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Quick Search     Adv Search 2020 Vol. 27, No. 22 Published: 2020-08-08   4 Detection and clinical significance of plasma endothelin-1 and platelet pselectin in chronic obstructive pulmonary disease WANG Zhi-gang；ZHENG Hong-yan；LIN Xue-jun Objective To investigate the level and clinical significance of plasma endothelin-1 (ET-1) and platelet pselectin (CD62P) in patients with chronic obstructive pulmonary disease (COPD).Methods A total of 68 patients with acute exacerbation of COPD (AECOPD) in our hospital from June 2017 to September 2018 were selected as group A,79 patients with stable COPD who were reviewed in the same clinic were selected as the group B, and a total of 72 healthy examinees served as the healthy control group C.The plasma ET-1 and platelet surface CD62P levels of the three groups were detected and compared, and the relationship between the plasma ET-1, platelet surface CD62P levels and arterial blood oxygen partial pressure (PaO2), arterial blood carbon dioxide partial pressure (PaCO2) was analyzed in group A and B.Results The plasma ET-1 and platelet CD62P levels in group A were higher than those in group B and C, and the differences were statistically significant (P＜0.05).There were no significant differences in the levels of plasma ET-1 and platelet CD62P between group B and group C (P＞0.05).There were no significant differences in PaO2 and PaCO2 between group A and group B (P＞0.05).Plasma ET-1 and platelet CD62P levels were negatively correlated with PaO2 (r=-0.41, -0.43, P＜0.05), and positively correlated with PaCO2 (r=0.56, 0.58, P＜0.05).Conclusion The detection of ET-1 and CD62P in COPD patients is helpful for the early detection and clinical intervention of prethrombotic state (PTS) in COPD patients. 2020 Vol. 27 (22): 4-7 [Abstract] ( 36 ) HTML (41 KB)  PDF  (0 KB)  ( 6 ) 8 Evaluated effect of Clopidogrel platelet reactivity on the risk of bleeding and ischemia in patients after percutaneous coronary intervention ZHANG Jian-bo；SHI Qi-yu；HU Ya-min  Objective To investigate evaluated effect of Clopidogrel platelet reactivity on the risk of bleeding and ischemia events after percutaneous coronary intervention (PCI).Methods A total of 306 patients admitted to Cangzhou Central Hospital from January 2017 to January 2018 who had undergone PCI with drug-eluting stents and had undergone Clopidogrel platelet reactivity measurement within 48 hours after surgery were selected as the study subjects.The mean value of Clopidogrel platelet reactivity was (31.2±12.9)%.Aspirin and Clopidogrel before and after surgery were taken.Baseline information and the occurrence of bleeding and ischemia events were collected within 1 year.Results Within 1 year, bleeding events merged in 35 patients (11.4%), with ischemia events in 23 patients (7.5%).The area under the receiver operating characteristic curve (AUROC) of Clopidogrel platelet reactivity for bleeding events was 0.88,sensitivity and specificity were 74.3% and 89.3%, respectively, and the cut-off value was ≤15.0%.The AUROC of Clopidogrel platelet reactivity for ischemic events was 0.74, sensitivity and specificity were 73.9% and 77.0%, respectively, and the cut-off value was >43.7%.The number of Clopidogrel platelet reactivity in the three intervals ≤15.0%,>15.0%-43.7%, >43.7% occurring bleeding and ischemic events was 26 and 1, 9 and 5, 17 and 0, respectively.Conclusion Clopidogrel platelet reactivity presents good evaluated performance for bleeding and ischemic events in 1 year after PCI, especially for bleeding events.However, its therapeutic window needs to be further verifyed, so as to provide evidence for more individualized antithrombotic strategies. 2020 Vol. 27 (22): 8-11 [Abstract] ( 30 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 12 Influence of Taoren Chengqi Decoction combined with Western medicine sequential therapy on short-term insulin pump intensive treatment of newly diagnosed type 2 diabetes ZUO Liang；LU Zhi-lan Objective To analyze the influence of Taoren Chengqi Decoction combined with Western medicine sequential therapy on short-term insulin pump intensive treatment of newly diagnosed type 2 diabetes.Methods A total of 120 newly diagnosed type 2 diabetes patients who had received insulin pump intensive treatment for 3 weeks in the First Affiliated Hospital of Hu′nan Traditional Chinese Medical College from November 2019 to January 2020 were selected as the research objects.They were divide into group A, B, C, D according to the random number table method,30 cases in each group, and patients in four groups were treated with Exenatide, Taoren Chengqi Decoction combined with Exenatide, Liraglutide, Taoren Chengqi Decoction combined with Liraglutide respectively.The fasting plasma glucose (FPG), insulin resistance index (HOMA-IR), area under the insulin curve (AUCGln0-3 min), islet α cell function(AUCIns0-10 min), islet β cell function index (HOMA-β), body mass index (BMI) were observed and compared.Results After treatment, the FPG, HOMA-IR, AUCGln0-3 min of the four groups were lower than those before treatment, AUCIns0-10 min and HOMA-β were higher than those before treatment, the differences were statistically significant (P＜0.05).There was no statistically significant difference in BMI of the four groups between before and after treatment (P＞0.05).After treatment, there were no significant differences in FPG, HOMA-IR, AUCGln0-3 min, AUCIns0-10 min and HOMA-β between group A and group C (P＞0.05).There were no significant differences in FPG, HOMA-IR, AUCGln0-3 min, AUCIns0-10 min and HOMA-β between group B and group D (P＞0.05).After treatment, the FPG, HOMA-IR, AUCGln0-3 min, AUCIns0-10 minand HOMA-β of the patients in group B and group D were better than those in group A, and the differences were statistically significant (P＜0.05).After treatment, the FPG, HOMA-IR, AUCGln0-3 min, AUCIns0-10 min and HOMA-β of group D were better than those of group C, and the differences were statistically significant (P＜0.05).There were statistically significant differences in the clinical indicators of patients between group B and group C after treatment (P＜0.05).There was no statistically significant difference in the BMI of the four groups after treatment (P＞0.05).Conclusion Taoren Chengqi Decoction combined with Western medicine sequential therapy can effectively control the blood glucose levels of newly diagnosed type 2 diabetic patients, keep the blood glucose level stable, which has clinical promotion value. 2020 Vol. 27 (22): 12-15转19 [Abstract] ( 39 ) HTML (48 KB)  PDF  (0 KB)  ( 7 ) 16 Expression and clinical significance of blood neutrophil-to-lymphocyte ratio in colorectal cancer patients before surgery WU Yu-chen；WANG Sheng；ZHOU Yun；LIANG Zhong Objective To analyze the expression and clinical significance of blood neutrophil-to-lymphocyte ratio (NLR)in colorectal cancer patients before surgery.Methods A total of 230 patients with colorectal cancer admitted to Zhejiang Cancer Hospital from January to August 2019 were selected as the colorectal cancer group, and 161 healthy subjects during the same period were selected as the healthy control group.The blood NLR in each group was compared.At the same time, routine pathology of colorectal cancer patients was collected and the blood NLR of different pathological features was compared.Results The blood NLR of the colorectal cancer group was higher than that of the healthy control group, and the difference was statistically significant (P＜0.01).The blood NLR of patients with colorectal cancer of stage M1 was higher than that of stage M0, and the difference was statistically significant (P＜0.05).The blood NLR of colorectal cancer patients with the maximum tumor diameter ≥5 cm was higher than that of patients with the maximum tumor diameter ＜5 cm, and the difference was statistically significant (P＜0.01).There was no statistically significant difference in blood NLR of colorectal cancer patients with different occurrence locations,differentiation types, and morphological characteristics (P＞0.05).Conclusion Preoperative detection of blood NLR in patients with colorectal cancer is not only a surrogate marker for tumor related inflammatory status, it also provides information regarding tumor size and presence of distant metastasis, which has clinical implications on treatment planning and disease prognosis. 2020 Vol. 27 (22): 16-19 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 20 Progress of clinical application of continuous blood purification in acute kidney injury in critically ill patients WEI Yan-ping The body function of critically ill patients will have severe dysfunction, and the blood circulation function,nerve function and metabolic function of the patient will be affected to varying degrees, which will be prone to a variety of complications.Acute kidney injury is a common complication in critically ill patients.Patients′ kidney function will quickly appear dysfunction, resulting in patients being unable to excrete metabolites and toxic substances from the body, which seriously endangers the lives of patients.In the clinical treatment of patients with severe acute kidney injury, continuous blood purification is mainly used to replace kidney function, excrete metabolites and toxins in the body, and improve patients′ physical function.This article reviews the progress of clinical application of continuous blood purification in acute kidney injury in critically ill patients. 2020 Vol. 27 (22): 20-22转26 [Abstract] ( 40 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 23 Research progress of benefit and risk of Aspirin in patients with chronic obstructive pulmonary disease LI ping；WANG Chun-yan Aspirin, as a non-steroidal anti-inflammatory drug (NSAIDs) with a long history, has been widely used in clinic.Aspirin asthma (AIA) refers to taking aspirin or other NSAIDs within a few minutes or hours after the occurrence of symptoms such as nasal congestion asthma bronchospasm.In this paper, the benefits and risks of Aspirin in patients with chronic obstructive pulmonary disease were studied by referring to relevant literature, and the benefits and risks of Aspirin in chronic obstructive pulmonary disease patients with respiratory distress as the main characteristics were discussed, so as to provide reference for clinical application. 2020 Vol. 27 (22): 23-26 [Abstract] ( 44 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 27 Clinical effect of hormone at different doses combined with Cyclophosphamide pulse therapy in the treatment of membranous nephropathy CAO Shan；LIU Yu Objective To investigate the effect of hormone at different doses combined with Cyclophosphamide pulse therapy in the treatment membranous nephropathy.Methods Totally 32 patients with membranous nephropathy admitted into our hospital from January 2016 to June 2018 were selected.They were divided into two groups by a random number table, 16 cases in each group.Both groups received Cyclophosphamide pulse therapy.Based on that, the control group was given a sufficient dose of hormone [1 mg/(kg·d) Prednisolone acetate tablets], and the observation group was given a medium dose of hormone [0.5 mg/(kg·d) Prednisolone acetate tablets].The clinical efficacy, blood lipid indexes, the time of bone mineral density reduction, and adverse reactions were compared between the two groups.Results After treatment, the total remission rate and serum creatinine (Cr) level of the two groups had no significant differences (P＞0.05).After treatment, the total cholesterol (TC), triglycerides (TG) and low-density lipoprotein (LDL) levels were lower than those before treatment, and the levels of TC, TG, and LDL in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).The time of bone mineral density reduction in the observation group was later than that of the control group, and the total incidence of adverse reactions was lower than that of the control group, the differences were statistically significant (P＜0.05).Conclusion Combined with Cyclophosphamide pulse therapy, the adequate-dose hormone treatment and the medium-dose hormone treatment have equivalent effect on membranous nephropathy, but using medium-dose hormone treatment can effectively regulate blood lipid levels, delay the occurrence of osteoporosis, and reduce the incidence of adverse reactions. 2020 Vol. 27 (22): 27-29转33 [Abstract] ( 40 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 30 Application of red light irradiation in surgical incision of calcaneus fracture DONG Rui-yi；WU Yong-dong；WEI Jin-dong Objective To explore the clinical effect of red light irradiation applied to surgical incision of calcaneal fracture.Methods From January 2017 to January 2019, 90 patients with calcaneal fracture were selected as subjects and divided into observation group and control group according to the method of random number table,each with 45 cases.Both groups were treated with open reduction and internal fixation.The incisions in the observation group after operation were provided with red light irradiation besides conventional dressing changes, while in the control group, routine dressing change alone was carried.Both groups of patients were followed up for 3 months after surgery.The incision exudation and healing time of the two groups of patients were compared.On the second, fourth, and sixth days after surgery, the visual analogue scale (VAS) score was used to evaluate the incision pain of the two groups.The incidence of incision inflammation, skin margin necrosis, incision cracking, and incision infection with complications were compared.Results The incision exudation and healing time of the observation group were shorter than those in the control group, with statistically significant differences (P＜0.05).The VAS scores of patients on the second, fourth, and sixth days after operation in the observation group were lower than those of the control group,with statistically significant differences(P＜0.05).The incision inflammation rate and marginal necrosis rate in the observation group were lower than those of the control group, with statistically significant differences (P＜0.05).There was no statistically significant difference in incision cracking or incision infection with complications rate (P＞0.05).Conclusion The application of red light irradiation to the surgical incision of calcaneal fractures can shorten the time of exudation and healing, reduce the degree of pain,decrease the incidence of inflammatory reactions and necrosis of the skin margin,and has a great application value. 2020 Vol. 27 (22): 30-33 [Abstract] ( 41 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 34 Clinical study on the treatment of pneumoconiosis after lavage with oxygen atomization inhalation combined with non-invasive expectoration machine DAI Lian-ying；ZHAO Bin；FU Chun-sheng Objective To explore the effect of oxygen atomization inhalation combined with non-invasive expectoration machine in the treatment of pneumoconiosis.Methods The clinical data of 80 patients with pneumoconiosis who were treated with small volume lung lavage from June 2018 to December 2019 were analyzed retrospectively.According to the different treatment methods, they were divided into group A (40 cases) and group B (40 cases).Group A was treated with oxygen atomization inhalation combined with non-invasive expectoration machine, and group B with single oxygen atomization inhalation.The lung function, blood gas analysis index and clinical symptom score of the two groups were compared after 5 days of treatment.Results Carbon monoxide dispersion (DLCO), forced expiratory volume in 1 second(FEV1), total lung (TLC) levels in group A were (8.34±1.65) mmol/(min·kPa), (4.55±0.77) L, (8.71±2.12) L, higher than group B (DLCO: [7.24±2.82] mmol/(min·kPa), FEV1: [3.89±1.16] L, TLC: [7.52±1.67] L), the differences were statistically significant (P＜0.05).Blood oxygen saturation (SaO2), oxygen partial pressure (PaO2) levels in Group A were(96.12±3.15)%, (97.42±8.07) mmHg, higher than group B (SaO2: [93.17±5.68]%, PaO2: [91.37±6.64] mmHg), the differences were statistically significant (P＜0.05); the clinical symptom score of group A was (1.75±0.62) points, which was lower than that of group B ([2.56±1.01] points), the difference was statistically significant (P＜0.05).Conclusion The combination of oxygen atomization inhalation and non-invasive expectoration machine can reduce the clinical symptoms, improve the lung function and blood gas analysis index, improve the patients′ tolerance to lung lavage, and facilitate the early recovery. 2020 Vol. 27 (22): 34-36转40 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 37 Effect of Ginkgo Biloba Injection on the prognosis of patients with chronic obstructive pulmonary disease at acute exacerbation stage YAN Yu-sheng；TANG Yu-ling Objective To observe the effect of Ginkgo Biloba Injection on the prognosis of patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) stage and to explore its mechanism.Methods From November 2016 to November 2017, 60 patients with AECOPD in the department of respiratory medicine of our hospital were selected and divided into observation group and control group by random number method, each had 30 cases, control group accepted conventional symptomatic treatment (oxygen, spasmolysis, anti-infection, etc.), on the basis of conventional treatment, the observation group was supplemented with Ginkgo Biloba Injection (20 mg plus 0.9% sodium chloride injection 250 ml, intravenous infusion, once per day, course of treatment for 14 days).Therapeutic effect, C-reactive protein,D-dimer,whole blood viscosity(BV),plasma viscosity(PV),blood gas analysis(oxygen partial pressure[PO2],carbon dioxide partial pressure [PCO2])were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The C-reactive protein, D-dimer, BV, PV, and PCO2 of the observation group after treatment were lower than those of the control group,and PO2 was higher than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion Ginkgo Biloba Injection has a good effect on prognosis in the adjuvant the therapy of AECOPD stage. 