.were compared between twu groups.Results The operative time of laparoscopic group was significantly longer than that in the laparotomy group,the difference was statistically significant(P＜0.05）;laparoscopic group the intestinal function recovery time,recovery time of bowel sounds,the first exhaust time,first defecation time,eating time and postoperative nausea and vomiting symptom duration was shorter than that in the laparotomy group,the differences were statistically significant (P ＜0.05）.3 and 5 d after operation,the DAO level and D-lactic acid level in the laparoscopic group were lower than those in the laparotomy group(P＜0.05）.There was no significant difference in DAO level and D-lactate level between the two groups after 7 d,and the differences were not statistically significant(P＞0.05）.Conclusions Radical resection of gastric cancer will cause some interference on the intestinal barrier function of patients,including laparoscopic surgery on patients with intestinal barrier interference,postoperative recovery of intestinal barrier function rapidly,although laparoscopic surgery time is too long,but with faster postoperative recovery,has broad application value.
2018 Vol. 25 (14): 75-78 [Abstract] ( 178 ) HTML (35 KB)  PDF  (0 KB)  ( 34 )
79 Comparison of preventive cervical lymph node dissection and conventional total thyroidectomy for thyroid cancer
ZHANG Wen-jie
Objective To investigate the effect comparison of preventive cervical central lymph node dissection and conventional total thyroidectomy in the treatment of thyroid cancer.Methods The clinical data from 50 patients with thyroid cancer who were admitted to our department from January 2007 to January 2012 were analyzed.According to different surgical methods,they were divided into control group(n=20,traditional total thyroidectomy)and observation group(n=30,preventive cervical central lymph node dissection).The operative time,intraoperative blood loss,incidence of temporary and permanant hypocalcemia,recurrence rate 5 years after surgery,incidence of postoperative cervical lymph node metastasis and survival rate in two groups were observed.Results The operative time in the observation group was longer than that in the control group.The intraoperative blood loss was more,the 5-year recurrence rate after surgery,postoperative cervical lymph node metastasis rate,and the survival rate were all lower compared with those in the control group.The differences were statistically significant(P＜0.05）.There was no significant difference in the incidence of temporary/permanent hypocalcemia between the two groups(P＞0.05）.Conclusion Preventive cervical central lymph node dissection for thyroid cancer patients can reduce the incidence of hypocalcemia and obtains a good prognosis,which is worthy of clinical application and promotion.
2018 Vol. 25 (14): 79-81 [Abstract] ( 156 ) HTML (30 KB)  PDF  (0 KB)  ( 31 )
82 Effect of laparoscopic radical resection of prostate cancer in the treatment of early localized prostate cancer
YANG Yue
Objective To investigate the clinical efficacy of laparoscopic radical resection of prostate cancer in the patients with early localized prostate cancer.MethodsSixty-two patients with early-stage localized prostate cancer who were admitted to the department of urology in our hospital from June 2016 to June 2017 were selected as the study subjects.According to the random number table method,they were divided into observation group (31 cases)and control group (31 cases).The observation group was given laparoscopic radical resection of prostate cancer.The control group was given traditional open surgery for treatment.The operation situation and postoperative urodynamic parameters were compared between the two groups.Results Compared with the control group,the time of surgical operation,bleeding time during the surgical operation,the recovery time of postoperative gastrointestinal function,the removal time of drainage tube,and the average length of hospital stay in the observation group were shorter than those in the control group,bleeding time during the surgical operation was lesser than those in the control group and the differences were statistically significant(P＜0.05）.The testing results of postoperative urodynamic parameters such as BC,PVR,Qmax in the observation group were all better than those in the control group after the surgery,and the difference was statistically significant(P＜0.05）.The postoperative complication rate in the observation group was significantly lower than that in the control group.The quality of life scores at the 6-month follow-up period were significantly higher than those in the control group，and the differences were statistically significant(P ＜0.05）.Conclusion For the patients with early localized prostate cancer who have undergone clinical treatment,the application of laparoscopic radical section of prostate cancer can significantly improve the quality of surgery,accelerate the recovery process,improve urodynamics,improve long-term quality of life,and have a high degree of safety,which has a higher value of promotion and application.
2018 Vol. 25 (14): 82-84 [Abstract] ( 153 ) HTML (33 KB)  PDF  (0 KB)  ( 29 )
85 Risk factors for coronary artery lesions in children with Kawasaki disease
LI Zhi-wen
Qbjective To investigate the coronary artery lesions in Kawasaki disease patients and risk factors analysis.Methods From October 2014 to October 2016,the selection of Guangming District of Shenzhen City People′s Hospital Neonatal from Kawasaki disease 30 cases as the research object,according to the children with or without coronary artery lesions as grouping criteria,were divided into control group(n=23,without coronary artery lesions)and study group(n=7,coronary artery lesions).A comparative analysis of indicators related symptoms index of the two groups of Kawasaki disease and laboratory,to clear the disease risk factors associated with coronary artery lesion.Results Factors associated with coronary artery disease patients include Kawasaki damage fever time,platelet index,erythrocyte sedimentation rate,CRP index,hemoglobin index etc.Conclusion The risk factors for coronary artery lesions mainly include Kawasaki disease duration of fever,C-reactive protein (CRP),platelet,hemoglobin,erythrocyte sedimentation rate,can be combined with clinical risk factors as predictors.
2018 Vol. 25 (14): 85-87转91 [Abstract] ( 156 ) HTML (33 KB)  PDF  (0 KB)  ( 32 )
88 Influence of touching combined with blue ray on serum total bilirubin and growing development in neonatal hyperbilirubinemia
PENG Li-yuan； ZHOU Wen-juan
Objective To discuss the effect of touch and blue light irradiation on serum total bilirubin level and growth and development of hyperbilirubinemia neonates.Methods70 cases of neonatal hyperbilirubinemia in our hospital from March 2016 to March 2017 were randomly divided into observation group and control group,35 cases in each group.All of them were given blue ray and routine care,while newborns in observation group were given touching care additionally.The total serum bilirubin was detected before and after treatment.Daily weight,daily intake of milk,daily stool frequency and daily sleep duration were used to evaluate the growing development.Results Total serum bilirubin between two groups had no difference before treatment(P＞0.05),and total serum bilirubin in observation group were lower than that in control group after 1 and 3 days treatment(P＜0.05).Daily weight,daily intake of milk,daily stool frequency and daily sleep duration had no difference before treatment(P＜0.05),and all of them in observation were better than those in control group after treatment,the differences were statistically significant(P＜0.05).Conclusion Touching combined with blue ray is be conducive to decreasing total serum bilirubin,and promoting the growing development via improving weight growth,milk intake,stool frequency and sleep time.
