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2021 Vol. 28, No. 34 Published: 2021-12-08

	4	Effect of extract of Begonia Fimbristipula on the vascular inflammation of diabetic mices
		LIU Si-yu; LI Yi ;TAN Hui ;HUANG Tian ;ZHANG Yu-qin ;GU Bin▲
		Objective To observe the effect of extract of Begonia Fimbristipula on the vascular inflammation of diabetic mices. Methods A total of 60 healthy Kunming mice from June to August in 2019 were selected as the research objects. Six mice were randomly selected as normal control group and fed with normal diet. The other 54 mice were fed with high sugar and high fat diet for one month and induced by low-dose streptozotocin (STZ). Mice without successful modeling (blood glucose <11.0 mmol/L) were excluded, and the remaining successful modeling mice were divided into diabetic model group, different doses of Begonia Fimbristipula extract group and Metformin-positive control group, with 6 mice in each group. The extract group was given 0.75, 1.5 and 3 g/kg intragastric administration, the Metformin group was given 150 mg/kg intragastric administration, and the diabetic model group was given normal saline intragastric administration. After 4 weeks, fasting blood glucose, body weight and oral glucose tolerance were compared. The contents of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in serum of mice in each group were compared by enzyme-linked immunosorbent assay (ELISA). The expressions of IL-1β, TNF-α and IL-10 in thoracic aorta of mice were compared by real-time fluorescence quantitative PCR. Results At the end of the experiment, blood glucose, area under oral glucose tolerance curve, contents of IL-1β and TNF-α in serum and mRNA expression of IL-1β and TNF-α in vascular tissue in diabetic model group were higher than those in normal control group, and the differences were statistically significant (P<0.05). The body weight, serum IL-10 content and IL-10 mRNA expression in vascular tissues of dia-betic model group were lower than those of normal control group, and the differences were statistically significant (P<0.05). After the experiment, blood glucose, area under blood glucose curve, contents of IL-1β and TNF-α in serum and mRNA expression of IL-1β and TNF-α in vascular tissue in 1.5 and 3 g/kg Begonia Fimbristipula extract group and Metformin group were lower than those in diabetic model group, and the differences were statistically significant (P<0.05). The body weight, serum IL-10 content and IL-10 mRNA expression in blood vessels of mice in 1.5 and 3 g/kg Begonia Fimbristipula extract group and Metformin group were higher than those in diabetic model group, and the differences were statistically significant (P<0.05). Conclusion Extract of Begonia Fimbristipula can inhibit the production of vascular inflammation in diabetic mices.
		2021 Vol. 28 (34): 4-8 [Abstract] ( 44 ) HTML (39 KB) PDF (0 KB) ( 8 )

	9	Study on the mechanism of the active ingredients of Mongolian medicine Alagabanbu on HepG2 cells
		MA Shi-qi;DENG Xiu-ling; WU Ya-nan; HAN Jing-jing;ZHAO Yang;QIAO Yi-yun;WANG Hai-sheng▲
		Objective To investigate the molecular mechanism of anticancer effect of cantharidin (CTD), the active ingredient of Mongolian medicine Alagabanbu on liver cancer. Methods CTD extracted by the research group was used to study the effect of CTD on the proliferation, apoptosis, cycle and other cell functions of HepG2 cells. Transcriptome sequencing was used to study the effect on mRNA gene expression of HepG2 cells. Results MTT results showed that the inhibition of HepG2 cell proliferation by CTD was dose-time dependent. Flow cytometry analysis results showed that cantharidin can induce cell cycle arrest in G2/M phase, and Caspase 3/7 fluorescence detection experiments confirmed that it can induce HepG2 cell apoptosis. Bioinformatics analysis after transcriptome sequencing, screened out 18 significantly differentially expressed mRNA genes. Conclusion CTD of Alagagambula extract can promote apoptosis and contact cell cycle arrest to inhibit hepatocellular carcinoma cells, and further affect the biological behavior of HepG2 by affecting the differential expression of mRNA genes, which may be a target for the early prediction and treatment of hepatocellular carcinoma.
		2021 Vol. 28 (34): 9-12 [Abstract] ( 40 ) HTML (38 KB) PDF (0 KB) ( 5 )

	13	Expression of microRNA-365 and correlation with blood pressure and left ventricular mass index in the plasma of patients with hypertensive myocardial hypertrophy
		ZHOU Xu-feng;ZOU Liang-ying; HUANG He; ZHONG Wen-ting;WANG Bei
		Objective Analysis the expression of microRNA-365 (miRNA-365) and correlation with blood pressure and left ventricular mass index in the plasma of patients with hypertensive myocardial hypertrophy. Methods A total of 100 patients with hypertension admitted to the First Affiliated Hospital of Gannan Medical University from June 2020 to February 2021 were selected as the research subjects, patients with hypertension complicated with left ventricular hypertrophy were divided into observation group (50 cases), patients with simple hypertension were divided into control group 2 (50 cases), and 50 healthy subjects who underwent physical examination at the same period were selected as control group 1. Ambulate blood pressure, clinic blood pressure and color doppler echocardiography were performed in all three groups. The expression of circulating miRNA-365 was detected by reverse transcription polymerase chain reaction (RT-PCR), and the correlation between miRNA-365 expression level and blood pressure parameters and left ventricular mass index was analyzed. Results The dynamic blood pressure, daytime blood pressure, clinic blood pressure and left ventricular mass index of the observation group were higher than those of control group 1 and control group 2, the differences were statistically significant (P<0.05). The expression level of miRNA-365 in observation group(1.22±0.31) was higher than that in control group 1 (0.84±0.16) and control group 2 (1.02±0.27), the differences were statistically significant (P<0.05). Pearson analysis showed that miRNA-365 expression was positively correlated with ambulate blood pressure (24 h mean systolic pressure, 24 h mean diastolic pressure, 24 h mean pulse pressure) and left ventricular mass index (P<0.05). There was no significant correlation with daytime blood pressure (daytime systolic blood pressure, daytime diastolic blood pressure, daytime pulse pressure) and office blood pressure (office systolic blood pressure, office diastolic blood pressure, office pulse pressure) (P>0.05). Conclusion miRNA-365 is positively correlated with ambulatory blood pressure and left ventricular mass index in patients with hypertensive myocardial hypertrophy disease, detection of miRNA-365 expression in plasma can assist in the diagnosis of hypertensive myocardial hypertrophy.
		2021 Vol. 28 (34): 13-16 [Abstract] ( 33 ) HTML (36 KB) PDF (0 KB) ( 8 )

	17	Correlation between untreated period and therapeutic effect of firstepisode schizophrenia
		JIAO Feng
		Objective To explore the correlation between the untreated period of first episode schizophrenia and the treatment effect. Methods A total of 60 patients with first-episode schizophrenia admitted to Ji An Third People′s Hospital from September 2020 to March 2021 were selected as the research subjects, and the schizophrenia first-onset symptom rating scale (SOS) was used to assess the untreated period (DUP) upon admission, with the median DUP of 24 weeks as the dividing line, and the patients were divided into short DUP group (n=24, Median DUP ≤24 weeks) and long DUP group (n=36, median DUP>24 weeks). The serological indicators, positive and negative syndrome scale(PANSS) scores, and clinical global impression (CGI) scores were compared between the two groups. Results The serum creatine kinase isoenzymes (CK), creatine kinase isoenzymes (CK-MB), and lactate dehydrogenase (LDH-L) levels in the short DUP group on admission were lower than those in the long DUP group, and the differences were statistically significant (P<0.05); the CK, CK-MB, and LDH-L in the two groups at discharge were lower than those before treatment, and the CK, CK-MB, and LDH-L in the short DUP group were lower than those in the long DUP group, the differences were statistically significant (P<0.05). The PANSS score and the severity of illness (SI) score of the CGI scale in the short DUP group at admission were lower than those in the long DUP group, and the differences were statistically significant (P<0.05); the PANSS score and SI score of the CGI scale in the two groups at discharge were lower than those before treatment, and the PANSS score and the SI score, global improvement (GI) score and efficacy index (EI)score of the CGI scale in the short DUP group were lower than those in the long DUP group, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that DUP was positively correlated with PANSS score, CGI score, CK, CK-MB, and LDH-L (P<0.05). Conclusion As the untreated period of first-episode schizophrenia is prolonged, its therapeutic effect is significantly reduced. Early treatment should be paid attention to to improve its efficacy, inhibit or delay disease progression, and reduce mental symptoms.
		2021 Vol. 28 (34): 17-21 [Abstract] ( 49 ) HTML (40 KB) PDF (0 KB) ( 7 )

	22	Clinical effect of modified closed mouth impression and biological functional system for complete denture repair in mandibular edentulous patients with low flat alveolar ridge
		TIAN Ju-zhong ;XU Qing-feng
		Objective To observe and evaluate the clinical effect of modified closed mouth impression method and biological functional system (BPS) for complete denture in edentulous patients with severe alveolar ridge absorption.Methods From March 2016 to March 2019, a total of 41 edentulous patients with severe mandibular alveolar ridge absorption in Department of Stomatology, Changzhou Second People′s Hospital were selected as research objects and divided into observation group (n=21) and control group (n=20) according to random number table method. The observation group performed complete denture repair using the modified closed mouth impression method, and the control groups performed complete denture repair using the BPS. The subjective satisfaction and masticatory efficiency at 3 and 6 months after repair were compared between the two groups. Results There was no statistically significant difference of subjective satisfaction between the two groups (P＞0.05). At 3 and 6 months after repair, there were no statistically significant differences of masticatory efficiency between the two groups or in the group (P＞0.05). Conclusion Both the modified closed mouth impression method and BPS method can achieve good restoration effect of complete denture.However, the improved closed mouth impression method has easy equipment requirements, lower technical sensitivity and the fewer steps. For patients with severe absorption of mandibular alveolar crest, it has good clinical efficacy and can be used as a conventional printing method for total denture repair.
		2021 Vol. 28 (34): 22-25转30 [Abstract] ( 39 ) HTML (40 KB) PDF (0 KB) ( 8 )

	26	Research progress of human amniotic membrane dressing in wound treatment
		JIANG Min-jun; ZHANG Ju; LAI Dan-hui
		Amniotic membrane is rich in growth factors and collagen. It has the advantages of accelerating wound healing, reducing wound infection, reducing immune rejection, reducing scar formation and relieving wound pain. Therefore,it can be used for the treatment of various wounds in clinic. At present, common uses of amniotic membrane dressing include the treatment of diabetic foot ulcers, severe burns, oral surgery, and eye injuries. Amniotic membrane dressing has great potential for wound treatment. With the development of medical technology, amniotic membrane and its derivatives will make greater breakthroughs in the field of wound treatment.
		2021 Vol. 28 (34): 26-30 [Abstract] ( 45 ) HTML (43 KB) PDF (0 KB) ( 9 )

	31	Application progress of virtual reality technology in the rehabilitation of children with cerebral palsy
		HUANG Li-juan;YANG Liu; REN Jun-li;ZHOU Xiao-ying;LI Yan; LI Hai-hong
		Traditional cerebral palsy rehabilitation treatment for children mainly includes Hyperbaric Oxygen Therapy,Acupuncture, Massage Therapy, Neurodevelopment Promotion Technology, Compulsory Induced Exercise Therapy,Transcranial Direct Current Stimulation, etc. The comprehensive application of these rehabilitation methods can greatly improve the motor and cognitive impairments of children with cerebral palsy, and improve their basic social adaptability and self-care ability in daily life. However, these rehabilitation methods have limited impact on the children's space and cognitive abilities, and the children are not proactive in cooperation. In recent years, as a new rehabilitation treatment technology, virtual reality technology is widely used in various kinds of disease rehabilitation, and the application of virtual reality technology in the field of rehabilitation of children with cerebral palsy is also increasing. This paper briefly discusses the current situation of virtual reality technology, the application of virtual reality technology in the sports rehabilitation of children with cerebral palsy, and puts forward the limitations of the existing research, aiming to better help the clinical workers and researchers in the field of cerebral palsy rehabilitation to understand the current situation and prospects of virtual reality technology application, so as to better carry out the rehabilitation care of children with cerebral paralysis.
		2021 Vol. 28 (34): 31-34 [Abstract] ( 49 ) HTML (37 KB) PDF (0 KB) ( 9 )

	35	Clinical effect of endoscopic mucosal dissection combined with endoscopic band ligation in the treatment of small gastric stromal tumors
		XU Huan; WANG Juan ;YE Xiang-rong▲
		Objective To explore the clinical effect of endoscopic mucosal dissection combined with endoscopic band ligation in the treatment of small gastric stromal tumors. Methods Fifty-six patients with small gastric stromal tumors admitted to the Affiliated Hospital of Jiujiang University from January 2017 to March 2020 were selected as the research objects, and were divided into a control group (n=28) and an observation group (n=28) by random paper method，the control group was treated with endoscopic mucosal resection, and the observation group was treated with endoscopic mucosal dissection combined with endoscopic band ligation. The clinical indicators, clinical efficacy, and prognosis of the two groups of patients were compared. Results The intraoperative blood loss of the observation group was less than that of the control group, the hospital stay was shorter than that of the control group, the operation time was longer than that of the control group, and the area of lesion resection was larger than that of the control group, the differences were statistically significant (P<0.05). The overall resection rate and curative resection rate in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the rate of gastric perforation or gastric bleeding, recurrence rate, liver metastasis rate,and mortality rate between the two groups (P>0.05). Conclusion Endoscopic mucosal dissection combined with endoscopic band ligation for the treatment of small gastric stromal tumors has small trauma, quick recovery and good prognosis.
		2021 Vol. 28 (34): 35-38 [Abstract] ( 35 ) HTML (35 KB) PDF (0 KB) ( 7 )

