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Quick Search     Adv Search 2021 Vol. 28, No. 15 Published: 2021-05-28   4 Mechanism of circular RNA CDR1as in mice macrophage foaming ZHANG Han；LI Xing；YANG Sha-sha；ZHAO Le；HAN Peng-fei Objective To study the expression level and mechanism of circular RNA CDR1as in mice macrophage foaming.Methods Mice macrophage(RAW264.7 cells)were cultured in vitro and divided into control group and oxidized low density lipoprotein(ox-LDL)groups with different concentrations,RAW264.7 cells were respectively induced with complete medium and ox-LDL of final concentrations were 25,50 and 100 μg/mL.The intracellular lipid profile was observed by oil red O stain,and intracellular CDR1as and miR-7a-5p expression were detected by real-time fluorescence quantitative PCR.Results Compared with control group,the intracellular lipid was increased in ox-LDL induced group,and the degree of RAW264.7 cells foaming was increased with the increase of the induced concentration,the differences were statistically significant(P＜0.05).The expression level of CDR1as decreased with the increase of ox-LDL induced concentration,the expression level of miR-7a-5p increased with the increase of ox-LDL induced concentration,the differences were statistically significant(P＜0.05).The expression levels of CDR1as and miR-7a-5p were correlated in mice macrophage foaming which induced with ox-LDL(R2=0.7879,P＜0.01).Conclusion The expression of CDR1as gradually decreases during macrophage foaming induced with ox-LDL,and the sponge miR-7a-5p might be used to regulate the behavior of macrophage-derived foam cells and affect the progression of atherosclerosis. 2021 Vol. 28 (15): 4-7 [Abstract] ( 52 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 8 Construction and preliminary evaluation of the fusion prokaryotic expression vector of M2e and Qβ JING Xin-rui；XING Ti-kun；SONG Lu-ping；YANG Zhen-ping；WANG Ya-ping；LIU wei；SONG Yan-jun；ZHANG Jing-jing Objective To construct a recombinant prokaryotic expression vector of influenza virus M2 gene(M2e)and Qβ,and to conduct immunological evaluation of Qβ-M2e virus-like particles(VLPs),to make a foundation for the development of preventive vaccines.Methods By means of molecular biology,M2e and Qβ plasmid vector were connected to construct a recombinant prokaryotic expression vector,which was identified by restriction enzyme digestion and sequencing.Then,transformed the recombinant plasmids into Escherichia coliBL21,the fusion protein Qβ-M2e was recovered and purified by density gradient centrifugation.After the animals were immunized,the proliferation of germinal center(GC)B cells was detected by immunohistochemistry and flow cytometry.Results The enzyme digestion and sequencing results were consistent with the expected.The fusion protein was observed under the electron microscope as a particle-like protein.After immunizing animals,GC B cells proliferated significantly.Conclusion The recombinant Qβ-M2e vector has been constructed successfully.And the expressed Qβ-M2e virus particles were evaluated by preliminary cytology.The vector might be able to serve as a candidate vector vaccine for influenza virus VLP vaccine,which provides information for further study of general influenza vaccine. 2021 Vol. 28 (15): 8-11 [Abstract] ( 41 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 12 Predictive value of vitamin D level on antiviral efficacy of chronic hepatitis B LI Xuan；ZHANG Li-na；WANG Song；WANG Fang；HE Qing Objective To analyze the predictive value of baseline vitamin D level on the virological response of chronic hepatitis B.Methods A total of 115 inpatients with chronic hepatitis B from October 2017 to December 2019 in the Third People′s Hospital of Shenzhen were included.According to the hepatitis B virus DNA quantitative analysis at treatment week 24,patients were divided into HBV DNA-negative group and HBV DNA-positive group.The clinical baseline characteristics of the two groups were compared.Predictive models were established using multivariate Logistic regression analyses,with the receiver operating characteristic(ROC)curve and the Hosmer-Lemeshow goodness of fit test employed as the evaluation indicators.Results Antiviral treatment for 24 weeks,71 cases(61.74%)and 44 cases(38.26%)were HBV DNA-negative and HBV DNA-positive respectively.With lower HBV DNA level and higher vitamin D level,the 24-week virological outcomes were better(P＜0.05).HBV DNA level and alanine aminotransferase were included in model 1,and HBV DNA level,HBsAg level,total bilirubin,and 25-hydroxy vitamin D were included in model 2.The areas under the ROC curve(AUC)of model 1 and model 2 were 0.735(95%CI:0.639-0.831)and 0.810(95%CI:0.732-0.890)respectively.The AUC of the two models was compared,and the difference was statistically significant(P=0.039).Conclusion The predictive model based on the baseline vitamin D level has a good predictive value for the 24-week virological response in the treatment of chronic hepatitis B. 2021 Vol. 28 (15): 12-15 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 16 Effects of Risperidone combined with repetitive transcranial magnetic stimulation on patients and serum dopamine in the treatment with schizophrenia ZHANG Xian-qiang；LYU Shuang；ZHONG Yu-long；ZHU Yan-ling Objective To explore the effects of Risperidone combined with repetitive transcranial magnetic stimulation（rTMS）on patients and serum dopamine(DA)in the treatment with schizophrenia.Methods A total of 154 patients with schizophrenia admitted to the Psychiatric Hospital of Guangzhou Civil Administration Bureau from November 2018 to August 2019 were selected as the research subjects.According to random number table method,they were divided into the research group and the control group,with 77 cases in each group.The research group was treated with Risperidone combined with low-frequency repetitive transcranial magnetic stimulation,while the control group was treated with Risperidone combined with pseudo transcranial magnetic stimulation.The overall evaluation of clinical efficacy,the positive and negative symptoms scale(PANSS),clinical global impression(CGI)and treatment emergent symptom scale(TESS),and the changes of DA concentration in peripheral blood before and after treatment were compared between the two groups.Results After treatment,the overall evaluation of clinical efficacy in the research group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The total score of PANSS after treatment in the research group was lower than that before treatment,and the difference was statistically significant(P＜0.05).After treatment,the total score of PANSS of the research group was lower than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,there were no significant differences in TESS score and DA neurotransmitter concentration in peripheral blood between the two groups(P＞0.05).Conclusion Risperidone combined with low-frequency repetitive transcranial magnetic stimulation in the treatment of schizophrenia patients has certain effect on improving the clinical symptoms of patients,and there is no significant influence on the peripheral serum DA concentration and no obvious adverse reactions.It has positive clinical application value and is worthy of clinical promotion. 2021 Vol. 28 (15): 16-19 [Abstract] ( 52 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 20 Study on toxicity of Jianweixiaoshi Tablets(only for children)in weaned rats WAN Jian-hua；ZHAN Yang；YANG Ni；HU Xu；XIAO Qiu-ping；LI Ying-meng；LIU Wen-jun Objective To observe the toxic reaction of high dose Jianweixiaoshi Tablets(only for children)to SD rats,and to provide the basis for the safe use of medicine in children.Methods A total of 60 SD rats aged 21 days were divided into the high-dose Jianweixiaoshi Tablets for children group(high-dose group)and solvent control group(control group)by alternating group according to body weight,with 30 rats in each group and half male and half female.The high-dose group was given 10 g/kg Jianweixiaoshi Tablets,and the solvent control group was given the same amount of pure water once a day for 4 weeks.After administration,40 rats were dissected and sampled,and the remaining 20 rats were dissected and sampled after 2-week recovery period.The changes of general condition,body weight,food intake,individual growth,sexual development,blood routine,blood biochemical,blood coagulation function,immune function,organ coefficient and histopathology were detected.Results After convalescence,there was no significant difference in food intake,body weight,development of bone,genitalia and immune system between the two groups(P＞0.05).The organ coefficients of liver,spleen and kidney in the high-dose group were higher than those in control group,the differences were statistically significant(P＜0.05).At the end of the administration,platelet overaccumulation and activated partial thromboplastin time of male rats in high-dose group were lower than those in control group,and triglyceride(TG),low density lipoprotein cholesterol(LDL-C)were higher than those in control group,the differences were statistically significant(P＜0.05).The erythrocyte overstock,aspartate transaminase,LDL-C and fasting blood glucose(GLU)of female rats in the high-dose group were higher than those in the control group,alanine transaminase and the percentage of lymphocytes was lower than that in the control group,the differences were statistically significant(P＜0.05).At the end of the recovery period,the number of platelets,TG and fibrinogen in male rats in the high-dose group were higher than those in control group,while the total bile acid(TBA)and fasting blood glucose in the highdose group were lower than those in control group,the differences were statistically significant(P＜0.05).The glutamyltranspeptidase and TG of female rats in high-dose group were lower than those in control group,while TBA was higher than those in control group,the differences were statistically significant(P＜0.05).At the end of the administration and the end of the recovery period,there was no statistical significance in the pathological scores of each organ between the high-dose group and the control group(P＞0.05).Conclusion After 4 weeks of intragastric administration of 10 g/kg Jianweixiaoshi Tablets(only for children)in SD rats,the blood routine,blood biochemical and coagulation function indexes of SD rats were slightly affected,but most of the indexes could be restored to normal level after the recovery period,and the pathological results of the organs did not show substantial damage.The non-toxic dose of Jianweixiaoshi Tablets(only for children)is not less than 10 g/kg,equivalent to 50 times of the clinical dose. 2021 Vol. 28 (15): 20-25 [Abstract] ( 45 ) HTML (51 KB)  PDF  (0 KB)  ( 8 ) 26 Meta-analysis of the effect of Tigeol and Capecitabine in the treatment of breast cancer ZHANG Shu-dan；LI Qi Objective To systematically evaluate the effect and safety of Tigeol and Capecitabine in the treatment of breast cancer.Methods The databases of Cochrane Library,PubMed,Embase,Wanfang,Vip,CNKI and China Biomedical Literature Database for the randomized controlled trial(RCT)of Tigeol and Capecitabine in the treatment of breast cancer until July 29,2020 were searched and traced all the references of the included literatures.Two reviewers screened and evaluated the literature according to the inclusion and exclusion criteria,and then extracted the data.The software RevMan 5.4 was used for statistical analysis.Results A total of 24 study articles were included,involving 1941 patients.The Meta-analysis showed that the clinical effect of the Tigeol group(experimental group)was better than that of the Capecitabine group(control group)(OR=1.62,95%CI:1.33-1.97,P＜0.000 01).The main adverse reactions in the two groups included leukopenia,anemia,thrombopenia,nausea and vomiting,diarrhea,abnormal liver function,oral mucoiditis,fatigue,hand and foot syndrome，myelosuppression.The incidence rates of hand-foot syndrome and nausea and vomiting in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in other adverse reactions between the two groups(P＞0.05).Conclusion The clinical effect of Tigeol in the treatment of breast cancer is better than that of Capecitabine,and the safety is better. 2021 Vol. 28 (15): 26-29 [Abstract] ( 48 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 30 Application of cognitive behavioral therapy on explosive tinnitus YANG Mei-yan；QI Li-li；LI Xu；JIA Zong-xin；ZHAO Xu-ping；WANG Bing Objective To investigate the effect of cognitive behavioral therapy(CBT)on explosive tinnitus.Methods A total of 62 patients with explosive tinnitus admitted to the Department of Otolaryngology,No.984 Hospital of the People′s Liberation Army from January 2018 to June 2019 were selected as the subjects.They were divided into control group(n=32)and combined treatment group(n=30)by coin toss method.Patients in the control group were given conventional drug treatment,and patients in the combined treatment group were given drug combined CBT treatment.The course of treatment was 1 month.The tinnitus handicap inventory(THI)and anxiety self-assessment scale(SAS)were used to estimate the tinnitus severity and negative emotions before and 1 month after treatment.The THI and SAS scores were compared between the two groups,respectively.The THI and SAS scores of patients with tinnitus and anxiety in control group(n=6)and patients with tinnitus and anxiety in combined treatment group(n=9)were further compared.Results The THI and SAS scores after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).There were no significant differences in THI and SAS scores between the two groups before and after treatment(P＞0.05).The total effective rate of combined treatment group(83.33%)was higher than that of control group(31.25%),and the difference was statistically significant(P＜0.05).After treatment,the THI and SAS scores of tinnitus patients with anxiety in the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05).After treatment,SAS and THI scores of patients with tinnitus and anxiety in the combined treatment group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion CBT can effectively improve the subjective symptoms of patients with explosive tinnitus with anxiety,reduce the impact of tinnitus on their lives and alleviate their negative emotions,which is worthy of active clinical promotion. 2021 Vol. 28 (15): 30-33转37 [Abstract] ( 46 ) HTML (39 KB)  PDF  (0 KB)  ( 6 ) 34 Expression level and clinical significance of long non-coding RNA-LY86-AS1 in glioma WANG Xi；SUN Bin；WANG Heng-lu；LI Cheng-long；QIU Jian-qing Objective To investigate the expression level of long non-coding RNA(lncRNA)-LY86-AS1 in glioma and its relationship with clinical characteristics and prognosis.Methods Glioma specimens and adjacent normal brain tissues of 67 patients with glioma who underwent surgical treatment in the Binzhou Medical University Hospital from June 2012 to December 2014 were collected.R-language gene chip analysis technology was used to identify differentially expressed lncRNA.Real-time quantitative polymerase chain reaction(qRT-PCR)was used to detect the difference of lncRNA-LY86-AS1 expression in glioma samples and normal brain tissue adjacent to glioma,and χ2-square test was used to analyze the relationship between the expression level of lncRNA-LY86-AS1 and the clinical characteristics and prognosis of glioma.Results The lncRNA-LY86-AS1 was differentially expressed in gliomas.Compared with normal brain tissue samples adjacent to the tumor,the expression of lncRNA-LY86-AS1 in glioma samples was downregulated,and it was related to glioma classification(P＜0.05).The expression level of lncRNA-LY86-AS1 showed statistical differences with WHO grading,KPS score and tumor recurrence of glioma patients(P＜0.05),while there was no statistical difference among gender,age and tumor size of patients(P＞0.05).The prognosis of glioma patients with low expression of lncRNA-LY86-AS1 was poor.Conclusion The lncRNA-LY86-AS1 expression is down-regulated in glioma tissues and is associated with poor prognosis in glioma patients.Therefore,it is speculated that lncRNA-LY86-AS1 might be a potential therapeutic target and prognostic indicator for glioma. 2021 Vol. 28 (15): 34-37 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 38 Research progress on the application of blood recovery machine in spinal surgery RAN Wei-peng；WANG Meng；QIN Zhong-tang；LI Hong-jian Massive blood loss has always been found in spinal surgery,especially in anterior decompression,multisegmental correction and posterior internal fixation.The amount of bleeding has become an important factor restricting the development of surgical techniques with complicated procedures of massive intraoperative hemorrhage.Perioperative safety of patients will be periled by the excessive intraoperative blood loss.Meanwhile,allogeneic blood transfusion also has the risk of infection,blood-transfusion complications,difficulty in blood collection,high price and so on.And allogeneic blood affects coagulation,immunity,hemodynamics,prognosis and functional recovery of patients.Recently,blood recovery technology is mainly represented by blood recovery machine,which is widely used in orthopedic spine surgery.Averting the disadvantages of allogeneic blood transfusion,the development of autologous blood recovery and transfusion technology and the use of blood recovery machine in operation can alleviate the pressure of current blood shortage,make efficient use of intraoperative clean blood,decrease blood transfusion costs,ensure the safety of blood transfusion of patients,and promote the recovery with definitely economic benefits and clinical value. 