2018 Vol. 25 (14): 88-91 [Abstract] ( 137 ) HTML (34 KB)  PDF  (0 KB)  ( 25 )
92 Clinical effect of Carboprost Tromethamine Injection in the prevention and treatment of uterine atony postpartum hemorrhage
FENG Wen-li ；CHEN Dan-mian
Objective To observe the clinical effict of Carboprost Tromethamine Injection in the prevention and treatment of uterine atony postpartum hemorrhage.MethodsAltogether 114 cases of pregnant women who gave birth in our hospital and suffered from postpartum hemorrhage caused by uterine atony from September 2016 to September 2017 were selected as the object of the research and divided into control group and observation group according to random number table method,57 cases in each group.After fetal childbirth,the control group was given oxytocin treatment,the observation group was received the treatment of Carboprost Tromethamine Injection.The hemorrhage of parturients at postpartum 0.5,0.5-1.5 and 1.5-24 h,the decrease value in hemoglobin (Hb)levels and changes in blood pressure and pulse at postpartum 24 h as well as drug adverse reactions were compared between two groups.Results The hemorrhage at postpartum 0.5,0.5-1.5 and 1.5-24 of observation group was significantly lower than that of control group (P＜0.05);the decrease value in hemoglobin (Hb)levels of observation group at postpartum 24 h was lower than that of control group(P＜0.05).No statistically significant difference was seen in the changes in blood pressure and pulse at postpartum 24 h between the two groups(P＞0.05);the two groups had no serious drug adverse reactions after treatment.Conclusion Carboprost Tromethamine Injection has more obvious advantages in prevention and treatment of postpartum hemorrhage due to uterine inertia than oxytocin,significantly reducing the amount of postpartum hemorrhage,ensuring the stable vital signs and no serious adverse reactions.It is worthy of clinical promotion.
2018 Vol. 25 (14): 92-94 [Abstract] ( 158 ) HTML (32 KB)  PDF  (0 KB)  ( 34 )
95 Effect of Goserelin combined after laparoscopic surgery treating chocolate cyst
LI Xiao-hong
Objective To compare the clinical effect of laparoscopic surgery in patients with chocolate cyst combined with Gestrinone and Goserelin treatment.Methods 72 patients with chocolate cyst treated in our hospital from January 2014 to November 2015 were selected as observation subjects and divided into control group (n=36)and observation group(n=36)according to random number table method.Both groups were given laparoscopic treatment.On this basis,the patients in the control group were given Gestrinone and the patients in the observation group were given Goserelin.The levels of hormone,clinical efficacy and pregnancy rate in both groups were statistically analyzed.Results In hormone levels,two groups of after treatment,serum follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol(E2)level were significantly decreased(P＜0.05),but the groups of serum FSH,there was no significant difference between the level of LH(P＞0.05),and the serum E2level of observation group was significantly lower than the control group(P＜0.05).In terms of the total effective rate,pregnancy rate,the observation group were higher than that in the control group,the data were 83.3%vs.61.1%,63.9%vs.38.9%,there was a significant difference between groups(P＜0.05).Conclusion The clinical effect of Goserelin for chocolate cyst patients after laparoscopic surgery is more significant,not only can reduce the hormone level of patients but also can improve the pregnancy rate,which is worthy of further application and clinical reference.
2018 Vol. 25 (14): 95-97 [Abstract] ( 166 ) HTML (32 KB)  PDF  (0 KB)  ( 33 )
98 Influence of intravenous infusion for the hemorheology and fetal blood flow of pregnant women with critical amniotic fluid oligohydramnios in late pregnancy
XUE Jie-hao ；YOU Hai-ying ；YI Ling ；QIU Xue-ling ；LIANG Shu-jun
Objective To observe and investigate the influence of intravenous infusion for the hemorheology and fetal blood flow of pregnant women with critical amniotic fluid oligohydramnios in late pregnancy.Methods 120 pregnant women with critical amniotic fluid oligohydramnios in late pregnancy from January to December 2016,were selected for the study,and they were randomly divided into control group and observation group,60 cases in each group.The control group were without intravenous infusion,the observation group were treated with intravenous infusion.Then the hemorheology,fetal umbilical artery blood flow indexes and pregnancy outcome of two groups before and after the intervention were analyzed and compared.Results The hemorheology and fetal umbilical artery blood flow indexes of two groups before the intervention were compared,the difference were not statistically significant(P＞0.05),the hemorheology,fetal umbilical artery blood flow indexes and the rate of abnormal pregnancy in observation group after the intervention were all lower than those of conrtrol group,the differences were statistically significant（P＜0.05）.Conclusion The influence of intravenous infusion for the hemorheology and fetal blood flow of pregnant women with critical amniotic fluid oligohydramnios in late pregnancy are better,and it has certain clinical significance for the improvement of fetus and pregnant women′state.
2018 Vol. 25 (14): 98-100 [Abstract] ( 169 ) HTML (34 KB)  PDF  (0 KB)  ( 28 )
101 Relationship between the glycated hemoglobin levels and pregnancy outcome of pregnant women pregnancy associated with diabetes
CHEN Rui-yan
Objective To explore relationship between the glycosylated hemoglobin levels and pregnancy outcome of pregnant women pregnancy associated with diabetes and provide the basis for clinical treatment.Methods All of 90 cases of pregnant women pregnancy associated with diabetes from September 2014 to September 2017 treated in our hospital were observation group.Besides,50 pregnant women who were adopted healthy examination during the same period were selected as control group.After 1 week treatment in the observation gorup,the patients were divied group A and group B according to blood glucese normal or not normal.Measuring the different stages of observation group and control group in patients with glycosylated hemoglobin levels,follow-up until delivery,maternal observation all pregnant women delivery end,analyze its relationship with glycosylated hemoglobin content,and statistical analysis.Results The hemoglobin content of the patients in the observation group was significantly higher than that in the control group,the difference was statistically significant by statistical analysis (P＜0.05).The incidence of adverse childbirth outcomes in the observation group was significantly higher than that in the control group,and statistically significant difference was found (P＜0.05).The incidence of adverse childbirth outcomes was significantly higher in patients with glycated hemoglobin than that of 6.5%percent of the patients with glycated hemoglobin ＜6.5%,the difference was significant(P＜0.05).Conclusion High glycosylated hemoglobin is positively correlated with the outcome of adverse childbirth outcomes in patients with gestational diabetes mellitus.Active and effective monitoring and control of blood glucose during pregnancy can significantly improve the outcome of maternal childbirth.
2018 Vol. 25 (14): 101-103 [Abstract] ( 141 ) HTML (34 KB)  PDF  (0 KB)  ( 26 )
104 Effect of pregnant women school training model on improving pregnant care cognition and self-care ability
XIAO Xiao-li
Objective To observe the effect of pregnant women school training model on improving pregnant care cognition and self-care ability.Methods 60 pregnant women with routine pregnant school training in our hospital from July to December 2016 were selected as control group,and 60 pregnant women with improved pregnant school training model in our hospital from July to December 2017 were selected as observation group.The control group was given routine pregnant school training model,the observation group was given improved pregnant school training model.The pregnant care cognition,self-care ability,delivery mode of two groups before and after intervention were compared.ResultsBefore intervention,the scores of pregnant care cognition,self-care ability of two groups were compared,there was no statistical difference(P＞0.05).After intervention,the scores of pregnant care cognition,self-care ability in observation group were higher than those in control group (P＜0.05).The natural delivery rate of observation group was higher than that of control group,and the cesarean section rate was lower than control group,the differences were statistically significant(P＜0.05).Conclusion Pregnant women school training model could improve pregnant care cognition and self-care ability,decrease the cesarean section rate,guarantee maternal and child health,hich has clinical promotional value.
