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2017 Vol. 24, No. 17
Published: 2017-06-18
 
 
4 Effect of cordycepin on p38MAPK pathway and TGF-β1express in NRK52E cells stimulated by high glucose
LIANG Ze-zhi;HUANG Jie-ping
ObjectiveTo investigate effect of cordycepin on p38MAPK pathway and TGF-β1express in NRK52E cells stimulated by high glucose.MethodsNRK52E cells were cultured in the mediun with normal glucose concentration（group NG）,high glucose concentration（group HG）and high glucose concentration+cordycepin（group HG+C）.The expression of p38MAPK and TGF-β1mRNA was measured by quantitative RT-PCR;the expression level of p-p38MAPK and TGF-β1protein was detected by Western blot.ResultsThe p38MAPK and TGF-β1mRNA in NRK52E cells were highly expressed in group HGcompared with group NG（P＜0.01）;the tendency of p-p38MAPK and TGF-β1protein expressed was accordance with expression of mRNA.However,cordycepin can significantly inhibit the activation of p38MAPK pathway and TGF-β1express in NRK52E cells stimulated by high glucose.ConclusionCordycepin can significantly inhibit the activation of p38MAPK pathway and TGF-β1express in NRK52E cells stimulated by high glucose.
2017 Vol. 24 (17): 4-7 [Abstract] ( 138 ) HTML (48 KB)  PDF  (0 KB)  ( 35 )
8 Efficacy of Simvastatin on the expression of APP and BACE in rats with hypercholesterolemia
LIANG Qian TANG Wei LIU Wen-bo WANG Wei
ObjectiveTo explore the efficacy of Simvastatin on the expression of APP and BACE in rats with hypercholesterolemia,providing theoretical basis for the prevention and treatment in Alzheimer′s Disease.MethodsThe 32 rats used in this experiment were 3 months old and randomly divided into normal diet group(n=16)and high cholesterol diet groups(n=16).The high diet groups were randomly divided into high lipid feed the placebo group(n=8)and high-fat feed drug group(n=8).And then medicine was filled into their stomach:the high fat diet drugs group were given simvastatin 2 mg/（kg·d）,the high fat diet placebo group placebo(distilled water)by the same volume,the high fat forage during lavage.Normal feed group were randomly divided into normal feed placebo group and normal feed drug group,respectively to the same volume with the placebo(distilled water)and simvastatin 2 mg/（kg·d）to fill the stomach,the normal fat forage during lavage,with behavior evaluation after 8 weeks.Immune histochemical method to determine the brain′s protein expression with APP,BACE.ResultsThe result of APP,BACE protein expression in the prefrontal cortex and the hippocampus with immunohistochemical detection:the protein expression of APP and BACE in the prefrontal cortexis and the hippocampus was decreased in high fat feed drug group than the normal feed placebo group(P＜0.05),there was no significant difference in the normal feed placebo group,the normal feed drug group and the high fat feed drug group (P＞0.05).ConclusionSimvastatin may affect the protein expression of APP,BACE in the prefrontal cortex and the hippocampus by the hypercholesterolemia rats,which have an impact on the metabolism of Aβ1-42.
2017 Vol. 24 (17): 8-11转26 [Abstract] ( 173 ) HTML (53 KB)  PDF  (0 KB)  ( 38 )
12 Research progress of TGF-β and organ fibrosis
ZUO Kui-yang;CHEN Meng-xi;MENG Na-na;JIN Xiu-dong;LIU Hai-feng
Transforming growth factor-β(TGF-β)is a kind of growth factor which turn normal cellular into fibrosis,and it plays an important role in the process of renal tubule interstitial fibrosis.TGF-β has the characters that widely spreading and influence.There are 4 sub-types has been found at least in mammals and it could be produce by varieties of cell in human.It contains 2 signaling pathways that Smad and MAPK,and the critical functions are cell growth depression and enhancing the gathering of extracellular matrix.One of the reasons cause chronic renal failure is excessive ECM deposition when renal tubule switch to fibrosis.Renal interstitial fibrosis is the common pathway of various development of kidney disease to kidney failure and the pathologic basis of persistent liver damage can lead to liver fibrosis and cirrhosis caused by large area.The renal interstitial fibrosis and hepatic fibrosis,TGF-beta also played a very important role.This paper aims at about TGF-beta function,TGF-beta receptor signal transduction pathway and renal tubule fibrosis and liver fibrosis related quality progress were discussed,and the TGF-beta receptor in clinical application are briefly discussed.
2017 Vol. 24 (17): 12-16 [Abstract] ( 154 ) HTML (63 KB)  PDF  (0 KB)  ( 55 )
17 Research progress on the treatment efficacy of Echinacoside
CHEN Nai-jie
Echinacoside is a potent medicinal component with pharmacological effects of antioxidant,anti-inflammatory, neuroprotective,improving learning and memory,anti-tumor,liver protection and so on.Therefore,it can be used for the treatment of multiple diseases.The further exploration and development of the mechanism is of great significance.Referred to relevant literatures in recent years on echinacoside,this paper reviews its therapeutic effect in order to provide a reference for in-depth research on the herb.
2017 Vol. 24 (17): 17-19 [Abstract] ( 168 ) HTML (42 KB)  PDF  (0 KB)  ( 74 )
20 Analysis of influence factors of seasonal blood pressure change in patients with maintenance hemodialysis under the comprehensive therapy intervention
NI Xi-zhi PENG Xin DENG You-you RAO Qi
ObjectiveTo explore the influence factors of the seasonal blood pressure change in patients hypertension given with maintenance hemodialysis under the comprehensive therapy intervention to provide evidence for clinical treatment for the patients.MethodsA total of 60 patients with maintenance hemodialysis treated in outpatient of People′s Hospital of Baoan District in Shenzhen City and Fuyong People′s Hospital of Baoan District in Shenzhen City and this patients were given comprehensive therapy intervention at the same time from January 2015 to June 2016 were selected.The patients were given home blood pressure monitoring,individualized antihypertensive treatment,medication compliance education,sleep quality survey,volume control education,dietary sodium intake and telephone following-up, and ntihypertensive drugs and erythropoietin (EPO)use,blood pressure value,the growth rate of body weight during dialysis period,hemoglobin,creatinine,urea nitrogen and other results in summer(6-8 months)and winter(12-next year of 2 months)in patients were collected,and the above-mentioned indexes between the two groups were compared.ResultsAfter comprehensive treatment,the systolic pressure for patients in summer and winter was(137.7±12.31)mmHg and (143.5±14.78)mmHg respectively,and the diastolic blood pressure was (83.52±10.75)mmHg and (87.2±11.31) mmHg respectively before dialysis,and the differences were statistically significant(P＜0.05).There were no significant differences in the test results of creatinine and urea nitrogen between summer and winter(P＞0.05).Multiple linear regression analysis showed that IDWG(P=0.024),EPO treatment(P=0.027)and sleep time difference(P=0.038)were the influencing factors of seasonal change in blood pressure.ConclusionThe occurrence of elevated blood pressure is influenced by many factors in winter,amog them,IDWG is the main factors affecting winter elevated blood pressure,and being treated with EPO and sleep quality are related influence factors,only the comprehensive treatment and intervention applied in patients with hypertension given with maintenance hemodialysis then the effective treatment plan is put forward for the control the seasonal hypertension.
2017 Vol. 24 (17): 20-23转53 [Abstract] ( 150 ) HTML (50 KB)  PDF  (0 KB)  ( 64 )
24 Guidance value of thrombelastogram and conventional coagulation index in infusion of blood products for patients with DIC
ZENG Long-hong;QI Miao-hua;HU Xiao-jing
ObjectiveTo explore the guidance value of thrombelastogram and routine coagulation index in the infusion of blood products in patients with diffuse intravascular coagulation(DIC).Methods58 cases with DIC treated in our hospital and treated by infusing the blood products from February 2016 to January 2017 were selected as objects.The patients were randomly divided into group A (29 cases)and group B (29 cases)adopting the computer extraction inpatient number method.Group A was given thrombelastogram guidance,while group B were given the routine coagulation index. Transfusion volume of plasma,platelet,cold precipitation and curative effect was compared between the two groups.ResultsTransfusion volume of plasma,platelet,cold precipitation in 24 hours in group A were less those of group B[(1238.4± 356.1)ml vs.(1812.5±468.5)ml,(36.2±5.8)U vs.(44.9±7.6)U,(29.6±6.6)U vs.(39.4±5.8)U](P＜0.05).The treatment effect of group A was significantly higher than that of group B (89.66%vs.62.07%)(P＜0.05).ConclusionThrombelastogram in DIC patients to guide the infusion of blood products has a better clinical efficacy compared with the conventional coagulation index.
2017 Vol. 24 (17): 24-26 [Abstract] ( 165 ) HTML (37 KB)  PDF  (0 KB)  ( 61 )
27 Application effect of Polyethylene glycol electrolyte powder combined with oral liquid of Lactulose on bowel preparation in aged patients with constipation by colonoscopy
JIANG Xiao-li;ZHONG Mai-wen;REN Bo;HE Hui-ping;MAI Bi-ru
ObjectiveTo explore the effect of Polyethylene glycol electrolytes powder combined with oral liquid of Lactulose on intestinal preparation in elderly patients with constipation by colonoscopy.MethodsA total of 150 aged patients performed with electronic colonoscope from May to December 2016 in our hospital were enrolled in this study. The patients were divided into Polyethylene glycol electrolyte powder group,Lactulose group and experimental group (Polyethylene glycol electrolyte powder combined with oral solution of Lactulose).The adverse reactions of bowel preparation among three groups were observed as well as the patient′s tolerance,the intestinal cleanliness via colonoscope was also observed.ResultsThe incidence of adverse reactions,bowel preparation within the specified time, tolerance of intestinal preparation,and cleanliness were all displayed statistical differences(P＜0.05).There was no statistical difference in the success rate of enteroscope reaching ileocecal valve(P＞0.05).ConclusionBowel preparation of Polyethylene glycol electrolyte powder combined with oral liquid of Lactulose for elderly patients with constipation can increase their compliance,which is safe and effective,and is considered as a favorable method.
2017 Vol. 24 (17): 27-29 [Abstract] ( 195 ) HTML (40 KB)  PDF  (0 KB)  ( 59 )
30 Study on the correlation between serum CRP,DD,BNP and adverse events in patients with acute pulmonary embolism
LENG Wen-wen;ZHANG Chao;ZHAO Xuan
ObjectiveTo investigate the clinical value of C reactive protein (CRP),D-dimer(DD)and brain natriuretic peptide(BNP)in the short-term prognosis of acute pulmonary embolism(PE).Methods30 cases treated in our respiration medicine from October 2014 to October 2016 of acute pulmonary embolism patients were divided into high concentration group(DD＞5000 ns／ml,CRP＞10 mg/L,BNP＞500 ng/L)and low concentration group(DD＜4999 ns/ml,CRP＜10 mg/L,BNP＜500 ng/L),15 cases in each group.The adverse eventin the two groups was recorded and analyzed during treatment and after 3 months.Logistic linear regression analysis was used to analyze the correlation between the concentration of CRP,DD,BNP and adverse event.ResultsThe number of deaths within 3 months in the high concentration group was significantly higher than that of the low concentration group,the difference was statistically significant(P＜0.05);The concentration of CRP,BNP in dead patients was significantly higher than those of the survived patients,the difference was statistically significant(P＜0.05).While the concentration of DD in two groups had no statistically difference（P＞0.05）.Logistic linear regression analysis showed that the concentration blood CRP,BNP,DD level before treated had a high correlation with death.ConclusionThe concentration of CRP,DD and BNP before treated has a high clinical value in the short-term prognosis of acute pulmonary embolism,and it is worth promoting.