2021 Vol. 28 (15): 38-42 [Abstract] ( 47 ) HTML (49 KB)  PDF  (0 KB)  ( 7 ) 43 Research progress of psoriasis induced by Infliximab in the treatment of inflammatory bowel disease ZHOU Lian-yu；WU Jing；ZHANG Feng-rui；MIAO Ying-lei Infliximab(IFX)is a monoclonal immunoglobulin G1 antibody against tumor necrosis factor-α which has been widely used in the treatment of inflammatory bowel disease(IBD)and psoriasis in China,and the effect is remarkable.It is interesting to note that in recent years,the reports of psoriasis induced by IFX in IBD have gradually increased.Psoriasis,as the complication of IBD,aggravates the patients′suffering,and its characteristics,pathogenesis,prevention,diagnosis,treatment are urgently needed to be solved.In the treatment of IBD,the pathogenesis of psoriasis may be related to immune,genetic,IFX concentration and other factors.A review was performed to provide information about the research progress of psoriasis induced by IFX in IBD. 2021 Vol. 28 (15): 43-47转51 [Abstract] ( 65 ) HTML (52 KB)  PDF  (0 KB)  ( 6 ) 48 Progress in the treatment of recurrent high-grade glioma AN Hui-tao Glioma is a primary malignant tumor of nervous system,accounting for about 40% of all brain tumors and 80% of brain malignant tumors,and it is easy to relapse.At present,World Health Organization(WHO)divides gliomas into four grades,of which gradeⅠ-Ⅱare low-grade gliomas,including diffuse astrocytoma,pilocytic astrocytoma,etc.,while gradeⅢ-Ⅳis high-grade glioma,which has a higher degree of malignancy,such as glioblastoma,anaplastic astrocytoma,etc.Most of the high-grade gliomas will recur in a short time after treatment,and the recurrence rate is high,which will invade multiple cerebral lobes and cause brain metastasis.The short-term mortality of recurrent highgrade glioma is high.How to effectively improve the treatment effect is the focus of clinical research.In order to pay more attention to recurrent high-grade glioma and improve its therapeutic effect,a large number of literatures on clinical treatment of recurrent high-grade glioma in recent five years were reviewed.After eliminating the unreasonable data and insufficient empirical evidence,the treatment progress of recurrent high-grade glioma was summarized,so as to provide clinical reference and reference. 2021 Vol. 28 (15): 48-51 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 52 Clinical effect of microparticle humidification on airway humidification in non-mechanical tracheotomy patients WANG Feng-zhen；ZHONG Xue-mei；ZHANG Yu-hao；YE Ting；LIU Hua-zhi Objective To explore the clinical effect of microparticle humidification in airway humidification of non-mechanical tracheotomy patients.Methods From January 2018 to February 2020,66 patients with tracheotomy and non mechanical ventilation in the Department of critical care medicine of the First Affiliated Hospital of Gannan Medical College were selected as the research objects.They were divided into experimental(n=33)and control(n=33)groups using the random number table method.The microparticle humidification method was used in the experimental group,while the conventional continuous airway instillation method was used in the control patients.Sputum pH,number of suctioning attempts,blood oxygen saturation(SpO2)value,number of dislodgements of the humidified hose,time spent on a single wet device and cost of the humidification device were compared between the two groups.Results The sputum pH value of patients in the experimental group was higher than that in the control group on the 3rd,4th,5th,6th and 7th day after intervention,and the differences were statistically significant(P＜0.05).The sputum suction times of patients in the experimental group were lower than those in the control group on the 3rd,4th,5th and 7th day after intervention,and the differences were statistically significant(P＜0.05).The SpO2 value of the experimental group was significantly higher than that of the control group on the 3rd,4th,5th,6th and 7th day after intervention,and the differences were statistically significant(P＜0.001).The times of wetting hose falling off in the experimental group was less than that of control group,the nursing time of single wetting device was shorter than that of control group and the nursing cost of wetting device were lower than those in the control group,and the differences were statistically significant(P＜0.001).Conclusion The microparticle plus wet method was conducive to improving the pH and SpO2 value of sputum,reducing the number of sputum aspiration,the nursing time of a single humidification device,and the cost of the humidification device,thereby reducing the nursing workload and the hospitalization expenses of patients. 2021 Vol. 28 (15): 52-55转59 [Abstract] ( 43 ) HTML (42 KB)  PDF  (0 KB)  ( 7 ) 56 Clinical effect of Huayu Kesai Decoction in the treatment of qi deficiency and blood stasis syndrome in the recovery stage of ischemic stroke ZANG Cui-cui Objective To explore the clinical effect of Huayu Kesai Decoction in treating qi deficiency and blood stasis syndrome of ischemic stroke during convalescence.Methods From December 2017 to December 2018,60 patients admitted to the Rehabilitation Department of the Affiliated Hospital of Shandong Academy of Traditional Chinese Medicine and the Ward of the Department of Traditional Chinese Medicine of Qianfoshan Hospital in Shandong Province were selected as the research objects.They were randomly divided into the treatment group and the control group according to the digital lottery method,with 30 cases in each group.The treatment group was treated with Huayu Kesai Decoction,while the control group was treated with Naoxintong Capsules.Patients in both groups were treated for 28 days.The effective rate,traditional Chinese medicine syndrome scores of qi deficiency and blood stasis,neurological defect scoreand hemorheology indexes（high whole blood viscosity,low whole blood viscosity,plasma viscosity,platelet aggregation rate,hematocrit）and total incidence of adverse reactions in the two groups were compared.Results The effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the scores of traditional Chinese medicine syndrome of qi deficiency and blood stasis,neurological defect score in the treatment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the whole blood high shear viscosity,plasma viscosity and platelet aggregation rate in the treatment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The therapeutic effect of Huayu Kesai Decoction on the syndrome of qi deficiency and blood stasis during the convalescent period of ischemic stroke is remarkable. 2021 Vol. 28 (15): 56-59 [Abstract] ( 40 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 60 Application of balloon-type endotracheal intubation fixator in patients with oral endotracheal intubation HE Liang；WU Jie-hua；WANG Meng-meng；CAO Xue-qin；ZHANG Xiao-xue Objective To investigate the application effect of balloon-type endotracheal intubation fixator in patients with oral endotracheal intubation.Methods A total of 81 patients with oral endotracheal intubation admitted to the Second Affiliated Hospital of Nanchang University from February 2017 to May 2019 were selected as the research objects.According to the random number table method,they were divided into the control group(40 cases)and the observation group(41 cases).The control group used traditional tape to fix the catheter,and the observation group used balloon-type endotracheal intubation fixator to fix the catheter.The incidence of catheter displacement,intubation fixation time,replacement time of fixation and tape,visual analogue scale(VAS)score,and total incidence of skin complications were compared between the two groups.Results The incidence of catheter displacement in the observation group was 36.6%,which was lower than 62.5% in the control group,the difference was statistically significant(P＜0.05).The intubation fixation time and replacement time of fixation and tape in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).The VAS score of the observation group was(4.1±0.9)points,which was lower than the(6.3±1.2)points of the control group,and the difference was statistically significant(P＜0.05).The total incidence of skin complications in the observation group was 7.3%,which was lower than 27.5% in the control group,and the difference was statistically significant(P＜0.05).Conclusion The application effect of balloon-type endotracheal intubation fixator in patients with oral endotracheal intubation is significant and can be popularized in clinic. 2021 Vol. 28 (15): 60-62转66 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 63 Effect comparison of Sevoflurane and Propofol during recovery period of deep anesthesia in laparoscopic surgery under Narcotrend monitoring ZENG Liang-liang；ZHONG Bao-qiong；WANG Ri-lian Objective To investigate the effect of Sevoflurane and Propofol during the recovery period of deep anesthesia in laparoscopic surgery under Narcotrend monitoring.Methods The clinical data of 60 patients receiving general or gynecological laparoscopic surgery under Narcotrend monitoring in Liaobu Hospital of Dongguan City,Guangdong Province from January to August,2020 were retrospectively analyzed.The patients were divided into Sevoflurane group(28 cases)and Propofol group(32 cases)according to the different drugs used in deep anesthesia.Sevoflurane group was given Sevoflurane and Remifentanil to maintain anesthesia,while Propofol group was given Propofol and Remifentanil to maintain anesthesia.Hemodynamic indexes,functional recovery time,visual analogue scale(VAS)score,maximum Ricker calming agitation score and 24 h recovery quality(QOR-40)score were compared between the two groups.Results There were no statistically significant differences in the heart rate(HR)and mean arterial pressure(MAP)between the two groups before operation and during the recovery period(P＞0.05).The recovery time of spontaneous respiration,breathing and eye-opening time,extubation time,and recovery time of orientation in the Propofol group were shorter than those in the Sevoflurane group,and the differences were statistically significant(P＜0.05).VAS score and maximum Ricker sedative agitation score in the Propofol group were lower than those in the Sevoflurane group,and QOR-40 score was higher than that in the Sevoflurane group,and the differences were statistically significant(P＜0.05).Conclusion Under Narcotrend monitoring,the effect of Propofol and Sevoflurane in laparoscopic deep anesthesia is relatively stable.The recovery time in the recovery period of deep anesthesia with Propofol is shorter,the recovery quality is higher,the patients′restlessness is less,the pain level is lower,and it is more conducive to the functional recovery of patients after awakening. 2021 Vol. 28 (15): 63-66 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 67 Clinical application of Fistula protector-internal fistula puncture handover sheet ZHAO Dan-dan Objective To explore the correct use of fistula protection sign-internal fistula puncture handover sheet(hereinafter referred to as"fistula protection"),and to analyze its effect on vascular evaluation and internal fistula vascular protection of patients with arteriovenous fistula.Methods From May 2019 to may 2020,60 regular hemodialysis patients with arteriovenous fistula for the first time in the hemodialysis center of Jiangxi Pingxiang People′s Hospital were selected as the research objects.The patients were divided into control and observation groups by the random number table method,with 30 cases in each group.The control group used physical examination method for vascular access management,and the observation group used fistula protector for vascular access management.The success rate of one-time puncture,puncture execution rate,puncture complication rate,pain degree and patient satisfaction were compared between the two groups.Results The success rate of one-time puncture and the execution rate of puncture in the observation group were higher than those in the control group,and the incidence of puncture complications was lower than that in the control group,the differences were statistically significant(P＜0.05).The number of mild pain cases in the observation group was more than that in the control group,and the number of moderate pain cases and severe pain cases in the observation group was less than that in the control group,the differences were statistically significant(P＜0.05).The total satisfaction degree of nursing care in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The correct use of the internal fistula puncture handover sheet can reduce the degree of pain and the probability of complications,improve the success rate of puncture and patient satisfaction,and is worthy of use in related clinics. 2021 Vol. 28 (15): 67-69 [Abstract] ( 42 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 70 Clinical study on myocardial damage caused by acute CO poisoning and early intervention and prognosis LIAO Yong；AI Qing-ya；LIAO Yu；LIU Fei；ZHONG Xue-fei；XIA Hou-zong Objective To investigate the clinical effect of acute carbon monoxide(CO)poisoning on myocardial damage and early intervention and prognosis.Methods Clinical data of 90 patients with myocardial damage caused by acute CO poisoning admitted to People′s Hospital of Xinyu City,Jiangxi Province from June 2017 to June 2020 were retrospectively analyzed and divided into intervention group and control group according to different treatment methods,with 45 cases in each group.Patients of both groups received conventional symptomatic and supportive treatment.On this basis,the intervention group received early hyperbaric oxygen therapy,and the control group received late hyperbaric oxygen therapy.Both groups received continuous treatment for 14 days.The clinical efficacy,clinical indicators,cardiac troponin T(cTnT)and myocardial enzyme spectrum were compared between the two groups.Results The total effective rate of treatment in the intervention group was higher than that in the control group,the recovery time and hospitalization time were shorter than those in the control group,hyperbaric oxygen chamber treatment times was less than that of the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of cTnT,creatine kinase(CK),aspartate aminotransferase(AST),lactate dehydrogenase(LDH)and creatine kinase isoenzyme(CKMB)in the groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the levels of cTnT,CK,AST,LDH and CK-MB in the intervention group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Early hyperbaric oxygen treatment of patients with myocardial damage caused by acute CO poisoning can effectively improve the patient′s condition,improve cTnT and myocardial enzyme spectrum indicators,reduce the number of hyperbaric oxygen treatments,and shorten the recovery time and hospitalization time.It is worthy of clinical promotion. 2021 Vol. 28 (15): 70-72转76 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 73 Clinical effect of Yangxinshi Tablets combined with Sacubitril Valsartan Sodium in the treatment of chronic heart failure in elderly patients TANG Ai；YANG Gui-zhi Objective To investigate the clinical effect of Yangxinshi Tablets combined with Sacubitril Valsartan Sodium(ARNI)in the treatment of elderly patients with chronic heart failure.Methods A total of 120 elderly patients with CHF admitted to Ji′nan Hospital of Integrated Traditional Chinese and Western Medicine from June 2018 to December 2019 were selected as the research objects and divided into treatment group(60 cases)and control group(60 cases)according to random number table method.The control group was treated with standard treatment,and the treatment group was treated with Yangxinshi Tablets combined with ARNI on the basis of the control group.The total effective rate,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment group was higher than that of control group,the difference was statistically significant(P＜0.05).After treatment,LVEF of the two groups were higher than before treatment,while LVEDD were lower than before treatment,and LVEF of the treatment group was higher than that of the control group,LVEDD of the treatment group was lower than that of the control group,the differences were statistically significant(P＜0.05).There were no obvious adverse reactions such as hypotension during treatment in two groups.Conclusion Yangxinshi Tablets combined with ARNI can significantly improve the clinical symptoms of elderly patients with CHF,improve cardiac ultrasound index,reverse ventricular remodeling,and have good safety. 2021 Vol. 28 (15): 73-76 [Abstract] ( 61 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 77 Effect of MTH1 inhibitor TH588 on the proliferation and migration of human malignant melanoma A375 cells HUO Ji-wu；LI Guang-zao；LI Lu；XIONG Zhu-you；LI Wei Objective To investigate the effect of MTH1 inhibitor TH588 on the proliferation and migration of human malignant melanoma A375 cells.Methods Cell culture method was used to culture human malignant melanoma A375 cells,the inverted microscope method was used to observe the influence of TH588 on cell morphology,and the CCK-8 method was used to detect the inhibitory effect of different concentrations of TH588(0,4,8,16,32,64 μmol/L)on the proliferation of A375 cells.The colony cloning inhibition test was used to observe and compare the proliferation inhibition effect of TH588 on A375 cells at three concentrations(12.8,6.4 and 3.2 μmol/L),cell scratch experiment was used to detect the effect of TH588 on the migration ability of A375 cells.Results The CCK-8 test results showed that the cell survival rate of the TH588 groups with different concentrations at the same time period was lower than that of the blank control group.The cell survival rate at the concentration of 32 and 64 μmol/L TH588 at 48 and 72 h was lower than that at 24 h.The results of the inverted microscope method showed that after TH588 acted on human malignant melanoma A375 cells,the cells shrank significantly,the edges became blurred,and debris particles were produced.Colony cloning inhibition test showed that TH588 had a significant inhibitory effect on the proliferation of human malignant melanoma A375 cells.The cell scratch experiment showed that the scratch migration distance of A375 cells after TH588 was shorter than that of A375 cells without intervention within 48 h.Conclusion TH588 has a significant inhibitory effect on the proliferation and migration of human malignant melanoma A375 cells,and low concentration TH588 has a better inhibitory effect. 