2020 Vol. 27 (22): 37-40 [Abstract] ( 42 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 41 Effect of endoscopic metal titanium clip combined with Adrenaline injection treating ulcerative upper gastrointestinal hemorrhage and its effect on inflammatory factor levels in patients YANG Bo；ZHENG Li-mei；LI Jing；CHEN Liang-ren；CAI Fang-zhou；LIANG Yuan-guo Objective To explore the effect of endoscopic metal titanium clip combined with Adrenaline treating ulcerative upper gastrointestinal bleeding and its effect on the level of inflammatory factors in patients.Methods A total of 98 patients with ulcerative upper gastrointestinal bleeding admitted in our hospital from March 2018 to November 2019 were selected as the research subjects and divided into a control group and an observation group according to the lottery grouping method, each had 49 cases.The control group received conventional medical treatment, and the observation group received endoscopic metal titanium clips combined with Adrenaline injection.The hemostatic effect, inflammatory factor levels and adverse reactions were compared between the two groups of patients.Results The hemostatic success rate in the observation group (95.92%) was higher than that in the control group (79.59%), and the rebleeding rate (4.08%) was lower than that in the control group(20.41%), the differences were statistically significant(P＜0.05); the levels of interleukin-6, interleukin-8 and tumor necrosis factor- α in the observation group were lower than those in the control group after treatmentthe, the differences were statistically significant (P＜0.05); there was no significant difference in total incidence of adverse reactions between the two groups after treatment (P＞0.05).Conclusion Treatment of patients with ulcerative upper gastrointestinal bleeding with endoscopic metal titanium clips combined with Adrenaline therapy can improve hemostatic effect, improve inflammation and reduce adverse reactions. 2020 Vol. 27 (22): 41-43 [Abstract] ( 40 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 44 Clinical effect of Xuesaitong Injection combined with Atorvastatin Calcium in the treatment of diabetes with cerebral infarction ZENG Xiao-hua；HUANG Wen Objective To explore the clinical effect of Xuesaitong Injection combined with Atorvastatin Calcium in the treatment of diabetes with cerebral infarction.Methods A total of 120 patients with diabetes with cerebral infarction admitted to our hospital from January 2017 to January 2019 were selected as the research objects.They were divided into the control group (n=60) and the observation group (n=60) according to the random number table method.Patients in the control group were treated with Atorvastatin Calcium alone, and patients in the observation group were treated with Xuesaitong Injection combined with Atorvastatin Calcium.The National Institute of Health stroke scale (NIHSS)score, plasma viscosity, whole blood high shear viscosity, hematocrit before and after treatment, total effective rate of treatment and incidence of adverse reactions were compared between the two groups.Results There was no significant difference in NIHSS score between the two groups before treatment (P＞0.05).The NIHSS score of the observation group after treatment was lower than that of the control group, and the difference was statistically significant (P＜0.05).The total effective rate of treatment in the observation group was 93.33%, which was higher than 68.33% in the control group,with statistical significance (P＜0.05).There were no statistically significant differences in plasma viscosity, high blood viscosity and hematocrit before treatment between the two groups (P＞0.05).After treatment, the plasma viscosity, high blood viscosity and hematocrit in the observation group were lower than those in the control group, with statistical significances (P＜0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups (P＞0.05).Conclusion Combined treatment of Xuesaitong Injection and Atorvastatin Calcium in diabetic patients with cerebral infarction can effectively improve nerve function, enhance curative effect, improve blood viscosity, avoid adverse reactions, and increase safety. 2020 Vol. 27 (22): 44-47 [Abstract] ( 41 ) HTML (40 KB)  PDF  (0 KB)  ( 6 ) 48 Application effect of deep-slow abdominal respiratory and lip girdle expiration combined with artificial respiration training in elderly pneumoconiosis patients HUANG Xiao-yun；LIU Ning；JIANG Bing-zhen；LUO Heng-xiu Objective To explore the application effect of deep-slow abdominal respiratory and lip girdle expiration combined with artificial respiration training in elderly pneumoconiosis patients.Methods A total of 80 elderly pneumoconiosis patients treated from June 2010 to July 2019 in our department were reviewed.40 cases of taking deep-slow abdominal respiratory and lip girdle expiration were set as control group; 40 cases of taking deep-slow abdominal respiratory, lip girdle expiration and artificial respiration training were set as observation group.The forced vital capacity(FVC), forced expiratory volume in one second (FEV1), ratio of FEV1 to forced vital capacity (FEV1/FVC), maximal ventilatory volume (MVV) and ratio of residual volume to total lung capacity (RV/TLC), clinical symptom scores and quality of life (QOL) scores were compared.Results Before intervention, the values of FVC, FEV1, FEV1/FVC, MVV and RV/TLC between groups were not significantly different (P＞0.05); after intervention, the values of FVC, FEV1, FEV1/FVC and MVV of two groups were higher than those before intervention; RV/TLC value was lower than that before intervention, the differences were statistically significant (P＜0.05); after intervention, the values of FVC, FEV1, FEV1/FVC and MVV in the observation group were higher than those of control group, RV/TLC value was lower than that of control group, the differences were statistically significant (P ＜0.05).Before intervention, the symptom scores between groups were not significantly different (P＞0.05); after intervention, related scores in the observation group were lower than those of control group, the differences were statistically significant (P＜0.05).Before intervention,QOL scores between groups were not significantly different (P＞0.05); after intervention, QOL scores of two groups were higher than those before intervention, the differences were statistically significant (P＜0.05); after intervention, QOL scores in the observation group were higher than those of control group, the differences were statistically significant (P＜0.05).Conclusion The deep-slow abdominal respiratory and lip girdle expiration combined with artificial respiration training has obvious effect in elderly pneumoconiosis patients, which can relieve the clinical symptoms, and improve the pulmonary function and daily life. 2020 Vol. 27 (22): 48-51 [Abstract] ( 35 ) HTML (40 KB)  PDF  (0 KB)  ( 6 ) 52 Clinical effect of Salmeterol Fluticasone and low-dose Erythromycin in the treatment of bronchiectasis DING Shuang Objective To explore the clinical effect of Salmeterol Fluticasone + low-dose Erythromycin in the treatment of bronchiectasis.Methods A total of 120 patients with bronchiectasis admitted to our hospital from June 21, 2018 to June 21, 2019 were selected as the research objects, and they were randomly divided into two groups according to the single and double numbers, 60 cases in each group, and the control group was treated with Erythromycin, the observation group was treated with Salmeterol Fluticasone + low-dose Erythromycin, and then the forced vital capacity (FVC),peak expiratory flow rate (PEF), forced expiratory volume in one second (FEV1), cough sputum score, cough score,shortness of breath score, total incidence of adverse reactions, time of disappearance of sputum, time of disappearance of lung rales, and time of body temperature returning to normal were compared.Results The PEF ([4.76±0.37] L/s), FVC([2.76±0.41] L), FEV1([1.92±0.46] L) of the observation group after treatment were higher than those of the control group PEF ([3.49±0.42] L/s), FVC ([2.11±0.19] L), FEV1 ([1.45±0.11] L), the differences were statistically significant (P＜0.05).The observation group′s shortness of breath score ([0.37±0.08] points), expectoration score ([0.44±0.19] points), cough score ([0.62±0.19] points), the total incidence of adverse reactions (3.33%) were lower than those of the control group for shortness of breath score ([1.54±0.27] points), expectoration score ([1.65±0.28] points), cough score ([1.43±0.28]points), total incidence of adverse reactions (26.67%), the differences were statistically significant (P＜0.05), the time of disappearance of lung rales in the observation group ([3.16±0.52] d), the time of disappearance of sputum ([1.26±0.68]d), the time of body temperature returning to normal ([2.27±1.54] d) were all shorter than those of the control which the disappearance time of lung rales [(4.87±1.55) d], the disappearance time of sputum ([3.68±1.53] d) and the time of body temperature returning to normal ([4.61±1.27] d), the differences were statistically significant (P＜0.05).Conclusion Salmeterol Fluticasone plus low-dose Erythromycin in patients with bronchiectasis has a significant effect, which can reduce the incidence of adverse reactions. 2020 Vol. 27 (22): 52-54转58 [Abstract] ( 37 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 55 Effect of Xiongdan Shugan Lidan Capsules on liver function in patients with acute viral hepatitis GUO Zhen-ke；LIU Yu-hu；ZHONG Can-xin Objective To explore the effect of Xiongdan Shugan Lidan Capsules on the liver function of patients with acute viral hepatitis.Methods A total of 92 patients with acute viral hepatitis admitted to our hospital from August 2016 to December 2018 were selected as subjects, 46 cases in each group.They were divided into control group and observation group according to the random number table method.Patients in the control group were given Western medicine for liver protection.Patients in the observation group were treated with Xiongdan Shugan Lidan Capsules on the basis of the control group, and the treatment time was 4 weeks.The clinical efficacy, adverse reactions, liver function and blood lipid levels before and after treatment of the two groups of patients were compared and analyzed.Results The total effective rate of patients in the observation group after treatment was 97.83%, which was higher than 78.26% of the control group, the difference was statistically significant (P＜0.05).After treatment, the levels of glutamine transpeptidase (GGT), aspartame, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBil) were lower than those of the control group, the differences were statistically significant (P＜0.05).The levels of low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) in the observation group were higher than those in the control group, the level of triacylglycerol (TG) was lower than that in the control group, and the differences were statistically significant (P＜0.05).No adverse reactions occurred during the treatment of the two groups of patients, and the safety was high.Conclusion The application of Xiongdan Shugan Lidan Capsules in the treatment of patients with acute viral hepatitis has obvious effect, can significantly improve the liver function and blood lipid levels of patients, and has high safety, which is worthy of popularization and application in clinic. 2020 Vol. 27 (22): 55-58 [Abstract] ( 62 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 59 Clinical effect of catheter thrombolysis combined with pressure thrombolysis via dorsalis pedis artery of foot and superficial vein of the affected limb in the treatment of lower extremity deep vein thrombosis TANG Zeng-yao；MEI Han-ying；LIU Ju；LIU Ji-wen Objective To explore the clinical effect of catheter thrombolysis combined with pressure thrombolysis via dorsalis pedis artery of foot and superficial vein of the affected limb in the treatment of lower extremity deep vein thrombosis (DVT).Methods From February 2016 to May 2018, 100 patients with DVT admitted to our hospital were selected and divided into the observation group (n=50) and the control group (n=50) according to the order of admission.The control group was treated with dorsalis pedis vein combined with lower extremity venous compression thrombolysis,the observation group was treated with catheter thrombolysis combined with pressure thrombolysis via dorsalis pedis artery and superficial vein of the affected limb.The peripheral diameter difference of thigh and calf(20 cm above and 15 cm below the patella), the changes of D-Dimer (D-D), clinical treatment effect and complications of the two groups were observed.Results After treatment, the differences of peripheral diameter of thigh and leg in the observation group were lower than those in the control group, with statistical significance (P＜0.05).The peak of D-D concentration in the observation group appeared on the first day of the treatment, the peak of D-D concentration in the control group appeared on the third day.The concentrations of D-D in the observation group on the 3rd, 5th and 7th days were lower than those in the control group, with statistical significances (P＜0.05).The total effective rate in the observation group was 98.00%, which was higher than that in the control group (80.0%), the difference was statistically significant (P＜0.05).The total incidence of complications in the observation group was 4.00%, which was lower than that in the control group (16.00%), the difference was statistically significant (P ＜0.05).Conclusion Catheter thrombolysis combined with pressure thrombolysis via dorsalis pedis artery and superficial vein of the affected limb has obvious effect and high clinical value. 2020 Vol. 27 (22): 59-61转65 [Abstract] ( 38 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 62 Clinical effect of valgus carotid endarterectomy in the treatment of carotid stenosis YANG Pu-gen；OUYANG Liang-yuan；LIU Jun；SHEN Bo；WU Jing Objective To investigate the clinical application effect of valgus carotid endarterectomy in the treatment of carotid stenosis.Methods A total of 50 patients with carotid stenosis who were admitted to our hospital from September 2014 to August 2019 were selected as the research subjects.According to the random number table method, they were divided into the control group (25 cases) and the observation group (25 cases).The control group was given classic carotid endarterectomy, and the observation group was given valgus carotid endarterectomy.The duration of surgery,length of hospital stay, postoperative complications, and clinical efficacy were compared between the two groups.Results The duration of surgery and the length of hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant(P＜0.05).The plaque area in the observation group was smaller than that in the control group, and the intima-media thickness (IMT) in the observation group was thicker than that in the control group, the differences were statistically significant (P＜0.05).Conclusion The clinical application effect of valgus carotid endarterectomy in the treatment of carotid stenosis is favorable, which can shorten the duration of surgery and the length of stay, reduce the incidence of postoperative complications, and has a higher application value. 2020 Vol. 27 (22): 62-65 [Abstract] ( 38 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 66 Influence of Xinkeshu Tablets on anxiety and life quality after percutaneous coronary intervention for coronary heart disease patients HOU Ying-wei Objective To explore the influence of Xinkeshu Tablets on anxiety and life quality after percutaneous coronary intervention (PCI) for coronary heart disease patients.Methods A total of 82 patients with coronary heart disease who underwent PCI in our hospital from January 2018 to January 2019 were selected as the research objects, according to random number table methods, all patients were divided into the routine group (41 cases) and the test group (41 cases).Patients in the routine group were treated with routine therapy, while patients in the test group were treated with routine therapy and Xinkeshu Tablets.Both groups were treated for 12 weeks.The scores of self-rating anxiety scale(SAS) before medication, 4 weeks after medication and 12 weeks after medication were compared between the two groups, and the quality of life scores of the two groups before and after 12 weeks of medication were observed.Results After 4 weeks and 12 weeks of medication, the SAS scores in the test group were lower than those in the routine group(P＜0.05).After 12 weeks of medication, the scores of social competence, physiological function, mental health, physiological competence, motivation of life, role emotional, bodily pain and overall scores in the test group were higher than those in the routine group (P＜0.05).Conclusion The application of Xinkeshu Tablets in patients with coronary heart disease undergoing PCI can improve their anxiety level, improve their quality of life, and play a certain clinical application effect. 