|
|
|
| Clinical effect of hyperbaric oxygen in the treatment of delayed encephalopathy after carbon monoxide poisoning |
| ZHANG Xiu-jin |
| Department of Emergency,Affiliated Hospital of Chifeng University,Inner Mongolia Autonomous Region,Chifeng 024000,China |
|
|
|
|
Abstract Objective To investigate the clinical effect of hyperbaric oxygen in the treatment of delayed encephalopathy after carbon monoxide poisoning(DEACMP).Methods A total of 68 DEACMP patients who were treated in Affiliated Hospital of Chifeng University from June 2018 to June 2020 were selected as the research objects.The patients were divided into the control group and the experimental group using the stratified sampling method,with 34 cases in each group.The control group only received routine medical treatment,while the experimental group was treated with hyperbaric oxygen on this basis.The clinical treatment effect was compared between the two groups.Results Before treatment,there were no significant differences in the scores of the ability of daily living(ADL),mini-mental state examimation(MMSE)and Montreal cognitive assessment scale(MoCA)between the two groups(P＞0.05)After treatment,the ADL score of the experimental group was lower than that of the control group,and the MMSE and MoCA scores were higher than those of the control group,with statistically significant differences(P＜0.05).The total effective rate of treatment in the experimental group(91.18%)was higher than that in the control group(79.41%),and the difference was statistically significant(P＜0.05).In terms of serum indicators,the levels of central nervous system specific protein(S100β)and neuron specific enolase(NSE)before treatment between the two groups were not statistically different(P＞0.05).After treatment,the serum S100β and NSE levels of the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).The serum S100β and NSE levels of the experimental group after treatment were lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion The combined use of hyperbaric oxygen therapy on the basis of conventional Western medicine treatment can effectively correct the symptoms of brain hypoxia,improve the patients′cognitive function,improve the ability of daily living,and then exert a significant therapeutic effect.It is worthy of promotion and implementation.
|
|
|
|
|
|
| [1] |
陈黎明，黄国亮，闫红.依达拉奉联合高压氧对CO中毒患者脑损伤的保护作用[J].西南国防医药，2019，29（1）：38-41.
|
| [2] |
李哲，李敏.一氧化碳中毒后迟发性脑病患者高压氧治疗前后磁共振成像的改变[J].中国药物与临床，2019，19（5）：727-728.
|
| [3] |
朱琦，杨越.老年急性一氧化碳中毒迟发性脑病的临床特征及预后影响因素[J].中国老年学杂志，2019，39（19）：4676-4679.
|
| [4] |
刘莹莹，刘赟，马利，等.急性一氧化碳中毒患者血清半胱氨酸天冬氨酸蛋白酶-3水平变化及其与急性一氧化碳中毒后迟发性脑病的关系研究[J].实用心脑肺血管病杂志，2020，28（4）：106-110.
|
| [5] |
黄远芳.前馈控制在预防一氧化碳中毒后迟发性脑病患者中的应用效果[J].护理实践与研究，2019，16（3）：158-159.
|
| [6] |
李晟，陈潜妙，池学锋，等.急性一氧化碳中毒后迟发性脑病预测因子的研究[J].浙江医学，2019，41（11）：1150-1153.
|
| [7] |
王运锋，胡蓉，季一飞，等.首次强化高压氧治疗重度急性一氧化碳中毒[J].西部医学，2020，32（4）：524-526，531.
|
| [8] |
王运锋，郑惠之，陈风兰，等.高压氧治疗急性一氧化碳中毒的疗效及影响因素分析[J].重庆医学，2020，49（13）：2095-2098.
|
| [9] |
尹爱华，李合群，崔雷，等.益气养血-化痰通络方对一氧化碳中毒迟发性脑病后痴呆患者的影响研究[J].实用心脑肺血管病杂志，2018，26（4）：63-66.
|
| [10] |
李锐.多奈哌齐对一氧化碳中毒后迟发性脑病患者认知障碍的疗效及安全性观察[J].中国实用神经疾病杂志，2017，20（9）：101-103.
|
| [11] |
陈文博，唐妍，王文升.醒智益脑颗粒联合高压氧治疗急性一氧化碳中毒迟发性脑病认知及活动功能障碍的临床研究[J].中西医结合心脑血管病杂志，2019，17（24）：3912-3917.
|
| [12] |
余毅娟，毛小强，徐小良，等.醒脑静结合高压氧对一氧化碳中毒患者血清基质金属蛋白酶9和中枢神经特异性蛋白水平及脑功能的影响[J].中国医药，2020，15（5）：708-711.
|
| [13] |
周磊，范茂丹，陈岳涛，等.高压氧改善一氧化碳中毒后迟发性脑病大鼠学习记忆能力及可能机制[J].生物医学工程与临床，2017，21（4）：349-355.
|
| [14] |
陈彬，蔡波.高压氧在急性一氧化碳中毒患者急救中的临床效果[J].中国医学创新，2019，16（10）：145-148.
|
| [15] |
何坚，梁晓东，黄春燕，等.养血清脑颗粒联合高压氧治疗一氧化碳中毒后迟发性脑病的临床疗效[J].广西医学，2020，42（8）：968-971.
|
| [16] |
钟德芳，蒙仁玖，高玉娟.高压氧治疗一氧化碳中毒后迟发性脑病的临床疗效观察[J].临床合理用药杂志，2016，9（11）：11-13.
|
| [17] |
周露茜，黎晓莹，关力理，等.不同频次高压氧治疗对急性中重度一氧化碳中毒患者的临床疗效评价[J].新医学，2017，48（1）：18-22.
|
|
|
|