2021 Vol. 28 (15): 77-80 [Abstract] ( 41 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 81 Clinical effect of hyperbaric oxygen in the treatment of delayed encephalopathy after carbon monoxide poisoning ZHANG Xiu-jin Objective To investigate the clinical effect of hyperbaric oxygen in the treatment of delayed encephalopathy after carbon monoxide poisoning(DEACMP).Methods A total of 68 DEACMP patients who were treated in Affiliated Hospital of Chifeng University from June 2018 to June 2020 were selected as the research objects.The patients were divided into the control group and the experimental group using the stratified sampling method,with 34 cases in each group.The control group only received routine medical treatment,while the experimental group was treated with hyperbaric oxygen on this basis.The clinical treatment effect was compared between the two groups.Results Before treatment,there were no significant differences in the scores of the ability of daily living(ADL),mini-mental state examimation(MMSE)and Montreal cognitive assessment scale(MoCA)between the two groups(P＞0.05)After treatment,the ADL score of the experimental group was lower than that of the control group,and the MMSE and MoCA scores were higher than those of the control group,with statistically significant differences(P＜0.05).The total effective rate of treatment in the experimental group(91.18%)was higher than that in the control group(79.41%),and the difference was statistically significant(P＜0.05).In terms of serum indicators,the levels of central nervous system specific protein(S100β)and neuron specific enolase(NSE)before treatment between the two groups were not statistically different(P＞0.05).After treatment,the serum S100β and NSE levels of the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).The serum S100β and NSE levels of the experimental group after treatment were lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion The combined use of hyperbaric oxygen therapy on the basis of conventional Western medicine treatment can effectively correct the symptoms of brain hypoxia,improve the patients′cognitive function,improve the ability of daily living,and then exert a significant therapeutic effect.It is worthy of promotion and implementation. 2021 Vol. 28 (15): 81-84 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 5 ) 85 Effect of different Capecitabine administration regimens in the treatment of advanced gastrointestinal tumors XIA Wei；LAN Chun-hui；LI Qing XIAO；Qian-song；CHEN Dong-feng Objective To investigate the therapeutic effect of Capecitabine in patients with advanced digestive tract tumor.Methods A total of 100 patients with advanced digestive tract tumor admitted to Department of Gastroenterology,Special Medical Center of PLA Military Medical University from January 2017 to March 2019 were selected as the research subjects,and they were divided into experimental group(50 cases)and control group(50 cases)according to random number table method.The control group was treated with 2500 mg/m2 Capecitabine,and the experimental group was treated with 2000 mg/m2 Capecitabine.The treatment effect and the incidence of adverse reaction were compared between the two groups.Results The total effective rate of experimental group was 80.00%,which was higher than that of control group(62.00%),the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the test group was 22.00%,which was lower than 48.00% in the control group,the difference was statistically significant(P＜0.05).Conclusion Compared with 2500 mg/m2 Capecitabine treatment,patients with advanced gastrointestinal cancer receiving 2000 mg/m2 Capecitabine treatment can improve the treatment effect and reduce the incidence of adverse reactions,which is safe and effective. 2021 Vol. 28 (15): 85-87 [Abstract] ( 52 ) HTML (29 KB)  PDF  (0 KB)  ( 6 ) 88 Clinical effect of intervertebral bone graft fusion and internal fixation under foraminal endoscope in the treatment of lumbar spondylolisthesis HU Bo；LI Si-yun；LU Wen-jie；HE Liang；LUO Yuan-yi Objective To explore the clinical effect of intervertebral foraminal bone graft fusion and internal fixation in the treatment of lumbar spondylolisthesis.Methods From July 2019 to June 2020,60 patients with lumbar spondylolisthesis admitted to Jiangxi Hospital of Integrated Traditional Chinese and Western Medicine were selected as the research objects.They were divided into the study group and the control group by grasping the balls,with 30 cases in each group.Patients in the study group were treated with foraminal bone graft fusion and internal fixation,and in the control group,traditional open surgery was adopted.The total effective rate,operation-related indexes,total incidence of postoperative complications,reduction rate of spondylolisthesis and interbody fusion rate were compared between the two groups.Results The total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The operation time of the study group was shorter than that of the control group,and the intraoperative blood loss in the study group was less than that of the control group,and the differences were statistically significant(P＜0.05).The total incidence of postoperative complications in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The reduction rate of spondylolisthesis and the rate of intervertebral fusion in the study group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Compared with the traditional open surgical treatment,for patients with lumbar spondylolisthesis,intervertebral foraminal bone graft fusion and internal fixation has an ideal clinical effect on reducing the incidence of complications,and increasing reduction of spondylolisthesis and rate of intervertebral fusion,which is worthy of clinical promotion. 2021 Vol. 28 (15): 88-90转94 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 91 Influence of active functional exercise on the degree of inflammation after total knee arthroplasty CHEN De-xin；ZHU Jin-ming；CHEN Yong-hua；LU Hui；ZHAO Ru-ping Objective To investigate the effect of active functional exercise at different times after total knee arthroplasty on the degree of inflammation.Methods From January 2017 to January 2020,a total of 92 cases of patients undergoing total knee replacement in Zhaoqing City Gaoyao District Hospital of Traditional Chinese Medicine were selected as the research objects,they were divided into research group(46 cases)and control group(46 cases)according to the random number table method.The control group adopted the method of active functional exercise within 3 days after the operation,and the research group adopted the method of active functional exercise on the same day after the operation.The levels of tumor necrosis factor(TNF)-α,interleukin(IL)-lβ,IL-6,limb mobility and limb swelling were compared between the two groups.Results Before intervention,there were no statistically significant differences at the levels of TNF-α,IL-lβ and IL-6 between the two groups(P＞0.05);there were no statistically significant differences between the two groups in the mobility and swelling degree of the affected limb before operation(P＞0.05);there was no statistically significant difference between the two groups in the degree of limb swelling 14 days after surgery(P＞0.05);after intervention,the levels of TNF-α,IL-1β and IL-6 in the control group were lower than those in the control group,with significant differences(P＜0.05);the range of motion of affected limbs in the control group were higher than those in the control group at 3,7 and 14 days after surgery(P＜0.05);the swelling degree of the affected limb in the control group was lower than that in the control group at 3,7 and 14 days after surgery,and the differences were statistically significant(P＜0.05).Conclusion After total knee arthroplasty finishes anesthesia and wakes up,active functional exercise is helpful to improve the degree of inflammation,effectively improve the knee joint mobility of patients,and promote the recovery of joint function.It is worthy of further application in clinical practice. 2021 Vol. 28 (15): 91-94 [Abstract] ( 48 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 95 Application effect of the concept of rapid rehabilitation surgery in the perioperative period of knee arthroscopy ZENG Xiao-wa；RUAN Ya-qing；CHEN Jie-wen Objective To explore the application effect of the concept of rapid rehabilitation surgery in the perioperative period of knee arthroscopy.Methods The clinical data of 200 patients who underwent knee arthroscopy in Yangjiang Hospital of Traditional Chinese Medicine from June 2019 to July 2020 were retrospectively analyzed.The concept of rapid rehabilitation surgery was applied in the perioperative period.The Western Ontario and McMaster Universities osteoarthritis index(WOMAC)was used to evaluate the knee joint symptoms,severity and influence on daily life behaviors before and one month after the intervention.The Lysholm knee joint function score scale(hereinafter referred to as"Lysholm score")was used to evaluate the knee joint function before the intervention and one month after the intervention,and the excellent and good rate of knee function was calculated,postoperative complications were recorded.Results At one month after the intervention,the WOMAC score of the patients was lower than that before the intervention,the difference was statistically significant(P＜0.05).At one month after the intervention,the Lysholm score of the patients was higher than that before the intervention,the difference was statistically significant(P＜0.05),and the excellent and good rate of knee joint function was 90.00%.There were 5 cases of nausea,2 cases of infection,3 cases of joint effusion and 2 cases of joint effusion in 200 patients,and the total incidence of complications was 6.00%.Conclusion The application of the concept of rapid rehabilitation surgery in the perioperative period of knee arthroscopy can improve the symptoms,severity of knee joint and influence on daily life behaviors,and improve the postoperative knee joint function with fewer complications,so it is worthy of application and promotion. 2021 Vol. 28 (15): 95-97 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 98 Clinical effect of arthroscopic debridement combined with traditional Chinese medicine fumigation and washing in treatment of early and middle stage knee osteoarthritis XU Guan-wei；XIANG Wen-dong；GE Rui Objective To explore the clinical effect of arthroscopic debridement combined with traditional Chinese medicine fumigation and washing in the treatment of early and middle stage knee osteoarthritis.Methods A total of 68 patients with early and mid-stage knee osteoarthritis treated in Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine from March 2018 to May 2020 were selected as the research subjects,and they were divided into experimental group(34 cases)and the reference group(34 cases)by dice rolling.The experimental group were treated with arthroscopic debridement combined with traditional Chinese medicine fumigation and washing,while the control group were treated with arthroscopic debridement.The treatment effect,knee-related function score and pain perception score before and at one month after treatment,and treatment satisfaction were compared between the two groups.Results The improvement and cure rate of the experimental group was higher than that of the control group,the difference was statistically significant(P＜0.05).The knee-related function score of the experimental group at one month after treatment was higher than that of the control group,the difference was statistically significant(P＜0.05).The pain perception score of the experimental group at one month after treatment was lower than that of the control group,the difference was statistically significant(P＜0.05).The treatment satisfaction of the experimental group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion Arthroscopic debridement combined with traditional Chinese medicine fumigation and washing shows good results in the treatment of early and middle stage knee osteoarthritis,which can improve the knee joint function,reduce pain and increase satisfaction. 2021 Vol. 28 (15): 98-100转104 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 101 Effect of autologous platelet-rich plasma on pain degree and joint function in patients with knee osteoarthritis LIU Hui-wen；SHI Xiao-hua；DENG Hao；FU Yu-qi；YUAN Zhi-feng Objective To investigate the effects of autologous platelet-rich plasma(PRP)on pain and joint function in patients with knee osteoarthritis.Methods A total of 120 patients with knee osteoarthritis admitted to Jingdezhen NO.1 People′s Hospital from March 2017 to March 2019 were selected as the research objects,they were randomly divided into two groups according to double-blind method,each with 60 cases.The control group was treated with chondroitin sulfate tablets,and the observation group was treated with autologous PRP technology on the basis of the control group,all treatment for 5 weeks.The pain visual analog scale(VAS)was used to assess the degree of knee joint pain,and the knee joint and osteoarthritis score(KOOS)was used to assess the joint function.The knee joint pain degree,joint function and occurrence of adverse reactions were compared between the two groups.Results After 5 weeks of treatment,the VAS scores of both groups were lower than those before treatment,and the VAS score of the observation group was lower than that in the control group,with statistical significant differences(P＜0.05);after 5 weeks of treatment,the KOOS scores of both groups were lower than those before treatment,and the KOOS score of the observation group was lower than that in the control group,with statistical significant differences(P＜0.05);during treatment,compared the total incidence rate of adverse reaction of both groups,the difference was not significant statistically(P＞0.05).Conclusion Autologous PRP treatment for patients with knee osteoarthritis can effectively reduce knee pain,improve joint function,keep the safety of medication. 2021 Vol. 28 (15): 101-104 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 105 The effect of shoulder arthroscopy on sports skeletal typeⅠandⅡBankart injuries WANG Yu Objective To explore the curative effect of shoulder arthroscopy on sports skeletal typeⅠandⅡBankart injuries.Methods A total of patients with sports skeletal typeⅠandⅡBankart injuries admitted to Changchun Orthopedic Hospital from May 2019 to July 2020 were selected as the research objects.All patients were reduced under shoulder arthroscopy and metal suture anchors were used at the same time,accepted nail fixation treatment,accepted postoperative rehabilitation exercise,the Rowes score and the University of California Shoulder System(UCLA)score were evaluated before and after surgery,and the patient′s shoulder joint activity before and after surgery were compared with Constant-Murley score,American Society of Shoulder and Elbow Surgery(ASES)score and other indicators.Results After treatment,Rowes score and UCLA score were both higher than before treatment,the differences were statistically significant(P＜0.05);there were no significant difference in the angles of shoulder flexion and elevation,lateral external rotation and internal rotation before and after treatment(P＞0.05),the Constant-Murley score and ASES score after treatment were higher than those before treatment,and the differences were statistically significant(P＜0.05).Conclusion Shoulder arthroscopy with wire anchoring technology has a good effect on the treatment of sports skeletal type I and II Bankart injuries.The postoperative healing speed is fast and the trauma is small.It is worthy of in-depth clinical investigation. 2021 Vol. 28 (15): 105-107转111 [Abstract] ( 43 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 108 Improvement effect of hand function in patients with open metacarpal and phalangeal fractures treated with mini plate internal fixation ZHAN Yi-bing；LI Hua；JIN Zhao-guo；XIONG Huai-feng Objective To analyze the improvement effect of hand function in patients with open metacarpal and phalangeal fractures treated with mini plate internal fixation.Methods A total of 54 patients with open metacarpal and phalangeal fractures treated in the Third People′s Hospital of Jingzhou City in Hubei Province from January 2018 to August 2020 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 27 cases in each group.Patients in the control group were treated with conventional surgery,and patients in the observation group were treated with microplate internal fixation.The total incidence of complications,operation time,healing time,hospital stay,recovery time and hand function recovery were compared between the two groups.Results The total incidence of complications in observation group was lower than that in control group,and the difference was statistically significant(P＜0.05).The fracture healing time,hospitalization time and recovery time in the observation group were shorter than those in the control group,and the operation time was longer than that in the control group,and the differences were statistically significant(P＜0.05).The excellent and good rate of hand function in observation group was higher than that in control group after treatment,and the difference was statistically significant(P＜0.05).Conclusion Miniature plate internal fixation is a common method for the treatment of open metacarpal and phalangeal fractures.It has obvious therapeutic advantages,speeds up the postoperative recovery of patients and reduces the occurrence of complications.It is worthy of clinical application. 