2020 Vol. 27 (22): 66-68转72 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 69 Effect of low-dose Milrinone in the treatment of chronic heart failure patients over 80 years old TANG Ai；YANG Gui-zhi Objective To observe the effect of low-dose Milrinone in the treatment of chronic heart failure (CHF) patients over 80 years old.Methods A total of 60 patients over 80 years old with CHF were selected and divided into the treatment group and the control group by random number table method, 30 cases in each group.The treatment group was treated with standard treatment combined with low-dose Milrinone, and the control group was treated with standard treatment.The total effective rate, blood pressure, heart rate, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular end systolic volume(LVESV), left ventricular end diastolic volume (LVEDV) and 6-minute walking test distance were compared between the two groups.Results The total effective rate was 86.7% in the treatment group, which was significantly higher than that in the control group (53.3%), the difference was statistically significant (P＜0.01).The LVEF ([57.2±9.3]%) and 6-minute walking test distance [(499.5±50.2) m] in the treatment group were higher than those in the control group([45.7±8.8]% and [392.5±90.8] m), the differences were statistically significant (P＜0.01).The LVESV ([116.3±52.7]ml),LVEDV ([192.6±45.4] ml) and LVESD ([47.4±6.3] mm) in the treatment group were lower than those in the control group ([126.2±41.5] ml, [201.9±50.2] ml and [50.2±8.6] mm), with statistical significances (P＜0.05).The LVEDD in the treatment group was (60.6±10.1) mm, which in the control group was (61.2±10.8) mm, with no statistical significance(P＞0.05).The LVEF ([57.2±9.3]%), 6-minute walking test distance ([499.5±50.2] m) in the treatment group after treatment were higher than those before treatment ([37.3±11.4]%, [246.6±72.2] m), the differences were statistically significant (P＜0.01).The LVESD, LVEDD, LVEDV and LVESV in the treatment group after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05).The LVEF and 6-minute walking test distance of the control group after treatment were higher than those before treatment, the differences were statistically significant(P＜0.05).There were no significant differences in LVESV, LVEDV, LVESD and LVEDD between the control group before and after treatment (P＞0.05).There were no significant differences in blood pressure and heart rate between the two groups before and after treatment (P＞0.05).Conclusion The low-dose Milrinone can significantly improve heart function and exercise tolerance in elderly patients over 80 years old. 2020 Vol. 27 (22): 69-72 [Abstract] ( 42 ) HTML (34 KB)  PDF  (0 KB)  ( 5 ) 73 Clinical effect of Salvia Miltiorrhizae and Ligustrazine Injection treating cerebral thrombosis ZHANG Min Objective To explore the clinical effect of Salvia Miltiorrhizae and Ligustrazine Injection treating cerebral thrombosis.Methods A total of 114 patients with cerebral thrombosis admitted to our hospital from June 2017 to June 2019 were selected as the research subjects.They were divided into control group and observation group according to the random number table method, 57 cases in each group.The control group was treated with conventional western medicine.The observation group was treated with Salvia Miltiorrhizae and Ligustrazine Injection.The traditional Chinese medicine (TCM) syndrome scores before and after treatment, total effective rate of treatment, and superoxide dismutase (SOD), malondialdehyde (MDA), lysophosphatidic acid (LPA), and endothelin (ET) before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group (98.25%)was higher than that in the control group (84.21%), and the difference was statistically significant (P＜0.05).TCM syndrome score in the observation group ([8.53±1.24] points) after treatment was lower than that in the control group([12.76±1.61] points), the difference was statistically significant (P＜0.05).After treatment, the SOD content of patients in the observation group ([107.64±14.54] U/ml) was higher than that in the control group ([88.96±12.36] U/ml), MDA([5.56±0.72] μmol/L), LPA ([1.70±0.25] μmol/L), ET ([84.62±6.84] ng/L) content were lower than those in the control group ([7.89±0.94] μmol/L, [2.53±0.33] μmol/L, [120.64±10.51] ng/L), the differences were statistically significant (P＜0.05).Conclusion On the basis of conventional Western medicine treatment for patients with cerebral thrombosis, the treatment with Salvia Miltiorrhizae and Ligustrazine Injection can effectively regulate the patients′ oxidative stress response, and its application effect is significant and worthy of promotion. 2020 Vol. 27 (22): 73-75 [Abstract] ( 41 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 76 Influence of mindfulness-based cognitive therapy on the rehabilitation effect of trouble-making schizophrenia patients WANG Yun-fang；LI Ri-zhao；WANG Mei；TAN Feng-ling；OUYANG Xiao-fen；XU Qu Objective To study the value of mindfulness-based cognitive therapy in the rehabilitation of trouble-making schizophrenia patients.Methods A total of 104 trouble-making schizophrenia patients admitted to Compulsory Medical Institute of Guangzhou Civil Affairs Bureau Mental Hospital from August 2017 to March 2019 were selected as the research objects, and they were divided into the control group and the study group according to the random doubleblind method, 52 cases in each group.Patients in the control group received the routine nursing, and patients in the study group received the mindfulness-based cognitive therapy on the basis of the control group.The positive and negative symptom scale (PANSS), five-facet mindfulness questionnaire (FFMQ), and nurses′ observation scale inpatient evaluation (NOSIE) scores before and after intervention between the two groups were compared.Results There were no statistically significant differences in the scores of PANSS before intervention between the two groups (P＞0.05).The PANSS scores of patients of the two groups after intervention were lower than those before intervention, and the PANSS scores of the study group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05).There was no significant difference in the FFMQ score of patients between the two groups before intervention (P＞0.05).The FFMQ scores of patients of the two groups after intervention were higher than those before intervention, and the FFMQ score of patients of the study group after intervention was higher than that of the control group, the differences were statistically significant (P＜0.05).There were no statistically significant differences in the total positive factors, total negative factors, and the total estimated scores of patients between the two groups before intervention (P＞0.05).The NOSIE scores of patients of the two groups after intervention were lower than those before intervention, and the NOSIE scores of patients of the study group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05).Conclusion The scientific and standardized mindfulness-based cognitive therapy by evidence-based methods in the rehabilitation of trouble-making schizophrenia patients can improve depression and relieve pain.It is worthy of clinical promotion and application. 2020 Vol. 27 (22): 76-79转86 [Abstract] ( 39 ) HTML (42 KB)  PDF  (0 KB)  ( 7 ) 80 Application of quality control circle activities in interventional therapy for patients with liver cancer WEN Xiao-juan；ZHU Zhi-mei  Objective To explore the application and effect of quality control circle activities in interventional therapy for patients with liver cancer.Methods A total of 78 patients undergoing interventional treatment for liver cancer in our hospital from January 2017 to January 2019 were selected as the research objects, and were divided into a control group (n=39) and an observation group (n=39) according to the order of admission.The control group adopted routine nursing intervention, and the observation group adopted nursing intervention under quality control circle activities.The total nursing satisfaction, total postoperative complication rate and disease knowledge understanding of the two groups were compared.Results The total nursing satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The disease knowledge understanding score in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of quality control circle activities in the nursing of patients with interventional surgery for liver cancer can improve patients′ cognition of the disease, reduce the incidence of postoperative complications, and optimize patients′ satisfaction with nursing, which is worthy of promotion. 2020 Vol. 27 (22): 80-82 [Abstract] ( 33 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 83 Application of Trastuzumab combined with chemotherapy in patients with breast cancer who underwent modified radical mastectomy and postoperative chemotherapy GONG Yu-ai；SHU Cheng-rong；HAN Qi Objective To explore the application of Trastuzumab combined with chemotherapy in patients with breast cancer who underwent modified radical mastectomy and postoperative chemotherapy.Methods A total of 81 patients with newly treated breast cancer who underwent modified radical mastectomy and postoperative chemotherapy in our hospital from January 2015 to January 2017 were selected as research subjects.They were divided into a control group(n=40) and a study group (n=41) according to random number table method.The control group was treated with Docetaxel + Carboplatin method, and the study group was treated with combination of Trastuzumab and chemotherapy.The tumor load and immunity function of the two groups were compared.Results The levels of serum tumor markers including carcinoembryonic antigen (CEA), carbohydrate antigen (CA)199, CA153, and CA125 in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05).The levels of serum tumor active molecules like vascular endothelial growth factor (VEGF), nectin-4, thymidine kinase-1 (TK-1), platelet factor 4(PF-4), and tumor specific growth factor (TSGF) in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05).The ratio of serum CD3+, CD4+ lymphocyte, and CD4+/CD8+ in the study group were higher than those in the control group, and the ratio of CD8+ lymphocyte was lower than that in the control group, the differences were statistically significant (P ＜0.05).Conclusion The use of Trastuzumab combined with chemotherapy after improved radical mastectomy for breast cancer can reduce the tumor of breast cancer patients and improve their immune response, which has clinical application value. 2020 Vol. 27 (22): 83-86 [Abstract] ( 40 ) HTML (39 KB)  PDF  (0 KB)  ( 5 ) 87 Clinical effect of drug-loaded microspheres transcatheter arterial chemoembolization treating large liver cancer ZHOU Zhao-hai；ZHOU Jian-hui；LIU Hong-jun Objective To investigate the clinical effect of drug-loaded microspheres transcatheter arterial chemoembolization (DEB-TACE) treating large liver cancer.Methods A retrospective analysis of 73 cases of large liver cancer patients undergoing transarterial arterial chemoembolization admitted to our hospital from January 2017 to January 2019,including 35 cases of drug-loaded microsphere hepatic arterial chemoembolization (DEB-TACE) (observation group),38 cases of traditional hepatic arterial chemoembolization (c-TACE) (control group), laboratory tests were performed before treatment and on days 3 and 7 after treatment, and intensive CT examination was performed before treatment and 1 month after treatment.The imaging data and clinical data were analyzed and summarized to compare the differences in the incidence of tumor response, complications and adverse reactions between the two treatment methods in patients.Results The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of patients of the two groups on the 3rd and 7th days after treatment were higher than those in this group before treatment,and the differences were statistically significant(P＜0.05).There were no significant differences in ALT and AST between the two groups on the 3rd and 7th days after treatment (P＞0.05).There were no serious adverse reactions in both groups; there were no significant differences in the disease remission rate and disease control rate at 1 month after treatment between two groups (P＞0.05).Conclusion DEB-TACE is safe and effective in the treatment of large liver cancer, and it is worthy of clinical application. 2020 Vol. 27 (22): 87-90 [Abstract] ( 32 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 91 Application effect of Huachansu Tablets in chemotherapy for postoperative patients with colorectal cancer WANG Ming-wei Objective To explore the application effect of Huachansu Tablets in chemotherapy for postoperative patients with colorectal cancer.Methods A total of 122 cases of postoperative patients with colorectal cancer treated in our hospital from January 2018 to January 2019 were selected as the research objects.They were divided into study group (Huachansu Tablets combined with XELOX regimen treatment) and control group (XELOX regimen treatment), 61 cases in each group.The quality of life (KPS) scores, carcinoembryonic antigen (CEA) levels before and after treatment,and the incidence of adverse reactions of patients were compared between the two groups.Results There was no significant difference in KPS score between the two groups before treatment (t=0.097, P＞0.05).After treatment, the KPS score of the study group was (82.64±6.47) points, which was higher than that of the control group of (76.41±5.47)points, the difference was statistically significant (t=5.743, P＜0.05).The CEA levels of the two groups before treatment had no statistically significant difference (t=0.043, P＞0.05), and the CEA of the study group after treatment was (2.78±0.66 ) μg/ml, which was lower than that of the control group of (3.97±1.33) μg/ml, the difference was statistically significant (t=6.260, P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The treatment of colorectal cancer patients undergoing chemotherapy with Huachansu Tablets combined with XELOX regimen can improve the quality of life and chemotherapy effect of patients, reduce adverse reactions, and have high clinical application value. 2020 Vol. 27 (22): 91-93 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 94 Diagnostic value of combined detection of serum alpha-fetoprotein, alphafetoprotein heterogeneity-L3, des-gamma-carboxyprothrombin, squamous cell carcinoma antigen in hepatocellular carcinoma LI Wei-wei Objective To explore the diagnostic value of combined detection of serum alpha-fetoprotein (AFP), alphafetoprotein heterogeneity-L3 (AFP-L3), des-gamma-carboxyprothrombin (DCP), squamous cell carcinoma antigen (SCCA) in hepatocellular carcinoma (HCC).Methods From May 2017 to May 2019, 40 patients with HCC, 42 patients with liver cirrhosis (LC), 54 patients with chronic hepatitis B (CHB), and 50 healthy people were selected from our hospital for serological indicators and clinical data.The levels of serum AFP, AFP-L3, DCP and SCCA were measured in each group, and the area under the curve of receiver operating characteristic (ROC) of 4 serum markers, alone or in combination, were compared.Results The levels of AFP, AFP-L3, DCP and SCCA in HCC group, LC group and CHB group were higher than those in the healthy group, the differences were statistically significant (P＜0.01).The levels of AFP, AFP-L3, DCP and SCCA in HCC group were higher than those in LC group and CHB group, the differences were statistically significant (P＜0.01).The area under ROC curve of the combined detection were all higher than those of four individual detections.Conclusion The combined detection of AFP, AFP-L3, DCP, and SCCA has a high detection efficiency, and provide a reliable reference for the early diagnosis of HCC. 2020 Vol. 27 (22): 94-96转100 [Abstract] ( 39 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 97 Diagnostic value of transvaginal color Doppler ultrasonography combined with plasma tumor markers detection in endometrial carcinoma SU Xiu-hong Objective To investigate the diagnostic value of transvaginal color Doppler ultrasonography combined with plasma tumor markers detection in endometrial carcinoma.Methods A total of 130 patients suspected with endometrial cancer admitted to our hospital from June 2017 to October 2019 were selected as study subjects.The patients were tested for the plasma tumor markers detection and transvaginal color Doppler ultrasonography detection.The gold standard was pathological diagnosis.The diagnostic value of transvaginal color Doppler ultrasonography combined with plasma tumor markers in endometrial carcinoma was analyzed.Results The results of transvaginal color Doppler ultrasonography showed that the uterus of the patient was enlarged, the endometrial thickness increased and there was local infiltration, the lesions were located in the endometrium and had uneven echoes.The results of transvaginal color Doppler ultrasonography were true positive in 65 cases and true negative in 14 cases.Plasma tumor markers were true positive in 34 cases and true negative in 5 cases.The sensitivity, specificity and accuracy of transvaginal color Doppler ultrasound combined with plasma tumor markers detection were all higher than those of transvaginal color Doppler ultrasound and plasma tumor markers detection, and the differences were statistically significant (P＜0.05).The sensitivity, specificity and accuracy of transvaginal color Doppler ultrasound were all higher than those of plasma tumor markers, and the differences were statistically significant (P＜0.05).Conclusion Transvaginal color Doppler ultrasonography combined with plasma tumor markers is more accurate in the diagnosis of endometrial cancer, the sensitivity and specificity are both higher and it is worthy of clinical application. 