2017 Vol. 24 (17): 30-32 [Abstract] ( 151 ) HTML (36 KB)  PDF  (0 KB)  ( 73 )
33 Clinical analysis of ERCP combined with LC in treatment of cholecystolithiasis with choledocholithiasis
RUAN Wei-shan;CEN Chuan;LIN Hong-kai;LIU Ye-lin
ObjectiveTo observe the clinical effect of ERCP combined with LC in the treatment of gallstones with choledocholithiasis.Methods100 patients with gallstones combined with choledocholithiasis (December 2013 to December 2016)were selected as our subjects.All patients were randomized to observaction group and the control group，including 50 patients in each group.LC+LCBDE in patients was given with laparoscopic cholecystectomy of control group ERCP+LC)was given in patients of observation group for treatment.The operative time，hospitalization time，hospitalization cost，stone clearance rate，operation success and the probability of occurrence of complication were compared between the two groups.ResultsThe operation time,hospitalization time and hospitalization cost of the patients with choledocholithiasis combined with choledocholithiasis were lower than those in the control group(P＜0.05).After treatment，the removal rate of stones was 94.00%，the success rate was 76.00%of the observation,and 80.00%,54.00%of the control group,P＜0.05.The probability of occurrence of complications in the observation group was 8.00%,which was lower than that in the control group(24.00%),P＜0.05.ConclusionERCP combined with LC in the treatment of gallstones with choledocholithiasis is more effective，high stone clearance rate，shorter hospital stay,and is widely popularized.
2017 Vol. 24 (17): 33-35 [Abstract] ( 150 ) HTML (36 KB)  PDF  (0 KB)  ( 61 )
36 Clinical effect of modified Fangfeng Tongsheng Powder in the treatment of facial allergic dermatitis with hormone-resistance and its influence on serum IgE level
YAO Dong-mei;LI Shu-lan
ObjectiveTo evaluate the clinical effect of modified Fangfeng Tongsheng Powder in the treatment of facial allergic dermatitis with hormone-resistance and its influence on serum IgE level.Methods80 patients with facial hormone-resistant atopic dermatitis treated in our hospital from March 2015 to January 2017 were selected and divided into control group and observation group according to the patients′wishes.Among them，patients in the control group(n= 38)were treated by conventional Western medicine therapy,and in the observation group(n=42),patients were provided with modified Fangfeng Tongsheng Powder besides therapy in the control group.The clinical effect and serum IgE level were compared in the two groups.ResultsThe total effective rate in the observation group was higher than that in the control group (χ2=4.06,P＜0.05).The levels of pro-inflammatory cytokines IL-6,TNF-α and IL-8 in the observation group were significantly decreased after therapy(P＜0.05).The level of serum IgE was also significantly decreased in the observation group(P＜0.05).The score of DIQI after therapy in the observation group was significantly lower than that in the control group (P＜0.05).ConclusionFor facial allergic dermatitis with hormone-resistance,combination of modified Fangfeng Tongsheng powder is better than conventional Western medicine therapy,which is worthy of clinical application and promotion.
2017 Vol. 24 (17): 36-38 [Abstract] ( 162 ) HTML (39 KB)  PDF  (0 KB)  ( 46 )
39 Effect analysis of laparoscopic retrograde subtotal cholecystectomy in the treatment of chronic calculous cholecystitis
XIE Shi-hua;LIU Zhi-wen;ZHOU Gao-sheng;GUO Chang-wen
ObjectiveTo discuss the clinical effect of laparoscopic retrograde subtotal cholecystectomy in the treatment of chronic calculous cholecystitis.Methods86 patients with chronic calculous cholecystitis treated in the hospital from March 2014 to March 2016 were enrolled and they were randomly divided into two groups,and there were 43 cases in each group.The control group was treated with laparoscopic total cholecystectomy,while the treatment group was treated with laparoscopic subtotal cholecystectomy.The treatment effect,bleeding volume,operation time,exhaust time,ambulation time,postoperative hospital stay were compared between the two groups.ResultsThe total effective rate in the treatment group was 90.7%,which was obviously higher than that of 69.8%in the control group (P＜0.05).The amount of bleeding in the treatment group was obviously less than that in the control group (P＜0.05),and the operation time,exhaust time, ambulation time,postoperative hospital stay of the treatment group were significantly shorter than those of the control group (P＜0.05).ConclusionThe laparoscopic retrograde subtotal cholecystectomy has a good effect in the treatment of chronic calculous cholecystitis.
2017 Vol. 24 (17): 39-41 [Abstract] ( 161 ) HTML (41 KB)  PDF  (0 KB)  ( 58 )
42 Clinical effect of invasive and non-invasive ventilation sequential therapy in patients with chronic obstructive pulmonary disease complicated with acute respiratory failure
HUANG Guan-yu;SU Ming;JIANG Yong;DENG Ming-han;DENG Jie;QIN Qiu-yi;HUANG Li
ObjectiveTo observe the clinical effect of invasive and non-invasive ventilation sequential therapy in patients with chronic obstructive pulmonary disease(COPD)complicated with acute respiratory failure.Methods78 cases with COPD complicated with acute respiratory failure treated in our hospital from January 2014 to October 2016 were selected and they were divided into the two groups according to the random number table method and there were 39 cases in each group.The patients in the control group were given the routine invasive ventilation treatment,while the patients in the observation group were given invasive and non-invasive ventilation sequential therapy.The clinical effect were compared between the two groups.ResultsThe duration of invasive ventilation,overall time of ventilation treatment and ICU stay time [(5.2±1.5),(11.8±2.4),(11±2)d respectively]in patients of observation group obviously were shorter than those of control group[(15.5±4.0),(14.0±5.0),(16±4)d](P＜0.05)and the re-intubation rate was 7.7%,the incidence of VAP was 5.1%in the patients of observation group were obviously lower than those of control group(25.6%,23.1%)(P＜0.05).ConclusionInvasive and non-invasive ventilation sequential therapy in patients with COPD complicated with acute respiratory failure is safe and effective,and it is worthy of promotion,in patients with chronic obstructive pulmonary disease in patients with acute respiratory failure in the application of noninvasive ventilator sequential treatment Treatment is safe and effective,worthy of promotion
2017 Vol. 24 (17): 42-44 [Abstract] ( 152 ) HTML (38 KB)  PDF  (0 KB)  ( 29 )
45 Correlation study of active vitamin D3and carotid atherosclerosis in patients with chronic kidney disease
LAI Yu-ping;ZHANG Zhou;LIANG Yan-juan;YOU Yong-sen
ObjectiveTo investigate the relationship between active vitamin D3,micro-inflammation and carotid atherosclerosis in patients with chronic kidney disease(CKD),and whether active vitamin D3 could improve carotid atherosclerosis and the possible mechanism.Methods96 non-dialysis patients diagnosed as CKD in our hospital from July 2014 to July 2015 were divided into three groups according to the glomerular filtration rate(GFR),group A was CKD3 stage,group B was CKD4 stage,group C was CKD5 stage,and each group had 32 cases.Each group was given Calcitriol of 0.25 μg/d for 1 year.25 hydroxyvitamin D3[25(OH)2D3],hypersensitivity C reactive protein(hs-CRP)and carotid intima-media thickness(IMT)before and after treatment in the three groups were measured.Results25(OH)2D3was decreased,hs-CRP increased and IMT decreased before treatment in the three groups which was associated with the progress of CKD,then after Calcitriol treatment,hs-CRP and IMT decreased (P＜0.05).The decrease degree of hs-CRP and IMT was positively correlated with the increase of 25(OH)2D3(P＜0.05).Conclusion5(OH)2D3level and micro-inflammatory status are the factors of carotid atherosclerosis in patients with CKD,Calcitriol can improve carotid atherosclerosis by improving the Micro inflammation.
2017 Vol. 24 (17): 45-47 [Abstract] ( 175 ) HTML (41 KB)  PDF  (0 KB)  ( 63 )
48 Relationship between HOMA-IR,HbA1c and hs-cTnT in patients with diabetic cardiomyopathy
LIN Jian
ObjectiveTo investigate the relationship between insulin resistance index(HOMA-IR),glycosylated hemoglobin (HbA1c)and high-sensitivity troponin T(hs-cTnT)in patients with diabetic cardiomyopathy.Methods100 patients with diabetic cardiomyopathy from January to October in 2016 in our hospital were selected as the diabetic cardiomyopathy group,100 patients with simple diabetes mellitus at the same time were enrolled as the simple diabetes mellitus group, the Pearson correlation analysis was used to analyzed the relationship between HOMA-IR,HbA1c and hs-cTnT,the level of HOMA-IR,HbA1c and hs,cTnT of all patients were analyzed.ResultsThe levels of HOMA-IR,HbA1c and hs-cT-nT in the diabetic cardiomyopathy group was higher than that in the simple diabetes mellitus group,with significant difference (P＜0.05).The results of the Pearson correlation analysis showed that,HOMA-IR and HbA1c were positively related to hs-cTnT(P＜0.05).When HOMA-IR took 2.85 as the critical value,HbA1c took 7.35%as the critical value,and hs-cTnT took 0.28 as the critical value,the positive predictive value,negative predictive value and accuracy of the three combined detection methods for predicting diabetic cardiomyopathy were 93.20%,95.88%,94.50%,respectively,and the actual results were basically the same,the difference was not statistically significant(P＞0.05).ConclusionThe levels of HOMA-IR and HbA1c in diabetic patients are related to myocardial injury,The combined detection of HOMA-IR, HbA1c and hs-cTnT levels may be an important reference marker for predicting the occurrence of diabetic cardiomyopathy,it is worthy of further clinical promotion.
2017 Vol. 24 (17): 48-50 [Abstract] ( 135 ) HTML (36 KB)  PDF  (0 KB)  ( 32 )
51 Diagnostic value of color Doppler ultrasonography in diabetic lower extremity arterial disease
WU Mu;LU Shun-bin
ObjectiveTo explore the diagnostic value of color Doppler ultrasonography in diabetic lower extremity arterial disease.Methods80 patients with diabetic lower extremity arterial disease treated in our hospital from December 2015 to March 2017 were selected as the subjects,CT diagnosis and color Doppler ultrasonography were used,the detection rates of the two diagnostic methods was compared.ResultsThe detection rate of TMT in patients with lower extremity arterial disease by color Doppler ultrasonography was 87.50%,the detection rate of atherosclerotic plaque was 84.29%,and the detection rate of vascular stenosis and occlusion was 86.27%,which was higher than 67.50%, 60.00%and 45.10%of CT diagnosis.The accuracy of color Doppler ultrasonography in diagnosis of plaque location was superior to CT diagnosis,with significant difference (P＜0.05).ConclusionColor Doppler ultrasonography is effective in the diagnosis of diabetic lower extremity arterial disease.It is worthy to be popularized and implemented.
