妊娠期糖尿病与甲状腺功能减退的相关性分析

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (37 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the relationship between hypothyroidism and gestational diabetes mellitus (GDM), to analyze and understand the possible influence of thyroid hormone (TH) on blood glucose levels during pregnancy, and to analyze whether blood glucose will advance hypothyroidism. Methods A total of 664 pregnant women who underwent routine obstetrics at the No. 4 People′s Hospital of Zhanjiang from November 2019 to November 2020 were selected as the research subjects. According to the results of oral glucose tolerance test (OGTT) and thyroid function, 232 patients with GDM and hypothyroidism were selected as group A, 224 pregnant women with simple GDM were selected as group B, and 208 pregnant women with simple hypothyroidism were selected as group C. All pregnant women were tested for related thyroid function: free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-thyroglobulin antibody (TGAb) positive rate and anti-thyroid peroxidase autoantibody (TPOAb) positive rate. Blood glucose indicators such as fasting blood glucose (FPG) and glycosylated hemoglobin (HbA1c), OGTT 1 h, and OGTT 2 h were measured. Blood lipid indicators including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and total cholesterol (TC) were determined. The levels and differences of related thyroid and blood lipid indicators between group A and C were observed and compared. The levels and differences of related thyroid and blood lipid indicators between group A and B were observed and compared. The correlation between related thyroid function indicators and blood glucose indicators in group C and correlation between related thyroid function indicators and blood glucose indicators in group A were explored. Results The levels of FT4, FT3, and HDL in group A were lower than those in group Cwith statistical significance (P<0.05). The TG level in group A was higher than that in group C, and the difference was statistically significant (P<0.05). The HbA1c, TSH, TC, and LDL levels and TPOAb and TGAb positive rates of group A were higher than those of group B with statistical significance(P<0.05). Correlation analysis indicated that there was a negative correlation between OGTT 2 h blood glucose level and FT4 in group C, and the difference was statistically significant (P<0.05). There was a positive correlation between TSH and FBG in group A, and the difference was statistically significant (P<0.05). Conclusion During pregnancy, hypothyroidism will significantly increase the pregnant women′s FBG, OGTT 1 h, and OGTT 2 h levels, and also induce abnormal lipid metabolism. GDM will further aggravate the abnormal thyroid function of pregnant women, and the two will interact with each other.

Key words： Pregnancy Gestational diabetes Glucose metabolism indicator Thyroid function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HUANG Jian-chun

Cite this article:

HUANG Jian-chun. Correlation analysis between gestational diabetes mellitus and hypothyroidism[J]. 中国当代医药, 2021, 28(34): 127-130.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I34/127

[1]	麻伟博，孙彦华，吴秀杰.孕早期甲状腺功能异常与妊娠期糖尿病关系的研究[J].北京医学，2019，41（7）：81-82.
[2]	许波，江碧薇，袁雪蓉，等.妊娠期甲状腺功能异常与妊娠期糖尿病、高血压的患病风险分析[J].中国计划生育学杂志，2019，27（4）：479-483.
[3]	甘毓舒，杨玉综，王燕，等.妊娠期糖尿病合并亚临床甲状腺功能减退患者炎性应激状态及凝血功能对妊娠结局的影响[J].国际生殖健康/计划生育杂志，2019，38（2）：113-115，133.
[4]	Ikegami K，Refetoff S，Cauter EV，et al.Interconnection between circadian clocks and thyroid function[J].Nat Rev Endocrinol，2019，15（10）：590-600.
[5]	陈丽锦，王烨，李娟，等.妊娠期糖尿病与妊娠早期甲状腺功能状态的相关性[J].临床与病理杂志，2020，40（5）：1174-1178.
[6]	Kim SH，Min HK，Lee SW.Relationship between Thyroid and Kidney Function：Analysis from the Korea National Health and Nutrition Examination Survey Between 2013 and 2015[J].Kidney Blood Press Res，2020，45（3）：1-13.
[7]	杜伟平，张瑞，米思蓉，等.妊娠期糖尿病患者糖化血红蛋白水平与甲状腺激素水平及不良妊娠结局的关系分析[J].现代生物医学进展，2019，19（20）：3944-3958，3870.
[8]	陈贤坤，吕嘉敏，陈映慧，等.妊娠期糖尿病妇女妊娠早期TPOAb 状态与甲状腺功能紊乱的关系[J].海南医学，2019，30（9）：58-61.
[9]	Saare L，Peet A，Tillmann V.Thyroid peroxidase antibodies are common in children with HLA-conferred susceptibility to type 1 diabetes，but are weakly associated with thyroid function[J].J Pediatr Endocrinol Metab，2020，33（8）：1027-1030.
[10]	刘永红，郝晋红，刘文萃，等.非妊娠期糖尿病孕妇孕前体质量指数及甲状腺功能与发生巨大儿的相关性及预测价值[J].中国计划生育学杂志，2020，28（6）：169-173.
[11]	田波，吴艳，朱晓荣，等.妊娠期糖尿病和妊娠期高血压孕妇甲状腺功能的动态观察[J].实用医院临床杂志，2020，17（3）：128-130.
[12]	Onat T，MD Caltekin，Turksoy VA，et al.The Relationship Between Heavy Metal Exposure，Trace Element Level，and Monocyte to HDL Cholesterol Ratio with Gestational Diabetes Mellitus[J].Biol Trace Elem Res，2021，199（1）：1-10.
[13]	王云杰.妊娠期糖尿病孕妇甲状腺功能异常与甲状腺自身抗体的相关性分析[J].中国卫生检验杂志，2019，29（7）：841-843.
[14]	陶彩霞.孕早期甲状腺功能与妊娠期糖尿病发病的相关性[J].中国临床医生杂志，2020，48（6）：103-106.
[15]	Lai H，Zhan ZY，Liu H.Association between thyroid hormone parameters during early pregnancy and gestational hypertension：a prospective cohort study[J].J Int Med Res，2020，48（2）:1-7.