	39	Clinical effect of Yiqi Yangyin Tongmai Decoction combined with Clopidogrel in the treatment of elderly patients with myocardial infarction and its influence on myocardial enzymes
		ZHAO Mo ;XING Jin ;LI Li
		Objective To study the clinical effect of Yiqi Yangyin Tongmai Decoction combined with Clopidogrel in the treatment of elderly patients with myocardial infarction and its influence on myocardial enzymes. Methods A total of 107 cases of elderly patients with myocardial infarction in Fushun Hospital of traditional Chinese Medicine from January 2018 to January 2021 were selected as the research objects and divided observation group (54 cases) and control group (53 cases). The control group was treated with Clopidogrel, and the observation group was treated with Yiqi Yangyin Tongmai Decoction combined with Clopidogrel. The clinical efficacy, myocardial enzymes, hemorheology and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment, the levels of cardiac troponin T (cTnT) and creatine kinase MB (CK-MB) in the observation group were lower than those in the control group, and the levels of cardiotrophin 1 (CT-1) in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The hemorheological indexes including high shear whole blood viscosity (HBV), medium shear whole blood viscosity (MBV) and low shear whole blood viscosity (LBV) in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was statistical significance in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Yiqi Yangyin Tongmai Decoction combined with Clopidogrel has good curative effect on elderly patients with myocardial infarction, reduces the index level of myocardial injury, improves the hemorheological state of the body, and has good safety, which can be recommended clinically.
		2021 Vol. 28 (34): 39-42 [Abstract] ( 38 ) HTML (36 KB) PDF (0 KB) ( 7 )

	43	Effect of Probucol combined with Rosuvastatin on inflammatory mediators and related laboratory indexes in patients with cerebral infarction ZHANG Yi-dan XU Chu-chuan YU Zi-wen LIU Lin
	Effect of Probucol combined with Rosuvastatin on inflammatory mediators and related laboratory indexes in patients with cerebral infarction ZHANG Yi-dan XU Chu-chuan YU Zi-wen LIU Lin [J]. 中国当代医药, 2021,28(34): 43-45转53')" href="#">	ZHANG Yi-dan; XU Chu-chuan ;YU Zi-wen; LIU Lin
		Objective To explore the effect of Probucol combined with Rosuvastatin on inflammatory mediators and related laboratory indicators in patients with cerebral infarction. Methods A total of 106 patients with cerebral infarction admitted to the First Affiliated Hospital of Xiamen University from December 2019 to February 2021 were selected and divided into control group (53 cases) and observation group (53 cases) according to the random number table method.The control group was treated with Rosuvastatin, and the observation group was treated with Probucol on the basis of the control group. The inflammatory mediators, serum neuron-specific enolase (NSE), central nervous system-specific protein (S100β), human chitinase protein 40 (YKL-40) and blood lipid levels were compared between the two groups.Results After treatment in the observation group, tumor necrosis factor-α (TNF-α), procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and matrix metalloproteinase 9 (MMP-9) level were lower than those in the control group, the levels of NSE, S100β, and YKL-40 were lower than those in the control group, and the levels of total cholesterol (TG), total cholesterol (TC), and low-density lipoprotein (LDL-C) were lower those in the control group, high-density lipoprotein (HDL-C) was higher than that in the control group, the differences were statistically significant (P<0.05); the difference between the two groups of adverse reactions was not statistically significant (P>0.05). Conclusion Probucol combined with Rosuvastatin treatment in patients with cerebral infarction can effectively reduce inflammation, reduce nerve damage, regulate blood lipid levels, and promote neurological function improvement.It is safe and reliable.
		2021 Vol. 28 (34): 43-45转53 [Abstract] ( 45 ) HTML (32 KB) PDF (0 KB) ( 9 )

	46	Application effect of health management platform model based on Internet technology in discharged patients with cardiovascular disease
		CAO Huan ;XIONG Qi
		Objective To explore the application effect of health management platform model based on Internet technology in discharged patients with cardiovascular disease. Methods A total of 286 discharged patients with cardiovascular disease admitted to the First People′s Hospital of Jiujiang City from September 2019 to September 2020 were selected as the research objects. The patients were divided into the observation group and the control group by random number table method, with 143 cases in each group. The observation group was given the Internet technical support health management method, while the control group was given the routine health management method. The mastery of health knowledge, the fasting blood glucose, total cholesterol, systolic blood pressure, body mass index (BMI) and number of smoking roots per day before and after health management, total incidence of adverse cardiovascular events and re-hospitalization rate during follow-up were compared between the two groups. Results The mastery rate of disease knowledge, risk factors, reasonable diet, regular exercise and compliance with medical medicine in observation group were higher than those in control group, and the differences were statistically significant (P<0.05). There were no statistically significant differences in BMI, number of smoking roots per day, fasting blood glucose, total cholesterol and systolic blood pressure between the two groups before management (P>0.05). After management, the levels of BMI, fasting blood glucose, total cholesterol and systolic blood pressure in observation group were lower than those in control group, and the daily number of smoking roots was lower than that in control group, the differences were statistically significant (P<0.05). Within 6 months of follow-up, the total incidence of cardiovascular adverse events and re-hospitalization rate in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The health management platform model supported by Internet technology can significantly improve the mastery of health knowledge of discharged patients with cardiovascular diseases, control risk factors and reduce the occurrence of adverse cardiovascular events, which is worthy of promotion.
		2021 Vol. 28 (34): 46-49 [Abstract] ( 52 ) HTML (35 KB) PDF (0 KB) ( 7 )

	50	Effect of body surface electrocardiogram on location of infarcted artery in patients with acute inferior wall myocardial infarction
		HE Hui-jian ;LIU Ya-ling ;CHEN Ming ;LI Yi ;WU Hai-zhen
		Objective To analyze the role of surface electrocardiogram in the location of infarcted artery in patients with acute inferior myocardial infarction, in order to provide basis for the optimization of the diagnosis and treatment of patients with acute inferior myocardial infarction. Methods A total of 50 patients with acute inferior myocardial infarction treated in Yichun Hospital of Traditional Chinese Medicine from June 2019 to May 2020 were selected as the research subjects, all selected patients underwent surface electrocardiogram and coronary angiography (CAG),the results of CAG were used as the"gold standard"to analyze the evaluation value of each parameter index of surface electrocardiogram in the location of infarcted artery in patients with acute inferior myocardial infarction. Results Among 50 patients with acute inferior myocardial infarction confirmed by CAG, 39 cases had right coronary artery infarction, accounting for 78.00%, 11 cases had left circumflex branch, accounting for 22.00%. The results of Kappa confirmed that there was a good consistency between the results of electrocardiogram and CAG in the location of infarcted artery in patients with acute inferior myocardial infarctio (Kappa=0.781, P<0.05). The surface electrocardiographic findings of left circumflex artery infarction: STaVR↓≥0.05 mV, STV3↓/STⅢ↑>1.2, electrocardiographic findings of right coronary artery: STⅢ↑/STⅡ↑>1, STaVL↓/STⅠ↓>1, STV1↑. The detection rate of STaVR↓≥0.05 mV to left circumflex coronary artery was 90.91%, the detection rate of STV3↓/STⅢ↑>1.2 was 81.82%, the detection rates of STⅢ↑/STⅡ↑>1,STaVL↓/STⅠ↓>1, STV1↑ to right coronary artery infarction were 94.87%, 92.31% and 92.31%, respectively. The detection rates of STⅢ/STⅡ↑>1, STaVL↓/STⅠ↓>1 and STV1↑ were 88.00%, 84.00% and 92.00%, respectively.Conclusion Surface electrocardiogram has high diagnostic efficiency in locating infarct artery in acute inferior myocardial infarction, clinically, the parameters of surface electrocardiogram can be used to assist in locating the infarcted artery, which can provide the basis for the formulation of early treatment regimen.
		2021 Vol. 28 (34): 50-53 [Abstract] ( 42 ) HTML (33 KB) PDF (0 KB) ( 6 )

	54	Pharmaceutical study on intravenous thrombolysis of alteplase in acute cerebral infarction
		ZHENG Peng-yu; JIANG Shun-fu ;BAI Wen-ting ;WANG Jing-yan ;YAN Fei ;WANG Lu ;ZHANG Hai-rong
		Objective To explore the clinical effect of Alteplase intravenous thrombolysis in the treatment of acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction treated in the First People′s Hospital of Jingdezhen City were enrolled between February 2019 and January 2021. They were divided into the observation group and the control group according to random number table method, with 50 cases in each group. The control group was treated with Urokinase thrombolysis, while the observation group was treated with Alteplase intravenous thrombolysis. The scores of National Institutes of Health stroke scale (NIHSS) before and after treatment, the occurrence of secondary hemorrhage and death between the two groups were compared. Results At 7 d and 3 months after treatment,NIHSS score in observation group was lower than that in control group, and the difference was statistically significant(P<0.05). The incidence of hemorrhage and death within 3 months after treatment in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application of Alteplase intravenous thrombolysis in patients with acute cerebral infarction can significantly improve nerve function,with good long-term prognosis. And it can reduce the incidence of hemorrhage and death.
		2021 Vol. 28 (34): 54-56转60 [Abstract] ( 37 ) HTML (33 KB) PDF (0 KB) ( 7 )

	57	Application effect of seamless emergency mode in patients with acute cerebral infarction
		LONG Jian-hua; LI He;LIU Hui-qing; GONG Xin
		Objective To explore the application effect of seamless emergency mode in patients with acute cerebral infarction. Methods A total of 82 patients with acute cerebral infarction admitted to the Hu′nan Provincal People′s Hospital from December 2019 to December 2020 were selected as the research objects, 41 patients admitted during the routine emergency mode from December 2019 to June 2020 were selected and set as the control group, 41 patients admitted during the seamless emergency mode from July to December 2020 were set as the observation group. The first aid efficiency, neurological deficit and prognosis were compared between the two groups. Results The observation group′s time for diagnosis, referral, and thrombolysis after admission were shorter than those of the control group, and the differences were statistically significant (P<0.05). The scores of the national institutes of health stroke scale (NIHSS)were compared between the two groups at the time of admission, the difference was not statistically significant (P>0.05);the NIHSS scale score of the two groups was lower when they were discharged from the hospital, and the observation group was lower than the control group, the differences were statistically significant (P<0.05). The observation group was discharged for 3 months the scores of hand function, strength, mobility, communication, emotion, ability of daily living, memory and thinking, and participation were all higher than those of the control group, and the differences were statistically significant (P<0.05). Conclusion The seamless emergency mode is used in patients with acute cerebral infarction, which is beneficial to shorten the emergency time and reduce the degree of neurological deficits in patients,so as to obtain a good prognosis.
		2021 Vol. 28 (34): 57-60 [Abstract] ( 51 ) HTML (34 KB) PDF (0 KB) ( 5 )

	61	Application of Jinshuibao Capsules in hyperchloremia in patients with severe stroke
		ZENG Ying ;GAO Lin ;CHEN Yong; ZHU Qiu-yan
		Objective To investigate the effect of Jinshuibao Capsules on renal function of patients with severe stroke combined with hypernatremia and hyperchloremia. Methods A total of 148 patients with severe stroke admitted to People′s Hospital of Yichun City from March 2018 to December 2020 were selected as the research objects, including 72 patients with hypernatremia and hyperchloremia and 76 patients without hypernatremia and hyperchloremia. In addition, 72 patients with hypernatremia and hyperchloremia were divided into group A (36 cases) and group B (36 cases)by random number table method. Seventy-six patients without hypernatremia hyperchloremia were divided into group C(38 cases) and group D (38 cases) by random number table method. Patients in group A and group C were treated with conventional comprehensive treatment, while patients in group B and group D were treated with Jinshuibao Capsules.Neurological function and renal function were compared between the four groups. Results Before treatment, there were no statistically significant differences in neurological function between group B and A, group D and C, group B and D,group A and C (P>0.05). After treatment, the scores of National Institutes of Health stroke scale (NIHSS) and modified Rankin scale (mRS) in four groups were lower than those before treatment, and the Glasgow coma (GCS) scores were higher than those before treatment, and the differences were statistically significant (P<0.05). After treatment, NIHSS score and mRS score of group B were lower than those of group A, GCS score was higher than that of group A, the differences were statistically significant (P<0.05). After treatment, NIHSS score and mRS score in group D were lower than those in group C, and GCS score was higher than that in group C, the differences were statistically significant (P<0.05).After treatment, NIHSS score and mRS score of group B were higher than those of group D, GCS score was lower than that of group D, NIHSS score and mRS score of group A were higher than those of group C, GCS score was lower than that of group C, the differences were statistically significant (P<0.05). Before treatment, there was no statistical significant difference in renal function among the four groups (P>0.05). After treatment, the levels of blood urea nitrogen (BUN) and creatinine (Cr) in four groups were lower than those before treatment, and the differences were statistically significant (P<0.05). After treatment, the levels of BUN and Cr in group B were lower than those in group A, and the differences were statistically significant (P<0.05). After treatment, the levels of BUN and Cr in group D were lower than those in group C, and the differences were statistically significant (P<0.05). After treatment, the BUN and Cr of group B were higher than those of group D, and the BUN and Cr of group A were higher than those of group C, the differences were statistically significant (P<0.05). Conclusion Jinshuibao Capsules can enhance the curative effect of severe stroke complicated with hypernatremia and hyperchloremia, accelerate the recovery of neurological function of patients, reduce the damage of renal function, and facilitate the early recovery of patients.
		2021 Vol. 28 (34): 61-64转68 [Abstract] ( 51 ) HTML (38 KB) PDF (0 KB) ( 7 )