2020 Vol. 27 (22): 97-100 [Abstract] ( 35 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 101 Clinical effect of acupoint injection of Rat Nerve Growth Factor combined with conventional rehabilitation treating children with cerebral palsy HUANG Zhi-feng Objective To explore clinical effect of acupoint injection of Rat Nerve Growth Factor combined with conventional rehabilitation treating children with cerebral palsy.Methods Sixty children with cerebral palsy admitted to our hospital from October 2016 to May 2019 were selected as the research objects, and they were divided into a control group (30 cases) and an observation group (30 cases) according to the random number table method.The children in the control group were treated with conventional rehabilitation training.The observation group was treated with acupoint injection of Rat Nerve Growth Factor on the basis of the control group.The clinical efficacy, motor function and speech function of the two groups were compared.Results The total efficiency of the observation group after treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05).The gross motor function assessment table (GMFM88) score of the observation group after treatment was higher than that of the control group,and the difference was statistically significant (P＜0.05).After treatment, the language development retardation (S-S)score of the observation group was higher than that of the control group, and the difference was statistically significant(P＜0.05).Conclusion Acupoint injection of Rat Nerve Growth Factor combined with conventional rehabilitation has significant effect treating children with cerebral palsy, and can promote the development of motor function and speech function in children. 2020 Vol. 27 (22): 101-103 [Abstract] ( 36 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 104 Application effect of three-dose regimen of Ergometrine Maleate in repregnant women with scarred uterus ZHANG Ji-hong；LUO Xu-qing；DONG Chun-yan Objective To investigate the application effect of three-dose regimen of Ergometrine Maleate in re-pregnant women with scarred uterus.Methods A total of 146 re-pregnant women with scarred uterus (singleton pregnancy,full-term, cesarean section) treated in our hospital from October 2016 to October 2018 were selected as research subjects.They were divided into the control group (n=73) and the observation group (n=73) by the random number table method.The control group received continuous intravenous infusion of Oxytocin, and the observation group received three-dose regimen of Ergometrine Maleate.The biochemical indicators, labor stage, clinical efficacy, postpartum hemorrhage and adverse reactions of the two groups were compared.Results The hemoglobin levels after surgery of the two groups were lower than those before surgery, and the differences were statistically significant (P＜0.05).The hemoglobin level after surgery in the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The third stage of labor and postoperative hospital stay in the observation group were shorter than those in the control group, the total effective rate of treatment was higher than that in the control group, the intraoperative blood loss, 2 h postpartum hemorrhage, and 24 h postpartum hemorrhage were less than those in the control group,and the total incidence of adverse reactions was lower than that in the control group, the differences were statistically significant (P＜0.05).Conclusion The three-dose regimen of Ergometrine Maleate can shorten the labor stage of repregnant women with scarred uterus and reduce bleeding, with favorable therapeutic effect and high safety. 2020 Vol. 27 (22): 104-106转110 [Abstract] ( 36 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 107 Application effect of free drug distribution combined with medical and educational model in children with attention deficit hyperactivity disorder HUANG Yan-ke；WANG Lu；XIE Yu-fang；WU Si-han Objective To investigate the effect of the combination of free drug delivery and medical education on the awareness of drug compliance and disease knowledge in children with attention deficit hyperactivity disorder (ADHD).Methods From January 2018 to November 2019, a total of 100 ADHD children (100 parents and 50 teachers) who were treated in our hospital were selected.They were divided into observation group and control group according to the random number table method, 50 cases of children, 50 parents and 25 teachers in each group.The children in the control group were given outpatient routine treatment and free drug distribution (free for 2 months), and the children in the observation group were given medical and educational combination mode intervention on the basis of the children in the control group.The compliance of the medication of two groups of children, and before and after the intervention, the mastery of disease knowledge of two groups of children′s parents and teachers were compared.Results After 2 months of intervention, the scores of the knowledge of the incidence factors, the knowledge of treatment, and the knowledge of clinical symptoms of the two groups of parents and teachers were higher than those before the intervention, and those of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).The compliance of the observation group was higher than that of the control group, and the difference was statistically significant(P＜0.05).Conclusion The intervention of free drug distribution combined with medical education in children with ADHD has significant effect, which can improve the compliance of children, improve disease knowledge awareness rate of their parents and teachers,and help to promote children′s physical recovery,which is worthy of clinical application. 2020 Vol. 27 (22): 107-110 [Abstract] ( 41 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 111 Effect of acupuncture combined with Chinese medicine treating simple obesity in children ZHANG Min；CHEN Jin-hua；XU Jin-hua；YUE Yi-huan；WANG Qiong-yu Objective To investigate the effect of acupuncture and moxibustion combined with Chinese medicine treating simple obesity in children.Methods From January 2018 to January 2019, a total of 100 cases of children with simple obesity were selected as research objects, according to the computer random method, they were divided into the experimental group (50 cases) and the control group (50 cases).The experimental group used comprehensive treatment of the combination of acupuncture and moxibustion and Chinese medicine, the control group used traditional Chinese medicine acupuncture and moxibustion treatment.Both groups were treated for 2 courses (2 months), and the differences in biochemical indexes, body mass index (BMI), and serum leptin levels were compared between the two groups.Results There were no significant differences in the levels of high-density lipoprotein (HDL), total cholesterol (TC) and fasting blood glucose (FBG) between the two groups after treatment (P＞0.05).The levels of low-density lipoprotein(LDL), triglyceride (TG) and insulin (FINS) in the experimental group were lower than those in the control group, with statistically significant differences (P＜0.05).The BMI and serum leptin level of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05).The BMI and serum leptin level in the experimental group after treatment were lower than those in the control group, with statistically significant differences (P＜0.05).The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The comprehensive treatment of Chinese medicine can effectively reduce the level of serum leptin, BMI, FINS, blood lipid and so on in children with simple obesity. 2020 Vol. 27 (22): 111-113转117 [Abstract] ( 59 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 114 Application effect of Diazepam combined with Racemic Anisodamine Hydrochloride in the elimination of cervical edema during the delivery of primipara XIE Ting；LI Fei；LIU Man-ying；HUANG Wei-lan；CHEN Yin-feng Objective To explore the effect of Diazepam combined with Racemic Anisodamine Hydrochloride in the elimination of cervical edema during the delivery of primipara.Methods A total of 140 primiparas of vaginal trial labor who were admitted to our hospital from January 2017 to January 2020 were selected as the research objects, and were divided into study group (70 cases) and control group (70 cases) according to the random number table method.The study group was given intravenous injection of Diazepam combined with Racemic Anisodamine Hydrochlo, and the control group was given intravenous injection of Diazepam alone.The time from medication to opening of the uterus,total labor stage, postpartum hemorrhage, cesarean section rate, neonatal asphyxia, disappearance rate of cervical edema and adverse reaction rate of the two groups were recorded.Results The time from medication to opening of the uterus in the study group was (188.32±29.83) min, which was shorter than that in the control group of (246.28±30.24)min, the difference was statistically significant (P＜0.05).The total labor stage in the study group was (313.62±31.82)min, which was shorter than that in the control group of (372.28±33.28) min, the difference was statistically significant(P＜0.05).The postpartum hemorrhage of the study group was (182.37±48.39) ml, less than that in the control group of(233.29±50.28)ml,the difference was statistically significant (P＜0.05).The maternal cesarean section rate in the study group was 4.29%, lower than that in the control group (15.71%), the difference was statistically significant (P＜0.05).The disappearance rate of maternal cervical edema in the study group was 97.14%, high than that in the control group of 82.86%, the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Diazepam combined with Racemic Anisodamine Hydrochloride can effectively eliminate cervical edema in the perinatal period of perinatal women, it could shorten the full opening time of the uterus, shorten the labor process, relieve cervical spasm, reduce postpartum hemorrhage, reduce cesarean section rate, and improve maternal and infant outcomes, worthy of clinical application. 2020 Vol. 27 (22): 114-117 [Abstract] ( 46 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 118 Clinical effect of comprehensive therapy for postpartum hemorrhage after cesarean section XU Fang Objective To explore the clinical effect of comprehensive therapy on postpartum hemorrhage after cesarean section.Methods A total of 60 patients with postpartum hemorrhage after cesarean section who were admitted to our hospital from January 2018 to January 2019 were selected as the research subjects.According to the random comprehensive balance method, the patients were divided into the control group (30 cases) and the observation group (30 cases).The control group was given bilateral uterine artery ascending branch ligation, and the observation group was given comprehensive therapy, that was, uterine bunding combined with myometrial injection of Ergometrine for treatment.Hemodynamic indices, postpartum complications, surgical indices, and total effective rate of hemostasis were compared between the two groups.Results The hemodynamic indices were better than those in the control group, total effective rate of hemostasis in the observation group was higher than that in the control group, and the differences were statistically significant (P＜0.05).The total incidence rate postpartum complications and puerperal infection rate in the observation group were lower than those in the control group, the surgery time in the observation group was shorter than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion The effect of comprehensive therapy, namely uterine bunding combined with myometrial injection of Ergometrine in the patients with postpartum hemorrhage after cesarean section, is highly significant. 2020 Vol. 27 (22): 118-120 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 121 Clinical efficacy observation of Recombinant Interferon α2b for aerosol inhalation in the treatment of bronchiolitis in children LI De-you；XU Jing-huai；LIU Ming-feng Objective To investigate the clinical effect of Recombinant Interferon α2b for aerosol inhalation in the treatment of bronchiolitis in children.Methods A total of 80 cases of children with bronchiolitis treated in our hospital from October 2019 to January 2020 were selected as the research objects.According to the principle of random control,they were divided into the control group and the observation group, 40 cases in each group.The control group was given Budesonide + Terbutaline Atomization treatment, and the observation group was given Recombinant Interferon α2b for aerosol inhalation treatment on the basis of the control group.The clinical efficacy, the disappearance time of related symptoms, hospitalization time and hospitalization expenses were compared between the two groups.Results The total effective rate of the observation group was 100.00%, which was higher than 85.00% of the control group, there was significant difference (P＜0.05).The disappearance time of fever, cough, panting, wheezing rale, moist rale of the observation group were shorter than those of the control group, and the differences were significant (P＜0.05).The hospitalization time of the observation group was shorter than that of the control group, and the hospitalization cost of the observation group was lower than that of the control group, and the differences were significant (P＜0.05).Conclusion Recombinant interferon α2b for aerosol inhalation has a good clinical effect in the treatment of bronchiolitis in children, which can improve the clinical symptoms of children and shorten the disappearance time of symptoms in children. 2020 Vol. 27 (22): 121-123 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 124 Application of improved hematocele pad in vaginal delivery TANG Qiu-xia；LIU Chun-mei Objective To investigate the application of improved hematocele pad in vaginal delivery.Methods A total of 120 pregnant women with vaginal delivery who were admitted to our hospital from January to December 2019 were selected as the research subjects.All pregnant women were divided into the control group and the research group according to the time sequence of delivery, with 60 cases in each group.The control group was given general nursing pad to measure the bleeding volume, and the research group was given improved hematocele pad to measure the bleeding volume.The accuracy of measurement of bleeding volume on delivery, side leakage rate of blood, occupational exposure rate of medical staff, satisfaction of pregnant women and medical staff were compared between the two groups.Results The accuracy of measurement of bleeding volume on delivery in the research group was higher than that in the control group, and the incidence of side leakage of blood and occupational exposure of medical staff in the research group was lower than that in the control group, and the differences were statistically significant (P＜0.05).The satisfaction of pregnant women and medical staff in research group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Improved hematocele pad in vaginal delivery can accurately measure the bleeding volume on delivery, effectively reduce the incidence of side leakage of blood and occupational exposure of medical staff, guarantee the safety of pregnant women and medical staff, and improve the satisfaction of medical staff and pregnant women. 2020 Vol. 27 (22): 124-126转130 [Abstract] ( 36 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 127 Application of delivery ball + free position midwifery in primiparas and its influence on delivery mode GUI Yue-e；YANG Hong-zhi Objective To explore the application of delivery ball + free position midwifery in primiparas and its influence on delivery mode.Methods Seventy-three primiparas treated in our hospital were selected as research subjects from November 2018 to October 2019, and were divided into group A (n=36, traditional delivery intervention) and group B (n=37, delivery ball + freedom postural midwifery) according to the random number table method.The mode of delivery, first, second and third stages of labor, total complication incidence and pain in the two groups of primiparas were compared.Results The mode of delivery of group B was better than that of group A, the difference was statistically significant (P＜0.05).The first, second and third stages of labor of group B were shorter than those of group A, the differences were statistically significant (P＜0.05).The total incidence of maternal complications in group B was lower than that in group A, the difference was statistically significant (P＜0.05).The maternal pain in group B was lighter than that in group A, the difference was statistically significant (P＜0.05).Conclusion The application of the delivery ball combined with free position midwifery has a significant effect, which can effectively shorten the total delivery period of the primiparas, reduce the total incidence of complications, and reduce the pain of the mother.It is worthy of clinical promotion. 