深度、中度和浅度麻醉对老年全身麻醉患者术后认知功能的影响对比

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Abstract ObjectiveTo explore the influence of depth,moderate and superficial anesthesia on postoperative cognitive function in elderly patients undergoing general anesthesia.Methods69 elderly patients scheduled to undergo elective gastrointestinal tumor surgery under general anesthesia in our hospital from February 2014 to February 2017 were selected and randomly divided into group L,group M and group D,23 cases in each group.Group L was given superficial anesthesia,group M was given moderate anesthesia,and group D was given deep anesthesia.The time of anesthesia,the amount of fluid infusion,the amount of bleeding,the recovery time of the directional force,the heart rate (HR),the mean arterial pressure (MAP),the incidence rate of POCD and the MMSE score before and after the operation were compared between the three groups.ResultsThere was no significant difference in the time of anesthesia,the amount of fluid infusion and the amount of bleeding between the three groups (P＞0.05).The recovery time of directional force in group D was significantly longer than that in group L and group M,with significant difference(P＜0.05).The level of HR,MAP before intubation,1 hour and 2 hours during the operation in group D were significantly lower than those in group L and group M,with significant difference (P＜0.05).There was no significant difference in the level of HR and MAP after the restoration of the directional force at 30 min between the three groups(P＞0.05).The level of HR and MAP before intubation, 1 hour and 2 hours during the operation in the three groups were significantly lower than those before induction,with significant difference(P＜0.05).The incidence rate of POCD at 24 hours and 48 hours after operation in group D was significantly lower than that in group L and group M,with significant difference(P＜0.05).The incidence rate of POCD at 24 hours and 48 hours after operation in group M was significantly lower than that in group L,with significant difference (P＜0.05).The MMSE scores at 1 week after operation in the three groups was significantly lower than that before the operation,with significant difference(P＜0.05).The MMSE score at 3 months after operation in group L and group M was lowerthan that before operation,with significant difference(P＜0.05).There was no significant difference in MMSE score in group D between before operation and at 3 months after operation(P＞0.05).ConclusionFor elderly patients with general anesthesia,deep anesthesia can effectively reduce the incidence rate of POCD in elderly patients,compared with other depth of anesthesia,the patient′s cognitive function will be less affected.

Key words： Depth of anesthesia Cognitive function General anesthesia

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	WANG Jing
	SHI Lei
	TIAN Xian-shu

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WANG Jing,SHI Lei,TIAN Xian-shu. Comparison of the influence of depth,moderate and superficial anesthesia on postoperative cognitive function in elderly patients undergoing general anesthesia[J]. 中国当代医药, 2017, 24(17): 120-123.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I17/120

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