微小RNA- 365 在高血压心肌肥厚患者中的表达及其与血压、左心室质量指数的相关性

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective Analysis the expression of microRNA-365 (miRNA-365) and correlation with blood pressure and left ventricular mass index in the plasma of patients with hypertensive myocardial hypertrophy. Methods A total of 100 patients with hypertension admitted to the First Affiliated Hospital of Gannan Medical University from June 2020 to February 2021 were selected as the research subjects, patients with hypertension complicated with left ventricular hypertrophy were divided into observation group (50 cases), patients with simple hypertension were divided into control group 2 (50 cases), and 50 healthy subjects who underwent physical examination at the same period were selected as control group 1. Ambulate blood pressure, clinic blood pressure and color doppler echocardiography were performed in all three groups. The expression of circulating miRNA-365 was detected by reverse transcription polymerase chain reaction (RT-PCR), and the correlation between miRNA-365 expression level and blood pressure parameters and left ventricular mass index was analyzed. Results The dynamic blood pressure, daytime blood pressure, clinic blood pressure and left ventricular mass index of the observation group were higher than those of control group 1 and control group 2, the differences were statistically significant (P<0.05). The expression level of miRNA-365 in observation group(1.22±0.31) was higher than that in control group 1 (0.84±0.16) and control group 2 (1.02±0.27), the differences were statistically significant (P<0.05). Pearson analysis showed that miRNA-365 expression was positively correlated with ambulate blood pressure (24 h mean systolic pressure, 24 h mean diastolic pressure, 24 h mean pulse pressure) and left ventricular mass index (P<0.05). There was no significant correlation with daytime blood pressure (daytime systolic blood pressure, daytime diastolic blood pressure, daytime pulse pressure) and office blood pressure (office systolic blood pressure, office diastolic blood pressure, office pulse pressure) (P>0.05). Conclusion miRNA-365 is positively correlated with ambulatory blood pressure and left ventricular mass index in patients with hypertensive myocardial hypertrophy disease, detection of miRNA-365 expression in plasma can assist in the diagnosis of hypertensive myocardial hypertrophy.

Key words： Myocardial hypertrophy Hypertension MicroRNA Left ventricular mass index

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Xu-feng
	ZOU Liang-ying
	HUANG He
	ZHONG Wen-ting
	WANG Bei

Cite this article:

ZHOU Xu-feng,ZOU Liang-ying,HUANG He, et al. Expression of microRNA-365 and correlation with blood pressure and left ventricular mass index in the plasma of patients with hypertensive myocardial hypertrophy[J]. 中国当代医药, 2021, 28(34): 13-16.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I34/13

[1]	权月，田格尔，周骏腾，等.压力超负荷诱导的心肌肥厚/心力衰竭模型鼠肝肾损伤及巨噬细胞活化水平的变化[J].四川大学学报（医学版），2020，51（3）：71-76.
[2]	Bertero E，Maack C.Metabolic remodelling in heart failure[J].Nat Rev Cardiol，2018，15（8）：457-470.
[3]	张震，蔡琳，许金超，等.PRKAG2 基因新突变致心肌肥厚和严重心力衰竭但不合并心律失常的心脏综合征[J].中国分子心脏病学杂志，2019，19（4）：58-61.
[4]	Calore M.The PRKAG2 gene and hypertrophic cardiomyopathy：an energetically imbalanced relationship[J].Am J Physiol Heart Circ Physiol，2017，313（2）：H248-H250.
[5]	鲁悦新，石红杰，欧阳珊，等.卵泡抑素样蛋白4 通过活化T 细胞核因子抑制病理性心肌肥厚的发生发展[J].中国心脏起搏与心电生理杂志，2019，33（3）：240-244.
[6]	Tham YK，Bernardo BC，Ooi JYY，et al.Pathophysiology of cardiac hypertrophy and heart failure：signaling pathways and novel therapeutic targets[J].Arch Toxicol，2015，89（9）：1401.
[7]	周湘鸿，蔡建平，刘伟利，等.循环微小RNA-29b 在高血压左心室肥厚诊断中的价值[J].中华内科杂志，2019，58（4）：278-281.
[8]	黄如彬，王利莎，丁力.老年急性心力衰竭患者血清miR-181b 表达与心功能指标及预后的关系[J].河北医药，2019，41（22）：3448-3450，3454.
[9]	尹涛源，林玲，杨大英，等.微小RNA 对老年冠心病慢性心力衰竭合并高血压的影响[J].中华老年心脑血管病杂志，2020，22（4）：55-58.
[10]	中国高血压防治指南起草委员会.中国高血压防治指南[J].中国卒中杂志，2006，1（8）：575-582.
[11]	郑云松.老年高血压病和冠心病所致左室肥厚患者心脏微血管病变的特点及与心脏事件发生率的关系[J].当代医学，2017，23（7）：114-115.
[12]	Garfinkel AC，Seidman JG，Seidman CE.Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy[J].Heart Fail Clin，2018，14（2）：139-146.
[13]	辛娟娟，赵玉雪，刘群，等.胆碱能抗炎通路介导针刺延缓高血压心肌重构新思路[J].针刺研究，2020，45（9）：78-82.
[14]	王时俊，徐磊，赵刚，等.HSF1 基因缺失通过上调 microRNA-195a-3p 加速压力超负荷下心脏重构[J].中国病理生理杂志，2019，35（3）：385-392.
[15]	Mohammadi M，Sp otin A，Mahami-Oskouei M，et al.MicroRNA-365 promotes apoptosis in human melanoma cell A375 treated with hydatid cyst fluid of Echinococcus granulosus sensu stricto[J].Microb Pathog，2021，10（153）：104.