	65	Effect of Shugan Jieyu Capsule combined with Aripiprazole on the levels of serum T-SOD, GSH-Px and CAT in patients with schizophrenia
		LU Wei-yu; GAO Yun ;HUANG Jia-yao; CUI Wen-yan; KUANG Ye ;ZHONG Yu-long
		Objective To investigate the effect of Shugan Jieyu Capsule combined with Aripiprazole on the levels of serum total superoxide dismutase(T-SOD),glutathione peroxidase(GSH Px)and catalase(CAT)in patients with schizophrenia (SP). Methods From January 2020 to January 2021, a total of 80 cases of SP patients admitted to Guangzhou Civil Affairs Bureau Mental Hospital were selected as the research objects. According to the random number table method,they were divided into a control group (40 cases) and an observation group (40 cases). Results There was no statistically significant difference in oxidative stress response between the two groups before treatment (P>0.05); after treatment, the T-SOD and GSH-Px of the two groups were higher than those before treatment, and CAT was lower than that before treatment, the differences were statistically significant (P＜0.05); T-SOD and GSH-Px of the observation group were higher than those of the control group after treatment, and CAT of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05).There was no statistically significant difference in the scores of psychiatric symptoms between the two groups before treatment (P>0.05). The symptom scores and total scores of the two groups after treatment were lower than those of the group before treatment, and the observation group was lower than the control group, the differences were statistically significant (P＜0.05). The TESS score of the observation group after treatment was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Shugan Jieyu Capsule combined with Aripiprazole can improve the therapeutic effect of SP, reduce brain oxidative stress, accelerate the improvement of mental symptoms, and is safe and reliable.
		2021 Vol. 28 (34): 65-68 [Abstract] ( 41 ) HTML (34 KB) PDF (0 KB) ( 6 )

	69	Application of general practice team management in patients with mild to moderate Alzheimer′s disease
		ZHANG Yuan-ya; ZHENG Wen;LIAO Ling;YANG Shui-feng;WU Cheng-hui;TAO Ming-hua;HUANG Chen
		Objective To explore the effect of general practice team management in patients with mild to moderate Alzheimer′s disease (AD). Methods A total of 96 patients with mild to moderate AD who were followed up by Shangrao People′s Hospital and Beimen Street Community Health Service Center, Xinzhou District, Shangrao City from January 2016 to December 2019 were selected as the research objects, and were divided into experimental group and the control group according to the random number table method, each with 48 cases. The experimental group was managed by a general practice team, and the control group was managed by routine self-management. Analyze the dopezil hydrochloride and memantine hydrochloride medication rates, mini-mental state examination (MMSE) scores, activities of daily living (ADL) scores, hospital admission rates, and family caregivers′ Zarit burden questionnaire (ZBI) between the two groups of patients score. Results After 1 year of follow-up, the rate of medication in the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). After intervention, the MMSE score and ADL score of the experimental group were higher than those of the control group, and the hospital admission rate and ZBI score were lower than the control group, the differences were statistically significant (P＜0.05).Conclusion General practice team management for patients with mild to moderate AD can improve treatment compliance, better disease control, and reduce the burden on family caregivers with better results.
		2021 Vol. 28 (34): 69-72 [Abstract] ( 38 ) HTML (35 KB) PDF (0 KB) ( 7 )

	73	Prognostic value of SWI scan in patients with acute cerebral infarction with different degrees of cerebral microhemorrhage
		WU Dong-yun; RUAN Feng-hua ;BAI Xue-bing ;YANG Fen
		Objective To investigate the prognostic value of magnetic sensitivity weighted imaging (SWI) in patients with acute cerebral infarction with different degrees of microhemorrhage. Methods A total of 110 patients with acute cerebral infarction admitted to the First Affiliated Hospital of Jiangxi Medical College from January 2019 to February 2020 were selected as the research subjects.They were divided into study group(60 cases,cerebral microhemorrhage)and control group (50 cases, simple acute cerebral infarction) according to the presence or not of cerebral microhemorrhage.According to the number of microbleeds in the study group, the patients were divided into mild group (18 cases, 1-5 microbleeds), moderate group (28 cases, 6-14 microbleeds) and severe group (14 cases, ≥15 microbleeds). Intravenous thrombolytic therapy was carried out reasonably in all patients. The hemorrhagic transformation was observed by SWI scan. The national institutes of health stroke scale (NIHSS) scores and the modified rankin scale (MRS) scores were compared in the four groups. Results There was no significant difference in NIHSS scores among 4 groups before treatment (P>0.05). NIHSS scores at 1 and 14 days after treatment in the four groups were lower than those before treatment, and the differences were statistically significant (P<0.05). There was no significant difference in the proportion of the mRS score among the four groups (P<0.05). There was statistically significant difference in the hemorrhagic transfromation in the four groups (P<0.05). Conclusion Patients with acute cerebral infarction accompanied by moderate to severe cerebral microhemorrhage will significantly increase the incidence of hemorrhagic transformation,which will seriously affect the prognosis of patients. The effective application of SWI scanning method can clarify the situation of cerebral microhemorrhage in patients, and provide a strong basis for clinical thrombolytic therapy.
		2021 Vol. 28 (34): 73-75转86 [Abstract] ( 49 ) HTML (29 KB) PDF (0 KB) ( 8 )

	76	Effect of bionic electrical stimulation combined with music therapy on cognitive function of stroke patients
		CAO Fang; ZHU Dong-yan; QIAN Jun ;WANG Liang ;ZHAI Jia-jia ;HUANG Zhi-dong▲
		Objective To investigate the effect of bionic electrical stimulation combined with music therapy on cognitive function of stroke patients. Methods From December 2019 to October 2020, 52 patients with post-stroke cognitive dysfunction admitted to the Rehabilitation Medicine Center of the First People′s Hospital of Nantong City, Jiangsu Province were selected as the research objects. They were divided into the experimental group and the control group according to random lottery method, with 26 cases in each group. The control group received conventional drug treatment and rehabilitation training, and the experimental group added bionic electrical stimulation and music therapy. The occurrence of adverse reactions was observed during treatment. Before treatment and after 4 weeks of treatment, the two groups of patients were evaluated with mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA)and the modified Barthel index (MBI) to assess the cognitive function and self-care ability in daily life. Results Before treatment, there were no statistically significant differences in MMSE, MoCA and MBI scores between the two groups(P>0.05). After 4 weeks of treatment, MMSE ([25.62±2.33]points), MoCA ([25.04±2.47]points), MBI ([72.12±8.27]points)in experimental group were higher than those in control group ([23.15±3.50], [22.65±3.26], [65.19±8.66]points), and the differences were statistically significant (P<0.05). There were no obvious adverse reactions in the two groups during treatment. Conclusion Bionic electrical stimulation combined with music therapy can promote the improvement of the cognitive function of stroke patients and improve the ability of self-care in daily life.
		2021 Vol. 28 (34): 76-78 [Abstract] ( 41 ) HTML (32 KB) PDF (0 KB) ( 7 )

	79	Application of peripheral blood mononuclear cell PD-L2 molecule in systemic lupus erythematosus
		LIU Yu-wen ;LIU Ping ;HU Na; GE Hong-liang; PENG Yu-wei
		Objective To investigate the application of peripheral blood mononuclear cell (PBMC) programmed death ligand-2 (PD-L2) molecule in systemic lupus erythematosus (SLE). Methods The clinical data of 30 patients with SLE admitted to Pingxiang People′s Hospital from January 2019 to January 2020 were retrospectively analyzed. A total of 15 patients with lupus nephritis at active stage with SLE disease activity index (SLEDAI) score >5 points were included into the active group, a total of 15 patients with lupus at remission stage with SLEDAI score ≤5 points were included into the remission group, a total of 10 patients with rheumatoid arthritis (RA) treated in Pingxiang People′s Hospital during the same period were selected as active control cases and included in the RA group, and 10 healthy volunteers who received physical examination were included in the normal control group. All selected candidates received PD-L2 molecular detection of PBMC, the application value of PD-L2 molecule expression level of PBMC in SLE patients was analyzed. Results There was no statistical significant difference in the expression level of PD-L2 molecule in SLE patients with different gender, age and weight (P>0.05); The expression level of PD-L2 molecule of patients in the active group was higher than that in patients of the remission group and the normal control group, and the differences were statistically significant (P<0.05); there was no statistical significant difference in the expression level of PD-L2 molecule of patients between the active group and the RA group (P>0.05); Pearson correlation analysis found that SLEDAI score was positively correlated with PD-L2 molecular expression level of SLE patients (r=0.946, P=0.000); the receiver operating curve was drawn, the results showed that the area under the curve of PD-L2 molecular expression level in the prediction of SLE patients at active stage was 0.820, which had high predictive value. Conclusion The expression level of PD-L2 molecule in PBMC is closely related to the degree of disease activity in SLE patients, which can assist clinical evaluation of the severity of the disease, and provide effective reference for the formulation of clinical treatment regimen.
		2021 Vol. 28 (34): 79-82 [Abstract] ( 44 ) HTML (34 KB) PDF (0 KB) ( 5 )

	83	Clinical effect of early tracheotomy in patients with severe cerebral infarction combined with pulmonary infection
		LIN Kang-yue ;LIAO Xiao-rong ;YE Shi-sheng ;XIAO Yu-mei
		Objective To explore the clinical effect of early tracheotomy in patients with severe cerebral infarction combined with pulmonary infection. Methods The clinical data of 78 patients with early acute severe cerebral infarction complicated with pulmonary infection in the intensive care unit (ICU) of Maoming People′s Hospital from January 2017 to July 2020 was retrospectively analyzed. According to the time of tracheotomy after admission, patients were divided into an early tracheotomy group with 36 cases and a late tracheotomy group with 42 cases. The duration of mechanical ventilation, stay in ICU, total hospital stay, duration of antibiotic use, combined antibiotic use rate, complication rate, ICU mortality rate, and total hospital fatality rate were compared between the two groups. Results There was no significant difference in the total complication rate of tracheotomy, ICU mortality rate, or total hospital fatality rate between the two groups (P>0.05). The duration of mechanical ventilation, stay in ICU, total hospital stay, duration of antibiotic use, combined antibiotic use rate and total incidence of serious complications in the early tracheotomy group were lower than those in the late tracheostomy group, and the differences were statistically significant (P<0.05). Conclusion Early tracheotomy is beneficial to decrease the total incidence of serious complications and the use of combined antibiotics in patients with early severe cerebral infarction combined with pulmonary infection, and shorten mechanical ventilation, and reduce antibiotic use,stay in ICU,and total hospital stay. It is worthy of promotion and application in clinical practice.
		2021 Vol. 28 (34): 83-86 [Abstract] ( 44 ) HTML (34 KB) PDF (0 KB) ( 8 )

	87	Clinical effect of Olanzapine combined with Paroxetine Hydrochloride in the treatment of depression
		PENG Fu-zhi;CHEN Jin-hong▲
		Objective To investigate the clinical effect of Olanzapine combined with Paroxetine Hydrochloride in the treatment of depression. Methods A total of 88 patients with depression admitted to Hu′nan Brain Hospital from January to October 2020 were selected as the research objects and divided into the control group and the study group according to the random number table method, with 44 cases in each group. The control group was treated with Paroxetine Hydrochloride, and the study group was treated with Olanzapine combined with Paroxetine Hydrochloride. The total effective rate, Hamilton depression scale (HAMD) and quality of life scores were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). After intervention, the HAMD score of the study group was lower than that of the control group, and the difference was statistically significant (P<0.05). After intervention, the quality of life score of patients in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of patients with depression, the effect of Olanzapine combined with Paroxetine Hydrochloride treatment is better, which can effectively relieve the symptoms of patients, effectively improve the negative emotions of patients and improve their quality of life. It has certain advantages and is suitable for widespread promotion.
		2021 Vol. 28 (34): 87-89 [Abstract] ( 48 ) HTML (30 KB) PDF (0 KB) ( 4 )

	90	The effects of game-based rehabilitation intervention on the fine motor function and compliance of children with cerebral palsy
		LI Jin ;YIN Bing-bing ;YANG Ying ;LI Run-jie
		Objective To explore the effects of game-based rehabilitation intervention on the fine motor function and compliance of children with cerebral palsy. Methods A total of 60 children with cerebral palsy admitted to Dalian Women and Children′s Medical Center (Group) from March 2018 to May 2020 were selected and divided into a control group with 30 cases and an observation group with 30 cases according to the random number table. The children in the control group received routine rehabilitation training, and the children in the observation group combined with game based rehabilitation intervention on the basis of the control group. Both groups continued to intervene for 6 months. The scores of activity of daily living scale (ADL), gross motor function measure (GMFM), fine motor function measure(FMFM) and rehabilitation training compliance of disabled children before and after intervention were compared between the two groups. Results Compared with the pre-intervention period, the scores of ADL, GMFM, fine motor ability values, visual tracking ability, upper limb joint movement mobility, grasping ability, operational ability, hand-eye coordination ability, participation in family rehabilitation training, participation in trial sessions, motor function exercise,fun activities, and overall training compliance scores in both groups all increased after the intervention, and the above indexes in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion The application of game based rehabilitation intervention in children with paralysis can effectively promote the recovery of self-care ability, improve gross motor and fine motor function, and improve the compliance of rehabilitation training.
		2021 Vol. 28 (34): 90-93 [Abstract] ( 42 ) HTML (36 KB) PDF (0 KB) ( 7 )