2018 Vol. 25 (14): 104-106 [Abstract] ( 136 ) HTML (31 KB)  PDF  (0 KB)  ( 34 )
107 Clinical effect of laparoscopic myomectomy for the treatment of uterine fibroids
TANG Mu-qun
Objective To explore the clinical effect of laparoscopic myomectomy for the treatment of uterine myoma.Methods 200 cases of hysteromyoma in our hospital from July 2015 to June 2017 were selected as the research objects.They were divided into control group and observation group according to the order of admission,100 cases in each group.The control group was treated with traditional laparotomy,and the observation group was treated with laparoscopic myomectomy.The clinical effects of the two groups were compared and analyzed.Results The intraoperative blood loss in the observation group was significantly lesser than that in the control group,and the time of operation,the time of the first evacuation and the length of hospitalization were significantly shorter than those in the control group(P＜0.05).The total incidence of complications was 4.00%in the observation group and 21.00%in the control group.The total incidence of complications in the observation group was significantly lower than that in the control group,the difference was significant(P＜0.05).The residual rate of uterine fibroids in the control group and observation group,recurrence rate,pregnancy rate difference was not significant(P＞0.05).Conclusion Endoscopic myomectomy hysterectomy for the treatment of uterine fibroids,to ensure the prognosis,optimize surgical indicators,reduce the incidence of complications,to ensure surgical results,promote the use of high value.
2018 Vol. 25 (14): 107-109 [Abstract] ( 128 ) HTML (36 KB)  PDF  (0 KB)  ( 35 )
110 Influence of two kinds of appliance on periodontal condition and alveolar bone condition in adult patients with periodontal disease
CAO Xin
Objective To investigate the influence of two kinds of appliance on periodontal condition and alveolar bone condition in adult periodontal disease patients.MethodsA total of 100 adult periodontal disease patients who came to our hospital for orthodontic treatment of periodontal disease from June 2015 to May 2017 were selected as the study subjects.Among them,52 patients with Damon Q high torque appliance were selected as the observation group,and the other 48 patients with conventional MBT straight wire appliance were used as the control group.The improvement of periodontal tissue and alveolar bone condition before and after treatment were compared between the two groups.Results There was no significant difference in PLI,GI,PD,SBI,BOP and CAL before treatment between the two groups(P＞0.05).After 6 months treatment,the above indexes in each group were compared with those before treatment,there was no significant difference between the two groups (P＞0.05).There was no significant difference in the indexes of PLI,GI,PD,SBI,BOP and CAL between the two groups after 6 months treatment(P＞0.05).There was no significant difference in the alveolar condition between the two groups before treatment(P＞0.05).After 6 months of treatment,the alveolar bone condition of both groups improved significantly compared with before treatment(P＜0.05),but the difference between the two groups after 6 months treatment was no statistical significance (P＞0.05).Conclusion The adult periodontal disease patients take different appliance for correction,to ensure the oral hygiene under the premise of its periodontal condition can not be different due to different appliances and at the same time through the appliance after treatment,the patient′s alveolar bone condition can be significantly improved.
2018 Vol. 25 (14): 110-112转115 [Abstract] ( 146 ) HTML (34 KB)  PDF  (0 KB)  ( 24 )
113 Clinical effect of fenestration decompression in the treatment of large cyst in oral and maxillofacial region
QIU Fang-song ；ZHENG Jun ；XIE Yuan-hong； HONG Jin-chao
Objective To explore the clinical effect of fenestration decompression in the treatment of large cyst in oral and maxillofacial region.Methods Forty patients with oral and maxillofacial cysts admitted in our hospital from January 2010 to December 2017 were selected as research subjects,and all patients were divided into the study group (n=20)and the reference group (n=20)according to the random number table method.Patients in the study group were treated with fenestration decompression,and the patients in the reference group were treated by traditional cystectomy.The operation related indicators,clinical efficacy and the incidence of complications were compared between the two groups.Results The operation time and hospitalization time in the study group were significantly shorter than those in the reference group,the amount of bleeding and postoperative complications in the study group were significantly lower than those in the reference group,with significant difference (P＜0.05).The total effective rate of clinical treatment in the study group was significantly higher than that in the reference group,with significant difference(P＜0.05).Conclusion O-ral and maxillofacial cyst patients undergoing fenestration decompression can fundamentally improve the clinical manifestations,shorten the operation time,control the volume of blood loss and achieve the expected clinical curative effect.The safety of this surgical plan is also outstanding,and the patient′s hospitalization time and postoperative side effects are well controlled,on the whole the clinical application of fenestration decompression value is more obvious.
2018 Vol. 25 (14): 113-115 [Abstract] ( 128 ) HTML (31 KB)  PDF  (0 KB)  ( 23 )
116 Influence of Minocycline Hydrochloride on the levels of prostaglandin E2 and human matrix metalloproteinase-8 in gingival crevicular fluid in the patients with fixed orthodontic gingivitis
2 and human matrix metalloproteinase-8 in gingival crevicular fluid in the patients with fixed orthodontic gingivitis[J]. 中国当代医药, 2018,25(14): 116-118')" href="#"> YAN Ming；SONG Yao-guang
Objective To investigate the influence of Minocycline Hydrochloride on the levels of prostaglandin E2(PGE2),interleukin-1β (IL-1β)and human matrix metalloproteinase 8(MMP-8)in gingival crevicular fluid in the patients with fixed orthodontic gingivitis.Methods From November 2015 to August 2017,80 patients admitted to our hospital with fixed orthodontic gingivitis were selected and divided into the control group and the observation group according to the random digital table method,40 cases in each group.The control group was given conventional oral health care,and the observation group was given combined Minocycline Hydrochloride,once a week.After four weeks,the improvement of bleeding index(SBI)and exploration depth (PD)before and after treatment was compared.The improvement of PGE2,IL-1β and MMP-8 levels in gingival crevicular fluid was compared between the two groups after 4 weeks.Results After treatment,the SBI and PD of gingival sulcus in the observation group were lower than those in the control group,and the difference was statistically significant (P＜0.05).After treatment,the levels of PGE2,IL-1β and MMP-8 in gingival crevicular fluid in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).Conclusion Minocycline Hydrochloride can effectively improve the fixed orthodontic gingivitis and reduce the inflammation index and pain media levels in gingival crevicular fluid,which is worthy of popularization.
2018 Vol. 25 (14): 116-118 [Abstract] ( 130 ) HTML (37 KB)  PDF  (0 KB)  ( 24 )
119 Value analysis of patient-controlled analgesia by combined spinal-epidural anesthesia for labor analgesia
HOU Heng-sheng；WANG Wen-min；LIU Yue-mei3

Objective To investigate the clinical value of patient-controlled analgesia by combined spinal-epidural anesthesia for labor analgesia.Methods From June to September 2017,80 cases of primipara with single infant and head delivery who were admitted to our hospital were selected as the subjects,and divided into the control group and analgesia group by random number table method,40 cases in each group.The control group was given routine treatment,without analgesic treatment.In the analgesia group,when cervix was open to 2 cm,epidural puncture was carried out at L3-4intervertebral space,and then subarachnoid puncture was carried out by placing lumbar puncture needle.One mg Bupivacaine was injected if successful.PCEA then injected with a mixture of 0.1%Ropivacaine and 2 μg/ml Ffentanyl.The analgesic effect,labor duration,mode of delivery,oxytocin use rate and neonatal scoring were observed in the two groups.Results The VAS scores in the analgesia group were significantly lower than those in the control group at 5 min,40 min,70 min and 100 min respectively,the differences were statistically significant(P＜0.05).The duration of active period was shorter and the second stage of labor in the analgesia group was longer than those in the control group,all within the normal time range,and the difference was statistically significant(P＜0.05).There was no significant difference in the third stage of labor(P＞0.05).The use rate of oxytocin in the analgesia group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).There was no statistically significant difference in the mode of delivery between the two groups(P＞0.05).Neonatal score between the two groups showed no statistically significant difference(P＞0.05).Conclusion The combined spinal-epidural anesthesia for labor analgesia has an exact effect,which significantly reduces the VAS pain score of each stage of labor in puerpera,shortens the time of active period,extends the second stage of labor,has no impact on the third stage of labor,increases the use rate of oxytocin,it has no impact on the mode of delivery and neonatal score,which has a high clinical application value.