2021 Vol. 28 (15): 108-111 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 112 Expression and significance of LAIR-1 in lymphocytes of patients with cervical cancer SUN Yan Objective To investigate the expression and significance of leukocyte-associated immunoglobulin-like receptor 1(LAIR-1)in lymphocytes of patients with cervical cancer.Methods From January 2019 to November 2020,30 patients with cervical cancer in the Department of Gynecology,the Third People′s Hospital of Jiujiang City were included in the cervical cancer group,and 30 volunteers who received physical examinations during the same period were included in the healthy group.The blood of patients in the cervical cancer group was collected before treatment and surgery.The cervical cancer group was divided into two subgroups according to the random number table method:15 cases in the stimulation group and 15 cases in the non-stimulation group.Each group had 3 multiple holes,and the following reagents were added respectively:transforming growth factor-β+polyhydroxyalkanoates(PHA);no PHA,transforming growth factor-β.The Ficoll density gradient centrifugation method was used to separate peripheral blood mononuclear cells(PBMC),the lymphocytes were circled in the FSC-SSC scatter diagram,and the expression levels of LAIR-1 were analyzed in the T cell subsets of CD4+,CD8+and natural killer(NK)cells.Results The expression levels of LAIR-1 molecules of CD4+,CD8+T cells and NK cells in the cervical cancer group were higher than those in the healthy group,and the differences were statistically significant(P＜0.05).The expression levels of LAIR-1 in CD4+,CD8+and NK cells in the stimulation group were lower than those in the non-stimulation group,and the differences were statistically significant(P＜0.05).Conclusion LAIR-1 may participate in the mechanism of inhibiting the killing activity of NK cells and CTL cells,and inhibit the body′s anti-tumor immune response. 2021 Vol. 28 (15): 112-114转119 [Abstract] ( 46 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 115 Clinical effect of single-port laparoscopic breast-conserving surgery on patients with early breast cancer HUANG Hai-rong；GAO Hong-xia；ZHAO Ting-ting；YU Hai-yang Objective To investigate the clinical effect of single-port laparoscopic breast-conserving surgery on patients with early breast cancer.Methods A total of 86 patients with early breast cancer admitted to the Department of Breast Surgery,Liangxiang Hospital in Fangshan District,Beijing from November 2017 to November 2019 were selected as the research objects.According to the random number table method,they were divided into observation group and control group,with 43 cases in each group.The observation group was treated by single-port laparoscopic breast-conserving surgery,and the control group was treated by open breast-conserving surgery.The perioperative indexes,common postoperative complications and breast appearance satisfaction were compared between the two groups.Results Breast conserving surgery was successfully completed in 86 patients with a success rate of 100.00%.The operation time of observation group was longer than that in the control group,the amount of intraoperative blood loss was less than that in the control group,and the total length of incision was shorter than that in the control group,and the differences were statistically significant(P＜0.05).There were no statistical significances in the total amount of postoperative drainage,drainage time and hospital stay between the two groups(P＞0.05).The total incidence of postoperative complications in observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The breast appearance satisfaction of observation group was higher than that of control group,and the difference was statistically significant(P＜0.05).Conclusion Compared with open breast-conserving surgery,the single-port laparoscopic breast-conserving surgery has such advantages as smaller wound,less complications,and better cosmetic outcomes in treating patients with early breast cancer. 2021 Vol. 28 (15): 115-119 [Abstract] ( 40 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 120 Diagnostic value of narrow-band imaging endoscopy in screening early gastrointestinal cancer and precancerous lesions of digestive tract LIN Zhen-wei；CHEN Dong-yun；DU Rong-guo；GUAN Jia-xi Objective To explore the diagnostic value of narrow-band imaging endoscopy in screening early gastrointestinal cancer and precancerous lesions of the digestive tract.Methods A total of 100 patients admitted to Yangjiang People′s Hospital from August 2018 to May 2020 who were confirmed with helicobacter pylori related tests,gastric function tests,and stool occult blood tests were selected as the research objects.The patients were divided into observation group and control group by simple randomization,with 50 cases in each group.Observation group received endoscopic diagnosis screening with narrow-band imaging endoscopy;the control group was diagnosed by traditional endoscopic observation.The detection rates of early gastrointestinal cancer and precancerous lesions in the digestive tract and the types of cancers were compared between the two groups.The lesion contour score,microvascular morphological score and gastric pit morphological score of examine imaging were compared between the two groups.Results The detection rate of early gastrointestinal cancer and precancerous lesions of digestive tract in observation group(98.0%)was higher than that in control group(78.0%),and the difference was statistically significant(P＜0.05).There was statistically significant difference between the two groups in the results of cancer type examination(P＜0.05).The lesion contour score,microvascular morphological score and gastric pit morphological score of examine imaging in observation group were higher than those in control group,the differences were statistically significant(P＜0.05).Conclusion In the screening and diagnosis of early gastrointestinal cancer and precancerous lesions,narrowband imaging endoscopy has a high detection rate,and can accurately describe the type of cancer in patients.The imaging quality is also high,and the lesion tissue can be accurately observed,which is of high clinical promotion value. 2021 Vol. 28 (15): 120-122转129 [Abstract] ( 37 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 123 Analysis of influencing factors of poor prognosis of hysteroscopy in the treatment of patients with uterine scar diverticulum MEI Jin-feng；FAN He-hua；YANG Li-juan Objective To explore the influencing factors of poor prognosis of hysteroscopy in the treatment of patients with uterine scar diverticulum.Methods A total of 80 patients with uterine scar diverticulum who underwent hysteroscopic repair in Nanchang Institute of Medical Sciences from January 2018 to January 2020 were selected.The poor prognosis of patients were counted,the baseline of patients′datas were collected,the factors that may lead to poor prognosis of uterine scar diverticulum were analyzed.Results Six months after operation,65 patients had good prognosis,accounting for 81.25%,and 15 patients had poor prognosis,accounting for 18.75%.Univariate analysis showed that age,duration of menstruation,diverticulum width and myometrium thickness of adjacent uterus were compared between patients with good prognosis and those with poor prognosis,the differences were not statistically significant(P＞0.05);the uterine position,diverticulum depth,residual myometrium thickness,cesarean section times,postoperative infection,the time from the last cesarean section to operation were compared between the patients with good prognosis and those with poor prognosis,the differences were statistically significant(P＜0.05).The results of multi factors analysis found that eeper depth of the diverticulum,thinner thickness of the residual muscle layer,retroposition of uterus,postoperative infection were risk factors that affected the poor prognosis of the uterine scar diverticulum treated by hysteroscopy(OR＞1,P＜0.05).Conclusion Deeper depth of the diverticulum,thinner thickness of the residual muscle layer,retroposition of uterus,postoperative infection are the factors that affect the poor prognosis of uterine scar diverticulum treated by hysteroscopy. 2021 Vol. 28 (15): 123-125转135 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 126 Effect of pelvic floor neuromuscular electrical stimulation treatment of maternal with diastasis recti abdominis after parturition LIU Wen-jing；LIANG Yu-tian Objective To explore the effect of pelvic floor neuromuscular electrical stimulation treatment of maternal with diastasis recti abdominis after parturition.Methods A total of 94 maternal with diastasis recti abdominis after parturition in Panyu District Sixth People′s Hospital of Guangzhou from August 2018 to August 2020 were selected as the research object and divided into the control group and the observation group according to random number table method,with 47cases in each group.The control group received conventional rehabilitation treatment,and the observation group received pelvic floor neuromuscular electrical stimulation basis on the control group.The condition of diastasis recti abdominis,pain(visual analogue scale[VAS])score and abdominal circumference recovery were compared between the two groups before and after 10 days of intervention,and the compliance of maternal treatment was investigated.Results There were no significant differences in the distance of diastasis recti abdominis,VAS score and abdominal circumference recovery between the two groups before intervention(P＞0.05).After the intervention,the distance of diastasis recti abdominis of the observation group was smaller than that of the control group,the VAS score of the observation group was lower than that of the control group,the differences were statistically significant(P＜0.05).After intervention,the upper umbilical circumference,umbilical circumference and Infraumbilical circumference of the observation group were shorter than those of the control group,the differences were statistically significant(P＜0.05).The treatment compliance of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion Pelvic floor neuromuscular electrical stimulation could be shorten the distance of diastasis recti abdominis,reduce the pain of parturient,improve the treatment compliance,and restore the abdominal circumference to normal. 2021 Vol. 28 (15): 126-129 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 130 Comparison of the application effect of postpartum rehabilitation instrument alone or combined with manual massage in primiparae undergoing cesarean section LI Zhi-ping；ZHANG Ying-zi；LI Hui-jiao；XIE Li-jing；ZHOU Jian Objective To compare and analyze the application effect of using postpartum rehabilitation instrument alone or combined with manual massage in primiparae undergoing cesarean section.Methods From June 2019 to August 2020,126 cases of cesarean section primiparae from Fuzhou Maternal and Child Health Hospital(the Second People′s Hospital of Fuzhou)were selected and divided into a study group(n=63)and a control group(n=63)according to the random number table method.Patients in the control group received postpartum rehabilitation equipment treatment alone,and in the study group,postpartum rehabilitation equipment combined with manual massage was adopted.The lactation initiation time,breastfeeding rate,feeding status,breast tenderness,breast stiffness,and postpartum uterine fundus height changes were compared between the two groups.Results The lactation initiation time of the study group was shorter than that of the control group.The lactation volume at 48 and 72 h postpartum in both groups was more than that at 24 h postpartum.The lactation volume at 24,48,and 72 h in the study group was more than that in the control group,the differences were statistically significant(P＜0.05).The breastfeeding rate of the study group was 96.83%(61/63),which was higher than 82.54%(52/63)of the control group,the differences were statistically significant(P＜0.05).The degree of breast tenderness and breast stiffness in the study group were better than those in the control group,the differences were statistically significant(P＜0.05).The height of the uterine fundus at 48 and 72 h postpartum in the two groups was lower than that at 24 h postpartum,and the height of the uterine fundus at 24,48,and 72 h postpartum in the study group was lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Compared with the postpartum rehabilitation instrument alone,the postpartum rehabilitation instrument combined with manual massage for primiparae undergoing cesarean section can shorten the time of lactation initiation,enhance lactation,increase breastfeeding rate,reduce breast tenderness and hardness,and improve postpartum uterine fundus height. 2021 Vol. 28 (15): 130-132 [Abstract] ( 39 ) HTML (31 KB)  PDF  (0 KB)  ( 4 ) 133 Clinical application of free body position delivery combined with labor analgesia in natural delivery QU Zi-ying Objective To explore the clinical application of free body position delivery combined with labor analgesia in natural delivery(vaginal delivery).Methods A total of 100 parturients who gave birth naturally in Zhongyi Northeast International Hospita from July 2018 to December 2019 were selected as the research objects and divided into the control group and the experimental group according to random number table method,with 50 cases in each group.The control group was given routine midwifery,and the experimental group was given free body position delivery combined with labor analgesia.The delivery outcomes,stages of labor and pain situation were compared between the two groups.Results The incidences of postpartum hemorrhage,placental abruption,fetal distress in uterus and asphyxia neonatorum of the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The first,second and total stage of labor of the experimental group were shorter than those of the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference of the third stage of labor between the two groups(P＞0.05).The numerical rating scale(NRS)scores of the experimental group at 6,12 and 24 hours after delivery were lower than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Free body position delivery combined with labor analgesia could shorten the stages of labor,relieve the pain of patients and improve the delivery outcome,which is worthy of recommendation. 2021 Vol. 28 (15): 133-135 [Abstract] ( 42 ) HTML (29 KB)  PDF  (0 KB)  ( 8 ) 136 Effect of hysteroscopic polypectomy on endometrial polyps YU Hua Objective To analyze the effect of hysteroscopic polypectomy in the treatment of endometrial polyps.Methods A total of 86 patients with endometrial polyps in Dalian Jinpu New District Maternal and Child Health Hospita of from December 2018 to June 2020 were selected as the research objects.They were divided into control group(43 cases)and observation group(43 cases)by random number table method.The control group were treated with curettage under hysteroscopy,while the observation group were treated with hysteroscopic polypectomy.The overall incidence of complications,pregnancy rate,recurrence rate,operation index,endometrial thickness,menstrual volume and hemoglobin volume were compared between the two groups.Results The overall incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05);the pregnancy rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05);the recurrence rate of the observation group was lower than that of the control group,the difference was statistically significant(P＜0.05);the operation time,antibiotic use time and hospitalization time of the observation group were shorter than those of the control group,the differences were statistically significant(P＜0.05);the amount of intraoperative blood loss in the observation group was less than the control group,the difference was statistically significant(P＜0.05);the endometrial thickness of the observation group was less than that of the control group,the menstrual volume of the observation group was less than the control group,and the hemoglobin volume of the observation group was higher than the control group,the differences were statistically significant(P＜0.05).Conclusion Hysteroscopic polypectomy for patients with endometrial polyps can effectively improve the endometrial thickness and menstrual condition of patients,improve the pregnancy rate of patients,and the complications of this surgical treatment are less,which is worthy of clinical application. 2021 Vol. 28 (15): 136-138 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 139 Influence of saliva contamination on microleakage of pit and fissure sealant LIN Shan；ZHAO Xiang-yang；WANG Xiao-yan；GUO Ai-fang Objective To explore the influence of saliva contamination on microleakage of pit and fissure sealant.Methods A total of 122 premolars extracted to orthodontic need from January 2018 to April 2020 in Guangdong Yanling Hospital were selected as subjects.They were divided into group A and group B according to the random number table method,with 61 teeth in each group.There was no saliva contamination in group A and saliva contamination in group B,and both groups had their socket sulci treated using an enamel forming procedure.Microleakage was compared between the two groups.Results The microleakage score of group A was mostly 0 points,followed by 1 point.In group B,the microleakage score was mostly 3 points,followed by 2 points,1 point,and no 0 points.The microleakage score in group B was(13.74±To 1.15)points,which was higher than that of group A(1.11±0.08)points,and the difference was statistically significant(P＜0.05).Conclusion Saliva contamination can increase the microleakage of the pit and fissure sealant.It is necessary to strengthen the cleanliness of the tooth surface before clinical treatment to reduce the occurrence of microleakage of the pit and fissure sealant. 