2017 Vol. 24 (17): 51-53 [Abstract] ( 155 ) HTML (35 KB)  PDF  (0 KB)  ( 64 )
54 Study on thecorrelation between bodymassindex,endocrineand metabolic abnormalities in patients with polycystic ovary syndrome
HE Xiao-jie;GU Dong-hai;LI Ri-shao;HE Guo-feng1
ObjectiveTo investigate the correlation between body mass index,endocrine and metabolic abnormalities in patients with polycystic ovary syndrome(PCOS).MethodsFrom July 2014 to July 2016,90 patients with PCOS were selected and divided into the＜23 kg/m2group(43 cases),the 23-25 kg/m2group(21 cases),the＞25 kg/m2group(26 cases) according to body mass index(BMI).The indexes of insulin(INS),endocrine and metabolism in each group were tested.ResultsThe total testosterone (T)and INS levels in the＜23 kg/m2group were lower than those in the other two groups (P＜0.05),and the level of T and INS in＞25 kg/m2group was relatively highest.Compared with the＜23 kg/m2group,the level of T in the other two groups increased by 1.65(95%CI:1.33-2.06)and 4.26(95%CI:2.16-8.37)times;and the insulin resistance index(HOMA-IR)increased by 1.69(95%CI:1.42-2.00)and 4.46(95%CI:2.57-7.75)times.ConclusionObese PCOS patients are accompanied by severe endocrine disorder and metabolic disorde,and need symptomatic treatment and weight control.
2017 Vol. 24 (17): 54-56 [Abstract] ( 191 ) HTML (40 KB)  PDF  (0 KB)  ( 61 )
57 Curative effect observation of neoadjuvant chemotherapy with TP regimen treating local advanced esophageal cancer
WANG Xiao-fen;WU Shan-shan;CAI Ai-fang;XU Hong-wei;WU Ai-ling LIN You-en

ObjectiveTo explore the efficacy of TP regimen adjuvant neoadjuvant chemotherapy in the treatment of locally advanced esophageal carcinoma,and to provide a reliable basis for the treatment of locally advanced esophageal cancer.Methods34 patients with locally advanced esophageal squamous cell carcinoma who were hospitalized in our hospital from January 2014 to March 2016 were enrolled.All patients underwent neoadjuvant chemotherapy with TP regimen. The efficacy and adverse reaction were evaluated every 2 cycles.2-4 cycles after surgery,surgery can not be given for radical radiotherapy patients,and efficacy and safety of patients after treatment in patients were observed.ResultsAmong 34 patients,3 cases were complete remission after neoadjuvant chemotherapy,accounting for 8.82%,15 cases of partial remission,accounting for 44.12%;stable 15 cases,accounting for 44.12%,1 case of disease,accounting for 2.94%.The total efficiency rate was 52.94%.23 cases(67.65%)were treated with radical resection,accounting for 12 cases(35.29%),8 cases (grade 2,23.53%),3 cases(grade 3,8.82%),1 case(grade 4,2.94%)and it had no grade 5 of adverse reaction.ConclusionThe neoadjuvant chemotherapy of TP regimen can effectively reduce the tumor volume,improve the resection rate and mild adverse reaction in the treatment of locally advanced esophageal squamous cell carcinoma.It is worthy of clinical promotion and application.
2017 Vol. 24 (17): 57-59 [Abstract] ( 157 ) HTML (37 KB)  PDF  (0 KB)  ( 61 )
60 Effect of transurethral holmium laser resection of bladder tumor treating superficial bladder tumor
YAN Bin-yuan;LIU Hao;WEN Zhi-qiang;WU Tao
ObjectiveTo investigate the clinical efficacy and safety of transurethral holmium laser resection of bladder tumor and transurethral resection of bladder tumor treating superficial bladder tumor.Methods196 patients with superficial bladder tumor who underwent surgical treatment in Shenzhen Hospital of Southern Medical University from February 2014 to February 2016 were selected and they were divided into the two groups according to the operation mode,96 cases were treated with transurethral resection of bladder tumor(TURBT group),and 100 cases were treated with transurethral holmium laser resection of bladder tumor(HOLRBT group).The operative time,hospitalization time,the blood loss during operation,bladder irrigation time,catheter indwelling time,complication and tumor recurrence were compared between the two groups.ResultsTwo groups of patients with operation time and hospitalization time were no significant difference(P＞0.05),the HOLRBT group of patients in the amount of blood loss during operation was significantly less than the TURBT group(P＜0.05),bladder irrigation time and catheter indwelling time were significantly shorter than the TURBT group (P＜0.05).The amount of blood loss during operation[(26.3±4.2)ml]in patients of the HOLRBT group was significantly less than the TURBT group[(32.2±5.2)ml](P＜0.05),bladder irrigation time[(25.2±7.4)min)]and catheter indwelling time[(21.5± 5.8)h)]were significantly shorter than those of the TURBT group[(32.2±6.4)min,(34.3±8.2)h](P＜0.05).The incidence of complication in the HOLRBT group(1.0%)was significantly less than that in the TURBT group(18.8%)(P＜0.05).The recurrence rate of the HOLRBT group(12.0%)was significantly lower than that in the TURBT group(22.9%)(P＜0.05).ConclusionThe effect of HOLRBT treating superficial bladder tumor is significant with less damage,less complications,lower recurrence rate,and it is worthy of wide promotion and application in clinic.
2017 Vol. 24 (17): 60-62 [Abstract] ( 172 ) HTML (39 KB)  PDF  (0 KB)  ( 43 )
63 Influence of Thymopeptide Enteric Injection adjuvant chemotherapy on CD3+,CD4+,NK cell level in patients with ovarian cancer
WEI Shu-qing;SHI Yu-xia
ObjectiveTo study the influence of Thymopeptide Enteric Injection adjuvant chemotherapy on CD3+,CD4+, NK cell level in patients with ovarian cancer.MethodsFrom July 2013 to August 2016,98 patients with ovarian carcinoma treated in our hospital were studied,and they were divided into observation group and control group by using digital method,and there were 49 cases in each group.The patients in the observation group were given Thymopeptide Enteric Injection adjuvant chemotherapy,while the control group was given chemotherapy.CD3+,CD4+,NK cell level and so on between two groups were compared.ResultsAfter treatment,the excellent and good rate of the observation group was 95.92%,which was significantly higher than that of the control group(79.59%),and the difference was statistically significant(P＜0.05).After treatment,the level of CD3+,CD4+,and NK in the observation group were significantly higher than those in the control group,the difference was statistically significant(P＜0.01).Compared with before treatment,he white blood cell count,neutrophil count and the number of hemoglobin decreased in the two groups,and the improvement degree of WBC count and neutrophil count in the observation group was significantly better than that in the control group,the difference was statistically significant(P＜0.01).ConclusionThymopeptide Enteric Injection adjuvant chemotherapy treating patients with ovarian cancer can improve effectively CD3+,CD4+,and NK cell level,regulate the peripheral hemogram of the patients,improve the therapeutic effect.
2017 Vol. 24 (17): 63-65 [Abstract] ( 157 ) HTML (43 KB)  PDF  (0 KB)  ( 31 )
66 Clinical characteristics and prognosis of breast cancer patients under 35 years old with different molecular typing
TIAN Yong
ObjectiveTo analyze the clinical characteristics and prognosis of breast cancer patients under 35 years of age with different molecular typing.MethodsThe clinical data of 104 women under 35 years old who underwent surgical treatment in the Department of Breast Surgery in our hospital from January 2008 to December 2013 and were diagnosed of breast cancer after the surgery were analyzed retrospectively.Immunohistochemical method was used for molecular typing,and its relationship with clinicopathological features and prognosis was analyzed.ResultsIn the study,young patients with breast cancer accounted for 7.6%of the same period of breast cancer(104/1368),among whom luminal A type was in 54 cases（51.92%）,luminal B type in 16 cases(15.38%),HER-2+type in 13 cases(12.50%),and triple negative breast cancer in 15 cases(20.19%).There were significant differences of the time from palpable mass to diagnosis and pathological typing in the patients with breast cancer of all subtypes(P＜0.05).ConclusionThe molecular typing of breast cancer patients under 35 years of age is closely related to the time from palpable mass to diagnosis and tumor pathological typing.
2017 Vol. 24 (17): 66-68转76 [Abstract] ( 178 ) HTML (36 KB)  PDF  (0 KB)  ( 60 )
69 Comparison of efficacy and safety of SOX regimen and GP regimen in the treatment of advanced triple negative breast cancer
SU Wei-min;YANG Ding-hon; LIN Chang-yu
ObjectiveTo evaluate the difference in the efficacy and adverse reactions of application of Oxaliplatin plus S-1 and Gemcitabine plus Cisplatin in treatment of advanced triple negative breast cancer.MethodsAltogether 76 cases of untreated triple negative breast cancer patients with Eastern Cooperative Oncology Group(ECOG)score≤1 were treated from January 2012 to January 2015 in our hospital were randomly divided into SOX Group(38 cases)and GP Group(38 cases).Two groups were treated with Oxaliplatin plus S-1 and Gemcitabine plus Cisplatin respectively for at least 8 cycles(21 days as a cycle)so as to compare the clinical response rate(RR),overall survival(OS),progression free survival(PFS)and adverse reactionsabove GradeⅢof two groups.ResultsThe median follow-up time of the two groups was 22.4(18.2-25.7)months and 23.3(17.8-24.9)months respectively,the total RR and disease control rate(DCR)of SOX Group were 57.89%(22/38)and 76.32%(29/38)respectively in contrast with GP Group′s 63.16%(24/38)and 73.68% (28/38);no significant difference was seen between OS of two groups[HR=0.93,95%CI(0.65,1.36),P＜0.05];the PFS of GP Group was significantly higher than that of SOX Group[HR=0.71,95%CI(0.53,0.92),P＞0.05].No statistically significant difference was found in the incidence of adverse reactions above GradeⅢbetween the two groups(P＞0.05).ConclusionAlthough Gemcitabine plus Cisplatin shows priority over Oxaliplatin plus S-1 in progression free survival time，no significant difference has been seen in the total survival time and incidence of adverse reactions above GradeⅢ between two regimens.Both of the two regimens are safe and effective in treatment of advanced triple negative breast cancer.
2017 Vol. 24 (17): 69-71 [Abstract] ( 156 ) HTML (37 KB)  PDF  (0 KB)  ( 69 )
72 Clinical application of fiber bronchoscope in the treatment of pediatric Mycoplasma Pneumoniae pneumonia
WANG Long-hui;NING Ning;KUANG Yun;DING Guo-biao;WU Xiao-ling;LI Hai-yan
ObjectiveTo explore the clinical application value of fiberbronchoscopy and bronchoalveolar lavage(BAL) in the treatment of Mycoplasma Pneumoniae pneumonia (MPP)children.MethodsTotally 123 children with segmental MPP and pulmonary atelectasis,who was hospitalized and underwent fiberbronchoscopy and BAL in the Pediatrics Department of our hospital from June 2015 to March 2017 were selected as the BAL group;52 children with segmental MPP complicated with atelectasis and whose family members of children with different purposes of fiberoptic bronchoscopy or BAL in our hospital department during the same period were selected as the control group.According to the random number,the BAL group was divided into two groups:62 cases with the odd number and treated with warm saline (37℃,0.5 ml/kg per time)as the NS group;61 cases with even numbers and and treated with warm NS (37℃,0.5 ml/kg per time)+Mucosolvan(1 mg/kg per time)as the Mucosolvan group.The fever time,hospital stay,hospital expenses,treatment total efficiency and so on of each group was compared.ResultsThere was mucosal congestion and edema of different degrees were found by fiberbronchoscopy in all children of the BAL group,mucosalfollicular hyperplasia in 20.3%cases, phlegm embolus in 15.4%cases,mucosal swelling,congestion and secondary stenosis in 26.0%cases,mucosal erosion in 4.1%cases,and congenital airway constriction in 2.4%cases.The fever time of BAL group was(5.6±1.4)d,hospitalization time was(13.3±1.7)d,medical expenses was(10 425.5± 121.8)yuan,the control group fever time was(8.3±1.7)d, hospitalization time was(15.7±1.5)d,medical expenseswas(11 034.7±148.3)yuan,and the BAL group was less than the control group(P＜0.05);the effective rate of BAL group was 98.4%,the control group was 88.5%,so the BAL group was significantly higher than that of the control group (P＜0.05).The fever time of Mucosolvan group was(5.5±1.6)d,NS group was(5.7±1.2)d,there were no significant differences between the two groups(P＞0.05).But the hospitalization time and medical cost in Mucosolvan group were(12.9±1.5)d and(10 122.5±125.7)yuan,both lower than those in NS group[(13.9±1.8)d,(10 725.3±109.5)yuan,(P＜0.05).The total effective rate was 98.4%in the two groups.ConclusionFiberbronchoscopy enables the detection of tracheal mucosal injury in children with segmental MPP,which provides better guidance for treatment.BAL can shorten the fever time and hospitalization time,reduce the medical costs and improve the therapeutic effect;and BAL with Mucosolvan Injection as solvent can further shorten the hospitalization time and reduce the medical costs.