2018 Vol. 25 (14): 119-121转125 [Abstract] ( 130 ) HTML (35 KB)  PDF  (0 KB)  ( 34 )
122 Influence of preoperative injection of different vasoactive drugs on the maternal and neonatal during the spinal-epidural anesthesia of cesarean section in severe pre-eclampsia patients
ZHANG Jia-ze；ZHANG Xiao
Objective To study the influence of preoperative injection of different vasoactive drugs on the maternal and neonatal during the spinal-epidural anesthesia of cesarean section in severe pre-eclampsia patients.Methods From December 2016 to December 2017,60 severe pre-eclampsia patients undergoing the spinal-epidural anesthesia in our hospital were selected as the subjects,and divided to three groups by radom digital table method,20 cases in each group.Group A took the pumping injection of ephedrine (2 mg/min).Group B took the pumping injection of norepinephrine(25 ug/min).Group C took the equivalent normal saline.The final outcomes were observed.Results At 1,10,12 and 15 min,there was no significant difference in the blood pressure among three groups(P＞0.05).At 3,5 and 7 min,the blood pressure in Group C was significantly lower than that in Group A and Group B (P＜0.05).At 1 min,there was no significant difference in the heart rate among three groups(P＞0.05).At 3,5,7,10,12 and 15 min,the heart rate in Group C was significantly higher than that in Group A and Group B,the difference was statistically significant(P＜0.05).After 5 min,the heart rate in Group B was significantly higher than that in Group A,the difference was statistically significant(P＜0.05).There were no significant a difference in the lactic acid,PCO2,PO2,BE and pH among three groups (P＞0.05).The incidence rate of nausea and vomiting in Group A and Group B was lower than that in Group C,the difference was statistically significant(P＜0.05).Conclusion During the spinal-epidural anesthesia of cesarean section,the preoperative injection of Ephedrine and Norepinephrine can maintain the hemodynamics stability,keep the blood concentration and improve the maternal and neonatal prognosis.
2018 Vol. 25 (14): 122-125 [Abstract] ( 147 ) HTML (34 KB)  PDF  (0 KB)  ( 42 )
126 Review and analysis of outpatient prescriptions in our hospital from January to June in 2017
PENG Yan-qiong
Objective To know the quality and medication situation of outpatient prescriptions in our hospital and promote rational drug use in clinic through the comment and analysis of outpatient prescriptions.Methods The outpatient prescriptions during January to June in 2017 were reviewed by retrospective analysis.The basic situation and unreasonable situation of the prescription were analyzed by using Excel software.Results A total of 229 579 outpatient prescriptions during January to June in 2017 were extracted.The average amount of the prescriptions were 104.47 yuan,the use rate of the generic name of the drug was 100.00%,the rate of antibiotic usage was 23.70%,the application rate of antibiotics for intravenous use was 6.67%and the average drug use categories in outpatient prescriptions were 3.61 kinds.There were 229 433 reasonable prescriptions,and the rational rate of prescription was 99.94%.Of the 146 irrational prescriptions,25 were nonstandard(17.12%),121 were inappropriate(82.88%),and 0 were abnormal.Conclusion The rational rate of outpatient prescriptions in our hospital is high,but there are still unreasonable prescriptions.The hospital should continue to adhere to and improve the prescription evaluation system,improve the quality of the prescription,further promote the clinical rational use of drugs,and ensure the safety of the patients.
2018 Vol. 25 (14): 126-128 [Abstract] ( 134 ) HTML (31 KB)  PDF  (0 KB)  ( 31 )
129 Analysis of the effect of Alprostadil in the treatment of elderly patients with diabetes and chronic kidney disease
PENG Xiang-hang；CHEN Zhen-hua；QIU Yu；CHEN Xin-yu；LIU Hui-dan
Objective To investigate the clinical efficacy of Alprostadil in the treatment of elderly patients with diabetes and chronic kidney disease.Methods A total of 58 elderly patients with diabetes and chronic kidney disease treated in Changping Hospital in Dongguan City from October 25,2016 to October 25,2017 were selected as subjects.They were divided into control group and observation group according to the principle of random sampling,29 cases in each group.The patienys in control group were treated with conventional treatment,and the patients in observation group were given Alprostadil on basis of routine treatment.The clinical efficacy,serum creatinine(Cr),24 h urinary albumin excretion rate(24 h UAER),cystatin C,serum creatinine clearance rate (Ccr)levels and adverse reactions were compared between the two groups.Results After treatment,the Cr,24 h UAER and cystatin C in the observation group were lower than those in the control group,and the Ccr was higher than that in the control group,the differences were statistically significant(P＜0.05).The total effective rate of clinical treatment in the observation group was 93.1%,which was significantly higher than that in the control group(68.97%),and the difference was statistically significant(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups(P＞0.05).Conclusion In clinic,elderly patients with diabetes and chronic kidney disease can be treated with a certain dose of Alprostadil at the same time of routine treatment,which can improve the clinical efficacy and quality of life.
2018 Vol. 25 (14): 129-131 [Abstract] ( 154 ) HTML (34 KB)  PDF  (0 KB)  ( 32 )
132 Clinical efficacy of Montelukast Sodium combined with Salmeterol and Fluticasone Propionate Powders for Inhalation in treatment of asthma
MO Jian-rong ；HUANG Nian-hua； LI Xiao-hua
Objective To investigate the clinical effect of Montelukast Sodium combined with Salmeterol and Fluticasone Propionate Powders for Inhalation in treatment of asthma.Methods A total of 100 patients with asthma who were admitted to the department of respiratory medicine of our hospital from July 2014 to September 2016 were selected as subjects.They were divided into two groups according to the random number table method,50 cases in eacgh group.The patients in the control group were given conventional treatment with Salmeterol and Fluticasone Propionate Powders for Inhalation,while the patients in the analysis group were added to the treatment of Montelukast Sodium on the basis of the control group.The lung function indicators(lung capacity,exhalation volume,maximum expiratory flow rate),the therapeutic effect and disappearance time of various clinical symptoms of the two groups were compared.Results Before treatment,there was no significant difference in lung function indicators between the two groups (P＞0.05).After treatment,the levels of lung function indicators in the analysis group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of treatment in the analysis group was 96.00%(48/50),which was significantly higher than 68.00%(34/50)in the control group,and the difference was statistically significant(P＜0.05).The disappearance time of cough and asthma in the analysis group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Montelukast Sodium combined with Salmeterol and Fluticasone Propionate Powders for Inhalation is more effective in treatment of asthma.It can effectively shorten the disappearance time of symptoms and improve lung function.It has clinical application value.