2021 Vol. 28 (15): 139-141 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 142 Comparison of application effect of different restoration methods in patients after root canal therapy HU Kang Objective To explore the application effect of different restoration methods in patients after root canal therapy.Methods A total of 60 patients who underwent root canal therapy in the Department of Stomatology of Ji′an Central People′s Hospital from April 2018 to December 2019 were selected as the research objects,they were randomly divided into group A(20 cases,20 teeth),group B(20 cases,20 teeth)and group C(20 cases,20 teeth)according to random number table method.Group A was treated with resin direct filling repair,group B was treated with resin inlay indirect repair,and group C was treated with resin direct filling repair+biosplint retention fiber crown protection.The failure load value and clinical efficacy of the three groups were compared.Results There was no significant difference in the failure load value between group B and group C(P＞0.05).The ailure load value of group B and group C were lower than those of group A,the differences were statistically significant(P＜0.05).The success rate of repair in group C were higher than those in group A and group B,the differences were statistically significant(P＜0.05).There was no significant difference in the success rate of repair between group A and group B(P＞0.05).Conclusion After root canal therapy,the application of resin direct filling and biosplint retention fiber crown protection can improve the overall repair success rate,reduce the failure load value,and has strong tooth fracture resistance,which is worthy of further promotion and application. 2021 Vol. 28 (15): 142-144 [Abstract] ( 47 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 145 Comparison of the application effect of physiological anchorage control technique and straight wire arch technique in the treatment of children with orthodontic correction CHEN Xue；SA Ri-na Objective To compare the application effect of physiological anchorage control technique and straight wire arch technique in children′s orthodontic correction.Methods From January 2016 to January 2020,66 children who underwent orthodontic correction from the Hulunbuir People′s Hospital were selected as the research subjects.They were divided into the control group(n=33,36 affected teeth)and the study group(n=33,37 affected teeth)using a random number table methods.The children in the control group were treated with traditional straight wire arch technique,and the children in the study group were treated with physiological anchorage technique.The X-ray measurement related parameters,bite force,masticatory efficiency and the incidence of complications of the two groups were compared.Results The angle between the mandibular central incisor and the mandibular plane(L1-MP),the vertical distance from the highest point of the mesial cheek tip of the mandibular first molar to the mandibular plane(L6-MP),anterior inferior height(ANS-Me),Y axis angle,the vertical distance from the highest point of the mesial cheek tip of the maxillary first molar to the palatal plane(U6-PP),the vertical distance of the incisal edge of the maxillary central incisor to the palatal plane(U1-PP)and the ratio of the antero-inferior height to the overall height(ANS-Me/N-Me)in the study group were significantly smaller than those in the control group,and the antero-superior height(N-ANS)in the study group was significantly larger than the control group,with statistical differences(P＜0.05).The bite force and chewing efficiency of the study group were significantly better than those of the control group,with statistical differences(P＜0.05).The total incidence of complications in the study group was significantly lower than that in the control group,with statistically significance(P＜0.05).Conclusion The use effect of physiological anchorage control technique in orthodontic correction of children is better than straight wire arch technique in the vertical control of maxillary incisors.It can improve the masticatory function of children and is worthy of popularization and application. 2021 Vol. 28 (15): 145-147转158 [Abstract] ( 27 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 148 Clinical effect of Modified Wupi Decoction in the treatment of corneal edema after age-related cataract phacoemulsification OUYANG Huang-di；HUANG Ling-fei Objective To investigate the clinical effect of Modified Wupi Decoction in the treatment of corneal edema after age-related cataract phacoemulsification.Methods A total of 62 patients(62 eyes)with corneal edema after phacoemulsification of age-related cataract admitted to Department of Ophthalmology of the First Traditional Chinese Medicine Hospital in Changde City Affiliated to Hu′nan University of Chinese Medicine from January 2018 October 2020 were selected as the research objects.According to the random number table method,they were divided into the control group and the treatment group,with 31 cases(31 eyes)in each group.The control group was treated with Tobramycin Dexamethasone Eye Drops,Pralofen Eye Drops,Tobramycin Dexamethasone Eye Ointment.On the basis of the control group,the treatment group was treated with Modified WuPi Decoction.The recovery time,central corneal thickness,total effective rate and adverse reactions of corneal edema were compared between the two groups.Results The cure time of corneal edema in the treatment group was shorter than that of control group,the difference was statistically significant(P＜0.05).After 3 days and 7 days,the thickness of central corneal edema in the treatment group was lower than that in the control group,the difference was statistically significant(P＜0.05).The total effective rate of the treatment group(96.7%)was higher than that of the control group(80.6%),the difference was statistically significant(P＜0.05).There was no serious adverse reactions occurred in both groups.Conclusion Modified Wupiyin in the treatment of corneal edema after age-related cataract phacoemulsification can effectively reduce the degree of corneal edema,shorten the recovery time of corneal edema,and has low incidence of adverse reactions,which has a certain promotion value in clinical practice. 2021 Vol. 28 (15): 148-151 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 152 Comparison of the effect of one-time root canal therapy and conventional root canal therapy on acute pulpitis JIANG Ming-ying；CHEN Xiao-cui；DAI Lin-zhong Objective To compare the clinical effect of one-time root canal therapy and conventional root canal therapy for acute pulpitis.Methods The clinical data of 90 patients with acute pulpitis who were admitted to Wuyishan Municipal Hospital from March 2019 to March 2020 were retrospectively reviewed.Patients were divided into the control group(n=45)and the observation group(n=45)according to the different treatment protocol.The control group received conventional root canal therapy,while the observation group implemented one-time root canal therapy to compare the clinical efficacy,pain improvement,prognostic effect and quality of life between the two groups.Results There was no significant difference in the total treatment response rate between the two groups(P＞0.05).The visual analog scale(VAS)score of pain after treatment in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The total complication rate and recurrence rate of the observation group were lower than those of the control group,with statistically significant differences(P＜0.05).There was no significant difference in quality of life(SF-36)scores between the two groups before treatment(P＞0.05).The scores of SF-36 in the two groups after treatment were higher than those before treatment,and the scores of SF-36 in the observation group was higher than those in the control group,with statistically significant differences(P＜0.05).Conclusion In the clinical treatment of acute pulpitis,both one-time root canal treatment and conventional root canal treatment have significant therapeutic effects,but one-time root canal treatment has a more active application in improving its prognosis and quality of life value. 2021 Vol. 28 (15): 152-154 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 155 Significance of contrast-enhanced ultrasound combined with color ultrasound in the differential diagnosis of primary hepatic carcinoma and metastatic hepatic carcinoma MAO Nan；LU Guan-nan Objective To investigate the significance of differential diagnosis of primary hepatic carcinoma(PHC)and metastatic hepatic carcinoma(MHC)by contrast-enhanced ultrasound(CEUS)combined with color ultrasound.Methods A total of 92 patients with liver cancer admitted to Tieling Central Hospital from June 2018 to October 2019 were selected as the research subjects.According to different etiology,they were divided into the PHC group and the MHC group,with 46 cases in each group.CEUS and color ultrasound were used in the PHC group,and the methods of examination in the MHC group were the same as those in the PHC group.The detection rates of CEUS,color ultrasound and CEUS combined with color ultrasound were compared between the two groups,as well as the blood perfusion and blood supply in the CEUS and color ultrasonography.Results The peak time of the PHC group was longer than that of the MHC group,and the enhancement intensity was higher than that of the MHC group,the differences were statistically significant(P＜0.05);the initial increase time of the MHC group was longer than that of the PHC group,the enhancement rate and 50% clearance slope were higher than that of the PHC group,the differences were statistically significant(P＜0.05).The flow velocity of hepatic artery in the PHC group was shorter than that in the MHC group,the difference was statistically significant(P＜0.05).The detection rate of CEUS combined with CDUS was higher than that of CEUS and CDUS,the difference was statistically significant(P＜0.05).Conclusion CEUS combined with color ultrasound can obtain higher differential diagnosis value for PHC and MHC,and has clinical application significance. 2021 Vol. 28 (15): 155-158 [Abstract] ( 32 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 159 Clinical value of ultrasound observation of bilateral uterine artery pulsatility index in diagnosis of tubal pregnancy WANG Bi-li Objective To investigate the value of ultrasound observation of bilateral uterine artery pulsatility index(PI)in the diagnosis of tubal pregnancy(TP).Methods A total of 90 TP patients admitted to the First People′s Hospital of Fuzhou from July 2018 to April 2020 were selected as the observation group;a total of 30 early intrauterine pregnant women who were examined in the First People′s Hospital of Fuzhou during the same period were selected as the control group.According to the difference between the position of the corpus luteum and β-human chorionic gonadotropin(βhCG)in the observation group,they were divided into group A(luteal body and TP on the same side,β-hCG＞800 mU/mL)and group B(luteal and TP on the same side,β-hCG≤800 mU/mL),group C(different side of corpus luteum and TP),with 30 cases in each group.Ultrasound detection was performed in both groups.Ultrasound diagnosis results in the observation group were analyzed and the difference between bilateral PI and PI in the two groups was compared.Results The coincidence rate of ultrasonic diagnosis of TP was 82.22%.Pregnancy corpus luteum was seen in all 90 TP patients.Ultrasonographic findings of group A and group B showed that diastolic blood pressure on the functional side was rich in blood flow signals,and blood flow resistance was decreased compared with that on the contralateral side.In group C,ultrasound imaging showed moderate resistance flow in bilateral uterine arteries.There was no significant difference in PI between non-functional side and functional side in control group,B group and C group(P＞0.05).PI of the non-functional side was higher than that of the functional side in group A,and the difference was statistically significant(P＜0.05).There was no statistical significance in the difference of bilateral PI between group B,C and control group(P＞0.05).The difference of PI in group A was higher than that in control group,group B and group C,and the difference was statistically significant(P＜0.05).Conclusion The application of ultrasonic detection of bilateral uterine artery PI in the diagnosis of tubal pregnancy can improve the objectivity and diagnostic nature of clinical diagnosis and promote the development of clinical diagnosis and treatment,which is worthy of practice and promotion. 2021 Vol. 28 (15): 159-161转165 [Abstract] ( 34 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 162 Effect analysis of quantitative count of bacteria in urinary sediments on screening of urinary system infection YE Li-ya；MA Cai-yun；LU Feng-quan；WU Ming Objective To explore the effect of quantitative count of bacteria in urinary sediments on screening of urinary system infection.Methods The urine samples of 400 patients with urinary tract infection were collected from Shengze Hospital Affiliated to Nanjing Medical University from January 2017 to December 2019 were selected as the research subjects,all patients were collected middle urine and carried out urine bacterial culture and quantitative count of bacteria in urinary sediments.Using the urine bacterial culture results as the gold standard,the sensitivity,specificity,accuracy and false positive rate of quantitative counting of urine sediment bacteria were observed.Results Among 400 specimens,the positive rate of urine bacteria culture was 50.50%(202/400),and the positive rate of quantitative count of urine sediment bacteria was 51.25%(205/400),two methods were consistent in positive detection rate(Kappa value=0.865).Using urine bacteria culture as the gold standard,the quantitative count of bacteria in urinary sediments was 79.21%(160/202),the specificity was 77.27%(153/198),the accuracy was 78.25%(313/400),and the false positive rate was 21.95%(45/205).The accuracy of quantitative count of bacteria in urinary sediments in the diagnosis of Gram-negative bacteria was 73.50%(294/400),the sensitivity was 67.31%(105/156),and the specificity was 74.41%(189/254);the accuracy in the diagnosis of Gram-positive bacteria was 92.00%(368/400),the sensitivity was 72.00%(36/50),the specificity was 94.86%(332/350);the accuracy in the diagnosis of chlamydia was 94.00%(376/400),the sensitivity was 66.67%(4/6),the specificity was 94.42%(372/394).Conclusion Although urine bacterial culture and urinary sediment quantitative counting has fair positive detection rate,urinary sediment quantitative counting still can not be replaced and may be considered as early screening indicators of urinary system infection. 2021 Vol. 28 (15): 162-165 [Abstract] ( 37 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 166 Effect of triple bag transfer method on cord blood processing WU Jie-ying；CHEN Jin-song；WU Shao-qing；LU Yan；TANG Xue-wei；LI Yan Objective To investigate the effect of tripe bag transfer method on the processing of cord blood total nucleated cells under aseptic surroundings.Methods A retrospective analysis of umbilical cord blood processing data from Guangzhou Cord Blood Bank from April 2019 to July 2020 and divided into traditional method group(267 cases)and transfer method group(278 cases)according to the separation method.The quality and efficiency of umbilical cord blood processing by the traditional secondary centrifugation method and the triple bag transfer method after transferring cord blood to empty bags and centrifuging were compared,and the quality indexes of cryopreservation volume,red blood cell removal rate,total nucleated cell number and recovery rate,CD34 positive cell number and progenitor cell colony number were compared between the two methods.Results The average cryopreservation volume of cord blood in the transfer method group was lower than that in the traditional method group,and the progenitor cell colonies in the transfer method group were higher than that in the traditional method group,and the differences were statistically significant(P＜0.05).There were no significant differences in the total number of nucleated cells,the recovery rate of nucleated cells,the depletion rate of red blood cells and the number of CD34 positive cells between the two groups(P>0.05).Conclusion The tripe bag transfer method is a simple,feasible alternative for umbilical cord blood processing without more cost,which is shows a practical value for product quality improvement in routine cord blood banking. 2021 Vol. 28 (15): 166-169 [Abstract] ( 44 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 170 Informationized emergency response construction and exploration in COVID-19 community traditional Chinese medicine prevention and control XIE Hua；LIN Jie；ZHANG Ling；ZHANG Li；CHEN Yan-li；ZHANG Guo-song During the COVID-19 epidemic prevention period,Wuchang District of Wuhan in accordance with the needs of traditional Chinese medicine(TCM)epidemic prevention and control,built several TCM information platforms to carry out TCM prevention and control work in an emergency.The establishment of the doctor-patient interactive medical management platform ensures the smooth progress of the distribution of TCM Tongzhi Prescription,realizes the dynamic communication between the expert group,community medical staff and patients,and enables the real-time monitoring and treatment adjustment of patients.The establishment of the information support platform for patient management at the isolation point provides the whole process support for TCM prevention and control management at the isolation point.The information support platform for the management of patients in the rehabilitation period establishes a set of continuous and complete health records for each patient in the rehabilitation period,so as to monitor and analyze the changes of antibodies,assess the sequelae,and provide health intervention programs of TCM.The establishment of the emergency information platform has provided a solid foundation and guarantee for the smooth implementation of TCM prevention and control work in COVID-19 communities. 