2017 Vol. 24 (17): 72-76 [Abstract] ( 168 ) HTML (48 KB)  PDF  (0 KB)  ( 56 )
77 Application of COOK balloon in promoting cervical mature during induced labor of full-term pregnancy mothers
YU Xiu-hua;HUANG Hong-li
ObjectiveTo explore the effect of COOK balloon in promoting cervical mature during induced labor of fullterm pregnancy mothers.MethodsFrom July 2014 to July 2016,106 cases of full-term pregnancy in our hospital were randomly divided into the experimental group and the control group,53 cases in each group.The experimental group was given the COOK balloon and the control group was given the Misoprostol during the labor induction.The cervical Bishop score and the total effective rate of maturing cervix of patients in the two groups were compared;the duration of induced abortion,delivery conditions,maternal-fetal outcome,adverse reaction were compared between the two groups.ResultsThe total effective rate of maturing cervix and vaginal delivery rate of the experimental group were significantly higher than those of the control group(P＜0.05).The duration of induced abortion,hospital stays,the incidence of neonatal asphyxia and fetal distress in the two groups had no significant difference(P＞0.05).The postpartum hemorrhage,injury of soft birth canal and adverse reaction of the experimental group were lower than those of the control group,the differences were statistically significant(P＜0.05).ConclusionCOOK balloon can effectively promote cervical maturity,improve the prognosis and the rate of vaginal delivery,and without prolonged labor time,has less adverse reaction,and high safety,it is worth to promoting.
2017 Vol. 24 (17): 77-79 [Abstract] ( 143 ) HTML (44 KB)  PDF  (0 KB)  ( 67 )
80 Effectiveness of laparoscope in treatment of ectopic pregnancy and its effect on postoperative pregnancy rate
GONG Cui-ju;TONG Jin-di
ObjectiveTo investigate the effect of laparoscope in treatment of ectopic pregnancy and its influence on the postoperative pregnancy rate.MethodsAltogether 118 patients with ectopic pregnancy who were treated in our hospital from January 2011 to January 2016 were selected and divided into study group and control group by random number table method,with 59 cases in each group.The control group was treated with laparotomy;while,the study group was treated with laparoscopic surgery;through 1-year postoperative follow-up,the treatment effectiveness and pregnancy rate of two groups were compared.ResultsThe duration of surgery of study group and control group was (43.57±12.68)min and (71.32±15.91)min respectively;the intraoperative blood loss of study group and control group was(45.68±5.80)ml and (165.30±17.14)ml,with significant differences between the two groups(P＜0.05);the anal exhaust time,catheter indwelling time,ambulation time and hospitalization time of the study group were shorter than those of the control group(P＜0.05);the intrauterine pregnancy rate of the study group at 1-year postoperative was 74.58%,higher than that of the control group (45.76%),the pregnancies of the two group has statistically significant difference(P＜0.05).ConclusionCompared with traditional laparotomy,laparoscopic surgery has less traumatic and faster in postoperative recovery for ectopic pregnancy patients,and can significantly improve the pregnancy rate,which is suitable for popularization and application.
2017 Vol. 24 (17): 80-82 [Abstract] ( 139 ) HTML (37 KB)  PDF  (0 KB)  ( 57 )
83
The hazards analysis of epilepsy children morbidity
The hazards analysis of epilepsy children morbidity[J]. 中国当代医药, 2017,24(17): 83-85')" href="#"> ZHANG Su-fang;CHENG Peng
ObjectiveTo approach hazards of epilepsy children morbidity.MethodsThe 120 children with epilepsy in our hospital from January 2013 to January 2015 were selected as epilepsy group,then 100 healthy children check-up in our hospital in the same period were selected as control group.The general features,epilepsy family history,born,anamnesis and epilepsy were compared between the two groups.The multiple-factor non-conditional Logistic regression analysis was used to analyzed the epilepsy hazards.ResultsThe proportion of children whose epilepsy onset at 0-1 age in the epilepsy group was higher than the control group,proportion of children whose epilepsy onset at＞5-6 age was lower than the control group(P＜0.05);the proportion of epileptic seizure in children with epilepsy family history,mother age pregnancy,birth injury,hyperpyretic convulsion,brain infection,craniocerebral injury was higher,the differences were statistical significance(P＜0.05).The multiple-factor non-conditional Logistic regression analysis showed that,birth injury,mother age pregnancy,hyperpyretic convulsion,craniocerebral injury,epilepsy family history were hazards of epileptic seizure (P＜0.05).ConclusionAnalyzing of the risk factors of the epilepsy,the birth injury,mother age pregnancy,hyperpyretic convulsion,craniocerebral injury,epilepsy family history are hazards of epileptic seizure,which can guide clinical treatment epilepsy for providing reliable theory basis.
2017 Vol. 24 (17): 83-85 [Abstract] ( 119 ) HTML (34 KB)  PDF  (0 KB)  ( 63 )
86 Observation on the effect of infrared radiation combined with antibiotic intravenous drip in the treatment of chronic pelvic inflammatory disease
HUANG Rui-lian
ObjectiveTo analyze the effect of infrared light irradiation combined with antibiotic intravenous infusion on chronic pelvic inflammatory disease.Methods80 patients with chronic pelvic inflammatory disease treated in our hospital from October 2015 to February 2017 were randomly divided into two groups:40 cases of the control group were given intravenous infusion of antibiotics,while 40 cases of the intervention group were given infrared light irradiation with intravenous infusion of antibiotics.The treatment effect of patients with chronic pelvic inflammatory disease,time of leucorrhea test returned to normal,the time of elimination of abdominal pain,the time of disappearance of lower abdominal bulge,the time of elimination of pelvic mass were compared between the two groups;the levels of TNF-α,CRP,IL-1β and IL-6 and quality of life before and after intervention were compared between the two groups.ResultsTreatment effect was compared between the two groups,and the intervention group was higher than that in the control group (P＜0.05);time of leucorrhea test returned to normal,the time of elimination of abdominal pain,the time of disappearance of lower abdominal bulge,the time of elimination of pelvic mass were compared between the two groups,the intervention group were short than those of the control group,the differences were statistically significant(P＜0.05);the levels of TNF-α, CRP,IL-1β and IL-6 and other inflammatory factors were compared between two groups,there were no significant differences before intervention between the two groups(P＞0.05),while the levels of TNF-α,CRP,IL-1β and IL-6 and other inflammatory factors after the intervention of the two groups were superior to those before intervention,the differences were statistically significant(P＜0.05).Quality of life was compared between the two groups,there was no significant differencebetween the two groups before intervention(P＞0.05);after intervention,the intervention group was superior to the controlgroup,the difference was statistically significant(P＜0.05).ConclusionInfrared light irradiation combined with antibiotic intravenous infusion is effective in the treatment of chronic pelvic inflammatory disease,it can effectively improve the symptoms,shorten the time to eliminate symptoms,reduce the level of inflammation,improve the quality of life of patients,it is worth promoting.
2017 Vol. 24 (17): 86-88 [Abstract] ( 122 ) HTML (43 KB)  PDF  (0 KB)  ( 52 )
89 Comfort comparison on the therapeutic efficacy of heated humidified highflow nasal can-nula and nasal continuous positive airway pressure in treating neonatal respiratory distress syndrome
HUANG Ling;AO Zhen-zhen
ObjectiveTo compare the therapeutic efficacy and therapeutic comfort of heated humidified high-flow nasal can-nula(HHFNC)and nasal continuous positive airway pressure(NCPAP)in treating neonatal respiratory distress syndrome (NRDS).Methods60 patients with NRDS admitted to our hospital from January 2016 to January 2017 were selected as the study object.60 patients were randomly divided into study group and control group by random number table method,with 30 cases in each group,the patients of the two groups were given two kinds of airway treatments of HHFNC and NCPAP respectively,the treatment comfort level and related complications of patients in two groups were compared.ResultsThe EDIN score of the children in the study group was significantly lower than that in the control group, the difference was statistically significant(P＜0.05);the incidence of complications in the study group was fewer than that of the control group,the difference was statistically significant(P＜0.05).ConclusionCompared with nasal continuous positive airway pressure,providing heated humidified high-flow nasal can-nula for child patients with neonatal respiratory distress syndrome can significantly improve the comfort,and reduce the incidence of complications such as nose injury, so that it has a certain promotional value.
2017 Vol. 24 (17): 89-91 [Abstract] ( 124 ) HTML (37 KB)  PDF  (0 KB)  ( 40 )
92 The comparison of therapeutic effects with Reciproc and Mtwo root canal preparation system in one time instant root canal filling for mandibular first molar
ZHOU Lan
ObjectiveTo observe the comparison of therapeutic effects with Reciproc and Mtwo root canal preparation system in one time instant root canal filling for mandibular first molar.MethodsFrom June 2015 to June 2016,72 patients for one time instant root canal filling for mandibular first molar in our hospital were randomly divided into R group and M group,36 cases in each group.R group and M group were treated by Reciproc and Mtwo root canal preparation system, the root canal preparation time,complications(such as perforations,ledge and broken instruments),correct fill-in rate,endodontic interappointment pain and total efficacy were comparatively analyzed.ResultsThe root canal preparation time in R group and M group was(120.23±38.67)s and(72.82±36.22)s,the EIAP rate and VAS score in R group were significantly lower than those in M group(P＜0.05).There were no significant statistical differences in complications rate,correct fill-in rate and total efficacy between two groups(P＞0.05).ConclusionIn contrast with Mtwo root canal preparation system,using the Reciproc root canal preparation system in one time instant root canal filling for mandibular first molar can significantly shorten the root canal preparation time,obviously reduce the endodontic interappointment pain,both groups can achieve good clinical effect.