2018 Vol. 25 (14): 132-134转138 [Abstract] ( 167 ) HTML (35 KB)  PDF  (0 KB)  ( 37 )
135 Distribution and drug resistance of respiratory pathogenic bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease in the First Hospital of Traditional Chinese Medicine in Zhanjiang City from 2016 to 2017
ZHENG Li-ming；LIU Hua-zhen；CHEN Zhan
Objective To analyze the distribution and drug resistance of respiratory pathogens bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease in the the First Hospital of Traditional Chinese Medicine in Zhanjiang City from January 2016 to December 2017,so as to provide guidance for rational use of antibiotics in clinic.Methods A total of 300 patients with acute exacerbation of chronic obstructive pulmonary disease from January 2016 to December 2017 in the the First Hospital of Traditional Chinese Medicine in Zhanjiang City were checked and analyzed for respiratory tract pathogen detection and bacterial susceptibility test results,and the distribution and drug resistance of pathogenic bacteria were obtained by retrospective analysis.Results Of the 300 samples,326 strains were detected,of which 126 were Gram-positive bacteria,account for 38.66%,182 strains of Gram-negative bacteria,accounting for 55.82%,18 strains of Fungi,accounting for 5.52%.The resistance rates of Staphylococcus aureus to Penicillin,Oxacillin were higher than 50%,while no drug resistance to Vancomycin and Teicoplanin was demonstrated.The resistance rates of Staphylococcus epidermidis to Penicillin,Oxacillin,Cefazolin,Ceftazidime and Cefoxitin were higher than 50%,however,it showed a low resistance rate for Gentamicin,Vancomycin and Teicoplanin.The resistance rates of Pseudomonas aeruginosa to Piperacillin,Amikacin,Gentamycin,Ciprofloxacin and Levofloxacin were higher than 20%,and the resistance rate to Imipenem were low.The resistance rate of Escherichia coli to Piperacillin,Amikacin,Gentamicin,Ciprofloxacin,Levofloxacin and Imipenem were higher than 20%.Conclusions The pathogenic bacteria of respiratory tract were mainly Gram-negative bacteria in the acute exacerbation period of chronic obstructive pulmonary disease in our hospital from from January 2016 to December 2017.The rate of drug resistance is high.In clinical practice,rational antimicrobial agents should be selected in combination with drug sensitivity test results.Meanwhile,the drug resistance monitoring should be strengthened to improve the clinical therapeutic effect.
2018 Vol. 25 (14): 135-138 [Abstract] ( 137 ) HTML (34 KB)  PDF  (0 KB)  ( 24 )
139 Clinical analysis of precaution postpartum hemorrhage by Oxytocin combined with Calcium Gluconate and Carboprost Tromethamine
PENG quan
Objective To investigate the effect of precaution postpartum hemorrhage by Oxytocin combined with Calcium Gluconate and Carboprost Tromethamine.Methods A total of 100 puerperae treated in our hospital from January 2016 to January 2017 were selected as subjects,and they were divided into two groups by random paper grouping method,50 cases in each group.The observation group was treated with Carboprost Tromethamine and control group was treated with Oxytocin combined with Calcium Gluconate.The contraction effect,blood loss after 2,24 h,postpartum hemorrhage rate,third stage labor timeand the incidence of adverse reactions of puerperae in the two group were detected.Results The good contract rate of puerperae in the observation group was higher than control group,the blood loss after 2,24 h in the observation group were fewer than control group,third stage labor time in the observation group was less than control group,postpartum hemorrhage rate and incidence of adverse reactions in the observation group were lower than control group,the differences were statistical significance (P＜0.05).Conclusion The application of Oxytocin combined with Calcium Gluconate and Carboprost Tromethamine in puerpera,which could increase good contract result,decrease postpartum hemorrhage and incidence of adverse reactions,it is worth to be used.
2018 Vol. 25 (14): 139-141 [Abstract] ( 150 ) HTML (33 KB)  PDF  (0 KB)  ( 24 )
142 Effect observation of Lamivudine and Compound Glycyrrhizin combined with Reduced Glutathione on chronic hepatitis B associated liver cirrhosis
CHEN Shao-wen
Objective To explore the therapeutic value of Lamivudine and Compound Glycyrrhizin combined with Reduced Glutathione in joint application in patients with chronic hepatitis B associated liver cirrhosis.Methods A total of 56 patients with chronic hepatitis B associated liver cirrhosis treated in our hospital from October 2016 to December 2017 were selected as sujects.By computer randomization method,they were evenly divided into control group and experimental group,28 cases in each group.In the control group,Lamivudine was used,while in the experimental group,Compound Glycyrrhizin and Reduced Glutathione were added.The total bilirubin(TBil),aspartate aminotransferase(AST),alanine aminotransferase(ALT)levels and therapeutic effects were compared between the two groups.Results The levels of TBil,AST and ALT in the two groups after treatment were all lower than those before treatment,and the above mentioned indexes in the experimental group after treatment were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The total effectiveness rate in the experimental group was 92.86%,which was significantly higher than that of the control group accounting for 64.29%,the difference was statistically significant(P＜0.05).Conclusion Joint application of Lamivudine,Compound Glycyrrhizin and Reduced Glutathione for patients with chronic hepatitis B cirrhosis can effectively inhibit the replication of the virus and has positive clinical significance for prognosis improvement.
2018 Vol. 25 (14): 142-144 [Abstract] ( 131 ) HTML (24 KB)  PDF  (0 KB)  ( 25 )
145 Fixation methods and application efficacy of improvement of central venous catheter in ICU patients
JIANG Chang-ying；HUANG Xin-wu； WANG Feng-juan
Objective To explore the application effect of adhesive tape and cotton on fixing central venous catheter in intensive care unit(ICU)patients.Methods From July 2014 to December 2015,120 patients with indwelling central venous catheter in ICU ward of our hospital were selected as the control group.From January 2016 to June 2017,120 patients with indwelling central venous catheter in ICU ward of our hospital were selected as the experimental group.The fixation of fixed catheter connector of “Ren” type in a Chinese character with cross-fixed infusion connector was used in the control group,while in the experimental group,adhesive tape and cotton thread for fixing central venous catheter was adopted.The catheter displacement rate,tube detached rate and fixed time were compared between the two groups.Results In the experimental group,the rate of catheter displacement was lower than that in the control group,the incidence of tube detached due to unstable fixation was lower than that in the control group,the fixed time was longer compared to that in the control group(P＜0.05).Conclusion Adhesive tape+cotton central venous catheter fixation is significantly better than that by fixed catheter connector of “Ren” type in a Chinese character with cross-fixed infusion connector,which has a clinical value for promotion.
2018 Vol. 25 (14): 145-147 [Abstract] ( 147 ) HTML (31 KB)  PDF  (0 KB)  ( 21 )
148 Defect analysis based on homepage data of 2414 hospitalization medical records and pre-and post-interventional effect evaluation
LI Xiao-dan； XU Ming-dong
Objective To analyze the reasons for the defects of data in the homepage of hospitalization medical records and take some intervention measures so as to observe the improvement effect of the data and the coding quality in the homepage of the medical records before and after the intervention.Methods The coding for the home page of hospitalization medical records from September 2015 to March 2016 in our hospital was retrospectively reviewed.Altogether 1207 medical records were randomly selected as the pre-intervention group to find out the defects of the coding quality in the homepage of the medical records.The reasons for the defects were summarized and analyzed.After strengthened training of the clinicians and coders in our hospital,1207 hospitalization medical records from January to June in 2017 were randomly selected as the post-intervention group.The data and coding quality of 1207 hospitalization medical records were compared before and after training.Results The medical record defect rate of the pre-intervention group and post-intervention group was 76.5%and 15.9%,respectively.The data and coding quality of the homepage of the medical records in the post-intervention group were significantly higher than those in the pre-intervention group (P＜0.01).The main items of the coding defect included the missing or wrong basic information,error information in doctor′s main diagnosis and selection,missing or wrong surgical and operation information,and other information errors in the homepage of the medical records.Conclusion The coding defects in the front page of medical records is found through inductive analysis.And the policy of strengthening the responsibility of the clinicians is formulated to strengthen the training and study of how to fill in the homepage of the medical records,communication between the coders and the doctors,and management of the coding process of the medical records.It is the key to improve the coding quality of the homepage of the medical records,and also a bridge to establish good communication between the clinician and the medical record coders.