2021 Vol. 28 (15): 170-173转177 [Abstract] ( 54 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 174 “Internet+”establishment of a new regional whole process information management model for ischemic stroke LI Zhuo-wei；YANG Jian-ping；LI Fei；GONG Han-xian Objective To explore the application value of"Internet+"new information management model of ischemic stroke area or sex.Methods Forty-nine patient swith ischemic stroke admitted to the Emergency Department of Nanhai District People′s Hospital of Foshan City from January to June 2019 were selected as the control group,and forty-nine patients with ischemic stroke who were treated in the new mode of“Internet+”regional whole process information management of ischemic stroke from July to December 2019 were selected as the observation group.The emergency time,hospitalization time,complications and treatment results of the two groups were compared.Results The time from onset to admission,from admission to intravenous thrombolysis,from admission to arterial puncture,from admission to revascularization and hospitalization in the observation group were shorter than those in the control group,the differences were statistically significant(P＜0.05).The bleeding conversion rate,recurrence rate and mortality rate of the observation group after thrombolysis were lower than those of the control group,and the total effectiveness of treatment was higher than that of the control group,the differences were statistically significant(P＜0.05).Conclusion“Internet+”regional whole process information management model of ischemic stroke can improve the efficiency of ischemic stroke treatment,reduce the occurrence of complications and improve the treatment results. 2021 Vol. 28 (15): 174-177 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 178 Effect of the trinity hospital sensation management model on the occurrence of nosocomial infections in pharmacy intravenous admixture service WANG Rong-juan；HE Yong；LIAO Jian-qiao Objective To explore the application effect of the trinity hospital sensation management model on preventing the occurrence of nosocomial infections in pharmacy intravenous admixture service(PIVAS).Methods A total of 35 PIVAS drug configuration staff in Ganzhou People′s Hospital from January 2018 to January 2019 were selected as the research objects.According to the implementation time of the trinity hospital sense management mode,they were divided into pre-implementation(January 2018-January 2019)and post-implementation(February 2019-January 2020).Before the implementation of the trinity hospital sense management mode,the traditional management mode was adopted.The cleanliness and hygiene quality,microbiology detection,air particle detection and nosocomial infection were compared before and after implementation.Results After implementation,the qualified rate of the staff dressing,operating countertops,ground disinfection,container disinfection,sedimentation bacteria,object surface,hand hygiene,third-party annual inspection and maintenance party monthly inspection were higher than the pre-implementation,the differences were statistically significant(P＜0.05).No hospital infection occurred before and after the implementation.Conclusion The trinity hospital sensation management model can improve the PIVAS sanitation quality,microbiological testing and air particle testing qualification rate,and enhance the effect of nosocomial infection control. 2021 Vol. 28 (15): 178-180转185 [Abstract] ( 27 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 181 Application of big data in price management under the new situation of medical reform LI Ran Objective To adopt the new situation of medical reform,innovate the mode of price supervision and improve the level of price management.Methods Aiming at the shortcomings of the traditional price supervision mode,such as single management lag and lack of foresight,the hospital information system(HIS)of a hospital was used to analyze and sum up the charging items,so as to effectively identify the price violations in clinical departments.Results The amount withheld for seven months before and after big data regulation were compared,the total amount of refusing payment decreased from 346 600 yuan to 151 200 yuan,a decrease of 56.4% compared with the previous period,and price related disputes decreased from 8 cases to 2 cases.Conclusion The addition of big data supervision has improved the level of price management,but it still needs to be strengthened in the aspects of information construction,personnel training,comprehensive development of various supervision methods,and improvement of performance management,so as to improve the level of price management,reduce illegal charges,rationalize medical charges and improve patient satisfaction. 2021 Vol. 28 (15): 181-185 [Abstract] ( 35 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 186 Application of data management of specialized nursing quality index in the prevention of medical adhesive-related skin injury WANG Dan；KUANG Hong-mei；LIAN Jia Objective To explore the application effect of specialist nursing quality index data management in the prevention of medical adhesive-related skin injury(MARSI).Methods The clinical data of 1138 patients treated with medical viscose in the Department of Neurology Intensive Care Unit(ICU)of the First Affiliated Hospital of Nanchang University from January 2017 to December 2018 were retrospectively analyzed.A total of 555 patients admitted from January 2017 to December 2017 were enrolled as the control group,and 583 patients admitted from January 2018 to December 2018 were enrolled as the observation group.The control group adopted the conventional nursing management method,while the observation group adopted the specialized nursing quality index data management method.The incidence of MARSI,the frequency of MARSI in different parts,the score of nurses′knowledge,belief and action of MARSI and the implementation rate of MARSI preventive measures were compared between the two groups.Results The incidence of MARSI in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the site of MARSI between the two groups(P＞0.05).The total score of MARSI of nurses in December 2018 was higher than that in December 2017,and the difference was statistically significant(P＜0.05).In 2018,the implementation of various preventive measures showed an overall upward trend every quarter.Conclusion The data management of specialized nursing quality index can effectively reduce the incidence of MARSI,improve nurses′knowledge and practice of MARSI,so as to improve nursing quality. 2021 Vol. 28 (15): 186-188 [Abstract] ( 34 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 189 Analysis of microbial monitoring results and countermeasures of drinking water in Fengcheng City in 2018 HUANG Zeng；ZHAO Wei-hong；DING Xin-yue；ZHAN Zhuo-peng；ZOU Jin-qun Objective The microbial pollution of drinking water in urban and rural Fengcheng City in 2018 was analyzed to provide basis and corresponding technical guidance for improving drinking water quality.Methods During 2018,drinking water including urban centralized water supply,small-scale centralized water supply and decentralized water supply was regularly collected,accordance to the national standard GB/T 5750.12-2006,the total coliform group in water was determined by multi-tube fermentation method,and the microbial indexes were detected.Results In 2018,a total of 205 water samples were tested,of which 73 were substandard,with a failure rate of 35.61%.The unqualified rate of decentralized water supply in watery period was the highest,which was 81.03%.The factory water of urban centralized water supply all met the national standards,with the lowest unqualified rate,so did small-scale centralized water supply in watery period.The unqualified rate of urban centralized water supply source water was 75.00%.Both of urban centralized water supply tap water supply and the small centralized water supply in dry season had 5.00% unqualified rate.Conclusion In 2018,Fengcheng urban centralized water supply source water microorganism pollution is serious,it is necessary to strengthen the management of water source water to ensure the safety of water source water.The microorganism pollution of distributed drinking water supply is very serious,so it is necessary to change the distributed drinking water supply mode,and suggest that the distributed water supply should be changed into small centralized water supply.It is necessary to strengthen disinfection treatment and water quality monitoring,and establish a step-by-step monitoring and supervision reporting mechanism of"village→village committee→town→city"to ensure the safety of drinking water for urban and rural residents. 2021 Vol. 28 (15): 189-191 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 192 Application effect of compound neutralization eluent in monitoring microorganism on high frequency contact surface in surgical ward under novel coronavirus pneumonia outbreak situation LU Jing；XU Bao-hua；HUANG Yan-xiang Objective To investigate application effect of compound neutralization eluent in monitoring microorganism on high frequency contact surface in surgical ward under novel coronavirus pneumonia(COVID-19)outbreak situation.Methods A total of 300 microbiological specimens were selected from the high-frequency contact tables(dressing room table,door handle,computer keyboard,elevator keys and landline telephone)in the surgical ward of the Third Affiliated Hospital of Gannan Medical College from June to November 2020,and divided into observation group(n=150)and control group(n=150)according to the type of eluent.Compound neutralization eluent was used in the observation group and normal saline eluent was used in the control group.The over-standard rate of total number of colonies and the satisfaction of the staff to the effect of eluent were compared between the two groups.Results The over-standard rate of total contact surface colonies in observation group was 20.0%,which was higher than that in control group(8.0%),the difference was statistically significant(P＜0.05).The satisfaction rate of the observation group was 93.3%,which was higher than that of the control group(66.7%),the difference was statistically significant(P＜0.05).Conclusion In the context of COVID-19 epidemic,the application effect of compound neutralization eluent in the monitoring of high-frequency contact surface microorganisms in surgical ward was better than that of conventional saline eluent,which could improve the detection rate of microorganisms exceeding the standard and facilitate the culture of residual microorganisms after disinfection. 2021 Vol. 28 (15): 192-194 [Abstract] ( 32 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 195 Thoughts on the training mode of professional master postgraduates in oncology KONG Xian-shu；ZOU Tian-ning；ZHANG Yun-jiao；DUAN Jia-jun；LUO Qing-song；LI Zhen The training goal of professional master postgraduates in oncology is to build high-quality applied oncology specialists.However,due to the particularity of oncology,there is currently no clear and reference training mode in China.The authors comprehensively analyzed the current training model and subject characteristics of the current professional master postgraduates in oncology,combined with the actual situation of the hospital,with the goal of cultivating high-quality applied specialists,from curriculum arrangement,practice ability and innovation training,and team building in teachers,the deficiency of current training mode is analyzed and summarized,and proposed corresponding suggestions for future improvements,with a view to improving the quality of training for professional master postgraduates in oncology in China. 2021 Vol. 28 (15): 195-199 [Abstract] ( 46 ) HTML (41 KB)  PDF  (0 KB)  ( 7 ) 200 Application value of PBL teaching mode based on automatic breast volume scanning imaging for interns to master breast imaging reporting and data system CHEN Jia-hui；LIU Tao；GONG Ya-fei PAN Yu；FENG Su-hua；ZHOU Miao；FENG Zi-yan；LIANG Wei-xiang The internship stage is a necessary process for medical students to go from campus to clinical work.Due to the limitations of traditional teaching mode and other factors,interns can not master ultrasound knowledge firmly and have low learning enthusiasm.In this study,automatic breast volume scanning(ABVS)and breast imaging reporting and data system(BI-RADS)are applied into the problem-based learning(PBL)teaching mode of interns in the department of medical imaging.Through the final assessment and analysis,it is found that this new teaching mode is not only beneficial for imaging interns to observe ultrasonic images of lesions,improve the diagnosis rate of breast diseases and master BI-RADS classification standards,which could increase the learning initiative of interns to a certain extent and lay a foundation for future work,but also for trainees to improve their own medical professional knowledge level and clinical teaching ability,which is worthy of promotion. 2021 Vol. 28 (15): 200-203 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 204 Discussion on how to improve the doctor-patient communication ability of standardized training surgeons YANG Hua-chao；OUYANG Wei-wei；YANG Zai-liang Good doctor-patient communication plays an important role in avoiding medical disputes and improving patient satisfaction.At present,the contents of standardized training for residents pay more attention to clinical professional knowledge and skills,and the training of doctor-patient communication ability is relatively lacking.However,the doctor-patient communication in surgery has its own characteristics before,after and during the perioperative period.This paper discussed the problems and causes of doctor-patient communication ability in standardized training of surgeons,including lack of doctor-patient communication training and guidance,lack of clinical professional knowledge,lack of active communication awareness,lack of communication skills and methods,and lack of humanistic literacy education,and proposes to improve doctors and patients during surgical regulation training by strengthening doctor-patient communication training and assessment,improving professional technical level and clinical comprehensive ability,improving the active communication awareness and communication skills of regular doctors,and strengthening humanistic quality education.so as to strengthen the humanistic quality education and the cultivation of comprehensive ability of surgeons. 2021 Vol. 28 (15): 204-206 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 207 Application of standardized training in improving clinical work ability of newly-employed nurses XIE Dong-mei；ZHENG Ying；WANG Hui-xin；WANG Xiao-fen Objective To explore the application effect of standardized training in improving the clinical work ability of newly-employed nurses.Methods A total of 110 newly recruited nurses in Ciyun Hospital of Jieyang City from June 2018 to August 2019 were selected as the research subjects and divided into control group(55 nurses)and research group(55 nurses)according to random number table method.The control group was trained by traditional distributed teaching mode,while the research group was trained by centralized training and post rotation according to the requirements of Standardized Training Outline for New Nurses(Trial).The theoretical knowledge assessment scores,operational skills assessment scores and post competence scores of the two groups were compared in one year.Results The results of theoretical knowledge examination,operational skills examination and the total score of post competence of the research group were higher than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Standardized training is a scientific,standardized,practical and comprehensive on-the-job training means,which can effectively improve the clinical work ability of new nurses. 2021 Vol. 28 (15): 207-209转213 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 210 Application of Green model in the process of nurses′protection education in operating room SU Yun-ping；WANG Ya-ling Objective To analyze the effect of applying Green model in the protection education process of operating room nurses on the protection of electrosurgical smoke.Methods A total of 22 operating room nurses who worked in Fujian Provincial Jinshan Hospital from January to September 2020 were selected as observation objects,and they were divided into two groups by computer randomization method,with 11 cases in each group.The control group received conventional protection education,and the experimental group received Green model protection education.The protection awareness,protection attitude and protection behavior of the two groups before and after intervention were analyzed.Results After intervention,the items protection awareness of the smoke source,smoke composition,impact on health and protective measures scores in the experimental group were(26.89±2.45),(8.84±1.22),(13.24±1.05),(17.77±2.35)points,all higher than those in the control group of(20.11±2.47),(6.11±1.26),(11.23±1.33),(14.90±2.65)points,the differences were statistically significant(P＜0.05).There was statistically significant difference in the protective attitude of the operating room between the two groups after intervention(P＜0.05).There was statistically significant difference in the protective behavior of the operating room between the two groups after intervention(P＜0.05).Conclusion Applying the Green model to promote the protection of electrosurgery smoke for nurses in the operating room is obvious,which can improve the awareness and recognition of electrosurgery smoke protection by operating room nurses,so as to actively take effective protective measures. 