2017 Vol. 24 (17): 92-94 [Abstract] ( 124 ) HTML (41 KB)  PDF  (0 KB)  ( 22 )
95 Discussion on surgical approach of coblation tonsillectomy
CHEN Qia-xin;LIU Yi;ZHOU Jia-liang;MAI Fei;ZHANG Xin-li
ObjectiveTo explore the optimal surgical approach of coblation tonsillectomy.MethodsThe data and operation of children patients undergone coblation tonsillectomy from August 2014 to July 2015 were retrospectively analyzed.According to the morphology and location of tonsils,all patients were divided into embedding,adhesive,and common types.The different surgical approaches in varied types of tonsillectomy were evaluated.The evaluated indexes were score of adhesive soft tissue range on tonsillectomy and score of postoperative pain.ResultsThe score of removing soft tissue via velopharyngeal approach in the common and embedded type of tonsils was higher than that via pharynxpalate approach,with significant difference(P＜0.05).There were no significant differences in the scores of removing soft tissue between the two operation methods in the adhesive type of tonsil(P＞0.05).The score of pain via pharynx-palate approach in the common and embedded adhesive type of tonsils at the first,second,third days after the operation was lower than that via pharynx-palate approach,with significant difference(P＜0.05).There were no significant differences in the score of pain at the first,second,third days after the operation between the two operation methods in the adhesive type of tonsil (P＞0.05).ConclusionCoblation tonsillectomy via pharynx-palate approach has some advantages including small trauma and few postoperative pain reactions,especially for embedding-type tonsil,which is worthy of promotion.
2017 Vol. 24 (17): 95-98 [Abstract] ( 121 ) HTML (45 KB)  PDF  (0 KB)  ( 43 )
99 Curative effect difference between prepared warm gutta-percha and cold gutta-percha in one-time instant root canal filling for chronic apical periodontitis
HONG Zhuo-zhuo
ObjectiveTo compare the curative effect difference between prepared warm gutta-percha and cold guttapercha in one-time instant root canal filling for chronic apical periodontitis.MethodsFrom February 2015 to February 2016,64 chronic apical periodontitis patients in our department were randomly divided into control group by the outpatient number(32 patients with 33 involved teeth)and experimental group(32 patients with 34 involved teeth).The experimental group and control group were treated by prepared warm gutta-percha and cold gutta-percha in one-time instant root canal filling.All patients were followed up for 1 week and 12 months.The root canal filling quality,pain level after 1 week and curative effect after 12 months were comparatively analyzed.ResultsThe correctly fill-in rate in experimental group and control group had no significant difference (Z=1.77，P＞0.05).The pain rate and VAS score in experimental group were 6.25%and (1.02±0.36)scores,which were significantly lower than control group of 28.13%and (2.23±0.85)scores(P＜0.05).The cure rate and total effective rate after 12 months in experimental group was 96.88%，which were significantly better than control group of(75.00%)(P＜0.05).ConclusionPrepared warm gutta-percha in onetime instant root canal filling for chronic apical periodontitis have a better root canal filling quality and also can obviously lower the pain level and significantly enhance the curing rate.
2017 Vol. 24 (17): 99-101 [Abstract] ( 146 ) HTML (37 KB)  PDF  (0 KB)  ( 36 )
102 Effect of corneal plastic surgery on ocular regulation parameters and stereopsis in myopia patients
WU Lai-wei
ObjectiveTo investigate the effect of corneal plastic surgery on ocular regulation parameters and stereopsis in myopia patients.Methods60 patients with myopia in our hospital from December 2014 to December 2016 as the observation of this study,with the equivalent spherical degree of 60 cases of myopia patients were divided into three groups, among them,low myopia(diopter＜-2.00 D)in 27 cases，moderate myopia(diopter between-2.00--4.00 D)18 cases，high myopia(diopter＞-4.00 D)15 cases.60 cases of myopic patients were treated with corneal plastic surgery,compared with three groups of patients with myopia eye regulation parameters and stereopsis indicators.ResultsThe uncorrected visual acuity and refraction were significantly improved in 60 patients with myopia after treatment(P＜0.05).There were significant differences in the adjustment range and adjustment sensitivity between the three groups of patients with myopia (P＜0.05) Between the difference in distance vision，near vision difference,stereoscopic vision difference between the significant differences(P＜0.05).ConclusionThe treatment of myopia with corneal plastic surgery can improve the visual acuity and eye regulation parameters of the patients,and improve the stereoscopic sharpness.
2017 Vol. 24 (17): 102-104 [Abstract] ( 124 ) HTML (37 KB)  PDF  (0 KB)  ( 38 )
105 Evaluation of the effect of IPS e.max CAD high inlay in repairing unmyelinated posterior teeth
YANG Yang
ObjectiveTo observe the clinical effect of IPS e.max CAD porcelain inlay in repairing unmyelinated posterior teeth.Methods68 patients with thoracic incisors in our hospital from May 2013 to February 2016 were divided into two groups,the control group(n=35)and the control group(n=33)33 cases of 33 patients;the use of porcelain Rui engraved four generations(CAD/CAM)system made all-ceramic high inlay,the observation group used IPSe.max CAD materials,the control group used Cerec Blocs materials.One year after follow-up,the American Public Health Association (USPHS）improved criteria were used to evaluate the success rate of the two groups.ResultsAfter 1 year,the observation group was superior to the control group in the aspects of margin adhesion and restoration integrity,the difference was statistically significant(P＜0.05).In the reconstructed body shape,color matching and secondary caries,the difference was not statistically significant(P＞0.05).ConclusionThe prosthesis produced by IPSe.max CAD material has a high success rate in the treatment of unmyed posterior teeth after root canal therapy.The recent effect is better than Cerec Blocs,but the longterm effect needs to be further evaluated.
2017 Vol. 24 (17): 105-107 [Abstract] ( 129 ) HTML (35 KB)  PDF  (0 KB)  ( 27 )
108 Influence of Sufentanil combining with Ropivacaine in different concentrations on analgesia and uterine contraction in pregnant women
OU Shao-mei;HUANG Min;HAN Bao-jiang;PENG Xue-mei
ObjectiveTo explore the influence of Sufentanil combining with Ropivacaine in different concentrations on analgesia and uterine contraction in pregnant women.Methods128 pregnant women who would given birth in our hospital from August 2015 to March 2016 undergone epidural analgesia were selected and randomly divided into the control group,the low dose group,the medium dose group,the high dose group,32 cases in each group.The control group was given 0.1%Ropivacaine alone,the low dose group was given 0.2 μg/ml Sufentanil combining with 0.1%Ropivacaine,the medium dose group was given 0.4 μg/ml Sufentanil with 0.1%Ropivacaine,the high dose group was given 0.6 μg/ml Sufentanil with 0.1%Ropivacaine.The VAS score,the time of labor,the Apgar score of newborns and the incidence rate of adverse reactions were comprehensively compared among the four groups before and after administration.ResultsThere was no significant difference in the VAS score among the four groups before administration(P＞0.05).10 minutes after administration,total opening of uterine neck,anddelivery of baby,with the increase of Sufentanil dose,the VAS scores were greatly decreased,which were all lower than that in the control group(P＜0.05).The first stage of labor in the low,middle and high dose group was shorter than that in the control group,among them,the first stage of labor in the low and middle dose group were both shorter in comparison with that in the high dose group (P＜0.05).There was no significant difference in the second stage of labor,the third stage of labor,and Apgar scores of newborns among four groups(P＞0.05).The incidence rate of adverse reaction in the high dose group was lower and higher in the middle dose group(P＜0.05).ConclusionFor pregnant women undergone epidural analgesia,0.4 μg/ml Sufentanil with 0.1%Ropivacaine obtains great analgesic effect in high safety.It can greatly shorten the first stage of labor and is worthy of clinical promotion.
2017 Vol. 24 (17): 108-110 [Abstract] ( 138 ) HTML (39 KB)  PDF  (0 KB)  ( 39 )
111 Research on application of target-controlled infusion of Remifentanil compounded with Propofol in gynecologic laparoscopic surgery
LI Guo-qiang;LIU Jin-long;LI Bin
ObjectiveTo investigate the application of target-controlled infusion (TCI)of Remifentanil compounded with Propofol in gynecologic laparoscopic surgery.MethodsAltogether 100 patients who were scheduled to undergo gynecological laparoscopic surgery from December 2014 to April 2016 in our hospital were selected and randomly divided into the observation group and the control group,with 50 cases in each group.The observation group was treated with TCI anesthesia of Remifentanil compounded with Propofol,while,the control group was treated with TCI anesthesia of Fentanyl compounded with Propofol.The postoperative recovery index,blood pressure and heart rate changes and the incidence rate of adverse reactions were compared between the two groups.ResultsThe respiratory recovery time,eye opening time and extubation time of the observation group were significantly shorter than those of the control group,with significant difference(P＜0.05).The level of systolic blood pressure(SBP),diastolic blood pressure(DBP)and heart rate (HR)at post-extubation 1 min and post-pneumoperitoneum 3 min of the observation group were significantly lower than those of the control group,with significant difference (P＜0.05).The incidence rate of adverse reaction rate of the observation group was lower than that of the control group,with significant difference (P＜0.05).ConclusionTCI of Remifentanil compounded with Propofol can effectively maintain hemodynamic stability and promote patients′early recovery with less adverse reactions and ideal anesthesia effect,which can be widely used in gynecological laparoscopic operation and is of great significance in clinical application.
2017 Vol. 24 (17): 111-113 [Abstract] ( 128 ) HTML (40 KB)  PDF  (0 KB)  ( 42 )
114 Comparative analysis of spinal-epidural combined anesthesia and epidural anesthesia in the elderly patients undergoing transurethral resection of prostate
SHI Hui-zhen
ObjectiveTo investigate the comparison of spinal-epidural combined anesthesia and epidural anesthesia in the elderly patients undergoing transurethral resection of prostate.Methods90 patients undergoing transurethral resection of prostate from May 2014 to June 2016 in our hospital were selected and divided into the combined anesthesia group (50 cases)and the epidural anesthesia group(40 cases)according to different anesthesia methods.The combined anesthesia group was given spinal-epidural combined anesthesia,and the epidural anesthesia group was given epidural anesthesia. The systolic and diastolic blood pressures at different time points in the two groups were observed.The anesthesia onset time,completion time of blockage,the highest sensory block plane after surgery in the two groups were recorded,and anesthesia effect were compared in the two groups.ResultsThere was no significant difference in the systolic and diastolic blood pressure after anesthesia,at 5 min,10 min,15 min and 20 min between the two groups(P＞0.05).The onset time of anesthesia and completion time of blockage in the combined anesthesia group were both lower than thoseintheepidural anesthesia group,the excellent and good rate of anesthesia in the combined anesthesia group was higher than that in the epidural anesthesia group,with significant difference(P＜0.05).ConclusionThe application of spinal-epidural combined anesthesia in the elderly patients undergoing transurethral resection of prostate can shorten the onset time of anesthesia, with a significant effect of anesthesia,which is worthy of clinical promotion and application.
2017 Vol. 24 (17): 114-116 [Abstract] ( 124 ) HTML (40 KB)  PDF  (0 KB)  ( 33 )
117 Application of Nalbuphine combined with Ropivacaine for postoperative analgesia of hemorrhoid
LI Hong-tao;XIAO Li-bo;WANG Jian-ming
ObjectiveTo explore the safety and effect of Nalbuphine combined with Ropivacaine for postoperative analgesia of hemorrhoid.Methods120 patients with severe hemorrhoids undergoing anorectal surgery from September 2016 to March 2017 in our hospital were selected,the ASA classification was fromⅠtoⅡgrade.All patients were divided into group A,B and C according to the random number table method,40 cases in each group.All patients were given postoperative epidural self-controlled analgesia.Group A was given 0.5 μg/ml Sufentanil combined with 0.15%Ropivacaine, group B was given 0.1 mg/ml Nalbuphine combined with 0.15%Ropivacaine,group C was given 0.2 mg/ml Nalbuphine combined with 0.15%Ropivacaine.The VAS scores at postoperative 8,12,24,48 h and at the first defecation in the each group were recorded,while the incidence of adverse reactions such as anal edema,pruritus,nausea,vomiting,and difficulty in breathing in each group were observed.Results The VAS scores of group A and group C at 12,24 and 48 h were lower than those in group B,with significant difference(P＜0.05).The VAS score at the first defecation of group C was lower than that of group A and group B,with significant difference (P＜0.01).The incidence rate of pruritus,nausea and vomiting in group B and group C was lower than that in group A,with significant difference(P＜0.05).Conclusion0.1 mg/ml or 0.2 mg/ml Nalbuphine combined with 0.15%Ropivacaine is safe and effective for postoperative analgesia of hemorrhoid,and the incidence rate of itching and nausea and vomiting is lower than that of 0.5 ug/ml Sufentanil combined with 0.15%Ropivacaine.