	94	Prognostic value of TNFR1 and TNFR2 in predicting of patients with maintenance hemodialysis
		ZHONG Xiao-rong; YANG Feng
		Objective To investigate the value of tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2) in predicting the risk of all-cause death and cardiovascular death in maintenance hemodialysis(MHD) patients. Methods A total of 300 MHD patients in the Blood Purification Center of Fuzhou First Hospital from March 1 to April 1, 2019 were prospectively followed up for 2 years. According to the endpoint survival and death, they were diveded into the survival group (245 cases) and the death group (55 cases). The baseline data were collected.TNFR1 and TNFR2 were measured by double antibody sandwich ABC-ELISA. The end points events were all-cause death and cardiovascular deaths. Cox regression analysis was used to analyze the independent risk factors of all-cause mortality and cardiovascular mortality. Receiver operating characteristic (ROC) curve and Youden index were used to evaluate the predictive value of TNFR1 and TNFR2 on all-cause death and cardiovascular death in MHD patients.Results The age of the death group was older than that of the survival group, the dialysis time of the death group was longer than that of the survival group, the levels of systolic blood pressure, TNFR1 and TNFR2 of the death group were higher than those of the survival group, and the level of albumin of the death group was lower than that of the survival group, the differences were statistically significant (P＜0.05). Among the 300 MHD patients, 55 cases (18.33%) died,included 20 (36.36%) from cardiovascular disease. Multivariate Cox regression analysis showed that TNFR1 (β=0.018,OR=1.018, 95%CI=11.015-1.021), TNFR2 (β=0.007, OR=1.007, 95%CI=1.005-1.009) were independent risk factors for all-cause death in MHD patients (P＜0.01); TNFR1 (β=0.016, OR=1.016, 95%CI=1.011-1.021), TNFR2 (β=0.007,OR=1.007, 95%CI=1.004-1.011) were independent risk factors for cardiovascular death in MHD patients (P＜0.01). The AUC of TNFR1 and TNFR2 predicting all-cause death in MHD patients were 0.970 and 0.938, respectively, and the AUC predicting cardiovascular death were 0.905 and 0.881, respectively. Conclusion The elevated concentrations of TNFR1 and TNFR2 are closely related to the prognosis of MHD patients, and which are of great value in judging the prognosis of MHD patients
		2021 Vol. 28 (34): 94-97 [Abstract] ( 39 ) HTML (36 KB) PDF (0 KB) ( 6 )

	98	Influence of precision-precise dissection of urethral mucosa at prostatic apex during transurethral enucleation of prostate on postoperative urinary control in patients
		ZENG Xian-you; LI Qiu-shui; XIAO Wen-xing▲
		Objective To observe the influence of precision-precise dissection of urethral mucosa at prostatic apex during transurethral enucleation on postoperative urinary control in patients. Methods A total of 80 cases of benign prostate hyperplasia in Affiliated Hospital of Jinggangshan University were selected and randomly divided into the experimental group (40 cases) and the control group (40 cases) according to random number table method. In the control group, the urethral mucosa in the apex of the prostate was concentrated to 12 o′clock and then dissected after anatomic enucleation of the prostate. In the experimental group, the urethral mucosa at the apex of the prostate was accurately dissected before enucleation, and then the prostate was anatomically enucleated. The incidence of postoperative urinary incontinence, recovery time of urinary control, perioperative period indexes such as total operative time, time of gland dissection, intraoperative blood loss, bladder irrigation time, catheter indwelling time, postoperative hospitalization time and follow-up results were compared between the two groups. Results The incidence of urinary incontinence in the experimental group was lower than that in the control group, the difference was statistically significant (P<0.05). The recovery time of urinary control in the experimental group was shorter than that in the control group, the difference was statistically significant (P<0.05). There were no significant differences in the indexes of perioperative period indexes such as the total operative time, dissection time, intraoperative blood loss, bladder irrigation time, catheter indwelling time, postoperative hospitalization time and postoperative follow-up efficacy of International Prostate Symptom Scale(IPSS), the score of quality of life (QOL), Qmax, postvoid residual (PVR) between the two groups (P>0.05). Conclusion Precise separation of the urethral membrane of the apex of the prostate during transurethral enucleation of the prostate can reduce the incidence of urinary incontinence and shorten the recovery time of urinary control.
		2021 Vol. 28 (34): 98-101 [Abstract] ( 32 ) HTML (37 KB) PDF (0 KB) ( 7 )

	102	Clinical effect of colon perfusion dialysis machine with Niaoduqing retention enema in the treatment of chronic renal failure
		CHENG Hao ;CHENG Fang-xi; LIU Yan
		Objective To explore the clinical effect of colon perfusion dialysis machine with Niaoduqing retention enema in the treatment of chronic renal failure (CRF). Methods A total of 120 cases of CRF patients who were admitted to the Second People′s Hospital of Jingdezhen City from January 2020 to December 2020 were selected as the research subjects, and they were divided into the control group (60 cases) and the observation group (60 cases) using a random number table method. Patients in the control group were treated with an artificial Niaoduqing retention enema, and patients in the observation group were treated with a colon perfusion dialysis machine with Niaoduqing retention enema.Both groups were treated for 2 weeks. The clinical efficacy after treatment, and the improvement of clinical symptoms and changes of renal function indexes before and after treatment were compared between the two groups. Results The total clinical effective rate of the observation group after treatment was 96.67%, which was higher than that of the control group (83.33%),the difference was statistically significant (P＜0.05).The scores of facial limb edema,fatigue,limb sleepiness, false stool and the levels of serum creatinine (SCr) and blood urea nitrogen (BUN) in the two groups after treatment were lower than those before treatment,the differences were statistically significant (P＜0.05).The scores of facial limb edema, fatigue, limb sleepiness, false stool and the levels of SCr and BUN in the observation group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Colon perfusion dialysis machine with retention enema treatment can more effectively improve the clinical symptoms of patients with CRF, ameliorate treatment effect, improve the patient′s renal function, and delay the deterioration of the disease.
		2021 Vol. 28 (34): 102-104转108 [Abstract] ( 40 ) HTML (32 KB) PDF (0 KB) ( 9 )

	105	Clinical effect of Bupi Yishen Decoction in the treatment of patients with maintenance hemod -ialysis complicated with malnutrition and the influence on patients′ physical and mental health
		WU Fu-xian;JIANG Hui
		Objective To explore the clinical effect of Bupi Yishen Decoction in the treatment of patients with maintenance hemodialysis complicated with malnutrition and the influence on patients′ physical and mental health. Methods A total of 60 patients with maintenance hemodialysis complicated with malnutrition in Pizhou Hospital of Traditional Chinese Medicine from January to December 2019 were selected as the research subjects. According to random number table method, they were divided into the treatment group and the control group, 30 cases in each group. The control group was treated with clinical routine treatment, on this basis, the treatment group was treated with Bupi Yishen decoction.The clinical efficacy of the two groups was observed, and the improvement of patient generated subjective global assessment (PG-SGA) score, self-rating anxiety scale (SAS) score and the clinical symptom score were compared before and after treatment of the two groups. Results After 3 months of treatment, the total clinical effective rate of the treatment group was 83.33% (25/30), which was higher than that of the control group 63.33% (19/30), the difference was statistically significant (P＜0.05). After 3 months of treatment, the PG-SGA score, the SAS score and the clinical symptom score of the treatment group were lower than those of the control group and before treatment, the differences were statistically significant (P ＜0.05). Conclusion For patients with maintenance hemodialysis complicated with malnutrition, the combination of Bupi Yishen Decoction has a better curative effect, which can effectively improve the malnutrition status and clinical symptoms of patients, and relieve their psychological anxiety. This method has a high clinical value, so it is suggested to promote it.
		2021 Vol. 28 (34): 105-108 [Abstract] ( 33 ) HTML (35 KB) PDF (0 KB) ( 7 )

	109	Clinical effect of microchannel percutaneous nephrolithotomy in the treatment of patients with kidney stones and its influence on inflammatory factors
		HUANG Bao-qing
		Objective To explore the clinical effect of microchannel percutaneous nephrolithotomy in the treatment of patients with kidney stones and its influence on inflammatory factors. Methods A total of 140 patients with kidney stones who were treated with microchannel percutaneous nephrolithotomy and admitted to the Department of Urology,Hunan Aerospace Hospital from September 2017 to September 2019 were selected as the research subjects, and the patients were divided into a control group (n=70) and an observation group (n=70) by computer random drawing method.Patients in the observation group were treated with microchannel percutaneous nephrolithotomy, and patients in the control group were treated with standard-channel percutaneous nephrolithotomy. The clinical indexes, levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and the total incidence of complications were compared between the patients of two groups. Results The operation time of the observation group was longer than that in the control group, the intraoperative blood loss was less than that in the control group, and the bed time and hospital stay were shorter than that in the control group, the differences were statistically significant (P<0.05). Before treatment, the IL-6 and TNF-α levels of patients in the two groups were compared, and the differences were not statistically significant (P>0.05). After treatment, the levels of IL-6 and TNF-α in the two groups were higher than those before treatment, and the levels of IL-6 and TNF-α in the observation group were lower than those in the control group, with statistical significances (P<0.05). During the treatment, the total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion For patients with kidney stones, the use of microchannel percutaneous nephrolithotomy can obtain better effects than traditional standard channel operation. It can effectively shorten the operation time, reduce the surgical trauma of the patient and accelerate the recovery of the patient. Meanwhile, the reduction of surgical wounds can alleviate the inflammatory stress response of patients, and also reduce the probability of postoperative complications in patients, which has the value of promotion and application.
		2021 Vol. 28 (34): 109-112 [Abstract] ( 47 ) HTML (35 KB) PDF (0 KB) ( 6 )

	113	Application of blood glucose management team and hospital-level blood glucose management system in orthopedic perioperative period
		ZHU Ming-hui ;ZHANG Ya-wei▲
		Objective To explore the application of blood glucose management team and hospital-level blood glucose management system in the perioperative period of orthopedics. Methods A total of 68 patients with fracture or joint replacement undergoing elective surgery for diabetes mellitus were selected in Department of Endocrinology, Pingxiang People′s Hospital from June 2017 to June 2020. Thirty-four patients treated before the establishment of blood glucose management team (June 2017 to December 2018) were set as the control group, thirty-four patients treated after the establishment of blood glucose management team (January 2019 to June 2020) were set as the observation group. Patients in the control group received routine blood glucose detection, and patients in the observation group received combined blood glucose detection by blood glucose management team and hospital-level blood glucose management system. Patients in both groups were followed up for 3 months after discharge. The acceptance of health education on blood glucose management knowledge, the passing of blood glucose management knowledge questionnaire, the incidence of hypoglycemia and nursing satisfaction were compared between the two groups. Results The acceptance rate of health education on blood glucose management knowledge, the passing rate of blood glucose management knowledge questionnaire and nursing satisfaction in the observation group were higher than those in the control group; the incidence of hypoglycemia in the observation group was lower than that in the control group, the differences were statistically significant(P<0.05). Conclusion The blood glucose management team and the hospital level blood glucose management system can effectively reduce the incidence of hypoglycemia in patients with fracture or joint replacement undergoing elective surgery for diabetes mellitus, and increase their acceptance and understanding of diabetes related knowledge, and improve their satisfaction with nursing.
		2021 Vol. 28 (34): 113-115 [Abstract] ( 34 ) HTML (29 KB) PDF (0 KB) ( 7 )

	116	Efficacy of Compound α-ketoacid Tablets on renal function and serum indexes in patients with diabetic nephropathy
		YOU Ping-ping ;KE Yuan-yuan; XU Jia-qi; DAI Lian▲
		Objective To explore the efficacy of Compound α-ketoacid Tablets on renal function and serum indexes in patients with diabetic nephropathy. Methods A total of 130 patients with diabetic nephropathy in the Third People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2018 to December 2020 were selected as subjects and divided into the test group and the control group according to random number table method,65 cases in each group. The control group received conventional treatment, and the test group was based on the control group, taking Compound α-ketoacid Tablets. Both groups were given treatment for 3 consecutive months. The changes of renal function index, renal interstitial fibrosis index and oxidative stress response index were compared between the two groups before and after treatment. Results After treatment, serum urea nitrogen (BUN), blood creatinine (Cr), homocysteine (Hcy), vascular endothelial growth factor (VEGF) and malondialdehyde (MDA) levels in the test group were lower than those in the control group, the differences were statistically significant (P<0.05). Serum levels of hepatocyte growth factor (HGF), total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in the test group after treatment were higher than those in the control group, the differences were statistically significant (P<0.05). After treatment,the glomerular filtration rate (GFR) of the test group was faster than that of the control group, the difference was statistically significant (P<0.05). Conclusion Compound α-ketoacid Tablets can protect the renal function of patients with diabetic nephropathy, inhibit the occurrence of oxidative stress, and improve the indicators of renal interstitial fibrosis,and promote the improvement of the condition.
		2021 Vol. 28 (34): 116-119 [Abstract] ( 45 ) HTML (34 KB) PDF (0 KB) ( 9 )

	120	Effect of Berberine on gastrointestinal hormones and glucose and lipid metabolism in patients with early type 2 diabetes mellitus
		CHEN Zhi-xiong;WANG Chen-xiu;XU Lian-qiang;LIU Yao-yao
		Objective To explore the effect of Berberine on gastrointestinal hormones and glucose and lipid metabolism in patients with early type 2 diabetes mellitus (T2DM). Methods Sixty patients with early T2DM who were treated in the Department of Endocrinology, Jiangxi Provincial People′s Hospital from January to December 2019 were selected as the research subjects, and all received conventional treatment. They were divided into control group and experimental group by random number table method, with 30 cases in each group. The control group was treated with Gliclazide, and the test group was added with Berberine orally. The changes in gastrointestinal hormones and glucose and lipid metabolism were compared between the two groups after 8 weeks of continuous treatment. Results There were no statistical differences in the level of fasting Ghrelin, glucagon-like peptide-1 (GLP-1), fasting C peptide, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c) and total cholesterol (TC), and triacylglycerol (TG) before treatment(P>0.05). The fasting Ghrelin, GLP-1 and fasting C-peptide after 8 weeks of medication were higher than those before treatment, and the differences were statistically significant (P<0.05). The fasting Ghrelin, GLP-1, and fasting C-peptide in the test group were higher than those in the control group after 8 weeks of medication, and the differences were statistically significant (P<0.05). The levels of FBG and HbA1c in the two groups after 8 weeks of medication were lower than those before treatment, with statistical significances (P<0.05). The levels of FBG and HbA1c in the test group were lower than those in the control group after 8 weeks of medication, and the differences were statistically significant (P<0.05). The levels of TC and TG after 8 weeks of medication were lower than those before treatment in the two groups,and the differences were statistically significant (P<0.05). After 8 weeks of treatment, the levels of TC and TG in the test group were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion The use of Berberine in patients with early stage T2DM can help increase the level of gastrointestinal hormones, improve intestinal function, and promote glucose and lipid metabolism.
		2021 Vol. 28 (34): 120-122转126 [Abstract] ( 44 ) HTML (34 KB) PDF (0 KB) ( 7 )

