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Influence of preoperative injection of different vasoactive drugs on the maternal and neonatal during the spinal-epidural anesthesia of cesarean section in severe pre-eclampsia patients |
ZHANG Jia-ze ZHANG Xiao |
Yangchun Maternity and Child Care Hospital,Guangdong Province,Yangchun 529600,China |
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Abstract Objective To study the influence of preoperative injection of different vasoactive drugs on the maternal and neonatal during the spinal-epidural anesthesia of cesarean section in severe pre-eclampsia patients.Methods From December 2016 to December 2017,60 severe pre-eclampsia patients undergoing the spinal-epidural anesthesia in our hospital were selected as the subjects,and divided to three groups by radom digital table method,20 cases in each group.Group A took the pumping injection of ephedrine (2 mg/min).Group B took the pumping injection of norepinephrine(25 ug/min).Group C took the equivalent normal saline.The final outcomes were observed.Results At 1,10,12 and 15 min,there was no significant difference in the blood pressure among three groups(P>0.05).At 3,5 and 7 min,the blood pressure in Group C was significantly lower than that in Group A and Group B (P<0.05).At 1 min,there was no significant difference in the heart rate among three groups(P>0.05).At 3,5,7,10,12 and 15 min,the heart rate in Group C was significantly higher than that in Group A and Group B,the difference was statistically significant(P<0.05).After 5 min,the heart rate in Group B was significantly higher than that in Group A,the difference was statistically significant(P<0.05).There were no significant a difference in the lactic acid,PCO2,PO2,BE and pH among three groups (P>0.05).The incidence rate of nausea and vomiting in Group A and Group B was lower than that in Group C,the difference was statistically significant(P<0.05).Conclusion During the spinal-epidural anesthesia of cesarean section,the preoperative injection of Ephedrine and Norepinephrine can maintain the hemodynamics stability,keep the blood concentration and improve the maternal and neonatal prognosis.
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[1] |
李桂英.腰硬联合麻醉在重度子痫前期剖宫产手术中的应用研究[J].现代中西医结合杂志,2015,24(26):2957-2959.
|
[2] |
阮晓黎,张伟锋.先兆子痫与子痫患者在剖宫产术中的麻醉处理与急救措施[J].中国妇幼健康研究,2016,27(12):1531-1533.
|
[3] |
黎荣福,费宏亮,胡振伐,等.不同诱导方法用于子痫剖宫产术的安全性比较[J].中国妇幼健康研究,2015,26(6):1245-1248.
|
[4] |
肖飞,徐文平,刘林,等.混合舒芬太尼时布比卡因用于剖宫产术重度子痫前期患者蛛网膜下腔阻滞的量效关系[J].中华麻醉学杂志,2016,36(11):1316-1318.
|
[5] |
Narasimhulu DM,Karakash S,Rankin L,et al.Resolution of superimposed pre-eclampsia,and improvement in umbilical artery flow in a surviving twin after intrauterine demise of its co-twin[J].J Obstet Gynaecol Res,2015,41(9):1473-1477.
|
[6] |
贺晶,闫雪.腰硬联合麻醉与硬膜外麻醉对重度子痫前期剖宫产产妇血流动力学和新生儿Apgar评分的影响[J].中国实验诊断学,2016,20(10):1709-1712.
|
[7] |
肖飞,徐文平,张望平,等.重度子痫前期产妇剖宫产布比卡因蛛网膜下腔阻滞麻醉适合剂量的临床研究[J].浙江医学,2015,37(4):321-323,332.
|
[8] |
施秀亚,胡华敏,封英,等.腰硬联合麻醉下剖宫产对重度子痫前期患者血流动力学的影响[J].中华全科医学,2016,14(12):2067-2069.
|
[9] |
陈秀斌,刘志强.蛛网膜下腔阻滞联合硬脊膜外腔阻滞麻醉用于子痫前期患者的安全性[J].上海医学,2012,35(8):663-667.
|
[10] |
汪辉,陈金保.鞘内注射右美托咪定对子痫前期剖宫产产妇麻醉效果及新生儿的影响[J].中国妇幼保健,2017,32(18):4575-4577.
|
[11] |
肖玮,段庆芳,福文雅,等.目标导向液体治疗对子痫前期孕产妇行腰麻剖宫产手术中血流动力学的影响[J].北京医学,2015,37(8):731-735.
|
[12] |
张秀海,尔丽绵.腰硬联合麻醉在重度子痫前期孕妇行剖宫产术的安全应用分析[J].中国临床医生杂志,2015,43(9):69-71.
|
[13] |
李应龙,付婷,张宏,等.硬膜外麻醉和硬腰联合麻醉用于重度子痫前期患者剖宫产手术的比较[J].陕西医学杂志,2011,40(10):1395-1396.
|
[14] |
白延斌,刘磊,胡彬,等.腰硬联合麻醉后母体血流动力学及脐动脉血流的变化研究[J].实用临床医药杂志,2015,19(19):183-185.
|
[15] |
蔡恒宇,郜红艳.预注不同血管活性药对重度子痫前期患者腰硬联合麻醉剖宫产母儿的影响[J].实用药物与临床,2014,17(10):1258-1261.
|
|
|
|