2型糖尿病患者血浆同型半胱氨酸水平及相关因素分析

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Abstract Objective To investigate the level of plasma homocysteine(Hcy)and its related factors in patients with type 2 diabetes.Methods A total of 150 patients with type 2 diabetes treated in our hospital from August 2016 to October 2017 were selected as type 2 diabetes group,and 60 healthy persons underwent physical examination in the same period were selected as the control group.The patients in type 2 diabetes group were divided into two groups according to whether Hcy was greater than 15 μmol/L,for the high Hcy group(n=62,Hcy＞15 μmol/L)and the normal Hcy group(n=88,Hcy≤15 μmol/L).The difference of Hcy,body measurement,plasma glucose,insulin,serum creatinine,blood lipid and uric acid were compared between the two groups.The influencing factors of plasma Hcy level in patients with type 2 diabetes were analyzed by multivariate Logistic regression analysis.Results The BMI,uric acid,Hcy,FPG,2 h PG,HOMAIR and creatinine in type 2 diabetes group were higher than those in the control group,the differences were statistically significant(P＜0.05).The male proportion,age,uric acid,HOMA-IR and creatinine levels of the patients in the high Hcy group were significantly higher than those in the normal Hcy group,and the differences were statistically significant(P＜0.05).Logistic regression analysis showed that in patients with type 2 diabetes,male,blood uric acid and HOMA-IR were risk factors for high Hcy hyperlipidemia(P＜0.05).Conclusion Plasma Hcy level in patients with type 2 diabetes is significantly higher than healthy person.Male,blood uric acid and insulin resistance are risk factors for high Hcy hyperlipidemia in patients with type 2 diabetes.

Key words： Type 2 diabetes Homocysteine Realated factors analysis

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	Articles by authors
	LIU Xiang-ru
	LI Yue
	YANG Bin
	FENG Yao-ran
	LIANG Yong-qian

Cite this article:

LIU Xiang-ru,LI Yue,YANG Bin, et al. Analysis of plasma homocysteine level and related factors in patients with type 2 diabetes[J]. 中国当代医药, 2018, 25(14): 57-59.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I14/57

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