2018 Vol. 25 (14): 148-151 [Abstract] ( 144 ) HTML (35 KB)  PDF  (0 KB)  ( 31 )
152 Effect of postural nursing on the rehabilitation of patients after gastric endoscopic submucosal dissection
ZHENG Chuan-jiang；LUO Mei； TAO Jian； ZUO Zan ；LI Ting； DAI Ling-li；LI Ai-hua； LI Fang-fang
Objective To investigate the effect of postural nursing on the rehabilitation of patients after gastric endoscopic submucosal dissection(ESD).Methods From July 2016 to September 2017,72 patients underwent gastric ESD in our hospital were randomly divided into control group and observation group,36 patients in each group.The control group was given routine nursing.The observation group was treated with posture nursing on the basis of routine nursing.The symptoms of fullness,pain,belching and nausea,delayed bleeding and ulcer healing at 8 weeks after operation in the two groups were compared and analyzed statistically.Results There was no significant difference in the scores of epigastric fullness,epigastric pain,belching and nausea between the two groups at 1 d after operation (P＞0.05).The scores of abdominal fullness,abdominal pain and nausea symptoms in the observation group were lower than those in the control group at 3,7 d after operation (P＜0.05).The healing rate of ulcer in the observation group was higher than that in the control group at 8 weeks after operation(P＜0.05).There was no significant difference between the two groups(P＞0.05).Conclusion Postural nursing after gastric ESD can increase the patient′s comfort,promote ulcer healing,improve the recovery quality and satisfaction of the patients after operation.
2018 Vol. 25 (14): 152-154 [Abstract] ( 120 ) HTML (35 KB)  PDF  (0 KB)  ( 26 )
155 Effect of nursing in different positions for premature infants
HU Zhong-fang
Objective To explore the effect of different-position nursing in preterm infants.Methods 110 premature infants admitted to our hospital from January 2015 to December 2016 were selected as research objects,and divided into control group and observation group according to the principle of random drawing,with 55 cases in each group.The control group was supine and the observation group was prone.The effects of two groups of supine position on cardiopulmonary function,sleep,respiration and milk intake of premature infants were compared.Results Before nursing,there was no significant difference in heart rate and respiratory index between the two groups(P＞0.05).Heart rate and respiratory indicators of preterm infants in the observation group were significantly lower than those in the control group on the 3rd and 7thday after nursing,with statistically significant difference (P＜0.05).The heart rate and respiration of the observation group on the third day and the seventh day after nursing were significantly higher than those before nursing,and the difference was statistically significant(P＜0.05).The sleep time of preterm infants in the observation group on the third day and the seventh day was significantly longer than that of the control group,and the difference was statistically significant(P＜0.05).The daily milk intake of premature infants in the observation group was significantly higher than that in the control group on the 3rdand 7thday,with statistically significant difference(P＜0.05).Conclusion Compared with supine position,prone-position nursing has a significant effect on cardiopulmonary function,sleep apnea,and retention of stomach.It can contribute to the maturity of heart and lung function in preterm infants,improve the sleep quality,and create a good gastrointestinal development condition.
2018 Vol. 25 (14): 155-157 [Abstract] ( 142 ) HTML (36 KB)  PDF  (0 KB)  ( 33 )
158 Application of evidence based nursing in patients with shoulder and back pain after gynecological laparoscopic surgery
ZHANG Ping
Objective To investigate the effect of evidence-based nursing on postoperative shoulder and back pain after gynecological laparoscopic surgery.Methods The clinical data of 70 gynecological patients who underwent laparoscopic surgery in our hospital from July 2014 to July 2016 were analyzed.According to the operation time,the patients were divided into control group and nursing group,35 cases in each group.The control group was given conventional nursing methods,and the nursing group was given evidence-based nursing on the basis of conventional nursing.The postoperative pain,anxiety(SAS),depression(SDS)scores and patient satisfaction were compared between the two groups.Results After treatment,the pain rate in nursing group was significantly lower than that in control group,the difference was statistically significant(P＜0.05).The nursing satisfaction rate of the nursing group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).The degree of anxiety and depression in nursing group was lower than that in control group,and the difference was statistically significant(P＜0.05),and SAS and SDS scores in nursing group were lower than those in control group,and the difference was statistically significant(P＜0.05).Conclusion Evidence-based nursing intervention is effective in shoulder and back pain after gynecological laparoscopy.
2018 Vol. 25 (14): 158-160 [Abstract] ( 123 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
161 Clinical effect of nursing intervention on postpartum psychological status and compliance of pelvic floor rehabilitation nursing
FU You-qi
Objective To investigate the effect of primipara of obstetrics and gynecology on nursing compliance and psychology after receiving nursing intervention.Methods A total of 148 primipara admitted to our hospital from March 2014 to May 2016 were selected as the research objects,and randomly divided into study group and reference group,with 74 cases in each group.The study group was treated with targeted nursing intervention,while the reference group was treated with routine nursing.SDS and SAS scores,nursing compliance and pelvic floor recovery were compared between the two groups before and after nursing.Results The scores of SDS and SAS in the two groups were lower than those before nursing,the scores of SDS and SAS in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).The nursing compliance rate of the study group was higher than that of the control group,the difference was statistically significant(P＜0.05).69 cases(93.24%)of parturients in the observation group recovered their pelvic floor muscle strength to more than level 3,higher than 60 cases(81.08%)in the reference group,and the difference was statistically significant(P＜0.05).Conclusion Nursing intervention for primiparous women can effectively improve the psychological status of the mothers and is conducive to obtaining higher compliance during the period of receiving pelvic floor rehabilitation nursing.
2018 Vol. 25 (14): 161-163 [Abstract] ( 127 ) HTML (34 KB)  PDF  (0 KB)  ( 31 )
164 Application of comfort nursing in perioperative nursing of pulmonary lobectomy
Wang Yu-qian
Objective To observe the effect of comfortable nursing in the whole operation of thoracic surgery.Methods From July 2015 to July 2017,86 patients with pulmonary lobectomy were selected and divided into control group and experimental group according to the nursing methods selected by the patients,43 cases in each group.The patients in the control group were given whole-course nursing in the operating room,while the patients in the experimental group were given comfortable nursing on the basis of nursing in the control group.The anxiety and nursing coordination degree before and after nursing were compared between the two groups.Results Before nursing,there was no significant difference in HAMA score between the two groups(P＞0.05).The HAMA score of the two groups after nursing were significantly lower than that before nursing,the differences were statistically significant(P＜0.05).HAMA score in the experimental group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The degree of nursing cooperation in the experimental group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).Conclusion In the whole operation of thoracic surgery,comfortable nursing can effectively relieve the anxiety of patients and improve the nursing coordination so as to enhance the nursing effect,which is helpful to the patients′treatment and recovery.It is worth to be popularized in clinical practice.