	123	The effect of Insulin Glargine combined with Glimepiride in the treatment of senile diabetes
		ZHANG Jian ;XIE Bing-song ;LIN Dan-na ;YI Qing-qing ;ZHANG Yue-yang
		Objective To explore the effect of Insulin Glargine combined with Glimepiride in the treatment of senile diabetes. Methods The clinical data of 300 elderly diabetic patients admitted to Longhua Community Health Center from May 2018 to May 2019 were collected retrospectively, and grouped according to the treatment method. The control group (n=150) was treated with Insulin Glargine and observation group (n=150) was given Glimepiride treatment on this basis, and the total effective rate, blood glucose level, renal function index, total incidence of adverse reactions of the two groups were compared. Results The total effective rate of the patients in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). The fasting blood glucose, two hours postprandial blood glucose and glycosylated hemoglobin in the observation group after 3 months of treatment were lower than those in the control group (P<0.05). The levels of serum creatinine (Scr) and blood urea nitrogen (BUN) after treatment were lower than those before treatment (P<0.05). There was no significant difference in Scr level and BUN level between the two groups before and after treatment (P>0.05). There was no significant adverse reaction in the two groups.Conclusion In the clinical treatment of elderly diabetic patients, the combined use of Insulin Glargine and Glimepiride has a positive effect, promotes the control of blood sugar levels, and further promotes the improvement of renal function,which is worthy of promotion.
		2021 Vol. 28 (34): 123-126 [Abstract] ( 44 ) HTML (34 KB) PDF (0 KB) ( 7 )

	127	Correlation analysis between gestational diabetes mellitus and hypothyroidism
		HUANG Jian-chun
		Objective To explore the relationship between hypothyroidism and gestational diabetes mellitus (GDM), to analyze and understand the possible influence of thyroid hormone (TH) on blood glucose levels during pregnancy, and to analyze whether blood glucose will advance hypothyroidism. Methods A total of 664 pregnant women who underwent routine obstetrics at the No. 4 People′s Hospital of Zhanjiang from November 2019 to November 2020 were selected as the research subjects. According to the results of oral glucose tolerance test (OGTT) and thyroid function, 232 patients with GDM and hypothyroidism were selected as group A, 224 pregnant women with simple GDM were selected as group B, and 208 pregnant women with simple hypothyroidism were selected as group C. All pregnant women were tested for related thyroid function: free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-thyroglobulin antibody (TGAb) positive rate and anti-thyroid peroxidase autoantibody (TPOAb) positive rate. Blood glucose indicators such as fasting blood glucose (FPG) and glycosylated hemoglobin (HbA1c), OGTT 1 h, and OGTT 2 h were measured. Blood lipid indicators including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and total cholesterol (TC) were determined. The levels and differences of related thyroid and blood lipid indicators between group A and C were observed and compared. The levels and differences of related thyroid and blood lipid indicators between group A and B were observed and compared. The correlation between related thyroid function indicators and blood glucose indicators in group C and correlation between related thyroid function indicators and blood glucose indicators in group A were explored. Results The levels of FT4, FT3, and HDL in group A were lower than those in group Cwith statistical significance (P<0.05). The TG level in group A was higher than that in group C, and the difference was statistically significant (P<0.05). The HbA1c, TSH, TC, and LDL levels and TPOAb and TGAb positive rates of group A were higher than those of group B with statistical significance(P<0.05). Correlation analysis indicated that there was a negative correlation between OGTT 2 h blood glucose level and FT4 in group C, and the difference was statistically significant (P<0.05). There was a positive correlation between TSH and FBG in group A, and the difference was statistically significant (P<0.05). Conclusion During pregnancy, hypothyroidism will significantly increase the pregnant women′s FBG, OGTT 1 h, and OGTT 2 h levels, and also induce abnormal lipid metabolism. GDM will further aggravate the abnormal thyroid function of pregnant women, and the two will interact with each other.
		2021 Vol. 28 (34): 127-130 [Abstract] ( 49 ) HTML (37 KB) PDF (0 KB) ( 7 )

	131	Clinical effect of Liraglutide combined with Metformin in the treatment of type 2 diabetes mellitus
		WANG Ming-wei
		Objective To investigate the clinical effect of Liraglutide combined with Metformin in the treatment of type 2 diabetes mellitus. Methods A total of 80 patients with type 2 diabetes admitted to Beijing Changping District Hospital from January 2020 to January 2021 were selected as research objects, according to random number table method,they were divided into control group (40 cases) and study group (40 cases), the control group was treated with Metformin combined with Glimepiride, and the study group was treated with Metformin combined with Liraglutide. Therapeutic effect, blood glucose, islets β-cell function, blood lipid, body mass index (BMI), and adverse reactions were compared between the two groups. Results The efficacy of study group was higher than that of control group, and the difference was statistically significant (P<0.05). The levels of HbA1c, fasting blood glucose and 2 h postprandial blood glucose in the study group after treatment were lower than those in the control group, with statistical significance (P<0.05). After treatment, fasting insulin, β cell secretion index of the homeostasis model and islet resistance index of the homeostasis model in the study group were lower than those in the control group, and the differences were statistically significant (P<0.05). The indexes of total cholesterol, triglyceride and low density lipoprotein cholesterol in the study group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05). After treatment, the BMI of the study group was lower than that of the control group, and the difference was statistically significant (P<0.05). There was no statistical significance in the total incidence of adverse reactions between two groups (P>0.05). Conclusion The implementation of Liraglutide combined with Metformin therapy can significantly improve the treatment effect of type 2 diabetes mellitus, which is beneficial to effectively reduce blood glucose, BMI,improve lipid profile and pancreatic islet function in patients with high safety, without obvious side effects, and is worthy of promotion.
		2021 Vol. 28 (34): 131-134 [Abstract] ( 45 ) HTML (38 KB) PDF (0 KB) ( 8 )

	135	Clinical study on the effect of Dexmedetomidine on cognitive dysfunction after general anesthesia in elderly patients with colon cancer
		CHEN Yang ;LIANG Yong-sheng ;TANG Bo
		Objective To explore the effect of Dexmedetomidine on cognitive dysfunction (POCD) in elderly patients with colon cancer after general anesthesia. Methods Forty elderly patients with colon cancer without metastasis who needed operation in Yangjiang Hospital of Traditional Chinese Medicine from August 2020 to April 2021 were selected as the research objects, and were divided into reference group and application group according to the random envelope method, with 20 cases in each group. In the application group, 0.7 μg/kg Dexmedetomidine was pumped intravenously within 10 min after induction of tracheal intubation under general anesthesia, while in the reference group, Dexmedetomidine was not used intraoperatively. Mini-mental state examination (MMSE) score, incidence of POCD, S100-β protein and interleukin-6 (IL-6) levels were compared between the two groups 1 d before surgery and 1 d and 2 d after surgery. Results There was no significant difference in MMSE score 1 day before operation between the two groups (P>0.05). The MMSE score of the application group was higher than that of the reference group 1 and 2 days after operation, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of POCD between the two groups (P>0.05). There were no significant differences in S100-β and IL-6 levels between the two groups 1 day before surgery (P>0.05). The levels of S100-β and IL-6 in the application group were lower than those in the reference group on day 1 and 2 after operation, with statistical significance (P<0.05). Conclusion The application of Dexmedetomidine during general anesthesia in elderly patients with colon cancer has little effect on postoperative cognitive function, and has a certain protective effect on the patient′s nervous system.
		2021 Vol. 28 (34): 135-138 [Abstract] ( 43 ) HTML (34 KB) PDF (0 KB) ( 6 )

	139	Effect of Dexmedetomidine on inflammatory cytokines and coagulation function of the patients undergoing microvascular decompression surgery
		WANG Rong-guo;DING Wen-ping;LIU Qian;MAN Yuan-yuan▲
		Objective To investigate the effects of Dexmedetomidine (DEX) on serum inflammatory factors and coagulation function in perioperative patients undergoing trigeminal nerve microvascular decompression. Methods A total of 60 patients with trigeminal nerve microvascular decompression admitted to Xuzhou Central Hospital from January 2017 to October 2020 were selected as the study subjects,and were divided into DEX group(30 cases)and control group(30 cases)by random number table method. DEX group was given DEX load dose of 1 μg/kg, maintenance dose of 0.5 μg/ (kg·h),and control group was given normal saline at the same time. Operation time and anesthesia time were compared between the two groups, and changes of heart rate (HR) and mean arterial pressure (MAP), tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) levels and prothrombin time (PT), activated partial thrombin time (APTT) were observed before drug administration (T0), after intubation (T1), 10 min before surgery (T2), and 1 h after surgery (T3). Results There was no significant difference in operation time and anesthesia time between the two groups (P>0.05). There were no significant differences in MAP, HR, TNF-α and IL-6 levels between the two groups at T0 (P>0.05). MAP, HR, TNF-α and IL-6 levels at T1, T2 and T3 in DEX group were lower than those in control group, the differences were statistically significant (P<0.05). There were no significant differences in PT and APTT levels between the two groups at T0, T1, T2 and T3(P>0.05). Conclusion DEX has a significant anesthetic effect in trigeminal microvascular decompression, and can effectively reduced the stress response of the body. However, there is no obvious evidence to link the coagulation function enhancement of DEX with its inhibitory effects on inflammatory responses, which might be just associated with its attenuation effects on hemodynamics of patients.
		2021 Vol. 28 (34): 139-142转146 [Abstract] ( 43 ) HTML (43 KB) PDF (0 KB) ( 7 )

	143	Effect of ultrasound guided subcutaneous transversal muscle and fascia block combined with general anesthesia on analgesic effect and stress response of patients undergoing laparoscopic surgery
		XU Xiao-mei;WANG Deng-ji▲
		Objective To study the effect of ultrasound-guided transverse fascia block on postoperative analgesia in patients undergoing laparoscopic surgery. Methods A total of 86 patients undergoing laparoscopic surgery in the Affiliated Hospital of Xuzhou Medical University from June 2018 to January 2021 were selected as the research objects, and were divided into experimental group (43 cases) and control group (43 cases) according to the random number table method. The control group received general anesthesia for surgery, and the experimental group underwent ultrasoundguided transverse abdominal fascia plane block combined with general anesthesia for surgery, the analgesic effect and stress response of the two groups were compared. Results The visual analog scale (VAS) score of the experimental group was lower than that of the control group at 6, 12 and 24 h after surgery, and the difference was statistically significant (P<0.05). The levels of cortisol (Cor), adrenocorticotropin (ACTH) and adrenalin (A) in the two groups after operation were higher than those before operation, while the levels of glutathione peroxidase (GSH-Px) were lower than those before operation, the differences were statistically significant (P<0.05). Cor, ACTH and A levels in the experimental group were lower than those in the control group, while GSH-Px levels were higher than those in the control group, with statistical significance (P<0.05). Conclusion Patients undergoing endoscopic surgery, ultrasound-guided transverse abdominal fascia plane block combined with general anesthesia has better postoperative analgesic effect and significantly reduces postoperative stress response compared with traditional general anesthesia.
		2021 Vol. 28 (34): 143-146 [Abstract] ( 40 ) HTML (34 KB) PDF (0 KB) ( 7 )

	147	Application value of computerized tomography angiography combined with ultrasound in the preoperative diagnosis of congenital vascular malformation of tetralogy of fallot
		ZHANG Zhen-hua ;WU Zhu-qiang; DING Shan
		Objective To explore the application value of computerized tomography (CT) angiography combined with cardiac ultrasound in the preoperative diagnosis of congenital vascular malformation of tetralogy of fallot (TOF). Methods A total of 80 children patients with confirmed TOF in Jiangxi Provincial Children′s Hospital between January 2018 and July 2020 were selected as the research object retrospectively, fcardiac ultrasound and 64 rows of spiral CT angiography, the application of multiple image postprocessing technology for image reconstruction, combined with cardiac ultrasound and clinical surgery results, and the value of CT angiography combined with cardiac ultrasound in the preoperative diagnosis of TOF congenital vascular malformations was evaluated. Results The sensitivity in the diagnosis of CT angiography combined with cardiac ultrasound were higher than that in the separate diagnosis of cardiac ultrasound and CT angiography, with statistical significant differeces (P＜0.05). And the accuracy in the diagnosis of CT angiography combined with cardiac ultrasound were higher than that in the separate diagnosis of cardiac ultrasound, with statistical significant differeces (P＜0.05). The three inspection methods were very consistent (Kappa=0.468, 0.451, 0.628).Conclusion CT angiography combined with cardiac ultrasound can provide accurate and reliable imaging basis for the clinic, reduce unnecessary traumatic examinations, and provide favorable support for the formulation of surgical plans.
		2021 Vol. 28 (34): 147-150 [Abstract] ( 32 ) HTML (34 KB) PDF (0 KB) ( 6 )