2017 Vol. 24 (17): 117-119转129 [Abstract] ( 119 ) HTML (45 KB)  PDF  (0 KB)  ( 33 )
120 Comparison of the influence of depth,moderate and superficial anesthesia on postoperative cognitive function in elderly patients undergoing general anesthesia
WANG Jing;SHI Lei;TIAN Xian-shu
ObjectiveTo explore the influence of depth,moderate and superficial anesthesia on postoperative cognitive function in elderly patients undergoing general anesthesia.Methods69 elderly patients scheduled to undergo elective gastrointestinal tumor surgery under general anesthesia in our hospital from February 2014 to February 2017 were selected and randomly divided into group L,group M and group D,23 cases in each group.Group L was given superficial anesthesia,group M was given moderate anesthesia,and group D was given deep anesthesia.The time of anesthesia,the amount of fluid infusion,the amount of bleeding,the recovery time of the directional force,the heart rate (HR),the mean arterial pressure (MAP),the incidence rate of POCD and the MMSE score before and after the operation were compared between the three groups.ResultsThere was no significant difference in the time of anesthesia,the amount of fluid infusion and the amount of bleeding between the three groups (P＞0.05).The recovery time of directional force in group D was significantly longer than that in group L and group M,with significant difference(P＜0.05).The level of HR,MAP before intubation,1 hour and 2 hours during the operation in group D were significantly lower than those in group L and group M,with significant difference (P＜0.05).There was no significant difference in the level of HR and MAP after the restoration of the directional force at 30 min between the three groups(P＞0.05).The level of HR and MAP before intubation, 1 hour and 2 hours during the operation in the three groups were significantly lower than those before induction,with significant difference(P＜0.05).The incidence rate of POCD at 24 hours and 48 hours after operation in group D was significantly lower than that in group L and group M,with significant difference(P＜0.05).The incidence rate of POCD at 24 hours and 48 hours after operation in group M was significantly lower than that in group L,with significant difference (P＜0.05).The MMSE scores at 1 week after operation in the three groups was significantly lower than that before the operation,with significant difference(P＜0.05).The MMSE score at 3 months after operation in group L and group M was lowerthan that before operation,with significant difference(P＜0.05).There was no significant difference in MMSE score in group D between before operation and at 3 months after operation(P＞0.05).ConclusionFor elderly patients with general anesthesia,deep anesthesia can effectively reduce the incidence rate of POCD in elderly patients,compared with other depth of anesthesia,the patient′s cognitive function will be less affected.
2017 Vol. 24 (17): 120-123 [Abstract] ( 158 ) HTML (55 KB)  PDF  (0 KB)  ( 38 )
124 Clinical effect of Tongxinluo combined with Atorvastatin in the treatment of unstable angina pectoris of coronary heart disease
WU Jia-long
bjectiveTo investigate the clinical effect of Tongxinluo combined with Atorvastatin in the treatment of unstable angina pectoris of coronary heart disease.Methods140 cases with unstable angina pectoris of coronary heart disease treated in our hospital from March 2015 to August 2016 were selected and divided into the experiment group and reference group according to their parity of admission order,and there were 70 cases in each group.Control group was treated with Atorvastatin,while the experiment group was treated with Tongxinluo plusing Atorvastatin.Blood lipid level, incidence rate of adverse reaction and clinical effect between the two groups were compared.ResultsCompared with before treatment,LDL-C,TG,TC level were significantly decreased in two groups (P＜0.05).LDL-C,TG,TC level in the experiment group was significantly lower than that of reference group after treatment,and HDL-C level was higher than that of reference group,and the difference was statistically significant(P＜0.05).The total effective rate in the experimental group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).There was no statistical diffference of incidence rate of adverse reaction between the two groups(P＞0.05).ConclusionTongxinluo combined with atorvastatin in the treatment of unstable angina pectoris of coronary heart disease can restore normal blood lipid level,make the blood vessel plaques more stable,and can significantly improve myocardial blood supply,and it dose not increase adverse reactions.
2017 Vol. 24 (17): 124-126 [Abstract] ( 128 ) HTML (42 KB)  PDF  (0 KB)  ( 34 )
127 Effect observation of Thalidomide Tablets combined with Tripterygium Glycosides tablets treating oral lichen planus
CHEN Mei-hua;HUANG Xiao-qing
ObjectiveTo investigate the effect of Thalidomide Tablets combined with Tripterygium Glycosides tablets treating oral lichen planus.Methods108 patients with oral lichen planus admitted into periodontics&oral department from September 2014 to October 2016 were selected as study object and they were divided into the routine group(injected with Triamcinolone Acetonide locally)and observation group(treated with the drugs of Thalidomide combined with Tripterygium)according to the end of single or double numbers of visiting numbers and there were 54 cases in each group.The treatment effect,pain and erosion score and incidence of adverse reactions were compared between the two groups.ResultsThe effective rate of the observation group was 96.3%,which was higher than that of the control group (87.0%)(P＜0.05).There was no significant difference in pain and erosion score between the groups on admission(P＞0.05), and the score of pain and erosion in the observation group were lower than those in the control group (P＜0.05).The incidence of adverse reactions in the observation group was 7.4%,which was lower than that of the control group (16.7%) (P＜0.05).ConclusionThe effect of Thalidomide Tablets combined with Tripterygium Glycosides tablets is better in the treatment of oral lichen planus.
2017 Vol. 24 (17): 127-129 [Abstract] ( 155 ) HTML (36 KB)  PDF  (0 KB)  ( 41 )
130 Effect of Recombinant Human Brain Natriuretic Peptide treating acute decompensated heart failure
GUO Min
ObjectiveTo explore the effect of Recombinant Human Brain Natriuretic Peptide treating acute decompensated heart failure.Methods100 patients with acute decompensated heart failure treated in our hospital from May 2015 to May 2016 were selected and they were divided into the two groups using the lottery method,and there were 50 patients in each group.The control group and observation group was treated by Isosorbide Mononitrate and Recombinant Human Brain Natriuretic Peptide.6-minute walking distance,24-hour urine output,respiratory rate,heart rate and the cardiac function indexes were compared between the two groups.Results6-minute walking distance[(114.69±6.89)m],24-hour urine output[(2458.32±68.58)ml],respiratory rate[(18.65±1.54)times/min],heart rate[(74.56±2.65)times/min],LVEDD [(60.96±2.02)mm],LVESD[(46.36±1.38)mm],LVEF[(46.36±1.38)%]were better than those of control group [(85.43± 5.32)m,(1453.28±11.58)ml,(24.31±1.05)times/min,(84.62±3.44)times/min,(65.54±1.83)mm,(55.68±1.62)mm,(43.46± 1.84)%](P＜0.05).ConclusionThe effect of Recombinant Human Brain Natriuretic Peptide treating acute decompensated heart failure is significant.
2017 Vol. 24 (17): 130-132 [Abstract] ( 136 ) HTML (40 KB)  PDF  (0 KB)  ( 31 )
133 Effect observation of Glucocorticoid combined with Ulinastatin in the treatment of severe pneumonia in children
YU Hua
ObjectiveTo analyze the clinical effect of Glucocorticoid combined with Ulinastatin in the treatment of children with severe pneumonia.Methods120 children with severe pneumonia aged 2～59 months treated in our hospital from December 2014 December 2016 were randomly selected and they were randomly divided them into two groups, and there were 60 cases in each group.The control group was given conventional treatment,and the observation group was treated with Glucocorticoid combined with Ulinastatin on the basis of this.The total effective rate,the remission time of relative symptoms and signs were compared between the two groups.ResultsAfter treatment,the total effective rate of observation group was 98.3%,which was significantly higher than that in the control group (80.0%),and the difference was statistically significant(P＜0.05).The remission time of fever,dyspnea,hypoxemia in the observation group were shorter than those of the control group(P＜0.05).ConclusionGlucocorticoid combined with Ulinastatin in the treatment of severe pneumonia in children is effective,and it can alleviate symptoms quickly.It is worthy of clinical promotion and application.
2017 Vol. 24 (17): 133-135 [Abstract] ( 127 ) HTML (34 KB)  PDF  (0 KB)  ( 38 )
136 Clinical effect of acupuncture and regulation tendon plus Duhuojisheng Decoction in the treatment of postpartum lumbago
FENG Zhi-wen
ObjectiveTo explore clinical effect of acupuncture and regulation tendon plus Duhuojisheng Decoction in the treatment of postpartum lumbago.MethodsFrom January 2015 to January 2017,60 patients with postpartum lumbago treated in Department of traditional Chinese medicine of our hospital were selected and randomly divided into the control group and the study group,30 cases in each group.The control group was only treated with Duhuojisheng Decoction,the study was treated with acupuncture and regulation tendon plus Duhuojisheng Decoction.The VAS score,the total effective rate and recurrence rate were compared between the two groups.ResultsThe VAS score after treatment in the study group was lower than that in the control group,with significant difference(P＜0.05).The total effective rate of the study group was 83.3%,which was higher than 63.3%of the control group,with significant difference(P＜0.05).The recurrence rate of the study group was lower than that of the control group,with significant difference(P＜0.05).ConclusionThe effect of acupuncture and regulation tendon plus Duhuojisheng Decoction in the treatment of postpartum lumbago is significant,the recurrence rate is low,which is worthy of clinical promotion and application.
2017 Vol. 24 (17): 136-138 [Abstract] ( 139 ) HTML (41 KB)  PDF  (0 KB)  ( 38 )
139 Clinical observation of raditional Chinese medicine physiotherapy in improving the tendon adhesion of hand flexor tendon injury after repair of zoneⅡ
HU Ming-long;YI Xiu-zhen;ZHONG Song-jie;YIN Shi-hai;YIN Jin-hua
ObjectiveTo explore the clinical effect of traditional Chinese medicine physiotherapy in improving the tendon adhesion of hand flexor tendon injury after repair of zoneⅡ.MethodsFrom January 2016 to January 2017,60 patients with flexor tendon injury of zoneⅡ in our hospital were selected and randomly divided into the control group and the observation group,30 cases in each group.The control group was fixed with plaster after operation,and the plaster was removed after 4 weeks,no other rehabilitation methods were used.The observation group was treated with ultra-laser and traditional Chinese medicine directional drug therapy.The clinical efficacy of the two groups was compared.ResultsThe VAS scores at the time of discharge in the two groups was lower than that at the time of admission,with significant dif ference(P＜0.05).The VAS scores at the time of discharge in the observation group was lower than that in the control group, with significant difference(P＜0.05).The TAM scores of hand function at 4,6 and 8 weeks after operation in the observation group was significantly higher than that in the control group at the same time,with significant difference (P＜0.05).The excellent and good rate of TAM of hand function at 8 weeks after operation in the observation group was 93.3%,which was significantly higher than that of the control group(56.7%),with significant difference(P＜0.05).ConclusionThe effect of traditional Chinese medicine on the rehabilitation of flexor tendon is very helpful,and the rehabilitation rate is high.