2020 Vol. 27 (22): 127-130 [Abstract] ( 35 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 131 Effect of Levothyroxine Sodium on thyroid function and maternal and neonatal outcomes in pregnant women with hypothyroidism HONG Hai-man Objective To discuss the effect of Levothyroxine Sodium on thyroid function and maternal and neonatal outcomes in pregnant women with hypothyroidism.Methods A total of 86 pregnant women with hypothyroidism treated in our hospital from January 2018 to January 2020 were selected as subjects and were divided into study group (43 cases)and routine group (43 cases) according to random number table method.The routine group took the conventional living guidance; on the basis of the former, the study group took Levothyroxine Sodium.The changes of serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), vitamin B12 and homocysteine (Hcy) levels before and after treatment between the two groups were observed.The maternal and neonatal outcomes were analyzed.Results After treatment, TSH level in the study group was lower than that in the routine group, with statistically significant difference (P＜0.05).FT3 and FT4 levels after treatment in the study group were higher than those in the routine group, with statistically significant differences (P＜0.05).Vitamin B12 level in the study group after treatment was higher than that in the routine group, with statistically significant difference (P＜0.05).The total incidence of poor maternal and neonatal outcomes in the study group (2.33%) was lower than that in the routine group (16.28%), with statistically significant difference (P＜0.05).Conclusion Levothyroxine Sodium can improve the thyroid hormone levels, reduce the incidence of poor maternal and neonatal outcomes and play a role in the long-term fetal development. 2020 Vol. 27 (22): 131-133转137 [Abstract] ( 43 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 134 Analysis of related factors and bacteriological structure of puerperal infection LIN Fang；QIN Wei；ZHONG Ai-qun；ZHANG Dong-wu Objective To explore the related factors and etiological structure of puerperal infection, and to provide evidence-based evidence for the prevention and control of puerperal infection.Methods The clinical data of 105 cases of puerperal infection in Foshan Gaoming Hospital Affiliated to Guangdong Medical University from January 2017 to December 2019 were retrospectively analyzed, and they were set as the study group, and 100 cases of normal pregnant women in the same period were randomly selected as the control group.The factors of puerperal infection were analyzed, bacteriological detection was carried out on puerperal infection patients and the pathogenic structure was analyzed.Results The results of univariate analysis showed that there were significant differences between the study group and the control group in the aspects of age, antenatal hemoglobin, antenatal genital tract secretion, second stage of labor, perinatal complications, postpartum hemorrhage and delivery mode, blood transfusion (P＜0.05).Multivariate Logistic regression analysis showed that moderate prenatal anemia, infection of reproductive tract, prolonged second stage of labor and perinatal complications were independent risk factors of puerperal infection (P＜0.05).The results of bacteriological culture showed that Gram-negative bacteria accounted for 72.5%, Escherichia coli, Klebsiella pneumoniae and Gardnerella vaginalis ranked the top three.Gram-positive bacteria accounted for 27.5%, Staphylococcus aureus, Enterococcus faecalis and Staphylococcus epidermidis ranked the top three.Conclusion Correcting prenatal anemia, preventing reproductive tract inflammation, controlling the second stage of labor and other factors may be effective in preventing puerperal infection; Gram-negative bacteria are important pathogens of puerperal infection. 2020 Vol. 27 (22): 134-137 [Abstract] ( 37 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 138 Clinical effect of Atosiban combined with Ritodrine Hydrochloride in the treatment of advanced threatened abortion WU Dan-dan Objective To explore the clinical effect of Atosiban combined with Ritodrine hydrochloride in the treatment of advanced threatened abortion.Methods A total of 102 patients with advanced threatened abortion from October 2015 to October 2018 were selected as research subjects, and were divided into the study group and the control group by the random number table method, with 51 cases in each group.The control group was treated with Magnesium Sulfate combined with Ritodrine Hydrochloride, while the study group was treated with Atosiban combined with Ritodrine Hydrochloride.The levels of sex hormones (progesterone [P], estriol [E3]) were compared between the two groups before treatment and after 5 d of treatment.The pregnancy outcomes (neonatal Apgar score at 1 min after birth, low weight infant rate, fetal loss rate) were compared between the two groups.Results After treatment, the P level in the study group was higher than that before treatment (P＜0.05), and the P level in the study group was higher than that in the control group (P＜0.05), and the E3 level in the study group after treatment was lower than that before treatment (P＜0.05), and the E3 level in the study group was lower than that in the control group (P＜0.05).The incidence rate of low birth weight infants in the study group was lower than that in the control group (P＜0.05), and there were no significant differences in the neonatal Apgar score at 1 min after birth and fetal loss rate between the two groups (P＞0.05).Conclusion Atosiban for advanced threatened abortion can improve the sex hormones levels and pregnancy outcomes of patients. 2020 Vol. 27 (22): 138-140 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 141 Application of the sports beverage-based diet management model in maternal labor during gestational diabetes LYU Wei Objective To explore the application of sports beverage-based diet management model in the parturition of pregnant women with gestational diabetes.Methods A total of 86 cases of pregnant women with gestational diabetes admitted to our hospital from January 2017 to December 2018 were selected as the study objects.According to the alternating grouping method, they were divided into the reference group (43 cases) and the nursing group (43 cases).The reference group adopted the free diet mode method, while the nursing group implemented the sports beverage-based diet management model.The blood glucose levels at different stages of labor, duration of labor and incidence of neonatal hypoglycemia were compared between the two groups.Results Before diet management, there was no significant difference in blood glucose level between the two groups (P＞0.05).After diet management, the blood glucose levels of the nursing group during delivery, after delivery, at the second stage of labor, from the active stage to the uterine opening were higher than those of the reference group, the differences were statistically significant (P＜0.05).The second stage of labor and the full time from the active stage to the uterine mouth in the nursing group were shorter than those in the reference group, with statistically significant differences (P＜0.05).The incidence of neonatal hypoglycemia in the nursing group (4.65%) was lower than that in the reference group (25.58%), with statistically significant difference (P＜0.05).Conclusion Compared with the conventional diet management mode, the sports beverage-based diet management mode in the labor process of gestational diabetic women has more obvious advantages, which can significantly improve maternal blood glucose level, shorten the labor process, and reduce the incidence of neonatal hypoglycemia. 2020 Vol. 27 (22): 141-143 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 144 Application effect of combined lumbar stiffness and bypass puncture in the prevention of low back pain during cesarean section anesthesia LIU Gen-feng；HUANG You-fang；LIU Yi LIU Qiong；ZHONG En-hui Objective To explore the application effect combined lumbar stiffness and bypass puncture in the prevention of low back pain during cesarean section anesthesia.Methods A total of 500 patients with cesarean section who were admitted to the hospital from April 2018 to September 2019 were selected as the research objects.The coin toss method was used randomly to divided patients into observation group and control group, with 250 cases in each group.The observation group used bypass puncture, and the control group used median puncture.Both groups underwent combined lumbar and hard anesthesia.The anesthesia effect, anesthesia related indexes, adverse reactions and low back pain were compared between the two groups.Results The total anesthesia comfort of the observation group was higher than that in the control group, and the total incidence of adverse reactions was lower than that in the control group, the differences were statistically significant (P＜0.05).The onset of anesthesia effect time and anesthesia operation time in the observation group were shorter than those in the control group, and the dosage was less than that in the control group, the differences were statistically significant (P＜0.05); the incidence of low back pain at 3 weeks after operation in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion The application of lumbar stiffness combined with bypass puncture in the anesthesia of cesarean section is effective in the clinical anesthesia, effectively reducing the incidence of low back pain and the incidence of adverse reactions in patients, meeting the anesthesia needs of patients, and worthy of popularization and application. 2020 Vol. 27 (22): 144-146 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 147 Influence of low-dose constant-rate infusion of Dexmedetomidine after surgery on the effect of patient-controlled intravenous analgesia and recovery of gastrointestinal function YANG Hai-hui；WANG Bing；LI Chang-ke；HUANG Huan-sen Objective To explore the influence of low-dose constant-rate infusion of Dexmedetomidine after surgery on the effect of patient-controlled intravenous analgesia (PCIA) and recovery of gastrointestinal function.Methods A total of 60 cases of gynecological patients who underwent laparoscopic surgery from January to October in 2019 in Yue Bei People′s Hospital were selected as the research objects, and were divided into group S (sufentanil group) and group D(dexmedetomidine group) according to the random double-blind method, 30 cases in each group.While the analgesic pump was turned on, group D was given a small dose of Dexmedetomidine by intravenous infusion at a constant rate,and group S was given an equal amount of saline at a constant rate.Vital signs, pain digital score (NRS) scores at four time points of 4, 8, 12, and 24 hours postoperatively, the number of analgesic pump compressions within 48 hours, the amount of Sufentanil, and recovery of gastrointestinal function time and occurrence of other adverse reactions were compared between the two groups of patients.Results The NRS scores of patients in group D were lower than those in group S at 4, 8, 12, and 24 hours after surgery, and the differences were statistically significant (P＜0.05).The number of intravenously controlled analgesic compressions and the total amount of Sufentanil in group D were less than those in group S within 2 days after surgery, and the recovery time of gastrointestinal function was shorter than that in group S,the differences were statistically significant (P＜0.05).The incidence of nausea and vomiting in group D was lower than that in group S, the difference was statistically significant (P＜0.05).Conclusion The low-dose constant-rate infusion of Dexmedetomidine after surgery can reduce the dose of intravenous self-controlled analgesic drugs, shorten the recovery time of gastrointestinal function, and reduce the incidence of nausea and vomiting in patients undergoing gynecological laparotomy.It is worthy of clinical promotion. 2020 Vol. 27 (22): 147-149转153 [Abstract] ( 33 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 150 Application of Sevoflurane combined with Dexmedetomidine in pediatric cheilopalatognathus surgery ZHAO Zhi-juan Objective To investigate the application of Sevoflurane combined with Dexmedetomidine in pediatric cheilopalatognathus surgery.Methods A total of 50 children patients with cheilopalatognathus who received treatment between January 2018 and September 2019 in the Second Affiliated Hospital of Jinzhou Medical University were selected as the research objects.The selected children were divided into group C and group D according to random number table method, 25 cases in each group.Group C used Sevoflurane alone as inhalation anesthesia, and the group D used Sevoflurane combined with Dexmedetomidine.The heart rate (HR), mean arterial pressure (MAP) were compared between the two groups at the beginning of anesthesia (T0), at the beginning of operation (T1) and at the time of extubation (T2).The recovery time and the occurrence of adverse reactions were compared between the two groups.Results The HR and MAP at T1 and T2 in group D were lower than those in group C, the differences were statistically significant (P＜0.05).In group C, HR and MAP were higher at T1 and T2 than those at T0, the differences were statistically significant (P＜0.05).In group D, there were no significant differences in HR and MAP at T0, T1 and T2 (P＞0.05).There was no significant difference in the recovery time between the two groups (P＞0.05).The incidence of emergence agitation in group D was lower than that in group C, the difference was statistically significant (P ＜0.05).Conclusion Sevoflurane combined with Dexmedetomidine in pediatric cheilopalatognathus surgery achieves stable hemodynamics and low incidence of emergence agitation. 2020 Vol. 27 (22): 150-153 [Abstract] ( 30 ) HTML (43 KB)  PDF  (0 KB)  ( 7 ) 154 Application of ultrasound-guided Ropivacaine for abdominal transverse fascia block combined with Parecoxib Sodium in postoperative analgesia in patients undergoing laparoscopic gastric volume reduction surgery WEI Guo-hua；WANG Juan Objective To investigate the application of ultrasound-guided Ropivacaine for abdominal transverse fascia block combined with Parecoxib Sodium in postoperative analgesia in patients undergoing laparoscopic gastric volume reduction surgery.Methods A total of 80 cases of undergoing laparoscopic gastric volume reduction surgery patients admitted to our hospital from January to August 2019 were selected as the research objects, and were divided into a treatment group (40 cases) and a control group (40 cases) according to random number table method.The treatment group was given laparoscopic gastric volume reduction surgery and Ropivacaine transversal fascia block, and the control group was given laparoscopic gastric volume reduction surgery.The two groups patients were compared in terms of visual analogue scale (VAS), opioid use after surgery, anal exhaust time (the time from the end of the surgery to the first exhaust), and the hospital stays.Results The resting VAS scores of patients in the treatment group were lower than those in the control group at 1 and 6 hours after surgery, the opioid use rate at 48 hours after surgery in the treatment group was lower than that in the control group, and the postoperative nausea and vomiting score were lower than those in the control group, and anal exhaust time was shorter than that in the control group, with statistically significant differences (P＜0.05).There were no statistically significant differences in resting VAS scores and hospital stays between the two groups of patients at 12 and 24 hours after surgery (P＜0.05).Conclusion Ultrasound-guided abdominal transverse fascia block combined with Parecoxib Sodium for laparoscopic gastric volume reduction surgery can reduce postoperative pain score, postoperative nausea and vomiting score, reduce opioid use, and benefit the recovery of intestinal function. 2020 Vol. 27 (22): 154-156 [Abstract] ( 35 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 157 Study on ultrasound parameters of uterine artery and fetal umbilical artery in patients with pregnancy induced hypertension and pregnancy outcome ZHU Dong-ping；ZHU Li-qun；GU Qing-ying Objective To explore the changes of ultrasound parameters of uterine artery and fetal umbilical artery in patients with pregnancy induced hypertension and the outcome of pregnancy.Methods A total of 60 cases of parturients who were admitted to our hospital from January 2019 to January 2020 were selected as the research objects.According to their pregnancy conditions, they were divided into the pregnancy hypertension group (30 cases) and the normal pregnancy group (30 cases).Ultrasound examination of uterine artery and fetal umbilical artery was used in the two groups.The pregnancy outcome of the two groups was compared.Results The results of uterine artery blood flow parameters such as arterial pulsatility index (PI), systolic blood pressure maximum blood flow velocity/end diastolic blood flow velocity (S/D) in the pregnancy hypertension group were higher than those in the normal pregnancy group (P＜0.05).The results of PI, S/D and other fetal umbilical artery blood flow parameters in the pregnancy hypertension group were higher than those in the normal pregnancy group (P＜0.05).But there was no significant difference in resistance index(RI) between the two groups (P＞0.05).The incidence rates of fetal distress, neonatal growth restriction, neonatal asphyxia, cesarean section and premature delivery in the pregnancy hypertension group were higher than those in the normal pregnant group, and the neonatal weight and Apgar score in the pregnancy hypertension group was lower than that in the normal pregnancy group (P＜0.05).Conclusion Compared with the healthy pregnant women, the uterine artery blood perfusion of the patients with pregnancy induced hypertension is significantly higher, and the fetal umbilical artery blood flow resistance is higher, which affects the growth and development of the fetus, so the diagnosis and treatment should be strengthened. 