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Clinical effect of Huayu Kesai Decoction in the treatment of qi deficiency and blood stasis syndrome in the recovery stage of ischemic stroke |
ZANG Cui-cui |
Institute of Pulse Study,Shandong Academy of Traditional Chinese Medicine,Shandong Province,Ji′nan 250014,China |
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Abstract Objective To explore the clinical effect of Huayu Kesai Decoction in treating qi deficiency and blood stasis syndrome of ischemic stroke during convalescence.Methods From December 2017 to December 2018,60 patients admitted to the Rehabilitation Department of the Affiliated Hospital of Shandong Academy of Traditional Chinese Medicine and the Ward of the Department of Traditional Chinese Medicine of Qianfoshan Hospital in Shandong Province were selected as the research objects.They were randomly divided into the treatment group and the control group according to the digital lottery method,with 30 cases in each group.The treatment group was treated with Huayu Kesai Decoction,while the control group was treated with Naoxintong Capsules.Patients in both groups were treated for 28 days.The effective rate,traditional Chinese medicine syndrome scores of qi deficiency and blood stasis,neurological defect scoreand hemorheology indexes(high whole blood viscosity,low whole blood viscosity,plasma viscosity,platelet aggregation rate,hematocrit)and total incidence of adverse reactions in the two groups were compared.Results The effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of traditional Chinese medicine syndrome of qi deficiency and blood stasis,neurological defect score in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the whole blood high shear viscosity,plasma viscosity and platelet aggregation rate in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The therapeutic effect of Huayu Kesai Decoction on the syndrome of qi deficiency and blood stasis during the convalescent period of ischemic stroke is remarkable.
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[1] |
邱吕军,杨洁红,张宇燕,等.补阳还五汤对大鼠脑缺血再灌注损伤的脑脊液中兴奋性氨基酸的影响[J].中华中医药学刊,2016,27(10):2063-2065.
|
[2] |
中华神经科学会,中华神经外科学会.各类脑血管疾病诊断要点(1995)[J].临床和实验医学杂志,2013,12(7):559.
|
[3] |
国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准(试行)[J].北京中医药大学学报, 1996;19(1):55-56.
|
[4] |
刘晓明.化瘀克塞方治疗急性脑梗死的临床与实验研究[D].济南:山东中医药大学,2007.
|
[5] |
国家中医药管理局全国中医脑病急症科研协作组.中风病辨证诊断标准(试行)[J].北京中医药大学学报,1994,17(3):64-66.
|
[6] |
中华神经科学会,中华神经外科学会.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383.
|
[7] |
郭加兴.缺血性中风恢复期常用中药现代文献及气虚血瘀证中药干预研究[D].济南:山东中医药大学,2009.
|
[8] |
李长生,张秀清,程广清,等.化瘀克塞方治疗急性脑梗死气虚血瘀证的临床疗效观察[A].中华中医药学会老年病分会.全国中医药防治老年病学术交流会学术论文集[C].北京:中华中医药学会,2011:3.
|
[9] |
向丽,董志,李然然,等.山奈酚对脑缺血再灌注大鼠神经元超微结构及TLR4/NF-κB的影响[J].中国医院药学杂志,2015,35(10):869-873.
|
[10] |
李海刚,胡晒平,周意,等.川芎主要药理活性成分药理研究进展[J].中国临床药理学与治疗学,2018,23(11),1302-1308.
|
[11] |
马莹慧,王艺璇,刘雪,等.丹参药理活性研究进展[J].吉林医药学院学报,2019,40(6):440-442.
|
[12] |
石永光,董健健,周晟,等.“醒脑开窍”针刺法对缺血性脑卒中大鼠行为学的影响[J].云南中医学院学报,2018,41(4):25-28.
|
[13] |
洪刚,张鑫.针刺联合自拟醒脑开窍中药免煎颗粒治疗脑卒中后吞咽功能障碍的临床观察[J].中国中医急症,2019,28(7):1247-1250.
|
[14] |
黄玲.黄连化学成分及有效成分药理活性的研究进展[J].中西医结合心血管病电子杂志,2020,8(17):136-137.
|
[15] |
刘韬,朱万芸.微生物发酵三七皂苷抗脑缺血和抗血栓形成作用的研究[J].医学食疗与健康,2020,18(10):1-4.
|
[16] |
刘文雅,王曙东.地龙药理作用研究进展[J].中国中西医结合杂志,2013,33(2):282-285.
|
|
|
|