慢性肾脏病患者活性维生素D3与颈动脉粥样硬化的相关性研究

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Abstract ObjectiveTo investigate the relationship between active vitamin D3,micro-inflammation and carotid atherosclerosis in patients with chronic kidney disease(CKD),and whether active vitamin D3 could improve carotid atherosclerosis and the possible mechanism.Methods96 non-dialysis patients diagnosed as CKD in our hospital from July 2014 to July 2015 were divided into three groups according to the glomerular filtration rate(GFR),group A was CKD3 stage,group B was CKD4 stage,group C was CKD5 stage,and each group had 32 cases.Each group was given Calcitriol of 0.25 μg/d for 1 year.25 hydroxyvitamin D3[25(OH)2D3],hypersensitivity C reactive protein(hs-CRP)and carotid intima-media thickness(IMT)before and after treatment in the three groups were measured.Results25(OH)2D3was decreased,hs-CRP increased and IMT decreased before treatment in the three groups which was associated with the progress of CKD,then after Calcitriol treatment,hs-CRP and IMT decreased (P＜0.05).The decrease degree of hs-CRP and IMT was positively correlated with the increase of 25(OH)2D3(P＜0.05).Conclusion5(OH)2D3level and micro-inflammatory status are the factors of carotid atherosclerosis in patients with CKD,Calcitriol can improve carotid atherosclerosis by improving the Micro inflammation.

Key words： Chronic kidney disease Active vitamin D3 Carotid atherosclerosis Carotid intima-media thickness Microinflammation

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	Articles by authors
	LAI Yu-ping
	ZHANG Zhou
	LIANG Yan-juan
	YOU Yong-sen

Cite this article:

LAI Yu-ping,ZHANG Zhou,LIANG Yan-juan, et al. Correlation study of active vitamin D3and carotid atherosclerosis in patients with chronic kidney disease[J]. 中国当代医药, 2017, 24(17): 45-47.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I17/45

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