2020 Vol. 27 (22): 157-159 [Abstract] ( 33 ) HTML (29 KB)  PDF  (0 KB)  ( 5 ) 160 Clinical value comparison of multislice spiral CT and X-ray in the diagnosis of New Cryptococcal pneumonia WANG Xue-mei；LIU Yan-ling；TANG Hui Objective To compare the clinical value of multi-slice spiral CT and X-ray in the diagnosis of New Cryptococcal pneumonia.Methods A total of 100 patients with suspected New Cryptococcal pneumonia treated in our hospital from June 2016 to May 2019 were selected as the research subjects.All patients underwent X-ray examination,multi-slice spiral CT examination.Pathological diagnosis was set as the gold standard, the detection results of lesions and signs of the two methods were compared.Results The lesion detection rate, sign detection rate, specificity, sensitivity, and accuracy of the multi-slice spiral CT examination were significantly higher than those of the X-ray examination, and the missed and misdiagnosed rates of the multi-slice spiral CT examination were significantly lower than those of the X-ray examination, the differences were statistically significant (P＜0.05).Conclusion Multi-slice spiral CT scan has a higher detection rate of New Cryptococcal pneumonia, and its clinical application value is significantly higher than that of X-ray, which is worth popularizing widespreadly in clinic. 2020 Vol. 27 (22): 160-162 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 163 Value of color Doppler ultrasound combined with electrocardiogram in the diagnosis of hypertensive heart disease DING Lin-ling；LI Wen；WANG Meng-jun；WU Gao-bo；HE Hui；HU Jiao Objective To explore the value of color Doppler ultrasound combined with electrocardiogram in the diagnosis of hypertensive heart disease.Methods From January 2019 to December 2019, 72 patients suspected with hypertensive heart disease in our hospital were selected.After admission, all patients were examined by electrocardiogram and color Doppler ultrasound.The sensitivity,specificity and accuracy of electrocardiogram,color Doppler ultrasound and their combined examination in the diagnosis of hypertensive heart disease were compared,and the detection rates of electrocardiogram,color Doppler ultrasound and their combined examination in different types of hypertensive heart disease were compared.Results The sensitivity,specificity and accuracy of color Doppler ultrasound and combined examination in the diagnosis of hypertensive heart disease were higher than those of electrocardiogram, the differences were statistically significant (P＜0.05).There were no significant differences in the sensitivity, specificity and accuracy between color Doppler ultrasound and combined examination(P＞0.05).The detection rates of left ventricular enlargement,left ventricular posterior wall hypertrophy, interventricular hypertrophy and left ventricular hypertrophy of color Doppler ultrasound and combined examination were significantly higher than those of electrocardiogram, the differences were statistically significant(P＜0.05).The detection rate of left ventricular enlargement of color Doppler ultrasound was lower than thoat of combined examination (P＜0.05), and there were no significant difference in the detection rates of left ventricular posterior wall hypertrophy, interventricular hypertrophy and left ventricular hypertrophy between color Doppler ultrasound and combined examination (P＞0.05).Conclusion The application value of color Doppler ultrasound in hypertensive heart disease is significant, and the diagnostic efficiency is higher than that of electrocardiogram, which combined with electrocardiogram examination is helpful to improve the accuracy of the examination of patients with hypertensive heart disease. 2020 Vol. 27 (22): 163-165 [Abstract] ( 33 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 166 Effect evaluation and cost-effectiveness analysis on intervention of rational drug use by pharmacists in perioperative period of cesarean section YAN Fei；XU Wen-qing；LE Liang Objective To analyze the effect evaluation and cost-effectiveness on intervention of rational drug use by pharmacists in perioperative period of cesarean section, so as to promote rational drug use.Methods A total of 100 cases of cesarean section before the intervention (from April 2017 to March 2018) were randomly selected as the preintervention group, and 100 cesarean section cases after the pharmacist participated in the intervention (from April 2018 to March 2019) were selected as the post-intervention group for retrospective evaluation and analysis.Results After intervention, the rational rate of antibiotic selection in perioperative period increased from 75% to 93% (χ2=12.05,P=0.00), the rational rate of time points of prophylaxis use of antimicrobial increased from 79% to 95% (χ2=11.32, P=0.00), and the rational rate of medication time of the preventive application of antibacterials increased from 67% to 92% (χ2=19.18, P=0.00).The results of cost-effectiveness analysis showed that the cost-effectiveness ratio (C/E) of antibiotics decreased from 0.26 to 0.06 after intervention, and the C/E of drug costs decreased from 16.97 to 9.89 after intervention.Conclusion Both the analysis of intervention effect and the evaluation of pharmacoeconomics show that pharmacists intervention could effectively promote the rational use of antibiotics in perioperative period of cesarean section. 2020 Vol. 27 (22): 166-169 [Abstract] ( 38 ) HTML (39 KB)  PDF  (0 KB)  ( 6 ) 170 Effect of "one disease and one product" on the awareness rate and selfefficacy of appendicitis patients undergoing laparoscopic resection YU Guang-ting Objective To investigate the effect of "one disease and one product" on the awareness rate and self-efficacy of patients with appendicitis undergoing laparoscopic resection.Methods A total of 82 patients with appendicitis who underwent laparoscopic resection in our hospital from June 2017 to August 2019 were selected as the research objects, and they were divided into the control group (n=41) and the observation group (n=41) according to the random number table method.The control group received routine nursing, and the observation group was combined with "one disease and one product" nursing intervention on the basis of the control group.The awareness rate, general self-efficacy scale score before and after nursing and the total incidence rate of postoperative complications in the two groups were compared.Results The awareness rates of disease etiology, treatment method, surgical prognosis, rehabilitation exercise, regular review and dietary intervention in the observation group after 7 days of nursing were higher than those in the control group, and the differences were statistically significant (P＜0.05).The scores of daily life, health behavior,compliance behavior and emotional management in the observation group after 7 days of nursing were higher than those in the control group, and the differences were statistically significant (P＜0.05).The total incidence rate of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The "one disease and one product" nursing model can improve the awareness rate and enhance the self-efficacy level in patients with appendicitis undergoing laparoscopic resection.It is worthy of popularization and application. 2020 Vol. 27 (22): 170-172转177 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 173 Analysis on the risk factors of vitamin D deficiency in children aged 6-9 years old SUN Guan-nan；TONG Yan-rui；XU Li-ping；YE Yan-hong；WANG Bang-xiang Objective To analyze the risk factors of vitamin D deficiency in children aged 6-9 years old.Methods From July 2018 to July 2019, the data of serum 25-hydroxyvitamin D, that was 25-(OH)D, for children aged 6 to 9 years who came from the Outpatient Clinic of Child Healthcare Department in People′s Hospital of Ningxia Hui Autonomous Region were collected.The data of 204 children aged 6 to 9 years were collected by self-designed questionnaire and then analyzed for correlative factors.The children were divided into two groups according to their serum 25-(OH)D levels: normal vitamin D group (n=77) and vitamin D deficiency group (n=127).Univariate analysis and binary Logistic regression were used to analyze the factors affecting vitamin D deficiency.Results Statistically significant differences were found between normal vitamin D group and vitamin D deficiency group in season of examination, cod liver oil supplementation before the age of 2 years old, average daily outdoor activity time in the past one month, average sun exposure area in the past one month, sunscreen usage, milk drinking, egg eating, seafood eating, fungus eating, and oral cod liver oil intake in the past two months (P＜0.05).Winter (OR=4.473, 95%CI: 1.240-16.132, P=0.022), irregular cod liver oil supplementation before 2 years old (OR=8.261, 95%CI: 3.058-22.311, P＜0.001), never eating eggs (OR=7.593,95%CI:1.732-33.294, P=0.007), occasionally eating eggs(OR=11.292, 95%CI: 3.681-34.639, P ＜0.001), never eating seafood (OR=7.303, 95%CI: 1.494-35.696, P=0.014); occasionally eating seafood (OR=10.625, 95%CI:2.373-47.575, P ＝0.002) were independent risk factors for vitamin D deficiency.Conclusion The risk factors of vitamin D deficiency are winter, irregular supplementation of cod liver oil and before 2 years old, lack of frequent eggs eating and seafood eating. 2020 Vol. 27 (22): 173-177 [Abstract] ( 36 ) HTML (44 KB)  PDF  (0 KB)  ( 8 ) 178 The role of quality control circle activities combined with safety nursing in improving the qualification rate of basic nursing for patients 24 hours after operation ZHANG Ping；HUANG Hong；XU Hui-hui；ZHAI Xiao-li Objective To explore the role of quality control circle (QCC) activities combined with safety nursing in improving the qualification rate of basic nursing for patients 24 hours after operation.Methods A total of 80 surgical patients admitted to our hospital from February 2018 to September 2019 were selected as the research objects.They were divided into control group and observation group by screening method and whole group sampling method, each had 40 cases.The patients in the control group received routine nursing, while the patients in the observation group received safety nursing and QCC activities.The eligible rate of 24-hour basic nursing and the total risk rate of different intervention were compared between the two groups.Results The qualified rate of basic nursing 24 hours after operation in the observation group was 97.50%, higher than 85.00% in the control group, the difference was statistically significant(P＜0.05); the total incidence of nursing risk in the observation group was 10.00%, lower than 30.00% in the control group, the total difference was statistically significant(P＜0.05).Conclusion The combination of safety nursing and QCC can significantly improve the qualified rate of examination and nursing 24 hours after operation, reduce the occurrence of nursing risk and improve the safety of nursing. 2020 Vol. 27 (22): 178-180 [Abstract] ( 28 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 181 Effect of clinical pharmacists′ participation in clinical pathway management of ovarian benign tumor by PDCA circulation ZHONG Mei-gong；TAN Wen-qiang；WU Zhuo-jian；LIANG Fa-liang Objective To explore the methods and effect of clinical pharmacists′ participating in the clinical pathway management of ovarian benign tumors by PDCA circulation.Methods From November 2018 to October 2019, 120 inpatients with ovarian benign tumor who met the criteria of clinical pathway of ovarian benign tumor were selected as the study objects, according to the method of random number table, they were divided into the observation group and the control group, 60 cases in each group.The routine clinical pathway management of ovarian benign tumor was implemented in the control group, and the PDCA cycle clinical pathway management of clinical pharmacists was implemented in the observation group.The observation group was divided into the observation group 1 and the observation group 2 according to the different cycle, 30 cases in the each group.The first PDCA cycle was implemented in the observation group 1 (from November 2018 to April 2019), and the second PDCA cycle was implemented in the observation group 2 (from May to October 2019).The cost condition, auxiliary medication condition, rational use of prophylactic antibiotics and follow-up compliance of patients in the each group were recorded.Results There was no statistically significant difference in the length of hospital stay among the three groups (P＞0.05); the hospitalization cost of the observation group 2 was lower than that of the observation group 1 and the control group, and the differences were statistically significant (P＜0.05); there was no statistically significant difference in hospitalization expenses between the observation group 1 and the control group (P＞0.05); in terms of drug costs, the control group＞observation 1 group＞observation 2 groups, the differences among the three groups were statistically significant (P＜0.05).Observation group 1 and observation group 2 had fewer auxiliary medication costs and medication varieties than the control group, and the differences were statistically significant (P＜0.05); and observation 2 groups had fewer auxiliary medication costs and medication varieties than observation 1 group, the differences were statistically significant (P＜0.05).The reasonable rate of antimicrobial use in observation group 1 and observation group 2 was all higher than that in the control group, and the differences were statistically significant (P＜0.05); follow-up compliance rate of observation group 1 was higher than that in the the control group, the difference was statistically significant (P＜0.05); there was no statistically significant difference between the observation group 2 and the control group in follow-up compliance rate (P＞0.05); there was no statistically significant difference between the observation group 1 and the observation group 2 in the reasonable rate of antimicrobial use and follow-up compliance rate(P＞0.05).Conclusion The PDCA method to continuously optimize the clinical pharmacist′s participation in clinical path management can better standardize clinical medication and ensure patients′ safe medication.After the second cycle, hospitalization costs, drug costs, auxiliary drug costs, and the number of drug types have all been further optimized, showing that continuous optimization management is essential. 2020 Vol. 27 (22): 181-184 [Abstract] ( 32 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 185 Application of Huoxiang Zhengqi Liquid in newborns with toxic erythema WANG Xi-rong Objective To investigate the application of Huoxiang Zhengqi Liquid in newborns with toxic erythema.Methods A total of 300 newborns with toxic erythema who were admitted to our hospital from January 2017 to January 2019 were selected and divided into control group (n=150) and observation group (n=150) according to random number table method.The control group was bathed with conventional water, and the observation group was bathed with 1%Huoxiang Zhengqi liquid solution.The clinical curative effect, daily sleep time, daily milk feeding volume, healing time and satisfaction of family members were compared between two groups.Results The total effective rate of observation group (96.00%) was higher than that of control group (74.00%) (P＜0.05).The daily sleep time of observation group was longer than that of control group, the daily milk feeding volume of observation group was higher than that of control group, and the healing time of observation group was shorter than that of control group, the differences were statistically significant (P＜0.05).The total satisfaction of family members in observation group (90.67%) was higher than that in control group (64.67%) (P＜0.05); the severity of toxic erythema in observation group was lighter than that in control group, the difference was statistically significant (P＜0.05).Conclusion Huoxiang Zhengqi Liquid in treatment of newborns with toxic erythema can enhance clinical curative effect, increase milk feeding volume and daily sleep time of newborns, promote wound healing of erythema and increase satisfaction of family members. 2020 Vol. 27 (22): 185-187 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 188 Effect of systematic nursing intervention on nutritional status and psychological status of postoperative patients with nasal feeding after laryngeal cancer surgery DUAN Liu-hua Objective To investigate the effect of systematic nursing intervention on nutritional status and psychological status of postoperative patients with nasal feeding after laryngeal cancer surgery.Methods A total of 92 patients with laryngeal cancer treated in our hospital from December 2017 to December 2019 were selected and divided into two groups according to the random number table method, 46 cases in each group.The control group received routine nursing and the observation group received systematic nursing intervention.The nutritional status of hemoglobin (Hb),serum albumin(ALB) and prealbumin (PA) before and after 7 days intervention were compared between the two groups,self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess the mental status of patients.Results There were no significant differences in Hb, ALB, PA, SAS, and SDS scores between the two groups before intervention (P＞0.05).The Hb for (135.67±22.54) g/L, ALB for (2.57±6.53) g/L, and PA for (235.37±35.528) mg/L in the observation group after intervention were higher than (111.53±21.54) g/L, (32.57±6.52) g/L, (199.87±28.54) mg/L in the control group, the differences were statistically significant (P＜0.05).The SAS score of the observation group after the intervention was (24.56±4.26) points and the SDS score was (28.97±8.52) points, which were lower than the control group′s (34.67±7.52) points and (36.57±5.24) points, with statistical differences (P＜0.05).Conclusion Systemic nursing intervention can improve the nutritional status and relieve anxiety, depression and other negative emotions of patients with nasal feeding after laryngeal cancer. 