糖尿病性心肌病患者HOMA-IR、HbA1c与hs-cTnT的关系

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Abstract ObjectiveTo investigate the relationship between insulin resistance index(HOMA-IR),glycosylated hemoglobin (HbA1c)and high-sensitivity troponin T(hs-cTnT)in patients with diabetic cardiomyopathy.Methods100 patients with diabetic cardiomyopathy from January to October in 2016 in our hospital were selected as the diabetic cardiomyopathy group,100 patients with simple diabetes mellitus at the same time were enrolled as the simple diabetes mellitus group, the Pearson correlation analysis was used to analyzed the relationship between HOMA-IR,HbA1c and hs-cTnT,the level of HOMA-IR,HbA1c and hs,cTnT of all patients were analyzed.ResultsThe levels of HOMA-IR,HbA1c and hs-cT-nT in the diabetic cardiomyopathy group was higher than that in the simple diabetes mellitus group,with significant difference (P＜0.05).The results of the Pearson correlation analysis showed that,HOMA-IR and HbA1c were positively related to hs-cTnT(P＜0.05).When HOMA-IR took 2.85 as the critical value,HbA1c took 7.35%as the critical value,and hs-cTnT took 0.28 as the critical value,the positive predictive value,negative predictive value and accuracy of the three combined detection methods for predicting diabetic cardiomyopathy were 93.20%,95.88%,94.50%,respectively,and the actual results were basically the same,the difference was not statistically significant(P＞0.05).ConclusionThe levels of HOMA-IR and HbA1c in diabetic patients are related to myocardial injury,The combined detection of HOMA-IR, HbA1c and hs-cTnT levels may be an important reference marker for predicting the occurrence of diabetic cardiomyopathy,it is worthy of further clinical promotion.

Key words： Diabetic cardiomyopathy Insulin resistance index Glycosylated hemoglobin High-sensitivity troponin

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	LIN Jian

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LIN Jian. Relationship between HOMA-IR,HbA1c and hs-cTnT in patients with diabetic cardiomyopathy[J]. 中国当代医药, 2017, 24(17): 48-50.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I17/48

[1]	余进胜，贺勇锋，杨粟毅.心血管疾病高敏肌钙蛋白、心肌酶谱测定分析[J].中外医学研究，2011，9（29）：5-7.
[2]	陆菊明.中国2型糖尿病防治指南（2013年版）更新要点的解读[J].中国糖尿病杂志，2014，22（10）：865-869.
[3]	镡海霞.糖尿病性心肌病的临床特点及治疗[J].中国民族民间医药，2013，22（7）：62-63.
[4]	杨春丽，汪连香，练柳丁.通心络胶囊辅助治疗糖尿病心肌病的疗效观察[J].现代医院，2015，15（2）：57-59.
[5]	王玲玲，李敏，李晓琳.Fas/FasL对糖尿病心肌病的影响[J].中国当代医药，2015，22（18）：14-16.
[6]	梁潇，潘大彬.线粒体功能障碍对糖尿病心肌病发病进展的影响[J].国际老年医学杂志，2015，36（1）：46-48，封3.
[7]	Goyal BR，Mehta AA.Diabetic cardiomyopathy pathophysiologicalmechanisms and cardiac dysfuntion[J].Hum Exp Toxicol，2013，32（6）：571-590.
[8]	刘丹.TRB3、肿瘤坏死因子-α与糖尿病性心肌病的关系初探[J].中华肿瘤防治杂志，2015，22（22）：49-50.
[9]	吴铿，游琼，李腾，等.糖尿病心肌病患者外周血单个核细胞E26转录因子1的表达及其意义[J].中国医药，2013，8（9）：1238-1240.
[10]	吴献贤，秦玮，张勇.他汀类药物治疗糖尿病心肌病微血管病变的研究进展[J].中国医药科学，2015，5（7）：29-34.
[11]	Palomer X，Salvadó L，Barroso E，et al.An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy[J].Int J Cardiol，2013，168（4）：3160-3172.
[12]	苏仕月，李结华，宗晓娜.脂联素及脂联素受体1的表达与糖尿病心肌病的关系[J].中国循证心血管医学杂志，2014，6（5）：562-564.
[13]	祝炜，徐全胜，王超，等.通心络辅治对糖尿病心肌病患者血液流变学及心肌耗氧量的影响[J].疑难病杂志，2013，12（7）：538-539.
[14]	Pappachan JM，Varughese GI，Sriraman R，et al.Diabetic cardiomyopathy：pathophysiology，diagnostic evaluation and management[J].World J Diabetes，2013，4（5）：177-189.
[15]	孙佩佩，王霞，俞淑静，等.糖尿病性心肌病患者血清cox-2水平变化及早期药物干预研究[J].泰山医学院学报，2015，36（11）：1215-1217.