阿托西班联合盐酸利托君治疗晚期先兆流产的临床效果

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Abstract Objective To explore the clinical effect of Atosiban combined with Ritodrine hydrochloride in the treatment of advanced threatened abortion.Methods A total of 102 patients with advanced threatened abortion from October 2015 to October 2018 were selected as research subjects, and were divided into the study group and the control group by the random number table method, with 51 cases in each group.The control group was treated with Magnesium Sulfate combined with Ritodrine Hydrochloride, while the study group was treated with Atosiban combined with Ritodrine Hydrochloride.The levels of sex hormones (progesterone [P], estriol [E3]) were compared between the two groups before treatment and after 5 d of treatment.The pregnancy outcomes (neonatal Apgar score at 1 min after birth, low weight infant rate, fetal loss rate) were compared between the two groups.Results After treatment, the P level in the study group was higher than that before treatment (P＜0.05), and the P level in the study group was higher than that in the control group (P＜0.05), and the E3 level in the study group after treatment was lower than that before treatment (P＜0.05), and the E3 level in the study group was lower than that in the control group (P＜0.05).The incidence rate of low birth weight infants in the study group was lower than that in the control group (P＜0.05), and there were no significant differences in the neonatal Apgar score at 1 min after birth and fetal loss rate between the two groups (P＞0.05).Conclusion Atosiban for advanced threatened abortion can improve the sex hormones levels and pregnancy outcomes of patients.

Key words： Atosiban Magnesium sulfate Ritodrine hydrochloride Advanced threatened abortion Sex hormones levels Pregnancy outcomes

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WU Dan-dan. Clinical effect of Atosiban combined with Ritodrine Hydrochloride in the treatment of advanced threatened abortion[J]. 中国当代医药, 2020, 27(22): 138-140.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I22/138

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