2018 Vol. 25 (14): 164-166 [Abstract] ( 140 ) HTML (33 KB)  PDF  (0 KB)  ( 27 )
167 Application of fast track surgery concept combining with special traditional Chinese medicine nursing for lung cancer patients in perioperative period
FAN Min； GOU Yun； CAI Xiao-min
Objective To explore the clinical effect of fast track surgery(FTS)combining with special traditional Chinese medicine (TCM)nursing for lung cancer patients in perioperative period.Methods Eighty-eight patients with lung cancer who underwent video-assisted thoracoscopic surgery in our hospital from May 2017 to January 2018 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 44 cases in each group.The control group was given fast surgical rehabilitation nursing,while the observation group was given fast surgical rehabilitation nursing combined with special traditional Chinese medicine nursing.The postoperative recovery and complications of the two groups were compared.Meanwhile,the pain degree of the two groups was compared by visual analogue scale(VAS).Result The incidence of postoperative complications in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The postoperative extubation time,exhaust time,bed time,hospitalization time and antibiotics application time in the observation group were significantly shorter than those in the control group,the VAS score in the observation group was significantly lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion Application of FTS nursing combining with special TCM nursing for lung cancer patients in perioperative period can reduce postoperative complication occurrence rate and shorten hospital stays,thus it is worthwhile to popularize such combining nursing among lung cancer patients.
2018 Vol. 25 (14): 167-169 [Abstract] ( 135 ) HTML (32 KB)  PDF  (0 KB)  ( 22 )
170 Quality feedback loop model on the nursing quality and the family member satisfaction of patients with psychosis
NONG Qiu-yan； XIE Jian-fen ；DU Shu-hua
Objective To study the quality feedback loop model on the nursing quality and the family member satisfaction of patients with psychosis.Methods A total of 76 psychiatric patients were selected from March 2015 to January 2017 in our hospital.They were randomly divided into routine group and circulating quality group,with 38 cases in each group.The nursing mode of routine group was routine nursing mode,and the nursing mode of circulatory quality group was circulatory quality feedback mode.Family satisfaction was compared between the two groups.Disease cognitive level,treatment compliance;difference of quality of life score and BPRS scale score between pre-and post-care of patients in the two groups were compared.Results The family satisfaction of patients in the circulatory quality group was higher than that in the conventional group,and the difference was statistically significant(P＜0.05).Before nursing,there was no significant difference in quality of life score and BPRS scale score between the two groups(P＞0.05).After nursing,the scores of quality of life and BPRS scale in circulatory quality group were better than those in routine group,the differences were statistically significant(P＜0.05).The cognitive level of disease and the compliance of treatment in circulatory quality group were higher than those in routine group,the differences were statistically significant(P＜0.05).Conclusion The quality feedback loop model for psychiatric patients nursing quality is high,which can effectively improve the level of disease in patients with cognitive treatment adherence,and improve the patients'mental state and quality of life,promote family satisfaction enhancement,is worth promoting.
2018 Vol. 25 (14): 170-172 [Abstract] ( 143 ) HTML (33 KB)  PDF  (0 KB)  ( 29 )
173 The effect of auricular point buried bean combined with acupoint massage in vertigo
LIANG Dou-xuan
Objective To investigate the effect of auricular point buried bean combined with acupoint massage in vertigo.Methods A total of 174 patients with vertigo(yin deficiency and yang hyperactivity syndrome)in our hospital from January 2015 to December 2016 were randomly divided into control group and observation group,with 87 cases in each group.The control group was treated with routine therapy and emotional nursing,while the observation group was treated with auricular point embedding combined with acupoint massage on the basis of the control group,and 2 weeks were a course of treatment.Results The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).There was no significant difference between the two groups before the intervention(P＞0.05).After the intervention,the systolic and diastolic pressure of the observation group were significantly lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Buried beans with auricular points combined with acupoint massage in the treatment of vertigo patients with yin-deficiency and yang-hyperactivity syndrome has better effects,easier operation,easier acceptance and less toxic,and is worth using in clinical practice.
2018 Vol. 25 (14): 173-175转179 [Abstract] ( 129 ) HTML (35 KB)  PDF  (0 KB)  ( 27 )
176 Preventive effect analysis of"three prevention and three position"targeted nursing on prosthesis dislocation of patients with artificial hip joint replacement
TIAN Gui-xiang
Objective To study the preventive effect of “three prevention and three position” targeted nursing on prosthesis dislocation of patients with artificial hip joint replacement(AHJR).Methods A total of 414 AHJR patients admitted to our hospital from June 2014 to December 2015 were selected as the control group and given routine care.A total of 428 AHJR patients admitted to our hospital from January 2016 to July 2017 were selected as the observation group,based on the conventional nursing,"three-prevention and three-prevention"targeted nursing was given.The incidence of endoprosthesis dislocation within 3 months after surgery,anxiety and depression before and after nursing,and quality of life before and after nursing were compared between the two groups.Results The incidence of prosthesis dislocation within 3 months after surgery in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).There was no statistically significant difference in the incidence of femoral neck fracture,femoral head necrosis and congenital hip joint disease between the two groups(P＞0.05).There was no significant difference in SAS and SDS scores between the two groups before nursing (P＞0.05).SAS and SDS scores of the two groups after nursing were significantly lower than those before nursing,and those in the observation group were lower than that of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in SF-36 scores between the two groups before nursing(P＞0.05).The SF-36 scores of the two groups were significantly higher after nursing than before nursing,the differences were statistically significant(P＜0.05),and those in the observation group were higher than the control group,the differences were statistically significant(P＜0.05).Conclusion The“three prevention and three position” targeted nursing has a significant preventive effect on prosthetic dislocation of AHJR,which is beneficial to relieve anxiety and depression of patients,and effectively improve patients satisfaction and quality of life,so it is worthy of clinical application.
2018 Vol. 25 (14): 176-179 [Abstract] ( 135 ) HTML (36 KB)  PDF  (0 KB)  ( 29 )
180 Comparison of the effects of interactive health education and one-way education in the nursing care of children patients with fractures
LU Wen-hui；HAO Yu-tian
Objective To compare the effects of interactive health education and one-way education in the nursing care of children patients with fractures.Methods From July 2015 to October 2016,120 cases of pediatric fracture patients in our hospital were randomly divided into control group and observation group,60 cases in each group.Patients in the control group were given one-way education,while patients in the observation group were given interactive health education,and related clinical index data of patients in the two groups were observed and recorded.Results The hospitalization time in the observation group was significantly shorter than that in the control group,and the hospitalization expenses in the observation group was significantly lower than that in the control group,the differences were statistically significant(P＜0.05).The health knowledge of parents,parents were significantly higher than that of the control group,the differences were statistically significant(P＜0.05).The proportion of active functional exercise in the observation group was significantly higher than that in the control group,the coordination degree of functional exercise was significantly higher in children than in control group,the differences were statistically significant(P＜0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The satisfaction degree of parents in the observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Interactive health education has a significant effect in the nursing care of children patients with fractures,which can effectively shorten the length of stay and reduce hospitalization costs,and shows clear advantages in improving relevant health knowledge for the parents and promoting children′s initiative and compliance.Therefore,it is worthy of promotion and application in clinical practice.
2018 Vol. 25 (14): 180-182 [Abstract] ( 134 ) HTML (34 KB)  PDF  (0 KB)  ( 30 )
183 The application effect of detail nursing care in operating room
LIN Ze-hua； PENG Jian-you
Objective To study the application effect of detail nursing care in operating room.Methods From January to November 2017,110 patients who needed surgery were selected as the research object,and randomly divided into control group and observation group,55 cases in each group.The control group was given routine nursing in the operating room,while the observation group was given detailed nursing on the basis of routine nursing in operating room and the nursing quality scores and patient satisfaction of the two groups were observed and compared.Results The nurses′mastery rate of patients′illness,qualified rate of basic nursing,health education and propaganda rate and satisfaction rate of nursing quality in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05).The total satisfaction of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion The effect of detailed nursing care in operating room care is better,and the nursing quality score and patient satisfaction can be significantly improved,thereby improving the compliance of nursing care and ensuring the smooth operation.