2017 Vol. 24 (17): 139-141 [Abstract] ( 151 ) HTML (37 KB)  PDF  (0 KB)  ( 39 )
142 Effect of combination of traditional Chinese and Western medicine in the treatment of herpes zoster
ZHOU Jun
ObjectiveTo explore the clinical effect of combination traditional Chinese and Western medicine in the treatment of herpes zoster.MethodsA retrospective analysis of 82 cases of herpes zoster whoreceived：treatment from January 2013 to December 2016 in department of dermatology of our hospital,according to the different treatment methods,all patients were divided into the control group (42 cases)and the observation group (40 cases).The control group was given antiretroviral therapy,neurotrophic therapy,analgesic therapy or glucocorticoid therapy according to individual condition.The observation group was given traditional Chinese medicine syndrome differentiation,proprietary Chinese medicine treatment or external drug treatment on the basis of Western medicine treatment.The clinical effects of the two groups was compared.ResultsThe total effective rate of the observation group was 97.50%,which was higher than 80.95% of the control group,with significant difference(P<0.05).The analgesic time,the stopping time of blister,the time of complete scab and the time of complete extinction of the lesions in the observation group was shorter than that in the control group, with significant difference(P＜0.05).There was no significant difference in the incidence rate of post traumatic neuralgia, hospitalization time and hospitalization expenses between the two groups(P＞0.05).ConclusionThe effect of combination traditional Chinese and Western medicine in the treatment of herpes zoster is better than that of Western medicine,and it is worthy of clinical promotion and application.
2017 Vol. 24 (17): 142-144 [Abstract] ( 135 ) HTML (42 KB)  PDF  (0 KB)  ( 30 )
145 Clinicalstudyon combination oftraditionalChineseand Western medicine in the treatment of respiratory failure due to chronic obstructive pulmonary disease
SHEN Wang-feng
ObjectiveTo explore the treatment effect of combination of traditional Chinese and Western medicine in the treatment of respiratory failure due to chronic obstructive pulmonary disease (COPD).Methods80 cases of respiratory failure treated with COPD in our hospital from November 2015 to November 2016 were selected and randomly divided into the observation group and the control group,40 cases in each group.The observation group was treated with combination of traditional Chinese and Western medicine,the control group was treated with conventional Western medicine. The clinical treatment effects of the two groups was compared.ResultsThe total effective rate of the observation group was 90.0%,which was significantly higher than that of the control group(62.5%),with significant difference(P＜0.05).The level of PaO2in the two groups after treatment was significantly higher than that before treatment,and the level of PaCO2in the two groups after treatment was lower than that before treatment,with significant difference(P＜0.05).The level of PaO2in the observation group after treatment was significantly higher than that in the control group after treatment,the level of PaCO2in the observation group after treatment was significantly lower than that of the control group,with significant difference(P＜0.05).There were no complications in the two groups.ConclusionThe curative effect of combination of traditional Chinese and Western medicine is significantly better than that of conventional Western medicine.There is no complications,it is worthy of clinical popularization and application.
2017 Vol. 24 (17): 145-147 [Abstract] ( 130 ) HTML (39 KB)  PDF  (0 KB)  ( 36 )
148 Investigation analyzing of vaccination grid management for floating children
ZENG Yu-hua ZENG Cui-lian LI Xiu-juan
ObjectiveTo explore the investigation of vaccination grid management for floating children.MethodsThe vaccination of 5000 children aged 0-6 years in Longdong Community from September 2016 to April 2017 were investigated by means of census methods,300 cases were extracted for parent questionnaire investigation,the influence factor of vaccination grid management were explored by multivariate Logistic regression analysis.ResultsThe inoculation rate of BCG,Hep B×3,OPV×3,OPV④,DPT×3,DPT④,MV①,MV②,Meningococcus A×2,Meningococcus A+C①,Hep A were 99.56%,95.56%,94.35%,61.47%,95.69%,86.19%,89.42%,88.89%,96.93%,87.37%,92.71%,72.64%,87.82%,respectively. Whether or not to enter the kindergarten or enter the school should be confirmed by the vaccination certificate was the main factor affecting the whole coverage rate of"five seedlings" (P＜0.05).Conclusion Analyzing vaccination grid management for floating children can provide reliable theoretical basis for guiding vaccination.
2017 Vol. 24 (17): 148-150转156 [Abstract] ( 145 ) HTML (39 KB)  PDF  (0 KB)  ( 33 )
151 Nutritional status of patients with malignant tumor and its effect on quality of life
JI Chao-na HUANG Wen-juan
ObjectiveTo investigate the nutritional status of patients with malignant tumor and its effect on quality of life.MethodsA total of 300 malignant tumor patients treated in our hospital from March 2016 to March 2017 were selected as study subjects,and investigate by General Information Questionnaire,subjective global assessment(SGA),EORTC Core Quality of Life Questionnaire-C30(EORTC QLQ-C30).The effect of nutritional status on the quality of life was analyzed by variance analysis.ResultsThe incidence of malnutrition among the 300 inpatients was 59.4%(178/300);the higher the degree of malnutrition in the patient,the lower the overall health status,the role function,the social function,the physical function,and the emotional field score,and the higher the fatigue,insomnia,shortness of breath,loss of appetite,pain, constipation,nausea and vomiting,and diarrhea field score.ConclusionMost patients with malignant tumor have malnutrition,which will affect their quality of life.We should take appropriate intervention to improve the nutritional status of patients,thereby improving the quality of life of patients with malignant tumors.
2017 Vol. 24 (17): 151-153 [Abstract] ( 158 ) HTML (38 KB)  PDF  (0 KB)  ( 34 )
157 Research and discussion on the training mode of professional core competence in operation room
DENG Rui
ObjectiveTo explore the training mode of core competence in operation room.MethodsFrom January to December 2015,personalized,diversified,effective training and assessment and so on was conducted for nurses of our hospital around the"professional nurses core competence construction guide"and other documents.The assessment results of professional competency of nurses in 1 year(from January to December 2014),and the satisfaction degree of doctors and patients for nurses in operation room were compared.ResultsAfter the training,the professional nurses in the operation room had a significant improvement in the cooperation ability and the comprehensive quality of the nurses.The satisfaction degree score of doctors in operation room to nurses and the satisfaction degree score of patients to nurses before and after training was a statistical difference (P＜0.05).ConclusionThe development of group level training can significantly improve the comprehensive quality and ability of clinical nurses,which is worthy of clinical application and promotion.
2017 Vol. 24 (17): 157-159 [Abstract] ( 128 ) HTML (42 KB)  PDF  (0 KB)  ( 37 )
160 Exploration of specialized management mode of inspection report on sexually transmitted diseases report as well as effect of the diagnosis and treatment
SHI Zhao-ju
ObjectiveTo explore the effectiveness of specialized management mode of inspection report on sexually transmitted diseases(STD).MethodsFrom January 2012 to December 2014,779 outpatients with STD were labeled as the new model group.From January 2010 to December 2011,720 STD patients were identified as the old model group. The change of management indicators like epidemic report and syphilis screening and treatment in the two groups were compared and analyzed.ResultsIn the new model group,the timely and integrated rate of reporting syphilis,gonorrhea and genital chlamydia trachomatis infection,the diagnostic accuracy rate of syphilis typing and its accomplishing rate, and syphilis screening rate from patients suffering from gonorrhea/chlamydia trachomatis infection in genital tract and completion rate of treatment were all much higher than those in the old model group with statistical differences (P＜0.05).ConclusionSpecialized management mode of inspection report on STD can improve the quality of STD reports and syphilis screening as well as its effect of diagnosis and treatment,which is worthy of promotion to the medical institutions.
2017 Vol. 24 (17): 160-162 [Abstract] ( 119 ) HTML (42 KB)  PDF  (0 KB)  ( 39 )
163 Efficacy of feedback teaching method on the exercise compliance and recurrence rate in patients with lumbar intervertebral disci herniation
ZHOU Song-fei;JIN Xiong-jie;ZHAO Jun-ping;ZHANG Chen-yao;PENG Ye
ObjectiveTo explore the efficacy of feedback teaching method on the exercise compliance and recurrence rate in patients with protrasion of the lumbar intervertebral disci.Methods80 patients with protrasion of the lumbar intervertebral disci in our hospital from January 2016 to June 2016 were selected and randomly divided into two groups with computer program,with 40 cases in each group.The control group was given routine nursing,while the observation group used feedback teaching method.The exercise compliance and recurrence rate were compared between two groups.ResultsThe exercise compliance in the observation group(75.00%)was higher than that in the control group(25.00%), the recurrence rate(7.50%)was lower than that in the control group(42.50%),and the differences were statistically significant(P＜0.05).ConclusionFeedback teaching method shows positive effects in enhancing compliance for the lumbar disc herniation patient on training back muscles and reducing the recurrence rate.Feedback teaching method is an effective health education method.
2017 Vol. 24 (17): 163-165 [Abstract] ( 110 ) HTML (44 KB)  PDF  (0 KB)  ( 38 )
166 Application of health education path intervention on the continuing nursing care in patients with PICC
HUANG Rong-qiu;LI Lin-zhi;QIU Yun-hong
ObjectiveTo explore the application of health education path intervention on the continuing nursing care in patients with PICC.Methods200 patients with PICC in our hospital from January 2015 to June 2016 were selected as the research objects and divided into two group according to the random number table,with 100 cases in each group. Patients in the control group were given conventional nursing,while patients in the observation group were given health education path intervention.The self-nursing ability,health behavior,nursing satisfaction and the incidence of adverse reaction were compared between two groups.ResultsBefore intervention,there were no significantly different among the scores of self-nursing ability and health behavior in two groups(P＞0.05);after intervention,the scores of two indexes in two groups were all increased,and compared with those before nursing,the differences were statistically significant(P＜0.05). And those in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The nursing satisfaction in the observation was higher than that in the control group,the incidence of adverse reaction was lower than that in the control group,and the differences were statistically significant(P＜0.05).ConclusionUsing health education path intervention in patients with PICC can improve self-nursing ability,health behavior and nursing satisfaction and can reduce the incidence of adverse reaction.It is worthy of clinical application.
2017 Vol. 24 (17): 166-169 [Abstract] ( 162 ) HTML (40 KB)  PDF  (0 KB)  ( 52 )
170 Comparison of clinical efficacy between laparoscopic cholecystectomy and open cholecystectomy
JIANG Qiao-xia;HUANG Yan-qin;PENG Xiao-jie
ObjectiveTo compare the clinical efficacy between laparoscopic cholecystectomy and open cholecystectomy.Methods84 patients accepted cholecystectomy in our hospital from February 2015 to February 2017 were selected as the research objects and divided into the control group and the observation group according to the different surgery methods,with 42 cases in each group.Patients in the control group were treated with open cholecystectomy(OC),and patients in the observation group were received：laparoscopic cholecystectomy(LC).The surgery situation,the recovery condition after surgery,the incidence of relapse and complication were compared between two groups.ResultsThe operation time,postoperative exhaust time,postoperative activity time,gastrointestinal function recovery time,the length of hospital stays and operative incision lengths were shorter than those in the control group;peroperative bleeding and dosage of analgesicwas less than that in the control group;the incidence of complications (incision hemorrhage,incision infection, radiating pain,obstructive jaundice)were lower than those in the control group,and the differences were statistically significant(P＜0.05).There were no relapses in two groups.ConclusionThe application of laparoscopic cholecystectomy in the treatment of gallbladder disease,combined with the quality of nursing intervention,has a remarkable clinical effect and high safety,so it is worth to be widely used in clinical practice.
