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| Effect of Prunella vulgaris Decoction combined with Nifedipine in the treatment of primary hypertension |
| LIN Yuan-yuan XIONG Yi-tao▲ |
| Department of Pharmacy,Hubei Provincial Hospital of TCM,Wuhan 430074,China |
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Abstract Objective To investigate the effect of Prunella vulgaris Decoction combined with Nifedipine in the treatment of primary hypertension.Methods From March 2011 to September 2016,90 patients with primary hypertension treated in our hospital were selected as the subjects,and divided into the observation group and the control group randomly,45 cases in each group.The control group was treated with Nifedipine 20 mg each time,1 times in the morning and evening.The observation group was treated with mixed Decoction of Prunella vulgaris 200 ml,1 times in the morning and evening on the basis of the treatment of the control group,and treatment continued for 120 days.The blood pressure and the pulse pressure before and after treatment in patients were detected.The nitric oxide (NO)and endothelin-1(ET-1)were detected with radioimmunoassay.The content of vascular angiotensinⅡ (AngⅡ),norepinephrine epinephrine(NE)and soluble vascular cell adhesion molecule 1(sVCAM-1)were detected with ELISA.Results The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).After the treatment,the content of NO in the two groups increased significantly (P＜0.05).The blood pressure,pulse pressure,ET-1,AngⅡ,sVCAM-1 and NE after the treatment were lower than before treatment,the difference was statistically significant(P＜0.05).After the treatment,the content of NO in the observation group was higher than that in the control group (P＜0.05).The levels of blood pressure,pulse pressure,ET-1,AngⅡ,sVCAM-1 and NE in the observation group were significantly lower than those in the control group(P＜0.05).Conclusion Prunella vulgaris Decoction combined with Nifedipine can significantly reduce the blood pressure and pulse pressure in patients with primary hypertension,effectively improve the vascular function of patients,and can achieve better therapeutic effect.
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