	151	Diagnosis of breast cancer by dynamic enhanced MRI dynamic enhancement scan combined with mammography analyze
		LUO Yong; ZHOU Fei-fei ;WU Zhou-yang; WANG Wei-ming; WU Guo-hui
		Objective To analyze the diagnosis of breast cancer by dynamic enhanced MRI scan combined with mammography. Methods A total of 60 patients with suspected breast cancer admitted to the Department of Radiology of Shangrao People′s Hospital from January 2019 to December 2020 were selected as the research objects. All patients received mammography examination, MRI dynamic enhancement scan examination and MRI dynamic enhancement scan combined with mammography examination. The clinicopathological examination results were used as the gold standard,the diagnosis results of the three examination methods in breast cancer lesions, the three examination methods and the detection results and diagnostic efficiency of pathological examinations were compared. Results The pathological examination findings revealed that of the 73 lesions in this study,58 (41 cases)were malignant lesions,all of which were breast cancer,and 15 (19 cases)were benign lesions.MRI dynamic enhanced scanning combined with mammography examination showed that the detection rate of breast cancer was 81.67% (49/60), which was higher than the 36.67% (22/60) of mammography examination and 51.57% (31/60) of MRI dynamic enhanced scanning examination, with statistically significant difference (P<0.05). Mammography examination were positive in 37 cases and negative in 23 cases, of 29 cases were the true positives; MRI dynamic enhanced scanning examination were positive in 39 cases and negative in 21 cases, of 33 cases were the true positives; the MRI dynamic enhanced scanning combined with mammography examination was positive 40 cases, 20 cases were negative, of 39 cases were the true positives. The three inspection methods had high specificity, sensitivity and accuracy for breast cancer. Comparison of accuracy, sensitivity and specificity between MRI dynamic enhanced scanning examination and mammography examination, the differences were not statistically significant (P>0.05). And accuracy, sensitivity and specificity of the MRI dynamic enhanced scanning combined with mammography examination were higher than those of mammography examination and MRI dynamic en-hanced scanning examination, and the differences were statistically significant (P<0.05). Conclusion MRI dynamic enhanced scanning combined with mammography can improve the accuracy, sensitivity and specificity of diagnosis on the basis of ensuring the detection rate of pathological classification of breast cancer. It has high diagnostic value and is beneficial to early and effective treatment of breast cancer patients.
		2021 Vol. 28 (34): 151-153转157 [Abstract] ( 43 ) HTML (32 KB) PDF (0 KB) ( 8 )

	154	Clinical value of CT and MRI in evaluating the residual lesions of primary hepatocellular carcinoma after interventional therapy
		LING Qu-ping;ZHONG Wan; YANG Pei-hua
		Objective To explore the clinical value of CT and MRI in evaluating the residual lesions of primary hepatocellular carcinoma after interventional therapy. Methods The clinical data of 82 patients with primary hepatocellular carcinoma admitted to the Fifth People′s Hospital of Ganzhou City from August 2018 to August 2020 were retrospectively analyzed. The results of digital subtraction angiography (DSA) were taken as the gold standard. The sensitivity,specificity, accuracy and diagnostic efficiency of the two methods were compared. Results The sensitivity, specificity,accuracy and Kappa value of MRI in the diagnosis of residual lesions were 89.71%, 100.00%, 92.86% and 0.929 respectively, which were higher than 69.12%, 100.00%, 78.57% and 0.578 of dynamic contrast-enhanced CT, and the differences were statistically significant （P＜0.05）. Conclusion For the clinical diagnosis of residual lesions of primary hepatocellular carcinoma after interventional therapy, MRI has a more accurate result than CT dynamic enhancement,and it can examine the recurrent lesions earlier, and is of great significance to the formulation of subsequent treatment plans.
		2021 Vol. 28 (34): 154-157 [Abstract] ( 27 ) HTML (34 KB) PDF (0 KB) ( 5 )

	158	The value of magnetic resonance imaging in assessing the degree of joint damage in patients with knee degenerative osteoarthritis
		LIU Yan-ping ;LIAO Zhong-jian ;LI Zheng-nan▲
		Objective To explore the evaluation value of magnetic resonance imaging (MRI) in patients with knee degenerative osteoarthritis for the degree of joint damage. Methods Retrospective analysis of the clinical data of 130 patients with knee degenerative osteoarthritis admitted to Ganzhou People′s Hospital from July 2019 to July 2020. All of the patients were examined by MRI, and used the arthroscopic results as the gold standard, observed the diagnostic value of the MRI, and the detection rate of arthritis symptoms and the classification of articular cartilage injury were compared. Results The sensitivity of MRI to the diagnosis of articular cartilage injury was 93.20% (96/103), specificity of 70.37% (19/27), and accuracy of 88.46% (115/130). There were no significant differences in the detection rate of joint gap stenosis, joint cavity free body, osteogenic hyperplasia, altered synovial thickening, ligament degeneration, meniscus degenerative injury, and joint effusion between the two examination methods (P>0.05). There was no significant difference in graded of the cartilage injury between the two examination methods (P>0.05). Conclusion MRI examination assessed knee degenerative osteoarthritis articular cartilage damage was similar to arthroscopy, and the sensitivity and specificity of MRI were also high.
		2021 Vol. 28 (34): 158-161 [Abstract] ( 38 ) HTML (36 KB) PDF (0 KB) ( 8 )

	162	Effect of Desloratadine Citrate Disodium in the treatment of chronic urticaria
		ZHANG Chao; ZHANG Lin-lin;DAI Wei-wei; LIU Hong▲
		Objective To explore the effect of Desloratadine Citrate Disodium on chronic urticaria. Methods A total of 100 patients with chronic urticaria who were admitted to the Department of Dermatology of Jiujiang First People′s Hospital from January 2019 to January 2021 were selected as subjects and divided into the control group and the study group by the random number table method, with 50 patients in each group. The control group was treated with Loratadine Tablets, and the study group was treated with oral Desloratadine Citrate Disodium Tablets. Both groups were treated continuously for 28 days. The total score, pruritus score, wheal number, wheal size, total effective rate of different treatment courses and the levels of transforming growth factor-β1 (TGF-β1), immunoglobulin E (IgE), T cell subsets and interleukin-18 (IL-18) were compared between the two groups before treatment, 14 and 28 days after treatment. Results The pruritus scores, wheal number scores, wheal size scores and total scores of the two groups at 14 and 28 d after treatment were lower than those before treatment, with statistically significant differences (P<0.05). The pruritus score, wheal number score, wheal score and total score of the study group were all lower than those of the control group at 14 and 28 d after treatment, with statistically significant differences (P<0.05). In the two groups, the total effective rates at 28 d after treatment were higher than those at 14 d after treatment, with statistically significant differences (P<0.05). The total effective rates in the study group were higher than those in the control group at 14 and 28 d after treatment, with statistically significant differences (P<0.05). The TGF-β1, IgE, IL-18 and CD8+ in the two groups at 14 and 28 d after treatment were lower than those before treatment, with statistically significant differences (P<0.05). The TGF-β1, IgE IL-18 and CD8+in the study group were lower than those in the control group at 14 and 28 d after treatment, with statistically significant differences (P<0.05).The levels of CD4+ and CD4+/CD8+ in the two groups at 14 and 28 d after treatment were higher than those before treatment, with statistically significant differences (P<0.05).The levels of CD4+ and CD4+/CD8+ in the study group were higher than those in the control group at 14 and 28 d after treatment, with statistically significant differences (P<0.05). Conclusion Desloratadine Citrate Disodium can effectively regulate the levels of serum TGF-β1, IgE, IL-18 and T cell subsets of CD4+, CD8+, and CD4+/CD8+ in patients with chronic urticaria, showing good clinical efficacy.
		2021 Vol. 28 (34): 162-166 [Abstract] ( 35 ) HTML (43 KB) PDF (0 KB) ( 8 )

	167	Effect of Yupingfeng Granule on recurrent respiratory tract infection in children
		LIANG Jin-hua ;ZHAO Yu-jing; ZHAN Shao-hua ;XU Jun-jie
		Objective To investigate the therapeutic effect of Yupingfeng Granule on recurrent respiratory tract infection in children. Methods A total of 100 children with recurrent respiratory tract infection admitted to Jingdezhen First People′s Hospital from May 2019 to May 2020 were selected as the research objects, and were divided into observation group (50 cases) and control group (50 cases) by random number table method. The control group was treated with conventional treatment, and the observation group was treated with Yupingfeng Granule on the basis of the control group.The treatment effect, occurrence of respiratory tract infection, symptom improvement time and blood indicators of the two groups were compared. Results The total effective rate of observation group was 98.00%, higher than 86.00% of control group, the difference was statistically significant (P<0.05). The total incidence rate of respiratory tract infection in the observation group was 24.00%, lower than that in the control group (44.00%), and the difference was statistically significant (P<0.05). The improvement of fever, cough and pharyngeal red symptoms and the disappearance of lung rales in the observation group were shorter than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in serum immunoglobulin level between the two groups before treatment (P>0.05). After treatment, the levels of IgG, IgA and IgM in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion In the treatment of recurrent respiratory tract infection in children, the addition of Yupingfeng Granule on the basis of conventional symptomatic treatment can further improve the curative effect and shorten the improvement time of symptoms.
		2021 Vol. 28 (34): 167-169转176 [Abstract] ( 43 ) HTML (32 KB) PDF (0 KB) ( 7 )

	170	Effect of antibiotic supervision and management in ICU
		LI Qiu-ju;ZHU Ya-rong;PENG Guo-liang
		Objective To explore the application effect of antibiotics supervision and management in ICU.Methods A total of 150 patients admitted to ICU, People′s Hospital of Yingde, Guangdong Province from January 2014 to January 2015 were selected retrospectively as the control group, and 150 patients admitted from February 2015 to February 2016 were selected as the intervention group. Routine management of the use of antibiotics was carried out in the control group, and supervision and management of antibiotics was carried out in the intervention group. The utilization rate, use intensity, microbial specimen submission rate and occurrence of drug-resistant bacteria infection were compared between the two groups. Results The utilization rate of antibiotics in the intervention group was lower than that in the control group, and the difference was statistically significant (P<0.05). The intensity of antibiotics use in the intervention group was (159.84±18.04) DDDs/(100 person·days), lower than that in the control group (215.37±22.86) DDDs/(100 person·days), and the difference was statistically significant (P<0.05). The rate of microbiological specimen submission was 72.13% in ICU of the intervention group, which was higher than 46.94% in the control group, and the difference was statistically significant(P<0.05).The incidence of drug-resistant bacteria infection in the intervention group was 2.67%,lower than 8.00% in the control group, and the difference was statistically significant (P<0.05). Conclusion The monitoring and management of antibiotics in ICU ward can reduce the frequency and intensity of antibiotics use, effectively improve the rate of microbial specimen submission, and reduce the occurrence of multi-drug resistant bacteria infection.
		2021 Vol. 28 (34): 170-172 [Abstract] ( 39 ) HTML (31 KB) PDF (0 KB) ( 6 )

	173	Clinical effect of Aripiprazole and Risperidone in the treatment of schizophrenia and comparison of their effect on glucose and lipid metabolism
		QU Jin-mei
		Objective To explore the clinical effect of Aripiprazole and Risperidone in the treatment of schizophrenia and comparisons of their effect on glucose and lipid metabolism. Methods Seventy patients with schizophrenia in Jiuquan People′s Hospital from June 2018 to August 2019 were selected as the research subjects. They were divided into a control group and an observation group by the random number table method, with 35 cases in each group. The patients in the control group were treated with Risperidone, and the patients in the observation group were treated with Aripiprazole. The blood glucose, blood lipid levels and clinical efficacy of the two groups of patients were compared.Results Before treatment, there were no statistically significant differences in the levels of fasting blood glucose (FBG)or 2-hour postprandial glucose (2 h PG) between the two groups (P>0.05). After treatment, the FBG and 2 h PG levels of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). The levels of FBG and 2 h PG in the two groups after treatment were higher than those before treatment, the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in the levels of cholesterol (TC), triacylglycerol (TG), or low-density lipoprotein cholesterol (LDL-C) between the two groups. After treatment, the levels of TC, TG and LDL-C in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The HDL-C level of observation group was higher than that in the control group after treatment, the difference was statistically significant (P<0.05). The total effective rate of observation group was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusion Compared with Risperidone, Aripiprazole has a significant effect on treating patients with schizophrenia, and can remarkably improve the blood glucose and blood lipid levels, which is worthy of promotion.
		2021 Vol. 28 (34): 173-176 [Abstract] ( 42 ) HTML (32 KB) PDF (0 KB) ( 9 )

	177	Application of Rosuvastatin combined with Probucol in the treatment of carotid atherosclerotic plaque and its effect on inflammatory factors in patients
		LIU Zhi-gang
		Objective To explore the application of Rosuvastatin combined with Probucol in the treatment of carotid atherosclerotic plaque and its effect on inflammatory factors in patients. Methods A total of 720 patients with carotid atherosclerotic plaque who were diagnosed and treated in the Dalian Central Hospital, Liaoning Province from May 2014 to May 2020 were selected as the research subjects. They were divided into an observation group (n=360) and a control group (n=360) by the random number table method. The patients in the control group were treated with Rosuvastatin,and in the observation group were treated with Rosuvastatin combined with Probucol. The plasma oxidized low-density lipoprotein and carotid intima-media thickness, levels of inflammatory factors and the occurrence of adverse reactions of the two groups were compared before and after treatment. Results The plasma oxidized low-density lipoprotein level and carotid artery intima-media thickness of the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, with statistical significance (P<0.05). The levels of inflammatory factors including hypersensitive C-reactive protein, interleukin-6, and matrix metalloproteinase-9 in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The combination of Rosuvastatin and Probucol has a significant effect in the treatment of carotid atherosclerotic plaque, which can reduce the levels of inflammatory factors, and is worthy of clinical application.
		2021 Vol. 28 (34): 177-179 [Abstract] ( 36 ) HTML (30 KB) PDF (0 KB) ( 6 )