2021 Vol. 28 (15): 210-213 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 214 Development and application of standardized training program for trainee nurses in otolaryngology department XIE Jia-jia；CHEN Rong；GUO Deng-bin；LUO Jing-yi Objective To explore the formulation and application effect of standardized training program for trainee nursing students in otolaryngology department.Methods Thirty nursing students in the Department of Otolaryngology,Mindong Hospital Affiliated to Fujian Medical University from May to June 2019 were selected as the research objects.According to the random number table method,they were divided into control group(15 students)and observation group(15 students).The control group received conventional training method,and the observation group received standardized training program.The qualified rate of examination results,nursing teaching results and clinical evaluation scores of the two groups were compared.Results The qualified rate of the observation group was 100%,which was higher than 86.6% of the control group,the difference was statistically significant(P＜0.05).The results of nursing teaching in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).The clinical evaluation scores of observation group were higher than those of control group,the differences were statistically significant(P＜0.05).Conclusion The development and implementation of standardized training programs for otolaryngology nursing interns have a significant effect,which can effectively improve the training effect of interns,improve nursing teaching performance and clinical evaluation scores,and facilitate them to better carry out otolaryngology specialist nursing work. 2021 Vol. 28 (15): 214-216转220 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 217 Application of pathway health education based on department quality control team in patients with myelodysplastic syndrome SUN Ting-ting Objective To explore the application effect of path health education based on department quality control group in patients with myelodysplastic syndrome(MDS),in order to provide guidance for the selection of clinical nursing plan for MDS patients.Methods The clinical data of 80 patients with MDS admitted to Liaoyang Central Hospital from May 2019 to May 2020 were retrospectively analyzed.Data of patients who received routine health education intervention from May to November 2019 were included in the control group(39 cases),and data of patients who received path health education based on department quality control group from December 2019 to May 2020 were included in the observation group(41 cases).The degree of disease knowledge mastery,medical coping modes questionnaire(MCMQ)score and the incidence of adverse events during the intervention were compared between the two groups before intervention,1 month after intervention and 3 months after intervention.Results After intervention 1 and 3 months,the disease knowledge of the observation group were higher than those of the control group,the differences were statistically significant(P＜0.05).Three months after the intervention,the face score of the observation group was higher than that of the control group,and the yield and avoidance scores of the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).The total incidence of adverse events in observation group was lower than that in control group,the difference was statistically significant(P＜0.05).Conclusion Pathway health education intervention based on department quality control group in MDS patients can improve cognition of the disease,improve coping style,and reduce the incidence of adverse events,which is worthy of promotion. 2021 Vol. 28 (15): 217-220 [Abstract] ( 35 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 221 Application of nursing intervention under the model of bio-psycho-social medicine in patients with bipolar disorder WANG Jing Objective To observe the application of nursing intervention under the model of bio-psycho-social medicine in patients with bipolar disorder.Methods A total of 80 patients with bipolar disorder who were admitted to the Department of Psychiatry,the Fifth People′s Hospital of Jiujiang from June 2018 to June 2020 were selected as the research subjects.Patients were divided into control(n=40)and observation(n=40)groups using the random number table method.The control group was used routine nursing care,and the observation group was added nursing intervention under the biological-psychological-social medicine model on the basis of the control group.The manic state(Beck-Lafansen mania scale[BRMS])and quality of life(quality of life Scale[SF-36])of the two groups before and after intervention were compared.Results Before intervention,there were no significant differences in BRMS and SF-36 scores between the two groups(P＞0.05).After 45 days of intervention,the BRMS scores of the two groups were lower than those before intervention,and the BRMS scores of the observation group was lower than that of the control group,the differences were statistically significant(P＜0.05).After 45 days of intervention,the scores of SF-36 in both groups was higher than that before intervention,and the score of SF-36 in observation group was higher than that in control group,the differences were statistically significant(P＜0.05).Conclusion Nursing intervention under the bio-psychosocial medicine model can reduce the mania of patients with bipolar disorder and improve the quality of life of patients,which is worthy of application. 2021 Vol. 28 (15): 221-223 [Abstract] ( 40 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 224 Effect of humanist officers on hope level and treatment compliance of patients with rectal cancer with neoadjuvant radiotherapy and chemotherapy CHEN Yu-lan；ZHANG Jie-ling；HUANG Fen Objective To explore the effect of humanist officers on hope level and treatment compliance of patients with rectal cancer with neoadjuvant radiotherapy and chemotherapy.Methods A total of 62 rectal cancer patients who were treated with neoadjuvant chemoradiotherapy in the Second Affiliated Hospital of Nanchang University from January 2018 to December 2019 were selected as study subjects.The patients were divided into control group(n=31)and study group(n=31)according to random number table method.Conventional intervention method was used in the control group and conventional intervention+humane care method was used in the study group.Patients in both groups underwent intervention for 20 days.The level of hope,treatment adherence were compared between the two groups.Results Before the intervention,there was no significant difference in the hope level scores between the two groups(P＞0.05).After the intervention,the hope level score of both groups was higher than that before the intervention,and the hope level score of the study group was higher than that of the control group,and the differences were statistically significant(P＜0.05).After the intervention,the adherence to treatment in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion In the nursing of patients with neoadjuvant radiotherapy and chemotherapy for rectal cancer,To give humane care to patients,can help patients improve treatment compliance and hope level. 2021 Vol. 28 (15): 224-226 [Abstract] ( 33 ) HTML (29 KB)  PDF  (0 KB)  ( 6 ) 227 The influence of AIDET communication mode on coping style and treatment compliance of depression patients undergoing r-TMS treatment MAO Zhong-zhen；WANG Lu；LI Shui-lan Objective To explore the influence of Acknowledge-Introduce-Duration-Explanation-Thanks(AIDET)communication mode on coping style and treatment compliance of depression patients undergoing repeated transcranial magnetic stimulation(r-TMS)treatment.Methods A total of 82 depressed patients treated with r-TMS in the Third People′s Hospital of Ganzhou City from July 2018 to June 2020 were selected as study subjects.The patients were divided into control and observation groups by random number table method,with 41 cases in each group.The control group adopted usual care intervention during treatment,and the observation group adopted the aidet communication mode on the basis of the control group,and both groups continued the intervention for 8 weeks.Coping styles,depression and treatment adherence were compared between the two groups before and after the intervention.Results There was no significant difference in short form coping style questionnaire scores(SCSQ)between the two groups before intervention(P＞0.05).After intervention,the positive dimension score of SCSQ in the two groups was higher than that before intervention,and the negative dimension score was lower than that before intervention,and the differences were statistically significant(P＜0.05).After intervention,the positive dimension score of SCSQ in the observation group was higher than that in the control group,and the negative dimension score was lower than that in the control group,and the differences were statistically significant(P＜0.05).The treatment adherence of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in Hamilton depression scale(HAMD)between the two groups before intervention(P＞0.05).After the intervention,the HAMD scores of the two groups were lower than those before the intervention,and the HAMD scores of the observation group wer e lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion The AIDET communication mode can improve the coping style of patients with depression treated with r-TMS,improve treatment compliance,and reduce the degree of depression. 2021 Vol. 28 (15): 227-229转233 [Abstract] ( 40 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 230 Effect of whole course nursing mode on patients undergoing painless gastroscopy combined with colonoscopy RAO Dan-xia Objective To explore the effect of whole course nursing mode on patients undergoing painless gastroscopy combined with colonoscopy.Methods A total of 80 patients with painless gastrointestinal examination in the First People′s Hospital of Fuzhou City in Jiangxi Province from May 2018 to October 2020 were selected for prospective study.They were divided into the control group and the observation group according to random number table method,with 40 cases in each group.The control group was treated with routine nursing mode,while the observation group was treated with whole course nursing mode.Blood pressure,heart rate and self rating anxiety scale(SAS)scores of the two groups were compared,the effect of whole course nursing mode on patients undergoing painless gastroscopy combined with colonoscopy by analyzing the related indexes such as SAS,self rating depression scale(SDS),anesthetic dosage,operation time and respiratory depression was analyzed.Results The systolic blood pressure,diastolic blood pressure and heart rate in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).After the intervention,the SAS and SDS scores of the observation group were lower than those of the control group,the dosage of narcotic drugs was less than that of the control group,and the incidence of respiratory depression was lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion The application of whole course nursing mode intervention in patients with painless gastroscopy combined with colonoscopy can improve the negative emotions of patients,reduce the psychological tension of patients,relieve the increase of blood pressure and heart rate induced by psychological factors,and improve the degree of cooperation of patients.At the same time,it has a positive effect on reducing the amount of narcotic drugs and reducing the incidence of respiratory depression. 2021 Vol. 28 (15): 230-233 [Abstract] ( 40 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 234 Application effect of comprehensive nursing intervention in perioperative period of patients with clavicle fracture ZOU Qin；ZHANG Jian-ping；XU Lian Objective To explore the application effect of comprehensive nursing intervention in the perioperative period of patients with clavicle fracture.Methods A total of 60 patients with clavicle fracture admitted to the Second People′s Hospital of Yichun City from June 2018 to March 2020 were selected as the research subjects.All patients were given traditional surgical treatment,and were divided into the conventional group(30 cases)and the comprehensive group(30 cases)according to the blue-red two-color number 1-30 sequence distribution.Conventional nursing intervention was given the conventional group,and comprehensive nursing intervention was given the comprehensive group.The nursing effects of the two groups were compared.Results The shoulder function scores(Constant-Murley)and rating scale of the American shoulder and elbow surgeons(ASES)scores in both groups after treatment were higher than before treatment,and the visual analogue scale(VAS)score were lower than before treatment,the scores of Constant-Murley and ASES in the comprehensive group were higher than those in the conventional group,and the VAS score was lower than that in the conventional group,the differences were statistically significant(P＜0.05).The total excellent and good rate of functional recovery in the comprehensive group was higher than that in the conventional group,and the total incidence of complications in the comprehensive group was lower than that in the conventional group,with statistical differences(P＜0.05).Conclusion Comprehensive nursing in the nursing of clavicle fracture is beneficial to the functional outcome and the reduction of complication occurrence,which has high application value. 2021 Vol. 28 (15): 234-236 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 237 Application effect of predictive nursing in Urology SHAO Ting-ting；XIAO Hui-su；MAO Li-hua Objective To explore the application value of predictive nursing in urology.Methods A total of 80 cases of urological patients admitted to the Guangxin District People′s Hospital of Shangrao City,Jiangxi Province from January 2018 to January 2020 were selected as research objects and divided into the experimental group(40 cases)and the control group(40 cases)according to the segmented randomization method.Conventional nursing methods were used in the control group,and predictive nursing methods were used in the experimental group.Anal exhaust time,bowel sound recovery time,hospital stay time,complications,nursing satisfaction were compared between the two groups.Results The time of anal exhaust,bowel sound recovery and hospital stay in the experimental group were shorter than those in the control group,with statistical differences(P＜0.05).The total complication of the experimental group was 5.00%,which was lower than that of the control group(20.00%),and the difference was statistically significant(P＜0.05).The total satisfaction of the experimental group was 97.50%,which was higher than that of the control group(80.00%),with statistical difference(P＜0.05).Conclusion The implementation of predictive nursing intervention in urology can better control the occurrence of complications in patients,shorten the recovery time,and patient satisfaction is higher,which is of great significance. 2021 Vol. 28 (15): 237-239 [Abstract] ( 44 ) HTML (29 KB)  PDF  (0 KB)  ( 5 ) 240 Clinical application of rapid rehabilitation nursing in perioperative nursing of ureteroscopic lithotripsy patients LIU Cui-lian Objective To analyze the clinical application of rapid rehabilitation nursing(FTS)in perioperative nursing of ureteroscopic lithotripsy patients.Methods From October 2018 to October 2019,106 cases patients of ureteroscopic lithotripsy treated in Beijing Fangshan District Liangxiang Hospital were selected as the research subjects.They were divided into the experimental group and the control group according to the order of admission,53 cases in each group.Both groups were treated with ureteroscopic lithotripsy.The control group was given routine perioperative nursing measures during perioperative period,while the experimental group was given FTS nursing during perioperative period.The postoperative exhaust time,out of bed time,hospitalization time,total hospitalization expenses between the two groups were compared,and the total incidence of complications such as hematuria,fever and pain between the two groups were calculated.Results The recovery time index of the experimental group such as postoperative exhaust time,time to get out of bed and hospitalization time in the experimental group were shorter than those of the control group,and the hospitalization cost was lower than that of the control group,the differences were statistically significant(P＜0.05).The total complications in the experimental group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion In the perioperative period of patients with ureteroscopic lithotripsy,FTS nursing can shorten the postoperative rehabilitation time,reduce the related complications and reduce the cost of treatment. 2021 Vol. 28 (15): 240-242 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 243 Application effect of targeted nursing in the treatment of children bronchopneumonia with traditional Chinese medicine point application combined with expectoration machine LI Hui-feng；MO Lan；XU Xia-ying Objective To explore the application effect of targeted nursing in the treatment of children bronchopneumonia with traditional Chinese medicine point application combined with expectoration machine.Methods A total of 120 children with bronchopneumonia admitted to Maternal and Child Health Hospital of Yunfu City from June to December 2019 were selected as the study subjects,and were divided into the control group and the observation group by the random number table method,with 60 cases in each group.All the children in the two groups were given acupoint application of traditional Chinese medicine combined with sputum discharge machine treatment.The control group was treated with routine nursing,and the observation group was treated with targeted nursing.The excellent and good rates of clinical disease control,time for disappearance of cough symptoms,time for disappearance of sputum symptoms,time for disappearance of pulmonary rales and length of hospital stay in the two groups were explored.Results The excellent and good rate of clinical disease control in the observation group was 96.67%,which was higher than the 83.33% in the control group,the difference was statistically significant(P＜0.05).The time for the disappearances of cough symptoms,sputum symptoms and pulmonary rales,and the length of hospital stay in the observation group were(3.02±0.21),(2.79±0.23),(2.52±0.11)and(5.91±0.39）d，which were shorter than those in the control group of（4.38±1.16）,（4.81±1.19）,(4.08±1.37)and(8.88±1.42)d,the differences were statistically significant(P＜0.05).Conclusion The application of targeted nursing in acupoint application of traditional Chinese medicine combined with sputum discharge machine in treating children with bronchial pneumonia has better effect. 