2016～2017年湛江市第一中医医院慢性阻塞性肺疾病急性加重期患者呼吸道病原菌分布及耐药性分析

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Abstract Objective To analyze the distribution and drug resistance of respiratory pathogens bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease in the the First Hospital of Traditional Chinese Medicine in Zhanjiang City from January 2016 to December 2017,so as to provide guidance for rational use of antibiotics in clinic.Methods A total of 300 patients with acute exacerbation of chronic obstructive pulmonary disease from January 2016 to December 2017 in the the First Hospital of Traditional Chinese Medicine in Zhanjiang City were checked and analyzed for respiratory tract pathogen detection and bacterial susceptibility test results,and the distribution and drug resistance of pathogenic bacteria were obtained by retrospective analysis.Results Of the 300 samples,326 strains were detected,of which 126 were Gram-positive bacteria,account for 38.66%,182 strains of Gram-negative bacteria,accounting for 55.82%,18 strains of Fungi,accounting for 5.52%.The resistance rates of Staphylococcus aureus to Penicillin,Oxacillin were higher than 50%,while no drug resistance to Vancomycin and Teicoplanin was demonstrated.The resistance rates of Staphylococcus epidermidis to Penicillin,Oxacillin,Cefazolin,Ceftazidime and Cefoxitin were higher than 50%,however,it showed a low resistance rate for Gentamicin,Vancomycin and Teicoplanin.The resistance rates of Pseudomonas aeruginosa to Piperacillin,Amikacin,Gentamycin,Ciprofloxacin and Levofloxacin were higher than 20%,and the resistance rate to Imipenem were low.The resistance rate of Escherichia coli to Piperacillin,Amikacin,Gentamicin,Ciprofloxacin,Levofloxacin and Imipenem were higher than 20%.Conclusions The pathogenic bacteria of respiratory tract were mainly Gram-negative bacteria in the acute exacerbation period of chronic obstructive pulmonary disease in our hospital from from January 2016 to December 2017.The rate of drug resistance is high.In clinical practice,rational antimicrobial agents should be selected in combination with drug sensitivity test results.Meanwhile,the drug resistance monitoring should be strengthened to improve the clinical therapeutic effect.

Key words： Chronic obstructive pulmonary disease Acute exacerbation period Pathogenic bacteria Drug resistance

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	Articles by authors
	ZHENG Li-ming
	LIU Hua-zhen
	CHEN Zhan

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ZHENG Li-ming,LIU Hua-zhen,CHEN Zhan. Distribution and drug resistance of respiratory pathogenic bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease in the First Hospital of Traditional Chinese Medicine in Zhanjiang City from 2016 to 2017[J]. 中国当代医药, 2018, 25(14): 135-138.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I14/135

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