	180	Cognition and countermeasures of oral health status of college freshmen
		ZHANG Jia-yang ;AISHAN Abdusalam; ZHAO Jing-wen; HU Yu-ya ;LIU Zhi-huan; ZHANG Ming▲
		Objective To understand the oral health status and cognition of college freshmen, and to provide reference for the formulation of oral health education strategies for college students, so as to promote the development of oral health of young students. Methods In December 2020, a random sampling method was adopted to carry out the survey,and 652 freshmen enrolled in 2020 nationwide were selected as the survey objects. A questionnaire was designed to investigate the oral health status, cognitive status and health behavior of college freshmen in different areas by issuing electronic questionnaires. Results A total of 700 questionnaires were distributed, and 652 effective questionnaires were actually recovered. Among the respondents, 406 (66.27%) had suffered from oral diseases, 530 (81.29%) had not received regular oral examinations, and 400 (61.35%) did not know the impact of dental plaque on oral health. Three hundred and forty-seven respondents mainly obtained oral health knowledge from family members, accounting for 53.22%, followed by online media (51.07%) and oral doctors (47.70%). Conclusion The respondents have low cognition of oral professional knowledge, some oral health behaviors need to be corrected, and oral health education needs to be improved professionally and innovatively.
		2021 Vol. 28 (34): 180-183 [Abstract] ( 47 ) HTML (33 KB) PDF (0 KB) ( 7 )

	184	Study of the community residents on the utilization suitable technology of traditional Chinese medicine and the influencing factors
		ZENG Xue-qin; YU Wei; HUANG Xiao▲
		Objective To explore the community residents on the utilization suitable technology of traditional Chinese medicine and the influencing factors. Methods The stratified sampling method was used to select some residents of local communities in Sichuan Province from September 2019 to April 2020 (Class I region: Chengdu, Class II region:Luzhou and Yibin, Class Ⅲarea: Ngawa) to carry out questionnaire survey, including general demographic characteristics, use and use of appropriate traditional Chinese medicine technology. Results A total of 478 valid questionnaires were retrieved, and 65.9% of the respondents had used appropriate Chinese medicine techniques. Traditional Chinese medicine therapy (46.2%) and acupuncture therapy (19.5%) were widely used. The results of univariate analysis showed that the use of traditional Chinese medicine at different ages, education and perceived health status (P<0.05). The results of the multivariate analysis showed that age, education, and perceived health are related factors affecting the utilization of appropriate traditional Chinese medicine technologies by community residents (P<0.05). Conclusion The development and promotion of appropriate technology of traditional Chinese medicine in Sichuan Province has achieved certain results, but the overall utilization rate and use types of residents still need to be improved.
		2021 Vol. 28 (34): 184-187 [Abstract] ( 44 ) HTML (35 KB) PDF (0 KB) ( 8 )

	188	Investigation on Physical Fitness of Preschool Children Aged 3-4 in Pingxiang City from 2017 to 2019
		ZHOU Li;YI Kai-wei;LIU Qi-yun; OUYANG Si-hong
		Objective To investigate the physical fitness of preschool children aged 3-4 years in Pingxiang City from 2017 to 2019. Methods Atotal of 2203 cases of 3-4 years old preschool children admitted to Pingxiang City Maternal and Child Health Care Hospital from January 2017 to December 2019 were selected as the research objects. According to gender, they were divided into male group (1167 cases) and female group (1036 cases). Counted the comprehensive physical fitness scores of the two groups of children, analyzed the comprehensive ratings and various physical fitness indicators of children of different ages. Results From January, 2017 to December, 2019, among preschool children aged 3-4 years in Pingxiang area, the overall physical performance of male students accounted for 13.96%, the passing rate was 63.67%, the good rate was 18.25%, and the excellent rate was 4.11%. The overall physical performance of girls failed 10.81%, passed 57.24%, good 25.10% and excellent 6.85%. Among them, the failure rate and passing rate of male students are higher than that of female students, while the good rate and excellent rate of male students are lower than that of female students. The excellent rate and good rate of children aged 3-4 increased gradually, while the passing and failing rates decreased gradually. The values of height, weight, standing long jump and tennis throw distance of boys and girls aged 3-4 years all increased with age, while the values of 10-meter turn-back, continuous jumping with both feet, sitting forward flexion and walking balance beam all decreased with age, and the difference was statistically significant (P<0.05). Conclusion Through the analysis of preschool children′s physique in Pingxiang area, it is convenient to give effective guidance for children′s physique in the future, help to improve children′s physique and promote their all-round development.
		2021 Vol. 28 (34): 188-190转195 [Abstract] ( 29 ) HTML (33 KB) PDF (0 KB) ( 7 )

	191	Research of postoperative complications and the risk factors for gastric cancer
		LIU Fu-quan;CHANG Ying;ZHANG Di-kang;SONG Fang-hua▲
		Objective To explore the postoperative complications and the risk factors for gastric cancer. Methods A retrospective analysis of the clinical data of 508 postoperative patients with gastric cancer admitted to Xinhua Hospital Affiliated to Dalian University, Dalian Third People′s Hospital, and Joint Logistics Support Force of PLA No.967 Hospital from January 2010 to May 2020, According to whether postoperative complications occurred, they were divided into complication groups (n=71) and non-complication group (n=437). In the univariate analysis, the factors that were significantly different between the complication group and the uncomplicated group were included in the multivariate logistic regression analysis to analyze whether they were related risk factors. Results Seventy-one of the 508 patients with gastric cancer had postoperative complications, with a postoperative complication rate of 13.98%, with the highest incidence of incision infection and lung infection, with 2.36% and 1.77%, respectively. The results of univariate analysis showed that age of onset, preoperative comorbidities, prognostic nutrition index, surgical scope and surgical experience were the factors related with the occurrence of postoperative complications (P<0.05). The results of the multivariate analysis found that the preoperative comorbidity and prognostic nutrition index were the risk factors for the occurrence of postoperative complications (OR=3.12, 3.48; 95%CI=2.09-4.65, 2.11-5.75). Chief surgeon with 151-250 and >250 surgical experience were protective factors for the occurrence of postoperative complications (OR=0.69, 0.59;95%CI=0.54-0.88, 0.39-0.90). Conclusion Related risk factors for postoperative complications of gastric cancer patients include preoperative complications, prognostic nutritional index and surgical experience. Fully evaluate the condition before surgery, actively treat medical diseases, and improve nutritional status; during the operation, it is necessary to remove the lesion as much as possible, but also to reduce unnecessary damage, reduce the incidence of postoperative complications, and promote the prognosis of the patient.
		2021 Vol. 28 (34): 191-195 [Abstract] ( 35 ) HTML (38 KB) PDF (0 KB) ( 9 )

	196	Effect of individualized comprehensive nursing combined with low frequency electrical stimulation and open plugs anal treatment for postpartum urinary retention
		CHEN Yi;XIE Shui-lan; LIU Li-juan
		Objective To observe the effect of individualized comprehensive nursing care combined with low frequency electrical stimulation and open plugs anal treatment for postpartum urinary retention. Methods From March 2020 to March 2021, 80 parturients with urinary retention after natural childbirth in Ruijin Maternal and Child Health Hospital in Jiangxi Province were selected and divided into two groups by random number table, 40 cases in each group. The control group was intervened by basic nursing, hot compress on abdomen, massage on abdomen and indwelling catheter,while the observation group was intervened by individualized comprehensive nursing combined with low-frequency electrical stimulation, tamponade and anal tamponade. The first micturition time, 24 hour postpartum hemorrhage volume, nursing satisfaction of two groups were compared. Results The first micturition time in observation group was shorter than that in control group, the difference was statistically significant (P<0.05). 24 hours postpartum hemorrhage in observation group was less than that in control group, the difference was statistically significant (P<0.05). Nursing total satisfaction of observation group was higher than that of control group, and the difference was statistically significant(P<0.05). Conclusion For patients with postpartum urinary retention, individualized comprehensive nursing care combined with low frequency electrical stimulation and open plugs anal treatment has significant effect, promoting patients to urinate at the same time, reduce the 24 hours postpartum hemorrhage, and enhance patient satisfaction, which is worthy of clinical promotion.
		2021 Vol. 28 (34): 196-198 [Abstract] ( 43 ) HTML (29 KB) PDF (0 KB) ( 8 )

	199	Application effect of evidence-based nursing in sequential mechanical ventilation treatment
		PENG Lin-min; LIU Jian; LIU Qing
		Objective To explore the application effect of evidence-based nursing in sequential mechanical ventilation therapy. Methods A total of 150 critically ill patients admitted to the Second Affiliated Hospital of Nanchang University from February 2019 to February 2020 were selected as the research subjects. They were divided into the routine group(75 cases)and the observation group(75 cases)by grasping the ball.Routine nursing was used in the routine group,and evidence-based nursing was applied in the observation group. The blood gas indicators including blood oxygen saturation, blood oxygen partial pressure, blood carbon dioxide partial pressure, ventilation time, hospital stay, and adverse events including ventilator-associated pneumonia (VAP), unplanned extubation, medical disputes, and complaints were compared between the two groups. Results Before the intervention, there were no statistically significant difference in blood gas indicators between the two groups(P＞0.05).After the intervention,the blood oxygen saturation and partial pressure of oxygen in the observation group were higher than those in the control group, and the partial pressure of carbon dioxide in the observation group was lower than the control group, with statistical differences (P<0.05). The mechanical ventilation time and hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The incidence of VAP, unplanned extubation, medical disputes, and complaints in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Evidence-based nursing can improve the blood oxygen saturation of patients treated by sequential mechanical ventilation, increase the partial pressure of blood oxygen, reduce the partial pressure of carbon dioxide, shorten the time of mechanical ventilation and hospital stay, and reduce the incidence of VAP and other adverse events.
		2021 Vol. 28 (34): 199-201转205 [Abstract] ( 40 ) HTML (32 KB) PDF (0 KB) ( 6 )

	202	Clinical effect of modified acupoint application on chronic aplastic anemia
		XIAO Zi-wei;HE Ya-na▲
		Objective To explore the clinical effect of improved acupoint application on chronic aplastic anemia（CAA）. Methods From October 2020 to April 2021 in the First Affiliated Hospital of Hunan University of Chinese Medicine,60 patients with CAA were selected as the research subjects.They were divided into the control group (30 cases) and the observation group (30 cases) by random sampling. The control group was treated with conventional treatment and nursing, and the observation group was treated with improved acupoint application on the basis of control group.Blood image changes, effective rate and satisfaction of the two groups were compared, and the incidence of adverse reactions (skin allergy, skin damage, blisters, drug peelings) in the observation group was recorded. Results Fifty-nine cases were completed, including 29 cases in the control group and 30 cases in the observation group. After treatment,the numbers of hemoglobin, white blood cell and platelet in both groups were higher than before treatment, and the observation group was higher than those of the control group,with statistical differences (P<0.05).The total effective rate and efficiency between the two group, with no statistical significances (P＞0.05). The total satisfaction of the observation group was higher than that of the control group, with statistical difference (P<0.05). The incidence of ADR in observation group was low than that of the control group,the difference was statistically significant (P <0.05).Conclusion The improved acupoint application in the treatment of patients with CAA has good curative effect,high satisfaction and low incidence of adverse reactions.
		2021 Vol. 28 (34): 202-205 [Abstract] ( 38 ) HTML (35 KB) PDF (0 KB) ( 6 )

	206	Discussion on the application value of comfortable nursing to prevent stress response in patients undergoing hysteroscopy
		ZHAO Su-li
		Objective To explore the effect of comfortable nursing on preventing stress response in patients undergoing hysteroscopy. Methods A total of 106 patients who underwent hysteroscopy in the Ji′an Maternity and Child Health Hospital from April 2018 to April 2019 were selected as the research subjects. The patients were divided into the control group (n=53) and the observation group (n=53) by random number table method. Patients in the control group were provided with routine care, and patients in the observation group were provided with comfortable nursing. The physiological indicators such as blood pressure (BP), heart rate (HR), adrenaline (AD), norepinephrine (NE) and psychological stress response such as self-rating anxiety scale (SAS) and self-rating depression scale (SDS) of the two groups were compared before and 10 min after examination. Results There were no statistically significant difference in the physiological and psychological stress response between the two groups before the intervention (P＞0.05). After intervention in the observation group, systolic blood pressure (SBP), diastolic blood pressure （DBP）, HR, AD, and NE were (137.03±15.19) mmHg, (88.13±6.29) mmHg, (80.21±10.28) beats/min, (90.05±10.04) pmol/L and (160.32±18.41) pmol/L, all lower than those of the control group of (146.35±15.84) mmHg, (95.37±6.54) mmHg, (93.18±10.35) beats/min, (102.33±12.18) pmol/L, (172.65±18.94) pmol/L, with statistical differences (P<0.05). The SAS and SDS scores of the observation group after intervention were (26.98±4.57) points and (25.13±3.26) points, lower than those of the control group of(35.17±4.63) points and (30.16±3.37) points respectively, with statistical differences (P<0.05). Conclusion Comfortable nursing can reduce the physiological and psychological stress response of patients undergoing hysteroscopy, relieve patients′negative emotions, and effectively ensure patients′safety.
		2021 Vol. 28 (34): 206-208转211 [Abstract] ( 42 ) HTML (30 KB) PDF (0 KB) ( 9 )

	209	Risk assessment classification combined with comfort education in the prevention of childbirth risks and its effects on the choice of childbirth methods
		WANG Zhi-hong; XU Han-xiu;LIU Ling-zhen
		Objective To explore the risk assessment classification combined with comfort education in the prevetion of childbirth risks and its effects on the choice of childbirth methods. Methods A total of 90 expectant puerperae who were admitted to the Fuzhou Institute of Medical Sciences from July 2018 to February 2020 were selected as the study subjects. According to the random number method, they were divided into the control group (45 cases) and the trial group (45 cases). The control group was given conventional nursing methods, and the trial group was given a risk assessment classification method combined with comfort education for intervention. Both groups were given nursing care for 15 weeks. The delivery methods, neonatal outcomes and nursing satisfaction were compared between the two groups.Results The normal delivery rate of puerperae in the trial group was higher than that of the control group, and the difference was statistically significant (P<0.05). The total incidence rate of neonatal outcomes in the trial group was lower than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in satisfaction between the two groups (P＞0.05). Conclusion The risk assessment classification combined with comfort education can reduce the risk of childbirth, improve the level of childbirth, and improve the satisfaction of puerperae with the nursing work.
		2021 Vol. 28 (34): 209-211 [Abstract] ( 39 ) HTML (27 KB) PDF (0 KB) ( 8 )