2021 Vol. 28 (15): 243-245 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 246 Application effect of QCC activities on the occurrence of neonatal phlebitis and nurses′knowledge of venous indwelling needle LU Mei-jian；CHEN Li-rong；ZHEN Xing-qing；CHENG Shi Objective To explore the application effect of quality control circle(QCC)in newborns with venous indwelling needle.Methods From March 2018 to March 2019,103 children with intravenous indwelling needle puncture and infusion and 25 nursing staffs in Jiangmen People′s Hospital,Guangdong Province were selected as the control group,and routine nursing intervention was used;103 children with venous indwelling needle puncture and infusion in from April 2019 to April 2020 and 25 nursing staffs in Jiangmen People′s Hospital,Guangdong Province the same period were selected as the observation group,and QCC activity intervention was used.The incidence of phlebitis was observed and compared between the two groups.Seven days after the intervention,nurses′knowledge of venous indwelling needle was evaluated,and the family members′total satisfaction with nursing was investigated.Results The incidence of phlebitis in the observation group was 0.97%,which was lower than that in the control group(7.77%);the scores of vascular condition assessment was(22.15±2.03),the operation of venous indwelling needle was(22.32±2.01),the routine maintenance of venous indwelling needle was(22.37±2.21),prevention and nursing of complications was(22.52±2.23)and total score was(88.79±5.64)points,which was higher than those of the control group of(18.97±5.64),(20.18±2.02),(20.35±2.12),(20.28±2.16),(80.56±5.42)points,the differences were statistically significant(P＜0.05).The nursing total satisfaction of family members was 97.09%,which was higher than 87.38% of the control group,the difference was statistically significant(P＜0.05).Conclusion QCC activity intervention in venous indwelling needle neonatal application effect is good,can reduce the incidence of phlebitis,improve nursing staff on venous indwelling needle related knowledge,improve nursing satisfaction. 2021 Vol. 28 (15): 246-248转252 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 4 ) 249 Application effect of rehabilitation exercise in promoting rapid recovery of gynecological laparoscopic perioperative patients LIU Juan；LENG Wei-ting；HUANG Xiao-mei；LI Chan；WANG Xiu-xia；PENG Tao Objective To explore the application effect of rehabilitation exercise in promoting the rapid recovery of gynecological laparoscopic perioperative patients.Methods A total of 60 patients with elective gynecological laparoscopic surgery in Ganzhou Cancer Hospital,Jiangxi Province from January 2018 to January 2020 were selected as the research objects and divided into the observation group(30 cases)and the control group(30 cases)according to random number table method.The control group used traditional gynecological laparoscopic perioperative nursing methods,the observation group used perioperative rehabilitation exercise method.The psychological state score,postoperative body recovery,hospitalization time,complications and nursing satisfaction score at discharge were compared between the two groups.Results The self-rating anxiety scale(SAS)and self-rating depression scale(SDS)scores of the two groups were compared,the difference had no statistical significance(P＞0.05).The recovery time of bowel sounds,the first exhaust time of anus,the first time of getting out of bed,the time of returning to normal diet and hospitalization time in the observation group were shorter than those in the control group,the differences were statistically significant(P＜0.05).The nursing satisfaction score of the observation group was higher than that of the control group at discharge;the total incidence of postoperative complications in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion Rehabilitation exercise can improve the psychological state of patients with gynecological laparoscopic surgery,at the same time,can shorten the recovery time of patients,but also can reduce the risk of complications of patients,which is worthy of clinical recommendation. 2021 Vol. 28 (15): 249-252 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 253 Application of improved early warning score combined with information system in nursing care of gynecological inpatients JIANG Jun-yan；ZHENG Qiu-ju；DING Zhen-lan Objective To explore and analyze the application of modified early warning score(MEWS)combined with hospital information system(HIS)in the nursing of gynecological inpatients.Methods From April 2018 to April 2020,200 cases of gynecological inpatients in Xiaolan People′s Hospital of Zhongshan were selected as the research object,and divided into control group and observation group by random grouping method,with 100 cases in each group.The control group was treated with routine nursing care,while the observation group was treated with MEWS score combined with HIS on the basis of the control group.The condition of nurses,nursing satisfaction of patients and the sensitivity index of nursing quality in the two groups were compared.Results The score of nursing staff in observation group was higher than that in control group,and the difference was statistically significant(P＜0.05).The satisfaction of observation group was higher than control group,and the difference was statistically significant(P＜0.05).The sensitivity index of nursing quality in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion MEWS score combined with HIS has a relatively good effect in the nursing of gynecological inpatients,which can effectively grasp the patient′s condition,ensure the life safety of patients,and improve the medical satisfaction of patients.It is worthy of clinical promotion and application. 2021 Vol. 28 (15): 253-255 [Abstract] ( 42 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 256 Application of evidence-based nursing intervention based on the concept of enhanced recovery after surgery in the management of aspiration risk of patients after posterior fossa tumor FANG Yan-ya；CHEN Cai-di；JIANG Ya-lan；DENG Mi-xia；HUANG Kai-yan Objective To explore the application effect of evidence-based nursing intervention based on the concept of enhanced recovery after surgery(ERAS)in patients undergoing posterior fossa tumor surgery.Methods A total of 104 posterior fossa tumor patients who were admitted to Jiangmen Central Hospital in Guangdong Province from March 2019 to March 2020 were selected.They were divided into two groups according to random number table method,52 cases in each group.In the control group,routine aspiration risk management was used,and in the observation group,evidencebased nursing intervention based on the concept of ERAS was adopted.The improvement of swallowing function,the score of food intake ability,the time of gastric tube removal,and the incidence of aspiration were compared between the two groups.Results The total improvement rate of swallowing in the observation group was 96.15%,higher than that of the control group accounting for 82.69%,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the food intake ability of the two groups on the first day after surgery(P＞0.05).In the observation group,the food intake ability score on the 7th day after surgery was(5.49±0.87)points,which was higher than the 1st day after the operation for(3.95±1.15)points.In the control group,the food intake ability score on the 7th day after surgery was(4.73±1.04)points,higher than the 1st day after surgery for(3.52±1.08)points,with statistical differences(P＜0.05).On the 7th day after surgery,the food intake ability score of the observation group was(5.49±0.87)points,higher than that of the control group of(4.73±1.04)points,and the difference was statistically significant(P＜0.05).The removal time of gastric tube in the observation group was(5.82±1.46)d,shorter than that of the control group of(6.92±1.63)d,and the difference was statistically significant(P＜0.05).The incidence of aspiration in the observation group was 1.92%,lower than that of the control group accounting for 15.38%,and the difference was statistically significant(P＜0.05).Conclusion Based on the ERAS concept,evidence-based nursing intervention can improve the swallowing function and food intake ability of patients with posterior fossa tumor surgery,reduce the incidence of aspiration,and speed up the recovery of patients after surgery. 2021 Vol. 28 (15): 256-258转262 [Abstract] ( 37 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 259 Effect of evidence-based nursing management plan on reducing complications of indwelling needle YE Gui-fang；ZHANG Yun-mei；LI Xing-yu；LIANG Xue-mei Objective To explore the effect of evidence-based nursing management program in reducing complications of indwelling needles.Methods A total of 308 patients treated with indwelling needles who were admitted to Guangzhou Panyu District Central Hospital from May to September 2019 were selected.They were divided into the control group and study group according to random number table method,with 154 cases in each group.The control group used routine management,and the study group used evidence-based nursing management.The nursing effect was compared between the two groups.Results The blood return rate(3.9%),blockage rate(4.5%),and extravasation rate(3.2%)of the study group were lower than those of the control group of 22.7%,9.7%,and 8.4%,the differences were statistically significant(P＜0.05).The incidence of pain in the study group(5.8%)was lower than that of the control group(12.9%),and the difference was statistically significant(P＜0.05).The total satisfaction of the study group(98.7%)was higher than that of the control group(89.0%),the difference was statistically significant(P＜0.05).Conclusion Evidence-based nursing management plan for patients who use indwelling needles has an ideal effect,which can reduce the probability of recurrence and extravasation,reduce the occurrence of pain,and improve the quality of care and satisfaction. 2021 Vol. 28 (15): 259-262 [Abstract] ( 38 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 263 Effect of operating room insulation nursing in reducing postoperative stress response and complication in patients undergoing general anesthesia surgery SUN Yue-qin Objective To explore the effect of operating room insulation nursing in reducing postoperative stress response and complication in patients undergoing general anesthesia surgery.Methods A total of 68 patients undergoing general anesthesia in the Jingzhou Third People′s Hospital from May 2018 to December 2019 were selected and divided into the control group(34 cases)and the observation group(34 cases)using the random number table method.The control group was given routine nursing,while the observation group was given operating room insulation nursing.The stress index levels,total incidences of complication and total nursing satisfaction were compared between the two groups.Results The levels of epinephrine,norepinephrine,and C-reactive protein of the observation group before nursing were not statistically different from those of the control group(P＞0.05).The levels of epinephrine,norepinephrine,and C-reactive protein in the observation group after nursing were lower than those in the control group,with statistical differences(P＜0.05).The total nursing satisfaction of the observation group was higher than that of the control group,and the total incidence of complication of the observation group was lower than that of the control group,with statistical differences(P＜0.05).Conclusion The application of operating room insulation improves postoperative stress response,avoids complications as much as possible,and promotes improvement of nursing satisfaction in general anesthesia surgery.It is worthy of clinical promotion and adoption. 2021 Vol. 28 (15): 263-265 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 266 Effect of WeChat video combined with mindfulness decompression therapy in elderly patients with benign prostatic hyperplasia CHEN Ai-ping Objective To study the effect of WeChat video combined with mindfulness decompression therapy in elderly patients with benign prostatic hyperplasia(BPH).Methods From February 2018 to February 2020,153 elderly patients with BPH treated in the Affiliated Hospital of Putian University were selected and divided into the control group(76 cases)and the study group(77 cases)by random number table method.The control group received regular health education,and the study group used WeChat video combined with mindfulness decompression therapy on the basis of the control group.The anxiety,depression and quality of life between the two groups were compared.Results After the intervention,the self-rating anxiety scale(SAS)and self-rating depression scale(SDS)score of the study group were lower than those of the control group,the differences were statistically significant(P＜0.05).After the intervention,the disease,physiology,social,psychological,and satisfaction scores of the patients with benign prostatic hyperplasia(BPHQLS)in the study group were lower than those of the control group,the differences were statistically significant(P＜0.05).Conclusion WeChat video combined with mindfulness decompression therapy can effectively improve the anxiety and depression of elderly BPH patients and improve the quality of life. 2021 Vol. 28 (15): 266-268转273 [Abstract] ( 40 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 269 Nursing practice of humanistic care concept in analgesia and sedation of ICU patients with mechanical ventilation LI Miao；XIE Bi-zhan Objective To explore the application method and effect of humanistic care concept in analgesia and sedation of ICU patients with mechanical ventilation.Methods A total of 64 patients with mechanical ventilation in ICU of People′s Hospital of Hezhou City from January to December 2018 were selected as the control group,and 69 patients with mechanical ventilation in ICU of People′s Hospital of Hezhou City from January to December 2019 were selected as the study group.The control group was given routine nursing and analgesia sedation nursing,while the study group was given humanistic care concept on the basis of routine nursing.The dosage of analgesic and sedative drugs,sleep quality(RCSQ),duration of mechanical ventilation,length of ICU stay and the incidence of delirium were compared between the two groups.Results The average daily dose and the total dose of Fentanyl and Dexmedetomidine in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.01).The scores of sleep depth,difficulty of falling asleep,times of awakening,difficulty of falling asleep again and overall sleep quality of the study group were higher than those of the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in mechanical ventilation time between the two groups(P＞0.05).The length of ICU stay in the study group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).The incidence of delirium in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The application of humanistic care concept in ICU patients with mechanical ventilation can reduce the dosage of analgesic and sedative drugs,improve sleep quality,reduce the incidence of delirium,and shorten the length of ICU stay. 2021 Vol. 28 (15): 269-273 [Abstract] ( 34 ) HTML (40 KB)  PDF  (0 KB)  ( 7 ) 274 Application of comprehensive nursing intervention in nursing of patients with lumbar disc herniation treated by percutaneous transluminal foramen endoscopy ZHANG Rui-juan；ZHUANG Xi-lan；HU Peng-tao Objective To explore the effect of comprehensive nursing intervention in the nursing of patients with lumbar disc herniation(LDH)treated by percutaneous transluminal foramen endoscopy.Methods A total of 94 patients with LDH who were treated by percutaneous transluminal foramen endoscopy in Huazhong University of Science and Technology Union Shenzhen Hospital from January to April 2019 were selected as research objects.The patients were divided into the observation group and the control group by random digital table method,47 cases in each group.The patients in the control group received basic nursing intervention during perioperative period,and the patients in the observation group received comprehensive nursing intervention.The treatment and recovery effects,visual analog pain(VAS)scores and nursing satisfaction before and after operation were compared between the two groups.Results The excellence rate of the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).After different nursing interventions,the VAS scores of the two groups were lower than those before nursing,the VAS score of the observation group after nursing was lower than that of the control group,and the differences were statistically significant(P＜0.05).The comprehensive nursing total satisfaction of the observation group was 95.74%,higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Comprehensive nursing intervention for patients with LDH treated by percutaneous transluminal foramen endoscopy can significantly reduce the pain of patients and accelerate the postoperative recovery of patients. 2021 Vol. 28 (15): 274-276 [Abstract] ( 39 ) HTML (31 KB)  PDF  (0 KB)  ( 5 )

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