2018 Vol. 25 (14): 183-185 [Abstract] ( 143 ) HTML (35 KB)  PDF  (0 KB)  ( 27 )
186 Effect of evidence-based nursing intervention on postoperative complications and sleep quality in snoring patients performed with surgeries
HUANG Hui-ni
Objective To study the clinical value of evidence-based nursing intervention in snoring patients during surgical treatment.Methods From November 2015 to November 2017,22 patients with snoring were randomly divided into control group and observation group,11 cases in each group.The control group received routine surgical nursing.Evidence-based nursing intervention was carried out in the observation group.The number of complications after the operation,sleep quality score and quality of life score were compared between the two groups before and after the operation,the satisfaction of clinical nursing during the operation treatment of snoring,and the total length of hospital treatment were compared between two groups.Results There was statistically significant difference in postoperative complications between the two groups(χ2=4.03,P＜0.05).The improvement of sleep quality score and quality of life score in the observation group was greater than that in the control group before and after operation(P＜0.05).The satisfaction of clinical nursing in the observation group was higher than that in the control group(P＜0.05).The satisfaction of clinical nursing in the observation group was higher than that in the control group(P＜0.05).The total length of postoperative hospitalization in the control group was(8.46±0.67)d,which was longer than that in the observation group(6.11±0.58)d,the difference was statistically significant(t=11.2974,P＜0.05).Conclusion Snoring patients with evidence-based nursing intervention during surgical treatment can significantly improve their sleep quality and quality of life,reduce postoperative complications,shorten postoperative recovery and treatment time,and thus increase the total therapeutic effectiveness rate.
2018 Vol. 25 (14): 186-188 [Abstract] ( 129 ) HTML (34 KB)  PDF  (0 KB)  ( 29 )
189 Analysis of the factors of pulmonary infection after tracheotomy in patients with traumatic brain injury and the nursing countermeasures
WU Min；LIU Hui-ling；XU Xiao-hong
Objective To explore the risk factors of pulmonary infection after tracheotomy in patients with traumatic brain injury,and to evaluate the application value of targeted nursing intervention in patients with pulmonary infection.Methods 80 cases of tracheotomy patients with brain trauma admitted to our hospital from February 2015 to May 2017 were selected as the research objects,and the clinical data such as Glasgow(GCS)score,albumin,tracheotomy time,medical history of pulmonary infection patients(n=27)and non-infection patients(n=53)were analyzed and compared emphatically.The targeted nursing intervention was used in the patients with pulmonary infection,and the normal nursing methods were used in non infected patients,to compared the nursing satisfaction of the two groups.Results The results of univariate analysis showed that there were statistically significant differences in smoking history,diabetes history,gastric tube indwelling,combined injuries,prophylactic use of antibiotics,application of hormones,GCS score,tracheotomy time and albumin level between infected and non-infected groups (P＜0.05).Multivariate Logistic regression analysis showed that the independent risk factors of lung infection after tracheotomy in patients with brain trauma were the longer time of tracheotomy,the lower GCS score,the history of hormone use and diabetes mellitus (P＜0.05).There was no statistically significant difference in smoking history,gastric tube indwelling,combined injuries,prophylactic application of antibiotics and albumin levels(P＞0.05).The total satisfaction of patients in the infected group was lower than that in the non-infected group,but there was no significant difference (χ2=0.200,P＞0.05).Conclusion There are many factors affecting pulmonary infection after tracheotomy patients with traumatic brain injury,including hormone and antibiotics application history,diabetes history and tracheotomy time are the main influence factors,the clinical impact of these factors to give corresponding nursing measures for the prevention of pulmonary infection and has a positive significance to improve patient satisfaction.
2018 Vol. 25 (14): 189-191转194 [Abstract] ( 179 ) HTML (34 KB)  PDF  (0 KB)  ( 27 )
192 Application effect of blood-letting therapy combined with external-application of Chinese herbs in clinical nursing of gout arthritis
LI You-e ；NIE Yan-yan ；XU Qing-lian ；TANG Jing-feng
Objective To explore and analyze the clinical nursing effect and significance of blood-letting therapy combined with external-application of Chinese herbs on gout arthritis.Methods A total of 80 gouty arthritis patients were selected from April 2016 to April 2017 in our hospital.They were divided into control group and observation group by random number table method,40 cases in each group.The control group was treated by conventional nursing method,and the observation group was treated by external application of puncture bloodletting traditional Chinese medicine on the basis of the control group method.The effect of the two groups after nursing was compared.Results There was no significant difference in pain score between the two groups before nursing(P＞0.05).The pain score in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).The nursing satisfaction of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion The combination of blood-letting therapy and external-application of traditional Chinese herbs can significantly improve the clinical efficacy in patients with acute gouty arthritis.The reliability,safety,and patient satisfaction on nursing are all relatively higher compared with the conventional mode,which is worthy of application and promotion.
2018 Vol. 25 (14): 192-194 [Abstract] ( 148 ) HTML (31 KB)  PDF  (0 KB)  ( 32 )
195 Application of comprehensive nursing in the elderly aerosolized Budesonide combined with Terbutaline Sulfate Aerosol inhalation therapy
DENG Zhi-fang
Objective To investigate the effect of Budesonide combined with Terbutaline Sulfate inhalation therapy for elderly patients with chronic obstructive pulmonary disease.Methods Fifty elderly patients with chronic obstructive pulmonary disease were selected from July to December 2017.According to the treatment methods,they were divided into control group and observation group,25 cases in each group.All patients were given Budesonide combined with Terbutaline Sulfate Aerosol inhalation therapy,the control group was given ordinary care,the observation group was given comprehensive care.The clinical efficacy of COPD in two groups was compared.Average hospital stay,awareness of COPD etiology,knowledge of medication,compliance behavior score were compared.The pulmonary function indexes FEV1,FVC and FEV1/FVC of patients before and after treatment were compared.Adverse drug reaction rate was also compared.Results The clinical efficacy of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Before treatment,there was no significant difference in pulmonary function between the two groups(P＞0.05).The pulmonary function indexes of FEV1,FVC and FEV1/FVC of the two groups after treatment were significantly better than those before treatment(P＜0.05).After treatment,the pulmonary function indexes of FEV1,FVC and FEV1/FVC in the observation group were better than those in the control group,the differences were statistically significant(P＜0.05).The average length of hospital stay in the observation group was shorter than that in the control group,the awareness of COPD etiology,knowledge of medication and compliance behavior were higher in the observation group than in the control group (P＜0.05).The incidence of adverse reactions in the observation group was lower than those in the control group,the difference was statistically significant(P＜0.05).Conclusion The inhalation of Budesonide and Terbutaline Sulfate for the treatment of COPD in the elderly is effective.Supplemented by comprehensive care,it can improve the patient′s disease,medication awareness and compliance behavior,effectively control the condition,relieve bad mood and improve lung Functional and quality of life,reducing adverse drug events,it is worth promoting.
2018 Vol. 25 (14): 195-197 [Abstract] ( 148 ) HTML (37 KB)  PDF  (0 KB)  ( 32 )
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