2020 Vol. 27 (22): 188-190 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 191 Application effect comparison of anesthesia nursing and routine nursing in operating room in surgical nursing HUANG Li-ling；LI You-chun Objective To compare the application effect of anesthesia nursing and routine nursing in operating room in surgical nursing.Methods From May 2018 to April 2019, 200 patients undergoing surgical treatment in our hospital were selected as the study objects, and divided into experimental group (n=100) and control group (n=100) by random assignment.The control group adopted the routine nursing plan, the experimental group adopted the anesthesia nursing in the operating room, the clinical application effect of the experimental group and the control group were compared.Results The nursing total satisfaction of the experimental group was higher than that of the control group, and the scores of self rating depression scale (SDS), self-rating anxiety scale (SAS) and emotional rating scale (HADS) of the experimental group were lower than those of the control group, with statistical differences (P＜0.05).Conclusion Anesthesia nursing in surgical patients can not only improve patients′ nursing satisfaction, but also reduce the tension to the greatest extent.The nursing method is worthy of clinical application and promotion. 2020 Vol. 27 (22): 191-193 [Abstract] ( 36 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 194 Study on the influence of empathic psychological intervention on negative emotion and treatment compliance of cervical cancer patients CHEN Lan；ZHANG Wei；Tang Hui-jia Objective To study the influence of empathic psychological intervention on negative emotion and treatment compliance of cervical cancer patients.Methods A total of 82 cases of cervical cancer patients who visited our hospital from March 2018 to September 2019 were selected as study subjects, they were divided into the observation group and the control group according to random number table method, 41 cases in each group.The control group received routine psychological nursing and the observation group received empathic psychological intervention.Negative mood (Zung′s anxiety scale score [SAS], Zung′s depression scale score [SDS]) before nursing and 1 month after nursing, total treatment compliance and the total nursing satisfaction degree were recorded and compared between the two groups.Results The SAS and SDS scores of the observation group after nursing were lower than those of the control group and before nursing, the differences were statistically significant (P ＜0.05).The total compliance of the observation group was 95.1%, higher than that of the control group (78.1%), the difference was statistically significant (P＜0.05).The total nursing satisfaction degree in the observation group was 97.56%, which was higher than 82.93% in the control group,the difference was statistically significant (P＜0.05).Conclusion Empathic psychological intervention can effectively improve the negative emotions of patients with cervical cancer, enhance the treatment compliance of patients, and can be popularized in clinical. 2020 Vol. 27 (22): 194-196 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 197 Influence of Orem′s self-care theory combined with clinical nursing pathway on the quality of life and social function of schizophrenia LIU Yi-feng；LI Hua；GUO Shu-qing；CHEN Juan Objective To explore the influence of Orem self-care theory combined with clinical nursing pathway on the quality of life and social function of schizophrenia.Methods A total of 72 schizophrenics admitted to our hospital from February 2018 to September 2019 were selected as the research objects, and they were divided into the study group and the control group according to the random number table method, 36 cases in each group.The control group was given clinical nursing path nursing method, and the study group was given Orem self-care theory on the basis of the control group′s nursing.The activity of daily living scale（ADL）, social disability screening schedule （SDSS） and rehabilitation efficiency of the two groups were compared before and after 3 months intervention.Results The ADL score after 3 months intervention in the study group was higher than that in the control group, the difference was statistically significant （P＜0.05）; the SDSS score after 3 months intervention in the study group was lower than that in the control group, the difference was statistically significant （P＜0.05）.The total effective rate of rehabilitation in the study group was 77.78%, which was higher than 41.67% in the control group, the difference was statistically significant （P＜0.05）.Conclusion Orem self-care theory combined with clinical nursing pathway can effectively improve the quality of life and social function of schizophrenics, and the rehabilitation effect is ideal, which is worth of clinical promoting. 2020 Vol. 27 (22): 197-199 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 200 Application effect of comfortable nursing in rehabilitation nursing of schizophrenics JIANG Jian-mao；.CHEN Ze-qun；CHEN Ze-ying；WU Guang-bing Objective To explore the value of comfortable nursing in rehabilitation nursing of schizophrenics.Methods A total of 124 inpatients with schizophrenia admitted to the Mental Hospital of Guangzhou Civil Affairs Bureau from March 2018 to February 2019 were selected and they were divided into observation group (n=62, comfortable nursing+routine nursing) and control group (n=62, routine nursing) by random number table method.Before and after 6 months of nursing, the condition were evaluated by inpatient observation scale for psychiatric nurses (NOSIE) and the nursing total satisfaction of the two groups were investigated.Results After intervention, the scores of social ability, social interest and personal neatness in the observation group were higher than those in the control group, and the scores of irritability, mental illness and depression were lower than those in the control group, and the differences were statistically significant (P＜0.05).The nursing total satisfaction of the observation group (96.77%) was higher than that of the control group (83.87%), and the difference was statistically significant (P＜0.05).Conclusion The application of comfortable nursing in schizophrenia has a good effect, it can effectively improve the mental state of patients and improve nursing satisfaction.It is recommended to promote. 2020 Vol. 27 (22): 200-202 [Abstract] ( 36 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 203 Application of high quality nursing mode in patients with stable chronic obstructive pulmonary disease FAN Hua-ying；PENG Xiao-hua；ZHANG Chun-yu；LI Lu-hong Objective To explore the application of high quality nursing mode in patients with stable chronic obstructive pulmonary disease (COPD).Methods From March 2019 to January 2020, 60 patients with stable COPD in our hospital were selected as the research objects.According to the random comprehensive balance method, they were divided into control group (n=30) and observation group (n=30).The control group adopted the conventional nursing mode, and the observation group adopted the high-quality nursing mode.The scores of self-management ability, quality of life, self rating anxiety scale (SAS) and self rating depression scale (SDS) were compared between the two groups.Results The scores of respiratory function exercise, whole body exercise, family oxygen therapy and medicine compliance in the observation group were higher than those in the control group, the differences were statistically significant(P＜0.05).The quality of life score of the observation group was higher than that of the control group (P＜0.05).The scores of SAS and SDS in the two groups after intervention were lower than those before intervention, and the scores of SAS and SDS in the observation group after intervention were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The application of high quality nursing mode in patients with COPD in stable stage can improve their self-management ability and quality of life, and help them overcome the negative emotions such as anxiety and depression, which is worthy of clinical promotion. 2020 Vol. 27 (22): 203-205 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 206 Application effect of holistic nursing mode in patients with cerebral infarction and its influence on dysphagia CHEN Xiao-piao；RAO Lu Objective To explore the application effect of holistic nursing mode in patients with cerebral infarction(CIS) and its influence on dysphagia.Methods A total of 70 patients with CIS admitted to our hospital from January 2018 to July 2019 were selected as the research objects.According to random number table method, they were divided into the observation group (n=35) and the control group (n=35).The control group applied routine nursing, and the observation group was given holistic nursing mode on the basis of the control group.The scores of daily living ability, the scores of water swallow test before and after nursing and the total satisfaction degree of nursing were compared between the two groups.Results There was no significant difference the ability of daily living score between the two groups before nursing (P＞0.05)； the scores of the ability of daily living of the two groups after nursing were higher than those before nursing, and the score of the ability of daily living of the observation group after nursing was higher than that of the control group, the differences were statistical significant (P＜0.05).There was no significant difference score of water swallow test between the two groups before nursing (P＞0.05)； the score of water swallow test after nursing in the two groups was lower than that before nursing, and the score of water swallow test after nursing in the observation group was lower than that in the control group, the differences were statistically significant (P＜0.05).The total satisfaction degree of observation group was 97.14%, which was higher than that in the control group (77.14%), the difference was statistically significant (P＜0.05).Conclusion The application effect of holistic nursing mode in patients with CIS is significant.It can improve the patients′ daily living ability, dysphagia symptoms and the nursing satisfaction, which is worthy of clinical promotion. 2020 Vol. 27 (22): 206-208转212 [Abstract] ( 31 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 209 Effect of diet intervention combined with equal length anti resistance exercise on blood glucose level and pregnancy outcome in patients with gestational diabetes mellitus FANG Hui-ping CHEN Xiao-yan DAI Xiao-wei；Xing Qiu-ping Objective To explore the effect of comprehensive intervention combined with equal length anti resistance exercise on blood glucose level and pregnancy outcome in patients with gestational diabetes mellitus (GDM).Methods A total of 120 patients with GDM admitted to our hospital from May to December 2019 were selected as research objects.According to random number table method, they were divided into control group (n=60) and observation group(n=60).The control group adopted comprehensive nursing intervention, and the observation group adopted comprehensive intervention combined with equal length anti resistance exercise nursing intervention.The blood glucose level and pregnancy outcomes in the two groups were compared.Results After intervention, glycosylated hemoglobin (HbA1c)was (5.68±1.02)%, blood glucose 2 hours after meal (2 h PG) was (5.59±0.88) mmol/L, fasting blood sugar (FPG) was(4.39±0.55) mmol/L, total incidence of adverse neonatal outcomes (11.67%) and perinatal period the total incidence of complications (1.67%) were lower than those of HbA1c for (6.90±1.28)%, 2 h PG for (7.48±1.33) mmol/L, FPG for(5.20±0.63) mmol/L, total incidence adverse outcome of newborn (41.67%) and perinatal complications (15.00%) in the control group, the differences were statistically significant (P＜0.05).Conclusion The patients with GDM who are given equal length anti resistance exercise nursing combined with comprehensive nursing intervention, the pregnancy outcome is effectively improved, and the application value is higher. 2020 Vol. 27 (22): 209-212 [Abstract] ( 34 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 213 Effect of comprehensive pain nursing mode on pain of children with indirect inguinal hernia ZHANG Zhen；XIAO Ju-hua；OUYANG Yu Objective To explore the effect of comprehensive pain nursing mode on the pain of children with indirect inguinal hernia.Methods A total of 60 children with indirect inguinal hernia admitted to our hospital from November 2018 to October 2019 were selected as the research objects, they were divided control group (n=30) and observation group (n=30) by the method of random comprehensive balance.The control group adopted the routine nursing method,and the observation group implemented the comprehensive pain nursing mode.The visual analogue scale (VAS) score,heart rate, blood pressure and the total incidence of complications were compared between the two groups.Results After intervention, the VAS score of the observation group was lower than that of the control group; the heart rate and blood pressure level of the observation group were lower than those of the control group; the total incidence of complications such as scrotal swelling and abdominal distention of the observation group was lower than that of the control group,the difference was statistically significant (P＜0.05).Conclusion The comprehensive nursing mode in children with indirect inguinal hernia can effectively relieve pain, improve heart rate and blood pressure, and reduce complications. 2020 Vol. 27 (22): 213-215 [Abstract] ( 40 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 216 Application effect of multi-dimensional rehabilitation nursing combined with psychological intervention in patients with schizophrenia XU Ai-xian；SUN De-di Objective To explore the application effect of multi-dimensional rehabilitation nursing combined with psychological intervention in patients with schizophrenia.Methods A retrospective analysis was performed on 58 patients with schizophrenia admitted to our hospital from February 2018 to February 2019.They were divided into two groups according to different nursing methods, 29 cases in each group.The control group was given routine nursing intervention, and the study group implemented multi-dimensional rehabilitation nursing combined psychological intervention.The symptoms, cognitive function, social function improvement and recurrence rate of schizophrenia were compared between the two groups.Results There were no significant differences between the two groups in the pre-intervention positive and negative symptom scale (PANSS), matrics consensus cognitive battery (MCCB), and the personal and social performance scale (PSP) scores (P＞0.05).After intervention, the PANSS score of the two groups was lower than that before intervention, MCCB and PSP scores were higher than those before intervention, with statistical differences (P＜0.05).After intervention, the PANSS score of the study group was lower than that of the control group, and the MCCB and PSP scores were higher than those of the control group, with statistical differences (P＜0.05).The recurrence rate in the study group within 6 months after discharge was 6.90%, which was slightly lower than 20.68% in the control group,but the difference was not statistically significant (P＞0.05).Conclusion Multi-dimensional rehabilitation nursing combined with psychological intervention has high application value in patients with schizophrenia, which can alleviate schizophrenia symptoms, improve cognitive and social functions, and reduce the recurrence rate. 2020 Vol. 27 (22): 216-218 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 219 Application effect of evidence-based nursing in patients with ovarian cancer treated with drug chemotherapy LIU Chun-mei；WANG Min；HUANG Ye Objective To explore the application effect of evidence-based nursing in patients with ovarian cancer treated with drug chemotherapy.Methods A total of 50 cases of ovarian cancer patients who received treatment in our hospital from January 2018 to January 2019 for comparative analysis were selected.According to the random grouping by computer, patients were divided into the control group (n=25) given basic nursing care and the research group (n=25) given evidence-based nursing care.The patients in the two groups were all treated with the same chemotherapy drugs.Psychological status, quality of life and drug stress response were compared between the two groups.Results Before nursing, there were no significant differences in anxiety scale score and depression scale score between the two groups (P＞0.05).After nursing, the scores of anxiety scale and depression scale in the research group were lower than those in the control group, with statistical differences (P＜0.05).The scores of physiological function, emotional state,physical function, social function and total health in the research group were higher than those in the control group,with statistical differences (P＜0.05).The incidence of drug allergy in the research group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Evidence-based nursing in patients with ovarian cancer can effectively improve negative emotion and quality of life, it can reduce the adverse reactions of chemotherapy to the greatest extent and ensure the quality of chemotherapy. 