2017 Vol. 24 (17): 170-172 [Abstract] ( 117 ) HTML (38 KB)  PDF  (0 KB)  ( 52 )
173 Nursing observation of patients with advanced ovarian cancer treated with paclitaxel combined with cisplatin
HAO Mei-mei
ObjectiveTo explore the nursing of patients with advanced ovarian cancer treated with paclitaxel combined with cisplatin.MethodsA total of 122 patients with advanced ovary treated with cisplatin combined with paclitaxel in our hospital from May 2014 to September 2016 were selected as the objects were divided into the observation group and the control group，with 61 cases in each group.The control group was given conventional nursing,while the obsevation group was given comprehensive humanistic nursing.The clinical effect,the incidence of adverse reaction,anxiety and depression and quality of life were compared between two groups.ResultsThe incidence of clinical effect in the observation group(85.25%)was higher than that in the control group(63.93%),the incidence of adverse reaction,anxiety and depression(3.28%,47.54%,45.90%)were lower than those in the control group(16.39%,77.05%,73.77%),the score of quality of life[(82.32±1.21)points]was higher than that in the control group[(69.76±0.89)points],and the differences were statistically significant(P＜0.05).ConclusionThe comprehensive humanistic nursing intervention can improve the quality of life and psychological comfort of paclitaxel combined with cisplatin in the treatment of advanced ovarian cancer patients,and can reduce the the incidence of adverse reaction,improve the clinical treatment effect.
2017 Vol. 24 (17): 173-175 [Abstract] ( 153 ) HTML (36 KB)  PDF  (0 KB)  ( 59 )
176 Nursing efficacy of comprehensive nursing intervention on patients with acute gastroenteritis
DONG Yu-rong
ObjectiveTo explore nursing efficacy of comprehensive nursing intervention on patients with acute gastroenteritis.MethodsAltogether 50 patients with acute gastroenteritis patients who were treated in our hospital from March 2015 to March 2016 were selected and randomly divided into the control group and the observation group according to the random distribution principle,with 25 cases in each group.Patients in two groups were both treated with conventional therapy,including intestinal infections and regulation of water and electrolyte balance.On the basis of conventional therapy,the control group was given conventional nursing,while the observation group was given comprehensive nursing intervention.The nursing efficacy,length of hospital stays and patients′nursing satisfaction were compared between two groups.ResultsThe total nursing effective rate in the observation group(92.0%)was higher than that in the control group(64.0%),the length of hospital stays[(3.42±1.27)d]was shorter than that in the control group[(7.14±1.14) d],the patients′nursing satisfaction(96.0%)was higher than that in the control group(60.0%),and the differences were statistically significant(P＜0.05).ConclusionComprehensive nursing intervention has better nursing effect for acute gastroenteritis patients,can improve nursing efficacy,shorten length of hospital stays,increase the patients′nursing satisfaction,which makes better recovery of the patients′conditions and can be popularized and applied clinically.
2017 Vol. 24 (17): 176-178 [Abstract] ( 111 ) HTML (37 KB)  PDF  (0 KB)  ( 59 )
179 Efficacy exploration of health education on the treatment compliance and recurrence in patients with alcohol induced mental disorders function
GAN Yu-wen;PAN Xing-hua;ZHENG Yu-ting;PAN Rui-mei
ObjectiveTo explore the efficacy of health education on the treatment compliance and recurrence in patients with alcohol induced mental disorders function.Methods70 patients with alcohol induced mental disorders function in our hospital from July 2013 to July 2015 were selected and randomly divided into the observation group and the control group according to the draw method,with 35 cases in each group.The ontrol group was given routine medical intervention,while the observation group was given health education on the basis of the control group.The psychological states,treatment compliance,recurrence rate and life satisfaction were compared between two groups.ResultsBefore intervention,there were no significantly different among the scores of SAS and SDS in two groups(P＞0.05);after intervention, the scores SAS and SDS in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The treatment compliance in the observation group was better than that in the control group,the recurrence rate was lower than that in the control group,the life satisfaction was higher than that in the control group,and the differences were statistically significant(P＜0.05).ConclusionThe alcohol induced mental disorders treating with health education intervention can improve their psychological state and treatment compliance,reduce the recurrence rate,and the efficacy is significant.It is worthy of clinical application.
2017 Vol. 24 (17): 179-181 [Abstract] ( 122 ) HTML (40 KB)  PDF  (0 KB)  ( 58 )
182 Feasibility analysis of evidence-based nursing care in laparoscopic renal cyst decompression
WANG Ying;CHEN Yi-hua;JIANG Gui-lian;HE Zun-fang;KANG Jing-hua;WANG Si-si
ObjectiveTo explore the efficacy of evidence-based nursing care in laparoscopic renal cyst decompression.Methods74 patients underwent laparoscopic renal cyst decompression in our hospital from August 2014 to September 2016 were selected and randomly divided into the observation group and the control group,with 37 cases in each group. Patients in the observation group were given evidence-based nursing,while patients in the control group were given conventional nursing.The nursing satisfaction,the incidence of complication,the degree of anxiety and depression were compared between two groups.ResultsBefore nursing,there were no significantly different among the scores of SAS and SDS in two groups(P＞0.05);after nursing,the scores SAS and SDS in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The nursing satisfaction in the observation group was higher than that in the control group,the incidence of complication was lower than that in the control group,and the differences were statistically significant(P＜0.05).ConclusionEvidence-based nursing model can be used to reduce the incidence of complications,improve nursing satisfaction,relieve the negative emotions of patients,and be worthy of clinical nursing work in the patients with renal cystectomy and laparoscopic decompression.
2017 Vol. 24 (17): 182-184 [Abstract] ( 125 ) HTML (40 KB)  PDF  (0 KB)  ( 67 )
185 Efficacy of high quality nursing service on multiple thoracic fractures with hemopneumothorax
CHEN Ting
ObjectiveTo explore the efficacy of high quality nursing service on multiple thoracic fractures with hemopneumothorax.Methods80 patients with multiple thoracic fractures with hemopneumothorax in our hospital from June 2015 to January 2017 were selected as the research objects and divided into the observation group and the control group,with 40 cases in each group.The control group was given routine nursing,while the observation group was given high quality nursing.The diifficulty of expectoration,the degree of anxiety and depression,the scores of nursing satisfaction,pain,nursingqualityandenvironmentalwerecomparedbetweentwogroups.ResultsThedifficultyofexpectoration in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05). Before intervention,there were no significant differences among the scores of indexes in SAS,SDS in two groups (P＞0.05);after intervention,the scores of SAS,SDS in two groups were all decreased,and compared with those before intervention,the differences were statistically significant(P＜0.05).And those in the observation group was lower than those in the control group,and the differences were statistically significant(P＜0.05).The scores of nursing satisfaction, pain,nursing quality and environmental in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.01).ConclusionThe quality nursing service has great influence on the multiple thoracic fractures with hemopneumothorax,which can improve the nursing service quality,reduce the negative emotion,relieve the postoperative pain and reduce the difficulty of expectoration.It is worthy of clinical application.
2017 Vol. 24 (17): 185-187 [Abstract] ( 103 ) HTML (38 KB)  PDF  (0 KB)  ( 66 )
188 Application effect of comprehensive nursing care in elderly patients with hypertensive intracerebral hemorrhage
WAN Yong-hong CHEN Xiu-li WANG Jun
ObjectiveTo explore the application effect of comprehensive nursing care in elderly patients with hypertensive intracerebral hemorrhage.MethodsAltogether 44 elderly patients with hypertensive intracerebral hemorrhage who were treated in our hospital from March 2015 to April 2016 were randomly selected and divided into the observation group and the control group,with 22 cases in each group.The observation group was treated with comprehensive nursing care;while the control group was treated with conventional nursing.The length of hospital stays and nursing satisfaction were compared between two groups.ResultsThe length of hospital stays in the observation group[(20.14±1.53)d]was shorter than that in the control group[(27.45±2.07)d],the nursing satisfaction(100.0%)was higher than that in the control group(81.8%),and the differences were statistically significant(P＜0.05).ConclusionComprehensive nursing has very obvious clinical nursing effect in patients with hypertensive cerebral hemorrhage,can shorten the length of stay and improve patients′recovery rate and satisfaction degree,which is worthy of clinical application.
2017 Vol. 24 (17): 188-190 [Abstract] ( 123 ) HTML (35 KB)  PDF  (0 KB)  ( 35 )
191 Application effect of the WeChat platform health education in patients with minimally invasive surgery for kidney stones
CHEN Pei-xia;LIN Xiao-hua;XU Ying-hua;LIANG Jian-qi
ObjectiveTo explore the application effect of the WeChat platform health education in patients with minimally invasive surgery for kidney stones.Methods100 patients with kidney stones in our hospital from January 2016 to January 2017 were selected and randomly divided into the observation group and the control group according to the random number table,with 50 cases in each group.The control group was given routine nursing,while the observation group was given the WeChat platform health education on the basis of the control group.The nursing satisfaction,awareness of nursing knowledge and kidney disease were compared between two groups.ResultsThe nursing satisfaction,awareness of nursing knowledge and kidney disease(96.00%,96.00%,98.00%)were higher than those in the control group (80.00%,88.00%,72.00%),and the differences were statistically significant(P＜0.05).ConclusionHealth education can improve the WeChat platform of patients with kidney calculi in minimally invasive surgery for renal calculi continuation degree of nursing knowledge master the nursing of minimally invasive surgery,understanding of kidney disease and the health education satisfaction has guiding significance for clinical.
2017 Vol. 24 (17): 191-193 [Abstract] ( 139 ) HTML (42 KB)  PDF  (0 KB)  ( 70 )
194 Application of cluster nursing in the prevention of aspiration in severe patients in Department of Respiratory Medicine
QIN Xiao-hui;SHE Li-jun;HUANG Pei-ming;LIANG Hui
ObjectiveTo explore the application of cluster nursing in the prevention of aspiration in severe patients in Department of Respiratory Medicine.Methods48 severe patients from January to December 2016 and 41 severe patients from January to December 2015 in Department of Respiratory Medicine in our hospital were selected respectively as the observation group and the control group.Patients in the control group were given the routine nursing,while patients in the observation group were given the cluster nursing on the basis of the control group.The incidence of aspiration,the length of hospital stays,the incidence of ICU treatment and the level of anxiety were compared between two groups.ResultsThe incidence of aspiration and ICU treatment in the observation group were lower than that in the control group,the length of hospital stays was shorter than that in the control group,and the differences were statistically significant(P＜0.05).Before nursing,there were no significantly different among the scores of SAS in two groups(P＞0.05); after nursing,the scores of SAS in two groups were all declined,and compared with those before nursing,the differences were statistically significant(P＜0.01).And that in the observation group was higher than that in control group,and the difference was statistically significant(P＜0.01).ConclusionThe cluster nursing has a positive effect on the prevention of aspiration in severe patients in respiratory medicine,which can effectively reduce the incidence of aspiration,significantly shorten the length of hospital stay,reduce the incidence of ICU treatment and the patients′anxiety.It is worthy of clinical application and promotion.
2017 Vol. 24 (17): 194-196 [Abstract] ( 149 ) HTML (38 KB)  PDF  (0 KB)  ( 60 )
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