	212	Effect of new assisted breastfeeding pillow supplemented with breastfeeding in latericumbent posture on exclusive breastfeeding rate and breastfeeding efficiency of puerperae undergoing cesarean section
		SU Xi-lan
		Objective To explore the effect of new assisted breastfeeding pillow supplemented with breastfeeding in latericumbent posture on exclusive breastfeeding rate and breastfeeding efficiency of puerperae with cesarean section.Methods A total of 105 women who underwent cesarean seetion in Yichun Maternal and Child Health Hospital were selected from January 2019 to October 2020, and they were divided into control group (n=52) and observation group(n=53) by the lottery method. The control group were given breastfeeding in latericumbent posture without intervention,and the observation group applied new assisted breastfeeding pillow supplemented with breastfeeding in latericumbent posture. On the 1 and the 42 days after delivery, the feeding methods (exclusive breastfeeding, pure artificial feeding,mixed feeding), breastfeeding efficiency (breastfeeding self-efficacy scale [BSES]) and the occurrence of breastfeeding complications (chapped nipples, breast distending pain) of the two groups were compared. Results The rate of exclusive breastfeeding on the 42 days after delivery in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The BSES score on the 42 days postpartum of the observation group was higher than that on the 1 day postpartum, and the BSES score of the observation group on the 42 days postpartum was higher than that of the control group, the difference was statistically significant (P<0.05). The total incidence of breastfeeding complications on the 42 day postpartum in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion New assisted breastfeeding pillow supplemented with breastfeeding in latericumbent posture can effectively enhance the exclusive breastfeeding behaviors, increase the exclusive breastfeeding rate, improve the breastfeeding performance, and prevent the occurrence of complications such as breast distending pain and chapped nipples in puerperae undergoing cesarean section.
		2021 Vol. 28 (34): 212-214 [Abstract] ( 38 ) HTML (31 KB) PDF (0 KB) ( 6 )

	215	Application effect of postoperative pain control combined with responsibility for holistic nursing in elderly patients with intertrochanteric fracture of femur after operation
		LAI Zhi-hong;WANG Xiao-hong; SONG Chang-qing
		Objective To explore the application effect of postoperative pain control combined with responsibility for holistic nursing in elderly patients with femoral intertrochanteric fractures after surgery. Methods Eighty elderly patients with femoral intertrochanteric fractures from January 2018 to January 2020 treated in Ruijin People′s Hospital,Jiangxi Province were selected as the research subjects. They were divided into the control group (40 cases) and the experimental group (40 cases) using random number table method. Patients in the control group underwent responsibility for holistic nursing intervention and in the experimental group, patients underwent postoperative pain control combined with responsibility for holistic nursing. The nursing satisfaction, the improvement effect of hip joint function and the patient′s pain degree were compared. between two groups. Results After nursing, the pain score of the experimental group was lower than that of the control group, the difference was statistically significant (P<0.05). The nursing satisfaction degree of the experimental group was 90.00%, which was higher than 75.00% of the control group, the difference was statistically significant (P<0.05). After nursing, the hip joint function score of the experimental group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion Patients with femoral intertrochanteric fractures receiving postoperative pain control and responsibility for holistic nursing will help to improve the patients′ nursing effect, alleviate pain, improve hip joint function, and increase nursing satisfaction, which have a high overall application value.
		2021 Vol. 28 (34): 215-217 [Abstract] ( 40 ) HTML (30 KB) PDF (0 KB) ( 9 )

	218	Influence of cognitive behavioral nursing model on psychological state and self-efficacy of breast cancer patients undergoing chemotherapy
		LE Li-fang ;FENG Jing
		Objective To study the influence of cognitive behavioral nursing model on psychological status and self-efficacy of breast cancer patients undergoing chemotherapy. Methods From October 2018 to October 2020, 78 patients with breast cancer chemotherapy admitted to the First People′s Hospital of Fuzhou City, Jiangxi Province were selected as the research objects, and they were divided into the control group (39 cases) and the observation group (39 cases) using random number table method. Patients in the control group were treated with routine care, and patients in the observation group were combined with a cognitive behavioral care model on the basis of routine care. Both groups were given nursing for 5 months. The changes of cognitive function, mental state and self-efficacy of the two groups of patients before and after nursing were compared. Results The scores of cognitive ability, correction of cognitive impairment, self-decompression, self-decision-making, and positive attitudes of the two groups of patients after nursing were higher than those of before nursing, the scores on cognitive ability, correction of cognitive impairment, self-decompression, self-decision-making, and positive attitude of the observation group after nursing were higher than those of the control group, the differences were statistically significant (P<0.05). The scores of nervousness, depression and panic of the two groups of patients were lower than those of before nursing, the scores of nervousness, depression and panic in the observation group after nursing were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Cognitive behavior nursing model can improve the psychological state of breast cancer patients with chemotherapy, improve self-efficacy and cognitive function, and the nursing effect is significant.
		2021 Vol. 28 (34): 218-220 [Abstract] ( 44 ) HTML (30 KB) PDF (0 KB) ( 10 )

	221	Application of information-based continuous nursing in the treatment of phimosis with prepuce retractor
		ZHONG Yan
		Objective To study the application of information-based continuation nursing in the treatment of phimosis with a foreskin retractor. Methods From September 2019 to September 2021, 50 children with phimosis who underwent a foreskin retractor in the Pingxiang Third People′s Hospital and Ganxi Hospital were selected and divided into the control group (n=25) and the test group (n=25) according to the random number table method .Children in the control group received routine nursing care. On the basis of the control group, the children in the test group were combined with information-based continuous nursing care. Both groups were nursing for 2 weeks and followed up for 2 weeks.The number of outpatient visits, cure time, satisfaction, compliance and complications during nursing were compared between the two groups. Results The number of outpatient visits in the test group was less than that in the control group, cure time was shorter than that in the control group, and the satisfaction score was higher than that of the control group, the differences were statistically significant (P<0.05）. During the nursing period, the total compliance of the test group (88.00%) was higher than that of the control group (52.00%), the difference was statistically significant (P<0.05),and the total incidence of complications in the test group (4.00%) was lower than that of the control group (28.00%),the difference was statistically significant (P<0.05). Conclusion Information-based continuous nursing can effectively improve the compliance of children in the treatment of phimosis with a foreskin retractor, and at the same time can reduce the occurrence of complications, improve overall satisfaction, and have a better application effect.
		2021 Vol. 28 (34): 221-223 [Abstract] ( 41 ) HTML (30 KB) PDF (0 KB) ( 9 )

	224	Application of intervention mode based on protection motivation theory in infection patients of HIV/AIDS sero-discordant couples
		ZHANG Li-man; XU Li
		Objective To explore the application of intervention mode based on protection motivation theory protection motivation theory, PMT in infection patients of human immunodeficiency virus/acquired immunodeficiency syndrome,(HIV/AIDS) sero-discordant couples. Methods A total of 120 infection patients of HIV/AIDS sero-discordant couples confirmed in Nanjing Hospital Affiliated to Nanjing University of Traditional Chinese Medicine were selected as the research objects from December 2019 to December 2020. According to random number table method, they were divided into the control group (n=60) and the observation group (n=60). The control group was given routine nursing, while the observation group was additionally given nursing interventions based on PMT. After 6 months of intervention, selfmanagement behaviors, self-efficacy, usage rate of condoms, detection rate of spouses and counts of CD4 cells/viral load in both groups were evaluated. Results The usage rate of condoms and count of CD4 cells in the observation group were higher than those in control group, and the differences were statistically significant (P<0.05). There were no significant difference in the scores of self-management and self-efficacy between the two groups before intervention (P＞0.05). The scores of self-management and self-efficacy in both groups after intervention were higher than those before intervention (P<0.05), and the scores of self-management and self-efficacy in the observation group after intervention were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion The clinical intervention mode based on PMT can significantly improve self-management behaviors, self-efficacy, safe sexual behaviors, spouse detection rate and count of CD4 cells, and reduce count of viral load in infection patients of HIV/AIDS sero-discordant couples.
		2021 Vol. 28 (34): 224-226转230 [Abstract] ( 44 ) HTML (32 KB) PDF (0 KB) ( 9 )

	227	Clinical Nursing Analysis of Sputum Suction with Fiberoptic Bronchoscope to Treat Severe Pulmonary Infection
		KANG Hui-zhen
		Objective To evaluate the effect of high quality nursing in the treatment of severe pulmonary infection by sputum suction under fiberoptic bronchoscope. Methods A total of 92 patients with severe pulmonary infection treated in Xiamen Hospital of Traditional Chinese Medicine from June 2018 to June 2020 were selected as the research object.They were divided into control group (46 cases) and observation group (46 cases) according to the random number table method. The control group received routine nursing, and the observation group received high-quality nursing intervention on the basis of the control group. The disappearance time of symptoms, length of hospital stay and complications were compared between the two groups. Results The cough disappearance time, wet rales disappearance time, and hospital stay in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05). The nursing satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion The application of high-quality nursing in the treatment of severe pulmonary infection by sputum suction through fiberoptic bronchoscope can promote the recovery of clinical symptoms, shorten the length of hospital stay, reduce complications and promote the rehabilitation of patients.
		2021 Vol. 28 (34): 227-230 [Abstract] ( 37 ) HTML (31 KB) PDF (0 KB) ( 9 )

	231	Research on the psychological status of patients with assisted reproductive infertility adopting humanistic care
		JIANG Juan-juan ；JIANG Fan
		Objective To explore the influence of humanistic care on the psychological state and diagnosis and treatment experience of patients with assisted reproductive therapy. Methods From June to December 2019, 60 infertile patients with assisted reproductive therapy in Zhangzhou Hospital were selected as the research objects, and they were divided into the observation group and the control group by computer digital random model, 30 patients in each group.The observation group was given humanistic care, while the control group was given routine care. The psychological status and quality of life of the two groups were compared. Results The positive emotion index, and the short-form 36 item health survey questionnaire (SF-36) of the two groups after treatment were higher than those before treatment,negative emotion index was lower than before nursing, and the positive emotion index, and SF-36 quality of life index of the observation group were higher than those of the control group, negative emotion index was lower than that of the control group, the differences were statistically significant (P<0.05). Conclusion Humanistic care has the characteristics of meticulous, comprehensive and intimate, which is helpful for patients with assisted reproductive infertility, can effectively inhibit negative emotions and improve the pregnancy rate, and the scheme is worthy of promotion.
		2021 Vol. 28 (34): 231-233 [Abstract] ( 42 ) HTML (29 KB) PDF (0 KB) ( 8 )

	234	Application effects of perioperative care in congenital bowel atresia
		XUE Rui-yun ;WU Li-juan ;HUANG Wen-hua▲
		Objective To investigate the application effect of perioperative care in congenital intestinal atresia. Methods A total of 113 children with congenital intestinal atresia treated in Fujian Maternal and Child Health Hospital from December 2015 to December 2020 were selected as study subjects, and the single double number on the admission date of the child was used to divide them into the control (n=56) and the observation group (n=57). Childrens in the control group were treated with routine nursing, while childrens in the observation group were treated with perioperative nursing. The nursing effect, secondary operation rate, complication rate, and length of hospital stay were compared between the two groups, and the parents′ satisfaction with nursing work was analyzed. Results The total effective rate of nursing in the observation group was higher than that in the control group, the difference was statistically significant(P<0.05); the total incidence of complications in the observation group was lower than those in the control group, and the difference was statistically significant (P<0.05); secondary surgery rate in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). The length of hospitalization of the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05); total satisfied nursing of the parents of children in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion The application of a positive and effective perioperative nursing intervention for children with surgical treatment of congenital intestinal atresia has a significant effect, reduce the occurrence of complications, and promote rehabilitation, and the children′s parents have greater recognition of this care model, which is worth clinical promoting.
		2021 Vol. 28 (34): 234-237 [Abstract] ( 23 ) HTML (37 KB) PDF (0 KB) ( 9 )

	238	Effect of strengthening health education in nursing of children with asthma
		ZOU Hui-rong; YE Cui-fen
		Objective To study the effect of strengthening health education in the nursing of children with asthma.Methods A total of 100 patients with asthma treated in Fuzhou Children′s Hospital Affiliated to Fujian Medical University from December 2018 to February 2020 were selected as the research objects. They were divided into the observation group (50 cases) and the control group (50 cases) by drawing lots at random. The observation group adopted the method of intensive health education and the control group adopted the method of routine health education. The forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEFR) index, compliance,number of asthma attacks and length of hospital stay were compared between the two groups. Results After nursing,FEV1 was (1.87±0.34) l, FVC was (2.24±0.45) l and PEFR was (3.46±1.02) l/s in the observation group, higher than those in the control group, the differences were statistically significant (P<0.05). The medication total compliance of asthmatic children in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). The number of asthma attacks was (2.52±1.01) and the length of hospital stay was (5.32±1.20)days in the observation group, were shorter than those in the control group, the differences were statistically significant(P<0.05). Conclusion The application of intensive health education in the nursing of children with asthma has a significant effect, which can significantly improve their pulmonary function indexes, reduce the number of asthma attacks and shorten the hospital stay of children.
		2021 Vol. 28 (34): 238-240 [Abstract] ( 48 ) HTML (29 KB) PDF (0 KB) ( 7 )

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