2020 Vol. 27 (22): 219-221 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 222 Effect of timing theory on self-care ability and quality of life of patients with early hemodialysis MAI Cui-fang；YAN Bi-yan；LIANG Cui-yun Objective To explore the effect of nursing intervention guided by timing theory on self-care ability and quality of life of early hemodialysis (HD) patients.Methods A total of 90 patients with end-stage renal disease undergoing HD in our hospital from October 2018 to June 2019 were selected as the study objects.According to the random number table method,the patients were divided into control group(n=45)and intervention group(n=45).The control group adopted the routine nursing intervention method, and the intervention group adopted the nursing intervention method guided by the timing theory.The self-care ability before and after the intervention, the total incidence of complications and the quality of life of the patients in the two groups were compared.Results The scores of self-care ability in the two groups were higher than those before the intervention, the differences were statistically significant (P＜0.05).Before the intervention, there was no significant difference between the two groups in the score of self-care ability (P＞0.05).After the intervention, the scores of self-care ability and quality of life in the intervention group were higher than those in the control group, and the total incidence of complications was lower than that in the control group, the differences were statistically significant (P＜0.05).Conclusion The nursing intervention guided by the timing theory can effectively improve the self-care ability of early HD patients, reduce the incidence of complications, and improve the quality of life. 2020 Vol. 27 (22): 222-225 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 226 Application effect of quality control circle activity in patients with dysphagia after stroke QIU Yu-xia；CHEN Mei-zhen；HE Li-yi；OU Hui-qin Objective To explore the application effect of quality control circle (QCC) activity in patients with dysphagia after stroke (CVA).Methods A total of 120 patients with CVA and dysphagia admitted to our hospital were selected, and 60 patients who had not undergone QCC activities from March to July 2018 were selected as the control group,and 60 patients from August to December 2018 implemented were classified into the observation group.The visible findings including the incidence of aspiration and the incidence of aspiration pneumonia and invisible outcomes were compared in the two groups.Results The incidence of aspiration and the incidence of aspiration pneumonia in the observation group were lower than those in the control group, with statistical differences (P＜0.05).After comparing the invisible outcomes in the two groups, the scores of interest in curriculum, perception on QCC, quality improvement methods, activity confidence, team spirit, cognition, communication and coordination were higher than those of the control group, with statistical differences (P＜0.05).Conclusion The implementation of QCC management for CVA patients with dysphagia can effectively reduce the incidence of aspiration and aspiration pneumonia.Meanwhile, it can improve the comprehensive literacy and overall ability of the circle members, and it is worthy of clinical promotion and application. 2020 Vol. 27 (22): 226-228 [Abstract] ( 34 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 229 Nursing research of predictive nursing procedure in the first aid of emergency patients with multiple fractured ribs LIANG Ya-ling；ZHOU Lan-fang；LAI Bi-ying；LIANG Yan-fen Objective To create the predictive nursing procedure in the first aid of emergency patients with multiple fracture ribs and explore its effect in improving the quality of first aid.Methods A total of 60 patients of multiple fractured ribs who were treated in our hospital from September 2017 to December 2019 were selected and divided into control group and experimental group according to the random number table method, 30 cases in each group.Patients of the control group were given routine nursing, while those in the experimental group were given predictive nursing procedure.The effective salvage time, hospital stays, visual analogue scale (VAS) scores after treating, total nursing satisfaction and the total complication rate were compared between the two groups.Results The salvage time and hospital stays of the experimental group were shorten than those of the control group, the VAS score of the experimental group was lower than that in the control group, and the nursing total satisfaction of the experimental group was higher than that in the control group, the differences were statistically significant (P＜0.05).There was no statistically significant difference between the total complication rate of the two groups (P＞0.05).Conclusion Predictive nursing procedure in the first aid of emergency patients with multiple fractured ribs can shorten the effective salvage time and hospital stays,relieve pain and improve the nursing satisfaction. 2020 Vol. 27 (22): 229-231 [Abstract] ( 36 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 232 Influence of continuous nursing on thyroid function and nursing quality of patients with subclinical hypothyroidism HUANG Xiao-jing；PENG Shuang-lin；CHEN Jian；ZENG Hui-ying；LIANG Hong-wei Objective To explore the influence of continuous nursing on thyroid function and nursing quality of patients with subclinical hypothyroidism.Methods A total of 62 patients with subclinical hypothyroidism admitted to our hospital from January to September 2019 were selected as the research subjects.They were divided into the reference group(n=31) and the experimental group (n=31) by envelope method.The control group used traditional nursing plan, the experimental group used traditional nursing plan combined with continuous nursing.The thyroid function index level,compliance behavior and total incidence of adverse reactions were compared between the two groups.Results There were no significant differences in the levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) between the two groups before nursing (P＞0.05).The TSH level of the two groups after nursing was lower than that before nursing, the levels of FT3 and FT4 were higher than those before nursing, the differences were statistically significant (P＜0.05).The TSH level of the experimental group after nursing was lower than that of the reference group (P＜0.05）.There were no significant differences in the levels of FT3 and FT4 after nursing between the two groups(P＞0.05）.The compliance rate of scientific diet, timely medication and functional exercise in the experimental group were higher than those in the reference group (P＜0.05）.There were no significant differences in the levels of FT3 and FT4 between the two groups after nursing (P＞0.05）.The total incidence of adverse reactions in the experimental group(6.45%) was lower than that in the reference group (38.71%), the difference was statistically significant (P＜0.05).Conclusion After continuous nursing intervention, subclinical hypothyroidism patients can improve TSH level in thyroid function index, promote the compliance rate of scientific diet, timely medication and functional exercise, and reduce adverse reactions. 2020 Vol. 27 (22): 232-235 [Abstract] ( 37 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 236 Application effect of individualized nursing combined with the concept of rapid rehabilitation on patients undergoing limb fracture surgery YAO Li Objective To observe the application effect of individualized nursing combined with the concept of rapid rehabilitation in patients undergoing limb fracture surgery.Methods A total of 90 patients from May 2018 to May 2019 in our hospital who underwent surgical treatment of limb fractures with stage Ⅰincision and reduction and internal fixation were selected and divided into the control group and the observation group, 45 cases in each group.The patients in the control group were given routine nursing, the observation group was given personalized nursing combined with the concept of rapid rehabilitation.The differences in fracture healing time, total complications, and total nursing satisfaction between the two groups were compared.Results The fracture healing time in the observation group was(5.34±1.02) weeks, shorter than that in the control group for (7.85±1.26) weeks (P＜0.05).The total incidence of complications in the observation group was 4.44%, lower than that in the control group for 20.00%, the difference was statistically significant (P＜0.05).The total satisfaction of the observation group was 95.56%, higher than that of the control group of 75.56%, the difference was statistically significant (P＜0.05).Conclusion Individualized nursing combined with rapid rehabilitation can shorten the time of fracture healing, reduce the incidence of complications and improve the satisfaction of nursing.It is recommended to be widely used in clinical practice. 2020 Vol. 27 (22): 236-238 [Abstract] ( 41 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 239 Application of holistic nursing in elderly patients undergoing laparoscopic radical resection of colorectal cancer CHENG Yuan Objective To explore the application effect of holistic nursing in elderly patients undergoing laparoscopic radical resection of colorectal cancer.Methods Altogether 64 elderly patients who underwent laparoscopic radical resection of colorectal cancer from May 2017 to May 2018 were selected and divided into observation group and control group according to the random number table method, 32 cases in each group.The observation group was given holistic nursing after operation and the control group adopted routine nursing.The nursing effect, negative psychology and total nursing satisfaction were compared between the two groups.Results Defecation time, anal exhaust time and hospitalization time of observation group were shorter than those in the control group, the differences were statistically significant(P＜0.05).Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD) scores of observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The total nursing satisfaction of the observation group (94.29%) was higher than that of the control group (68.57%), the difference was statistically significant (P＜0.05).Conclusion Holistic nursing shows significant effectiveness in elderly patients who undergo laparoscopic radical resection of colorectal cancer, which can accelerate the recovery, reduce psychological pressure, improve nursing satisfaction.The clinical application value is remarkable. 2020 Vol. 27 (22): 239-241 [Abstract] ( 33 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 242 Application of predictive nursing in postoperative patients with perianal abscess JIAO Yan Objective To explore the application of predictive nursing in postoperative patients with perianal abscess.Methods Altogether 94 patients with perianal abscess who were admitted to our hospital from February 2018 to March 2019 were selected as the research objects and divided into the control group (n=47) and the observation group (n=47)according to the random single and double number method.The control group adopted routine nursing, the observation group adopted predictive nursing.The changes of postoperative pain, psychological score and nursing quality were compared between the two groups.Results There was no statistically significant difference between the two groups in pain score before nursing (P＞0.05).The pain scores of the observation group after nursing for 2 and 5 days were lower than those of the control group, with statistical differences (P＜0.05).There were no statistically significant differences in the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores before nursing between the two groups (P＞0.05).The scores of SAS and SDS after nursing in the two groups were lower than those before nursing,and the scores of SAS and SDS after nursing in the observation group were lower than those in the control group, with statistical differences (P＜0.05).The scores of nursing work ability, nurse-patient relationship, patient compliance and nursing attitude in the observation group were higher than those in the control group, with statistical differences (P＜0.05).Conclusion Application of predictive nursing in postoperative patients with perianal abscess can effectively reduce postoperative pain, improve depression and anxiety scores, and promote nursing quality scores, which is of great clinical significance. 2020 Vol. 27 (22): 242-244 [Abstract] ( 41 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 245 Application of nursing intervention mode in stages in patients with Parkinson′s disease LI Xiao-ping；JIANG Hong-chun；LI Jing-chao；LIANG Hong-yu；HU Yu；MA Hong-mei；XIU Wen-na Objective To explore the application effect of the nursing intervention mode in stages in patients with Parkinson′s disease (PD).Methods Eighty patients with PD admitted to our hospital from October 2017 to October 2018 were selected as the research objects.They were divided into control group (n=40) and observation group (n=40)according to the random number table method.In the control group, conventional nursing was used, and in the observation group, nursing intervention mode in stages was used.The nursing total satisfaction, life self-care ability score and total treatment compliance of the two groups were compared.Results The nursing total satisfaction of the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The self-care ability score and total treatment compliance of the observation group were higher than those in the control group, with statistical differences (P＜0.05).Conclusion Implementing staged nursing intervention for patients with PD is beneficial to improving the nursing satisfaction of patients and their families, increasing the patient′s treatment compliance, and promoting patient′s self-care in favorable effect, which is worthy of clinical promotion. 2020 Vol. 27 (22): 245-247 [Abstract] ( 41 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 248 Application effect of rapid rehabilitation nursing on patients with advanced esophageal cancer after esophageal stent placement ZHANG Chun-na Objective To explore the application effect of rapid rehabilitation nursing (ERAS) after esophageal stent placement in patients with advanced esophageal cancer.Methods A total of 100 patients with advanced esophageal cancer admitted to our hospital from January 2015 to December 2018 were selected as the research objects.They were divided into control group (n=50) and study group (n=50) by random drawing method.Routine nursing was used after the operation in the control group, and ERAS intervention was used after the placement of esophageal stent in the study group.The surgical-related indicators, mental state scores, and total clinical nursing satisfaction of the two groups were compared.Results The postoperative defecation time, postoperative exhaust time, postoperative time of being off bed,and hospital stay in the study group were shorter than those in the control group, the differences were statistically significant (P＜0.05).The self-rating anxiety scale (SAS) score and the self-rating depression scale (SDS) score in the study group were lower than those of the control group, the differences were statistically significant (P＜0.05).The total satisfaction of clinical nursing in the study group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion For advanced esophageal cancer performed with esophageal stent placement, it is of great value to jointly carry out ERAS intervention. 2020 Vol. 27 (22): 248-250 [Abstract] ( 32 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 251 Application of clinical nursing pathway intervention in patients with rectal cancer undergoing chemotherapy ZUO Jin-mei Objective To explore the application of clinical nursing pathway intervention in patients with rectal cancer undergoing chemotherapy.Methods From January 2017 to August 2019, 100 patients with rectal cancer treated by chemotherapy in our hospital were selected as the study objects.According to the random number table method, they were divided into the control group (n=50) and the observation group (n=50).The control group was given routine nursing, and the observation group was given clinical nursing path intervention.The health knowledge, the total incidence of adverse events and patients′ total satisfaction were compared between the two groups.Results After intervention, the scores of disease occurrence and development, treatment principle, basic knowledge of peripherally inserted central catheter (PICC) and precautions in the observation group were higher than those in the control group, with statistical differences (P＜0.05); the total incidence of adverse events in the observation group was lower than that in the control group, with statistical difference (P＜0.05); the total satisfaction of patients in the observation group was higher than that in the control group, with statistical difference (P＜0.05).Conclusion Clinical nursing pathway intervention can be used in patients with rectal cancer undergoing chemotherapy to improve their health knowledge and satisfaction and improve their safety. 2020 Vol. 27 (22): 251-253 [Abstract] ( 65 ) HTML (30 KB)  PDF  (0 KB)  ( 6 )

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